Paradoxical Brain Embolism Caused by Isolated Pulmonary Arteriovenous Fistula Successfully Treated with Recombinant Tissue Plasminogen Activator
Pulmonary arteriovenous fistula (PAVF), a vessel malformation connecting the pulmonary circulation to the systemic circulation while bypassing the pulmonary capillaries, can cause paradoxical cerebral infarction. It is often associated with hereditary hemorrhagic telangiectasia (HHT), a genetic disease characterized by multiple dermal, mucosal, and visceral telangiectasia causing recurrent bleeding. Paradoxical cerebral embolism caused by PAVF without HHT is rare. Here, we report a patient with isolated PAVF who experienced an ischemic stroke caused by a paradoxical embolism from deep venous thrombosis; the patient was suc...
Source: Journal of Stroke and Cerebrovascular Diseases - April 18, 2019 Category: Neurology Authors: Itsuki Hasegawa, Takato Abe, Toshikazu Mino, Kousuke Okamoto, Akitoshi Takeda, Yoshiaki Itoh Tags: Case Report Source Type: research

Effectiveness of Nonvitamin K Antagonist Oral Anticoagulants and Warfarin for Preventing Further Cerebral Microbleeds in Acute Ischemic Stroke Patients with Nonvalvular Atrial Fibrillation and At Least One Microbleed: CMB-NOW Multisite Pilot Trial
Nonvitamin K antagonist oral anticoagulants (NOACs) are considered superior, or at least noninferior, to warfarin in preventing stroke or systemic embolism in patients with nonvalvular atrial fibrillation. Here, we recruited acute ischemic stroke patients with nonvalvular atrial fibrillation and at least one cerebral microbleed (CMB), and evaluated the proportion of patients who had an increased number of CMBs (%) after receiving anticoagulant therapy with NOACs or with warfarin for 12 months. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 18, 2019 Category: Neurology Authors: Mutsumi Yokoyama, Atsushi Mizuma, Tohru Terao, Fumiaki Tanaka, Kazutoshi Nishiyama, Yasuhiro Hasegawa, Eiichiro Nagata, Shigeru Nogawa, Hiroyuki Kobayashi, Noriharu Yanagimachi, Takashi Okazaki, Kazuo Kitagawa, Shunya Takizawa, for the CMB-NOW Study Inves Source Type: research

Risk Factors for Pressure Sores in Hospitalized Acute Ischemic Stroke Patients
Acute ischemic stroke patients are a group at high risk for pressure sores. It is important to identify risk factors for pressure sores in acute ischemic stroke patients in order to facilitate early adoption of appropriate preventive and treatment measures. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 17, 2019 Category: Neurology Authors: Xiaoling Liao, Yi Ju, Gaifen Liu, Xingquan Zhao, Yilong Wang, Yongjun Wang Source Type: research

Association Between Baseline Serum Ferritin and Short-term Outcome of Intracerebral Hemorrhage: A Meta-Analysis
Background: Intracerebral hemorrhage is a devastating disease. In recent years, the association of between baseline serum ferritin and prognosis of intracerebral hemorrhage is an interesting issue. Although some of the studies have shown that baseline serum ferritin can predict the prognosis of intracerebral hemorrhage, there is no clear evidence that baseline serum ferritin can be used as an independent predictor of intracerebral hemorrhage. Methods: Electronic databases through November 2018 were searched to identify relevant studies that examined association between baseline serum ferritin and prognosis of intracerebral...
Source: Journal of Stroke and Cerebrovascular Diseases - April 15, 2019 Category: Neurology Authors: Mijuan Zhang, Wei Li, Tao Wang, Qian Zhang Tags: Review Article Source Type: research

Increasing the Risk of Stroke by Opium Addiction
Stroke is among the leading causes of mortality and morbidity in the world. Besides the identified risk factor, Ischemic stroke evidence show drug use develops or exacerbates the atherosclerotic process. The current study aimed at comparing cerebrovascular ultrasounds ’ changes in addicted and nonaddicted people who developed ischemic stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 15, 2019 Category: Neurology Authors: Seyed Mohammad Mousavi-Mirzaei, Abolfazl Talebi, Alireza Amirabadizadeh, Samaneh Nakhaee, Ghodsieh Azarkar, Omid Mehrpour Source Type: research

Masthead
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 13, 2019 Category: Neurology Source Type: research

Editorial Board
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 13, 2019 Category: Neurology Source Type: research

Table of Contents
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 13, 2019 Category: Neurology Source Type: research

Comment on “The Enhancing Effect of Focused Ultrasound on TNK-Tissue Plasminogen Activator-Induced Thrombolysis Using an In Vitro circulating Flow Model”
The objective of the study by Papadopoulos et al. was to evaluate the effect of various parameters such as temperature, focused ultrasound (FUS) energy, FUS frequency, acoustic power, and microbubble administration on tenecteplase (TNK)-tissue plasminogen activator-mediated thrombolysis and therefore, to establish a treatment protocol that maximize thrombolysis efficacy. For this purpose, an in vitro circulating flow clot model was designed to reproduce a middle cerebral artery occlusion. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 13, 2019 Category: Neurology Authors: Nicolas Papadopoulos, Christakis Damianou Tags: Letter to the Editor Source Type: research

Recent Trends in Electively Treated Unruptured Intracranial Aneurysms
Background and Purpose: To determine recent treatment and outcome trends in patients undergoing elective surgical clipping (SC) or endovascular therapy (EVT) for unruptured intracranial aneurysms (UIAs) in the United States. Methods: Data were extracted and analyzed from the National Inpatient Sample, Healthcare Cost and Utilization Project, Agency for Healthcare Research and Quality for all patients admitted for elective EVT or SC of UIAs between 2011 and 2014. Treatment trends, in-hospital mortality, complication rates, length of stay (LOS) and total hospital costs were evaluated and analyzed. (Source: Journal of Stroke ...
Source: Journal of Stroke and Cerebrovascular Diseases - April 11, 2019 Category: Neurology Authors: Hisham Salahuddin, Nauman Siddiqui, Alicia C. Castonguay, Mark Johnson, Syed F. Zaidi, Mouhammad A. Jumaa Source Type: research

Pretreatment Blood Pressure is a Simple Predictor of Hemorrhagic Infarction after Intravenous Recombinant Tissue Plasminogen Activator (rt-PA) Therapy
Hemorrhagic infarction (HI) is among the most severe complications that can occur following the administration of intravenous recombinant tissue plasminogen activator (rt-PA). In the present study, we aimed to determine the optimal cut-off points of blood pressure (BP) for HI after rt-PA treatment, and to compare our findings with those for other prediction models. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 11, 2019 Category: Neurology Authors: Ryo Ohtani, Michikazu Nakamura, Shinsuke Nirengi, Osamu Kawakami, Jumpei Togawa, Kento Doi, Makoto Sainouchi, Yasuhiro Kuwata, Masaki Takata, Yuichi Masuda, Ryota Matsunari, Kiyoaki Takeda, Tetsuya Tsukahara, Naoki Sakane Source Type: research

Improving Prognostic Evaluation by 4D CTA for Endovascular Treatment in Acute Ischemic Stroke Patients: A Preliminary Study
Objective: We aim to use 4D CTA with a comprehensive and objective scoring system to assess collateral circulation, and explore the value of prognosis prediction in endovascular treated patients. Methods: Thirty-four patients with unilateral anterior circulation large vessels occlusion were reviewed in this study retrospectively. Single-phase CTA (sCTA) and 4D CTA acquired by CT perfusion scanning were analyzed for collateral circulation assessment. The collateral vessels were scored 0-4 according to modified collateral circulation scoring based on 4D CTA. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 10, 2019 Category: Neurology Authors: Ruoyao Cao, Peng Qi, Yinhong Liu, Xinxin Ma, Zhengyin Shen, Juan Chen Source Type: research

Comment on “The Enhancing Effect of Focused Ultrasound on TNK-Tissue Plasminogen Activator-Induced Thrombolysis using an In Vitro Circulating Flow Model”
We recently read the article by Papadopoulos et al published in the Journal of Stroke and Cerebrovascular Diseases.1 However, we have some concerns about the methodology and their potential consequences on the interpretation of results. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 10, 2019 Category: Neurology Authors: Laurent Auboire, Jean-Michel Escoffre Tags: Letter to the Editor Source Type: research

Predictors of Oral Feeding Resumption after Stroke in a Rehabilitation Hospital: A Retrospective Study
Background: Dysphagia is common after stroke, requiring exclusive enteral feeding in 20% of patients. Recovery of oral feeding is associated with increased quality of life, better functional outcomes, and decreased mortality rates. However, evidence is heterogeneous and not conclusive on which factors are predictive of oral feeding recovery for stroke patients in rehabilitation units. Aim: To investigate predictors of complete oral feeding recovery. Design: Retrospective study. Setting: Intensive inpatient rehabilitation hospital. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 10, 2019 Category: Neurology Authors: Irene Calvo, Nicole Pizzorni, Giulia Gilardone, Flavia Mayer, Nicola Vanacore, Valentina Buraschi, Marco Gilardone, Massimo Corbo Source Type: research

Predictors for Functional Outcome in Patients with Aneurysmal Subarachnoid Hemorrhage Who Completed In-Hospital Rehabilitation in a Single Institution
Background: Although many studies evaluated independent prognosis factors of functional outcome in patients with subarachnoid hemorrhage (SAH) at a suitable time point, some patients take a long time to get functional improvement. The purpose of this study is to evaluate predictors for functional outcome in SAH patients who underwent surgical clipping and in-hospital rehabilitation in our single institution using Modified Rankin Scale (MRS) and Barthel Index (BI). Methods: Two-hundred fifty-one SAH patients were admitted to our hospital from January 2008 to December 2017. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 10, 2019 Category: Neurology Authors: Yushin Takemoto, Yu Hasegawa, Akihito Hashiguchi, Koichi Moroki, Hajime Tokuda, Akitake Mukasa Source Type: research

Angiographical Jaggy Sign of Remnant M2 Occlusion during Acute Mechanical Thrombectomy
In this study, we focused on the angiographical findings of remnant occlusion. Methods: Among 83 patients who underwent mechanical thrombectomy for the acute internal carotid artery or proximal middle cerebral artery (M1) occlusion, 25 patients (30%) intraoperatively exhibited the remnant M2 occlusion, in spite of the recanalization of the other M2. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 10, 2019 Category: Neurology Authors: Rei Yamaguchi, Masanori Aihara, Tatsuya Shimizu, Koji Sato, Hiroya Fujimaki, Ken Asakura, Masahiko Tosaka, Yuhei Yoshimoto Source Type: research

Transcranial Optical Monitoring of Cerebral Hemodynamics in Acute Stroke Patients during Mechanical Thrombectomy
Introduction: Mechanical thrombectomy is revolutionizing treatment of acute stroke due to large vessel occlusion (LVO). Unfortunately, use of the modified Thrombolysis in Cerebral Infarction score (mTICI) to characterize recanalization of the cerebral vasculature does not address microvascular perfusion of the distal parenchyma, nor provide more than a vascular “snapshot.” Thus, little is known about tissue-level hemodynamic consequences of LVO recanalization. Diffuse correlation spectroscopy (DCS) and diffuse optical spectroscopy (DOS) are promising methods for continuous, noninvasive, contrast-free transcrani...
Source: Journal of Stroke and Cerebrovascular Diseases - April 8, 2019 Category: Neurology Authors: Rodrigo M. Forti, Christopher G. Favilla, Jeffrey M. Cochran, Wesley B. Baker, John A. Detre, Scott E. Kasner, Michael T. Mullen, Steven R. Mess é, W. Andrew Kofke, Ramani Balu, David Kung, Bryan A. Pukenas, Neda I. Sedora-Roman, Robert W. Hurst, Omar A. Source Type: research

Left Thalamus Arteriovenous Malformation Secondary to Radiation Therapy of Original Vermian Arteriovenous Malformation: Case Report
A 70-year-old gentleman with history of hypothyroidism, hyperlipidemia, hypertension, and right superior cerebellar aneurysm presented to the neurosurgery service in 2008 with vertigo. Diagnostic cerebral angiography performed that year demonstrated a vermian arteriovenous malformations (AVM). The patient underwent stereotactic proton beam radiosurgery, which resulted in a decrease in flow and size of the lesion, and the patient was lost to follow-up. Now at the age of 80, the patient presented with acute gait instability. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 8, 2019 Category: Neurology Authors: Carlos Torres-Quinones, Matthew J. Koch, Scott B. Raymond, Aman Patel Tags: Case Report Source Type: research

Association of Hyponatremia and Risk of Short- and Long-Term Mortality in Patients with Stroke: A Systematic Review and Meta-Analysis
Hyponatremia is the most common electrolyte disorder in the clinic practice and it is closely related to the prognosis of various diseases. Studies reported that hyponatremia increased the risk of stroke mortality while yielded inconsistent findings during the follow-up period. Thus, a systematic review and meta-analysis to assess the relationship between hyponatremia and the short-term (within 90 days) and long-term (more than 1 year) prognosis of stroke patients was conducted. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 6, 2019 Category: Neurology Authors: Zhongyun Chen, Qingxia Jia, Chunyan Liu Source Type: research

Cerebral Venous Sinus Incision for Surgical Thrombectomy Combined with Thrombolysis During Decompressive Craniectomy for Malignant Cerebral Venous Sinus Thrombosis Complicated with Cerebral Hernia
This report describes an approach performed on 2 patients diagnosed with CVST combined both thrombectomy and thrombolysis with decompressive craniectomy through incising the superior sagittal sinus. The general procedure of the operation is as follows. The anterior part of the superior sagittal sinus was exposed firstly. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 5, 2019 Category: Neurology Authors: Yan'gang Wang, Yang Wang, Junjie Zhang, Shunli Du, Jiabin Wu Tags: Case Report Source Type: research

Factors Influencing Oral Intake Improvement and Feeding Tube Dependency in Patients with Poststroke Dysphagia
Objective: To assess ischemic stroke patients regarding the relationship between lesion locations, swallowing impairment, medical and demographic factors and (1) oral intake improvement and (2) feeding tube dependency at discharge from their acute hospital stay. Methods: We conducted an exploratory, retrospective observational longitudinal cohort study of acute, first-ever, ischemic stroke patients. Patients who had an initial nonoral feeding recommendation from a speech and language pathologist and who underwent a modified barium swallow study within their hospital stay were included. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 5, 2019 Category: Neurology Authors: Janina Wilmskoetter, Leonardo Bonilha, Bonnie Martin-Harris, Jordan J. Elm, Janet Horn, Heather S. Bonilha Source Type: research

Effects of capsaicin on swallowing function in stroke patients with dysphagia: A randomized controlled trial
Dysphagia is a common complication after acute stroke. While there are several innovative treatments being tested to improve the swallowing function of stroke patients with dysphagia, our aim is to explore the use of readily available natural capsaicin in stroke patients with dysphagia. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 4, 2019 Category: Neurology Authors: Zhuo Wang, Lingling Wu, Qi Fang, Meifen Shen, Lulu Zhang, Xueyun Liu Source Type: research

Systematic Review on Effectiveness of shoulder taping in Hemiplegia
Shoulder pain and subluxation are the commonly encountered problems among subjects with hemiplegia. Rehabilitating the shoulder following stroke is a challenging task among physiotherapists in rehabilitation set up. There is a need to validate the effectiveness of externally applied taping materials in hemiplegic shoulder. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 4, 2019 Category: Neurology Authors: Hariharasudhan Ravichandran, Balamurugan Janakiraman, Subramanian Sundaram, Berihu Fisseha, Tsiwaye Gebreyesus, Asmare Yitayeh Gelaw Source Type: research

Pneumonia and Risk of Serious Adverse Outcomes in Hospitalized Strokes in Thailand
Background: The impact of stroke associated pneumonia (SAP) on stroke complications is not well understood; we aimed to study the association between SAP and adverse outcomes including in-hospital mortality, prolonged length of stay and the risk of developing common serious complications (sepsis, respiratory failure, and convulsions). Methods: We retrospectively analyzed data from a cohort of 610,668 stroke patients drawn from the Universal Coverage Health Security Scheme (a national insurance database) in Thailand which covers ∼80% of the Thai population. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 4, 2019 Category: Neurology Authors: Raphae S. Barlas, Allan B. Clark, Joao H. Bettencourt-Silva, Kittisak Sawanyawisuth, Kannikar Kongbunkiat, Narongrit Kasemsap, Somsak Tiamkao, Phyo Kyaw Myint Source Type: research

The CADASIL Scale-J, A Modified Scale to Prioritize Access to Genetic Testing for Japanese CADASIL-Suspected Patients
Background: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is definitely diagnosed by genetic testing. Such testing involves the analysis of exons 2-24 of NOTCH3, which encode the epidermal growth factor-like repeat domain, where CADASIL mutations are localized. We previously reported clinical diagnostic criteria for screening CADASIL-suspected Japanese patients prior to genetic testing. Because of its high sensitivity but low specificity, most patients need to undergo genetic testing. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 4, 2019 Category: Neurology Authors: Takashi Koizumi, Ikuko Mizuta, Akiko Watanabe-Hosomi, Mao Mukai, Ai Hamano, Jun Matsuura, Tomoyuki Ohara, Toshiki Mizuno Source Type: research

The Relevance of Vascular Endothelial Growth Factor, Hypoxia Inducible Factor-1 Alpha, and Clusterin in Carotid Plaque Instability
Background: Stroke is one of the leading causes of morbidity and mortality. Thromboembolism, as a major cause of carotid artery-related stroke, can be caused by plaque rupture which is associated with neoangiogenesis within the carotid plaque. Aim: We sought to investigate a possible correlation between angiogenesis-related factors and preoperative neurological manifestations in patients with internal carotid artery stenosis, for a better understanding of thromboembolism in internal carotid artery stenosis-related stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 2, 2019 Category: Neurology Authors: Jelena Basic, Stefan Stojkovic, Afshin Assadian, Sabine Rauscher, Nikolaus Duschek, Christoph Kaun, Johann Wojta, J ürgen Falkensammer Source Type: research

Endovascular Thrombolysis or Thrombectomy for Cerebral Venous Thrombosis: Study of Nationwide Inpatient Sample 2004-2014
In this study, we analyze Nationwide Inpatient Sample (NIS) data to evaluate the safety and efficacy of endovascular therapy (ET) versus medical management in CVT. We also examined the yearly trends of ET utilization in the United States. Methods: International Classification of Diseases, Ninth Revision, Clinical Modification codes were utilized to identify CVT patients who received ET. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 2, 2019 Category: Neurology Authors: Fazeel M. Siddiqui, Matthew W. Weber, Sudeepta Dandapat, Steve Scaife, Michael Buhnerkempe, Santiago Ortega-Gutierrez, Nazan Aksan, Augusto Elias, Jonathan M. Coutinho Source Type: research

The Significance of Contrast Density of the Computed Tomography-Angiographic Spot Sign and its Correlation with Hematoma Expansion
The computed tomography angiographic (CTA) spot sign has been shown to predict hematoma expansion in patients with intracranial hemorrhage (ICH), but the significance of the spot sign density (SSD) and the spot sign ratio (SSR) has not yet been explored. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 1, 2019 Category: Neurology Authors: Omar Hussein, Khalid Sawalha, Joel Fritz, Ahmed Abd Elazim, Mohammad Hamed, Lai Wei, Shraddha Mainali Source Type: research

Leukoaraiosis Predicts Short-term Cognitive But not Motor Recovery in Ischemic Stroke Patients During Rehabilitation
Background: Leukoaraiosis has been shown to impact functional outcomes after acute ischemic stroke. However, its association with domain specific recovery after ischemic stroke is uncertain. We sought to determine whether pre-existing leukoaraiosis is associated with short-term motor and cognitive recovery after stroke. Methods: We retrospectively studied ischemic stroke patients admitted to acute inpatient rehabilitation (AIR) between January 2013 and September 2015. Patient baseline characteristics, infarct volume, prestroke modified Rankin Scale, stroke cause, rehabilitation length of stay, and Functional Independence M...
Source: Journal of Stroke and Cerebrovascular Diseases - March 30, 2019 Category: Neurology Authors: Muhib Khan, Heather Heiser, Nathan Bernicchi, Laurel Packard, Jessica L. Parker, Matthew A. Edwardson, Brian Silver, Kost V. Elisevich, Nils Henninger Source Type: research

The Effectiveness of Fluidotherapy in Poststroke Complex Regional Pain Syndrome: A Randomized Controlled Study
Objective: To evaluate whether combining fluidotherapy to conventional rehabilitation program provides additional improvements on pain severity, upper extremity functions, and edema volume in patients with poststroke complex regional pain syndrome (CRPS). Design: Randomized controlled trial. Setting: Training and research hospital. Participants: Thirty hemiplegic patients with subacute stage CRPS type-1 of the upper extremity. Interventions: The patients randomly divided into 2 groups. Both groups received a 3 week conventional rehabilitation program (5days/week, 2-4 hours/day). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - March 30, 2019 Category: Neurology Authors: Didem Sezgin Ozcan, Hilmi Umut Tatli, Cemile Sevgi Polat, Oznur Oken, Belma Fusun Koseoglu Source Type: research

Comparison of Therapeutic Ultrasound and Radial Shock Wave Therapy in the Treatment of Plantar Flexor Spasticity After Stroke: A Prospective, Single-blind, Randomized Clinical Trial
This study aimed to compare the effects of therapeutic ultrasound (US) and radial extracorporeal shock wave therapy (rESWT) in the treatment of plantar flexor spasticity after stroke. Materials and Methods: In this prospective, single-blind, randomized clinical trial, 32 patients (age range 42-78 years; male 19) with stroke were randomly divided into two groups: The US group (n  = 16) received the continuous ultrasound, intensity 1.5 w/cm2, frequency 1MHz, and duration 10 minutes. The rESWT group (n = 16) was treated with rESWT, 0.340 mJ/mm2, 2000 shots. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - March 30, 2019 Category: Neurology Authors: Hojjat Radinmehr, Noureddin Nakhostin Ansari, Soofia Naghdi, Azade Tabatabaei, Ehsan Moghimi Source Type: research

Predictors of Left Atrial Thrombi and Spontaneous Echocardiographic Contrast in the Acute Phase After Cardioembolic Stroke in Patients With Atrial Fibrillation
This study aims to investigate the utility of CHADS2 and CHA2DS2-VASc scores for predicting LAT/SEC, and to investigate the risk factors of residual LAT/SEC after CES onset. Methods: This retrospective study included 124 patients who were admitted with the acute phase of CES at our center. The clinical, echocardiographic variables, the CHADS2/CHA2DS2-VASc scores, and National Institutes of Health Stroke Scale score were retrospectively assessed on admission. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - March 29, 2019 Category: Neurology Authors: Hideyuki Kishima, Takanao Mine, Eiji Fukuhara, Kenki Ashida, Kazutaka Uchida, Shinichi Yoshimura, Masaharu Ishihara Source Type: research

Thrombolysis in Ischemic Stroke Patients with Isolate Pulmonary Arteriovenous Malformations
Pulmonary arteriovenous malformations are rare cause for ischemic stroke. British Thoracic Society Clinical Statement considered insufficient evidence of safety or clinical benefit to recommend thrombolysis for stroke with pulmonary arteriovenous malformations. For pulmonary arteriovenous malformations with hereditary hemorrhagic telangiectasia, bleeding risk after thrombolysis is high, while for isolate pulmonary arteriovenous malformations, bleeding risk is much lower. We here present 2 cases of ischemic stroke with isolate pulmonary arteriovenous malformations treated with thrombolysis. (Source: Journal of Stroke and Ce...
Source: Journal of Stroke and Cerebrovascular Diseases - March 29, 2019 Category: Neurology Authors: Gaoping Lin, Peng Jiang, Min Lou Tags: Case Report Source Type: research

Determinants Influencing the Prestroke Health Behaviors and Cardiovascular Disease Risk of Stroke Patients: A Cross-Sectional Study
Background: Knowledge about stroke and stroke prevention may provide motivation to lead a healthy lifestyle to prevent stroke. The goal of this study is to quantify the knowledge of stroke and stroke prevention of patients with a recent stroke and its association with health behaviors and cardiovascular disease risk. Methods: We conducted a prospective cross-sectional study utilizing consecutive stroke admissions at 2 hospitals in Vancouver, Canada. We included patients within 48-72hours of admission. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - March 29, 2019 Category: Neurology Authors: Beena P. Parappilly, Thalia S. Field, William B. Mortenson, Brodie M. Sakakibara, Janice J. Eng Source Type: research

Reduced Ischemic Lesion Growth with Heparin in Acute Ischemic Stroke
Objective: The role of heparin in acute ischemic stroke is controversial. We investigated the effect of heparin on ischemic lesion growth. Methods: Data were analyzed on nonthrombolyzed ischemic stroke patients in whom diffusion-weighted imaging (DWI)/perfusion-weighted imaging (PWI) MRI was performed less than 12hours of last known well and showed a PWI-DWI lesion mismatch, and who underwent follow-up neuroimaging at least 4days after admission. Lesion growth was assessed by (1) absolute lesion growth and (2) percentage mismatch lost (PML). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - March 29, 2019 Category: Neurology Authors: Eva A. Rocha, Ruijun Ji, Hakan Ay, Zixiao Li, Ethem Murat Arsava, Gisele S. Silva, Alma Gregory Sorensen, Ona Wu, Aneesh B. Singhal Source Type: research

Atrial Fibrillation: An Underestimated Cause of Ischemic Monocular Visual Loss?
Introduction: Atrial fibrillation (AF) is a major cause of ischemic stroke and Transient Ischemic Attack (TIA) and investigation for paroxysmal AF is recommended following an embolic brain event. In contrast, retinal ischemic monocular blindness is traditionally considered most linked to carotid artery disease (CAS) and investigating for AF is less vigilant. We aimed to determine the prevalence of AF in patients with ischemic monocular blindness. Methods: Consecutive records of all patients presenting to a daily TIA clinic with transient or permanent ischemic monocular blindness were reviewed, January 2014-October 2016. (S...
Source: Journal of Stroke and Cerebrovascular Diseases - March 29, 2019 Category: Neurology Authors: Angeliki Zarkali, Suk Fun Cheng, Agnes Dados, Robert Simister, Arvind Chandratheva Source Type: research

Stroke in Association with Thyroid Goitre: A Case Report
Ischaemic stroke secondary to isolated internal carotid artery thrombus without risk factors is uncommon. A 55-year-old woman presented to the acute stroke unit with acute right middle cerebral artery territory infarction secondary to right internal carotid artery occlusion. There were no risk factors for cerebrovascular disease, but mediastinal imaging showed the presence of a large retrosternal goitre which was displacing the mediastinal structures including the brachiocephalic and common carotid artery. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - March 29, 2019 Category: Neurology Authors: Linford Fernandes, Ahamad Hassan Tags: Case Report Source Type: research

Autonomic Nervous System Modifications During Wakefulness and Sleep in a Cohort of Patients with Acute Ischemic Stroke
Goal: The aims of our study were to investigate autonomic modifications in wakefulness and sleep in a cohort of patients with acute ischemic stroke and to evaluate whereas these modifications were dependent by sleep stage and stroke lateralization. Materials and Methods: We prospectively enrolled 42 patients (22 men and 20 women, mean age: 69.8 ± 11.3; range: 32-92 years) with acute ischemic stroke. All participants underwent a full-night polysomnography. As index of autonomic nervous system we used Heart Rate Variability (HRV), analyzed in wakefulness and during different sleep stages. (Source: Journal of Stroke an...
Source: Journal of Stroke and Cerebrovascular Diseases - March 29, 2019 Category: Neurology Authors: Valerio Brunetti, Catello Vollono, Elisa Testani, Fabio Pilato, Giacomo Della Marca Source Type: research

Risk Factors for Acute Heart Failure and Impact on In-Hospital Mortality after Stroke
Background: In the acute phase of stroke, some patients develop cardiac events. It could be fatal in their clinical courses. We aimed to investigate acute heart failure after stroke onset and stratify the patients by establishing a predictive model. Methods: This single-center, observational study included stroke patients diagnosed at the Department of Neurology and Neurosurgery from January 2013 to December 2014. Baseline characteristics and clinical findings on admission were analyzed for acute heart failure after stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - March 28, 2019 Category: Neurology Authors: Shogo Shima, Masaki Shinoda, Osamu Takahashi, Akihiko Unaki, Tetsuya Kimura, Yoshikazu Okada, Yasunari Niimi Source Type: research

Influence of Age Ranges on Relationship of Complex Aortic Plaque With Cervicocephalic Atherosclerosis in Ischemic Stroke
Background: Complex aortic plaque is a potential cause of acute ischemic cerebrovascular disease, which needs timely identification. Also as a marker for systemic atherosclerosis, complex aortic plaque may be indicated by significant ( ≥50%) cervicocephalic atherosclerotic stenosis. We aimed at examining whether age ranges would influence their association to more accurately estimate the risk of having complex aortic plaque in acute ischemic cerebrovascular disease. Methods: Aortic arch and cervicocephalic arteries were simultan eously evaluated using computed tomography angiography. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - March 28, 2019 Category: Neurology Authors: Qi Kong, Xin Ma, Chen Wang, Wuwei Feng, Bruce Ovbiagele, Yuren Zhang, Xiangying Du, Xianghua Fang Source Type: research

DEFENSIVE Stroke Scale: Novel Diagnostic Tool for Predicting Posterior Circulation Infarction in the Emergency Department
Background: Dizziness is the most common posterior circulation symptom; however, diagnosing a posterior circulation infarction is difficult due to a lack of typical symptoms. We aimed to investigate the frequency of misdiagnosis of a posterior circulation infarction in patients who presented with dizziness and to develop a new stroke scale that increased the diagnostic accuracy for stroke among these subjects. Methods: We retrospectively analyzed consecutive data from subjects hospitalized with ischemic stroke who presented with dizziness (the developmental phase). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - March 28, 2019 Category: Neurology Authors: Shinichiro Yamada, Keizo Yasui, Yu Kawakami, Yasuhiro Hasegawa, Masahisa Katsuno Source Type: research

The Claw Sign: An angiographic Predictor of Recanalization After Mechanical Thrombectomy for Cerebral Large Vessel Occlusion
In this study, we aimed to determine whether the presence of a claw sign was related to recanalization success after mechanical thrombectomy. Materials and Methods: We retrospectively included 73 consecutive patients treated fo r acute cerebral large vessel occlusion by mechanical thrombectomy between January 2014 and December 2017. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - March 28, 2019 Category: Neurology Authors: Yuki Yamamoto, Nobuaki Yamamoto, Yasuhisa Kanematsu, Masaaki Korai, Kenji Shimada, Yuishin Izumi, Yasushi Takagi Source Type: research

Inherited Thrombotic Thrombocytopenic Purpura Revealed by Recurrent Strokes in a Male Adult: Case Report and Literature Review
Thrombotic thrombocytopenic purpura (TTP) is a thrombotic microangiopathy related to a severe deficiency of ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeats, member 13). In this article, we describe the first case of a young male adult suffering from a hereditary TTP revealed by recurrent strokes, relapsing despite antiplatelet and anticoagulant therapy. Because of the persistent moderate thrombocytopenia, plasmatic ADAMTS13 activity was investigated and was found lower than 5% in the absence of anti-ADAMTS13 IgG. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - March 28, 2019 Category: Neurology Authors: Diane Beauvais, Laura Venditti, Olivier Chassin, B érangère Joly, Alain Ameri, Pierre Boisseau, Olivier Lambotte, Paul Coppo, Agnès Veyradier, Christian Denier Source Type: research

Spinal Cord Infarction due to Fibrocartilaginous Embolism: A Report of 3 Cases
We describe the clinical and imaging findings of FCE in 3 healthy young women with history of trivial spinal cord trauma, and recommend that FCE should be considered in the differential diagnosis of acute myelopathy. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - March 28, 2019 Category: Neurology Authors: Jeffrey N. Quinn, Hannah Breit, Rima M. Dafer Tags: Case Report Source Type: research

Social Inequality by Income in Short- and Long-Term Cause-Specific Mortality after Stroke
Goals: It is unclear whether social inequality exists for mortality after stroke. Results of studies on the relation between socioeconomic position (SEP) and mortality after stroke have been inconsistent and inconclusive. Material and Methods: We studied the association between SEP expressed by income and the risk of death after stroke by merging data on incident stroke from Danish registries with nationwide coverage. We identified all incident cases of stroke hospitalized in Denmark 2003-2012 (n  = 60503). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - March 28, 2019 Category: Neurology Authors: Klaus Kaae Andersen, Tom Skyh øj Olsen Source Type: research

Preliminary Screening Recommendations for Patients at Risk of Depression and/or Anxiety more than 1 year Poststroke
Goal: Depression and anxiety are important complications of stroke but are underdiagnosed in community settings. The current study identified which patients were at increased risk of developing either disorder more than1 year poststroke to assist in targeted screening. Methods: Crosssectional survey of 147 adults who had a stroke more than 1 year ago were recruited from stroke advocacy/support groups and an outpatient register. Participants completed the Hospital Anxiety and Depression Scale (HADS) and reported whether they had emotional problems as a stroke inpatient (single item: yes/no). (Source: Journal of Stroke and C...
Source: Journal of Stroke and Cerebrovascular Diseases - March 28, 2019 Category: Neurology Authors: David J. Unsworth, Jane L. Mathias, Diana S. Dorstyn Source Type: research

Masthead
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - March 27, 2019 Category: Neurology Source Type: research

Editorial Board
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - March 27, 2019 Category: Neurology Source Type: research

Table of Contents
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - March 27, 2019 Category: Neurology Source Type: research

Asymptomatic Intracerebral Hemorrhage May Worsen Clinical Outcomes in Acute Ischemic Stroke Patients Undergoing Thrombectomy
This study aimed to evaluate the clinical effects of AICH and its risk factors in this patient population. Methods: This observational study was based on a prospective registry study. AIS patients with large-vessel occlusion in the anterior circulation and treated with ET were recruited. During thrombectomy procedures, intra-arterial infusion of thrombolytics or antiplatelet and permanent stenting were used as remedial therapies. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - March 26, 2019 Category: Neurology Authors: Fang Jiang, Wenbo Zhao, Chuanjie Wu, Zhen Zhang, Chuanhui Li, Ruiwen Che, Jian Chen, Weiming Hu, Haiqing Song, Jiangang Duan, Xunming Ji Source Type: research