[Erratum to: Methamphetamine. Epidemiology, clinical importance and sequelae of abuse].
PMID: 28852766 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - August 29, 2017 Category: Neurology Authors: Arnaud N, Thomasius R Tags: Nervenarzt Source Type: research

[Myoclonus as a  movement disorder].
This article gives a short survey and characterizes in detail two common types of myoclonus, cortical myoclonus and reticular reflex myoclonus. Clinical testing and electrophysiological investigations provide relevant local diagnostic indications for the generating structure(s). Such indications would influence not only the strategies of neuroimaging and laboratory investigations aimed at clarifying the underlying cause but also the selection of drugs to suppress myoclonus. PMID: 28852800 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - August 29, 2017 Category: Neurology Authors: Meinck HM Tags: Nervenarzt Source Type: research

[Syncope, transient ischemic attacks, transient global amnesia and migraine].
Abstract Epileptic seizures can manifest with a variety of clinical symptoms. Depending on the dominant symptom, several differential diagnoses have to be considered. Their differentiation can be challenging, especially after the first episode. The review article summarizes the most common differential diagnoses as well as their characteristics compared to epileptic seizures, aiming at providing guidelines for their clinical differentiation. Whenever a clear diagnosis is not possible based on the patient history and clinical signs, diagnostic evaluation with, e. g. an electroencephalogram (EEG) and fin...
Source: Der Nervenarzt - August 28, 2017 Category: Neurology Authors: Hartl E Tags: Nervenarzt Source Type: research

[Leucotomy in the early Federal Republic of Germany].
Abstract Leucotomy was introduced in 1936 in Europe as a therapy for mental illness. With the end of World War II leucotomy was also introduced in the early Federal Republic of Germany. Leucotomy was applied in cases of, for example schizophrenia, depression, obsessive-compulsive disorders or even some psychopathic disorders. The operations were carried out in neurosurgical departments outside psychiatric hospitals or patients were also transferred to those which had been established in psychiatric and neurological clinics. Based on published conference reports, retrospective case reports, dissertations ...
Source: Der Nervenarzt - August 28, 2017 Category: Neurology Authors: Rzesnitzek L Tags: Nervenarzt Source Type: research

[Multiprofessional inpatient psychotherapy of depression in old age].
MJ Abstract Depression is common in old age but is often underdiagnosed and inadequately treated. Although psychotherapy is considered effective for treating elderly patients with depression, it is rarely applied in inpatient settings. Furthermore, treatment on inpatient units specialized for elderly patients and implementation of a psychotherapeutic treatment approach are currently more the exception. From this background, a multiprofessional inpatient behavioral treatment program (MVT) for elderly depressed patients was developed at a specialized unit of a university-affiliated regional psyc...
Source: Der Nervenarzt - August 28, 2017 Category: Neurology Authors: Cabanel N, Kundermann B, Franz M, Müller MJ Tags: Nervenarzt Source Type: research

[Body weight and mental disorders : Results from a  clinical psychiatric cross-sectional study of people with intellectual disabilities].
CONCLUSION: Young women with ID and mental disorders were particularly at risk for obesity. The respective factors may support the development of specific prevention programs to reduce the risk of overweight and thereby lead to better mental and physical health in people with ID. PMID: 28849297 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - August 28, 2017 Category: Neurology Authors: Franke ML, Heinrich M, Adam M, Sünkel U, Diefenbacher A, Sappok T Tags: Nervenarzt Source Type: research

[Diagnosis of non-epileptic paroxysmal disorders and epileptic seizures].
n B Abstract Non-epileptic paroxysmal disorders may clinically manifest in a similar way to epileptic seizures and have to be considered in the differential diagnosis of epilepsy. Syncope, non-epileptic psychogenic seizures, paroxysmal movement disorders, migraine, transient ischemic attacks and parasomnia constitute the major differential diagnoses. A meticulous history and a third party description are useful for the differential diagnosis. Neurological, psychiatric and cardiological examinations are required for the correct differential diagnosis. The interictal electroencephalogram (EEG), which is normal ...
Source: Der Nervenarzt - August 25, 2017 Category: Neurology Authors: Noachtar S, Güldiken B Tags: Nervenarzt Source Type: research

[On the road to psychiatric reform : Reconstructing the political preparation of the first Enquete Commission of the German Bundestag].
CONCLUSION: The Enquete was not a straightforward process and was also not tied to any moment. It fits more into the longer-term reform process of psychiatry in the Federal Republic of Germany. PMID: 28842729 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - August 25, 2017 Category: Neurology Authors: Söhner F, Fangerau H, Becker T Tags: Nervenarzt Source Type: research

[Long-term efficacy of multimodal pain therapy for chronic back pain].
CONCLUSION: Multimodal pain therapy is an effective method for the treatment of chronic back pain. It not only leads to short and medium-term improvements but also proves to be efficient in the long term. This form of pain therapy seems to lead to long-term success, particularly for patients with low-grade chronification. PMID: 28831509 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - August 22, 2017 Category: Neurology Authors: Zhuk A, Schiltenwolf M, Neubauer E Tags: Nervenarzt Source Type: research

[Advance directive of probands in pharmaceutical research : A medical ethics discussion].
This article describes the existing conditional need for group beneficial research and presents the problem of the decisive instrument for advance directives at the center of the considerations. The features of the proband advance directive concluded by the legislature stand in opposition to a successful implementation, particularly due to the necessary concrete clarification content far in advance for informed research participants. This article describes solution possiblities, which refer to the realization of the instrument of a proxy research authorization as well as the consideration of an advance research planning ba...
Source: Der Nervenarzt - August 22, 2017 Category: Neurology Authors: Haupt M, Jessen F, Fangerau H Tags: Nervenarzt Source Type: research

[Parasomnia and paroxysmal dyskinesia].
ml;tzel K Abstract Short involuntary paroxysmal movements or behavioral patterns are an important differential diagnosis to epileptic seizures, especially when occurring for the first time. Typically, these attacks are not witnessed by medically trained personnel and the patient anamnesis or observations by a third party are often not specific enough to differentiate between epileptic seizures and the differential diagnoses. This review presents the epidemiology, the clinical presentation, the necessary diagnostic steps and the differential diagnostic approach to parasomnias and dyskinesias. The focus is on the cl...
Source: Der Nervenarzt - August 22, 2017 Category: Neurology Authors: Rémi J, Bötzel K Tags: Nervenarzt Source Type: research

[Differential diagnosis of epileptic seizures : What is epilepsy and what is not?]
PMID: 28831515 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - August 22, 2017 Category: Neurology Authors: Noachtar S Tags: Nervenarzt Source Type: research

[Psychotherapy for posttraumatic stress disorder in older adults].
CONCLUSION: Future research should take account of the results so far in order to verify the existing preliminary results and to deal with current limitations. Randomized controlled trials are required, which should include a heterogeneous sample of elderly people and examine different therapeutic approaches in their effectiveness and feasibility in this cohort. PMID: 28831533 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - August 22, 2017 Category: Neurology Authors: Böttche M, Knaevelsrud C Tags: Nervenarzt Source Type: research

[Importance of imaging diagnostics and EEG for differential diagnosis of epileptic seizures].
Abstract Electroencephalography (EEG) and neuroimaging are the two most crucial diagnostic methods for epilepsy. The EEG represents the only specific method to detect epileptogenicity of a brain lesion. The EEG shows some syndrome-specific alterations, helps to make therapeutic decisions and allows prognosis about the disease. Neuroimaging in epilepsy includes magnetic resonance imaging (MRI), computed tomography (CT), positron emission tomography (PET) and single-photon emission computed tomography (SPECT). Neuroimaging is crucial to clarify the underlying etiology and to localize the epileptogenic zone and ...
Source: Der Nervenarzt - August 22, 2017 Category: Neurology Authors: Vollmar C, Noachtar S Tags: Nervenarzt Source Type: research

[Therapy drop-out as a  predictor of re-delinquency : Legal probation of substance addicted patients according to §64 of the German Legal Code].
DISCUSSION: Patients serving prison sentences after unsuccessful forensic treatment are a high-risk group for recidivism. Alternative concepts of clinical and legal treatment of this group should be developed. PMID: 28785776 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - August 7, 2017 Category: Neurology Authors: Querengässer J, Bulla J, Hoffmann K, Ross T Tags: Nervenarzt Source Type: research

[Can online therapy meaningfully complement psychotherapy? Pro].
PMID: 28776211 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - August 3, 2017 Category: Neurology Authors: Hautzinger M, Fuhr K Tags: Nervenarzt Source Type: research

[Use of social media by psychiatric in-patients : Case report and further perspectives].
We report about a 25-year-old patient with a diagnosis of borderline personality disorder who posted photographs of acute self-injuries to a group of fellow patients by means of a messenger app while on weekend leave during psychiatric hospital treatment. The implications about possible effects of the use of social media by psychiatric in-patients on treatment and group dynamics are discussed. Furthermore, social media communication by patients is focused on in general and potential consequences for psychiatric, psychotherapeutic and psychosomatic treatment are discussed. PMID: 28776212 [PubMed - a...
Source: Der Nervenarzt - August 3, 2017 Category: Neurology Authors: Czech OM, Podoll K, Schneider F Tags: Nervenarzt Source Type: research

[Standards for treatment in forensic committment according to § 63 and § 64 of the German criminal code : Interdisciplinary task force of the DGPPN].
[Standards for treatment in forensic committment according to § 63 and § 64 of the German criminal code : Interdisciplinary task force of the DGPPN]. Nervenarzt. 2017 Aug 03;: Authors: Müller JL, Saimeh N, Briken P, Eucker S, Hoffmann K, Koller M, Wolf T, Dudeck M, Hartl C, Jakovljevic AK, Klein V, Knecht G, Müller-Isberner R, Muysers J, Schiltz K, Seifert D, Simon A, Steinböck H, Stuckmann W, Weissbeck W, Wiesemann C, Zeidler R Abstract People who have been convicted of a crime due to a severe mental disorder and continue to be dangerous as a result o...
Source: Der Nervenarzt - August 3, 2017 Category: Neurology Authors: Müller JL, Saimeh N, Briken P, Eucker S, Hoffmann K, Koller M, Wolf T, Dudeck M, Hartl C, Jakovljevic AK, Klein V, Knecht G, Müller-Isberner R, Muysers J, Schiltz K, Seifert D, Simon A, Steinböck H, Stuckmann W, Weissbeck W, Wiesemann C, Zeidler R Tags: Nervenarzt Source Type: research

[Real-world evidence : Benefits and limitations in multiple sclerosis research].
CONCLUSION: There is still a need for high-quality, comprehensive, and valid RWE data as these data cover additional aspects of patient care and expand the data available by complementary information. Further development of an integrative RWE approach requires cooperation at various levels with the aim of the best possible standardization and harmonization of clinical MS data. PMID: 28776214 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - August 3, 2017 Category: Neurology Authors: Ziemssen T, Rothenbacher D, Kuhle J, Berger T Tags: Nervenarzt Source Type: research

[Cavernomas of the central nervous system : Observational study of 111 patients].
CONCLUSION: As a result of our findings we think it is important to critically look at the indications for surgical removal of cavernomas and special attention must be paid to informed consent of the patient. The frequent appearance of temporal cavernomas and their propensity to epileptic seizures is an essential aspect, which certainly influences the therapeutic decision. Although cavernomas are a venous malformation in the low blood pressure system, the determined frequency of hemorrhage was 5.9%, which was higher than expected but which is confirmed by other studies. Reports on severe sequelae of cavernoma bleeding...
Source: Der Nervenarzt - August 3, 2017 Category: Neurology Authors: Mayer C, Mauer UM, Bluhm G, Mathieu R, Hackenbroch C, Mayer S Tags: Nervenarzt Source Type: research

[Validation of interaction databases in psychopharmacotherapy].
DISCUSSION: The best results in this comparison were achieved by MediQ but this database also needs improvement with respect to the hit rate so that the users can rely on the results and therefore increase drug therapy safety. PMID: 28741067 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - July 24, 2017 Category: Neurology Authors: Hahn M, Roll SC Tags: Nervenarzt Source Type: research

[Can online therapy meaningfully complement psychotherapy? Con].
PMID: 28730392 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - July 20, 2017 Category: Neurology Authors: Noack R, Weidner K Tags: Nervenarzt Source Type: research

[Fulminant EBV meningoencephalitis : Good clinical outcome in a  young, immunocompetent female].
[Fulminant EBV meningoencephalitis : Good clinical outcome in a young, immunocompetent female]. Nervenarzt. 2017 Jul 20;: Authors: Derler F, Seidel S, Bengel D PMID: 28730393 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - July 20, 2017 Category: Neurology Authors: Derler F, Seidel S, Bengel D Tags: Nervenarzt Source Type: research

[Methamphetamine : Epidemiology, clinical importance and sequelae of abuse].
Abstract Methamphetamine (also known as meth and crystal meth) is a highly psychoactive synthetic amphetamine type stimulant, which falls under the German Federal Narcotics Law. The substance is similar to other stimulants but has distinct features with respect to psychoactive effects, clinical symptoms, user characteristics and short and long-term consequences including substance-induced problems and comorbidities. The consumption and misuse of crystal meth is still limited to certain regions in Germany; however, the substance causes significant clinical and public health concerns in the affected regions and...
Source: Der Nervenarzt - July 18, 2017 Category: Neurology Authors: Arnaud N, Thomasius T Tags: Nervenarzt Source Type: research

[Computational neuroanatomy and microstructure imaging using magnetic resonance imaging].
CONCLUSION: Non-invasive brain tissue characterization using qMRI or hMRI has significant implications for both scientific and clinical applications. Both approaches improve the comparability across sites and time points, facilitate multicenter and longitudinal studies as well as standardized diagnostics. The hMRI is expected to shed new light on the relationship between brain microstructure, function and behavior both in health and disease. In the future hMRI will play an indispensable role in the field of computational neuroanatomy. PMID: 28721539 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - July 18, 2017 Category: Neurology Authors: Mohammadi S, Weiskopf N Tags: Nervenarzt Source Type: research

[Myasthenia gravis should be considered in cases of Parkinson's disease and progressive dysphagia].
We report on four consecutive patients with Parkinson's disease, in whom anti-acetylcholine receptor (AChR) antibody positive bulbar myasthenia gravis (MG) turned out to be responsible for progressive dysphagia. PMID: 28698898 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - July 11, 2017 Category: Neurology Authors: Urban PP, Stammel O Tags: Nervenarzt Source Type: research

[Diagnostic and treatment standards for cerebral sinus venous thrombosis : Results of an online survey of German stroke units].
CONCLUSION: The survey revealed substantial homogeneity between RSUs and SRSUs and standards are mostly in line with the guidelines. Non-established procedures, such as invasive therapeutic procedures and the administration of new oral anticoagulants were used significantly more often in SRSUs. PMID: 28695244 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - July 10, 2017 Category: Neurology Authors: Geisbüsch C, Ringleb PA, Busse O, Hamann GF, Nagel S Tags: Nervenarzt Source Type: research

[Genuine motor phenomena in schizophrenic psychoses : Theoretical background and definition of context].
Abstract Besides positive and negative symptoms, motor abnormalities have been increasingly recognized as central symptoms of schizophrenia. Recent investigations of antipsychotic-naive first-episode patients with schizophrenia found significantly higher rates of genuine motor abnormalities (GMA) when compared to healthy individuals. The first part of this article introduces the historical and clinical background of GMA in schizophrenia. In the second part the relevance of scientific research and clinical implication of GMA in schizophrenia are discussed. Finally, this article aims at presenting a conceptual ...
Source: Der Nervenarzt - July 7, 2017 Category: Neurology Authors: Hirjak D, Northoff G, Thomann PA, Kubera KM, Wolf RC Tags: Nervenarzt Source Type: research

[Network disorders in neurology].
k GR PMID: 28676944 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - July 4, 2017 Category: Neurology Authors: Claßen J, Saur D, Fink GR Tags: Nervenarzt Source Type: research

[Alzheimer dementia: course and burden on caregivers : Data over 18 months from German participants of the GERAS study].
Abstract The GERAS study is an international observational study with dementia patients of the Alzheimer type (AD) and their caregivers in everyday care. The 18-month data recorded in Germany are presented. Disease progression, medical and psychosocial consequences for both patients and caregivers were recorded using commonly used tests in clinical care: the mini mental status examination (MMSE), Alzheimer's disease assessment scale (ADAS-Cog14), Alzheimer's disease cooperative study activities of daily living inventory (ADCS-ADL), neuropsychiatric inventory (NPI-12), resource utilization in dementia (RUD) and the...
Source: Der Nervenarzt - July 3, 2017 Category: Neurology Authors: Hager K, Henneges C, Schneider E, Lieb M, Kraemer S Tags: Nervenarzt Source Type: research

[Networks involved in motor cognition : Physiology and pathophysiology of apraxia].
PH Abstract Apraxia is an umbrella term for different disorders of higher motor abilities that are not explained by elementary sensorimotor deficits (e. g. paresis or ataxia). Characteristic features of apraxia that are easy to recognize in clinical practice are difficulties in pantomimed or actual use of tools as well as in imitation of meaningless gestures. Apraxia is bilateral, explaining the cognitive motor disorders and occurs frequently (but not exclusively) after left hemispheric lesions, as well as in neurodegenerative diseases, such as corticobasal syndrome and Alzheimer's disease. Apraxic deficit...
Source: Der Nervenarzt - June 29, 2017 Category: Neurology Authors: Martin M, Hermsdörfer J, Bohlhalter S, Weiss PH Tags: Nervenarzt Source Type: research

[Multimodal treatment of patients with bipolar disorder necessitates sufficient personnel resources].
PMID: 28656343 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - June 27, 2017 Category: Neurology Authors: Pfennig A Tags: Nervenarzt Source Type: research

[The importance of neuronal networks for motor rehabilitation after a stroke].
Abstract Every year in Europe 1.5 million patients suffer a new stroke. Despite the further developments in acute therapy with nationwide stroke units, thrombolysis, thrombectomy and post-acute neurorehabilitation, only a small proportion of patients recover to a satisfactory degree allowing them to return to their normal social and professional life. This makes stroke the main cause of long-term disability with a corresponding impact on patient lives, socioeconomics and the healthcare system. Thus, the concepts of neurorehabilitation have to be extended to enhance the effects of rehabilitative treatment stra...
Source: Der Nervenarzt - June 27, 2017 Category: Neurology Authors: Hummel FC Tags: Nervenarzt Source Type: research

[Psychiatric care of refugees in Africa and the Middle East : Challenges and solutions].
We present first initiatives to improve psychiatric care in refugee camps in Ethiopia, Kenya, and Sudan. Moreover, we provide first insights into a project based in Northern Iraq and Germany aimed at the treatment of people who were severely traumatized by the terror regime of the so-called Islamic State (IS). PMID: 28646248 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - June 23, 2017 Category: Neurology Authors: Adorjan K, Mulugeta S, Odenwald M, Ndetei DM, Osman AH, Hautzinger M, Wolf S, Othman M, Kizilhan JI, Pogarell O, Schulze TG Tags: Nervenarzt Source Type: research

[Unsuitable guideline recommendations for psychotherapeutic treatment of manias].
PMID: 28642980 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - June 22, 2017 Category: Neurology Authors: Zinkler M Tags: Nervenarzt Source Type: research

[Mental health as a  global challenge : Research, care and participation].
[Mental health as a global challenge : Research, care and participation]. Nervenarzt. 2017 Jun 22;: Authors: Deister A, Falkai P, Heinz A PMID: 28642981 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - June 22, 2017 Category: Neurology Authors: Deister A, Falkai P, Heinz A Tags: Nervenarzt Source Type: research

[Healthcare models for traumatized refugees in Germany].
Abstract People with a migration background are a risk group for psychiatric disorders. Innovative, transnational and sustainable projects are necessary to ensure adequate care for refugees and asylum seekers. Selected projects of the University of Munich, the Charité Berlin and the University of Konstanz show promising approaches in addition to other initiatives. PMID: 28642982 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - June 22, 2017 Category: Neurology Authors: Adorjan K, Kluge U, Heinz A, Stamm T, Odenwald M, Dohrmann K, Mokhtari-Nejad R, Hasan A, Schulze TG, Falkai P, Pogarell O Tags: Nervenarzt Source Type: research

[Hebephrenia - a  viable psychopathological construct?]
[Hebephrenia - a viable psychopathological construct?] Nervenarzt. 2017 Jun 22;: Authors: Jäger M, Becker T, Wigand ME Abstract Ewald Hecker was the first psychiatrist to describe the disease entity of hebephrenia in some detail, focusing mainly on disturbances of affect. Later Emil Kraepelin and Eugen Bleuler saw hebephrenia as a subtype of dementia praecox or schizophrenia. Willy Mayer-Gross and Karl Leonhard characterized hebephrenia with highly differentiated psychopathological descriptions, whereas this construct only played a minor role in the works of Klaus Conrad and Kurt S...
Source: Der Nervenarzt - June 22, 2017 Category: Neurology Authors: Jäger M, Becker T, Wigand ME Tags: Nervenarzt Source Type: research

[Psychotraumatology : Differentiation, extension and public discourse].
Abstract The first description of posttraumatic stress disorder (PTSD) in the 1980s marked the origin of psychotraumatology. Based on the variety of developments in the meantime and being relevant for basic research and clinical application, a differentiation of diagnoses according to the new International Classification of Diseases (ICD-11) are presented including PTSD, complex PTSD, prolonged grief disorder and adjustment disorder. In addition, extension towards traumatic and adverse childhood experiences and their significance for lifetime mental and somatic morbidity are described. Concerning these childhood t...
Source: Der Nervenarzt - June 21, 2017 Category: Neurology Authors: Maercker A, Augsburger M Tags: Nervenarzt Source Type: research

[Psychiatric emergencies].
Abstract Psychiatric emergencies present a frequent and interdisciplinary challenge. Clinical diagnosis and management are complicated by the acuity, and the patient's compliance is often limited by the illness. Psychiatric emergencies include states of acute agitation, suicidality, delirium, stupor, and drug-induced emergencies. Sometimes interventions such as conversational contact, responding empathically to patients, or "talking down" are sufficient. If pharmacotherapy is necessary, benzodiazepines and antipsychotic drugs are the primary agents of choice. PMID: 28623497 [PubMed - as supplie...
Source: Der Nervenarzt - June 16, 2017 Category: Neurology Authors: Schneider F, Weber-Papen S Tags: Nervenarzt Source Type: research

[Epileptic seizures and epilepsy after a stroke : Incidence, prevention and treatment].
Abstract Following stroke, 3-6% of patients develop acute symptomatic seizures within the first 7 days. The rate is higher after cerebral haemorrhage compared to ischaemia. In 10-12% of patients, after more than 7 days unprovoked seizures occur. Due to these low incidence rates, primary prophylaxis with antiepileptic drugs is generally not necessary. Following one acute symptomatic seizure, recurrence risk within the first 7 days post-stroke is 10-20%, generally arguing against secondary prophylaxis with an antiepileptic drug. In clinical practice however, antiepileptic drug treatment in this conste...
Source: Der Nervenarzt - June 14, 2017 Category: Neurology Authors: Benninger F, Holtkamp M Tags: Nervenarzt Source Type: research

[Ataxias and hereditary spastic paraplegias].
ml;ls L Abstract Hereditary ataxias and spastic paraplegias are genetic disorders with age-dependent nearly complete penetrance. The mostly monogenetic etiology allows one to establish the diagnosis, study pathogenesis and to develop new causative therapeutic approaches for these diseases. Both the causative genes as well as the clinical presentation overlap considerably between hereditary ataxias and spastic paraplegias. This strongly argues towards a united classification for these two groups of diseases. Next generation sequencing technologies have greatly expanded the number of genes known to be causative...
Source: Der Nervenarzt - June 9, 2017 Category: Neurology Authors: Schüle R, Schöls L Tags: Nervenarzt Source Type: research

[Aphasia: a  neuronal network disorder].
[Aphasia: a neuronal network disorder]. Nervenarzt. 2017 Jun 08;: Authors: Stockert A, Saur D Abstract Language processing requires the coordinated interaction of local and distant neural populations within distributed networks of the temporal, frontal and parietal brain regions. Poststroke aphasia is the consequence of both local as well as remote dysfunction within language-specific and domain-general networks. Language recovery, in turn, rests on reorganization processes within these networks. These comprise the resolution of an acute network failure (i. e. diaschisis), the subacute act...
Source: Der Nervenarzt - June 8, 2017 Category: Neurology Authors: Stockert A, Saur D Tags: Nervenarzt Source Type: research

[Shared decision-making in acute psychiatric medicine : Contraindication or a challenge?]
DISCUSSION: On top of the ubiquitous shortage of time in clinical routine, psychiatrists report their concern about patients' limited abilities in sharing decisions and their own fear of potentially harmful decisions resulting from a shared process. Misinterpretation of shared decision-making restricting the health care professional to rather an informed choice scenario and their own adhesion to the traditional paternalistic decision-making approach further add to SDM's underutilization. Those hurdles could be overcome by communication skill workshops for all mental health care professionals, including nursing personn...
Source: Der Nervenarzt - June 8, 2017 Category: Neurology Authors: Heres S, Hamann J Tags: Nervenarzt Source Type: research

[Genetic risk factors for neuropsychiatric disorders].
PMID: 28597030 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - June 8, 2017 Category: Neurology Authors: Gasser T, Maier W Tags: Nervenarzt Source Type: research

[Search for risk genes in Alzheimer's disease].
Abstract Alzheimer's disease (AD) is the most common form of neurodegenerative dementia. The susceptibility to AD is determined by a complex interaction between genetic, epigenetic, and environmental factors. Herein, the risk that can be attributed to genetic factors is high (up to 80%). While most AD patients are sporadic, in rare families Mendelian mode of inheritance can be observed. In these rare familial cases, full penetrant mutations have been identified in APP, PSEN1, and PSEN2. Mutations in these three genes are however rarely found in sporadic AD. For over 20 years, the only known genetic risk ...
Source: Der Nervenarzt - June 2, 2017 Category: Neurology Authors: Karaca I, Wagner H, Ramirez A Tags: Nervenarzt Source Type: research

[Risk genes in myopathies and mitochondrial diseases].
Abstract Myopathies and mitochondrial diseases pose a major challenge in diagnosis due to the multitude of different entities and - in the case of mitochondriopathies - the possible involvement of multiple organs. Furthermore, there is broad clinical variability within particular diseases; patients with hereditary myopathy, for example, can show great phenotypic variability despite identical genetic defects. In addition to environmental factors, gender-specific influences, and the degree of heteroplasmy in mitochondrial diseases, the existence of disease-modifying genes has long been assumed as an explanation...
Source: Der Nervenarzt - June 1, 2017 Category: Neurology Authors: Stendel C, Walter MC, Klopstock T Tags: Nervenarzt Source Type: research

[Genetic architecture of amyotrophic lateral sclerosis and frontotemporal dementia : Overlap and differences].
Abstract Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) overlap not only clinically, but also with respect to shared neuropathology and genes. A large number of novel genes has recently been identified which underlie both diseases, e. g., C9orf72, TARDBP, GRN, TBK1, UBQLN2, VCP, CHCHD10, or SQSTM1. In contrast, other genes are still largely associated with only one of the two diseases, e. g., SOD1 with ALS or MAPT with FTD. These genetic findings indicate a large number of shared mechanisms, yet along with still a certain cell-specific vulnerability. The recently...
Source: Der Nervenarzt - June 1, 2017 Category: Neurology Authors: Synofzik M, Otto M, Ludolph A, Weishaupt JH Tags: Nervenarzt Source Type: research

[Home treatment for people with acute mental illnesses].
Abstract Home treatment has been proposed as an alternative to acute psychiatric inpatient treatment. Health insurance systems in Germany and in Switzerland hinder the nationwide implementation of home treatment teams into mental health systems, although the German S3 guidelines for psychosocial treatments of severe mental illnesses recommend provision of acute care at home. Evidence for home treatment is positive, yet there are only few up-to-date studies from Europe and differential indication criteria are lacking. The aim of home treatment is to reduce inpatient bed-days by nonadmission or early discharge. Home...
Source: Der Nervenarzt - June 1, 2017 Category: Neurology Authors: Hepp U, Stulz N Tags: Nervenarzt Source Type: research

[Genetic findings in autism spectrum disorders].
This article gives an overview on current basic genetic research in ASD, its clinical relevance and genetic counselling in ASD. PMID: 28536874 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - May 23, 2017 Category: Neurology Authors: Freitag CM Tags: Nervenarzt Source Type: research