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The conundrum of using hyperoxia in COVID-19 treatment strategies: may intermittent therapeutic hyperoxia play a helpful role in the expression of the surface receptors ACE2 and Furin in lung tissue via triggering of HIF-1 α?
(Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - September 15, 2020 Category: Surgery Authors: Andreas Koch, Wataru K ähler, Sebastian Klapa, Bente Grams and Pieter- Jan A. M. van Ooij Tags: Hypothesis Source Type: research

A mock circulation loop to test extracorporeal CO2 elimination setups
Extracorporeal carbon dioxide removal (ECCO2R) is a promising yet limited researched therapy for hypercapnic respiratory failure in acute respiratory distress syndrome and exacerbated chronic obstructive pulmonar... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - September 11, 2020 Category: Surgery Authors: Leonie S. Schw ärzel, Anna M. Jungmann, Nicole Schmoll, Frederik Seiler, Ralf M. Muellenbach, Joachim Schenk, Quoc Thai Dinh, Robert Bals, Philipp M. Lepper and Albert J. Omlor Tags: Research Source Type: research

Repeated measures of Heparin-binding protein (HBP) and procalcitonin during septic shock: biomarker kinetics and association with cardiovascular organ dysfunction
Heparin-binding protein (HBP) is a neutrophil-derived pro-inflammatory protein, an inducer of endothelial dysfunction and vascular permeability and a promising prognostic biomarker in sepsis. This exploratory ... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - September 10, 2020 Category: Surgery Authors: Jonas Tverring, Niklas Nielsen, Josef Dankiewicz, Adam Linder, Fredrik Kahn and Per Åkesson Tags: Research Source Type: research

Intravenous calcium as a pressor in a swine model of hypoxic pseudo-pulseless electrical mechanical activity —a preliminary report
Pseudo-pulseless electrical activity (pseudo-PEA) is a lifeless form of profound cardiac shock characterized by measurable cardiac mechanical activity without clinically detectable pulses. Pseudo-PEA may const... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - September 4, 2020 Category: Surgery Authors: Alexander L. Lindqwister, Joshua W. Lampe, Jeffrey R. Gould, Christopher L. Kaufman, Karen L. Moodie and Norman A. Paradis Tags: Research Source Type: research

Vendor effects on murine gut microbiota and its influence on lipopolysaccharide-induced lung inflammation and Gram-negative pneumonia
The microbiome has emerged as an important player in the pathophysiology of a whole spectrum of diseases that affect the critically ill. We hypothesized that differences in microbiota composition across vendor... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - August 25, 2020 Category: Surgery Authors: Nora S. Wolff, Max C. Jacobs, Bastiaan W. Haak, Joris J. T. H. Roelofs, Alex F. de Vos, Floor Hugenholtz and W. Joost Wiersinga Tags: Research Source Type: research