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Plasma proenkephalin A 119 –159 on intensive care unit admission is a predictor of organ failure and 30-day mortality
Proenkephalin A 119-159 (penKid) has been suggested as a marker of renal failure and poor outcome. We aimed to investigate the association of penKid on ICU admission with organ dysfunction and mortality in a m... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - July 19, 2021 Category: Surgery Authors: Attila Frigyesi, Lisa Bostr öm, Maria Lengquist, Patrik Johnsson, Oscar H. M. Lundberg, Martin Spångfors, Martin Annborn, Tobias Cronberg, Niklas Nielsen, Helena Levin and Hans Friberg Tags: Research Articles Source Type: research

Pulmonary and intestinal microbiota dynamics during Gram-negative pneumonia-derived sepsis
The gut microbiome plays a protective role in the host defense against pneumonia. The composition of the lung microbiota has been shown to be predictive of clinical outcome in critically ill patients. However,... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - July 12, 2021 Category: Surgery Authors: Nora S. Wolff, Max C. Jacobs, W. Joost Wiersinga and Floor Hugenholtz Tags: Research Articles Source Type: research

Induced hypernatremia in patients with moderate-to-severe ARDS: a randomized controlled study
Induced hypernatremia and hyperosmolarity is protective in animal models of lung injury. We hypothesized that increasing and maintaining plasma sodium between 145 and 150 mmol/l in patients with moderate-to-se... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - July 5, 2021 Category: Surgery Authors: Shailesh Bihari, Shivesh Prakash, Dani L. Dixon, Elena Cavallaro and Andrew D. Bersten Tags: Research Articles Source Type: research

The Surviving Sepsis Campaign: research priorities for the administration, epidemiology, scoring and identification of sepsis
To identify priorities for administrative, epidemiologic and diagnostic research in sepsis. (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - July 2, 2021 Category: Surgery Authors: Mark E. Nunnally, Ricard Ferrer, Greg S. Martin, Ignacio Martin-Loeches, Flavia R. Machado, Daniel De Backer, Craig M. Coopersmith and Clifford S. Deutschman Tags: Reviews Source Type: research

Risk factors for adverse outcomes during mechanical ventilation of 1152 COVID-19 patients: a multicenter machine learning study with highly granular data from the Dutch Data Warehouse
The identification of risk factors for adverse outcomes and prolonged intensive care unit (ICU) stay in COVID-19 patients is essential for prognostication, determining treatment intensity, and resource allocat... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - June 28, 2021 Category: Surgery Authors: Lucas M. Fleuren, Michele Tonutti, Daan P. de Bruin, Robbert C. A. Lalisang, Tariq A. Dam, Diederik Gommers, Olaf L. Cremer, Rob J. Bosman, Sebastiaan J. J. Vonk, Mattia Fornasa, Tomas Machado, Nardo J. M. van der Meer, Sander Rigter, Evert-Jan Wils, Tim Tags: Research Articles Source Type: research

Preservation of renal endothelial integrity and reduction of renal edema by aprotinin does not preserve renal perfusion and function following experimental cardiopulmonary bypass
Acute kidney injury is a severe complication following cardiopulmonary bypass (CPB) and is associated with capillary leakage and microcirculatory perfusion disturbances. CPB-induced thrombin release results in... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - June 25, 2021 Category: Surgery Authors: Nicole A. M. Dekker, Anoek L. I. van Leeuwen, Matijs van Meurs, Jill Moser, Jeannette E. Pankras, Nicole N. van der Wel, Hans W. Niessen, Marc G. Vervloet, Alexander B. A. Vonk, Peter L. Hordijk, Christa Boer and Charissa E. van den Brom Tags: Research Articles Source Type: research

A 29-mRNA host response test from blood accurately distinguishes bacterial and viral infections among emergency department patients
Whether or not to administer antibiotics is a common and challenging clinical decision in patients with suspected infections presenting to the emergency department (ED). We prospectively validate InSep, a 29-m... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - June 18, 2021 Category: Surgery Authors: Asimina Safarika, James W. Wacker, Konstantinos Katsaros, Nicky Solomonidi, George Giannikopoulos, Antigone Kotsaki, Ioannis M. Koutelidakis, Sabrina M. Coyle, Henry K. Cheng, Oliver Liesenfeld, Timothy E. Sweeney and Evangelos J. Giamarellos-Bourboulis Tags: Research Articles Source Type: research

Endothelial cell regulation of systemic haemodynamics and metabolism acts through the HIF transcription factors
The vascular endothelium has important endocrine and paracrine roles, particularly in the regulation of vascular tone and immune function, and it has been implicated in the pathophysiology of a range of cardio... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - June 11, 2021 Category: Surgery Authors: Simon Lambden, Andrew S. Cowburn, David Macias, Tessa A. C. Garrud, Bernardo J. Krause, Dino A. Giussani, Charlotte Summers and Randall S. Johnson Tags: Research Articles Source Type: research

Norepinephrine and dobutamine improve cardiac index equally by supporting opposite sides of the heart in an experimental model of chronic pulmonary hypertension
Pulmonary hypertension is a significant risk factor in patients undergoing surgery. The combined effects of general anaesthesia and positive pressure ventilation can aggravate this condition and cause increase... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - June 4, 2021 Category: Surgery Authors: Janus Adler Hyldebrandt, Nikolaj B øgh, Camilla Omann and Peter Agger Tags: Research Articles Source Type: research

Dynamic compliance in flow-controlled ventilation
(Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - May 31, 2021 Category: Surgery Authors: Dietmar Enk, Julia Abram, Patrick Spraider and Tom Barnes Tags: Correspondence Source Type: research

Continuous intra-gastral monitoring of intra-abdominal pressure in critically ill children: a validation study
In critically ill children, detection of intra-abdominal hypertension (IAH  > 10 mmHg) and abdominal compartment syndrome (ACS = IAH + organ dysfunction) is paramount and usually monitored through intra-vesical... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - May 24, 2021 Category: Surgery Authors: T. Kaussen, M. Gutting, F. Lasch, D. Boethig, A. von Gise, J. Dingemann, H. Koeditz, T. Jack, M. Sasse, P. Beerbaum and M. Boehne Tags: Research Articles Source Type: research

The effect of targeting Tie2 on hemorrhagic shock-induced renal perfusion disturbances in rats
Hemorrhagic shock is associated with acute kidney injury and increased mortality. Targeting the endothelial angiopoietin/Tie2 system, which regulates endothelial permeability, previously reduced hemorrhagic sh... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - May 17, 2021 Category: Surgery Authors: Anoek L. I. van Leeuwen, Nicole A. M. Dekker, Paul Van Slyke, Esther de Groot, Marc G. Vervloet, Joris J. T. H. Roelofs, Matijs van Meurs and Charissa E. van den Brom Tags: Research Articles Source Type: research

Tissue adhesives for bacterial inhibition in extracorporeal membrane oxygenation cannulae
One of the most serious complications of extracorporeal membrane oxygenation (ECMO) therapy is ECMO cannulae infection, which can occur at quadruple the rate of central venous catheter infections, and signific... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - May 10, 2021 Category: Surgery Authors: India Pearse, Amanda Corley, Yue Qu and John Fraser Tags: Research Articles Source Type: research

Sepsis: deriving biological meaning and clinical applications from high-dimensional data
The pathophysiology of sepsis is multi-facetted and highly complex. As sepsis is a leading cause of global mortality that still lacks targeted therapies, increased understanding of its pathogenesis is vital fo... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - May 7, 2021 Category: Surgery Authors: Alex R. Schuurman, Tom D. Y. Reijnders, Robert F. J. Kullberg, Joe M. Butler, Tom van der Poll and W. Joost Wiersinga Tags: Reviews Source Type: research

Haptoglobin treatment prevents cell-free hemoglobin exacerbated mortality in experimental rat sepsis
(Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - May 3, 2021 Category: Surgery Authors: Christian A. Schaer, Victor Jeger, Thomas Gentinetta, Donat R. Spahn, Florence Vallelian, Alain Rudiger and Dominik J. Schaer Tags: Letters to the Editor Source Type: research