Role of Autophagy in Endothelial Damage and Blood-Brain Barrier Disruption in Ischemic Stroke [Basic Science Advances for Clinicians]
(Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: Kyeong-A Kim, Donggeun Shin, Jeong-Hyeon Kim, Young-Jun Shin, G.K. Rajanikant, Arshad Majid, Seung-Hoon Baek, Ok-Nam Bae Tags: Endothelium/Vascular Type/Nitric Oxide, Blood-Brain Barrier, Cerebrovascular Disease/Stroke, Ischemic Stroke Basic Science Advances for Clinicians Source Type: research

Stem Cell-Based Immunomodulation After Stroke [Topical Review]
(Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: Marieke C.S. Boshuizen, Gary K. Steinberg Tags: Inflammation, Stem Cells, Ischemic Stroke Topical Reviews Source Type: research

Imaging Endophenotypes of Stroke as a Target for Genetic Studies [Topical Review]
(Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: Xueqiu Jian, Myriam Fornage Tags: Genetic, Association Studies, Genetics, Cerebrovascular Disease/Stroke, Ischemic Stroke Topical Reviews Source Type: research

Patient-Reported Outcome Measures (PROMs) for Acute Stroke: Rationale, Methods and Future Directions [Topical Review]
(Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: Mathew Reeves, Lynda Lisabeth, Linda Williams, Irene Katzan, Moira Kapral, Anne Deutsch, Janet Prvu-Bettger Tags: Quality and Outcomes, Cerebrovascular Disease/Stroke Topical Reviews Source Type: research

Patent Foramen Ovale Closure Versus Medical Therapy for Cryptogenic Ischemic Stroke [Topical Review]
(Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: Jeffrey L. Saver, Heinrich P. Mattle, David Thaler Tags: Congenital Heart Disease, Treatment, Ischemic Stroke Topical Reviews Source Type: research

In the Era of Thrombectomy, Let Us Also Protect the Majority of Patients With Stroke Who Only Require Medical Treatment! [Comments and Opinions]
(Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: Enrique C. Leira, Sean I. Savitz Tags: Ethics and Policy, Health Services, Ischemic Stroke Comments and Opinions Source Type: research

Different Effects of Normobaric Oxygen in Normotensive Versus Hypertensive Rats After Focal Cerebral Ischemia [Brief Report]
Conclusions—NBO reduced infarction in Sprague–Dawley but not in spontaneously hypertensive rats. These findings suggest that comorbidities may influence responses to potential treatments after stroke. (Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: Jing Lan, Elga Esposito, Cenk Ayata, Aneesh B. Singhal, Eng H. Lo, Xunming Ji Tags: Ischemic Stroke Brief Reports Source Type: research

Effect of Antihypertensive Medication on Cerebral Small Vessel Disease [Brief Report]
Conclusions—AHM has a protective effect on the progression of white matter hyperintensities, but no effect on brain atrophy. There are no trials on the effect of AHM on lacunes, microbleeds, enlarged perivascular spaces, or acute small subcortical infarcts. (Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: Tessa van Middelaar, Tanja E. Argillander, Floris H.B.M. Schreuder, Jaap Deinum, Edo Richard, Catharina J.M. Klijn Tags: Primary Prevention, Hypertension, Magnetic Resonance Imaging (MRI), Meta Analysis, Cerebrovascular Disease/Stroke Brief Reports Source Type: research

Time to Decision and Treatment With tPA (Tissue-Type Plasminogen Activator) Using Telemedicine Versus an Onboard Neurologist on a Mobile Stroke Unit [Brief Report]
Conclusions—Assessment by a TM-VN is comparable with an OB-VN in making decisions about tPA administration on an MSU and does not lead to treatment delays.Clinical Trial Registration—URL: https://www.clinicaltrials.gov. Unique identifier: NCT02190500. (Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: Ritvij Bowry, Stephanie A. Parker, Jose-Miguel Yamal, Hyunsoo Hwang, Savitri Appana, Nicole Rangel-Gutierrez, Tzu-Ching Wu, Suja S. Rajan, James C. Grotta Tags: Cerebrovascular Disease/Stroke, Ischemic Stroke Brief Reports Source Type: research

Low Levels of Caveolin-1 Predict Symptomatic Bleeding After Thrombolytic Therapy in Patients With Acute Ischemic Stroke [Brief Report]
Background and Purpose—Experimental models of cerebral ischemia demonstrate that the decrease in the caveolin-1 membrane protein results in an increase in endothelial permeability. Because this phenomenon is responsible for hemorrhagic transformation (HT) after cerebral ischemia, we aimed to determine whether caveolin-1 levels may predict bleeding after recombinant tissue-type plasminogen activator (r-tPA) administration in patients with acute stroke.Methods—We studied 133 patients with a first hemispheric stroke treated with r-tPA within 4.5 hours of symptom onset. HT was evaluated and classified on cranial co...
Source: Stroke - May 25, 2018 Category: Neurology Authors: Mar Castellanos, Cecile van Eendenburg, Carme Gubern, Elisabet Kadar, Gemma Huguet, Josep Puig, Tomas Sobrino, Gerard Blasco, Joaquin Serena, Juan Manuel Sanchez Tags: Biomarkers, Endothelium/Vascular Type/Nitric Oxide, Blood-Brain Barrier, Ischemic Stroke Brief Reports Source Type: research

Shorter Intensive Care Unit Stays? [Brief Report]
Conclusions—sICH associated with the administration of intravenous tPA typically occurs within the first 12 hours of treatment. Longer monitoring in an intensive care unit-like setting may be unnecessary for most individuals. (Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: Adam Chang, Edward J. Llinas, Karen Chen, Rafael H. Llinas, Elisabeth B. Marsh Tags: Cerebrovascular Disease/Stroke Brief Reports Source Type: research

Innovative Magnetic Resonance Imaging Markers of Hereditary Cerebral Amyloid Angiopathy at 7 Tesla [Brief Report]
Background and Purpose—The aim of the present study is to explore whether using 7 Tesla magnetic resonance imaging, additional brain changes can be observed in hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D) patients as compared with the established magnetic resonance imaging features of sporadic cerebral amyloid angiopathy.Methods—The local institutional review board approved this prospective cohort study. In all cases, informed consent was obtained. This prospective parallel cohort study was conducted between 2012 and 2014. We performed T2*-weighted magnetic resonance imaging performed at...
Source: Stroke - May 25, 2018 Category: Neurology Authors: Emma A. Koemans, Ellis S. van Etten, Anna M. van Opstal, Gerda Labadie, Gisela M. Terwindt, Marieke J.H. Wermer, Andrew G. Webb, Edip M. Gurol, Steven M. Greenberg, Mark A. van Buchem, Jeroen van der Grond, Sanneke van Rooden Tags: Magnetic Resonance Imaging (MRI), Cerebrovascular Disease/Stroke, Intracranial Hemorrhage, Vascular Disease Brief Reports Source Type: research

Distribution of Lacunar Infarcts in Asians With Intracerebral Hemorrhage [Brief Report]
Conclusions—Our findings expand on recent work showing that lobar lacunes are more frequent in CAA-ICH than hypertensive ICH. Their independent association with lobar cerebral microbleeds and brain amyloid deposition suggests a relationship with CAA even in an Asian cohort with overall higher hypertensive load. (Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: Hsin-Hsi Tsai, Marco Pasi, Li-Kai Tsai, Ya-Fang Chen, Bo-Ching Lee, Sung-Chun Tang, Panagiotis Fotiadis, Chen-Yu Huang, Ruoh-Fang Yen, M. Edip Gurol, Jiann-Shing Jeng Tags: Intracranial Hemorrhage Brief Reports Source Type: research

Combining Spot Sign and Intracerebral Hemorrhage Score to Estimate Functional Outcome [Brief Report]
Conclusions—In the PREDICT cohort, a prognostic score adding the computed tomographic angiography–based spot sign to the established ICH score did not improve functional outcome prediction compared with the ICH score. (Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: Hauke Schneider, Thien J. Huynh, Andrew M. Demchuk, Dar Dowlatshahi, David Rodriguez-Luna, Yolanda Silva, Richard Aviv, Imanuel Dzialowski Tags: Computerized Tomography (CT), Imaging, Prognosis, Cerebrovascular Disease/Stroke, Intracranial Hemorrhage Brief Reports Source Type: research

Relation of RhoA in Peripheral Blood Mononuclear Cells With Severity of Aneurysmal Subarachnoid Hemorrhage and Vasospasm [Brief Report]
Conclusions—Our preliminary results indicate that RhoA expression and activity in peripheral blood mononuclear cells might be related with aSAH severity and cerebral vasospasm. RhoA is a potential biomarker of the risks associated with aSAH. (Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: Maria del Carmen Gonzalez–Montelongo, Juan Jose Egea–Guerrero, Francisco Murillo–Cabezas, Rafaela Gonzalez–Montelongo, Zaida Ruiz de Azua–Lopez, Ana Rodriguez–Rodriguez, Angel Vilches–Arenas, Antonio Castellano, J Tags: Basic Science Research, Biomarkers Brief Reports Source Type: research

Misdiagnosis of Cerebral Vein Thrombosis in the Emergency Department [Brief Report]
Conclusions—In a large, heterogeneous multistate cohort, probable misdiagnosis of CVT occurred in 1 of 30 patients but was not associated with the adverse clinical outcomes included in our study. (Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: Ava L. Liberman, Gino Gialdini, Ekaterina Bakradze, Abhinaba Chatterjee, Hooman Kamel, Alexander E. Merkler Tags: Quality and Outcomes, Thrombosis Brief Reports Source Type: research

Synergistic Effects of Enriched Environment and Task-Specific Reach Training on Poststroke Recovery of Motor Function [Basic Sciences]
Conclusions—Task-specific reach training and environmental enrichment have synergistic effects in rats that persist long after rehabilitation ends, and this recovery is predicted by infarct volume and rehabilitation intensity. (Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: Matthew Strider Jeffers, Dale Corbett Tags: Animal Models of Human Disease, Rehabilitation, Ischemic Stroke Original Contributions Source Type: research

Role of Myeloid Lineage Cell Autophagy in Ischemic Brain Injury [Basic Sciences]
In this study, we investigated the roles of myeloid cell autophagy in ischemic brain injury.Methods—Focal cerebral ischemia was induced via transient middle cerebral artery occlusion in mice with autophagy-deficient myeloid lineage cells (Atg5flox/flox LysMCre+) and in their littermate controls (Atg5flox/flox). Infarct volume, neurological function, inflammatory cell infiltration, and proinflammatory cytokine expression levels were evaluated.Results—Mice lacking autophagy in myeloid lineage cells had a lower survival rate for 14 days than control mice (20% versus 70%; P (Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: Masakazu Kotoda, Hajime Furukawa, Takeshi Miyamoto, Masaaki Korai, Fumiaki Shikata, Atsushi Kuwabara, Xiaoxing Xiong, Caleb Rutledge, Rona G. Giffard, Tomoki Hashimoto Tags: Cerebral Aneurysm, Cerebrovascular Disease/Stroke, Ischemic Stroke Original Contributions Source Type: research

Early Blood-Brain Barrier Disruption in Ischemic Stroke Initiates Multifocally Around Capillaries/Venules [Basic Sciences]
Conclusions—Early BBBD in focal cerebral ischemia initiates multifocally in the distal capillary and venular bed of the cerebral microvasculature. It is closely associated with perimicrovascular vasogenic edema and microglial activation and predicts the extent of final infarction. (Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: Angelika Hoffmann, Tassilo Dege, Reiner Kunze, Anne–Sophie Ernst, Holger Lorenz, Laura–Ines Bohler, Thomas Korff, Hugo H. Marti, Sabine Heiland, Martin Bendszus, Xavier Helluy, Mirko Pham Tags: Biomarkers, Vascular Biology, Magnetic Resonance Imaging (MRI), Blood-Brain Barrier, Ischemic Stroke Original Contributions Source Type: research

Brain Ischemia Induces Diversified Neuroantigen-Specific T-Cell Responses That Exacerbate Brain Injury [Basic Sciences]
Conclusions—Our findings suggest that brain ischemia activates and diversifies T-cell responses locally, which exacerbates ischemic brain injury. (Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: Wei-Na Jin, Rayna Gonzales, Yan Feng, Kristofer Wood, Zhi Chai, Jing-Fei Dong, Antonio La Cava, Fu-Dong Shi, Qiang Liu Tags: Ischemic Stroke Original Contributions Source Type: research

Cost-Effectiveness of Left Atrial Appendage Closure With the WATCHMAN Device Compared With Warfarin or Non-Vitamin K Antagonist Oral Anticoagulants for Secondary Prevention in Nonvalvular Atrial Fibrillation [Clinical Sciences]
Conclusions—Upfront procedure costs initially make LAAC higher cost than warfarin and the non–vitamin K antagonist oral anticoagulants, but within 10 years, LAAC delivers more quality-adjusted life years and has lower total costs, making LAAC the most cost-effective treatment strategy for secondary prevention of stroke in atrial fibrillation. (Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: Vivek Y. Reddy, Ronald L. Akehurst, Stacey L. Amorosi, Meghan B. Gavaghan, Deanna S. Hertz, David R. Holmes Jr Tags: Atrial Fibrillation, Cost-Effectiveness Original Contributions Source Type: research

Long-Term Outcomes in Patients Aged
Background and Purpose—We aimed to determine whether subjects aged ≤70 years who were treated with intravenous glyburide (RP-1127; BIIB093; glibenclamide) would have better long-term outcomes than those who received placebo.Methods—GAMES-RP (Glyburide Advantage in Malignant Edema and Stroke–Remedy Pharmaceuticals) was a prospective, double-blind, randomized, placebo-controlled phase 2 clinical trial. Eighty-six participants, aged 18 to 80 years, who presented to 18 centers with large hemispheric infarction (baseline diffusion-weighted imaging volumes, 82–300 cm3) randomized within 10 hours of sym...
Source: Stroke - May 25, 2018 Category: Neurology Authors: Kevin N. Sheth, Nils H. Petersen, Ken Cheung, Jordan J. Elm, Holly E. Hinson, Bradley J. Molyneaux, Lauren A. Beslow, Gordon K. Sze, J. Marc Simard, W. Taylor Kimberly Tags: Treatment, Ischemic Stroke Original Contributions Source Type: research

Association of Blood Pressure With Short- and Long-Term Functional Outcome After Stroke Thrombectomy [Clinical Sciences]
This study aims to assess the association of BP changes during general anesthesia versus conscious sedation with functional outcome after mechanical thrombectomy.Methods—SIESTA (Sedation vs Intubation for Endovascular Stroke Treatment) was a monocentric randomized trial of general anesthesia versus conscious sedation during mechanical thrombectomy involving BP target protocols. In this post hoc analysis, BP measurements were divided into 4 phases: preintervention, prerecanalization, postrecanalization, and postintervention. We examined the association between BP and functional outcomes (defined by improvement of 24-h...
Source: Stroke - May 25, 2018 Category: Neurology Authors: Silvia Schonenberger, Lorenz Uhlmann, Matthias Ungerer, Johannes Pfaff, Simon Nagel, Christina Klose, Martin Bendszus, Wolfgang Wick, Peter A. Ringleb, Meinhard Kieser, Markus A. Mohlenbruch, Julian Bosel Tags: Ischemic Stroke Original Contributions Source Type: research

Cost-Effectiveness of Patent Foramen Ovale Closure Versus Medical Therapy for Secondary Stroke Prevention [Clinical Sciences]
Conclusions—PFO closure for cryptogenic strokes in the right setting is cost-effective, producing benefit in QALYs gained and potential cost savings. However, patient selection remains vitally important as marginal declines in treatment effectiveness can dramatically affect cost-effectiveness. (Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: Michelle H. Leppert, Sharon N. Poisson, John D. Carroll, David E. Thaler, Chong H. Kim, Karen D. Orjuela, P. Michael Ho, James F. Burke, Jonathan D. Campbell Tags: Treatment, Cost-Effectiveness, Ischemic Stroke, Embolism Original Contributions Source Type: research

Antiplatelet Treatment After Transient Ischemic Attack and Ischemic Stroke in Patients With Cerebral Microbleeds in 2 Large Cohorts and an Updated Systematic Review [Clinical Sciences]
Background and Purpose—In patients with transient ischemic attack/ischemic stroke, microbleed burden predicts intracerebral hemorrhage (ICH), and ischemic stroke, but implications for antiplatelet treatment are uncertain. Previous cohort studies have had insufficient follow-up to assess the time course of risks, have not stratified risks by antithrombotic use, and have not reported extracranial bleeds or functional outcome of ICH versus ischemic stroke.Methods—In 2 independent prospective cohorts with transient ischemic attack/ischemic stroke (Oxford Vascular Study/mainly white; University of Hong Kong/mainly C...
Source: Stroke - May 25, 2018 Category: Neurology Authors: Kui Kai Lau, Caroline E. Lovelock, Linxin Li, Michela Simoni, Sergei Gutnikov, Wilhelm Kuker, Henry Ka Fung Mak, Peter M. Rothwell Tags: Magnetic Resonance Imaging (MRI), Intracranial Hemorrhage, Ischemic Stroke, Transient Ischemic Attack (TIA) Original Contributions Source Type: research

Computed Tomographic Perfusion Predicts Poor Outcomes in a Randomized Trial of Endovascular Therapy [Clinical Sciences]
Conclusions—The majority of patients with CTP imaging in the ESCAPE trial had penumbral patterns, which were associated with better outcomes overall. Patients with penumbra treated with endovascular therapy had the greatest odds of good functional outcome. Nonpenumbral patients were much less likely to achieve good outcomes. (Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: Robert Wannamaker, Taurian Guinand, Bijoy K. Menon, Andrew Demchuk, Mayank Goyal, Donald Frei, Aditya Bharatha, Tudor G. Jovin, Jai Shankar, Timo Krings, Blaise Baxter, Christine Holmstedt, Richard Swartz, Dar Dowlatshahi, Richard Chan, Donatella Tampieri Tags: Ischemic Stroke Original Contributions Source Type: research

Delays in the Air or Ground Transfer of Patients for Endovascular Thrombectomy [Clinical Sciences]
Background and Purpose—For suspected large vessel occlusion patients efficient transfer to centers that provide endovascular therapy (ET) is critical to maximizing treatment opportunity. Our objective was to examine associations between transfer time, modes of transfer, ET, and outcomes within a hub-and-spoke telestroke network.Methods—Patients with ischemic stroke were included if transferred to a single hub hospital between January 2011 and October 2015 with National Institutes of Health Stroke Scale>6, onset (Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: Robert W. Regenhardt, Adam P. Mecca, Stephanie A. Flavin, Gregoire Boulouis, Arne Lauer, Kori Sauser Zachrison, James Boomhower, Aman B. Patel, Joshua A. Hirsch, Lee H. Schwamm, Thabele M. Leslie-Mazwi Tags: Revascularization, Quality and Outcomes, Cerebrovascular Disease/Stroke, Cerebrovascular Procedures, Ischemic Stroke Original Contributions Source Type: research

Blood Pressure-Attained Analysis of ATACH 2 Trial [Clinical Sciences]
Background and Purpose—We compared the rates of death or disability, defined by modified Rankin Scale score of 4 to 6, at 3 months in patients with intracerebral hemorrhage according to post-treatment systolic blood pressure (SBP)–attained status.Methods—We divided 1000 subjects with SBP ≥180 mm Hg who were randomized within 4.5 hours of symptom onset as follows: SBP (Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: Adnan I. Qureshi, Yuko Y. Palesch, Lydia D. Foster, William G. Barsan, Joshua N. Goldstein, Daniel F. Hanley, Chung Y. Hsu, Claudia S. Moy, Mushtaq H. Qureshi, Robert Silbergleit, Jose I. Suarez, Kazunori Toyoda, Haruko Yamamoto, on behalf of ATACH 2 Tri Tags: Statements and Guidelines, Cerebrovascular Disease/Stroke, Intracranial Hemorrhage Original Contributions Source Type: research

Clinical Utility of Electronic Alberta Stroke Program Early Computed Tomography Score Software in the ENCHANTED Trial Database [Clinical Sciences]
Background and Purpose—Clinical utility of electronic Alberta Stroke Program Early CT Score (e-ASPECTS), an automated system for quantifying signs of infarction, was evaluated in a large database of thrombolyzed patients with acute ischemic stroke.Methods—All baseline noncontrast computed tomographic scans of patients with anterior circulation acute ischemic stroke who participated in the alteplase dose arm of the randomized controlled trial ENCHANTED (Enhanced Control of Hypertension and Thrombolysis Stroke Study) were reviewed; poor quality and large (>6 mm) slice thickness were excluded. Included scans ha...
Source: Stroke - May 25, 2018 Category: Neurology Authors: Simon Nagel, Xia Wang, Cheryl Carcel, Thompson Robinson, Richard I. Lindley, John Chalmers, Craig S. Anderson Tags: Cerebrovascular Disease/Stroke, Ischemic Stroke Original Contributions Source Type: research

Magnetic Resonance Imaging Selection for Endovascular Stroke Therapy [Clinical Sciences]
Conclusions—Workflow in GOLIATH demonstrates that magnetic resonance imaging selection for endovascular therapy can be accomplished rapidly and within a similar time frame as computed tomography-based selection.Clinical Trial Registration—URL: https://www.clinicaltrials.gov. Unique identifier: NCT02317237. (Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: Claus Z. Simonsen, Albert J. Yoo, Mads Rasmussen, Kristina E. Sorensen, Thabele Leslie–Mazwi, Grethe Andersen, Leif H. Sorensen Tags: Magnetic Resonance Imaging (MRI), Revascularization, Ischemic Stroke Original Contributions Source Type: research

Prediction of Tissue Outcome and Assessment of Treatment Effect in Acute Ischemic Stroke Using Deep Learning [Clinical Sciences]
Background and Purpose—Treatment options for patients with acute ischemic stroke depend on the volume of salvageable tissue. This volume assessment is currently based on fixed thresholds and single imagine modalities, limiting accuracy. We wish to develop and validate a predictive model capable of automatically identifying and combining acute imaging features to accurately predict final lesion volume.Methods—Using acute magnetic resonance imaging, we developed and trained a deep convolutional neural network (CNNdeep) to predict final imaging outcome. A total of 222 patients were included, of which 187 were trea...
Source: Stroke - May 25, 2018 Category: Neurology Authors: Anne Nielsen, Mikkel Bo Hansen, Anna Tietze, Kim Mouridsen Tags: Magnetic Resonance Imaging (MRI), Treatment, Quality and Outcomes, Statements and Guidelines, Ischemic Stroke Original Contributions Source Type: research

Progression of White Matter Hyperintensities Preceded by Heterogeneous Decline of Microstructural Integrity [Clinical Sciences]
Conclusions—Impaired microstructural integrity preceded conversion into WMH and continuously declined over time, suggesting a continuous disease process of white matter integrity loss that can be detected using diffusion tensor imaging even years before WMH become visible on conventional neuroimaging. Differences in microstructural integrity between participants with mild versus severe WMH suggest heterogeneity of both NAWM and WMH, which might explain the clinical variability observed in patients with similar small vessel disease severity. (Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: Esther M.C. van Leijsen, Mayra I. Bergkamp, Ingeborg W.M. van Uden, Mohsen Ghafoorian, Helena M. van der Holst, David G. Norris, Bram Platel, Anil M. Tuladhar, Frank-Erik de Leeuw Tags: Etiology, Cardiovascular Disease, Magnetic Resonance Imaging (MRI), Cerebrovascular Disease/Stroke, Vascular Disease Original Contributions Source Type: research

Intravenous Recombinant Tissue-Type Plasminogen Activator [Clinical Sciences]
Conclusions—In this population, previous IVT improved functional outcome and survival at 3 months in patients treated by MT. While waiting for randomized controlled trials, this result encourages not to avoid IVT before MT. (Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: Marc Ferrigno, Nicolas Bricout, Didier Leys, Laurent Estrade, Charlotte Cordonnier, Thomas Personnic, Maeva Kyheng, Hilde Henon Tags: Cerebrovascular Disease/Stroke, Ischemic Stroke Original Contributions Source Type: research

Association of Basilar Bifurcation Aneurysms With Age, Sex, and Bifurcation Geometry [Clinical Sciences]
Background and Purpose—Basilar artery (BA) bifurcation aneurysms are common, but the correlation between BA bifurcation morphology and aneurysm formation remains to be established. Our purpose was to determine the association of BA bifurcation aneurysms with patient age, sex, bifurcation angle, and branch diameter.Methods—Three-dimensional angiographic data of 195 patients were used, including 59 patients with BA bifurcation aneurysms and 136 control subjects. The angles formed between left and right posterior cerebral arteries (φ1) and between posterior cerebral artery and BA (the smaller angle defined as ...
Source: Stroke - May 25, 2018 Category: Neurology Authors: Xue-Jing Zhang, Bu-Lang Gao, Tian-Xiao Li, Wei-Li Hao, Song-Shi Wu, Dong-Hai Zhang Tags: Basic Science Research, Cerebral Aneurysm Original Contributions Source Type: research

Perimesencephalic Hemorrhage [Clinical Sciences]
Conclusions—A single, high-quality computed tomography angiography is the preferred diagnostic strategy. Short-term complications are rare and often transient. Long-term outcome is excellent with respect to disability and death, but high-quality studies focused at neuropsychological sequelae are needed. (Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: Liselore A. Mensing, Mervyn D.I. Vergouwen, Kamil G. Laban, Ynte M. Ruigrok, Birgitta K. Velthuis, Ale Algra, Gabriel J.E. Rinkel Tags: Epidemiology, Risk Factors, Cerebrovascular Disease/Stroke Original Contributions Source Type: research

Multivessel Occlusion in Patients Subjected to Thrombectomy [Clinical Sciences]
Background and Purpose—Patients with embolic large-vessel occlusion may present with additional coincidental acute occlusions within or distant from the involved territory, referred to as multivessel occlusion (MVO). Purpose of this study was to assess prevalence of MVO, associated factors, and clinical relevance in patients undergoing endovascular stroke treatment.Methods—Image data of consecutive endovascular candidates (n=720) with direct access to angiography were extracted from a prospective registry. Prevalence of MVO was assessed with multimodal magnetic resonance imaging/computed tomography and confirme...
Source: Stroke - May 25, 2018 Category: Neurology Authors: Johannes Kaesmacher, Pascal J. Mosimann, Mattia Giarrusso, Marwan El-Koussy, Felix Zibold, Eike Piechowiak, Tomas Dobrocky, Raphael Meier, Simon Jung, Sebastian Bellwald, Marcel Arnold, Pasquale Mordasini, Urs Fischer, Jan Gralla Tags: Cerebrovascular Procedures, Ischemic Stroke Original Contributions Source Type: research

Declining Rate and Severity of Hospitalized Stroke From 2004 to 2013 [Clinical Sciences]
Background and Purpose—Stroke is a leading cause of morbidity and disability. We assessed trends in rates of hospitalized stroke and stroke severity on admission in a prospective national registry of stroke from 2004 to 2013.Methods—All 6693 acute ischemic strokes and intracerebral hemorrhage in the National Acute Stroke Israeli participants ≥20 years old were included. Data were prospectively collected in 2004 (February–March), 2007 (March–April), 2010 (April–May), and 2013 (March–April). Rates of hospitalized stroke from 2004 to 2013 were studied using generalized linear models assu...
Source: Stroke - May 25, 2018 Category: Neurology Authors: Silvia Koton, Diklah Geva, Jonathan Y. Streifler, Sagi Harnof, Yoav Pougach, Olga Azrilin, Shoshana Hadar, Natan M. Bornstein, David Tanne Tags: Cardiovascular Disease, Epidemiology, Intracranial Hemorrhage, Ischemic Stroke Original Contributions Source Type: research

Genetic Study of White Matter Integrity in UK Biobank (N=8448) and the Overlap With Stroke, Depression, and Dementia [Clinical Sciences]
Conclusions—Genetic variants within the VCAN gene may play a role in the mechanisms underlying microstructural integrity of the white matter in the brain measured as FA and MD. Mechanisms underlying white matter alterations are shared with cerebrovascular disease, and inherited differences in white matter microstructure impact on Alzheimer disease and major depressive disorder. (Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: Loes C.A. Rutten-Jacobs, Daniel J. Tozer, Marco Duering, Rainer Malik, Martin Dichgans, Hugh S. Markus, Matthew Traylor Tags: Genetic, Association Studies, Magnetic Resonance Imaging (MRI), Cerebrovascular Disease/Stroke Original Contributions Source Type: research

Longitudinal Change of Perceived Salt Intake and Stroke Risk in a Chinese Population [Clinical Sciences]
Conclusions—Change in salt intake was associated with the stroke risk. These data support the dietary recommendation to the reduction of salt intake. (Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: Yun Li, Zhe Huang, Cheng Jin, Aijun Xing, Yesong Liu, Chunmei Huangfu, Alice H. Lichtenstein, Katherine L. Tucker, Shouling Wu, Xiang Gao Tags: Diet and Nutrition, Epidemiology, Lifestyle, Risk Factors, Cerebrovascular Disease/Stroke Original Contributions Source Type: research

Causal Impact of Type 2 Diabetes Mellitus on Cerebral Small Vessel Disease [Clinical Sciences]
Conclusions—Our Mendelian randomization study provides evidence to suggest that T2D may be causally associated with CSVD, in particular with lacunar stroke and FA. (Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: Junfeng Liu, Loes Rutten-Jacobs, Ming Liu, Hugh S. Markus, Matthew Traylor Tags: Genetic, Association Studies, Cerebrovascular Disease/Stroke Original Contributions Source Type: research

Population-Based Assessment of the Long-Term Risk of Seizures in Survivors of Stroke [Clinical Sciences]
Background and Purpose—We sought to determine the long-term risk of seizures after stroke according to age, sex, race, and stroke subtype.Methods—We performed a retrospective cohort study using administrative claims from 2 complementary patient data sets. First, we analyzed data from all emergency department visits and hospitalizations in California, Florida, and New York from 2005 to 2013. Second, we evaluated inpatient and outpatient claims from a nationally representative 5% random sample of Medicare beneficiaries. Our cohort consisted of all adults at the time of acute stroke hospitalization without a prior...
Source: Stroke - May 25, 2018 Category: Neurology Authors: Alexander E. Merkler, Gino Gialdini, Michael P. Lerario, Neal S. Parikh, Nicholas A. Morris, Benjamin Kummer, Lauren Dunn, Michael E. Reznik, Santosh B. Murthy, Babak B. Navi, Zachary M. Grinspan, Costantino Iadecola, Hooman Kamel Tags: Risk Factors, Cerebrovascular Disease/Stroke Original Contributions Source Type: research

Stroke: Highlights of Selected Articles [Stroke: Highlights of Selected Articles]
(Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Tags: Cerebrovascular Disease/Stroke, Ischemic Stroke, Transient Ischemic Attack (TIA) Stroke: Highlights of Selected Articles Source Type: research

Secondary Stroke Prevention in Atrial Fibrillation [Editorials]
(Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: M. Edip Gurol Tags: Atrial Fibrillation, Secondary Prevention, Cerebrovascular Disease/Stroke Editorial Source Type: research

Correction to: 2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association [Corrections]
(Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Tags: Correction Source Type: research

Response by Lee et al to Letter Regarding Article, “Predictive Value of Pulse Pressure in Acute Ischemic Stroke for Future Maȷor Vascular Events” [Letter to the Editor]
(Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: Keon-Joo Lee, Juneyoung Lee, Hee-Joon Bae Tags: Ischemic Stroke Letters to the Editor Source Type: research

Letter by Bhargava Regarding Article, “Predictive Value of Pulse Pressure in Acute Ischemic Stroke for Future Maȷor Vascular Events” [Letter to the Editor]
(Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: Alok Bhargava Tags: Epidemiology Letters to the Editor Source Type: research

Response by Oppenheim et al to Letter Regarding Article, “Outcome After Reperfusion Therapies in Patients With Large Baseline Diffusion-Weighted Imaging Stroke Lesions: A THRACE Trial (Mechanical Thrombectomy After Intravenous Alteplase Versus Alteplase Alone After Stroke) Subgroup Analysis” [Letter to the Editor]
(Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: Catherine Oppenheim, Serge Bracard, Francis Guillemin Tags: Magnetic Resonance Imaging (MRI), Prognosis, Treatment, Ischemic Stroke Letters to the Editor Source Type: research

Letter by Niu et al Regarding Article, “Outcome After Reperfusion Therapies in Patients With Large Baseline Diffusion-Weighted Imaging Stroke Lesions: A THRACE Trial (Mechanical Thrombectomy After Intravenous Alteplase Versus Alteplase Alone After Stroke) Subgroup Analysis” [Letter to the Editor]
(Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: Peng-Peng Niu, Bo Song, Yu-Ming Xu Tags: Cerebrovascular Disease/Stroke, Ischemic Stroke Letters to the Editor Source Type: research

More Than Meets the Eye [Illustrative Teaching Case]
(Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: Sneha Jacob, Amelia Adcock, Ann Murray, Joanna Kolodney Tags: Cerebrovascular Disease/Stroke, Cognitive Impairment, Ischemic Stroke, Transient Ischemic Attack (TIA) Illustrative Teaching Cases Source Type: research

Diagnosis and Management of Active Intracranial Atherosclerotic Disease [Illustrative Teaching Case]
(Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: Priya Narwal, Shawna Cutting, Shyam Prabhakaran, Shadi Yaghi Tags: Cerebrovascular Disease/Stroke Illustrative Teaching Cases Source Type: research