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Condition: Hypothermia

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Total 450 results found since Jan 2013.

Cardiovascular effects of levosimendan during rewarming from hypothermia in rat.
CONCLUSION: The present data shows that levosimendan ameliorates hypothermia-induced systolic dysfunction by elevating SV during rewarming from 15°C. Inotropic treatment during rewarming from hypothermia in the present rat model is therefore better achieved through calcium sensitizing and PDE3 inhibition, than β-receptor stimulation. PMID: 25280932 [PubMed - as supplied by publisher]
Source: Cryobiology - September 30, 2014 Category: Biology Authors: Dietrichs ES, Håheim B, Kondratiev T, Sieck GC, Tveita T Tags: Cryobiology Source Type: research

Multimodality Monitoring, Inflammation, and Neuroregeneration in Subarachnoid Hemorrhage
This study may reveal correlations between markers of inflammation and neurogenesis in blood and cerebrospinal fluid, based on clinical and multimodality monitoring parameters. DISCUSSION: This protocol has the potential to lead to new therapies for acute, diffuse, and severe brain diseases. ABBREVIATIONS: BBB, blood-brain barrier CPP, cerebral perfusion pressure EEG, electroencephalography ICP, intracranial pressure IL, interleukin MCA, middle cerebral artery SAH, subarachnoid hemorrhage SD, spreading depression SGZ, subgranular zone SVZ, subventricular zone TCD, transcranial Doppler
Source: Neurosurgery - November 20, 2014 Category: Neurosurgery Tags: Research-Human-Study Protocols Source Type: research

Cooling for cerebral protection during brain surgery.
CONCLUSIONS: We found no evidence that the use of induced hypothermia was associated with a significant reduction in mortality or severe neurological disability, or an increase in harm in patients undergoing neurosurgery. PMID: 25626888 [PubMed - in process]
Source: Cochrane Database of Systematic Reviews - February 3, 2015 Category: Journals (General) Authors: Galvin IM, Levy R, Boyd JG, Day AG, Wallace MC Tags: Cochrane Database Syst Rev Source Type: research

Systolic left ventricular function is preserved during therapeutic hypothermia, also during increases in heart rate with impaired diastolic filling
Conclusions: Systolic function was maintained at physiological heart rates during therapeutic hypothermia. Reduced tolerance to increases in heart rate was caused by lack of ventricular filling due to diastolic dysfunction and shorter diastolic duration.
Source: Intensive Care Medicine Experimental - February 24, 2015 Category: Surgery Authors: Viesturs KeransAndreas EspinozaHelge SkulstadPer HalvorsenThor EdvardsenJan Bugge Source Type: research

Rewarming Rate During Cardiopulmonary Bypass Is Associated With Release of Glial Fibrillary Acidic Protein
Conclusions Rewarming rate during CPB was correlated with evidence of brain cellular injury documented with plasma GFAP levels. Modifying current practices of patient rewarming might provide a strategy to reduce the frequency of neurologic complications after cardiac surgery.
Source: The Annals of Thoracic Surgery - July 7, 2015 Category: Cardiovascular & Thoracic Surgery Source Type: research

Rewarming Rate During Cardiopulmonary Bypass Is Associated With Release of Glial Fibrillary Acidic Protein.
CONCLUSIONS: Rewarming rate during CPB was correlated with evidence of brain cellular injury documented with plasma GFAP levels. Modifying current practices of patient rewarming might provide a strategy to reduce the frequency of neurologic complications after cardiac surgery. PMID: 26163357 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - July 7, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Hori D, Everett AD, Lee JK, Ono M, Brown CH, Shah AS, Mandal K, Price JE, Lester LC, Hogue CW Tags: Ann Thorac Surg Source Type: research

Intraoperative Electroencephalogram‐Guided Deep Hypothermia Plus Antegrade and/or Retrograde Cerebral Perfusion During Aortic Arch Surgery
ConclusionsIntraoperative EEG is a reliable monitoring tool for safe circulatory arrest.
Source: Journal of Cardiac Surgery - February 1, 2016 Category: Cardiovascular & Thoracic Surgery Authors: Takashi Murashita, Alberto Pochettino Tags: Original Article Source Type: research

Straight incision for extended descending and thoracoabdominal aortic replacement: novel and simple exposure with rib-cross thoracotomy
CONCLUSIONS This new exposure with straight incision with rib-cross thoracotomy provided excellent exposures for the long segment of the thoracoabdominal aorta, and it enabled extended replacement from the ascending aorta to the abdominal aorta.
Source: Interactive CardioVascular and Thoracic Surgery - August 21, 2016 Category: Cardiovascular & Thoracic Surgery Authors: Minatoya, K., Seike, Y., Itonaga, T., Oda, T., Inoue, Y., Kawamoto, N., Miura, S., Tanaka, H., Sasaki, H., Kobayashi, J. Tags: Pericardium, Vascular malformations Adult Cardiac Source Type: research

Hypothermia and Selective Antegrade Cerebral Perfusion Is Safe for Arch Repair in Type A Dissection.
CONCLUSIONS: Unilateral selective antegrade cerebral perfusion with moderate hypothermic circulatory arrest remains a safe strategy for cerebral protection during emergent surgical repair of acute type A dissection and provides equivalent outcomes for both limited and extensive aortic arch reconstruction. Based on these data, unilateral selective antegrade cerebral perfusion and moderate hypothermic circulatory arrest may represent an optimal strategy for cerebral protection in this acute setting. PMID: 28551049 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - May 24, 2017 Category: Cardiovascular & Thoracic Surgery Authors: Keeling WB, Leshnower BG, Hunting JC, Binongo J, Chen EP Tags: Ann Thorac Surg Source Type: research

Hypothermia and Selective Antegrade Cerebral Perfusion Is Safe for Arch Repair in Type A Dissection
Conclusions Unilateral selective antegrade cerebral perfusion with moderate hypothermic circulatory arrest remains a safe strategy for cerebral protection during emergent surgical repair of acute type A dissection and provides equivalent outcomes for both limited and extensive aortic arch reconstruction. Based on these data, unilateral selective antegrade cerebral perfusion and moderate hypothermic circulatory arrest may represent an optimal strategy for cerebral protection in this acute setting.
Source: The Annals of Thoracic Surgery - August 25, 2017 Category: Cardiovascular & Thoracic Surgery Source Type: research

Inflammatory cytokines are involved in dihydrocapsaicin (DHC) and regional cooling infusion (RCI)-induced neuroprotection in ischemic rat.
CONCLUSIONS: The combination approach enhanced the efficacy of hypothermia-induced neuroprotection following ischemic stroke. Our findings provide a hint to translate the combination method from bench to bedside. PMID: 30584925 [PubMed - as supplied by publisher]
Source: Brain Research - December 22, 2018 Category: Neurology Authors: Wu D, Zhi X, Duan Y, Zhang M, An H, Wei W, Dong K, Zhang Y, Shi J, He X, Zhang J, Wu C, Meng R, Ding Y, Ji X Tags: Brain Res Source Type: research

Drug development in targeting ion channels for brain edema.
Abstract Cerebral edema is a pathological hallmark of various central nervous system (CNS) insults, including traumatic brain injury (TBI) and excitotoxic injury such as stroke. Due to the rigidity of the skull, edema-induced increase of intracranial fluid significantly complicates severe CNS injuries by raising intracranial pressure and compromising perfusion. Mortality due to cerebral edema is high. With mortality rates up to 80% in severe cases of stroke, it is the leading cause of death within the first week. Similarly, cerebral edema is devastating for patients of TBI, accounting for up to 50% mortality. Curr...
Source: Acta Pharmacologica Sinica - August 26, 2020 Category: Drugs & Pharmacology Authors: Luo ZW, Ovcjak A, Wong R, Yang BX, Feng ZP, Sun HS Tags: Acta Pharmacol Sin Source Type: research

The Complex Relationship Between Cooling Parameters and Neuroprotection in a Model of Selective Hypothermia
ConclusionsIn a large animal model of selective hypothermia applied to focal ischemia, there is a non-monotone relationship between duration and depth of hypothermia and stroke volume reduction. This suggests a limit to depth or duration of selective hypothermia for optimal neuroprotection. Further research is required to delineate more precise depth and duration limits for selective hypothermia.
Source: Frontiers in Neurology - April 25, 2022 Category: Neurology Source Type: research

Temperature Management in the ICU
CONCLUSIONS: Body temperature management in critically ill patients remains an appealing therapy for several illnesses, and additional studies are needed to clarify management strategies and therapeutic pathways.
Source: Critical Care Medicine - June 24, 2022 Category: Emergency Medicine Tags: Concise Definitive Review Source Type: research

Errors in Secondary Outcomes
This article was corrected online.
Source: JAMA - April 11, 2023 Category: General Medicine Source Type: research