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Condition: Hypothermia

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Total 450 results found since Jan 2013.

Blood biomarker changes following therapeutic hypothermia in ischemic stroke
ConclusionAlthough the exact roles of MMP3, FABP, and IL-8 in hypothermia-treated stroke patients are not known, further exploration is needed to confirm their roles in brain ischemia.
Source: Brain and Behavior - September 18, 2023 Category: Neurology Authors: Elena Pal à, Anna Penalba, Alejandro Bustamante, Teresa García‐Berrocoso, Marcel Lamana‐Vallverdú, Christian Meisel, Andreas Meisel, H. Bart van der Worp, Malcolm R Macleod, Bernd Kallmünzer, Stefan Schwab, Joan Montaner Tags: BRIEF REPORT Source Type: research

Enhanced Neuroprotection by Local Intra-Arterial Infusion of Human Albumin Solution and Local Hypothermia Brief Reports
Conclusions— The local low-dose cold albumin infusion into the ischemic area offered a combination of regional brain hypothermia and albumin administration, which enhanced neuroprotection and would be beneficial in the clinical setting.
Source: Stroke - December 24, 2012 Category: Neurology Authors: Chen, J., Fredrickson, V., Ding, Y., Cheng, H., Wang, N., Ling, F., Ji, X. Tags: Acute Cerebral Infarction, Neuroprotectors Brief Reports Source Type: research

Function of the master energy regulator adenosine monophosphate‐activated protein kinase in stroke
Abstract Adenosine monophosphate‐activated protein kinase (AMPK) is an evolutionarily conserved signaling molecule that is emerging as one of the most important energy sensors in the body. AMPK monitors cellular energy status and is activated via phosphorylation when energy stores are low. This allows for maintenance of energy homeostasis by promoting catabolic pathways for ATP production and limiting processes that consume ATP. Growing number of stimuli have been shown to activate AMPK, and AMPK has been implicated in many diverse biological processes, including cell polarity, autophagy, and senescence. The effect of AM...
Source: Journal of Neuroscience Research - March 6, 2013 Category: Neuroscience Authors: Bharti Manwani, Louise D. McCullough Tags: Review Source Type: research

Endogenous ghrelin's role in hippocampal neuroprotection after global cerebral ischemia: does endogenous ghrelin protect against global stroke?
Abstract Ghrelin is a gastrointestinal hormone with a well-characterized role in feeding and metabolism. Evidence suggests ghrelin may also be neuroprotective after injury in animal models of cerebral ischemia. Thus, exogenous ghrelin treatment can improve cell survival, reduce infarct size, and rescue memory deficits in focal ischemia models, doing so by suppressing inflammation and apoptosis. Endogenous ghrelin plays a key a role in a number of physiological processes, including feeding, metabolism, stress, and anxiety. However, no study has examined whether endogenous ghrelin also contributes to neuroprotection...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - April 10, 2013 Category: Physiology Authors: Kenny R, Cai G, Bayliss JA, Clarke M, Choo YL, Miller AA, Andrews ZB, Spencer SJ Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research

Increased cytokine and chemokine gene expression in the CNS of mice during heat stroke recovery
Heat stroke (HS) is characterized by a systemic inflammatory response syndrome (SIRS) consisting of profound core temperature (Tc) changes in mice. Encephalopathy is common at HS collapse, but inflammatory changes occurring in the brain during the SIRS remain unidentified. We determined the association between inflammatory gene expression changes in the brain with Tc disturbances during HS recovery in mice. Gene expression changes of heat shock protein (HSP)72, heme oxygenase (hmox1), cytokines (IL-1β, IL-6, TNF-α), cyclooxygenase enzymes (COX-1, COX-2), chemokines (MCP-1, MIP-1α, MIP-1β, CX3CR1), and...
Source: AJP: Regulatory, Integrative and Comparative Physiology - November 1, 2013 Category: Physiology Authors: Biedenkapp, J. C., Leon, L. R. Tags: Call for Papers Source Type: research

Pharmacologically induced hypothermia via TRPV1 channel agonism provides neuroprotection following ischemic stroke when initiated 90 min after reperfusion
We examined effectiveness and specificity of pharmacological hypothermia (PH) by transient receptor potential vanilloid 1 (TRPV1) channel agonism in the treatment of focal cerebral I/R. Core temperature (Tcore) was measured after subcutaneous infusion of TRPV1 agonist dihydrocapsaicin (DHC) in conscious C57BL/6 WT and TRPV1 knockout (KO) mice. Acute measurements of heart rate (HR), mean arterial pressure (MAP), and cerebral perfusion were measured before and after DHC treatment. Focal cerebral I/R (1 h ischemia + 24 h reperfusion) was induced by distal middle cerebral artery occlusion. Hypothermia (>8 h) was initiated 9...
Source: AJP: Regulatory, Integrative and Comparative Physiology - January 15, 2014 Category: Physiology Authors: Cao, Z., Balasubramanian, A., Marrelli, S. P. Tags: Neural Control Source Type: research

Targeted temperature management after intracerebral hemorrhage (TTM‐ICH): methodology of a prospective randomized clinical trial
ConclusionMore research of novel therapies to improve outcomes after intracerebral hemorrhage is desperately needed. The results of the targeted temperature management after intracerebral hemorrhage clinical trial may provide additional information on the applicability of targeted temperature management after intracerebral hemorrhage.
Source: International Journal of Stroke - January 23, 2014 Category: Neurology Authors: Fred Rincon, David P. Friedman, Rodney Bell, Stephan A. Mayer, Paul F. Bray Tags: Protocols Source Type: research

Cardiovascular and thermoregulatory biomarkers of heat stroke severity in a conscious rat model
This study identified novel biomarkers that predict HS severity and organ damage during acute recovery that could provide clinical significance for identifying key biomarkers of HS pathogenesis.
Source: Journal of Applied Physiology - November 1, 2014 Category: Physiology Authors: Quinn, C. M., Duran, R. M., Audet, G. N., Charkoudian, N., Leon, L. R. Tags: ARTICLES Source Type: research

National Institute for Health Research launches “Focus on Stroke” as ground-breaking stroke trial opens in the UK
EuroHYP-1, the largest worldwide clinical trial of a new revolutionary stroke treatment called Therapeutic Hypothermia, is due to open in the UK. The study is just one of those featured on “Focus on Stroke”, a new online resource from the National Institute for Health Research (NIHR) aimed at raising public awareness of the exciting developments...
Source: NIHR Evaluation, Trials and Studies News - February 24, 2014 Category: American Health Source Type: news

Revisiting cerebral postischemic reperfusion injury: new insights in understanding reperfusion failure, hemorrhage, and edema
Cerebral postischemic reperfusion injury is defined as deterioration of ischemic brain tissue that parallels and antagonizes the benefits of restoring cerebral circulation after therapeutic thrombolysis for acute ischemic stroke. To understand the paradox of injury caused by treatment, we first emphasize the phenomenon in which recanalization of an occluded artery does not lead to tissue reperfusion. Additionally, no‐reflow after recanalization may be due to injury of the neurovascular unit, distal microthrombosis, or both, and certainly worsens outcome. We examine the mechanism of molecular and subcellular damage in the...
Source: International Journal of Stroke - January 19, 2015 Category: Neurology Authors: Jilin Bai, Patrick D. Lyden Tags: Review Source Type: research

Combined Selective Cerebral Hypothermia and Mechanical Artery Recanalization in Acute Ischemic Stroke: In Vitro Study of Cooling Performance INTERVENTIONAL
CONCLUSIONS: The feasibility of intracarotid blood cooling using a new catheter system was demonstrated in vitro. A serial 4-balloon array led to an optimized cooling capacity approaching optimum target temperatures of mild therapeutic hypothermia. To determine the therapeutic efficacy of combined selective therapeutic hypothermia and mechanical thrombectomy, further in vivo studies by using a model of temporary ischemia with large-vessel occlusion and recanalization are required.
Source: American Journal of Neuroradiology - November 13, 2015 Category: Radiology Authors: Cattaneo, G., Schumacher, M., Wolfertz, J., Jost, T., Meckel, S. Tags: INTERVENTIONAL Source Type: research

Intracranial pressure elevation after ischemic stroke in rats: cerebral edema is not the only cause, and short-duration mild hypothermia is a highly effective preventive therapy
ae & Neil J Spratt
Source: Journal of Cerebral Blood Flow and Metabolism - December 1, 2015 Category: Neuroscience Authors: Lucy A MurthaDamian D McLeodDebbie PepperallSarah K McCannDaniel J BeardAmelia J TomkinsWilliam M HolmesChristopher McCabeI Mhairi MacraeNeil J Spratt Source Type: research

Improved Neurological Outcome With Mild Hypothermia in Surviving Patients With Massive Cerebral Hemispheric Infarction Clinical Sciences
Conclusions— Mild hypothermia seems to not reduce mortality in patients with massive cerebral hemispheric infarction but may improve the neurological outcome in survivors. An adequately powered multicenter randomized controlled trial seems warranted. Clinical Trial Registration— URL: http://www.chictr.org.cn. Unique identifier: ChiCTR-TCS-12002680.
Source: Stroke - January 25, 2016 Category: Neurology Authors: Su, Y., Fan, L., Zhang, Y., Zhang, Y., Ye, H., Gao, D., Chen, W., Liu, G. Tags: Treatment, Quality and Outcomes, Ischemic Stroke Clinical Sciences Source Type: research

Protective Effects and Magnetic Resonance Imaging Temperature Mapping of Systemic and Focal Hypothermia in Cerebral Ischemia Basic Science
Conclusions— Focal brain hypothermia requires longer cooling periods to achieve the same protective efficacy as SH. However, FH mainly affects the ischemic region, and therefore represents a promising and nonstressful alternative to SH.
Source: Stroke - August 21, 2016 Category: Neurology Authors: Vieites-Prado, A., Iglesias-Rey, R., Fernandez-Susavila, H., da Silva-Candal, A., Rodriguez-Castro, E., Grohn, O. H. J., Wellmann, S., Sobrino, T., Castillo, J., Campos, F. Tags: Animal Models of Human Disease, Basic Science Research, Magnetic Resonance Imaging (MRI), Cerebrovascular Disease/Stroke, Neuroprotectants Source Type: research

Sedation vs Intubation for Patients With Acute Stroke Undergoing Thrombectomy
To the Editor The Sedation vs Intubation for Endovascular Stroke Treatment (SIESTA) trial found no difference in the primary outcome (change in the NIHSS score after 24 hours) in patients receiving general anesthesia vs conscious sedation. However, there were differences in secondary outcomes, with patients receiving general anesthesia having a 10-minute delay in the door-to-needle interval and increased postinterventional complications, including hypothermia, delayed extubation, and pneumonia.
Source: JAMA - March 21, 2017 Category: Journals (General) Source Type: research