The interplay between COVID 19 and non-communicable diseases
Since the coronavirus designated as COVID-19 emerged as a global pathogen in late 2019, there has been rapid spread across the globe. After originating in China, several high-income countries such as Italy, Spain, United States, and the United Kingdom have had high case prevalence and high levels of mortality. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 1, 2020 Category: Neurology Authors: Seemant Chaturvedi, Philip Gorelick Source Type: research

Response to letter to the editor
We would like to thank Dr. Sombat Muengtaweepongsa et al. for the interest in our article. We agree with the opinion that the contrasted Transcranial Doppler(TCD) is a safe procedure and the incidence of adverse effects is low. But we notice that in the letter, it was mentioned that up to 20% patients suffered from adverse transient neurological symptoms, such as headache, dizziness and visual aura after contrasted TCD and the number was beyond our expectation. So we are curious about the reference of this statement. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - June 30, 2020 Category: Neurology Authors: Zheng-zheng Xuan, Xiu-yun Mo, Jing-xin Zhong Tags: Letter to the Editor Source Type: research

Bilateral posterior infarction in a SARS-Cov-2 infected patient: discussion about an unusual case
We present a case of bilateral occipito-temporal infarction revealed by a sudden cortical blindness with haemorrhagic transformation after intravenous thrombolysis in a diabetic patient infected by Covid-19. Differential diagnoses are discussed in front of this unusual presentation and evolution. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - June 28, 2020 Category: Neurology Authors: Claire Bonardel, Mathieu Bonnerot, Marie Ludwig, Wilfried Vadot, Gaspard Beaune, Bruno Chanzy, Lucie Cornut, H élène Baysson, Magali Farines, Isabelle Combes, Gabriel Macheda, Fabrice Bing Tags: Case Report Source Type: research

Response to the letter to the editor: “Safety of direct oral anticoagulant - and antiplatelet therapy in patients with atrial fibrillation treated by carotid artery stenting”
We would like to thank Shrivastava et al. for their valuable comments. We agree with their comments, and would like to provide some additional information. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - June 26, 2020 Category: Neurology Authors: Kouhei Nii, Yusuke Takemura, Toshio Higashi Source Type: research

COVID-19 Impact on Stroke Presentations
As Covid-19 evolved into a world-wide pandemic, hospitals reported marked declines in strokes, only to be followed by reports of increased numbers of young people presenting with large-vessel occlusions. We reviewed our patient data-base to determine if similar or other novel trends were present. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - June 25, 2020 Category: Neurology Authors: Sheryl Strasser, Laszlo Miskolczi, John Cunha, Lori Justynski Source Type: research

COVID-19 pandemic and burden of non-communicable diseases: An ecological study on data of 185 countries
Preventive measures against COVID-19 should protect the public from the dual burden of communicable and non-communicable diseases, particularly in the elderly. In addition to active COVID-19 surveillance, policymakers should utilize this evidence as a guide for prevention and coordination of health services. This model is timely, as many countries have begun to reduce social isolation. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - June 25, 2020 Category: Neurology Authors: M. Reza Azarpazhooh, Negar Morovatdar, Abolfazl Avan, Thanh G Phan, Afshin A. Divani, Nawaf Yassi, Saverio Stranges, Brian Silver, Jos é Biller, Masoud Tokazebani Belasi, Sepideh Kazemi Neya, Bita Khorram, Asher Frydman, Yongchai Nilanont, Elisa Onorati, Source Type: research

Acute Stroke Care Algorithm in a Private Tertiary Hospital in the Philippines During the COVID-19 Pandemic: A Third World Country Experience
Since March 2020, we have experienced an influx of COVID-19 positive patients. As of April 27, 2020 the COVID-19 pandemic has claimed the lives of at least 27 healthcare professionals while infecting 1080 healthcare professionals in the Philippines.1 Despite attempts to formalize protocols and treatment pathways to ensure the safety of healthcare professionals while optimizing patient care, Philippine healthcare workers from every department still continue to suffer from COVID-19 infections. These affect not only acute care but also emergency response systems such as the brain attack code. (Source: Journal of Stroke and Ce...
Source: Journal of Stroke and Cerebrovascular Diseases - June 20, 2020 Category: Neurology Authors: Christian Oliver C. Co, Jeryl Ritzi T. Yu, Cristina Macrohon-Valdez, Lina C. Laxamana, Vincent Paul E. De Guzman, Remy Margarette M. Berroya-Moreno, Manuel M. Mariano, Peter Paul Dela Paz Rivera, Joana Lyn M. Racpan-Cauntay, Karen Czarina S. Ilano, Evita Tags: Original Article Source Type: research

Universal laboratory testing for SARS-CoV-2 in hyperacute stroke during the COVID-19 pandemic
The coronavirus disease 2019 (COVID-19) pandemic necessitates organizational and structural adjustments to local health care systems to protect medical professionals and patients from infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (1). Particularly older individuals and those with cardiovascular comorbidities are thought to be at increased risk of COVID-19 (2). Consequently, stroke patients can be considered an at-risk population and might benefit from infection control screens at hospital entry (3,4). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - June 20, 2020 Category: Neurology Authors: Kristian Barlinn, Timo Siepmann, Lars-Peder Pallesen, Simon Winzer, Annahita Sedghi, Percy Schroettner, Kristina Hochauf-Stange, Alexandra Prakapenia, Haidar Moustafa, Katja de With, Jennifer Linn, Heinz Reichmann, Jessica Barlinn, Volker Puetz Tags: Original Article Source Type: research

Acute Stroke Care in a New York City Comprehensive Stroke Center during the COVID-19 Pandemic
The coronavirus disease-2019 (COVID-19) pandemic caused unprecedented demand and burden on emergency health care services in New York City. We aim to describe our experience providing acute stroke care at a comprehensive stroke center (CSC) and the impact of the pandemic on the quality of care for patients presenting with acute ischemic stroke (AIS). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - June 20, 2020 Category: Neurology Authors: Shashank Agarwal, Erica Scher, Nirmala Rossan-Raghunath, Dilshad Marolia, Mariya Butnar, Jose Torres, Cen Zhang, Sun Kim, Matthew Sanger, Kelley Humbert, Omar Tanweer, Maksim Shapiro, Eytan Raz, Erez Nossek, Peter K. Nelson, Howard A. Riina, Adam de Haven Source Type: research

Obituary
It is with great sadness that I notify you of the recent passing of Murray Samuel Flaster, MD, PhD, on May 17, 2020. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - June 19, 2020 Category: Neurology Authors: Michael J. Schneck Source Type: research

Stroke and COVID19: not only a large-vessel disease
Recent evidence has underlined the association between large-vessel stroke and COVID-19, probably due to a proinflammatory and prothrombotic microenvironment induced by SARS-CoV-2. Here, we report the case of a young fit woman affected by COVID-19 without any flu-like symptom, who suffered from speech disorder and left hemiparesis. Brain magnetic resonance evidenced two small acute brain infarctions in right perirolandic cortex without signs of previous ischemic lesions and hemorrhagic infarction. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - June 19, 2020 Category: Neurology Authors: Giovanni Frisullo, Simone Bellavia, Irene Scala, Carla Piano, Roberta Morosetti, Valerio Brunetti, Paolo Calabresi, Giacomo Della Marca Tags: Case Report Source Type: research

Re: Safety of direct oral anticoagulant - and antiplatelet therapy in patients with atrial fibrillation treated by carotid artery stenting
Dear Editor (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - June 17, 2020 Category: Neurology Authors: Adesh Shrivastava, Amit Agrawal, Luis Rafael Moscote-Salazar Tags: Letter to the Editor Source Type: research

“COVID-19 and cervical artery dissection- A causative association?”
COVID-19 is a pandemic disease which predominantly affects the respiratory system, however it also causes multi-organ dysfunction in a subset of patients. There is a growing evidence that it increases the propensity of strokes in younger patients. Besides producing a prothrombotic state, arterial dissection could be one of its many manifestations, increasing the risks of stroke. Herein, we report the first case of spontaneous bilateral vertebral artery dissection in a patient with COVID-19. 39-year female presented with spontaneous bilateral vertebral artery dissections without any instigating traumatic events and no histo...
Source: Journal of Stroke and Cerebrovascular Diseases - June 13, 2020 Category: Neurology Authors: Pratit Patel, Priyank Khandelwal, Gaurav Gupta, Amit Singla Source Type: research

Hemorrhagic Stroke in Setting of Severe COVID-19 Infection Requiring Extracorporeal Membrane Oxygenation (ECMO)
To highlight the increased risk of hemorrhagic stroke secondary to postulated COVID-19 mediated vasculopathy with concomitant ECMO related bleeding complications. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - June 6, 2020 Category: Neurology Authors: Muhammad J. Zahid, Anam Baig, Nestor Galvez-Jimenez, Nydia Martinez Tags: Case Report Source Type: research

A protocol for acute stroke unit care during the COVID-19 pandemic
Limited resources, manpower shortages, tight infection control, physical distancing regulations and stay-at-home policies, we are all adapting our systems to care for stroke patients during this challenging time. There are different phases in the care of stroke patients and these may overlap; hyperacute care often involving reperfusion treatments, acute stroke unit (ASU) management as an inpatient and subsequently rehabilitation focus in an inpatient or outpatient setting. There have been reports providing guidance and protocols for hyperacute reperfusion treatment provision such as the management of stroke activations, co...
Source: Journal of Stroke and Cerebrovascular Diseases - June 5, 2020 Category: Neurology Authors: Deidre Anne De Silva, Tan Il Fan, Shamala D/O Thilarajah Tags: Original Article Source Type: research

Subarachnoid hemorrhage guidance in the era of the COVID-19 pandemic -An opinion to mitigate exposure and conserve personal protective equipment
Aneurysmal subarachnoid hemorrhage (SAH) patients require frequent neurological examinations, neuroradiographic diagnostic testing and lengthy intensive care unit stay. Previously established SAH treatment protocols are impractical to impossible to adhere to in the current COVID-19 crisis due to the need for infection containment and shortage of critical care resources, including personal protective equipment (PPE). Centers need to adopt modified protocols to optimize SAH care and outcomes during this crisis. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - June 5, 2020 Category: Neurology Authors: Thanh N. Nguyen, Ashutosh P. Jadhav, Hormuzdiyar H. Dasenbrock, Raul G. Nogueira, Mohamad Abdalkader, Alice Ma, Anna M. Cervantes-Arslanian, David M. Greer, Ali Daneshmand, Dileep R. Yavagal, Tudor G. Jovin, Osama O. Zaidat, Sherry Hsiang-Yi Chou Tags: Review Article Source Type: research

Reversible Cerebral Vasoconstriction Syndrome and Dissection in the Setting of COVID-19 Infection
The current COVID-19 pandemic has recently brought to attention the myriad of neuro- logic sequelae associated with Coronavirus infection including the predilection for stroke, particularly in young patients. Reversible cerebral vasoconstriction syndrome (RCVS) is a well-described clinical syndrome leading to vasoconstriction in the intracra- nial vessels, and has been associated with convexity subarachnoid hemorrhage and oc- casionally cervical artery dissection. It is usually reported in the context of a trigger such as medications, recreational drugs, or the postpartum state; however, it has not been described in COVID-...
Source: Journal of Stroke and Cerebrovascular Diseases - June 5, 2020 Category: Neurology Authors: Katarina Dakay, Gurmeen Kaur, Edwin Gulko, Justin Santarelli, Christian Bowers, Stephan A Mayer, Chirag D Gandhi, Fawaz Al-Mufti Tags: Case Report Source Type: research

Masthead
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - June 4, 2020 Category: Neurology Source Type: research

Editorial Board
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - June 4, 2020 Category: Neurology Source Type: research

Table of Contents
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - June 4, 2020 Category: Neurology Source Type: research

Optimization of Resources and Modifications in Acute Ischemic Stroke Care in Response to the Global COVID-19 Pandemic
Background: The COVID-19 pandemic has presented unprecedented challenges to healthcare organizations worldwide. A steadily rising number of patients requiring intensive care, a large proportion from racial and ethnic minorities, demands creative solutions to provide high-quality care while ensuring healthcare worker safety in the face of limited resources. Boston Medical Center has been particularly affected due to the underserved patient population we care for and the increased risk of ischemic stroke in patients with COVID-19 infection. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - May 23, 2020 Category: Neurology Authors: Thomas Ford, Gioacchino Curiale, Thanh N Nguyen, Hugo Aparicio, Emily K. Hamlyn, Suhas Gangadhara, Anna M Cervantes-Arslanian, David Greer, Jose Rafael Romero, Julie G Shulman Source Type: research

Unprotected stroke management in an undiagnosed case of Severe Acute Respiratory Syndrome Coronavirus 2 infection
We report the case of a 79-year-old woman, who was admitted for a wake-up stroke due to occlusion of the left middle cerebral artery. She was treated outside the COVID-19-dedicated track of the hospital because she had no concomitant signs or symptoms suggestive of SARS-CoV-2 infection nor recent contact with other infected individuals. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - May 23, 2020 Category: Neurology Authors: Claudia Papi, Gregorio Spagni, Andrea Alexandre, Paolo Calabresi, Giacomo Della Marca, Aldobrando Broccolini Source Type: research

Acute ophthalmic artery occlusion in a Covid-19 patient on apixaban
We report a case of acute OAO in a young patient with a severe form of Covid-19 infection that was on therapeutic anticoagulation with apixaban for deep venous thrombosis (DVT). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - May 23, 2020 Category: Neurology Authors: Oana M. Dumitrascu, Oksana Volod, Swaraj Bose, Yao Wang, Val érie Biousse, Patrick D. Lyden Source Type: research

Hemorrhagic stroke and anticoagulation in COVID-19
We present a retrospective study of 33 patients positive for COVID-19 with neuroimaging-documented ICH and examine anticoagulation use in this population. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - May 23, 2020 Category: Neurology Authors: Siddhant Dogra, Rajan Jain, Meng Cao, Seda Bilaloglu, David Zagzag, Sarah Hochman, Ariane Lewis, Kara Melmed, Katherine Hochman, Leora Horwitz, Steven Galetta, Jeffrey Berger Tags: Hemorrhagic stroke in COVID-19 Source Type: research

Cerebral Venous Thrombosis: Atypical Presentation of COVID-19 in the Young
Identify clinical and radiographic features of venous infarct as a presenting feature of COVID-19 in the young. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - May 23, 2020 Category: Neurology Authors: David E. Klein, Richard Libman, Claudia Kirsch, Rohan Arora Tags: Case Report Source Type: research

Thalamic perforating artery stroke on computed tomography perfusion in a patient with coronavirus disease 2019
We present a case illustrating the value of CT perfusion to identify acute small subcortical infarcts in a patient with COVID-19 admitted to an intensive care unit for bilateral pneumonia and pulmonary embolism presenting with sudden right limb weakness. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - May 21, 2020 Category: Neurology Authors: Salvatore Rudilosso, Diana Esteller, Xabier Urra, Ángel Chamorro Tags: Case Report Source Type: research

Masthead
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - May 20, 2020 Category: Neurology Source Type: research

Editorial Board
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - May 20, 2020 Category: Neurology Source Type: research

Table of Contents
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - May 20, 2020 Category: Neurology Source Type: research

Antioxidative effects of a novel dietary supplement Neumentix in a mouse stroke model
Stroke is the leading cause of disability and death worldwide,1 but current available therapies are limited.2 Oxidative stress is the major component of the stroke cascade, especially in the acute phase of an ischemic stroke.3,4 During brain ischemia and reperfusion, reactive oxygen species (ROS), also referred to as oxygen free radicals, are overproduced, while the endogenous antioxidative defense systems are disrupted.5 ROS generates toxic aldehyde 4-hydroxynonenal (4-HNE),6 glycated protein N(epsilon)-(carboxymethyl) lysine (CML),7 and oxidized DNA 8-hydroxy-2-deoxyguanosine (8-OHdG). (Source: Journal of Stroke and Cere...
Source: Journal of Stroke and Cerebrovascular Diseases - May 18, 2020 Category: Neurology Authors: Yuki Taira, Toru Yamashita, Yuting Bian, Jingwei Shang, Namiko Matsumoto, Ryo Sasaki, Koh Tadokoro, Emi Nomura, Keiichiro Tsunoda, Yoshio Omote, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Koji Abe Source Type: research

Postoperative Functional Outcomes and Prognostic Factors in Two Types of Adult Moyamoya Diseases
Moyamoya disease (MMD) is characterized by chronic progressive stenosis or occlusion of the terminal portion of the bilateral internal carotid arteries, leading to the formation of an abnormal vascular network at the base of the brain.1 Ischemic and hemorrhagic symptoms are the most common symptoms in adult MMD patients.2 (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - May 18, 2020 Category: Neurology Authors: Miaoyi Zhang, Jie Tang, Na Liu, Yang Xue, Xue Ren, Jianhui Fu Source Type: research

Rapidly Resolving and Recurrent Contralateral Subdural Hematoma From Disseminated Intravascular Coagulation
Subdural hematoma (SDH) is defined by the collection of blood between the dura and arachnoid layers, arising from a tear in the bridging veins.1 SDH can occur in both the pediatric and elderly populations. In the elderly, brain atrophy and a wide cavum of the subarachnoid space could cause the arachnoid membrane to tear with minor injury.2 SDH may be bilateral or recurrent, and may occur spontaneously or result from trauma or secondary to anticoagulation use.3 Atraumatic SDH may be due to vascular disorders, coagulopathies, or intracranial hypotension. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - May 18, 2020 Category: Neurology Authors: Rana Hanna Al Shaikh, Tasneem F. Hasan, Tara L. Becker, Lauren K. Ng Tucker, James F. Meschia, Rabih G. Tawk, Ernesto Ayala, William D. Freeman Tags: Case Report Source Type: research

Association between CYP2C9 polymorphisms and ischemic stroke following endovascular neurointervention
Polymorphisms in the CYP2C9 gene may be associated with adverse vascular events following endovascular procedures independent of antiplatelet therapy. We aimed to investigate the impact of CYP2C9 loss-of-function polymorphisms on adverse vascular events following neurointervention. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - May 18, 2020 Category: Neurology Authors: Subhashaan Sreedharan, Leonid Churilov, Jianxiong Chan, Marian Todaro, Alan Coulthard, Jeffrey Hocking, Kate Mahady, Peter Mitchell, Richard Dowling, Steven Bush, Patrick Kwan, Bernard Yan Source Type: research

Opalski Syndrome Treated with Intravenous Recombinant Tissue Type Plasminogen Activator —Case Report and Review of Literature
A 65-year-old man with a history of Wallenberg syndrome caused by vertebral artery dissection at 62 years old was admitted to our hospital with nausea, vertigo, right facial dysesthesia, right hemiplegia, crossed sensory disturbance (sensory loss and numbness in the right face and left body below the neck), and right limb ataxia. Magnetic resonance imaging (MRI) performed 80 minutes after onset revealed no acute ischemic stroke lesions, but magnetic resonance angiography (MRA) demonstrated complete occlusion of the right vertebral artery. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - May 17, 2020 Category: Neurology Authors: Daisuke Hara, Masashi Akamatsu, Heisuke Mizukami, Bunta Kato, Takaaki Suzuki, Jun Oshima, Yukari Akasu, Yasuhiro Hasegawa Tags: Case Report Source Type: research

Alterations in inflammatory markers and clinical outcome after spontaneous intracerebral hemorrhage – Preliminary results
In this study, we investigated alterations of inflammatory markers in the blood and clinical outcome after an intracerebral hemorrhage. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - May 17, 2020 Category: Neurology Authors: Mareike M üller, Jorge-Humberto Tapia-Perez, Can Yildiz, Ali Rashidi, Michael Luchtmann Source Type: research

Analysis of Risk Factors Independently Associated with Cognitive Impairment in Patients with Permanent Atrial Fibrillation: A Cross-sectional Observational Study
Atrial Fibrillation (AF) is associated with an increased risk of stroke and development of cognitive impairment. Our cross-sectional study aims to identify risk factors for cognitive impairment in patients with permanent AF. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - May 17, 2020 Category: Neurology Authors: Renata Petroni, Roberta Magnano, Laura Pezzi, Angelo Petroni, Michele Di Mauro, Antonella Mattei, Fabiana Fiasca, Anna Maria Angelone, Sabina Gallina, Maria Penco, Silvio Romano Source Type: research

A case of simple stenting for ruptured basilar perforator aneurysm
We report a case of a basilar perforator artery aneurysm that was treated successfully using simple stenting to induce a rectifying effect without using a coil. In this case, coiling for the aneurysm was attempted initially, but it failed because of anatomical and practical problems. After placement of two stents in the basilar artery, the aneurysm was occluded completely without any neurological deficits at 100 days after the procedure. Although superselective coil embolization is ideal even in a small perforator aneurysm, simple stenting for a parent artery is a preferable treatment, especially in challenging cases for c...
Source: Journal of Stroke and Cerebrovascular Diseases - May 16, 2020 Category: Neurology Authors: Yohei Inoue, Noboru Kusaka, Kenta Ikushima, Hisanori Edaki, Yukei Shinji, Hisakazu Itami, Shinji Otsuka, Tsukasa Nishiura, Kotaro Ogihara Tags: Case Report Source Type: research

Recurrent cerebrovascular events in patients after percutaneous closure of patent foramen ovale
Patent foramen ovale (PFO) is a potential cause of cryptogenic cerebrovascular events (c-CVEs). A score has been developed to identify stroke-related versus incidental PFO in c-CVEs. The Risk of Paradoxical Embolism (RoPE) score indicates that otherwise healthy young adults with a high score are likely to have pathogenic PFO.1 –3 Until recently, there was a lack of evidence for routine closure of PFO in patients who suffered from c-CVEs.4–6 However, three recent randomized studies showed a benefit of transcatheter PFO closure compared with medical therapy. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - May 16, 2020 Category: Neurology Authors: Alexia Karagianni, Zacharias Mandalenakis, Mikael Dellborg, Naqibullah Mirzada, Magnus Carl Johansson, Peter Eriksson Source Type: research

Factors Associated with Pre-Hospital Delay and Intravenous Thrombolysis in China
Pre-hospital delay was a critical factor affecting stroke patients receiving intravenous thrombolytic therapy. The aim of this study was to explore the factors associated with pre-hospital delay and thrombolysis in China. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - May 16, 2020 Category: Neurology Authors: Yafang Zhu, Xia Zhang, Shoujiang You, Xiaowei Cao, Xuan Wang, Wenjie Gong, Yan Qin, Xiaojun Huang, Yongjun Cao, Rongfang Shi Source Type: research

Temporal Trends in the Risk Factors and Clinical Characteristics of Ischemic Stroke in Young Adults
This study aimed to analyze the risk factors of ischemic stroke in young adults of different ages; explore the changes in these risk factors with time; analyze the clinical characteristics of ischemic stroke in young adults; and assess how to better prevent ischemic stroke in young adults. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - May 16, 2020 Category: Neurology Authors: Qiuling Zhang, Yao Liu, Min Jiang, Yun Liu, Shuangshuang Gu, Hanwen Tong, Hengjun Liu Source Type: research

The Potential Value of D-Dimer to Fibrinogen Ratio in Diagnosis of Acute Ischemic Stroke
At present, there is no hematology marker with high specificity to the diagnosis and differential diagnosis of acute ischemic stroke (AIS). How to use the existing test items to improve the diagnosis efficiency worthy of discussion. D-Dimer (DD) and fibrinogen (FIB) were the common indicators in thrombotic diseases, but D-dimer to fibrinogen ratio (D/F) in AIS has not been used in clinical practice. In this work, we focus on the evaluation of D/F. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - May 16, 2020 Category: Neurology Authors: Xing Chen, Sijin Li, Wei Chen, Fei Xu, Yan Wang, Guoying Zou, Biqiong Ren Source Type: research

Low Serum Eicosapentaenoic Acid Levels in Cryptogenic Stroke with Active Cancer
Since Armand Trousseau first described migratory superficial thrombophlebitis in 1865, patients with malignant cancer have been known to be in a hypercoagulable state and at risk for the development of cancer-associated thrombosis.1 Approximately 7% of cancer patients have symptomatic cerebrovascular diseases during the clinical course of cancer, and 15% have cerebrovascular lesions at autopsy.2 Previous studies have demonstrated that cancer patients with cryptogenic ischemic stroke often have high serum D-dimer levels and multiple vascular lesions and show cryptogenic stroke etiology, which seems to be due to a hypercoagu...
Source: Journal of Stroke and Cerebrovascular Diseases - May 15, 2020 Category: Neurology Authors: Tesseki Izumi, Hitoki Nanaura, Naohiko Iguchi, Maki Ozaki, Kazuma Sugie Source Type: research

Natural History of Infratentorial Intracerebral Hemorrhages: Two Subgroups with Distinct Presentations and Outcomes
Infratentorial intracerebral hemorrhage (ICH) is associated with worse prognosis than supratentorial ICH; however, infratentorial ICH is often excluded or underrepresented in clinical trials of ICH. We sought to evaluate the natural history of infratentorial ICH stratified by brainstem or cerebellar location using a prospective observational study inclusive of all spontaneous ICH. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - May 15, 2020 Category: Neurology Authors: Viren D. Patel, Roxanna M. Garcia, Dionne E. Swor, Eric M. Liotta, Matthew B. Maas, Andrew Naidech Source Type: research

A Novel Heterozygous Variant in Exon 19 of NOTCH3 in a Saudi Family with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy
Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL; OMIM #125310) is the most common cause of monogenic familial cerebral small vessel disease. It typically manifests at middle adulthood with highly variable clinical features including migraine with aura, recurrent transient ischemic attacks or ischemic strokes, mood disorders, and progressive cognitive decline. It is caused by mutations in the NOTCH3 gene, which maps to the short arm of chromosome 19 and encode for epidermal growth factor-like repeats. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - May 14, 2020 Category: Neurology Authors: Hussein Algahtani, Bader Shirah, Suzan Y. Alharbi, Mohammad H. Al-Qahtani, Angham Abdulrahman Abdulkareem, Muhammad Imran Naseer Tags: Case Report Source Type: research

Impact of endovascular reperfusion on low National Institutes of Health Stroke Scale score large-vessel occlusion stroke
The benefit of mechanical thrombectomy (MT) in patients presenting with mild ischemic stroke symptoms (National Institutes of Health Stroke Scale [NIHSS] score (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - May 14, 2020 Category: Neurology Authors: Felix Chin, Muhammad Waqas, Ryan Chou, Peter G. Gerace, Hamid H. Rai, Kunal Vakharia, Rimal H. Dossani, Jason M. Davies, Kenneth V. Snyder, Adnan H. Siddiqui, Elad I. Levy Source Type: research

Distal arterial occlusions in patients with mild strokes – is endovascular therapy superior to thrombolysis alone?
Safety and efficacy of endovascular thrombectomy (EVT) in patients with mild stroke syndromes is unclear, especially in distal vessel occlusions. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - May 14, 2020 Category: Neurology Authors: Simon Nagel, Johannes Pfaff, Christian Herweh, Simon Schieber, Sibu Mundiyanapurath, Silvia Sch önenberger, Fatih Seker, Markus A. Möhlenbruch, Peter A. Ringleb Source Type: research

A Case of Delayed Intraparenchymal Hemorrhage Due to Hyperperfusion After Flow Diverter Treatment
We present the case of a 54-year-old woman with a partially thrombosed large internal carotid artery aneurysm. She presented intraparenchymal hemorrhage in the right parietal lobe three days after the successful FD treatment. We performed endoscopic hematoma removal, and then her consciousness disturbance was fully recovered. IMP single-photon emission computed tomography showed significant increase of cerebral blood flow in the right hemisphere. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - May 14, 2020 Category: Neurology Authors: Takaaki Itazu, Yukiko Enomoto, Keita Yamauchi, Yusuke Egashira, Toru Iwama Tags: Case Report Source Type: research

Mechanical Thrombectomy in Nonagenarians: A Propensity Score Matched Analysis
Improvement in medical care and socio-economic growth has led to increased average life expectancy worldwide, surpassing 90 years in some countries. According to U.S. census bureau data, 1.7% of the U.S. population was over age 85 in 2010, representing a 30% increase from 2000. With increasing age, the incidence and prevalence of acute ischemic stroke (AIS) is also higher. In general, older patients also tend to have more severe strokes, smaller penumbra, and relatively faster conversion to ischemic core due to decreased cerebrovascular reserve. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - May 14, 2020 Category: Neurology Authors: Shashank Agarwal, Jeffrey Huang, Erica Scher, Jeffrey Farkas, Karthikeyan Arcot, David Gordon, David Turkel-Parrella, Ambooj Tiwari, Jeremy Liff, Shadi Yaghi, Seena Dehkharghani, Koto Ishida, Howard Riina, Jennifer A. Frontera Source Type: research

Association between obstructive sleep apnea and risk of post-stroke depression: A hospital-based study in ischemic stroke patients
This study aimed to detect the correlation between OSA severity and post-stroke depression (PSD) in ischemic stroke patients. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - May 14, 2020 Category: Neurology Authors: Chuanyou Li, Yuanyue Liu, Pengfei Xu, Qiqi Fan, Pengyu Gong, Caixia Ding, Lei Sheng, Xiaohao Zhang Source Type: research

High on-clopidogrel platelet reactivity in ischaemic stroke or transient ischaemic attack: Systematic review and meta-analysis
To assess the prevalence of high on-clopidogrel platelet reactivity (HCPR) in patients with ischaemic stroke or transient ischaemic attack (IS/TIA), their outcome and genetic basis of on-treatment response variability in IS/TIA patients. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - May 14, 2020 Category: Neurology Authors: Vafa Alakbarzade, Xuya Huang, Irina Chis Ster, Meriel McEntagart, Anthony C. Pereira Source Type: research