Ultra-low tidal volume ventilation during cardiopulmonary resuscitation shows no mitigating effect on pulmonary end-organ damage compared to standard ventilation: insights from a porcine model
This study aimed to determine whether ultra-low tidal volume ventilation (ULTVV) applied during cardiopulmonary resuscitation (CPR) compared with standard ventilation (intermittent positive pressure ventilatio... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - November 25, 2023 Category: Surgery Authors: Katja Mohnke, Philipp Conzelmann, Miriam Renz, Julian Riedel, Ren é Rissel, Andrea Urmann, Johanna Hain, Bastian Duenges, Alexander Ziebart and Robert Ruemmler Tags: Research Articles Source Type: research

Agreement of pCO2 in venous to arterial blood gas conversion models in undifferentiated emergency patients
Venous blood gas sampling has replaced arterial sampling in many critically ill patients, though interpretation of venous pCO2 still remains a challenge. Lemo ël et al., Farkas and Zeserson et al. have proposed mo... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - November 21, 2023 Category: Surgery Authors: Matthias J örg, Malin Öster, Jens Wretborn and Daniel B. Wilhelms Tags: Research Articles Source Type: research

Protective effect of canagliflozin on post-resuscitation myocardial function in a rat model of cardiac arrest
Currently, most patients with cardiac arrest (CA) show reversible myocardial dysfunction, hemodynamic instability, systemic inflammation and other pathophysiological state in early stage of resuscitation, some... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - November 15, 2023 Category: Surgery Authors: Tianfeng Hua, Yuqian Chu, Minjie Wang, Yijun Zhang, Wei Shi, Qihui Huang, Liangliang Zhang and Min Yang Tags: Research Articles Source Type: research

Body position to optimize mechanics in ARDS: to which degree does the angle matter?
(Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - November 15, 2023 Category: Surgery Authors: Jantine Wisse and Annemijn H. Jonkman Tags: Editorial Source Type: research

Current knowledge gaps in extracorporeal respiratory support
Extracorporeal life support (ECLS) for acute respiratory failure encompasses veno-venous extracorporeal membrane oxygenation (V-V ECMO) and extracorporeal carbon dioxide removal (ECCO2R). V-V ECMO is primarily us... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - November 14, 2023 Category: Surgery Authors: Tommaso Tonetti, Alberto Zanella, David P érez-Torres, Giacomo Grasselli and V. Marco Ranieri Tags: Reviews Source Type: research

Hemodynamic effects of supplemental oxygen versus air in simulated blood loss in healthy volunteers: a randomized, controlled, double-blind, crossover trial
Trauma patients frequently receive supplemental oxygen, but its hemodynamic effects in blood loss are poorly understood. We studied the effects of oxygen on the hemodynamic response and tolerance to simulated ... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - November 10, 2023 Category: Surgery Authors: Sole Lindv åg Lie, Jonny Hisdal, Marius Rehn and Lars Øivind Høiseth Tags: Research Articles Source Type: research

Continuous chest compressions are associated with higher peak inspiratory pressures when compared to 30:2 in an experimental cardiac arrest model
Ventilation during cardiopulmonary resuscitation (CPR) has long been a part of the standard treatment during cardiac arrests. Ventilation is usually given either during continuous chest compressions (CCC) or d... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - November 8, 2023 Category: Surgery Authors: Johan M älberg, Silvia Marchesi, Douglas Spangler, Nermin Hadziosmanovic, David Smekal and Sten Rubertsson Tags: Research Articles Source Type: research

Extracorporeal cardiopulmonary resuscitation in 2023
(Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - October 30, 2023 Category: Surgery Authors: Tobias Wengenmayer, Eike Tigges and Dawid L. Staudacher Tags: Reviews Source Type: research

Diaphragm excursions as proxy for tidal volume during spontaneous breathing in invasively ventilated ICU patients
There is a need to monitor tidal volume in critically ill patients with acute respiratory failure, given its relation with adverse clinical outcome. However, quantification of tidal volume in non-intubated pat... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - October 27, 2023 Category: Surgery Authors: Matthijs L. Janssen, Annemijn H. Jonkman, Myrte Wennen, Evert-Jan Wils, Henrik Endeman and Leo Heunks Tags: Research Articles Source Type: research

Esicm lives 2023
(Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - October 24, 2023 Category: Surgery Tags: Meeting abstracts Source Type: research

Neurovirulent cytokines increase neuronal excitability in a model of coronavirus-induced neuroinflammation
Neurological manifestations of severe coronavirus infections, including SARS-CoV-2, are wide-ranging and may persist following virus clearance. Detailed understanding of the underlying changes in brain functio... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - October 14, 2023 Category: Surgery Authors: Salil R. Rajayer and Stephen M. Smith Tags: Research Articles Source Type: research

Comparison of whole blood cytokine immunoassays for rapid, functional immune phenotyping in critically ill patients with sepsis
Sepsis is characterized by highly heterogeneous immune responses associated with a spectrum of disease severity. Methods that rapidly and sensitively profile these immune responses can potentially personalize ... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - October 13, 2023 Category: Surgery Authors: Anthony S. Bonavia, Abigail Samuelsen, Menglu Liang, Jodi Hanson, Daniel McKeone, Zissis C. Chroneos and E. Scott Halstead Tags: Research Articles Source Type: research

Assessing neutrophil-derived ROS production at the bedside: a potential prognostic tool in severe COVID-19 cases
A prompt and effective immune response is required for clearance of pathogens but exaggerated states of inflammation can cause extensive collateral damage to the host. We have previously used a rapid near-pati... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - October 6, 2023 Category: Surgery Authors: Nazl ıhan Boyacı Dündar, David Sarphie, Kenan Yüce, Ümmügülsüm Gaygısız, O. Tolga Kaskatı, Melda Türkoğlu, Gülbin Aygencel Bıkmaz, Lale Karabıyık, Kayhan Çağlar, Gülendam Bozdayı, Rubina Mian, Paul Moss and Mustafa Necmi İlhan Tags: Research Articles Source Type: research

Introductory editorial for the thematic collection “blood purification in sepsis: from bench to bedside” in intensive care medicine experimental
(Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - September 30, 2023 Category: Surgery Authors: Klaus Stahl and Sascha David Tags: Editorial Source Type: research

Reappraisal of intra-abdominal candidiasis: insights from peritoneal fluid analysis
The understanding of high mortality associated with intra-abdominal candidiasis (IAC) remains limited. While Candida is considered a harmless colonizer in the digestive tract, its role as a true pathogen in IAC i... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - September 30, 2023 Category: Surgery Authors: Emmanuel Novy, Mathieu Esposito, Julien Birckener, Adeline Germain, Marie-Reine Losser, Marie-Claire Machouart and Philippe Guerci Tags: Research Articles Source Type: research