Autonomic nervous system activity and the risk of nosocomial infection in critically ill patients with brain injury
This study investigates whether autonomic nervous system activity is associated with a decreased host immune response in patients followi... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - November 25, 2020 Category: Surgery Authors: Mathijs R. Wirtz, Jiri Moekotte, Kirsten Balvers, Marjolein M. Admiraal, Jean-Francois Pittet, Joe Colombo, Brant M. Wagener, J. Carel Goslings and Nicole Juffermans Tags: Research Source Type: research

Flow-controlled ventilation during EVLP improves oxygenation and preserves alveolar recruitment
Ex vivo lung perfusion (EVLP) is a widespread accepted platform for preservation and evaluation of donor lungs prior to lung transplantation (LTx). Standard lungs are ventilated using volume-controlled ventila... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - November 25, 2020 Category: Surgery Authors: Sofie Ordies, Michaela Orlitova, Tobias Heigl, Annelore Sacreas, Anke Van Herck, Janne Kaes, Berta Saez, Arno Vanstapel, Laurens Ceulemans, Bart M. Vanaudenaerde, Robin Vos, Johny Verschakelen, Geert M. Verleden, Stijn E. Verleden, Dirk E. Van Raemdonck a Tags: Research Source Type: research

SARS-CoV-2 analysis on environmental surfaces collected in an intensive care unit: keeping Ernest Shackleton ’s spirit
Intensive care unit workers are at high risk of acquiring COVID-19 infection, especially when performing invasive techniques and certain procedures that generate aerosols ( (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - November 23, 2020 Category: Surgery Authors: Dolores Escudero, Jos é Antonio Boga, Javier Fernández, Lorena Forcelledo, Salvador Balboa, Rodrigo Albillos, Iván Astola, Emilio García-Prieto, Marta Elena Álvarez-Argüelles, Gabriel Martín, Josu Jiménez and Fernando Vázquez Tags: Research Source Type: research

Does hemofiltration protect the brain after head trauma? An experimental study in rabbits
Traumatic brain injury (TBI) is one of the most frequent and severe neurological diseases. In the last few decades, significant advances have been made in TBI pathophysiology and monitoring, however new treatm... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - November 18, 2020 Category: Surgery Authors: Enrique Martinez-Gonzalez, Dolores Garcia-Olmo, Empar Mayordomo-Aranda, Maria Granada-Picazo, Monica Gomez-Juarez and Jeronimo Moreno-Cuesta Tags: Research Source Type: research

Hydrocortisone decreases lethality and inflammatory cytokine and nitric oxide production in rats challenged with B. anthracis cell wall peptidoglycan
Lethal B. anthracis infection produces high proinflammatory peptidoglycan (PGN) burdens in hosts. We investigated whether the lethality and inflammation anthrax PGN can produce are related. (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - November 18, 2020 Category: Surgery Authors: Yan Li, Xizhong Cui, Joseph Shiloach, Jeffrey Wang, Dante A. Suffredini, Wanying Xu, Wancang Liu, Yvonne Fitz, Junfeng Sun and Peter Q. Eichacker Tags: Research Source Type: research

Fill the critical care discovery pipeline with ICMx!
(Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - November 9, 2020 Category: Surgery Authors: Nicole P. Juffermans and Marcin Osuchowski Tags: Editorial Source Type: research

Regional venous –arterial CO2 to arterial–venous O2 content difference ratio in experimental circulatory shock and hypoxia
Venous –arterial carbon dioxide (CO2) to arterial–venous oxygen (O2) content difference ratio (Cv-aCO2/Ca-vO2) > 1 is supposed to be both sensitive and specific for anaerobic metabolism. What regional hemodynamic ... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - October 29, 2020 Category: Surgery Authors: Thiago Domingos Corr êa, Adriano José Pereira, Jukka Takala and Stephan Mathias Jakob Tags: Research Source Type: research

Veno-venous ECMO as a platform to evaluate lung lavage and surfactant replacement therapy in an animal model of severe ARDS
There are limited therapeutic options directed at the underlying pathological processes in acute respiratory distress syndrome (ARDS). Experimental therapeutic strategies have targeted the protective systems t... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - October 27, 2020 Category: Surgery Authors: Robert Qaqish, Yui Watanabe, Marcos Galasso, Cara Summers, A adil Ali, Mamoru Takahashi, Anajara Gazzalle, Mingyao Liu, Shaf Keshavjee, Marcelo Cypel and Lorenzo Del Sorbo Tags: Research Source Type: research

Neuromuscular blocking agents in acute respiratory distress syndrome: updated systematic review and meta-analysis of randomized trials
Existing clinical practice guidelines support the use of neuromuscular blocking agents (NMBA) in acute respiratory distress syndrome (ARDS); however, a recent large randomized clinical trial (RCT) has question... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - October 23, 2020 Category: Surgery Authors: Nehal Tarazan, Moayad Alshehri, Sameer Sharif, Zainab Al Duhailib, Morten Hylander M øller, Emilie Belley-Cote, Mohammed Alshahrani, John Centofanti, Lauralyn McIntyre, Bandar Baw, Maureen Meade and Waleed Alhazzani Tags: Review Source Type: research

Electrolyte-based calculation of fluid shifts after infusing 0.9% saline in severe hyperglycemia
Early treatment of severe hyperglycemia involves large shifts of body fluids that entail a risk of hemodynamic instability. We studied the feasibility of applying a new electrolyte equation that estimates the ... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - October 13, 2020 Category: Surgery Authors: Robert Svensson, Joachim Zdolsek, Marcus Malm and Robert G. Hahn Tags: Methodology Source Type: research

Right ventricular stroke volume assessed by pulmonary artery pulse contour analysis
Stroke volume measurement should provide estimates of acute treatment responses. The current pulse contour method estimates left ventricle stroke volume. Heart-lung interactions change right ventricular stroke... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - October 7, 2020 Category: Surgery Authors: David Berger, Jan Hobi, Per W. M öller, Matthias Haenggi, Jukka Takala and Stephan M. Jakob Tags: Research Source Type: research

Letter to the Editor: Response to Luke Fletcher and Philip Peyton regarding “Predictive validity of a novel non-invasive estimation of effective shunt fraction in critically ill patients”
(Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - October 1, 2020 Category: Surgery Authors: Emma M. Chang, Andrew Bretherick, Gordon B. Drummond and J. Kenneth Baillie Tags: Letter to the Editor Source Type: research

The endogenous capacity to produce proinflammatory mediators by the ex vivo human perfused lung
The ex vivo human perfused lung model has enabled optimizing donor lungs for transplantation and delineating mechanisms of lung injury. Perfusate and airspace biomarkers are a proxy of the lung response to exp... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - September 21, 2020 Category: Surgery Authors: Aleksandra Leligdowicz, James T. Ross, Nicolas Nesseler and Michael A. Matthay Tags: Research Source Type: research

Diagnostic characteristics of 11 formulae for calculating corrected flow time as measured by a wearable Doppler patch
Change of the corrected flow time (Ftc) is a surrogate for tracking stroke volume (SV) in the intensive care unit. Multiple Ftc equations have been proposed; many have not had their diagnostic characteristics ... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - September 17, 2020 Category: Surgery Authors: Jon- Émile S. Kenny, Igor Barjaktarevic, David C. Mackenzie, Andrew M. Eibl, Matthew Parrotta, Bradley F. Long and Joseph K. Eibl Tags: Research Source Type: research

The relationship between immune status as measured by stimulated ex-vivo tumour necrosis factor alpha levels and the acquisition of nosocomial infections in critically ill mechanically ventilated patients
Immunological dysfunction is common in critically ill patients but its clinical significance and the optimal method to measure it are unknown. The level of tumor necrosis factor alpha (TNF- α) after ex-vivo who... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - September 16, 2020 Category: Surgery Authors: Gabrielle Levin, J. Gordon Boyd, Andrew Day, Miranda Hunt, David M. Maslove, Patrick Norman, Nicole O ’Callaghan, Stephanie Sibley and John Muscedere Tags: Research Source Type: research