New automated analysis to monitor neutrophil function point-of-care in the intensive care unit after trauma
Patients often develop infectious complications after severe trauma. No biomarkers exist that enable early identification of patients who are at risk. Neutrophils are important immune cells that combat these i... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - March 14, 2020 Category: Surgery Authors: Lillian Hesselink, Roy Spijkerman, Emma de Fraiture, Suzanne Bongers, Karlijn J. P. Van Wessem, Nienke Vrisekoop, Leo Koenderman, Luke P. H. Leenen and Falco Hietbrink Tags: Research Source Type: research

Update of the organoprotective properties of xenon and argon: from bench to beside
The growth of the elderly population has led to an increase in patients with myocardial infarction and stroke (Wajngarten and Silva, Eur Cardiol 14: 111 –115, 2019). Patients receiving treatment for ST-segment-... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - February 24, 2020 Category: Surgery Authors: Roehl Anna, Rossaint Rolf and Coburn Mark Tags: Review Source Type: research

Real-time effects of PEEP and tidal volume on regional ventilation and perfusion in experimental lung injury
Real-time bedside information on regional ventilation and perfusion during mechanical ventilation (MV) may help to elucidate the physiological and pathophysiological effects of MV settings in healthy and injur... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - February 21, 2020 Category: Surgery Authors: Jo ão Batista Borges, John N. Cronin, Douglas C. Crockett, Göran Hedenstierna, Anders Larsson and Federico Formenti Tags: Research Source Type: research

Time-dependent effects of histone deacetylase inhibition in sepsis-associated acute kidney injury
Sepsis, a dysregulated host response to infection with results in organ dysfunction, has been a major challenge to the development of effective therapeutics. Sepsis-associated acute kidney injury (S-AKI) resul... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - February 7, 2020 Category: Surgery Authors: Xiaoyan Wen, Shengnan Li, Alicia Frank, Xiukai Chen, David Emlet, Neil A. Hukriede and John A. Kellum Tags: Research Source Type: research

Cytokine pre-activation of cryopreserved xenogeneic-free human mesenchymal stromal cells enhances resolution and repair following ventilator-induced lung injury potentially via a KGF-dependent mechanism
Human mesenchymal stem/stromal cells (hMSCs) represent a promising therapeutic strategy for ventilator-induced lung injury (VILI) and acute respiratory distress syndrome. Translational challenges include resto... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - February 5, 2020 Category: Surgery Authors: Shahd Horie, Sean Gaynard, Mary Murphy, Frank Barry, Michael Scully, Daniel O ’Toole and John G. Laffey Tags: Research Source Type: research

Checkpoint inhibitor therapy in preclinical sepsis models: a systematic review and meta-analysis
Animal studies reporting immune checkpoint inhibitors (CPIs) improved host defense and survival during bacterial sepsis provided one basis for phase I CPI sepsis trials. We performed a systematic review and me... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - February 4, 2020 Category: Surgery Authors: Lindsay M. Busch, Junfeng Sun, Xizhong Cui, Peter Q. Eichacker and Parizad Torabi-Parizi Tags: Research Source Type: research

Emerging pharmacological tools to control hydrogen sulfide signaling in critical illness
Hydrogen sulfide (H2S) has long been known as a toxic environmental hazard. Discovery of physiological roles of H2S as a neurotransmitter by Kimura and colleagues triggered an intensive research in the biological... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - January 31, 2020 Category: Surgery Authors: Eizo Marutani and Fumito Ichinose Tags: Review Source Type: research

In vitro comparison between inspiration synchronized and continuous vibrating mesh nebulizer during trans-nasal aerosol delivery
Compared to continuous vibrating mesh nebulizer (VMN), inspiration synchronized VMN has shown increased inhaled dose during noninvasive ventilation; however, its use during aerosol delivery via high-flow nasal... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - January 31, 2020 Category: Surgery Authors: Jie Li, Wei Wu and James B. Fink Tags: Research Source Type: research

Correction to: A case of intracoronary and endovenous levosimendan as a rescue therapy for refractory cardiac arrest
After publication of this supplement [1], it was brought to our attention that the author ‘L. Vegnuti’ has been erroneously omitted from the author list of the following abstract. (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - January 21, 2020 Category: Surgery Authors: B. Ferro, R. Tofani, L. Vegnuti, G. Borelli, L. Gargani and P. Roncucci Tags: Correction Source Type: research

Meta-analysis of targeted temperature management in animal models of cardiac arrest
Targeted temperature management (TTM) of 32 to 34  °C has been the standard treatment for out-of-hospital cardiac arrest since clinical trials in 2002 indicated benefit on survival and neurological outcome. In ... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - January 17, 2020 Category: Surgery Authors: Hilmer Olai, Gustav Thorn éus, Hannah Watson, Malcolm Macleod, Jonathan Rhodes, Hans Friberg, Niklas Nielsen, Tobias Cronberg and Tomas Deierborg Tags: Research Source Type: research

Carbon monoxide in intensive care medicine —time to start the therapeutic application?!
Carbon monoxide (CO) is not only known as a toxic gas due to its characteristics as an odorless molecule and its rapid binding to haem-containing molecules, thus inhibiting the respiratory chain in cells resul... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - January 9, 2020 Category: Surgery Authors: Ulrich Goebel and Jakob Wollborn Tags: Review Source Type: research

Aortic volume determines global end-diastolic volume measured by transpulmonary thermodilution
Global end-diastolic volume (GEDV) measured by transpulmonary thermodilution is regarded as indicator of cardiac preload. A bolus of cold saline injected in a central vein travels through the heart and lung, b... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - January 2, 2020 Category: Surgery Authors: Aleksej Akohov, Christoph Barner, Steffen Grimmer, Roland CE Francis and Stefan Wolf Tags: Research Source Type: research

Intracellular calcium signaling and phospho-antigen measurements reveal functional proximal TCR activation in lymphocytes from septic shock patients
(Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - December 23, 2019 Category: Surgery Authors: Charles de Roquetaillade, Khalil Kandara, Morgane Gossez, Estelle Peronnet, C éline Monard, Martin Cour, Thomas Rimmelé, Laurent Argaud, Guillaume Monneret and Fabienne Venet Tags: Letter to the Editor Source Type: research

Gaseous mediators: an updated review on the effects of helium beyond blowing up balloons
Noble gases, although supposed to be chemically inert, mediate numerous physiological and cellular effects, leading to protection against ischaemia-reperfusion injury in different organs. Clinically, the noble... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - December 19, 2019 Category: Surgery Authors: Nina C. Weber and Benedikt Preckel Tags: Review Source Type: research

Selenium and hydrogen selenide: essential micronutrient and the fourth gasotransmitter?
Selenium (Se) is an essential micronutrient required by organisms of diverse lineage. Dietary Se is converted to hydrogen selenide either enzymatically or by endogenous antioxidant proteins. This convergent bi... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - December 16, 2019 Category: Surgery Authors: Mathun Kuganesan, Kavitej Samra, Eloise Evans, Mervyn Singer and Alex Dyson Tags: Review Source Type: research

Four hours of veno-venous extracorporeal membrane oxygenation using bi-caval cannulation affects kidney function and induces moderate lung damage in a mouse model
Improvement of single site cannulation for extracorporeal membrane oxygenation (ECMO) therapy is pivotal for reduction of patient morbidity and mortality in respiratory failure. To further improve the cardiopu... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - December 16, 2019 Category: Surgery Authors: Ruslan Natanov, Abdurasul Khalikov, Faikah Gueler, Ulrich Maus, Erin C. Boyle, Axel Haverich, Christian K ühn and Nodir Madrahimov Tags: Research Source Type: research

Ethical considerations about artificial intelligence for prognostication in intensive care
Prognosticating the course of diseases to inform decision-making is a key component of intensive care medicine. For several applications in medicine, new methods from the field of artificial intelligence (AI) ... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - December 10, 2019 Category: Surgery Authors: Michael Beil, Ingo Proft, Daniel van Heerden, Sigal Sviri and Peter Vernon van Heerden Tags: Review Source Type: research

Report of the first AKI Round Table meeting: an initiative of the ESICM AKI Section
Critical Care Nephrology is an emerging sub-specialty of Critical Care. Despite increasing awareness about the serious impact of acute kidney injury (AKI) and renal replacement therapy (RRT), important knowled... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - December 7, 2019 Category: Surgery Authors: M. Ostermann, A. Schneider, T. Rimmele, I. Bobek, M. van Dam, M. Darmon, L. Forni, O. Joannes-Boyau, M. Joannidis, M. Legrand, J. Prowle, A. Zarbock and E. Hoste Tags: Methodology Source Type: research

Methane and Inflammation - A Review (Fight Fire with Fire)
Mammalian methanogenesis is regarded as an indicator of carbohydrate fermentation by anaerobic gastrointestinal flora. Once generated by microbes or released by a non-bacterial process, methane is generally co... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - December 5, 2019 Category: Surgery Authors: Marietta Zita Poles, L ászló Juhász and Mihály Boros Tags: Review Source Type: research

Moderately prolonged permissive hypotension results in reversible metabolic perturbation evaluated by intracerebral microdialysis - an experimental animal study
Damage control resuscitation (DCR) and damage control surgery (DCS) is the main strategy in patients with uncontrollable hemorrhagic shock. One aspect of DCR is permissive hypotension. However, the duration of... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - December 4, 2019 Category: Surgery Authors: Rasmus Peter Jakobsen, Troels Halfeld Nielsen, Simon M ølstrøm, Carl-Henrik Nordström, Asger Granfeldt and Palle Toft Tags: Research Source Type: research

Esmolol for cardioprotection during resuscitation with adrenaline in an ischaemic porcine cardiac arrest model
The effectiveness of adrenaline during resuscitation continues to be debated despite being recommended in international guidelines. There is evidence that the β-adrenergic receptor (AR) effects of adrenaline a... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - December 4, 2019 Category: Surgery Authors: Hilde Karlsen, Harald Arne Bergan, Per Steinar Halvorsen, Kjetil Sunde, Eirik Qvigstad, Geir Øystein Andersen, Jan Frederik Bugge and Theresa Mariero Olasveengen Tags: Research Source Type: research

Correction to: Impact of intensive care unit supportive care on the physiology of Ebola virus disease in a universally lethal non-human primate model
Please note that four authors (Logan Banadyga, Alixandra Albietz, Brad Pickering, and Gary Wong) have been erroneously omitted from the author list in the published original article [1]. (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - December 4, 2019 Category: Surgery Authors: Guillaume Poliquin, Duane Funk, Shane Jones, Kaylie Tran, Charlene Ranadheera, Mable Hagan, Kevin Tierney, Allen Grolla, Amrinder Dhaliwal, Alexander Bello, Anders Leung, Cory Nakamura, Darwyn Kobasa, Darryl Falzarano, Lauren Garnett, Hugues Fausther Bove Tags: Correction Source Type: research

Combination of cardiac and thoracic pump theories in rodent cardiopulmonary resuscitation: a new method of three-side chest compression
High-quality cardiopulmonary resuscitation (HQ-CPR) is of paramount importance to improve neurological outcomes of cardiac arrest (CA). The purpose of this study was to evaluate chest compression methods by co... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - December 2, 2019 Category: Surgery Authors: Yu Okuma, Koichiro Shinozaki, Tsukasa Yagi, Kota Saeki, Tai Yin, Junhwan Kim and Lance B. Becker Tags: Research Source Type: research

Needle-free connectors catheter-related bloodstream infections: a prospective randomized controlled trial
In the critically ill, catheter-related bloodstream infection can result from bacterial contamination of infusion hubs of intravascular catheters. Needle-free connectors (NFC) have been suggested to reduce the... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - December 2, 2019 Category: Surgery Authors: Michael Koeppen, Franziska Weinert, Sabrina Oehlschlaeger, Andreas Koerner, Peter Rosenberger and Helene Anna Haeberle Tags: Research Source Type: research

Bench to bedside review: therapeutic modulation of nitric oxide in sepsis —an update
Nitric oxide is a signalling molecule with an extensive range of functions in both health and disease. Discovered in the 1980s through work that earned the Nobel prize, nitric oxide is an essential factor in r... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - December 2, 2019 Category: Surgery Authors: Simon Lambden Tags: Review Source Type: research

Mechanical power at a glance: a simple surrogate for volume-controlled ventilation
Mechanical power is a summary variable including all the components which can possibly cause VILI (pressures, volume, flow, respiratory rate). Since the complexity of its mathematical computation is one of the... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - November 27, 2019 Category: Surgery Authors: Lorenzo Giosa, Mattia Busana, Iacopo Pasticci, Matteo Bonifazi, Matteo Maria Macr ì, Federica Romitti, Francesco Vassalli, Davide Chiumello, Michael Quintel, J. J. Marini and Luciano Gattinoni Tags: Research Source Type: research

Increased effort during partial ventilatory support is not associated with lung damage in experimental acute lung injury
An on-going debate exists as to whether partial ventilatory support is lung protective in an acute phase of ARDS. So far, the effects of different respiratory efforts on the development of ventilator-associate... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - November 5, 2019 Category: Surgery Authors: Dietrich Henzler, Alf Schmidt, Zhaolin Xu, Nada Ismaiel, Haibo Zhang, Arthur S. Slutsky and Paolo Pelosi Tags: Research Source Type: research

Dynamic single-slice CT estimates whole-lung dual-energy CT variables in pigs with and without experimental lung injury
Dynamic single-slice CT (dCT) is increasingly used to examine the intra-tidal, physiological variation in aeration and lung density in experimental lung injury. The ability of dCT to predict whole-lung values ... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - November 1, 2019 Category: Surgery Authors: John N. Cronin, Jo ão Batista Borges, Douglas C. Crockett, Andrew D. Farmery, Göran Hedenstierna, Anders Larsson, Minh C. Tran, Luigi Camporota and Federico Formenti Tags: Research Source Type: research

Increased mortality in elderly patients with acute respiratory distress syndrome is not explained by host response
Advanced age is associated with increased mortality in acute respiratory distress syndrome (ARDS) patients. Preclinical studies suggest that the host response to an injurious challenge is age-dependent. In ARD... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - October 29, 2019 Category: Surgery Authors: Laura R. A. Schouten, Lieuwe D. J. Bos, A. Serpa Neto, Lonneke A. van Vught, Maryse A. Wiewel, Arie J. Hoogendijk, Marc J. M. Bonten, Olaf L. Cremer, Janneke Horn, Tom van der Poll, Marcus J. Schultz and Roelie M. W östen-van Asperen Tags: Research Source Type: research

The peripheral blood transcriptome in septic cardiomyopathy: an observational, pilot study
Septic cardiomyopathy (SCM) is common in sepsis and associated with increased morbidity and mortality. Left ventricular global longitudinal strain (LV GLS), measured by speckle tracking echocardiography, allow... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - October 24, 2019 Category: Surgery Authors: Meghan M. Cirulis, Sarah J. Beesley, Emily L. Wilson, Chris Stubben, Troy D. Olsen, Eliotte L. Hirshberg, Lane M. Smith, Michael J. Lanspa, Theodore P. Abraham, Colin K. Grissom, Matthew T. Rondina and Samuel M. Brown Tags: Research Source Type: research

Esicm lives 2019
(Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - September 27, 2019 Category: Surgery Tags: Meeting abstracts Source Type: research

Respiratory and metabolic acidosis correction with the ADVanced Organ Support system
The lung, the kidney, and the liver are major regulators of acid-base balance. Acidosis due to the dysfunction of one or more organs can increase mortality, especially in critically ill patients. Supporting co... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - September 18, 2019 Category: Surgery Authors: Aritz Perez Ruiz de Garibay, John A. Kellum, Johannes Honigschnabel and Bernhard Kreymann Tags: Research Source Type: research

Impact of intensive care unit supportive care on the physiology of Ebola virus disease in a universally lethal non-human primate model
There are currently limited data for the use of specific antiviral therapies for the treatment of Ebola virus disease (EVD). While there is anecdotal evidence that supportive care may be effective, there is a ... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - September 13, 2019 Category: Surgery Authors: Guillaume Poliquin, Duane Funk, Shane Jones, Kaylie Tran, Charlene Ranadheera, Mable Hagan, Kevin Tierney, Allen Grolla, Amrinder Dhaliwal, Alexander Bello, Anders Leung, Cory Nakamura, Darwyn Kobasa, Darryl Falzarano, Lauren Garnett, Hugues Fausther Bove Tags: Research Source Type: research

Peroxynitrite decomposition catalyst reduces vasopressin requirement in ovine MRSA sepsis
This study tested the hy... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - September 9, 2019 Category: Surgery Authors: Osamu Fujiwara, Satoshi Fukuda, Ernesto Lopez, Yaping Zeng, Yosuke Niimi, Douglas S. DeWitt, David N. Herndon, Donald S. Prough and Perenlei Enkhbaatar Tags: Research Source Type: research

Determining rhythmicity and determinism of temperature curves in septic and non-septic critically ill patients through chronobiological and recurrence quantification analysis: a pilot study
A few studies have demonstrated that critically ill patients exhibit circadian deregulation and reduced complexity of different time series, such as temperature. (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - September 5, 2019 Category: Surgery Authors: Vasilios E. Papaioannou, Eleni N. Sertaridou, Ioanna G. Chouvarda, George C. Kolios and Ioannis N. Pneumatikos Tags: Research Source Type: research

The impact of the systemic inflammatory response on hepatic bacterial elimination in experimental abdominal sepsis
Bacterial translocation from the gut has been suggested to induce a systemic inflammatory response syndrome (SIRS) and organ dysfunction. The liver has a pivotal role in eliminating circulating bacteria enteri... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - August 27, 2019 Category: Surgery Authors: Katja Hanslin, Jan Sj ölin, Paul Skorup, Frida Wilske, Robert Frithiof, Anders Larsson, Markus Castegren, Eva Tano and Miklos Lipcsey Tags: Research Source Type: research

Predictive validity of a novel non-invasive estimation of effective shunt fraction in critically ill patients
Accurate measurement of pulmonary oxygenation is important for classification of disease severity and quantification of outcomes in clinical studies. Currently, tension-based methods such as P/F ratio are in w... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - August 20, 2019 Category: Surgery Authors: Emma M. Chang, Andrew Bretherick, Gordon B. Drummond and J Kenneth Baillie Tags: Research Source Type: research

Low flow rate alters haemostatic parameters in an ex-vivo extracorporeal membrane oxygenation circuit
Extracorporeal membrane oxygenation (ECMO) is a life-saving modality used to manage cardiopulmonary failure refractory to conventional medical and surgical therapies. Despite advances in ECMO equipment, bleedi... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - August 20, 2019 Category: Surgery Authors: Katrina K. Ki, Margaret R. Passmore, Chris H. H. Chan, Maximilian V. Malfertheiner, Jonathon P. Fanning, Mah é Bouquet, Jonathan E. Millar, John F. Fraser and Jacky Y. Suen Tags: Research Source Type: research

Effect of landiolol on sex-related transcriptomic changes in the myocardium during sepsis
The aims of this study are to better understand phenotypic differences between male and female rats during sepsis, to characterise the contribution of the beta1-adrenergic blocker landiolol to septic cardiomyo... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - August 19, 2019 Category: Surgery Authors: Thi Thom Tran, Calypso Mathieu, Magali Torres, B éatrice Loriod, Linh Thuy Lê, Catherine Nguyen, Monique Bernard, Marc Leone and Nathalie Lalevée Tags: Research Source Type: research

Pulmonary complement depositions in autopsy of critically ill patients have no relation with ARDS
The complement system has frequently been suggested to play a role in the pathophysiology of acute respiratory distress syndrome (ARDS). The current study explored the association between pulmonary depositions... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - July 25, 2019 Category: Surgery Authors: Friso M. de Beer, Mark P. V. Begieneman, Joris J. T. H. Roelofs, Janneke Horn, Hans W. M. Niessen, Marcus J. Schultz and Wim K. Lagrand Tags: Research Source Type: research

Power to mechanical power to minimize ventilator-induced lung injury?
Mechanical ventilation is a life-supportive therapy, but can also promote damage to pulmonary structures, such as epithelial and endothelial cells and the extracellular matrix, in a process referred to as vent... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - July 25, 2019 Category: Surgery Authors: Pedro Leme Silva, Lorenzo Ball, Patricia R. M. Rocco and Paolo Pelosi Tags: Review Source Type: research

Use of a high platelet-to-RBC ratio of 2:1 is more effective in correcting trauma-induced coagulopathy than a ratio of 1:1 in a rat multiple trauma transfusion model
Platelet dysfunction importantly contributes to trauma-induced coagulopathy (TIC). Our aim was to examine the impact of transfusing platelets (PLTs) in a 2:1 PLT-to-red blood cell (RBC) ratio versus the standa... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - July 25, 2019 Category: Surgery Authors: Derek J. B. Kleinveld, Mathijs R. Wirtz, Daan P. van den Brink, M. Adrie W. Maas, Joris J. T. H. Roelofs, J. Carel Goslings, Markus W. Hollmann and Nicole P. Juffermans Tags: Research Source Type: research

The diagnostic accuracy for ARDS of global versus regional lung ultrasound scores - a post hoc analysis of an observational study in invasively ventilated ICU patients
Semi-quantification of lung aeration by ultrasound helps to assess presence and extent of pulmonary pathologies, including the acute respiratory distress syndrome (ARDS). It is uncertain which lung regions add... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - July 25, 2019 Category: Surgery Authors: Luigi Pisani, Veronica Vercesi, Patricia S. I. van Tongeren, Wim K. Lagrand, Stije J. Leopold, Mischa A. M. Huson, Patricia C. Henwood, Andrew Walden, Marry R. Smit, Elisabeth D. Riviello, Paolo Pelosi, Arjen M. Dondorp and Marcus J. Schultz Tags: Research Source Type: research

Development of a model for anemia of inflammation that is relevant to critical care
Anemia of inflammation (AI) is common in critically ill patients. Although this syndrome negatively impacts the outcome of critical illness, understanding of its pathophysiology is limited. Also, new therapies... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - July 25, 2019 Category: Surgery Authors: Margit Boshuizen, Robin van Bruggen, Sebastian A. Zaat, Marcus J. Schultz, Eli Aguilera, Ana Motos, Tarek Senussi, Francesco Antonio Idone, Paolo Pelosi, Antonio Torres, Gianluigi Li Bassi and Nicole P. Juffermans Tags: Research Source Type: research

Sepsis 2019
(Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - June 27, 2019 Category: Surgery Tags: Meeting Abstracts Source Type: research

Alleviation of exhaustion-induced immunosuppression and sepsis by immune checkpoint blockers sequentially administered with antibiotics —analysis of a new mathematical model
Sepsis-associated immune dysregulation, involving hyper-inflammation and immunosuppression, is common in intensive care patients, often leading to multiple organ dysfunction and death. The aim of this study wa... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - June 11, 2019 Category: Surgery Authors: Avi Gillis, Michael Beil, Karin Halevi-Tobias, Peter Vernon van Heerden, Sigal Sviri and Zvia Agur Tags: Research Source Type: research

Response to letter by Drs. Bottinger and van der Hoorn
(Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - June 6, 2019 Category: Surgery Authors: David A. Berlin, Seth Manoach and Paul M. Heerdt Tags: Letter to the Editor Source Type: research

Resistin directly inhibits bacterial killing in neutrophils
Sepsis-induced immunosuppression is a key factor contributing to the morbidity and mortality of critically ill patients, and polymorphonuclear neutrophil dysfunction is believed to be a hallmark of this immuno... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - May 30, 2019 Category: Surgery Authors: Lauren Miller, Kai Singbartl, Zissis C. Chroneos, Victor Ruiz-Velasco, Charles H. Lang and Anthony Bonavia Tags: Research Source Type: research

Comparison of the source and prognostic utility of cfDNA in trauma and sepsis
Circulating cell-free DNA (cfDNA) may contribute to the pathophysiology of post-injury inflammation and coagulation in trauma. However, the source and mechanism of release of cfDNA in trauma is not well unders... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - May 22, 2019 Category: Surgery Authors: Nicholas L. Jackson Chornenki, Robert Coke, Andrew C. Kwong, Dhruva J. Dwivedi, Michael K. Xu, Ellen McDonald, John C. Marshall, Alison E. Fox-Robichaud, Emmanuel Charbonney and Patricia C. Liaw Tags: Research Source Type: research

Early herpes and TTV DNAemia in septic shock patients: a pilot study
Septic shock patients exhibit an increased incidence of viral reactivation. Precise timing of such reactivation —as an early marker of immune suppression, or as a consequence of the later—is not known precisely... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - May 18, 2019 Category: Surgery Authors: Fran çois Mallet, Magali Perret, Trang Tran, Boris Meunier, Audrey Guichard, Olivier Tabone, Marine Mommert, Karen Brengel-Pesce, Fabienne Venet, Alexandre Pachot, Guillaume Monneret, Frederic Reynier, Christophe Védrine, Philippe Leissner, Virginie Mou Tags: Research Source Type: research