Six methods to determine expiratory time constants in mechanically ventilated patients: a prospective observational physiology study
Expiratory time constant ( τ) objectively assesses the speed of exhalation and can guide adjustments of the respiratory rate and the I:E ratio with the goal of achieving complete exhalation. Multiple methods of ob... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - March 7, 2024 Category: Surgery Authors: Filip Depta, Caitlyn M. Chiofolo, Nicolas W. Chbat, Neil R. Euliano, Michael A. Gentile, Du šan Rybár, Viliam Donič and Marko Zdravkovic Tags: Research Articles Source Type: research

The association between coronary artery calcification and vectorcardiography in mechanically ventilated COVID-19 patients: the Maastricht Intensive Care COVID cohort
Coronary artery calcification (CAC) is associated with poor outcome in critically ill patients. A deterioration in cardiac conduction and loss of myocardial tissue could be an underlying cause. Vectorcardiogra... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - March 7, 2024 Category: Surgery Authors: Eda Aydeniz, Frank van Rosmalen, Jip de Kok, Bibi Martens, Alma M. A. Mingels, Mustafa Emin Canakci, Casper Mihl, Kevin Vernooy, Frits W. Prinzen, Joachim E. Wildberger, Iwan C. C. van der Horst, Bas C. T. van Bussel and Rob G. H. Driessen Tags: Research Articles Source Type: research

Individualised flow-controlled ventilation reduces applied mechanical power and improves ventilation efficiency in a porcine intra-abdominal hypertension model
Aim of this study was to evaluate feasibility and effects of individualised flow-controlled ventilation (FCV), based on compliance guided pressure settings, compared to standard of pressure-controlled ventilat... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - March 7, 2024 Category: Surgery Authors: Julia Abram, Patrick Spraider, Julian Wagner, Gabriel Putzer, Manuela Ranalter, Sarah Rinner, Andrea Katharina Lindner, Bernhard Glodny, Tobias Hell, Tom Barnes, Dietmar Enk and Judith Martini Tags: Research Articles Source Type: research

Glucocorticoid use in acute respiratory failure from pulmonary causes and association with early changes in the systemic host immune response
Glucocorticoids are commonly used in patients with or at-risk for acute respiratory distress syndrome (ARDS), but optimal use remains unclear despite well-conducted clinical trials. We performed a secondary an... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - March 5, 2024 Category: Surgery Authors: Nameer Al-Yousif, Seyed M. Nouraie, Matthew J. Broerman, Yingze Zhang, Tomeka L. Suber, John Evankovich, William G. Bain, Georgios D. Kitsios, Bryan J. McVerry and Faraaz A. Shah Tags: Research Articles Source Type: research

Can we rely on “calibrated” central venous pressure to measure pleural pressure at the bedside?
(Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - March 4, 2024 Category: Surgery Authors: Alessandro Protti and Maurizio Cecconi Tags: Editorial Source Type: research

Esmolol increases the fecal abundance of Lactobacillus in a rat model of sepsis
In this study, we examined the effect of esmolol on the gut microbiome in a rat model of sepsis ... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - March 4, 2024 Category: Surgery Authors: Bo Yao, Fu-hua Wang, Xiao-ning Han, Jun Yang, Ping Xue, Qi Qi, Guang-yao Wei and Jin-yan Xing Tags: Research Articles Source Type: research

Development of personalized non-invasive ventilation masks for critically ill children: a bench study
Obtaining a properly fitting non-invasive ventilation (NIV) mask to treat acute respiratory failure is a major challenge, especially in young children and patients with craniofacial abnormalities. Personalizat... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - March 1, 2024 Category: Surgery Authors: Rosemijne R. W. P. Pigmans, Rozalinde Klein-Blommert, Monica C. van Gestel, Dick G. Markhorst, Peter Hammond, Pim Boomsma, Tim Daams, Julia M. A. de Jong, Paul M. Heeman, Job B. M. van Woensel, Coen D. Dijkman and Reinout A. Bem Tags: Research Articles Source Type: research

Lung- and diaphragm-protective strategies in acute respiratory failure: an in silico trial
The objectives of this study we... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - February 28, 2024 Category: Surgery Authors: Damian Ratano, Binghao Zhang, Jose Dianti, Dimitrios Georgopoulos, Laurent J. Brochard, Timothy C. Y. Chan and Ewan C. Goligher Tags: Research Articles Source Type: research

Association between intravenous fluid administration and endothelial glycocalyx shedding in humans: a systematic review
Several studies have demonstrated associations between greater rate/volume of intravenous (IV) fluid administration and poorer clinical outcomes. One postulated mechanism for harm from exogenous fluids is shed... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - February 26, 2024 Category: Surgery Authors: Sara Sukudom, Lisa Smart and Stephen Macdonald Tags: Reviews Source Type: research

BET-inhibitor DYB-41 reduces pulmonary inflammation and local and systemic cytokine levels in LPS-induced acute respiratory distress syndrome: an experimental rodent study
Acute respiratory distress syndrome (ARDS) is a form of respiratory failure stemming from various underlying conditions that ultimately lead to inflammation and lung fibrosis. Bromodomain and Extra-Terminal mo... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - February 26, 2024 Category: Surgery Authors: Manuela Iten, Camille Gschwend, Alessandro Ostini, David Robert Cameron, Christine Goepfert, David Berger and Matthias Haenggi Tags: Research Articles Source Type: research

Sepsis and obesity: a scoping review of diet-induced obesity murine models
Sepsis, the life-threatening host response to infection, is a major cause of mortality. Obesity increases vulnerability to sepsis; however, some degree of obesity may be protective, called the “obesity paradox... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - February 23, 2024 Category: Surgery Authors: Mikaela Eng, Keshikaa Suthaaharan, Logan Newton, Fatima Sheikh and Alison Fox-Robichaud Tags: Reviews Source Type: research

Response Letter to: Correspondence regarding the article by Murugan et al on Precision net ultrafiltration dosing in continuous kidney replacement therapy: a practical approach
(Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - February 20, 2024 Category: Surgery Authors: Raghavan Murugan, Kianoush Kashani and Paul M. Palevsky Tags: Letter to the Editor Source Type: research

Correspondence regarding the article by Murugan et al. on “Precision net ultrafiltration dosing in continuous kidney replacement therapy: a practical approach”
(Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - February 20, 2024 Category: Surgery Authors: Rinaldo Bellomo Tags: Correspondence Source Type: research

The impact of ECPELLA on haemodynamics and global oxygen delivery: a comprehensive simulation of biventricular failure
ECPELLA, a combination of veno-arterial (VA) extracorporeal membrane oxygenation (ECMO) and Impella, a percutaneous left ventricular (LV) assist device, has emerged as a novel therapeutic option in patients wi... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - February 16, 2024 Category: Surgery Authors: Hiroki Matsushita, Keita Saku, Takuya Nishikawa, Shohei Yokota, Kei Sato, Hidetaka Morita, Yuki Yoshida, Masafumi Fukumitsu, Kazunori Uemura, Toru Kawada and Ken Yamaura Tags: Research Articles Source Type: research

HS-GC –MS analysis of volatile organic compounds after hyperoxia-induced oxidative stress: a validation study
Exhaled volatile organic compounds (VOCs), particularly hydrocarbons from oxidative stress-induced lipid peroxidation, are associated with hyperoxia exposure. However, important heterogeneity amongst identifie... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - February 12, 2024 Category: Surgery Authors: Thijs A. Lilien, Dominic W. Fenn, Paul Brinkman, Laura A. Hagens, Marry R. Smit, Nanon F. L. Heijnen, Job B. M. van Woensel, Lieuwe D. J. Bos and Reinout A. Bem Tags: Research Articles Source Type: research