Reappraisal of intra-abdominal candidiasis: insights from peritoneal fluid analysis
The understanding of high mortality associated with intra-abdominal candidiasis (IAC) remains limited. While Candida is considered a harmless colonizer in the digestive tract, its role as a true pathogen in IAC i... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - September 30, 2023 Category: Surgery Authors: Emmanuel Novy, Mathieu Esposito, Julien Birckener, Adeline Germain, Marie-Reine Losser, Marie-Claire Machouart and Philippe Guerci Tags: Research Articles Source Type: research

Neurofilament light chain on intensive care admission is an independent predictor of mortality in COVID-19: a prospective multicenter study
Neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), and total-tau protein (tau) are novel blood biomarkers of neurological injury, and may be used to predict outcomes in critical COVID-19. (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - September 28, 2023 Category: Surgery Authors: Theodor Sievert, Ingrid Didriksson, Martin Sp ångfors, Gisela Lilja, Kaj Blennow, Henrik Zetterberg, Attila Frigyesi and Hans Friberg Tags: Research Articles Source Type: research

Effects of changes in trunk inclination on ventilatory efficiency in ARDS patients: quasi-experimental study
Trunk inclination from semirecumbent head-upright to supine-flat positioning reduces driving pressure and increases respiratory system compliance in patients with acute respiratory distress syndrome (ARDS). Th... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - September 27, 2023 Category: Surgery Authors: Mart ín H. Benites, David Torres, Fabian Poblete, Francisco Labbe, María C. Bachmann, Tomas E. Regueira, Leonardo Soto, Andrés Ferre, Jorge Dreyse and Jaime Retamal Tags: Research Articles Source Type: research

Tissue oxygenation: how to measure, how much to target
(Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - September 23, 2023 Category: Surgery Authors: Matthias P. Hilty and Christian Jung Tags: Editorial Source Type: research

Fluid restrictive resuscitation with high molecular weight hyaluronan infusion in early peritonitis sepsis
Sepsis is a condition with high morbidity and mortality. Prompt recognition and initiation of treatment is essential. Despite forming an integral part of sepsis management, fluid resuscitation may also lead to... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - September 21, 2023 Category: Surgery Authors: Annelie Barrueta Tenhunen, Jaap van der Heijden, Paul Skorup, Marco Maccarana, Anders Larsson, Anders Larsson, Gaetano Perchiazzi and Jyrki Tenhunen Tags: Research Articles Source Type: research

The effects of resuscitation with different plasma products on endothelial permeability and organ injury in a rat pneumosepsis model
Endothelial injury and permeability are a hallmark of sepsis. Initial resuscitation of septic patients with crystalloids is associated with aggravation of endothelial permeability, which may be related either ... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - September 20, 2023 Category: Surgery Authors: Daan P. van den Brink, Derek J. B. Kleinveld, Annabel Bongers, Ja ël Vos, Joris J. T. H. Roelofs, Nina C. Weber, Jaap D. van Buul and Nicole P. Juffermans Tags: Research Articles Source Type: research

Perioperative advanced haemodynamic monitoring of patients undergoing multivisceral debulking surgery: an observational pilot study
This study aims to characte... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - September 8, 2023 Category: Surgery Authors: Charlotte Middel, Matthias Stetzuhn, Nadine Sander, Bj örn Kalkbrenner, Timo Tigges, Alexandru-Gabriel Pielmus, Claudia Spies, Klaus Pietzner, Michael Klum, Clarissa von Haefen, Oliver Hunsicker, Jalid Sehouli, Frank Konietschke and Aarne Feldheiser Tags: Research Articles Source Type: research

Intra-tidal PaO2 oscillations associated with mechanical ventilation: a pilot study to identify discrete morphologies in a porcine model
Within-breath oscillations in arterial oxygen tension (PaO2) can be detected using fast responding intra-arterial oxygen sensors in animal models. These PaO2 signals, which rise in inspiration and fall in expirat... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - September 6, 2023 Category: Surgery Authors: John N. Cronin, Douglas C. Crockett, Gaetano Perchiazzi, Andrew D. Farmery, Luigi Camporota and Federico Formenti Tags: Research Articles Source Type: research

Role of dexmedetomidine in modifying immune paralysis in patients with septic shock: randomized controlled trial
Immune paralysis can be defined as a hypoinflammatory state associated with the incapacity of the immune system to release proinflammatory mediators despite the clearance of pathogens by antimicrobials. Persis... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - September 4, 2023 Category: Surgery Authors: Mohamed Elayashy, Eman A. Elsayed, Ahmed M. Mukhtar, Sahar Kasem, Sara A. Elmetwally, Sara Habib, Walaa Abdelfattah, Doaa Ghaith and Amr Hussein Tags: Research Articles Source Type: research

Timing and threshold of high sensitive troponin T measurement for the prediction of mortality after cardiac surgery: a retrospective cohort analysis
High sensitive cardiac troponin T (hsTnT) is a widely used biomarker of myocardial injury. Along with other high sensitive troponins, HsTnT can predict mortality in both cardiac and non-cardiac surgery. The ai... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - September 1, 2023 Category: Surgery Authors: Andreas Kok öfer, Crispiana Cozowicz, Bernhard Wernly and Niklas Rodemund Tags: Research Articles Source Type: research

Low ‑to‑moderate hyperoxia in animal models: is there evidence for harm?
(Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - August 28, 2023 Category: Surgery Authors: Thijs A. Lilien and Reinout A. Bem Tags: Correspondence Source Type: research

Statistical properties of cerebral near infrared and intracranial pressure-based cerebrovascular reactivity metrics in moderate and severe neural injury: a machine learning and time-series analysis
Cerebrovascular reactivity has been identified as a key contributor to secondary injury following traumatic brain injury (TBI). Prevalent intracranial pressure (ICP) based indices of cerebrovascular reactivity... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - August 28, 2023 Category: Surgery Authors: Alwyn Gomez, Amanjyot Singh Sainbhi, Kevin Y. Stein, Nuray Vakitbilir, Logan Froese and Frederick A. Zeiler Tags: Research Articles Source Type: research

MesenchymAl stromal cells for Traumatic bRain Injury (MATRIx): a study protocol for a multicenter, double-blind, randomised, placebo-controlled phase II trial
Traumatic brain injury (TBI) is a significant cause of death and disability, with no effective neuroprotective drugs currently available for its treatment. Mesenchymal stromal cell (MSC)-based therapy shows pr... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - August 25, 2023 Category: Surgery Authors: Elisa R. Zanier, Francesca Pischiutta, Eliana Rulli, Alessia Vargiolu, Francesca Elli, Paolo Gritti, Giuseppe Gaipa, Daniela Belotti, Gianpaolo Basso, Tommaso Zoerle, Nino Stocchetti and Giuseppe Citerio Tags: Methodologies Source Type: research

Effect of norepinephrine on the vascular waterfall and tissue perfusion in vasoplegic hypotensive patients: a prospective, observational, applied physiology study in cardiac surgery
Norepinephrine is a commonly used drug for treating vasoplegic acute circulatory failure in ICU. The prediction of norepinephrine macro- and micro-circulatory response is complicated by its uneven receptors ’ d... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - August 21, 2023 Category: Surgery Authors: Stefan Andrei, St éphane Bar, Maxime Nguyen, Bélaid Bouhemad and Pierre-Grégoire Guinot Tags: Research Articles Source Type: research

Distinct host-response signatures in circulatory shock: a narrative review
Circulatory shock is defined syndromically as hypotension associated with tissue hypoperfusion and often subcategorized according to hemodynamic profile (e.g., distributive, cardiogenic, hypovolemic) and etiol... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - August 18, 2023 Category: Surgery Authors: Sabri Soussi, Claudia dos Santos, Jacob C. Jentzer, Alexandre Mebazaa, Etienne Gayat, Janine P öss, Hannah Schaubroeck, Filio Billia, John C. Marshall and Patrick R. Lawler Tags: Reviews Source Type: research