Intensive Care Medicine Experimental This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Optimal bispectral index level of sedation and cerebral oximetry in traumatic brain injury: a non-invasive individualized approach in critical care?
Impaired cerebral autoregulation has been linked with worse outcomes, with literature suggesting that current therapy guidelines fail to significantly impact cerebrovascular reactivity. The cerebral oximetry i... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - August 13, 2022 Category: Surgery Authors: Logan Froese, Alwyn Gomez, Amanjyot Singh Sainbhi, Carleen Batson, Trevor Slack, Kevin Y. Stein, Francois Mathieu and Frederick A. Zeiler Tags: Methodologies Source Type: research

Induction of severe hypoxemia and low lung recruitability for the evaluation of therapeutic ventilation strategies: a translational model of combined surfactant-depletion and ventilator-induced lung injury
Models of hypoxemic lung injury caused by lavage-induced pulmonary surfactant depletion are prone to prompt recovery of blood oxygenation following recruitment maneuvers and have limited translational validity... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - July 29, 2022 Category: Surgery Authors: Emilia Boerger, Martin Russ, Philip von Platen, Mahdi Taher, Lea Hinken, Anake Pomprapa, Rainer Koebrich, Frank Konietschke, Jan Adriaan Graw, Burkhard Lachmann, Wolfgang Braun, Steffen Leonhardt, Philipp A. Pickerodt and Roland C. E. Francis Tags: Research Articles Source Type: research

Fast versus slow infusion of 20% albumin: a randomized controlled cross-over trial in volunteers
We investigated whether plasma volume (PV) expansion of 20% albumin is larger when the fluid is administered rapidly compared with a slow infusion. (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - July 18, 2022 Category: Surgery Authors: Markus Zdolsek, Folke Sj öberg and Robert G. Hahn Tags: Research Articles Source Type: research

Closed-loop automated critical care as proof-of-concept study for resuscitation in a swine model of ischemia –reperfusion injury
Volume expansion and vasopressors for the treatment of shock is an intensive process that requires frequent assessments and adjustments. Strict blood pressure goals in multiple physiologic states of shock (tra... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - July 8, 2022 Category: Surgery Authors: Nathan T. P. Patel, Eduardo J. Goenaga-Diaz, Magan R. Lane, M. Austin Johnson, Lucas P. Neff and Timothy K. Williams Tags: Methodologies Source Type: research

Mouse sepsis models: don't forget ambient temperature!
(Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - July 1, 2022 Category: Surgery Authors: Dario Lucas Helbing, Leonie Karoline Stabenow and Reinhard Bauer Tags: Correspondence Source Type: research

Inhaled nitric oxide: role in the pathophysiology of cardio-cerebrovascular and respiratory diseases
Nitric oxide (NO) is a key molecule in the biology of human life. NO is involved in the physiology of organ viability and in the pathophysiology of organ dysfunction, respectively. In this narrative review, we... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - June 27, 2022 Category: Surgery Authors: Davide Signori, Aurora Magliocca, Kei Hayashida, Jan A. Graw, Rajeev Malhotra, Giacomo Bellani, Lorenzo Berra and Emanuele Rezoagli Tags: Reviews Source Type: research

Sex-specific differences in cardiac function, inflammation and injury during early polymicrobial sepsis
Sex differences in sepsis are underexplored and incompletely understood. Cardiac function in early sepsis is pivotal in determining survival; hyperdynamic left ventricular ejection fraction is associated with ... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - June 20, 2022 Category: Surgery Authors: Sophie L. M. Walker, Chand Muthoo, Jenifer Sanchez, Ana Gutierrez Del Arroyo and Gareth L. Ackland Tags: Research Articles Source Type: research

Machine learning approaches to the human metabolome in sepsis identify metabolic links with survival
We examined whether machine learning (ML) tools applied to the human plasma metabolome could consistentl... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - June 17, 2022 Category: Surgery Authors: Leah B. Kosyakovsky, Emily Somerset, Angela J. Rogers, Michael Sklar, Jared R. Mayers, Augustin Toma, Yishay Szekely, Sabri Soussi, Bo Wang, Chun-Po S. Fan, Rebecca M. Baron and Patrick R. Lawler Tags: Research Articles Source Type: research

Extracorporeal immune cell therapy of sepsis: ex vivo results
Immune cell dysfunction plays a central role in sepsis-associated immune paralysis. The transfusion of healthy donor immune cells, i.e., granulocyte concentrates (GC) potentially induces tissue damage via loca... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - June 16, 2022 Category: Surgery Authors: Gerd Klinkmann, Thomas Wild, Benjamin Heskamp, Fanny Doss, Sandra Doss, Lubomir Arseniev, Krasimira Aleksandrova, Martin Sauer, Daniel A. Reuter, Steffen Mitzner and Jens Altrichter Tags: Methodologies Source Type: research

The frailty, outcomes, recovery and care steps of critically ill patients (FORECAST) study: pilot study results
Frailty is common in critically ill patients and is associated with increased morbidity and mortality. There remains uncertainty as to the optimal method/timing of frailty assessment and the impact of care pro... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - June 10, 2022 Category: Surgery Authors: John Muscedere, Sean M. Bagshaw, Gordon Boyd, Stephanie Sibley, Norman Patrick, Andrew Day, Miranda Hunt and Darryl Rolfson Tags: Research Articles Source Type: research

Respiratory system mechanics in one-lung ventilation using double-lumen tubes
(Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - June 2, 2022 Category: Surgery Authors: Jakob Wittenstein, Marcelo Gama de Abreu and Robert Huhle Tags: Letters to the Editor Source Type: research

Intracycle power distribution in a heterogeneous multi-compartmental mathematical model: possible links to strain and VILI
Repeated expenditure of energy and its generation of damaging strain are required to injure the lung by ventilation (VILI). Mathematical modeling of passively inflated, single-compartment lungs with uniform pa... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - June 1, 2022 Category: Surgery Authors: Philip S. Crooke, Luciano Gattinoni, Michael Michalik and John J. Marini Tags: Research Articles Source Type: research

Simple, accurate calculation of mechanical power in pressure controlled ventilation (PCV)
Mechanical power is a promising new metric to assess energy transfer from a mechanical ventilator to a patient, which combines the contributions of multiple parameters into a single comprehensive value. Howeve... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - May 30, 2022 Category: Surgery Authors: Christine A. Trinkle, Richard N. Broaddus, Jamie L. Sturgill, Christopher M. Waters and Peter E. Morris Tags: Methodologies Source Type: research

Hydrocephalus and the neuro-intensivist: CSF hydrodynamics at the bedside
Hydrocephalus (HCP) is far more complicated than a simple disorder of cerebrospinal fluid (CSF) circulation. HCP is a common complication in patients with subarachnoid hemorrhage (SAH) and after craniectomy. C... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - May 27, 2022 Category: Surgery Authors: Vasilios Papaioannou, Zofia Czosnyka and Marek Czosnyka Tags: Reviews Source Type: research

Flow-controlled ventilation in moderate acute respiratory distress syndrome due to COVID-19: an open-label repeated-measures controlled trial
Flow-controlled ventilation (FCV), a novel mode of mechanical ventilation characterised by constant flow during active expiration, may result in more efficient alveolar gas exchange, better lung recruitment an... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - May 24, 2022 Category: Surgery Authors: Eleni D. Van Dessel, Gregory R. De Meyer, Stuart G. Morrison, Philippe G. Jorens and Tom Schepens Tags: Research Articles Source Type: research