COVID-19 and VILI: developing a mobile app for measurement of mechanical power at a glance
The COVID-19 pandemic has increased the need for a bedside tool for lung mechanics assessment and ventilator-induced lung injury (VILI) monitoring. Mechanical power is a unifying concept including all the comp... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - February 9, 2021 Category: Surgery Authors: Angelo Senzi, Marco Bindi, Iacopo Cappellini, Lucia Zamidei and Guglielmo Consales Tags: Letters to the Editor Source Type: research

A novel experimental porcine model to assess the impact of differential pulmonary blood flow on ischemia –reperfusion injury after unilateral lung transplantation
Primary graft dysfunction (PGD) remains a major obstacle after lung transplantation. Ischemia –reperfusion injury is a known contributor to the development of PGD following lung transplantation. We developed a ... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - February 5, 2021 Category: Surgery Authors: Anna Elisabeth Frick, Michaela Orlitov á, Arno Vanstapel, Sofie Ordies, Sandra Claes, Dominique Schols, Tobias Heigl, Janne Kaes, Berta Saez-Gimenez, Robin Vos, Geert M. Verleden, Bart Vanaudenaerde, Stijn E. Verleden, Dirk E. Van Raemdonck and Arne P. N Tags: Research Articles Source Type: research

Lung ultrasound and computed tomography to monitor COVID-19 pneumonia in critically ill patients: a two-center prospective cohort study
Lung ultrasound can adequately monitor disease severity in pneumonia and acute respiratory distress syndrome. We hypothesize lung ultrasound can adequately monitor COVID-19 pneumonia in critically ill patients. (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - January 25, 2021 Category: Surgery Authors: Micah L. A. Heldeweg, Jorge E. Lopez Matta, Mark E. Haaksma, Jasper M. Smit, Carlos V. Elzo Kraemer, Harm-Jan de Grooth, Evert de Jonge, Lilian J. Meijboom, Leo M. A. Heunks, David J. van Westerloo and Pieter R. Tuinman Tags: Research Articles Source Type: research

Serum cytokines profile of critically ill COVID-19 patients with cardiac dysfunction
(Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - January 18, 2021 Category: Surgery Authors: Fran çois Bagate, Nicolas Maziers, Sophie Hue, Paul Masi, Armand Mekontso Dessap and Nicolas de Prost Tags: Letters to the Editor Source Type: research

Bedside monitoring of lung volume available for gas exchange
Bedside measurement of lung volume may provide guidance in the personalised setting of respiratory support, especially in patients with the acute respiratory distress syndrome at risk of ventilator-induced lun... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - January 11, 2021 Category: Surgery Authors: Minh C. Tran, Douglas C. Crockett, John N. Cronin, Jo ão Batista Borges, Göran Hedenstierna, Anders Larsson, Andrew D. Farmery and Federico Formenti Tags: Research Articles Source Type: research

In vitro testing of cyanoacrylate tissue adhesives and sutures for extracorporeal membrane oxygenation cannula securement
Extracorporeal membrane oxygenation (ECMO), an invasive mechanical therapy, provides cardio-respiratory support to critically ill patients when maximal conventional support has failed. ECMO is delivered via la... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - January 4, 2021 Category: Surgery Authors: India Pearse, Amanda Corley, Nicole Bartnikowski and John F. Fraser Tags: Research Articles Source Type: research

Ischaemic stroke-induced distal organ damage: pathophysiology and new therapeutic strategies
Acute ischaemic stroke is associated with a high risk of non-neurological complications, which include respiratory failure, cardiovascular dysfunction, kidney and liver injury, and altered immune and endocrine... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - December 18, 2020 Category: Surgery Authors: Chiara Robba, Denise Battaglini, Cynthia S. Samary, Pedro L. Silva, Lorenzo Ball, Patricia R. M. Rocco and Paolo Pelosi Tags: Review Source Type: research

H2S in acute lung injury: a therapeutic dead end(?)
This review addresses the plausibility of hydrogen sulfide (H2S) therapy for acute lung injury (ALI) and circulatory shock, by contrasting the promising preclinical results to the present clinical reality. The re... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - December 18, 2020 Category: Surgery Authors: Tamara Merz, Nicole Denoix, Martin Wepler, Holger G äßler, David A. C. Messerer, Clair Hartmann, Thomas Datzmann, Peter Radermacher and Oscar McCook Tags: Review Source Type: research

Prognostic classification based on P/F and PEEP in invasively ventilated ICU patients with hypoxemia —insights from the MARS study
Outcome prediction in patients with acute respiratory distress syndrome (ARDS) greatly improves when patients are reclassified based on predefined arterial oxygen partial pressure to fractional inspired oxygen... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - December 18, 2020 Category: Surgery Authors: Fabienne D. Simonis, Laura R. A. Schouten, Olaf L. Cremer, David S. Y. Ong, Gabriele Amoruso, Gilda Cinella, Marcus J. Schultz and Lieuwe D. Bos Tags: Research Source Type: research

Effect of routine vs on-demand nebulization of acetylcysteine with salbutamol on accumulation of airway secretions in endotracheal tubes: substudy of a randomized clinical trial
Accumulated airway secretions in the endotracheal tube increase work of breathing and may favor airway colonization eventually leading to pneumonia. The aim of this preplanned substudy of the ‘Preventive Nebul... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - December 18, 2020 Category: Surgery Authors: Sophia van der Hoeven, Lorenzo Ball, Federico Constantino, David M. van Meenen, Paolo Pelosi, Ludo F. Beenen, Marcus J. Schultz and Frederique Paulus Tags: Research Source Type: research

The effects of tidal volume size and driving pressure levels on pulmonary complement activation: an observational study in critically ill patients
Mechanical ventilation can induce or even worsen lung injury, at least in part via overdistension caused by too large volumes or too high pressures. The complement system has been suggested to play a causative... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - December 18, 2020 Category: Surgery Authors: Friso M. de Beer, Luuk Wieske, Gerard van Mierlo, Diana Wouters, Sacha Zeerleder, Lieuwe D. Bos, Nicole P. Juffermans, Marcus J. Schultz, Tom van der Poll, Wim K. Lagrand and Janneke Horn Tags: Research Source Type: research

Changes in left ventricular electromechanical relations during targeted hypothermia
Targeted hypothermia, as used after cardiac arrest, increases electrical and mechanical systolic duration. Differences in duration of electrical and mechanical systole are correlated to ventricular arrhythmias... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - December 14, 2020 Category: Surgery Authors: Kristin Wisl øff-Aase, Viesturs Kerans, Kristina Haugaa, Per Steinar Halvorsen, Helge Skulstad and Andreas Espinoza Tags: Research Articles Source Type: research

Esicm lives 2020
(Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - December 14, 2020 Category: Surgery Tags: Meeting abstracts Source Type: research

Transcriptional profiling of leukocytes in critically ill COVID19 patients: implications for interferon response and coagulation
COVID19 is caused by the SARS-CoV-2 virus and has been associated with severe inflammation leading to organ dysfunction and mortality. Our aim was to profile the transcriptome in leukocytes from critically ill... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - December 11, 2020 Category: Surgery Authors: Sean E. Gill, Claudia C. dos Santos, David B. O ’Gorman, David E. Carter, Eric K. Patterson, Marat Slessarev, Claudio Martin, Mark Daley, Michael R. Miller, Gediminas Cepinskas and Douglas D. Fraser Tags: Research Articles Source Type: research

Endotoxemia and circulating bacteriome in severe COVID-19 patients
When severe, COVID-19 shares many clinical features with bacterial sepsis. Yet, secondary bacterial infection is uncommon. However, as epithelium is injured and barrier function is lost, bacterial products ent... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - December 7, 2020 Category: Surgery Authors: Phatadon Sirivongrangson, Win Kulvichit, Sunchai Payungporn, Trairak Pisitkun, Ariya Chindamporn, Sadudee Peerapornratana, Prapaporn Pisitkun, Suwalak Chitcharoen, Vorthon Sawaswong, Navaporn Worasilchai, Sarinya Kampunya, Opass Putcharoen, Thammasak Thaw Tags: Research Articles Source Type: research