Influence of noise manipulation on retention in a simulated ICU ward round: an experimental pilot study
Noise exposure leads to a reduction in cognitive abilities in diverse settings, however, only limited data exist examining the effects of environmental ICU noise on the cognitive performance of ICU professiona... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - January 28, 2022 Category: Surgery Authors: Katja Erne, Samuel E. J. Knobel, Aileen C. Naef, Stephan M. Gerber, Tim Fischer, Fred W. Mast, Joerg C. Schefold, Bjoern Zante, Tobias Nef and Marie-Madlen Jeitziner Tags: Research Articles Source Type: research

Structural equation modelling the relationship between anti-fungal prophylaxis and Pseudomonas bacteremia in ICU patients
Animal models implicate candida colonization facilitating invasive bacterial infections. The clinical relevance of this microbial interaction remains undefined and difficult to study directly. Observations fro... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - January 21, 2022 Category: Surgery Authors: James C. Hurley Tags: Research Articles Source Type: research

The effect of shock duration on trauma-induced coagulopathy in a murine model
In this study, the aim was to determine the e... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - January 7, 2022 Category: Surgery Authors: Pieter H. Sloos, M. Adrie W. Maas, Markus W. Hollmann, Nicole P. Juffermans and Derek J. B. Kleinveld Tags: Research Articles Source Type: research

Mesenchymal stem/stromal cell-based therapies for severe viral pneumonia: therapeutic potential and challenges
Severe viral pneumonia is a significant cause of morbidity and mortality globally, whether due to outbreaks of endemic viruses, periodic viral epidemics, or the rarer but devastating global viral pandemics. Wh... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - December 31, 2021 Category: Surgery Authors: C. H. Masterson, A. Ceccato, A. Artigas, C. dos Santos, P. R. Rocco, S. Rolandsson Enes, D. J. Weiss, D. McAuley, M. A. Matthay, K. English, G. F. Curley and J. G. Laffey Tags: Reviews Source Type: research

Towards an ecological definition of sepsis: a viewpoint
In critically ill patients with sepsis, there is a grave lack of effective treatment options to address the illness-defining inappropriate host response. Currently, treatment is limited to source control and s... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - December 29, 2021 Category: Surgery Authors: Michael Bauer, Manu Shankar-Hari, Daniel O. Thomas-R üddel and Reinhard Wetzker Tags: Reviews Source Type: research

A clinically relevant sheep model of orthotopic heart transplantation 24 h after donor brainstem death
Heart transplantation (HTx) from brainstem dead (BSD) donors is the gold-standard therapy for severe/end-stage cardiac disease, but is limited by a global donor heart shortage. Consequently, innovative solutio... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - December 24, 2021 Category: Surgery Authors: Louise E. See Hoe, Karin Wildi, Nchafatso G. Obonyo, Nicole Bartnikowski, Charles McDonald, Kei Sato, Silver Heinsar, Sanne Engkilde-Pedersen, Sara Diab, Margaret R. Passmore, Matthew A. Wells, Ai-Ching Boon, Arlanna Esguerra, David G. Platts, Lynnette Ja Tags: Methodologies Source Type: research

Hysteretic device characteristics indicate cardiac contractile state for guiding mechanical circulatory support device use
Acute heart failure and cardiogenic shock remain highly morbid conditions despite prompt medical therapy in critical care settings. Mechanical circulatory support (MCS) is a promising therapy for these patient... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - December 20, 2021 Category: Surgery Authors: Brian Y. Chang, Zhengyang Zhang, Kimberly Feng, Noam Josephy, Steven P. Keller and Elazer R. Edelman Tags: Research Articles Source Type: research

Do alterations in pulmonary vascular tone result in changes in central blood volumes? An experimental study
The effects of selective pulmonary vascular tone alterations on cardiac preload have not been previously examined. Therefore, we evaluated whether changing pulmonary vascular tone either by hypoxia or the inha... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - December 17, 2021 Category: Surgery Authors: Jaap Jan Vos, J. K. G ötz Wietasch, Andreas Hoeft and Thomas W. L. Scheeren Tags: Research Articles Source Type: research

Molecular mechanisms of postintensive care syndrome
(Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - December 3, 2021 Category: Surgery Authors: Paula Mart ín-Vicente, Cecilia López-Martínez, Inés Lopez-Alonso, Josefina López-Aguilar, Guillermo M. Albaiceta and Laura Amado-Rodríguez Tags: Reviews Source Type: research

Effects of therapeutic plasma exchange on the endothelial glycocalyx in septic shock
Disruption of the endothelial glycocalyx (eGC) is observed in septic patients and its injury is associated with multiple-organ failure and inferior outcomes. Besides this biomarker function, increased blood co... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - November 24, 2021 Category: Surgery Authors: Klaus Stahl, Uta Carola Hillebrand, Yulia Kiyan, Benjamin Seeliger, Julius J. Schmidt, Heiko Schenk, Thorben Pape, Bernhard M. W. Schmidt, Tobias Welte, Marius M. Hoeper, Agnes Sauer, Malgorzata Wygrecka, Christian Bode, Heiner Wedemeyer, Hermann Haller a Tags: Research Articles Source Type: research

Neutrophil gelatinase-associated lipocalin does not originate from the kidney during reperfusion in clinical renal transplantation
Acute Kidney Injury (AKI) is a common clinical complication. Plasma/serum neutrophil gelatinase-associated lipocalin (NGAL) has been proposed as a rapid marker of AKI. However, NGAL is not kidney-specific. It ... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - November 22, 2021 Category: Surgery Authors: Arie Passov, Minna Ilmakunnas, Marjut Pihlajoki, Kethe Hermunen, Marko Lempinen, Ilkka Helanter ä, Villemikko Kailari, Markku Heikinheimo, Sture Andersson and Eero Pesonen Tags: Research Articles Source Type: research

Intracycle power and ventilation mode as potential contributors to ventilator-induced lung injury
High rates of inflation energy delivery coupled with transpulmonary tidal pressures of sufficient magnitude may augment the risk of damage to vulnerable, stress-focused units within a mechanically heterogeneou... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - November 1, 2021 Category: Surgery Authors: John J. Marini, Philip S. Crooke, Pierre Tawfik, Robert L. Chatburn, David J. Dries and Luciano Gattinoni Tags: Research Articles Source Type: research

Data automated bag breathing unit for COVID-19 ventilator shortages
The COVID-19 pandemic has caused a global mechanical ventilator shortage for treatment of severe acute respiratory failure. Development of novel breathing devices has been proposed as a low cost, rapid solutio... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - October 18, 2021 Category: Surgery Authors: Aleksandra B. Gruslova, Nitesh Katta, Andrew G. Cabe, Scott F. Jenney, Jonathan W. Valvano, Tim B. Phillips, Austin B. McElroy, Robert K. LaSalle, Aydin Zahedivash, Van N. Truskett, Nishi Viswanathan, Marc D. Feldman, Richard B. Wettstein, Thomas E. Milne Tags: Research Articles Source Type: research

ESICM LIVES 2021: Part 2
(Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - October 11, 2021 Category: Surgery Tags: Meeting abstracts Source Type: research

Plasma hyaluronan, hyaluronidase activity and endogenous hyaluronidase inhibition in sepsis: an experimental and clinical cohort study
In this study we evaluate the roles of plasma hyalu... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - October 11, 2021 Category: Surgery Authors: Jaap van der Heijden, Constantinos Kolliopoulos, Paul Skorup, Marko Sallisalmi, Paraskevi Heldin, Michael Hultstr öm and Jyrki Tenhunen Tags: Research Articles Source Type: research