Influence of Thrombocytopenia on the Outcome of Mechanical Thrombectomy in Patients with Acute Ischemic Stroke
Mechanical thrombectomy (MT) has become leading treatment option for acute ischemic stroke (AIS) due to large vessels occlusion (LVO). Platelet counts may affect outcome in patients with AIS or transient ischemic attack. The aim of our study was to determine the influence of thrombocytopenia on the safety and efficacy of MT in patients with AIS due to anterior circulation LVO. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 18, 2022 Category: Neurology Authors: Mirjana Ždraljević, Tatjana Pekmezović, Predrag Stanarčević, Ivan Vukašinović, Ivana Berisavac, Marko Ercegovac, Filip Vitošević, Dragoslav Nestorović, Vladimir Cvetić, Višnja Padjen, Maja Stefanović- Budimkić, Tamara Švabić Medjedović, D Source Type: research

Increased Trailing Limb Angle is Associated with Regular and Stable Trunk Movements in Patients with Hemiplegia
Physical therapists generally set gait speed (parameter to understand walking ability) as a primary goal for rehabilitation in post-stroke patients. As per reported data, 0.16  m/s is the minimal clinically important difference in gait speed among subacute stroke patients.1 Post-stroke gait speed is associated with the range of activities of daily living and quality of life, and its improvement requires intensive rehabilitation.2–4 In gait cycle, at the initial contact phase, the ankle dorsiflexion angle (ADFA) provides a stable gait performance. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 18, 2022 Category: Neurology Authors: Tsubasa Mitsutake, Hisato Nakazono, Hisayoshi Yoshizuka, Takanori Taniguchi, Maiko Sakamoto Source Type: research

Acute Myocardial Infarction after Intravenous Thrombolysis for Acute Ischemic Stroke: Case Series and Systematic Review
Intravenous thrombolysis (IV –rtPA) has been suggested as a potential cause of myocardial infarction (MI) after acute ischemic stroke (AIS), with randomized clinical trials showing a higher number of cardiac events within the thrombolysis group. We assessed the prevalence and MI mechanisms after IV–rtPA for AIS. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 18, 2022 Category: Neurology Authors: Jo ão Pedro Marto, Linda Azevedo Kauppila, Cláudia Jorge, Pedro Faustino, João Sargento-Freitas, Liliana Pereira, Sofia Galego, Rafael Dias, Pedro Castro, Teresa Pinho-e-Melo, Ana Catarina Fonseca Source Type: research

Masthead
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 18, 2022 Category: Neurology Source Type: research

Editorial Board
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 18, 2022 Category: Neurology Source Type: research

Table of Contents
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 18, 2022 Category: Neurology Source Type: research

Time metrics in acute ischemic stroke care during the second and first wave of COVID 19 Pandemic: A tertiary care center experience from South India.
This study shares our experience in stroke time metrics during the second wave of pandemic compared to the first wave. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 13, 2022 Category: Neurology Authors: Dileep Ramachandran, Praveen Panicker, P Chitra, Thomas Iype Source Type: research

Management and outcomes of COVID – 19 associated Cerebral Venous Sinus Thrombosis
Systemic hyper-coagulabilty leading to micro and macro thrombosis is a known complication of Coronavirus disease – 2019(COVID -19). The postulated mechanism appears to be the viral activation of endothelium, triggering the coagulation pathways. Thrombosis of the cerebral veins and sinuses (CVT), a potentially serious condition, has been increasingly reported with COVID – 19 infection. In this clinical stud y we attempt to describe the clinical profile, investigations and outcomes of patients with COVID- 19 associated CVT. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 9, 2022 Category: Neurology Authors: Miraclin T Angel, Sanjith Aaron, Ajith Sivadasan, Kenneth Benjamin, Vanjare Harshad, Shalini Nair, KPP Abhilash, Prabhakar AT, Vivek Mathew Source Type: research

Masthead
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 1, 2022 Category: Neurology Source Type: research

Editorial Board
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 1, 2022 Category: Neurology Source Type: research

Table of Contents
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 1, 2022 Category: Neurology Source Type: research

Response to the letter to the editor
Dear Professor Biller, (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 23, 2021 Category: Neurology Authors: How Ting Ong, Yao Hao Teo, Yao Neng Teo, Nicholas L Syn, Ching-Hui Sia Tags: Letter to the Editor Source Type: research

Managing post-stroke care during the COVID-19 pandemic at a tertiary care level hospital in Peru
Objectives: To understand the hospital-to-outpatient care transition and how the discharge process of stroke patients is managed; and to identify potential opportunities to improve these processes, while contrasting pre- and during COVID-19 experiences in Peru.Methods: A qualitative study was conducted between February and March 2021 consisting of in-depth interviews of patients with stroke, their caregivers and healthcare personnel regarding stroke care at a national tertiary referral center for stroke care in Lima, Peru. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 23, 2021 Category: Neurology Authors: Jessica Hanae Zafra-Tanaka, Jill Portocarrero, Carlos Abanto, Joseph R. Zunt, J. Jaime Miranda Source Type: research

Sodium-Glucose Co-Transporter-2 Inhibitors Decrease the Odds for Atrial Fibrillation in Subjects with Heart Failure
Ong et al. have shown in their very informative, recently published meta-analysis that sodium-glucose co-transporter-2 (SGLT-2) inhibitors result in a significant decrease in the odds for atrial fibrillation (AF) regardless of status of diabetes mellitus or cardiovascular disease at baseline.1 However, the authors failed to show that this effect is sustained in subjects with heart failure (HF).1 (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 22, 2021 Category: Neurology Authors: Dimitrios Patoulias, Christodoulos Papadopoulos, Michael Doumas Tags: Letter to the Editor Source Type: research

Preceding Head Trauma in Four Cases of Sporadic Cerebral Amyloid Angiopathy – Case Report Series
CAA is a heterogeneous group of diseases caused by A β deposition in the vascular walls, often leading to lobar ICH and cognitive impairment. Although CAA is rare in younger patients, it has been associated with specific mutations as well as with other causes. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 18, 2021 Category: Neurology Authors: Janja Pretnar Oblak, Ana Jure čič, Karin Writzl, Senta Frol Tags: Case Report Source Type: research

Somatosensory evoked potentials and transcranial color Doppler monitoring in subarachnoid hemorrhage
We describe a series of subjects, in which neurophysiological monitoring executed by simultaneous recording of somatosensory evoked potentials (SEPs) and transcranial color Doppler (TCD) was performed to reveal possible, early complications following acute SAH.Materials and methods: We described the absolute and interhemispheric values of SEPs from the upper limb and TCD examinations of the cerebral arteries in 13 subjects with acute SAH. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 16, 2021 Category: Neurology Authors: Federica Ginanneschi, Cesare Vittori, Rossana Tassi, Ilaria Severi, Federico Giuggioli, Caterina Auletta, Francesca Diana, Alessandro Rossi Source Type: research

Usefulness of Silent Magnetic Resonance Angiography in the Follow-Up of Endovascular-Treated Intracranial Aneurysm: A Prospective Study
To prospectively evaluate the clinical usefulness of Silent magnetic resonance angiography (Silent MRA) in the follow-up of endovascular-treated intracranial aneurysms by comparing it with time-of-flight magnetic resonance angiography (TOF MRA) and digital subtraction angiography (DSA). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 16, 2021 Category: Neurology Authors: Song Tan, Yuzhao Lu, Bin Li, Qin Wu, Xiaobing Zhou, Yang Wang Source Type: research

Prevalence and Predictors of Stroke in Patients with Crohn's Disease: A Nationwide Study
Mounting evidence points to the microbiome as a susceptibility factor for neurological disorders. Patients with Crohn's disease (CD) are at higher ischemic stroke (IS) risk, but no large scale epidemiologic studies have identified risk factors for stroke in this population. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 16, 2021 Category: Neurology Authors: Satvir Saggi, Alain Lekoubou, Bruce Ovbiagele Source Type: research

Impact of Arrhythmia in Hospital Mortality in Acute Ischemic Stroke Patients: A Retrospective Cohort Study in Northern Mexico
Stroke remains one of the leading causes of death globally. 1 In Mexico, it represents the 6th cause of death2 and contributes with 688.19 DALYs per 100,000 people,3 constituting a major cause of burden of disease in the country. Heart rhythm dysfunctions following acute ischemic strokes (AIS) have been previously reported,4 –9 and it is expected that 25-30% of patients will be diagnosed with any type of arrhythmia after stroke.6,9 Kallmünze et al. reported the incidence of several post-stroke arrhythmias, such as atrial fibrillation (AF), focal atrial tachycardia, undetermined supraventricular tachycardia,...
Source: Journal of Stroke and Cerebrovascular Diseases - December 16, 2021 Category: Neurology Authors: J. De la Fuente-Mart ínez, A. Infante-Valenzuela, D. Martínez-Roque, M. Cruz-Moreno, F. Góngora-Rivera Source Type: research

Prospective Interventions to Reduce Stroke Care Variation in a Hub-and-Spokes System
Care variation reduction (CVR) is a central objective of quality management to decrease wasted spending. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 15, 2021 Category: Neurology Authors: Rohini Bhole, Angela M. Sales, Anupam Lahiri, Lauren Knight, Robin J. Womeodu, Arthur M. Townsend, Andrei V. Alexandrov Source Type: research

Acute Treatment of Isolated Posterior Cerebral Artery Occlusion: Single Center Experience
Randomized trials for mechanical thrombectomy (MT) excluded patients with ischemic strokes due to isolated posterior cerebral artery occlusion (IPCAO), and there is no evidence for best acute treatment strategy in these patients. We aimed to assess the effectiveness and safety of MT in acute IPCAO. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 12, 2021 Category: Neurology Authors: Bruno Cunha, Mariana Baptista, Jaime Pamplona, Rui Carvalho, Catarina Perry da C âmara, Marta Alves, Ana Luísa Papoila, Ana Paiva Nunes, João Reis, Isabel Fragata Source Type: research

Machine Learning Models Prognosticate Functional Outcomes Better than Clinical Scores in Spontaneous Intracerebral Haemorrhage
Spontaneous intracerebral haemorrhage (SICH) was associated with an overall incidence of 24.6 per 100,000 person-years worldwide and was most common in Asians, with an incidence of 51.8 per 100,000 person-years.1 SICH is a major cause of mortality and morbidity, with a case fatality of 40.4% at one month, one-year mortality rate of 54.0% and only 12 to 39% of patients leading an independent life on follow up.1,2 Current management for SICH remains supportive, and includes outcome prediction and rehabilitation. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 10, 2021 Category: Neurology Authors: Mervyn Jun Rui Lim, Raphael Hao Chong Quek, Kai Jie Ng, Ne-Hooi Will Loh, Sein Lwin, Kejia Teo, Vincent Diong Weng Nga, Tseng Tsai Yeo, Mehul Motani Source Type: research

Plasma Pro-Enkephalin A and Ischemic Stroke Risk: The Reasons for Geographic and Racial Differences in Stroke Cohort
Ischemic stroke is a leading cause of death and disability.1 Stroke care has seen vast improvements in diagnosis and treatment in recent years, yet efforts to identify novel biomarkers of increased risk for future stroke have yielded few results.2,3 The early detection of individuals at high stroke risk is important in implementing preventative measures.4 (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 10, 2021 Category: Neurology Authors: Samuel AP Short, Katherine Wilkinson, D Leann Long, Suzanne Judd, Janin Schulte, Brett M Kissela, George Howard, Mary Cushman Source Type: research

Red Cell Distribution Width as a Predictor of One-Year Prognosis and Mortality of Endovascular Therapy for Acute Anterior Circulation Ischemic Stroke
To investigate if Red cell distribution width (RDW) can predict long-term prognosis in patients with acute ischemic stroke (AIS) receiving endovascular therapy (EVT). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 10, 2021 Category: Neurology Authors: Zhengyang Wang, Yin Liu Source Type: research

Brain Abnormalities in Pontine Infarction: A Longitudinal Diffusion Tensor Imaging and Functional Magnetic Resonance Imaging study
Stroke refers to poor blood flow to the brain that leads to cell death and is one of the major threats to human life and health.1 Eighty percent of stroke are ischemic stroke.2 Among them, approximately 3% of ischemic strokes are solitary pontine infarctions.3 Pontine infarction is acute, the clinical manifestations are complicated, and the clinical manifestations vary greatly among individuals. Most surviving patients may have different degrees of motor dysfunction. How to make a reasonable and accurate assessment of the prognosis of patients with pontine infarction and carry out a series of rehabilitation treatments base...
Source: Journal of Stroke and Cerebrovascular Diseases - December 5, 2021 Category: Neurology Authors: Jing Li, Dong-Dong Rong, Yi Shan, Miao Zhang, Cheng Zhao, Jie Lu Source Type: research

Stroke Risk Due to Smoking Characterized by Sex Differences in Japan: The Jichi Medical School Cohort Study
Globally, smoking is a serious health problem, with detrimental effects caused by exposure to smoke. Although smoking is an avoidable risk factor, it accounts for approximately 8 million deaths annually,1 and can reduce life expectancy by 10 years.2 In Japan, the average smoking prevalence has been declining year by year, with a male smoking prevalence of 27.1% and a female smoking prevalence of 7.6% in 2019.3 However, smoking prevalence remains high in middle age, and smoking cessation is a goal that has not yet been achieved. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 4, 2021 Category: Neurology Authors: Fumitaka Sato, Yosikazu Nakamura, Kazunori Kayaba, Shizukiyo Ishikawa Source Type: research

Depression and Anxiety after Stroke in Young Adult Filipinos
Anxiety and depression are important psychiatric conditions to recognize after stroke.1 Poststroke depression (PSD) has been reported in around one third of stroke patients while poststroke anxiety affects a quarter of stroke patients.2 Depression and anxiety may also co-exist and persist in individuals long after a stroke.3 These complications adversely impact stroke outcome.4,5 Apart from restrictions in social function, they are associated with poorer quality of life, diminished functionality and increased risks of mortality. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 4, 2021 Category: Neurology Authors: Katrina Hannah D. Ignacio, Jose Danilo B. Diestro, Jose Miguel M. Medrano, Sitti Khadija U. Salabi, Alvin J. Logronio, Sedric John V. Factor, Sharon D. Ignacio, Jose Leonard R. Pascual V, Maria Carissa C. Pineda-Franks Source Type: research

Effects of dual transcranial direct current stimulation and modified constraint induced movement therapy to improve upper-limb function after stroke: A double-blinded, pilot randomized controlled trial
We thank you for providing an opportunity to write letter to the editor to the article by Sun Ho Kim.1 We read the article with much interest, and they have explained the effects of Dual tDCS and mCIMT to Improve Upper-Limb Function after Stroke. Regarding the article we would like to elaborate few comments related to methodology and results which would be matter of great concern. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 4, 2021 Category: Neurology Authors: Rittu Sharma, Vencita Priyanka Aranha, Akanksha Saxena, Asir John Samuel Tags: Letter to the editor Source Type: research

Using the Barthel Index and modified Rankin Scale as Outcome Measures for Stroke Rehabilitation Trials; A Comparison of Minimum Sample Size Requirements
Underpowered trials risk inaccurate results. Recruitment to stroke rehabilitation randomised controlled trials (RCTs) is often a challenge. Statistical simulations offer an important opportunity to explore the adequacy of sample sizes in the context of specific outcome measures. We aimed to examine and compare the adequacy of stroke rehabilitation RCT sample sizes using the Barthel Index (BI) or modified Rankin Scale (mRS) as primary outcomes. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 3, 2021 Category: Neurology Authors: Kris McGill, Catherine Sackley, Jon Godwin, David Gavaghan, Myzoon Ali, Belen Rubio Ballester, Marian C Brady, VISTA-Rehabilitation collaborators Source Type: research

Ischemic Stroke and Asymptomatic Pulmonary Opacities
Pulmonary opacities are described in many chest radiograph reports in stroke patients and are often asymptomatic. The aim of this study is to investigate the clinical features associated with asymptomatic pulmonary opacities (APO) and evaluate APO prognostic value in ischemic stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 3, 2021 Category: Neurology Authors: Carmelo Tiberio Curr ò, Masina Cotroneo, Antonio Ciacciarelli, Cristina Dell'Aera, Francesco Grillo, Paolino La Spina, Maria Carolina Fazio, Angelina Laganà, Jolanda De Caro, Giuseppe Trimarchi, Antonio Toscano, Rosa Fortunata Musolino, Carmela Casella Source Type: research

Denial of Cerebrovascular Events in a National Clinical Quality Registry for Stroke: A Retrospective Cohort Study
To investigate cerebrovascular event (CVE) denials reported by registered patients to the Australian Stroke Clinical Registry, and to examine the factors associated with CVE denial. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 2, 2021 Category: Neurology Authors: Karen M. Barclay, Monique F. Kilkenny, Sibilah J. Breen, Olivia F. Ryan, Kathleen L. Bagot, Natasha A. Lannin, Vincent Thijs, Dominique A. Cadilhac, AuSCR Consortium Source Type: research

Height is Inversely Associated with Biomarkers of Intracranial Atherosclerotic Disease in Older Adults of Amerindian Ancestry: Exploring the Obesity Paradox
Various anthropometric measurements have been inversely associated with atherosclerosis, giving rise to the concept of an “obesity paradox” However, inconsistent study results make it difficult to determine the best anthropometric measurement with which to assess such inverse relationship. Height has been inversely associated with atherosclerosis and it is unlikely to be associated with unexpected biases. In this s tudy, we aimed to assess the association between height and other anthropometric measurements and intracranial atherosclerotic disease (ICAD). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 2, 2021 Category: Neurology Authors: Oscar H. Del Brutto, Robertino M. Mera, Bettsy Y. Recalde, Pedro P érez, José Ortega-Tola, Denisse A. Rumbea, Mark J. Sedler Source Type: research

Acute Hyperglycemia Exacerbates Hemorrhagic Transformation after Embolic Stroke and Reperfusion with tPA: A Possible Role of TXNIP-NLRP3 Inflammasome
Acute hyperglycemia (HG) exacerbates reperfusion injury after stroke. Our recent studies showed that acute HG upregulates thioredoxin-interacting protein (TXNIP) expression, which in turn induces inflammation and neurovascular damage in a suture model of ischemic stroke. The aim of the present study was to investigate the effect of acute HG on TXNIP-associated neurovascular damage, in a more clinically relevant murine model of embolic stroke and intravenous tissue plasminogen activator (IV-tPA) reperfusion. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 27, 2021 Category: Neurology Authors: Mohd. Salman, Saifudeen Ismael, Li Lexiao, Heba A. Ahmed, Michelle A. Puchowicz, Tauheed Ishrat Source Type: research

Effectiveness of Public Education Campaigns for Stroke Symptom Recognition and Response in Non-Elderly Adults: A Systematic Review and Meta-Analysis
This study investigated the effectiveness of stroke campaigns in improving stroke symptom recognition and intention to call emergency medical services in adults aged (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 26, 2021 Category: Neurology Authors: Jiayi Tan, Sheena Ramazanu, Sok Ying Liaw, Wei Ling Chua Tags: Review Article Source Type: research

Trends in Diet Counseling Among Stroke Versus Non-Stroke Patients: Evidence from the NAMCS, 2011 –2016
Dietary modifications in post-stroke patients facilitated by diet counseling improves post-stroke recovery and stroke recurrence. The extent to which clinicians provide dietary counseling for these patients is unknown. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 26, 2021 Category: Neurology Authors: Nikhila Gandrakota, Vishal B Patel, Miranda Moore, Karima Benameur, Megha K Shah Source Type: research

Posterior Communicating Artery Hypoplasia: A Risk Factor for Vertebral Artery Dissection Causing Subarachnoid Hemorrhage
Subarachnoid hemorrhage due to vertebral artery dissection is often fatal; however, its anatomical predictors remain unclear. We conducted a retrospective hospital-based case-control study to evaluate whether variations in the posterior communicating artery are associated with the risk of vertebral artery dissection with subarachnoid hemorrhage. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 26, 2021 Category: Neurology Authors: Kenichi Ariyada, Keita Shibahashi, Naoshi Fujika, Yuya Sakakura, Kazuo Hanakawa, Masahiko Murao Source Type: research

The Reliability and Validity of Post Stroke Depression Scale in Different Type of Post Stroke Depression Patients
Stroke is the second leading cause of death around the world, and approximately a third of all stroke survivors were have different degree of depression at any time after stroke.1 The repercussions of post-stroke depression (PSD) might cause extend psychological wellbeing, worsen rehabilitation outcomes, even lead to post-stroke mortality.2,3 Therefore, the early detection of PSD is essential to promote the prognosis and avoid unfortunate incidents. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 25, 2021 Category: Neurology Authors: Yingying Yue, Rui Liu, Jiu Chen, Yin Cao, Yanfeng Wu, Shining Zhang, Huajie Li, Jijun Zhu, Aiqin Wu, Yonggui Yuan Source Type: research

RIPK3-Dependent Necroptosis Activates MCP-1-Mediated Inflammation in Mice after Intracerebral Hemorrhage
Intracerebral hemorrhage (ICH) is one of the common subtype of stroke, accounting for 10% –15% of all strokes.1 ICH causes severe neurological deficits and high mortality, but effective treatment is still lacking.2 Mechanical compression from hematoma and pathophysiological damage result in cell death comprising of apoptosis, necrosis and necroptosis.3 When the cell undergoes death, it releases a large number of signal molecules, which activates the immune system and produces an inflammatory response. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 25, 2021 Category: Neurology Authors: Simei Huang, Wenjie Hu, Dongmei Rao, Xiaodong Wu, Qingqing Bai, Jingye Wang, Zhaohu Chu, Yang Xu Source Type: research

Fulminant reversible cerebral vasoconstriction syndrome in breakthrough COVID 19 infection
We report a case of fulminant reversible cerebrovascular constriction syndrome (RCVS) in a patient with breakthrough COVID 19 infection who was fully vaccinated. A 64 year old lady, fully vaccinated 2 months back, presented with headache, drowsiness, partial seizures, visual impairment and quadriplegia. Her nasopharyngeal swab was tested positive for SARS COV2 on real time PCR assay. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 25, 2021 Category: Neurology Authors: Somdattaa Ray, Vikram V Kamath, Arjun Raju P, Rajesh K.N, Shalini N Source Type: research

Self-Reported Race as a Social Determinant of Stroke Risk in Observational Versus Clinical Trial Datasets
Self-reported Black (SRB) Americans are approximately twice as likely to have a stroke as self-reported White (SRW) Americans. While social determinants of health and vascular risk factors account for some of the disparity, half the increased risk remains unexplained and may be related to unmeasured real-world factors of the racialized experience. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 24, 2021 Category: Neurology Authors: Alison L. Herman, Kevin N. Sheth, Olajide A. Williams, Karen C. Johnston, Shyam Prabhakaran, Adam de Havenon Tags: Short Communication Source Type: research

Dl-3-N-Butylphthalide Attenuates Hypoxic Injury of Neural Stem Cells by Increasing Hypoxia-Inducible Factor-1alpha
To assess the potential effect of dl-3-N-butylphthalide (dl-NBP) for the proliferation and differentiation of neural stem cells (NSCs) against hypoxia and the underlying mechanism. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 24, 2021 Category: Neurology Authors: Chaoqun Lin, Shiying Huang, Jianfeng Zhang, Huaitao Yuan, Tuchao Yao, Lukui Chen Source Type: research

The Efficacy of Group Acceptance and Commitment Therapy for Preventing Post-Stroke Depression: A Randomized Controlled Trial
In this study, group Acceptance and Commitment Therapy (G-ACT) was performed in acute stroke patients to see if it can effectively relieve depressive symptoms and improve neurological function. The efficacy was also evaluated in stroke patients of different severity. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 24, 2021 Category: Neurology Authors: Yunlian Niu, Shiying Sheng, Yan Chen, Jian Ding, Huajie Li, Shujing Shi, Jian Wu, Dan Ye Source Type: research

Stroke Risk in Patients with Suspected Transient Ischemic Attacks with Focal and Nonfocal Symptoms: A Prospective Study
The aim was to investigate triage methods for suspected transient ischemic attacks (TIAs) with focal or nonfocal symptoms. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 23, 2021 Category: Neurology Authors: Hiroshi Shima, Hiroki Taguchi, Yoshikazu Niwa, Kuniaki Bandoh, Yukoh Watanabe, Kohei Yamashita, Kenji Shimazaki, Hideki Koyasu, Yasuhiro Hasegawa, COMBAT-TIA Study Investigators Source Type: research

Phase Angle as an Indicator of Baseline Nutritional Status and Sarcopenia in Acute Stroke
The outcomes of stroke patients are related to sex, neurological severity, activities of daily living (ADL) before stroke onset, nutritional status, and presence of sarcopenia.1 –5 Stroke patients with malnutrition or sarcopenia could improve their outcomes by improving malnutrition and sarcopenia with exercise therapy and nutritional support.6,7 Therefore, the nutritional status and the presence of sarcopenia in stroke patients need to be evaluated early after stroke ons et in order to improve outcomes with timely and appropriate interventions. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 23, 2021 Category: Neurology Authors: Yoichi Sato, Yoshihiro Yoshimura, Takafumi Abe Source Type: research

Family History is Related to High Risk of Recurrent Events after Ischemic Stroke or Transient Ischemic Attack
Prior data suggest paternal or sibling stroke was associated with increased risk of offspring stroke. Whether family history of cardiovascular disease (FHc) predicts risk of stroke recurrence remains unclear, we aim to determine this issue on patients with ischemic stroke (IS) or transient ischemic attack (TIA). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 22, 2021 Category: Neurology Authors: Xing Zhang, Si Cheng, Hongqiu Gu, Yingyu Jiang, Hao Li, Zixiao Li, Xia Meng, Yongjun Wang Source Type: research

Balloon-Assisted Roadmap Technique to Enable Flow Diversion of a High-Flow Direct Carotid-Cavernous Fistula
Flow diversion as a first-line treatment for direct CCF has recently been described, usually with adjunct coiling. Theoretical and technical advantages of flow diversion include its ability to better protect the carotid and to facilitate safer thrombosis of the cavernous sinus with lower risk of resultant cranial nerve deficits. However, cases in which there is absence of antegrade internal carotid artery (ICA) filling distal to the fistula present a unique challenge for safe deployment of flow diverters. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 22, 2021 Category: Neurology Authors: Francis J. Jareczek, Varun Padmanaban, Ephraim W. Church, Scott D. Simon, Kevin M. Cockroft, D. Andrew Wilkinson Tags: Case Report Source Type: research

Perfusion Imaging Collateral Scores Predict Infarct Growth in Non-Reperfused DEFUSE 3 Patients
This study evaluated the associations of perfusion imaging collateral profiles with radiographic and clinical outcome in late presenting, non-reperfused patients in the DEFUSE 3 clinical trial. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 22, 2021 Category: Neurology Authors: Adam MacLellan, Michael Mlynash, Stephanie Kemp, Santiago Ortega-Gutierrez, Jeremy J. Heit, Michael P. Marks, Maarten G. Lansberg, Gregory W. Albers, DEFUSE 3 Investigators Source Type: research

Prevalence and Risk Factors of Silent Cerebral Microbleeds in Patients with Coronary Artery Disease
Coronary artery disease (CAD) and stroke are the two most common causes of death and disability worldwide, notably affecting aging populations.1 These cardiovascular disorders lead to impaired activity daily life and increase the risk of dementia.2,3 Brain magnetic resonance imaging (MRI) has excellent sensitivity in detecting ischemic lesions and can reveal asymptomatic, small, cerebral hemorrhages that are called cerebral microbleeds (CMBs).4 A systematic review reported that microbleeds were present on the MRIs of 5% of healthy adults, 34% of patients with ischemic stroke, and 60% of patients with nontraumatic intracere...
Source: Journal of Stroke and Cerebrovascular Diseases - November 22, 2021 Category: Neurology Authors: Ryo Yokoyama, Yumiko Kanzaki, Tomohiko Watanabe, Kenichiro Yamamura, Tsuyoshi Komori, Yoshihiro Takeda, Osamu Nakajima, Koichi Sohmiya, Masaaki Hoshiga Source Type: research

Cerebrovascular involvement in mucormycosis in COVID-19 pandemic
We describe clinico-radiological manifestations of cerebrovascular complications observed in CAM. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 21, 2021 Category: Neurology Authors: Rahul Kulkarni, Shripad S Pujari, Dulari Gupta, Pawn Ojha, Megha Dhamne, Vyankatesh Bolegave, Pramod Dhonde, Anand Soni, Sikandar Adwani, Anand Diwan, Dhananjay Duberkar, Dhruv Batra, Rushikesh Deshpande, Kaustubh Aurangabadkar, Nilesh Palasdeokar Source Type: research

Repeated cardioembolic stroke after COVID-19 mRNA vaccination: A case report
: There have been no reports suggesting a relationship between the COVID-19 mRNA vaccines that encodes the spike glycoprotein of SARS-CoV-2 and cerebrovascular disease. A case of repeated cardioembolic stroke after vaccination with the BNT162b2 (Pfizer) COVID-19 mRNA vaccine is presented. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 21, 2021 Category: Neurology Authors: Kentaro Yoshida, Kenichiro Tanaka, Yutaka Suto, Hiroki Fukuda Tags: Case Report Source Type: research