Soluble TREM-1 plasma concentration predicts poor outcome in COVID-19 patients
The immuno-receptor Triggering Expressed on Myeloid cells-1 (TREM-1) is activated during bacterial infectious diseases, where it amplifies the inflammatory response. Small studies suggest that TREM-1 could be ... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - August 14, 2023 Category: Surgery Authors: S ébastien Gibot, Thomas Lafon, Laurent Jacquin, Benjamin Lefevre, Antoine Kimmoun, Anne Guillaumot, Marie-Reine Losser, Marion Douplat, Laurent Argaud, Guillaume De Ciancio, Lucie Jolly, Nina Touly, Marc Derive, Catherine Malaplate, Amandine Luc, Cédri Tags: Research Articles Source Type: research

Perioperative lung function following flow controlled ventilation for robot-assisted prostatectomies in steep trendelenburg position: an observational study
Steep Trendelenburg position combined with capnoperitoneum can lead to pulmonary complications and prolonged affection of postoperative lung function. Changes in pulmonary function occur independent of differe... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - August 11, 2023 Category: Surgery Authors: Mustafa Syrafe, Wiebke K öhne, Andre Börgers, Heinrich Löwen, Susanne Krege and Harald Groeben Tags: Research Articles Source Type: research

Clinical phenotypes and outcomes associated with SARS-CoV-2 Omicron variants BA.2, BA.5 and BQ.1.1 in critically ill patients with COVID-19: a prospective, multicenter cohort study
Despite current broad natural and vaccine-induced protection, a substantial number of patients infected with emerging SARS-CoV-2 variants (e.g., BF.7 and BQ.1.1) still experience severe COVID-19. Real-life stu... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - August 7, 2023 Category: Surgery Authors: Nicolas de Prost, Etienne Audureau, S ébastien Préau, Raphaël Favory, Aurélie Guigon, Pierre Bay, Nicholas Heming, Elyanne Gault, Tài Pham, Amal Chaghouri, Guillaume Voiriot, Laurence Morand-Joubert, Sébastien Jochmans, Aurélia Pitsch, Sylvie Meire Tags: Research Articles Source Type: research

The impact of sedative and vasopressor agents on cerebrovascular reactivity in severe traumatic brain injury
The aim of this study is to evaluate the impact of commonly administered sedatives (Propofol, Alfentanil, Fentanyl, and Midazolam) and vasopressor (Dobutamine, Ephedrine, Noradrenaline and Vasopressin) agents ... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - August 5, 2023 Category: Surgery Authors: Logan Froese, Emma Hammarlund, Cecilia A. I. Åkerlund, Jonathan Tjerkaski, Erik Hong, Caroline Lindblad, David W. Nelson, Eric P. Thelin and Frederick A. Zeiler Tags: Research Articles Source Type: research

Multiorgan recovery in a cadaver body using mild hypothermic ECMO treatment in a murine model
Transplant candidates on the waiting list are increasingly challenged by the lack of organs. Most of the organs can only be kept viable within very limited timeframes (e.g., mere 4 –6 h for heart and lungs expo... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - August 4, 2023 Category: Surgery Authors: Nodir Madrahimov, Vitalii Mutsenko, Ruslan Natanov, Dejan Radakovi ć, André Klapproth, Mohamed Hassan, Mathias Rosenfeldt, Florian Kleefeldt, Ivan Aleksic, Süleyman Ergün, Christoph Otto, Rainer G. Leyh and Constanze Bening Tags: Research Articles Source Type: research

Splanchnic sympathetic nerve denervation improves bacterial clearance and clinical recovery in established ovine Gram-negative bacteremia
The autonomic nervous system can modulate the innate immune responses to bacterial infections via the splanchnic sympathetic nerves. Here, we aimed to determine the effects of bilateral splanchnic sympathetic ... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - August 3, 2023 Category: Surgery Authors: Rachel M. Peiris, Clive N. May, Lindsea C. Booth, Robin M. McAllen, Michael J. McKinley, Sally Hood, Davide Martelli, Rinaldo Bellomo and Yugeesh R. Lankadeva Tags: Research Articles Source Type: research

Weaning assessment of veno-arteriovenous (V-AV) extracorporeal membrane oxygenation (ECMO)
Currently, there is a lack of methods for simultaneous assessment of readiness for decannulation of the veno-venous (V-V) and veno-arterial (V-A) components during veno-arteriovenous (V-AV) extracorporal membr... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - August 1, 2023 Category: Surgery Authors: Johannes Heymer, Anna Hein, Matthias Ott, Tobias Schilling and Daniel R äpple Tags: Hypothesis Source Type: research

Fluid management strategies and their interaction with mechanical ventilation: from experimental studies to clinical practice
Patients on mechanical ventilation may receive intravenous fluids via restrictive or liberal fluid management. A clear and objective differentiation between restrictive and liberal fluid management strategies ... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - July 21, 2023 Category: Surgery Authors: Eduardo Butturini de Carvalho, Denise Battaglini, Chiara Robba, Manu L. N. G. Malbrain, Paolo Pelosi, Patricia Rieken Macedo Rocco and Pedro Leme Silva Tags: Reviews Source Type: research

Development and characterization of a fecal-induced peritonitis model of murine sepsis: results from a multi-laboratory study and iterative modification of experimental conditions
Preclinical sepsis models have been criticized for their inability to recapitulate human sepsis and suffer from methodological shortcomings that limit external validity and reproducibility. The National Precli... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - July 17, 2023 Category: Surgery Authors: Neha Sharma, Damian Chwastek, Dhruva J. Dwivedi, Jared Schlechte, Ian-Ling Yu, Braedon McDonald, Jaskirat Arora, Erblin Cani, Mikaela Eng, Doreen Engelberts, Eva Kuhar, Sarah K. Medeiros, Stephane L. Bourque, Gediminas Cepinskas, Sean E. Gill, Forough Jah Tags: Research Articles Source Type: research

Serum proteome profiles in patients treated with targeted temperature management after out-of-hospital cardiac arrest
Definition of temporal serum proteome profiles after out-of-hospital cardiac arrest may identify biological processes associated with severe hypoxia –ischaemia and reperfusion. It may further explore interventi... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - July 17, 2023 Category: Surgery Authors: Gabriele Lileikyte, Anahita Bakochi, Ashfaq Ali, Marion Moseby-Knappe, Tobias Cronberg, Hans Friberg, Gisela Lilja, Helena Levin, Filip Årman, Sven Kjellström, Josef Dankiewicz, Christian Hassager, Johan Malmström and Niklas Nielsen Tags: Research Articles Source Type: research

A closed-loop ventilation mode that targets the lowest work and force of breathing reduces the transpulmonary driving pressure in patients with moderate-to-severe ARDS
The driving pressure ( ΔP) has an independent association with outcome in patients with acute respiratory distress syndrome (ARDS). INTELLiVENT-Adaptive Support Ventilation (ASV) is a closed-loop mode of ventilati... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - July 14, 2023 Category: Surgery Authors: Laura A. Buiteman-Kruizinga, David M. P. van Meenen, Lieuwe D. J. Bos, Pim L. J. van der Heiden, Frederique Paulus and Marcus J. Schultz Tags: Research Articles Source Type: research

Inferior vena cava distensibility from subcostal and trans-hepatic imaging using both M-mode or artificial intelligence: a prospective study on mechanically ventilated patients
Variation of inferior vena cava (IVC) is used to predict fluid-responsiveness, but the IVC visualization with standard sagittal approach (SC, subcostal) cannot be always achieved. In such cases, coronal trans-... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - July 10, 2023 Category: Surgery Authors: Filippo Sanfilippo, Luigi La Via, Veronica Dezio, Paolo Amelio, Giulio Genoese, Federico Franchi, Antonio Messina, Chiara Robba and Alberto Noto Tags: Research Articles Source Type: research

The metabolic cost of inspiratory muscle training in mechanically ventilated patients in critical care
Diaphragmatic dysfunction is well documented in patients receiving mechanical ventilation. Inspiratory muscle training (IMT) has been used to facilitate weaning by strengthening the inspiratory muscles, yet th... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - July 7, 2023 Category: Surgery Authors: Timothy O. Jenkins, Vicky MacBean, Mathias Krogh Poulsen, Dan Stieper Karbing, Stephen Edward Rees, Brijesh V. Patel and Michael I. Polkey Tags: Research Articles Source Type: research

Quadriceps handheld dynamometry during the post-ICU trajectory: using strictly the same body position is mandatory for repeated measures
The level of quadriceps strength (QS) generated in the supine or seated position is not similar. For QS follow-up from intensive care unit (ICU) stay to recovery, getting comparable measures is essential. This... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - July 3, 2023 Category: Surgery Authors: Anne-Fran çoise Rousseau, Nadia Dardenne, Isabelle Kellens, Stephen Bornheim, Benoit Misset and Jean-Louis Croisier Tags: Research Articles Source Type: research

Efficacy of endotracheal tube clamping to prevent positive airways pressure loss and pressure behavior after reconnection: a bench study
Endotracheal tube (ETT) clamping before disconnecting the patient from the mechanical ventilator is routinely performed in patients with acute respiratory distress syndrome (ARDS) to minimize alveolar de-recru... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - June 30, 2023 Category: Surgery Authors: Enrico Bulleri, Cristian Fusi, Stefano Bambi, Luigi Pisani, Alice Galesi, Enrico Rizzello, Alberto Lucchini, Paolo Merlani and Alberto Pagnamenta Tags: Research Articles Source Type: research