First non-invasive magnetic phrenic nerve and diaphragm stimulation in anaesthetized patients: a proof-of-concept study
Mechanical ventilation has side effects such as ventilator-induced diaphragm dysfunction, resulting in prolonged intensive care unit length of stays. Artificially evoked diaphragmatic muscle contraction may po... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - April 21, 2023 Category: Surgery Authors: Alessandro Panelli, Hermann Georges Bartels, Sven Krause, Michael Andr é Verfuß, Aline Michèle Grimm, Niklas Martin Carbon, Julius J. Grunow, Diego Stutzer, Thomas Niederhauser, Laurent Brochard, Steffen Weber-Carstens and Stefan J. Schaller Tags: Research Articles Source Type: research

Effect of intravenous fluid volume on biomarkers of endothelial glycocalyx shedding and inflammation during initial resuscitation of sepsis
To investigate the effect of IV fluid resuscitation on endothelial glycocalyx (EG) shedding and activation of the vascular endothelium and inflammation. (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - April 17, 2023 Category: Surgery Authors: Stephen Macdonald, Erika Bosio, Gerben Keijzers, Sally Burrows, Moira Hibbs, Helen O ’Donoghue, David Taylor, Ashes Mukherjee, Frances Kinnear, Lisa Smart, Juan-Carlos Ascencio-Lane, Edward Litton, John Fraser, Nathan I. Shapiro, Glenn Arendts and Danie Tags: Research Articles Source Type: research

The effect of gravity-induced preload change on the venous excess ultrasound (VExUS) score and internal jugular vein Doppler in healthy volunteers
The venous excess ultrasound (VExUS) score is a multi-organ Doppler approach to assess venous congestion. Despite growing use of VExUS in research and clinical practice, other veins can be visualized to assess... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - April 14, 2023 Category: Surgery Authors: Jon-Emile S. Kenny, Ross Prager, Philippe Rola, Garett McCulloch, Joseph K. Eibl and Korbin Haycock Tags: Research Articles Source Type: research

ICM experimental is growing, from bench via bedside to big data —and back!
(Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - April 11, 2023 Category: Surgery Authors: Nicole P. Juffermans Tags: Editorial Source Type: research

A randomized porcine study of hemorrhagic shock comparing end-tidal carbon dioxide targeted and proximal systolic blood pressure targeted partial resuscitative endovascular balloon occlusion of the aorta in the mitigation of metabolic injury
The definition of partial resuscitative endovascular balloon occlusion of the aorta (pREBOA) is not yet determined and clinical markers of the degree of occlusion, metabolic effects and end-organ injury that a... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - April 10, 2023 Category: Surgery Authors: Anna Stene Hurts én, David T. McGreevy, Christina Karlsson, Claes G. Frostell, Tal M. Hörer and Kristofer F. Nilsson Tags: Research Articles Source Type: research

Assessment of the inferior vena cava collapsibility from subcostal and trans-hepatic imaging using both M-mode or artificial intelligence: a prospective study on healthy volunteers
Assessment of the inferior vena cava (IVC) respiratory variation may be clinically useful for the estimation of fluid-responsiveness and venous congestion; however, imaging from subcostal (SC, sagittal) region... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - April 3, 2023 Category: Surgery Authors: Filippo Sanfilippo, Luigi La Via, Veronica Dezio, Cristina Santonocito, Paolo Amelio, Giulio Genoese, Marinella Astuto and Alberto Noto Tags: Research Articles Source Type: research

Blood volume in patients likely to be preload responsive: a post hoc analysis of a randomized controlled trial
Preload responsive postoperative patients with signs of inadequate organ perfusion are commonly assumed to be hypovolemic and therefore treated with fluids to increase preload. However, preload is influenced n... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - March 31, 2023 Category: Surgery Authors: Anja Lind én, Svajunas Statkevicius, Johan Bonnevier and Peter Bentzer Tags: Research Articles Source Type: research

Insulin signaling in skeletal muscle during inflammation and/or immobilisation
The decline in the downstream signal transduction pathway of anabolic hormone, insulin, could play a key role in the muscle atrophy and insulin resistance observed in patients with intensive care unit acquired... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - March 27, 2023 Category: Surgery Authors: Julius J. Grunow, Thomas Gan, Heidrun Lewald, J. A. Jeevendra Martyn, Manfred Blobner and Stefan J. Schaller Tags: Research Articles Source Type: research

Impact of intravenous fluid administration on cardiac output and oxygenation during cardiopulmonary resuscitation
The effect of intravenous fluid (IVF) administration during cardiopulmonary resuscitation (CPR) is an unexplored factor that may improve cardiac output (CO) during CPR. The aim of this study was to determine t... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - March 24, 2023 Category: Surgery Authors: Jennifer Lutz, Yosef Levenbrown, Md Jobayer Hossain, Anne Hesek, Kelly E. Massa, James P. Keith and Thomas H. Shaffer Tags: Research Articles Source Type: research

Releasing high positive end-expiratory pressure to a low level generates a pronounced increase in particle flow from the airways
Detecting particle flow from the airways by a non-invasive analyzing technique might serve as an additional tool to monitor mechanical ventilation. In the present study, we used a customized particles in exhal... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - March 17, 2023 Category: Surgery Authors: Ellen Broberg, Leif Pierre, Mohammed Fakhro, Malin Malmsj ö, Sandra Lindstedt and Snejana Hyllén Tags: Research Articles Source Type: research

Bioengineered extracellular vesicles: future of precision medicine for sepsis
Sepsis is a syndromic response to infection and is frequently a final common pathway to death from many infectious diseases worldwide. The complexity and high heterogeneity of sepsis hinder the possibility to ... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - March 10, 2023 Category: Surgery Authors: Aina Areny-Balaguer ó, Anna Solé-Porta, Marta Camprubí-Rimblas, Elena Campaña-Duel, Adrián Ceccato, Anna Roig, Daniel Closa and Antonio Artigas Tags: Reviews Source Type: research

Plasma bioactive adrenomedullin on intensive care unit admission is associated with acute respiratory distress syndrome: an observational study
Bioactive adrenomedullin (bio-ADM) is a vasoactive peptide with a key role in reducing vascular hyperpermeability and improving endothelial stability during infection, but it also has vasodilatory properties. ... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - March 3, 2023 Category: Surgery Authors: Patrik Johnsson, Andrea Fredriksson, Christer Tung, Hans Friberg and Attila Frigyesi Tags: Research Articles Source Type: research

Changes in upper airways microbiota in ventilator-associated pneumonia
The role of upper airways microbiota and its association with ventilator-associated pneumonia (VAP) development in mechanically ventilated (MV) patients is unclear. Taking advantage of data collected in a pros... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - March 2, 2023 Category: Surgery Authors: Laura Alagna, Leonardo Mancabelli, Federico Magni, Liliane Chatenoud, Gabriele Bassi, Silvia Del Bianco, Roberto Fumagalli, Francesca Turroni, Davide Mangioni, Guglielmo M. Migliorino, Christian Milani, Antonio Muscatello, Giovanni Nattino, Edoardo Picett Tags: Research Articles Source Type: research

Elevated free interleukin-18 associated with severity and mortality in prospective cohort study of 206 hospitalised COVID-19 patients
Divergence between deterioration to life-threatening COVID-19 or clinical improvement occurs for most within the first 14 days of symptoms. Life-threatening COVID-19 shares clinical similarities with Macrophag... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - February 24, 2023 Category: Surgery Authors: Syed M. T. Nasser, Anas A. Rana, Rainer Doffinger, Andreas Kafizas, Tauseef A. Khan and Shuaib Nasser Tags: Research Articles Source Type: research

Precision of CT-derived alveolar recruitment assessed by human observers and a machine learning algorithm in moderate and severe ARDS
Assessing measurement error in alveolar recruitment on computed tomography (CT) is of paramount importance to select a reliable threshold identifying patients with high potential for alveolar recruitment and t... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - February 17, 2023 Category: Surgery Authors: Ludmilla Penarrubia, Aude Verstraete, Maciej Orkisz, Eduardo Davila, Loic Boussel, Hodane Yonis, Mehdi Mezidi, Francois Dhelft, William Danjou, Alwin Bazzani, Florian Sigaud, Sam Bayat, Nicolas Terzi, Mehdi Girard, Laurent Bitker, Emmanuel Roux & hellip; Tags: Research Articles Source Type: research