Fingolimod does not prevent syndecan-4 shedding from the endothelial glycocalyx in a cultured human umbilical vein endothelial cell model of vascular injury

Shedding of the endothelial glycocalyx (EG) is associated with poor outcomes in a range of conditions including sepsis. Fresh frozen plasma (FFP) restores the damaged EG to baseline thickness, however the mech...

Source: Intensive Care Medicine Experimental - August 18, 2022 Category: Surgery Authors: Elissa M. Milford, Lara Meital, Anna Kuballa, Michael C. Reade and Fraser D. Russell Tags: Research Articles Source Type: research