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Condition: Hypothermia

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Total 450 results found since Jan 2013.

DEcompressive surgery Plus hypoTHermia for Space‐Occupying Stroke (DEPTH‐SOS): a protocol of a multicenter randomized controlled clinical trial and a literature review
DiscussionThe results of this trial will provide data on safety and feasibility of moderate hypothermia in addition to decompressive hemicraniectomy in malignant middle cerebral artery infarction. Furthermore, efficacy data on early mortality and long‐term functional outcome will be obtained, forming the basis of subsequent trials.
Source: International Journal of Stroke - June 20, 2013 Category: Neurology Authors: Hermann Neugebauer, Rainer Kollmar, Wolf‐Dirk Niesen, Julian Bösel, Hauke Schneider, Carsten Hobohm, Klaus Zweckberger, Peter U. Heuschmann, Peter D. Schellinger, Eric Jüttler, Tags: Protocol Source Type: research

Drug-induced Hypothermia by 5HT Agonists Provide Neuroprotection in Experimental Stroke: New Perspectives for Acute Patient Treatment
Drug-induced hypothermia reduces brain damage in animal stroke models and is an undiscovered potential in human stroke treatment. We studied hypothermia induced by the serotonergic agonists S14671 (1-[2-(2-thenoylamino)ethyl]-4[1-(7- methoxynaphtyl)]piperazine) and ipsapirone in a rat stroke model and in man by literature meta-analysis.
Source: Journal of Stroke and Cerebrovascular Diseases - October 9, 2014 Category: Neurology Authors: Flemming Fryd Johansen, Henrik Hasseldam, Matthias Nybro Smith, Rune Skovgaard Rasmussen Source Type: research

Strategies for therapeutic hypometabothermia.
Authors: Liu S, Chen JF Abstract Although therapeutic hypothermia and metabolic suppression have shown robust neuroprotection in experimental brain ischemia, systemic complications have limited their use in treating acute stroke patients. The core temperature and basic metabolic rate are tightly regulated and maintained in a very stable level in mammals. Simply lowering body temperature or metabolic rate is actually a brutal therapy that may cause more systemic as well as regional problems other than providing protection. These problems are commonly seen in hypothermia and barbiturate coma. The main innovative conc...
Source: Journal of Experimental Stroke and Translational Medicine - December 2, 2015 Category: Neurology Tags: J Exp Stroke Transl Med Source Type: research

In cold blood: intraarteral cold infusions for selective brain cooling in stroke
Sven Poli
Source: Journal of Cerebral Blood Flow - February 12, 2014 Category: Neurology Authors: Elga EspositoMatthias EbnerUlf ZiemannSven Poli Tags: stroke cardiac arrest hypothermia intraarterial cold infusions neuroprotection selective brain cooling Source Type: research

Therapeutic Hypothermia (Different Depths, Durations, and Rewarming Speeds) for Acute Ischemic Stroke: A Meta-analysis
Whether therapeutic hypothermia benefits patients with acute ischemic stroke (AIS) remains controversial. The aim of this study was to evaluate the efficacy and safety of the different depths, durations, and rewarming speeds of therapeutic hypothermia for AIS.
Source: Journal of Stroke and Cerebrovascular Diseases - September 17, 2014 Category: Neurology Authors: Yue-Hong Wan, Chen Nie, Hui-Ling Wang, Chao-Yun Huang Source Type: research

Hypoxic-ischemic neonatal encephalopathy: animal experiments for neuroprotective therapies.
Authors: Sameshima H, Ikenoue T Abstract Hypoxic-ischemic neonatal encephalopathy and ensuing brain damage is still an important problem in modern perinatal medicine. In this paper, we would like to share some of the results of our recent studies on neuroprotective therapies in animal experiments, as well as some literature reviews. From the basic animal studies, we have now obtained some possible candidates for therapeutic measures against hypoxic-ischemic neonatal encephalopathy. For example, they are hypothermia, rehabilitation, free radical scavenger, neurotrophic factors and growth factors, steroid, calcium ch...
Source: Stroke Research and Treatment - December 2, 2014 Category: Neurology Tags: Stroke Res Treat Source Type: research

Intracranial pressure elevation after ischemic stroke in rats: cerebral edema is not the only cause, and short-duration mild hypothermia is a highly effective preventive therapy
ae & Neil J Spratt
Source: Journal of Cerebral Blood Flow - December 17, 2014 Category: Neurology Authors: Lucy A MurthaDamian D McLeodDebbie PepperallSarah K McCannDaniel J BeardAmelia J TomkinsWilliam M HolmesChristopher McCabeI Mhairi MacraeNeil J Spratt Tags: cerebral edema hypothermia intracranial pressure ischemic stroke rats Source Type: research

Letter by Mattingly et al Regarding Article, “Endovascular Hypothermia in Acute Ischemic Stroke: Pilot Study of Selective Intra-Arterial Cold Saline Infusion” Letter to the Editor
Source: Stroke - October 23, 2016 Category: Neurology Authors: Mattingly, T. K., Lownie, S. P., Pelz, D. M. Tags: Ischemic Stroke, Neuroprotectants Letters to the Editor Source Type: research

Response by Chen et al to Letter Regarding Article, “Endovascular Hypothermia in Acute Ischemic Stroke: A Pilot Study of Selective Intra-Arterial Cold Saline Infusion” Letter to the Editor
Source: Stroke - October 23, 2016 Category: Neurology Authors: Chen, J., Ding, Y., Ji, X. Tags: Revascularization, Ischemic Stroke Letters to the Editor Source Type: research

Effect of Inflammation on the Process of Stroke Rehabilitation and Poststroke Depression
Conclusions Stroke comprises ischemic stroke and ICH. The immuno-inflammatory process is involved in neural plasticity following events such as a hemorrhage or ischemic stroke. After ischemia, astrocytes, microglia, and MDMs play important roles during rehabilitation with the modulation of cytokines or chemokines, such as TNF-α and IL-1. Moreover, MiRNAs are also important posttranscriptional regulators in these glial mitochondrial responses to cerebral ischemia. ICH involves processes similar and different to those seen in ischemia, including neuronal injury, astrocytic and microglial/macrophage activation, and n...
Source: Frontiers in Psychiatry - April 10, 2019 Category: Psychiatry Source Type: research

What Are the Classifications of Perinatal Stroke?
Discussion Perinatal stroke occurs in about 1:1000 live births and is a “focal vascular injury from the fetal period to 28 days postnatal age.” Perinatal stroke is the most common cause of hemiparetic cerebral palsy and causes other significant morbidity including cognitive deficits, learning disabilities, motor problems, sensory problems including visual and hearing disorders, epilepsy, and behavioral and psychological problems. Family members are also affected because of the potential anxiety and guilt feelings that having a child with a stroke presents, along with the care that may be needed over the child&#...
Source: PediatricEducation.org - May 1, 2023 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Therapeutic hypothermia and ischemic stroke: A literature review.
CONCLUSION: Although hypothermia has been used for various purposes over several decades, its efficacy in the treatment of ischemic stroke is debatable. Several trials have proven its safety and feasibility; however, more robust, randomized clinical trials with large volumes of patients are needed to fully establish its utility in the clinical setting. PMID: 27313963 [PubMed]
Source: Surgical Neurology International - June 19, 2016 Category: Neurosurgery Tags: Surg Neurol Int Source Type: research

Distinguishing Arterial Ischemic Stroke From Hypoxic-Ischemic Encephalopathy in the Neonate at Birth.
CONCLUSION: Stroke is associated with increased initial platelet counts and is not associated with cesarean delivery for nonreassuring fetal heart rate tracings, sentinel events, or perinatal metabolic acidosis. Stroke is a form of neonatal brain injury not associated with perinatal risk factors that allow early identification. PMID: 27607878 [PubMed - as supplied by publisher]
Source: Obstetrics and Gynecology - September 4, 2016 Category: OBGYN Authors: Adami RR, Grundy ME, Poretti A, Felling RJ, Lemmon M, Graham EM Tags: Obstet Gynecol Source Type: research

Selective endovascular cooling for stroke entails brain-derived neurotrophic factor and splenic IL-10 modulation.
Abstract Stroke poses a serious health and economic burden, and the lack of treatment options necessitates a viable therapy. Hypothermia represents a promising stroke therapy, yet side effects of full-body cooling, such as pneumonia, limit its clinical application. Selective endovascular cooling (SEC), via infusion of cold saline through the intraarterial artery, represents an attractive alternative by locally cooling the brain while preserving body temperature. However, the mechanisms underlying SEC are poorly understood. Brain-derived neurotrophic factor (BDNF) is a widely recognized promotor of neuroplasticity ...
Source: Brain Research - August 11, 2019 Category: Neurology Authors: Corey S, Abraham DI, Kaneko Y, Lee JY, Borlongan CV Tags: Brain Res Source Type: research