Kidney Disease and Epilepsy
The family of a 47-year-old man with end stage renal failure on hemodialysis brought him to the emergency room. He had missed 3 sessions of dialysis due to concerns for COVID-19 precautions. He had developed increasing confusion and generalized weakness. Examination showed altered mental status and disorientation to date and place. He had bilateral gaze evoked nystagmus and asterixis in his upper extremities. His lab work showed Blood Urea Nitrogen (BUN) of 75  mg/dL and Creatinine of 6.2 mg/dL. His EEG showed generalized triphasic waves (Fig. 1). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - February 10, 2021 Category: Neurology Authors: Mona Sazgar Source Type: research

Neuropathologic Findings in Chronic Kidney Disease (CKD)
Studying the neuropathologic autopsy findings in subjects with chronic kidney disease (CKD) or chronic renal failure (CRF) is difficult for several reasons: etiology of the CKD may be heterogeneous, affected patients may have one or more major co-morbidities that themselves can cause significant neurologic disease, and agonal events may result in significant findings that were of minimal significance earlier in a patient's life. We studied the constellation of neuropathologic abnormalities in 40 autopsy brains originating from subjects of ages 34-95 years (no children in the study). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - February 10, 2021 Category: Neurology Authors: Harry V. Vinters, Shino D. Magaki, Christopher Kazu Williams Source Type: research

Diagnostic accuracy of dysphagia screening in stroke care: Answer to the Letter by Toscano et  al.
The Letter by Toscano and colleagues raises some interesting points. We are grateful to them for giving us the possibility to discuss three major questions as to the diagnostic accuracy of our dysphagia screening test in stroke patients. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - February 10, 2021 Category: Neurology Authors: Paolo Immovilli, Eugenia Rota, Chiara Terracciano, Nicola Morelli, Elena Marchesi, Domenica Zaino, Nicola Mometto, Donata Guidetti Tags: Letter to the Editor Source Type: research

Masthead
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - February 9, 2021 Category: Neurology Source Type: research

Editorial Board
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - February 9, 2021 Category: Neurology Source Type: research

Table of Contents
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - February 9, 2021 Category: Neurology Source Type: research

Letter to the Editor Regarding "Diagnostic Accuracy of a Bedside Screening Tool for Dysphagia ”
We read with great interest the article by Immovilli et  al.1 aimed at developing a bedside examination to identify the risk of dysphagia in stroke patients. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - February 9, 2021 Category: Neurology Authors: Massimiliano Toscano, Alessandro Vigan ò, Tommaso B. Jannini, Marco Ruggiero, Angela Comanducci, Vittorio Di Piero Tags: Letter to the Editor Source Type: research

Corrigendum to ‘Health Behaviors among Stroke Survivors in the United States: A Propensity Score-Matched Study’ [Journal of Stroke & Cerebrovascular Diseases, Vol. 27, No. 8 (August), 2018: pp 2124 –2133]
The authors regret to inform the readers that there was an unnoticed mistake in the paper. An affiliation of Dr. Wali was not listed at the time of publication due to an oversight from the author. The aforementioned missing affiliation is the following: Department of Pharmacy Practice, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, Saudi Arabia. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - February 9, 2021 Category: Neurology Authors: Haytham Wali, Sawsan Kurdi, Jawad Bilal, Irbaz Bin Riaz, Sandipan Bhattacharjee Tags: Corrigendum Source Type: research

Adaptive approach to endovascular management of large vessel occlusion during the COVID-19 pandemic
The COVID-19 pandemic has resulted in unprecedented strain on the health care system. An adaptive strategy for the handling of thrombectomy for patients with large vessel occlusion has evolved at our center to optimize patient care while also minimizing risk of virus transmission. The purpose of this study was to evaluate the effects of the new thrombectomy protocol by comparing thrombectomy times and patient outcomes during the pandemic and pre pandemic period. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 29, 2021 Category: Neurology Authors: Borna Ethan Tabibian, Sasha G. Howell, Arsalaan Salehani, Ekaterina Bakradze, Mark Harrigan Source Type: research

Response to letter by Dr. Mammi et al.
Rima M. Dafer, Nicholas Osteraas, Jose Biller (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 26, 2021 Category: Neurology Source Type: research

Impact of the COVID-19 pandemic on stroke epidemiology and clinical stroke practice in the US
: To examine the impact of the COVID-19 pandemic on stroke, the number of stroke patients, time since last known well (LKW), morbidity, and mortality of stroke patients in Southwest Healthcare System (SHS), California (CA) and the United States (US) were analyzed during 2019 and compared to 2020. Our hypothesis is that there are regional differences in stroke outcome depending on location during the COVID-19 study period which influences stroke epidemiology and clinical stroke practice. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 26, 2021 Category: Neurology Authors: Daniel Friedlich, Tali Newman, Stephanie Bricker Source Type: research

Reply to: Response to “measuring the optic nerve sheath diameter with ultrasound in acute middle cerebral artery stroke patients”: For application to Long-Duration Spaceflight (LDSF)
We thank Mohanadass and Church for their interest in using Optic Nerve Sheath Diameter (ONSD) measurements in Acute Middle Cerebral Artery (MCA) stroke patients to evaluate the effect of thrombolytic therapy and identify high-risk patients.1 (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 23, 2021 Category: Neurology Authors: Seda G üzeldağ, Gökhan Yılmaz Tags: Letter to the Editor Source Type: research

Response to “Measuring the Optic Nerve Sheath Diameter with Ultrasound in Acute Middle Cerebral Artery Stroke Patients”: For Application to Long-Duration Spaceflight (LDSF)
We thank the authors of the study for their contribution to literature and their insights into the utilisation of optic nerve sheath diameter (ONSD) measurements with regards to therapeutic efficacy of thrombolytic therapy (TT) and identification of complications in populations post-MCA stroke. We would like to introduce the discussion of potential translational benefits of this methodology to the field of long-duration spaceflight (LDSF). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 20, 2021 Category: Neurology Authors: Chloe A. Mohanadass, Lauren E. Church Tags: Letter to the Editor Source Type: research

IAT-TiMeS: Intra-Arterial Thrombectomy Transfer Metric Study in Texas
We aim to report intra-arterial thrombectomy transfer metrics for ischemic stroke patients that were transferred to hub hospitals for possible intra-arterial thrombectomy in multiple geographic regions throughout the state of Texas and to identify potential barriers and delays in the intra-arterial thrombectomy transfer process. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 15, 2021 Category: Neurology Authors: Tzu-Ching Wu, Christy Ankrom, Michele Joseph, Alyssa Trevino, Liang Zhu, Steven Warach, Roberta R. Novakovic, Mark P. Goldberg, Lee A. Birnbaum, Osman Mir, Gustavo J. Rodriguez, Yazan J. Alderazi, Ameer E. Hassan, Sean I. Savitz Source Type: research

The Utility of the Markers of Coagulation and Hemostatic Activation Profile in the Management of Embolic Strokes of Undetermined Source
Potential causes of embolic stroke of undetermined source (ESUS) include occult malignancy, venous thrombosis (VTE) with paradoxical embolism, and hypercoagulable disorders. Given the association of markers of coagulation and hemostatic activation (MOCHA) with these causes, the objective of this study was to validate the utility of the MOCHA profile in identifying the underlying cause of stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 14, 2021 Category: Neurology Authors: Michael Liu, Deandrea Ellis, Alexander Duncan, Samir Belagaje, Trina Belair, Laura Henriquez, Srikant Rangaraju, Fadi Nahab Source Type: research

Elevated Levels of Inflammation Markers Predict Poor Outcomes in Acute Ischemic Stroke Patients After Intravenous Thrombolysis
Inflammation is associated with the occurrence and prognosis of ischemic stroke. The aim of this study was to evaluate the association between inflammatory biomarkers and the short-term clinical outcomes of acute ischemic stroke (AIS) patients after intravenous thrombolysis (IVT). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 12, 2021 Category: Neurology Authors: Dan Hu, Caixia Ding, Xuemei Jiang, Jing Xiao, Chuanyou Li, Lankun Zhang, Tingting Li, Yun Ji, Yuan Peng, Xun Luo, Lei Sheng, Qingmei Wang, Haoxin Wu Source Type: research

Determination of Cerebrovascular Accident Predictors in Patients with New-Onset Atrial Fibrillation After Coronary Artery Bypass Graft Surgery
Postoperative atrial fibrillation (POAF) is associated with an increased risk of short and long-term stroke. Our aim is to identify the independent predictors of cerebrovascular accident (CVA) development in the patients who underwent isolated coronary artery bypass graft (CABG) surgery and developed POAF which lasted within 48  h. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 12, 2021 Category: Neurology Authors: Ali Riza Demir, Omer Celik, Begum Uygur, Mustafa Umut Somuncu, Emre Yilmaz, Yalcin Avci, Muhammed Bayram, Mehmet Erturk Source Type: research

Continuous Glibenclamide Prevents Hemorrhagic Transformation in a Rodent Model of Severe Ischemia-Reperfusion
Endovascular thrombectomy (EVT) is highly effective but may also lead to hemorrhagic transformation (HT) and edema, which may be more pronounced in severe ischemia. We sought to determine whether glibenclamide can attenuate HT and edema in a severe ischemia-reperfusion model that reflects EVT. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 12, 2021 Category: Neurology Authors: Takahiro Igarashi, Cristina Sastre, Zoe Wolcott, W. Taylor Kimberly Source Type: research

Impact of the Perioperative Blood Pressure on Clinical Outcome after Thrombectomy in Acute Basilar Artery Occlusion
Aim: Optimal blood pressure (BP) management in vertebrobasilar circulation stroke patients undergoing thrombectomy remains undetermined. We  aimed to evaluate the impact of perioperative BP on clinical outcome after MT in acute basilar artery occlusion (BAO) patients. Methods: We retrospectively analyzed all consecutive patients hospitalized with acute basilar artery occlusion administered endovascular treatment within 24 h from Jan uary 2012 to July 2018 in Beijing Tiantan Hospital. BP was measured at regular intervals during the first 24 h after stroke onset, during and after thrombectomy. (Sourc...
Source: Journal of Stroke and Cerebrovascular Diseases - January 9, 2021 Category: Neurology Authors: Bin Han, Xuan Sun, Raynald Liu, Xu Tong, Baixue Jia, Dapeng Mo, Xiaoqing Li, Gang Luo, Zhongrong Miao Source Type: research

An fMRI, DTI and Neurophysiological Examination of Atypical Organization of Motor Cortex in Ipsilesional Hemisphere Following Post-Stroke Recovery
We report a 61-year-old woman who developed left hemiparesis following a right frontal stroke. She underwent rehabilitation and regained function of the left side of her body. Three years after her first stroke, she developed a large left subdural hematoma and again presented with left hemiparesis. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 9, 2021 Category: Neurology Authors: Layla Gould, Shaylyn Kress, Josh Neudorf, Katherine Gibb, Amit Persad, Kotoo Meguro, Jonathan Norton, Ron Borowsky Tags: Case Report Source Type: research

Coronavirus Positive Patients Presenting with Stroke-Like Symptoms
Several studies from Wuhan, China have reported neurological manifestations in patients who tested positive for coronavirus disease 2019 (COVID-19). One study reported 214 COVID-19 positive patients, out of which 41.1% had severe infection. 5.7% of patients with severe infection had acute cerebrovascular disease1. Another study looked at 221 COVID-19 positive patients, out of which 5% had ischemic infarcts and 0.5% had cerebral hemorrhage2. A recent study from Mount Sinai Hospital in New York reported five cases of cerebral infarcts due to large vessel occlusion in patients who tested positive for COVID-19. (Source: Journa...
Source: Journal of Stroke and Cerebrovascular Diseases - January 9, 2021 Category: Neurology Authors: Shaista Alam, Robin N. Dharia, Elan Miller, Fred Rincon, Diana L. Tzeng, Rodney D. Bell Source Type: research

Carotid Endarterectomy is often not Possible after an Unheralded Stroke: Unheralded Stroke in Carotid Artery Stenosis
The ongoing literature recommends carotid endarterectomy (CEA) primarily for patients with neurological symptoms, however CEA can be precluded by the onset of a severe stroke or a total carotid occlusion. The present study aims to evaluate the effect of unheralded strokes in patients with a previously asymptomatic carotid stenosis (ACS) possibly considered for CEA. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 8, 2021 Category: Neurology Authors: Rodolfo Pini, Gianluca Faggioli, Antonio Muscari, Cristina Rocchi, Sergio Palermo, Andrea Vacirca, Enrico Gallitto, Mauro Gargiulo Source Type: research

Masthead
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 7, 2021 Category: Neurology Source Type: research

Editorial Board
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 7, 2021 Category: Neurology Source Type: research

Table of Contents
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 7, 2021 Category: Neurology Source Type: research

Intracranial Hemorrhage in COVID-19 Patients
To describe the clinical, laboratory, temporal, radiographic, and outcome features of acute Intracranial Hemorrhage (ICH) in COVID-19 patients. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 7, 2021 Category: Neurology Authors: Sanskriti Mishra, Murray Choueka, Qiang Wang, Chloe Hu, Stephanie Visone, Michael Silver, Evan G. Stein, Steven R. Levine, Qingliang T. Wang Source Type: research

Bilateral large vessel occlusion causing massive ischemic stroke in a covid-19 patient
The case of a 70-year-old male presenting an ischemic stroke related to COVID-19 infection is described. He was initially admitted to the hospital with respiratory insufficiency syndrome secondary to pneumonia caused by SARS Co2. In the next days, he developed rapid neurological deterioration characterized by drowsiness which progressed to deep coma. D-dimer was elevated. Brain CT scan showed bilateral massive ischemic stroke located in the anterior circulation, CT angiogram showed occlusion in the left internal carotid artery and the right middle cerebral artery. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 7, 2021 Category: Neurology Authors: Luis A. Robles Tags: Case Report Source Type: research

The Association between Cerebral Small Vessel Disease and the Gut Microbiome: A Cross-Sectional Analysis
Cerebral small vessel disease (SVD) has been a research focus as a risk factor for both stroke and dementia.1 Cerebral SVD is characterised by brain magnetic resonance imaging (MRI) abnormalities, as silent lacunar infarcts (SLIs), white matter hyperintensities (WMHs), cerebral microbleeds (CMBs), and enlarged periventricular spaces (EPVSs).1 These findings are frequently encountered in patients with vascular risk factors, and are also common in patients with early stages of cognitive impairment. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 7, 2021 Category: Neurology Authors: Naoki Saji, Kenta Murotani, Takayoshi Hisada, Tsuyoshi Tsuduki, Taiki Sugimoto, Ai Kimura, Shumpei Niida, Kenji Toba, Takashi Sakurai Source Type: research

Adoption of the Transradial Approach for Neurointerventions: A National Survey of Current Practitioners
The transradial approach (TRA) has been demonstrated to reduce mortality, morbidity, access-site complications, hospital cost, and hospital length of stay when compared to the transfemoral approach (TFA) in multiple cardiac trials.1-6 The approach is technically feasible for both diagnostic7 and therapeutic8,9 neurointerventions. Patients strongly prefer procedures done via TRA,10,11 likely due to increased postprocedural comfort. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 6, 2021 Category: Neurology Authors: Somnath Das, Sunidhi Ramesh, Lohit Velagapudi, Ahmad Sweid, Reid Gooch, Stavropoula Tjoumakaris, Robert H. Rosenwasser, Pascal Jabbour Source Type: research

Factor XII Concentrations and Risk of Intracerebral Haemorrhage. A Prospective Case-Referent Study
Intracerebral haemorrhage (ICH) accounts for about 15% of all stroke in Sweden and is associated with high rates of death and disability.1,2 Biomarkers can be used in predicting disease risk as well as for disease diagnosis and prognosis estimation.3 A range of biomarkers have been studied in relationship to risk of ICH.4-7 (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 5, 2021 Category: Neurology Authors: Kristina Johansson, Lars Johansson, Torbj örn K. Nilsson, Marcus M. Lind Source Type: research

Association Between the Angiotensin-Converting Enzyme I/D Polymorphism and Risk of Cerebral Small Vessel Disease: A Meta-Analysis Based on 7186 Subjects
Cerebral small vessel disease (CSVD) causes a quarter of all strokes and is the most common pathology underlying vascular dementia. However, the mechanism of CSVD remains unclear. Numerous studies have investigated whether the angiotensin-converting enzyme (ACE) intersection/deletion (I/D) polymorphism influences the risk of CSVD, but the results are controversial. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 5, 2021 Category: Neurology Authors: Cheng Su, Wen-Chen Liu, Guo-Ming Li, Yan Huang Source Type: research

4-Hydroxyl-2-Nonenal Localized Expression Pattern in Retrieved Clots is Associated with Large Artery Atherosclerosis in Stroke Patients
The relationship between stroke etiology and clot pathology remains controversial. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 5, 2021 Category: Neurology Authors: Yosuke Osakada, Toru Yamashita, Ryuta Morihara, Namiko Matsumoto, Ryo Sasaki, Koh Tadokoro, Emi Nomura, Yuko Kawahara, Yoshio Omote, Nozomi Hishikawa, Mami Takemoto, Yasuyuki Ohta, Yasuki Suruga, Takayuki Nagase, Yuji Takasugi, Satoshi Inoue, Kyoichi Wata Source Type: research

Temporal Evolution and Outcomes of Non-Traumatic Intracerebral Hemorrhage in Hospitalized Patients
To investigate the radiographic features, temporal evolution, and outcome of patients who develop non-traumatic intracerebral hemorrhage (ICH) while hospitalized for other causes. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 5, 2021 Category: Neurology Authors: Andrea Loggini, Faten El Ammar, Issam A. Awad, Christos Lazaridis, Christopher L. Kramer, Christi Kordeck, Cedric McKoy, Fernando D. Goldenberg, Ali Mansour Source Type: research

Clinical Trial of the New Stent Retriever Tron FX for both Proximal and Distal Intracranial Large Vessel Occlusions
Five randomized controlled trials (RCTs)1 –5 of mechanical thrombectomy (MT) to treat large vessel occlusion (LVO) within 6 to 12 h, and 2 RCTs6,7 within 6–24 h of time last known well have clarified the its efficacy, and acute MT has spread widely and rapidly. However, the target vessels in these studies were mainly proximal large ves sels such as the intracranial internal carotid artery (ICA) and the M1 portion of the middle cerebral artery (MCA). Although the effectiveness of MT for M2/3 portion of MCA has been reported in meta-analysis8 and retrospective multicenter cohort9 studies, RCTs have not yet b...
Source: Journal of Stroke and Cerebrovascular Diseases - January 5, 2021 Category: Neurology Authors: Hirotoshi Imamura, Nobuyuki Sakai, Hiroshi Yamagami, Tetsu Satow, Yasushi Matsumoto, Keisuke Imai, Shinzo Ota, Nobutaka Horie, Rei Kondo, Yukiko Enomoto, Shinichi Yoshimura, Masaru Hirohata, Masunari Shibata, Yuji Matsumaru, Nobuyuki Ohara, Chiaki Sakai, Source Type: research

Adherence to Acute Care Measures Affects Mortality in Patients with Ischemic Stroke: The Florida Stroke Registry
Racial/ethnic disparities are recognized across all aspects of acute stroke care and underscored as an important research priority.1 –3 It has long been known that ischemic stroke has a disproportionate impact on clinical outcomes and stroke related mortality across different race/ethnic groups.4 The variations in stroke outcomes are thought to be multifactorial and in part related to differences in risk factor prevalence, reco gnition, potency and premorbid treatment of vascular related disorders in combination with age, socioeconomic status and access to care amongst different race/ethnic groups. (Source: Journal o...
Source: Journal of Stroke and Cerebrovascular Diseases - January 5, 2021 Category: Neurology Authors: Hannah Gardener, Tatjana Rundek, Judith Lichtman, Erica Leifheit, Kefeng Wang, Negar Asdaghi, Jose G. Romano, Ralph L. Sacco Source Type: research

Traumatic Distal Anterior Cerebral Artery Aneurysms – Pathomechanism and Revascularisation Strategies
The objective of this work was to discuss the mechanisms of TICA formation of the dACA and to elucidate the best treatment and revascularization strategies in these patients based on two illustrative cases. Case 1: 20-year-old patient with a traumatic, partially thrombosed 14  × 10 mm aneurysm of the right pericallosal artery (rPericA), distal to the origin of the right callosomarginal artery (rCMA). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 2, 2021 Category: Neurology Authors: Julia Velz, Giuseppe Esposito, Luca Regli Source Type: research

Gaze Deviation and Paresis Score (GPS) Sufficiently Predicts Emergent Large Vessel Occluding Strokes
The prognosis of patients with acute ischemic stroke (AIS) essentially depends on both prompt diagnosis and appropriate treatment. Endovascular stroke therapy (EST) proved to be highly efficient in the treatment of emergent large vessel occluding (ELVO) strokes in the anterior circulation. To achieve a timely diagnosis, a robust combination of few and simple signs to identify ELVOs in AIS patients applicable by paramedics in the prehospital triage is worthwhile. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 31, 2020 Category: Neurology Authors: Benedikt Johannes, Pardes Habib, Kolja Sch ürmann, Omid Nikoubashman, Martin Wiesmann, Jörg B. Schulz, Arno Reich Source Type: research

Cilostazol Versus Aspirin for Secondary Stroke Prevention: Systematic Review and Meta-Analysis
Cilostazol has promise as an alternative to aspirin for secondary stroke prevention given its vasodilatory and anti-inflammatory properties in addition to platelet aggregation inhibition. We aimed to conduct a systematic review and meta-analysis to estimate the efficacy and safety of cilostazol compared to aspirin for stroke prevention in patients with previous stroke or transient ischemic attack (TIA). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 31, 2020 Category: Neurology Authors: Michelle P. Lin, James F. Meschia, Neethu Gopal, Kevin M. Barrett, Owen A. Ross, Nil üfer Ertekin-Taner, Thomas G. Brott Source Type: research

Effective Combined Assessments of Weight Bearing Ratio and Four Square Step Test in Predicting Falls in Discharged Stroke Patients
We aimed to determine whether combined assessments of single movement tasks could predict falls in community dwelling people with stroke and it was more precision than the berg balance Scale consists of 14 movements. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 31, 2020 Category: Neurology Authors: Yoshinobu Yoshimoto, Mamoru Tanaka, Asuka Sakamoto Source Type: research

Predictive Model of Early Neurological Deterioration in Patients with Acute Ischemic Stroke: A Retrospective Cohort Study
This study aimed to develop a predictive model of early neurological deterioration (END) in patients with acute ischemic stroke (AIS). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 30, 2020 Category: Neurology Authors: Xiaohua Xie, Jingyi Xiao, Yunyun Wang, Lu Pan, Jiahui Ma, Liping Deng, Jie Yang, Lijie Ren Source Type: research

White Matter Acute Infarct Volume After Thrombectomy for Anterior Circulation Large Vessel Occlusion Stroke is Associated with Long Term Outcomes
Despite the proven efficacy of endovascular thrombectomy (EVT) for large vessel occlusion stroke, over half treated remain functionally disabled or die. Infarct topography may have implications for prognostication, patient selection, and the development of tissue-specific neuroprotective agents. We sought to quantify white matter injury in anterior circulation acute infarcts post-EVT to understand its significance and identify its determinants. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 30, 2020 Category: Neurology Authors: Robert W. Regenhardt, Mark R. Etherton, Alvin S. Das, Markus D. Schirmer, Joshua A. Hirsch, Christopher J. Stapleton, Aman B. Patel, Thabele M. Leslie-Mazwi, Natalia S. Rost Source Type: research

Malignant Left Atrial Appendage Morphology: Current Classification vs H-L System
In non-valvular atrial fibrillation (AF), more than 90% of thrombus formation occurs in the left atrial appendage (LAA).1-3 Current guidelines have established direct oral anticoagulants (DOACs) as the treatment of choice in patients with AF and high risk of stroke or transient ischemic attack (TIA), while vitamin K antagonists (VKA) can be considered in patients not suitable for DOACs.4,5 This strategy significantly reduces the risk of thromboembolism; however, there is a subset of patients that suffer recurrent embolic strokes despite appropriate anticoagulant therapy, known as malignant LAA. (Source: Journal of Stroke a...
Source: Journal of Stroke and Cerebrovascular Diseases - December 30, 2020 Category: Neurology Authors: Paloma Parra-D íaz, Luisa Salido-Tahoces, Ana Pardo-Sanz, Álvaro Beltrán-Corbellini, Fernando Rodríguez-Jorge, Juan Luis Chico-García, Sebastián García-Madrona, Consuelo Matute-Lozano, Rocío Vera-Lechuga, Antonio Cruz-Culebras, Jaime Masjuan, Alic Source Type: research

The Efficacy of Colchicine on Carotid Intima-Media Thickness: A Prospective Comparative Study
Inflammation plays an important role in the development of atherosclerotic vascular disease, which is the leading cause of morbidity and mortality in the adult population. Several clinical trials have shown that suppression of the inflammatory response can delay or decrease the atherosclerotic process. The aim of this study was to investigate carotid intima-media thickness (CIMT) between patients with chronic disease history plus gout using colchicine and patients with cardiovascular risk factors. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 30, 2020 Category: Neurology Authors: Ebru Yilmaz, Kadriye Halli Akay Source Type: research

Patient Characteristics and Outcomes Associated with Decline in Stroke Volumes during the Early COVID-19 Pandemic
Recent studies have documented a decrease in evaluations of stroke patients during the early weeks of the coronavirus disease 2019 (COVID-19) outbreak in the United States (US).1 –4 This phenomenon raises concern that delays in emergent treatment and implementation of secondary stroke prevention measures may contribute to the morbidity and mortality of the pandemic. As a second wave of COVID-19 sweeps through the country, there is an urgent need for public health communica tion that targets populations most likely to delay evaluation for stroke-like symptoms. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 25, 2020 Category: Neurology Authors: Adam N. Wallace, Kaiz S. Asif, Daniel H. Sahlein, Steven J. Warach, Timothy Malisch, E. Francis LaFranchise, Scott Geraghty, K. Derek Kreitel, Marian P. Lamonte, Jefferson T. Miley, Daniel P. Gibson, Krishna Amuluru Source Type: research

Electric Acupuncture Treatment Promotes Angiogenesis in Rats with Middle Cerebral Artery Occlusion Through EphB4/EphrinB2 Mediated Src/PI3K Signal Pathway
Cerebral infarction is one of the most common causes of disability and death worldwide. It is reported that electric acupuncture was able to improve the prognosis of cerebral infarction by promoting angiogenesis. However, the corresponding signal pathways of angiogenesis promotes by electric acupuncture treatment needs to be further explored. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 24, 2020 Category: Neurology Authors: Yuanhua Wu, Rong Hu, Xiuyan Zhong, Anbang Zhang, Bo Pang, Xiuqi Sun, Guangqi Zhu Source Type: research

Multiple Cerebrovascular Insults in Pseudoxanthoma Elasticum
Pseudoxanthoma elasticum (PXE) is a rare systemic disease with variable features, including stroke. Here, we describe a patient with PXE who developed multiple cerebrovascular pathologies decades after her diagnosis and was successfully treated with antiplatelet therapy. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 24, 2020 Category: Neurology Authors: N. Abimbola Sunmonu Tags: Case report Source Type: research

Regulatory Mechanism of MicroRNA-30b on Neonatal Hypoxic-Ischemic Encephalopathy (HIE)
This study is to investigate the role of microRNA (miR)-30b in the pathogenesis of hypoxic-ischemic encephalopathy (HIE) in neonates. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 24, 2020 Category: Neurology Authors: Weiwei Wang, Lifang Jia Source Type: research

Comparison Between Three Commonly Used Large-Bore Aspiration Catheters in Terms of Successful Recanalization and First-Passage Effect
To compare three commonly used large-bore aspiration catheters in terms of final successful recanalization rate and first-passage successful and complete recanalization rates (the so called “first-passage effect”). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 24, 2020 Category: Neurology Authors: Vittorio Semeraro, Iacopo Valente, Pietro Trombatore, Maria Porzia Ganimede, Alessandra Briatico, Carmine Di Stasi, Nicola Burdi, Giovanni Boero, Maria Pia Prontera, Prof Roberto Gandini, Sofia Vidali, Prof Marina Diomedi, Fabrizio Sallustio, Francesco D' Source Type: research

Diagnostic performances of the susceptibility vessel sign on MRI: Methodological issues
To the Editor (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 24, 2020 Category: Neurology Authors: Siamak Sabour, Hadis Ghajari Tags: Letter to the editor Source Type: research

Intravenous Thrombolysis in Acute Ischemic Stroke Patients with Unsuspected Infective Endocarditis
Infective endocarditis (IE) is considered to be an absolute contraindication for intravenous tissue plasminogen activator treatment (IVtPA) in acute ischemic stroke (AIS). However, during the hyperacute stroke evaluation, the exclusion of IE may be difficult. We sought to report the prevalence of undiagnosed IE in AIS patients who received IVtPA. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 23, 2020 Category: Neurology Authors: Mangala Gopal, Sushil Lakhani, Vivien H. Lee Tags: Case Report Source Type: research