Correction: Circular RNAs to predict clinical outcome after cardiac arrest
(Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - November 9, 2022 Category: Surgery Authors: Francesca M. Stefanizzi, Lu Zhang, Antonio Salgado-Somoza, Josef Dankiewicz, Pascal Stammet, Christian Hassager, Matthew P. Wise, Hans Friberg, Tobias Cronberg, Alexander Hundt, Jesper Kjaergaard, Niklas Nielsen and Yvan Devaux Tags: Correction Source Type: research

Effect of noradrenaline on propofol-induced mitochondrial dysfunction in human skeletal muscle cells
Mitochondrial dysfunction is a hallmark of both critical illness and propofol infusion syndrome and its severity seems to be proportional to the doses of noradrenaline, which patients are receiving. We compreh... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - November 8, 2022 Category: Surgery Authors: Ad éla Krajčová, Christine Skagen, Valér Džupa, Tomáš Urban, Arild C. Rustan, Kateřina Jiroutková, Bohumil Bakalář, G. Hege Thoresen and František Duška Tags: Research Articles Source Type: research

Pathophysiology of fluid administration in critically ill patients
Fluid administration is a cornerstone of treatment of critically ill patients. The aim of this review is to reappraise the pathophysiology of fluid therapy, considering the mechanisms related to the interplay ... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - November 4, 2022 Category: Surgery Authors: Antonio Messina, Jan Bakker, Michelle Chew, Daniel De Backer, Olfa Hamzaoui, Glenn Hernandez, Sheila Nainan Myatra, Xavier Monnet, Marlies Ostermann, Michael Pinsky, Jean-Louis Teboul and Maurizio Cecconi Tags: Reviews Source Type: research

Dysregulated expression of amino-acid and glucose transporters on circulating plasma cells in septic shock patients: a preliminary study
(Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - October 31, 2022 Category: Surgery Authors: Margot Lepage, Morgane Gossez, Anne-Claire Lukaszewicz, Guillaume Monneret and Fabienne Venet Tags: Letters to the Editor Source Type: research

Circular RNAs to predict clinical outcome after cardiac arrest
Cardiac arrest (CA) represents the third leading cause of death worldwide. Among patients resuscitated and admitted to hospital, death and severe neurological sequelae are frequent but difficult to predict. Bl... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - October 28, 2022 Category: Surgery Authors: Francesca M. Stefanizzi, Lu Zhang, Antonio Salgado-Somoza, Josef Dankiewicz, Pascal Stammet, Christian Hassager, Matthew P. Wise, Hans Friberg, Tobias Cronberg, Alexander Hundt, Jesper Kjaergaard, Niklas Nielsen and Yvan Devaux Tags: Research Articles Source Type: research

Cerebral monitoring in a pig model of cardiac arrest with 48 h of intensive care
Neurological injury is the primary cause of death after out-of-hospital cardiac arrest. There is a lack of studies investigating cerebral injury beyond the immediate post-resuscitation phase in a controlled ca... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - October 26, 2022 Category: Surgery Authors: Lauge Vammen, Cecilie Munch Johannsen, Andreas Magnussen, Amalie Povlsen, S øren Riis Petersen, Arezo Azizi, Michael Pedersen, Anders Rosendal Korshøj, Steffen Ringgaard, Bo Løfgren, Lars W. Andersen and Asger Granfeldt Tags: Research Articles Source Type: research

T cell dysregulation in inflammatory diseases in ICU
Severe inflammatory diseases, including sepsis, are characterized by an impaired host adaptive and innate immunity which results in immunosuppression, responsible for secondary infections and increased morbidi... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - October 24, 2022 Category: Surgery Authors: Marta Luperto and Lara Zafrani Tags: Reviews Source Type: research

ESICM LIVES 2022: part 1
(Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - October 19, 2022 Category: Surgery Tags: Meeting abstracts Source Type: research

ESICM LIVES 2022: part 2
(Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - October 19, 2022 Category: Surgery Tags: Meeting abstracts Source Type: research

Development and validation of an early warning model for hospitalized COVID-19 patients: a multi-center retrospective cohort study
Timely identification of deteriorating COVID-19 patients is needed to guide changes in clinical management and admission to intensive care units (ICUs). There is significant concern that widely used Early warn... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - September 19, 2022 Category: Surgery Authors: Jim M. Smit, Jesse H. Krijthe, Andrei N. Tintu, Henrik Endeman, Jeroen Ludikhuize, Michel E. van Genderen, Shermarke Hassan, Rachida El Moussaoui, Peter E. Westerweel, Robbert J. Goekoop, Geeke Waverijn, Tim Verheijen, Jan G. den Hollander, Mark G. J. de Tags: Research Articles Source Type: research

Hemodynamic management of acute brain injury caused by cerebrovascular diseases: a survey of the European Society of Intensive Care Medicine
The optimal hemodynamic targets and management of patients with acute brain injury are not completely elucidated, but recent evidence points to important impact on clinical outcomes. We performed an internatio... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - September 12, 2022 Category: Surgery Authors: Antonio Messina, Federico Villa, Giulia Lionetti, Laura Galarza, Geert Meyfroidt, Mathieu van der Jagt, Xavier Monnet, Paolo Pelosi, Maurizio Cecconi and Chiara Robba Tags: Research Articles Source Type: research

Comparison of two porcine acute lung injury models: a post-hoc analysis
Acute respiratory distress syndrome (ARDS) is a common disease in intensive care medicine. Despite intensive research, mortality rates are high, not even in COVID-19 ARDS. Thereby, pigs offer some advantages t... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - September 5, 2022 Category: Surgery Authors: Ren é Rissel, Miriam Renz, Katja Mohnke, Julian Riedel, Katharina Ritter, Alexander Ziebart, Robert Ruemmler, Erik K. Hartmann and Jens Kamuf Tags: Research Articles Source Type: research

Plasma volume expansion reveals hidden metabolic acidosis in patients with diabetic ketoacidosis
Hyperchloremic metabolic acidosis that develops during the treatment of diabetic ketoacidosis is usually attributed to the chloride content of resuscitation fluids. We explored an alternative explanation, name... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - August 29, 2022 Category: Surgery Authors: Robert Svensson, Robert G. Hahn, Joachim H. Zdolsek and Hans Bahlmann Tags: Research Articles Source Type: research

Physiologic responses to exercise in survivors of critical illness: an exploratory pilot study
ICU survivors suffer from impaired physical function and reduced exercise capacity, yet the underlying mechanisms are poorly understood. The goal of this exploratory pilot study was to investigate potential me... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - August 26, 2022 Category: Surgery Authors: Matthew F. Mart, E. Wesley Ely, James J. Tolle, Mayur B. Patel and Nathan E. Brummel Tags: Research Articles Source Type: research

Fingolimod does not prevent syndecan-4 shedding from the endothelial glycocalyx in a cultured human umbilical vein endothelial cell model of vascular injury
Shedding of the endothelial glycocalyx (EG) is associated with poor outcomes in a range of conditions including sepsis. Fresh frozen plasma (FFP) restores the damaged EG to baseline thickness, however the mech... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - August 18, 2022 Category: Surgery Authors: Elissa M. Milford, Lara Meital, Anna Kuballa, Michael C. Reade and Fraser D. Russell Tags: Research Articles Source Type: research