What is the Price of the Potential for a Meaningful Recovery following Intracerebral Hemorrhage?
In this issue of the Journal of Stroke and Cerebrovascular Diseases, Vardanyan and colleagues report on the cost-utility of minimally invasive surgery (MIS) with thrombolysis for spontaneous intracerebral hemorrhage (ICH) from the perspective of the United Kingdom (UK) National Health Service (NHS)1 using data from the Minimally Invasive Surgery Plus Alteplase in Intracerebral Hemorrhage Evacuation (MISTIE III) trial2 and the UK Sentinel Stroke National Audit Programme (SSNAP).3 The economic evaluation revealed that the incremental cost-effectiveness ratio for MIS with thrombolysis fell significantly above the UK's Nationa...
Source: Journal of Stroke and Cerebrovascular Diseases - July 27, 2021 Category: Neurology Authors: Lourdes R. Carhuapoma, Avni Kapadia, Henry A. Glick, Daniel F. Hanley Source Type: research

Brain & Kidney 2020: Introduction to Special Issue
On May 8, 2020, a first-of-its-kind symposium was held, “Brain& Kidney 2020 ”. The virtual event was jointly sponsored by UC Irvine School of Medicine and the Veterans Health Administration, Department of Veterans Affairs. It proved to be a smashing success, with approximately 1200 registrants attending from five continents. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 19, 2021 Category: Neurology Authors: Mark Fisher, Wei Ling Lau, Bruce Coull Source Type: research

Response by Mac Grory et  al. to Letter regarding “Structural and Functional Imaging of the Retina in Central Retinal Artery Occlusion – Current Approaches and Future Directions”
We wish to thank Drs. Tuuminen, Achiron and Kanclerz for the interest in our paper and for the opportunity to address several entrenched misconceptions about the treatment of central retinal artery occlusion (CRAO). In 2015, Schrag et  al.1 published a subject level meta-analysis concerning visual outcomes in patients with CRAO who were untreated, treated with thrombolysis or treated with a variety of conservative therapies (anterior chamber paracentesis, ocular massage and/or hemodilution). An important innovation in this work was the use of a simple, reproducible definition of visual recovery as the attainment of a ...
Source: Journal of Stroke and Cerebrovascular Diseases - July 15, 2021 Category: Neurology Authors: Brian Mac Grory, Matthew Schrag, Sven Poli, Chantal Boisvert, Val érie Biousse, Wuwei Feng Source Type: research

Controversies on the Recommended Treatment for Central Retinal Artery Occlusion
In a recent article, Mac Grory et al.1 described the structural and functional retinal imaging modalities in central retinal artery occlusion (CRAO). They have also suggested that thrombolysis is emerging as a compelling therapeutic approach for CRAO treatment, and should be administered shortly after the onset of visual loss to induce recanalisation of the occluded retinal arteries and reperfusion of the ischemic retina before retinal cell death. Importantly, there is considerable variability in CRAO management patterns among practitioners, institutions, and subspecialty groups. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 14, 2021 Category: Neurology Authors: Raimo Tuuminen, Asaf Achiron, Piotr Kanclerz Tags: Letter to the Editor Source Type: research

Masthead
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 11, 2021 Category: Neurology Source Type: research

Editorial Board
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 11, 2021 Category: Neurology Source Type: research

Table of Contents
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 11, 2021 Category: Neurology Source Type: research

Retraction notice to "Impact of the COVID-19 Pandemic on Stroke Epidemiology and Clinical Stroke Practice in the US" [Journal of Stroke and Cerebrovascular Diseases, Vol. 30, No. 4 (April), 2021: 105639]
This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 11, 2021 Category: Neurology Authors: Daniel Friedlich, Tali Newman, Stephanie Bricker Tags: Retraction notice Source Type: research

Erratum to ’Recovery of Hypoxic Regions in a Rat Model of Microembolism’ [Journal of Stroke and Cerebrovascular Diseases, Vol. 30, No. 6 (June), 2021: 105739]
The publisher regrets that in the abstract, the RESULTS section was omitted from the published version. The following information has been added to the abstract: (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 8, 2021 Category: Neurology Authors: Theodosia Georgakopoulou, Anne-Eva van der Wijk, Erik N.T.P. Bakker, Ed vanBavel, INSIST investigators Tags: Erratum Source Type: research

Risk Factors for Stroke in HIV-Positive and-Negative Patients in Pretoria, South Africa
This study compares risk factors and types of stroke between HIV-positive and –negative patients in South Africa. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - June 24, 2021 Category: Neurology Authors: Louis Kroon, Daniel G. van Zyl, Clara M. Schutte, Christine Smit, Juliane Hiesgen Source Type: research

Neuroimaging Considerations in Patients with Chronic Kidney Disease
Chronic Kidney Disease is a common medical condition that frequently overlaps with neurologic disease. Neuroimaging can be a useful tool to aid in the diagnoses of neurologic illness, including those that result from renal impairment. Some neuroimaging studies also have the potential to lead to adverse effects on the kidneys necessitating a thoughtful approach to selection of imaging modalities. In particular, multimodal imaging is becoming increasingly common in patients presenting with symptoms of acute stroke, a population that may be at higher risk for renal complications. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - June 24, 2021 Category: Neurology Authors: Michael J. Lyerly, Daniel Chow Source Type: research

Ultra-Early Induction of General Anesthesia for Reducing Rebleeding Rates in Patients with Aneurysmal Subarachnoid Hemorrhage
Rebleeding of aneurysmal subarachnoid hemorrhage (aSAH) is one of the significant risk factors for poor clinical outcome. The rebleeding risk is the highest during the acute phase with an approximate rebleeding rate of 9-17% within the first 24 h. Theoretically, general anesthesia can stabilize a patient's vital signs; however, its effectiveness as initial management for preventing post-aSAH rebleeding remains unclear. The purpose of this study was to determine the feasibility and safety of ultra-early general anesthesia induction for reducing the rebleeding rates among patients with aSAH. (Source: Journal of Stroke and Ce...
Source: Journal of Stroke and Cerebrovascular Diseases - June 22, 2021 Category: Neurology Authors: Junya Kaneko, Takashi Tagami, Chie Tanaka, Kentaro Kuwamoto, Shin Sato, Ami Shibata, Saori Kudo, Akiko Kitahashi, Masamune Kuno, Shoji Yokobori, Kyoko Unemoto Source Type: research

A Cost Utility Analysis of Minimally Invasive Surgery with Thrombolysis Compared to Standard Medical Treatment in Spontaneous Intracerebral Haemorrhagic Stroke
Standard medical management of spontaneous intracerebral haemorrhage (ICH) and surgical hematoma evacuation starkly differ, and whilst landmark randomised control trials report no clinical benefit of early surgical evacuation compared with medical treatment in supratentorial ICH, minimally invasive surgery (MIS) with thrombolysis has been neglected within these studies. However, recent technological advancements in MIS have renewed interest in the surgical treatment of ICH. Several economic evaluations have focused on the benefits of MIS in ischaemic stroke management, but no economic evaluations have yet been performed co...
Source: Journal of Stroke and Cerebrovascular Diseases - June 22, 2021 Category: Neurology Authors: Robert Vardanyan, Arwa Hagana, Haseeb Iqbal, Arian Arjomandi Rad, Mohammad Mahmud, Kajal Ruparell, Nuha Rabee, Javad Khan, William Poole, Raad A Shakir Source Type: research

Early Cerebrovascular Ultrasonography as a Predictor of Hemorrhagic Transformation After Thrombectomy
To determine the predictive value of early transcranial color-coded sonography (TCCS) for intracranial hemorrhage (ICH) in patients with large artery occlusion (LAO) stroke of carotid circulation, who were submitted to endovascular therapy (EVT) with successful reperfusion. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - June 19, 2021 Category: Neurology Authors: L. Cruz, A. Silva, J. Lopes, D. Damas, J. Louren ço, A. Costa, F. Silva, J. Sousa, O. Galego, C. Nunes, R. Veiga, C. Machado, B. Rodrigues, C. Cecilia, L. Almendra, A. Bras, G. Santo, E. Machado, J. Sargento-Freitas Source Type: research

Cost Burden and Cost-Effective Analysis of the Nationwide Implementation of the Quality in Acute Stroke Care Protocol in Australia
Stroke is the third global leading cause of death and disability.1,2 In Australia, stroke accounts for 3% of the total burden of disease and 5% of all deaths, with 36,700 incident strokes annually.3 Healthcare expenditure for stroke in Australia in 2017 was AUD 663 million.4 (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - June 19, 2021 Category: Neurology Authors: Clara Marquina, Zanfina Ademi, Ella Zomer, Richard Ofori-Asenso, Rhiannon Tate, Danny Liew Source Type: research

Atrial Cardiopathy Biomarkers and MRI-Based Infarct Patterns in Patients with Embolic Strokes of Undetermined Source
Embolic stroke of undetermined source (ESUS) refers to non-lacunar ischemic strokes without a well-recognized cardioembolic source or stenosis of a large vessel supplying the infarcted terroritory1 and accounts for 9-25% of all ischemic stroke cases.2 Although ESUS can be related to various potential sources of thromboembolism, the most prevalent embolic source seems to be the heart. Thus, ESUS may be more responsive to anticoagulant therapy than antiplatelet therapy.1 However, recent clinical trials have failed to confirm that oral anticoagulation lowers the risk of stroke recurrence, relative to aspirin. (Source: Journal...
Source: Journal of Stroke and Cerebrovascular Diseases - June 19, 2021 Category: Neurology Authors: Yoon-Kyung Lee, Byung-Cheol Gwak, Byeol-A Yoon, Dae-Hyun Kim, Jae-Kwan Cha Source Type: research

Agreement and Accuracy of Ischemic Core Volume Evaluated by Three CT Perfusion Software Packages in Acute Ischemic Stroke
To compare the ischemic core volume estimated by CT Perfusion 4D and Vue PACS with that estimated by RAPID software in acute ischemic stroke (AIS). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - June 18, 2021 Category: Neurology Authors: Qin Chen Liu, Zhen Yu Jia, Lin Bo Zhao, Yue Zhou Cao, Gao Ma, Hai Bin Shi, Sheng Liu Source Type: research

Cost-Effectiveness Analysis of Percutaneous Patent Foramen Ovale Closure Preventing Secondary Ischemic Stroke in Japan
Cryptogenic ischemic stroke is a type of ischemic stroke for which the mechanism of onset and etiology cannot be explained or specified by any known mechanisms/factors. The possible involvement of patent foramen ovale (PFO) in the etiology of cryptogenic ischemic stroke has been reported.1 It was previously reported that occult atrial fibrillation and PFO were embolic sources that caused cryptogenic ischemic stroke.2 PFO is an opening formed during the course of fetal atrial septum development. Usually, it closes spontaneously after birth; however, PFO remains patent after maturation to adulthood. (Source: Journal of Strok...
Source: Journal of Stroke and Cerebrovascular Diseases - June 18, 2021 Category: Neurology Authors: Sachie Inoue, Ataru Igarashi, Yasuyuki Iguchi, Teiji Akagi Source Type: research

Non-Adherence to Antihypertensive Guidelines in Patients with Asymptomatic Carotid Stenosis
Hypertension and carotid stenosis are both risk factors for stroke, but the presence of carotid stenosis might dampen enthusiasm for tight control of hypertension because of concerns for hypoperfusion. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - June 18, 2021 Category: Neurology Authors: William Haley, Fayaz Shawl, W. Charles Sternbergh, Tanya N. Turan, Kevin Barrett, Jenifer Voeks, Thomas Brott, James F. Meschia Source Type: research

Spontaneous Subarachnoid Haemorrhage in Spinal Hemangioblastoma: Illustrative Case and Discussion of a Pathophysiological Hypothesis
Spontaneous non-aneurysmal subarachnoid haemorrhage (naSAH) is an unusual finding that could be burdened by significant mortality and morbidity rates. Rare pathologies and delayed diagnosis could be advocated as responsible of unfavourable outcomes. Herein, we describe an exceedingly rare giant lumbar spinal hemangioblastoma (80  × 23 mm) presenting as an intracranial naSAH. Based on our radiological and clinical findings a pathophysiological hypothesis linking intracranial naSAH to venous hypertension was discussed for the first time even among lumbar spinal tumors. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - June 18, 2021 Category: Neurology Authors: Giacomo Bertolini, Alessia Fratianni, Alberto Luca Messina, Enrico Epifani, Matteo Fantoni, Pellegrino Crafa, Diego Mazzatenta, Roberto Menozzi, Ermanno Giombelli Source Type: research

Bone Marrow Mononuclear Cells Transplantation and Training Increased Transplantation of Energy Source Transporters in Chronic Stroke
Bone marrow mononuclear cells (BM-MNC) show a significant therapeutic effect in combination with training even in the chronic phase of stroke. However, the mechanism of this combination therapy has not been investigated. Here, we examined its effects on brain metabolism in chronic stroke mice. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - June 18, 2021 Category: Neurology Authors: Yuko Ogawa, Orie Saino, Yuka Okinaka, Akie Kikuchi-Taura, Yukiko Takeuchi, Akihiko Taguchi Source Type: research

Recurrent Ischemic Stroke – A Systematic Review and Meta-Analysis
Recurrent ischemic stroke (IS) remains a challenge even with improved neuroimaging, acute stroke management, and disseminated use of secondary prevention.1 The consequences of recurrent IS are more extensive cerebrovascular impairments resulting in additional physical and cognitive disability, and significant social impact. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - June 18, 2021 Category: Neurology Authors: Mia Kolmos, Laura Christoffersen, Christina Kruuse Tags: Review Article Source Type: research

Impact of COVID-19 pandemic on stroke severity and mortality in the south-east of Santiago, Chile
Background and purpose: Chile has been one of the most affected countries by the COVID-19 pandemic, with one of the highest case rates per population. This has affected the epidemiological behaviour of various pathologies. We analyze the impact of the pandemic on the number of admissions due to stroke, its severity and mortality in Santiago, Chile.Methods: a multicenter observational study based on the records of the 3 hospitals of the South East health service in Santiago, Chile. We recorded the number of patients admitted for ischemic stroke between 01 January 2020 and 30 June 2020. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - June 18, 2021 Category: Neurology Authors: Andres Silva-Pozo, Jose Vallejos, Juan Almeida, Mariano Martoni, Reinaldo Uribe-San Martin, Mar ía Miranda, Pablo Diaz, Dominga García, Victor Navía Source Type: research

Prognostic Factors for Long-Term Recovery of Homonymous Visual Field Defects After Posterior Circulation Ischemic Stroke
This study examines the frequency of long-term recovery from HVFDs in patients with posterior circulation infarction (POCI) and evaluates whether demographic or clinical characteristics are prognostic factors of perimetric recovery. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - June 17, 2021 Category: Neurology Authors: C árdenas-Belaunzarán Jorge, Cano-Nigenda Vanessa, Barboza Miguel A, González-Olhovich Irene, Arauz Antonio Source Type: research

Cerebral Venous Sinus Thrombosis is not Significantly Linked to COVID-19 Vaccines or Non-COVID Vaccines in a Large Multi-State Health System
To assess the association of COVID-19 vaccines and non-COVID-19 vaccines with cerebral venous sinus thrombosis (CVST). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - June 16, 2021 Category: Neurology Authors: Colin Pawlowski, John Rinc ón-Hekking, Samir Awasthi, Viral Pandey, Patrick Lenehan, AJ Venkatakrishnan, Sairam Bade, John C. O'Horo, Abinash Virk, Melanie D. Swift, Amy W. Williams, Gregory J. Gores, Andrew D. Badley, John Halamka, Venky Soundararajan Source Type: research

Discovery of Anti-SS-A Antibodies during Stroke Investigations in Young Adults: What Impact?
Approximately 10 to 14% of ischemic strokes (IS) occur in young adults.1,2 It is a relatively rare event but several international studies have recently demonstrated a rising incidence in this population.3 –6 In the United States,4 the rate of strokes in the 35- to 39-year age group increased from 9.5 strokes per 100,000 person-years in 1995–1999 to 23.6 strokes per 100,000 person-years in 2010–2014 (risk ratio 2.47; 95% CI, 2.07–2.96 [p  (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - June 15, 2021 Category: Neurology Authors: Soledad Henriquez, Nicolas Legris, Pascale Chr étien, Salima Hacein-Bey-Abina, Julien Henry, Christian Denier, Nicolas Noël Source Type: research

Nursing Home Admission and Initiation of Domiciliary Care After Ischemic Stroke – The Importance of Time to Thrombolysis
There is a paucity of data on the risk of nursing home admission or domiciliary care initiation according to time to intravenous thrombolysis for ischemic stroke. We investigated the association between time to intravenous thrombolysis and the composite of nursing home admission or domiciliary care initiation in patients with acute ischemic stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - June 15, 2021 Category: Neurology Authors: Jawad H. Butt, Christina Kruuse, Kristian Kragholm, S øren Paaske Johnsen, Søren Lund Kristensen, Eva Havers-Borgersen, Adelina Yafasova, Lauge Østergaard, Gunnar H. Gislason, Christian Torp-Pedersen, Lars Køber, Emil L. Fosbøl Source Type: research

Aspirin Use and Risk of Subdural Hematoma: Updated Meta-Analysis of Randomized Trials
Subdural hematomas are an uncommon, but a serious, bleeding complication of antithrombotic therapies. We update our previous inconclusive meta-analysis to better estimate the risk of subdural hematoma associated with aspirin use. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - June 13, 2021 Category: Neurology Authors: Robert G. Hart, Lesly A. Pearce, Philip B. Gorelick, Ben J. Connolly, Luciana Catanese Source Type: research

Validity and Test-Retest Reliability of a Thai Stroke Physical Activity Questionnaire
This study evaluated the validity and reliability of the Stroke Physical Activity Questionnaire (SPAQ), a Thai self-report questionnaire for assessing physical activity (PA) in participants with chronic stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - June 12, 2021 Category: Neurology Authors: Kusuma Potchana, Jittima Saengsuwan, Pajeemas Kittipanya-ngam Source Type: research

Predictors of Early Stroke or Death in Patients Undergoing Transcatheter Aortic Valve Implantation
The objective of this study was to estimate the predictors and incidence of stroke during the first 30 days post-TAVI. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - June 12, 2021 Category: Neurology Authors: Jean-Baptiste Ricco, H élène Castagnet, Luc Christiaens, Paola Palazzo, Matthias Lamy, Jean Mergy, Pierre Corbi, Jean-Philippe Neau Source Type: research

Effect of Sleep-Disordered Breathing During Rapid Eye Movement Sleep and Non-Rapid Eye Movement sleep on Acute Ischemic Stroke
Sleep-disordered breathing adversely impacts stroke outcomes. We investigated whether sleep-disordered breathing during rapid eye movement sleep and non-rapid eye movement sleep differentially influenced stroke outcomes. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - June 12, 2021 Category: Neurology Authors: Qin Chen, Xiang Fu, Xian-Hui Wang, Jing Chen, Jun-Ying Huang, Cheng-Jie Mao, Wan-Qing Zhai, Jie Li, Chun-Feng Liu Source Type: research

Focal cerebral arteriopathy in a young adult following SARS-CoV2 reinfection
Ten days after SARS-Cov2 reinfection with mild gastrointestinal symptoms and headache that occurred 2 months after an initial infection, a previously healthy 37-year-old woman developed fluctuating facial and upper limb paresthesia and weakness. Diffusion-weighted magnetic resonance imaging revealed ischemic lesions in the right parietal region of different stages within the same vascular territory. A cerebral angiography demonstrated an isolated focal arteriopathy with no other arterial involvement. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - June 12, 2021 Category: Neurology Authors: Carla Zanferrari, Simona Fanucchi, Maria Teresa Sollazzo, Michela Ranieri, Daniel Volterra, Luca Valvassori Source Type: research

Flow Diversion in Acute Sub Arachnoid Haemorrhage: A Single Centre Five Year Experience
This study evaluates the safety, efficacy, clinical and angiographic outcomes of acute flow-diversion at our institute. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - June 11, 2021 Category: Neurology Authors: Anil Gopinathan, Swati Jain, Sein Lwin, Kejia Teo, Cunli Yang, Vincent Nga, Tseng Tsai Yeo Source Type: research

Big Data Analysis of the Risk of Intracranial Hemorrhage in Korean Populations Taking Low-Dose Aspirin
In this study, the risk of intracranial hemorrhage in patients taking low-dose aspirin was assessed. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - June 11, 2021 Category: Neurology Authors: Tae Gon Kim, Soyoung Yu Source Type: research

A Chinese CADASIL Family with a Novel Mutation on Exon 10 of Notch3 Gene
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), which is caused by the Notch3 gene mutation, has its unique clinical and imaging characteristics. Here we present a Chinese family with a novel mutation on exon 10 of Notch3 gene. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - June 10, 2021 Category: Neurology Authors: Yuan Liu, Shicun Huang, Liqiang Yu, Tan Li, Shanshan Diao, Zhiguo Chen, Guoqing Zhou, Xihua Sheng, Yuan Xu, Qi Fang Source Type: research

Iatrogenic Middle Meningeal Arteriovenous Fistula During Embolization: Two Case Reports and Literature Review
In this report, we present two cases of iatrogenic middle meningeal arteriovenous fistula (MMAVF) with a review of the literature. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - June 10, 2021 Category: Neurology Authors: Noriaki Tashiro, Hiroto Kawano, Fumihiro Hiraoka, Yusuke Nakamura, Shuji Fukuda, Shigetoshi Yano, Hiroshi Aikawa, Yoshinori Go, Kiyoshi Kazekawa, Yoshihisa Matsumoto Tags: Case report Source Type: research

In-Hospital Acute Ischemic Stroke is Associated with Worse Outcome: Experience of a Single Center in Santiago Chile
In this study we aimed to identify the frequency of HIS and their characteristics in our center. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - June 9, 2021 Category: Neurology Authors: Alejandro Brunser, Victor Navia V, Patricia Araneda, Enrico Mazzon, Paula Mu ñoz, Gabriel Cavada, Verónica V. Olavarría, Pablo M. Lavados Source Type: research

Thrombotic Pathology is not Correlated with the Prognosis of Endovascular Treatment for Acute Ischemic Stroke
The aim of the present study was to determine whether there is a correlation between thrombotic pathology and prognosis of endovascular treatment (EVT) for acute ischemic stroke (AIS). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - June 8, 2021 Category: Neurology Authors: Yong Liu, Guangqin Li Source Type: research

Early Neurological Deterioration and Hypoperfusion Volume Ratio on Arterial Spin Labeling in Patients with Acute Ischemic Stroke
This study aimed to explore the relation between HVR and early neurological deterioration (END) in AIS patients. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - June 6, 2021 Category: Neurology Authors: Min Zhang, Wusheng Zhu, Yi Ma, Kuankuan Huang, Shan Huang, Qian Chen, Wenwei Yun, Gelin Xu Source Type: research

Criteria for Emergency Brain MRI During Stroke-Alert
Intravenous (IV) tissue plasminogen activator (tPA) should be given to patients with acute ischemic stroke (AIS) and avoided in stroke mimics (SM). Select use of emergency brain magnetic resonance imaging (eMRI-brain) in stroke-alerts aids diagnosis, but accepted utilization criteria for eMRI-brain do not currently exist. We developed criteria for eMRI-brain and report the yield of eMRI-brain in stroke-alert patients. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - June 6, 2021 Category: Neurology Authors: Evgeny Sidorov, Courtney Iser, Nidhi Kapoor, Bappaditya Ray, Juliane Chainakul, Chao Xu, Andrei V. Alexandrov, David Lee Gordon Source Type: research

Cardiac and Echocardiographic Markers in Cryptogenic Stroke with Incidental Patent Foramen Ovale
Some cardiac abnormalities could be a substrate for potential embolic source in cryptogenic stroke (CS). We evaluated whether cardiac and echocardiographic markers were associated with CS in patients with incidental patent foramen ovale (PFO) as defined using the Risk of Paradoxical Embolism (RoPE) score. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - June 6, 2021 Category: Neurology Authors: Yohei Tateishi, Yuji Ueno, Akira Tsujino, Ayako Kuriki, Yuki Kamiya, Takahiro Shimizu, Ryosuke Doijiri, Eriko Yamaguchi, Muneaki Kikuno, Yoshiaki Shimada, Hidehiro Takekawa, Masatoshi Koga, Masafumi Ihara, Koichi Hirata, Yasuhiro Hasegawa, Kazunori Toyoda Source Type: research

Anticoagulation Protocol for Secondary Prevention of Acute Ischemic Stroke Associated with Nonvalvular Atrial Fibrillation
Atrial fibrillation (AF) is a major risk factor for ischemic stroke and despite evidence for the efficacy of anticoagulation for secondary prevention of recurrent stroke in patients with AF,1 to date there is no established evidence regarding the timing for initiation of oral anticoagulants (OACs), including direct oral anticoagulants (DOACs), for secondary prevention of acute ischemic stroke associated with AF. Of concern in early initiation of OACs is the risk of recurrence balanced with the risk of hemorrhagic transformation (HT) after vascular reperfusion with reports of 3.6% symptomatic cerebral bleeding for acute use...
Source: Journal of Stroke and Cerebrovascular Diseases - June 6, 2021 Category: Neurology Authors: Teruo Kimura, Adam Tucker, Atsushi Nakagaki, Toshihide Sugimura, Shin Fukuda, Makoto Katsuno, Tsutomu Fujita, Naoto Izumi, Nozomi Suzuki, Kazuhiro Sako Source Type: research

Volume of White Matter Hyperintensities, and Cerebral Micro-Bleeds
White matter hyperintensities (WMH) indicate the presence of patchy hyper-intense areas visible on FLAIR-MRI.1,2 WMH are visible in several neurological conditions, (cerebral small vessel disease, dementia, mood and cognitive disorders)3 –5 and these are associated with other pathologies such as stroke and hypertension.6 Moreover, their prevalence increases in elderly subjects.7 However, Pantoni et al.8 speculated that the clinical significance of WMH is not completely defined, and only most severe degrees of WMH seem to have an effect on cognitive functions. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - June 6, 2021 Category: Neurology Authors: Antonella Balestrieri, Pierleone Lucatelli, Harman S. Suri, Roberto Montisci, Jasjit S. Suri, Max Wintermark, Alessandra Serra, Xiaoguang Cheng, Cheng Jinliang, Roberto Sanfilippo, Luca Saba Source Type: research

Brain Atrophy and Leukoaraiosis Correlate with Futile Stroke Thrombectomy
Although mechanical thrombectomy (MT) is a proven therapy for acute large vessel occlusion strokes, futile recanalization in the elderly is common and costly. Strategies to minimize futile recanalization may reduce unnecessary thrombectomy transfers and procedures. We evaluated whether a simple and rapid visual assessment of brain atrophy and leukoaraiosis on a plain head CT correlates with futile stroke recanalization in the elderly. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - June 5, 2021 Category: Neurology Authors: Pranita Kaginele, Andre Beer-Furlan, Krishna C. Joshi, Geetanjalee Kadam, Anoop Achanaril, Elad Levy, Muhammad Waqas, Adnan Siddiqui, Hamid Rai, Kenneth Snyder, Jason Davies, R. Webster Crowley, Bichun Ouyang, Stephan Munich, Michael Chen Source Type: research

Cerebral Structure and Function in Stroke-free Patients with Atrial Fibrillation
Atrial fibrillation (AF) is associated with high risk of dementia and brain atrophy in stroke-free patients, but the mechanisms underlying this association remain unclear. We aimed to examine the brain volume and connectivity of paramount cognitive brain networks in stroke-free patients with AF without dementia. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - June 5, 2021 Category: Neurology Authors: Danilo S. Silva, Bruna G. Caseli, Brunno M. de Campos, Wagner M. Avelar, Ana Paula B.L. Lino, Marcio L.F. Balthazar, Marcio J.O. Figueiredo, Fernando Cendes, Luiz Fernando L. Pegoraro, Ana Carolina Coan Source Type: research

Phone-Based Intervention under Nurse Guidance after Stroke (PINGS II) Study: Protocol for a Phase III Randomized Clinical Trial
Hypertension (HTN) is the leading modifiable risk factor for both incident and recurrent strokes.1 The control of HTN achieved in High-Income Countries has led to a significant diminution in the burden and mortality from strokes2 –8 unlike the scenario in many Low-and-Middle Income Countries (LMICs).9,10 In particular, sub-Saharan Africa (SSA) has the highest estimated effect size of HTN for stroke causation worldwide.11 HTN is often uncontrolled in a significant proportion of the adult population in SSA. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - June 5, 2021 Category: Neurology Authors: Fred Stephen Sarfo, Albert Akpalu, Ansumana Bockarie, Lambert Appiah, Samuel Blay Nguah, Nana Kwame Ayisi-Boateng, Sheila Adamu, Christiana Neizer, Agnes Arthur, Richard Nyamekye, Kwabena Agyenim-Boateng, Raelle Tagge, Nathaniel Adusei-Mensah, Michael Amp Source Type: research

Masthead
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - June 4, 2021 Category: Neurology Source Type: research

Editorial Board
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - June 4, 2021 Category: Neurology Source Type: research

Table of Contents
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - June 4, 2021 Category: Neurology Source Type: research

Acute Stenting and Concomitant Tirofiban Administration for the Endovascular Treatment of Acute Ischemic Stroke Related to Intracranial Artery Dissections: A Single Center Experience and Systematic Review of the Literature
Intracranial artery dissection is an uncommon cause of acute ischemic stroke. Although acute stenting of the dissected arterial segment is a therapeutic option, the associated antiplatelet regimen remains a matter of debate. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - June 3, 2021 Category: Neurology Authors: Gianmarco Bernava, Torstein R. Meling, Andrea Rosi, Jeremy Hofmeister, Hasan Yilmaz, Olivier Brina, Philippe Reymond, Michel Muster, Marco V. Corniola, Emmanuel Carrera, Karl-Olof Lovblad, Zsolt Kulcsar, Paolo Machi Source Type: research