Masthead
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - May 5, 2021 Category: Neurology Source Type: research

Editorial Board
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - May 5, 2021 Category: Neurology Source Type: research

Table of Contents
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - May 5, 2021 Category: Neurology Source Type: research

Response to Letter to the Editor
This is in response to the question asked by the author of the manuscript entitled “Comments on Coronavirus Positive Patients Presenting with Stroke-Like Symptoms”. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - May 4, 2021 Category: Neurology Authors: Shaista Alam Source Type: research

Decline in rehab transfers among rehab-eligible stroke patients during the COVID-19 pandemic
: To characterize differences in disposition arrangement among rehab-eligible stroke patients at a Comprehensive Stroke Center before and during the COVID-19 pandemic. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - May 4, 2021 Category: Neurology Authors: Lauren Thau, Taylor Siegal, Mark E. Heslin, Ameena Rana, Siyuan Yu, Scott Kamen, Austin Chen, Nicholas Vigilante, Sheri Gallagher, Kevin Wegner, Jesse M. Thon, Ryna Then, Pratit Patel, Terri Yeager, Tudor G. Jovin, Rohini J. Kumar, David E. Owens, James E Source Type: research

Chronic Kidney Disease is a Risk Factor for Stroke
Chronic kidney disease (CKD) is a sustained reduction in estimated glomerular filtration rate (eGFR), and/or presence of albuminuria. People with CKD have adverse cardiovascular outcomes including stroke. CKD and stroke share several risk factors, most notably older age, diabetes and hypertension, but CKD is also an independent risk factor for stroke. Relative burden of increased risk is worse for younger people and women, with (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 26, 2021 Category: Neurology Authors: Melanie Wyld, Angela C Webster Source Type: research

Chronic and End-Stage Kidney Disease in the Neurological Intensive Care Unit
Patients with renal disease have increased rates of admission to the neurological intensive care unit related to overlapping risk factors for renal and cerebrovascular disease as well as unique risks associated with renal dysfunction alone. Management of acute neurological injury in these patients requires individualized attention to diagnostic and management factors as they relate to coagulopathy, disorders of immune function, encephalopathy and renal replacement modalities. Careful consideration of these brain-kidney interactions is necessary to optimize care for this special patient population and improve neurological a...
Source: Journal of Stroke and Cerebrovascular Diseases - April 26, 2021 Category: Neurology Authors: Sara Stern-Nezer Source Type: research

Low Levels of Klotho are Associated with Intracranial Vascular Calcification in Patients with CKD
We read with interest the article recently published by Vinters et al.1 The authors analyzed autopsy brains from patients with chronic kidney disease (CKD) and observed a high prevalence of atherosclerosis and arteriolosclerosis. In addition, the authors call attention to the severe calcification finding. Indeed, vascular calcification is a highly prevalent condition in both situations CKD2 and aging,3 and, as stated by the authors, this makes it difficult to characterize which neuropathologic feature is derived from each clinical situation. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 24, 2021 Category: Neurology Authors: Luci Carla D.B. Carvalho, Mariana P. Velozo, Venceslau A Coelho, Melani R. Custodio, Maria Aparecida Dalboni, Rosa M.A. Moys és, Rosilene M. Elias Tags: Letter to the editor Source Type: research

Re: Prognosis of Neurological Improvement in Inpatient Acute Ischemic Stroke Survivors: A Propensity Score Matching Snalysis
Wu Q and colleagues1 conducted a propensity-score (PS) matched study to identify prediction factors associated with short-term outcomes in patients with acute ischemic stroke survivors (improvement/ no improvement). In an effort to control for confounding, the authors matched on the propensity score to balance the National Institute of Health Stroke Scale (NIHSS) at admission between the two outcome groups. After matching, 92 pairs were analyzed in a multivariable outcome model of which two variables, diabetes and cognitive assessment, were identified as independent risk factors for the prognosis of neurological improvemen...
Source: Journal of Stroke and Cerebrovascular Diseases - April 22, 2021 Category: Neurology Authors: Rania A Mekary, Jiping Zhou, Tobias Kurth Tags: Letter to the Editor Source Type: research

Authors ’ Reply to: Do All Gliflozins Reduce Stroke in Patients with Type 2 Diabetes Mellitus and Impaired Renal Function?
Zhao LM et al. kindly comment on the design and the results of our recently published meta-analysis.1,2 (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 19, 2021 Category: Neurology Authors: Fotios Barkas, Evangelos Liberopoulos, Haralampos Milionis Source Type: research

Do all gliflozins reduce stroke in patients with type 2 diabetes mellitus and impaired renal function?
We have read with great interest a study of meta-analysis1 recently published in Journal of Stroke and Cerebrovascular Diseases. In that study1 Barkas and colleagues drew their main conclusion that sodium-glucose transporter 2 (SGLT2) inhibitors reduce the risk of total stroke in patients with type 2 diabetes mellitus (T2DM) and impaired renal function (IRF), which was based on the result of meta-analysis on the outcome of total stroke (including ischemic and hemorrhagic stroke) in the subgroup of patients with T2DM and IRF (Fig. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 17, 2021 Category: Neurology Authors: Li-Min Zhao, Liang-Liang Ding, Ze-Lin Zhan, Mei Qiu Tags: Letter to the Editor Source Type: research

Use of Pulmonary Computed Tomography for Evaluating Suspected Stroke-Associated Pneumonia
Accurate and timely diagnosis of pneumonia complicating stroke remains challenging and the diagnostic accuracy of chest X-ray (CXR) in the setting of stroke-associated pneumonia (SAP) is uncertain. The overall objective of this study was to evaluate the use of pulmonary computed tomography (CT) in diagnosis of suspected SAP. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 16, 2021 Category: Neurology Authors: Amit K. Kishore, Anand Devaraj, Andy Vail, Kirsty Ward, Philip G. Thomas, Dwaipayan Sen, Alex Procter, Maychaw Win, Natasha James, Christine Roffe, Andreas Meisel, Mark Woodhead, Craig J. Smith Source Type: research

An Enriched Environment Leads to Increased Synaptic Plasticity-Associated miRNA Levels after Experimental Subarachnoid Hemorrhage
Subarachnoid hemorrhage is a type of stroke caused by usually bleeding in the subarachnoid space with high morbidity and mortality.1,2 The cause is usually arterial aneurysm rupture and arterial hypertension. SAH also affects cognitive functions. Half of the patients may return to their daily lives in a year after SAH, but most of these patients often have problems in memory, executive functions, and speech functions in the future.3 Although long-term neurological disorders are thought to be caused by late-term cerebral ischemia due to vasospasm triggered by extravascular blood contact with the arteries, the molecular basi...
Source: Journal of Stroke and Cerebrovascular Diseases - April 15, 2021 Category: Neurology Authors: Fulya Buge Ergen, Didem Turgut Cosan, Turan Kandemir, İlknur Dag, Fezan Mutlu, Tevfik Erhan Cosan Source Type: research

Intravenous tPA Delays Door-To-Puncture Time in Acute Ischemic Stroke with Large Vessel Occlusion
Although intravenous thrombolysis (IVT) is recommended among acute ischemic stroke (AIS) patients secondary to large vessel occlusion (LVO) undergoing mechanical thrombectomy (MT), time delays with bridging therapy (IVT prior to MT) and its potential benefit remains unclear. We compared the time delays and clinical outcomes among AIS SECONDARY TO LVO patients treated with bridging therapy or direct MT (dMT) at a comprehensive stroke center (CSC). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 14, 2021 Category: Neurology Authors: Kunakorn Atchaneeyasakul, Shashvat Desai, Konark Malhotra, Jaydevsinh Dolia, Kavit Shah, Jeffrey L. Saver, Tudor Jovin, Ashutosh P. Jadhav Source Type: research

Clinical and Demographic Factors Influence Clinical Trial Enrollment
Clinical trial screening is a key siphon point in the clinical research pipeline, with biases in this step potentially informing treatment indications, medication outcomes, and overall generalizability of data to a population at large.1 Addressing clinical trial enrollment is a crucial step towards equity in medicine.2,3 Enrollment biases have been identified in stroke clinical trials previously, including enrolling larger strokes with higher NIHSS scores in Endovascular trials, underrepresentation of women, and missing NIHSS documentation in stroke registries. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 14, 2021 Category: Neurology Authors: Daniel J. Suto, Emily Perrinez, Karen S. Rapp, Mohammed Nabulsi, Thomas M. Hemmen Source Type: research

Failure of Anticoagulation to Prevent Stroke in Context of Lupus-Associated Anti-Phospholipid Syndrome and Mild COVID-19
We present a 43-year-old female with a history of seropositive-antiphospholipid syndrome and systemic lupus erythematosus who developed an acute ischemic stroke in the setting of mild COVID-19 infection despite adherence to chronic systemic anticoagulation. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 12, 2021 Category: Neurology Authors: Keith J. Kincaid, Alexis N. Simpkins Source Type: research

COVID-19 Associated Reversible Cerebral Vasoconstriction Syndrome Successfully Treated with Nimodipine and Aspirin
A 31-year-old sexually active, non-smoker female with a past medical history of spina-bifida and idiopathic thoracolumbar scoliosis status post hardware spinal fusion surgery five years ago presented with a one-day history of severe holocranial headaches associated with nausea and visual changes. A thorough neurological examination was intact. She complained of mild cough as well. She had a positive nasopharyngeal swab for SARS-CoV-2 on RT-PCR assay. A comprehensive drug screen including amphetamines, cocaine, nicotine, alcohol, and ecstasy as well as a pregnancy test were negative; coagulation profile was within normal li...
Source: Journal of Stroke and Cerebrovascular Diseases - April 12, 2021 Category: Neurology Authors: Tarab Mansoor, Ali A. Alsarah, Hossein Mousavi, Javed Elyias, Tarun Girotra, Omar Hussein Tags: Case Report Source Type: research

Detection of Myocardial Infarction by Cardiac Magnetic Resonance in Embolic Stroke Related to First Diagnosed Atrial Fibrillation
Elevated troponin levels are found in a significant number of patients who are diagnosed with acute embolic stroke (AES) after first diagnosed atrial fibrillation (AF). These myocardial injuries, which are known as cardiocerebral infarction (CCI), are potentially caused by coronary embolism and correspond to simultaneous cardiac and cerebral embolisms. However, this severe condition remains poorly understood. In this prospective study, we aimed to investigate the prevalence and the cardiac magnetic resonance (CMR) characteristics of CCI. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 10, 2021 Category: Neurology Authors: Adrien Artus, Romain Didier, Margaux Blain, Pierre Comby, Thibault Leclercq, Hugo Debeaumarch é, Frédéric Ricolfi, Marianne Zeller, Yannick Bejot, Alexandre Cochet, Yves Cottin Source Type: research

Constraint Induced Movement Therapy Increases Functionality and Quality of Life after Stroke
The paretic and spastic brachial condition causes the learned non-use, also known as disuse; the individual expresses difficulty in using the compromised upper limb and develops compensatory mechanisms that prioritize the use of only the unaffected extremity, triggering the poor adaptation of neuroplasticity, which is the ability to recover a nerve function through behavior change strategies.25,35 (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 10, 2021 Category: Neurology Authors: Larissa Salgado Oliveira Rocha, Geisa Crissy Bandeira Gama, Rodrigo Santiago Barbosa Rocha, Let ícia de Barros Rocha, Caroline Prudente Dias, Luciane Lobato Sobral Santos, Márcio Clementino de Souza Santos, Maria Imaculada de Lima Montebelo, Rosana Mach Source Type: research

Small Interfering RNA Targeting DMP1 Protects Mice Against Blood-Brain Barrier Disruption and Brain Injury After Intracerebral Hemorrhage
This study aimed to investigate the expression pattern of DMP1 in the mouse brain and explore the role of DMP1 in BBB disruption and brain injury in a mouse model of ICH. Mice were subjected to autologous blood injection-induced ICH. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 9, 2021 Category: Neurology Authors: Yue Shu, Juan Huang, Meng Gao, Shengwei Gan, Shujuan Zhu, Shiye Xu, Zhengyu Yang, Yuhui Liao, Weitian Lu Source Type: research

Falls After Stroke: A Follow-up after Ten Years in Lund Stroke Register
To evaluate incidence of self-reported falls and associated factors in a ten-year perspective after stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 8, 2021 Category: Neurology Authors: Ann-Cathrin J önsson, Ingrid Lindgren, Hossein Delavaran, Bo Norrving, Arne Lindgren Source Type: research

Changes in Procoagulant Blood Biomarkers After Mechanical Thrombectomy
We report changes in blood coagulation markers after MT treated with and without tissue plasminogen activator for AIS. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 8, 2021 Category: Neurology Authors: Jonathan C. Welch, Kadir Erkmen, Nina Gentile Source Type: research

Endovascular Treatment of Infective Endocarditis-Related Acute Large Vessel Occlusion Stroke
Embolic stroke is a frequent complication of infective endocarditis yet lacks acute treatment as intravenous thrombolysis should be avoided due to high risk of intracerebral hemorrhage. Mechanical thrombectomy for large vessel occlusion may be a promising treatment but there is limited data on safety outcomes in infective endocarditis. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 8, 2021 Category: Neurology Authors: Elie Sader, Mohamad Abdalkader, Natalie Thom, Thanh N. Nguyen, Sandra McDonald, David Greer, Stacy C. Brown, Alaa Mohamedali, Jose Gutierrez, Hang Shi, Jane Morris, Victor Lopez-Rivera, Sunil A. Sheth, Kelly L. Sloane, Aneesh Singhal, Kunakorn Atchaneeyas Source Type: research

Inversion of T Waves on Admission is Associated with Mortality in Spontaneous Intracerebral Hemorrhage
Cardiac dysfunction directly caused by spontaneous intracerebral hemorrhage (ICH) is a poorly understood phenomenon, and its impact on outcome is still uncertain. The aim of this study is to investigate the relationship between electrocardiographic (EKG) abnormalities and mortality in ICH. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 8, 2021 Category: Neurology Authors: Andrea Loggini, Ali Mansour, Faten El Ammar, Ruth Tangonan, Christopher L. Kramer, Fernando D. Goldenberg, Christos Lazaridis Source Type: research

Effect of Rhythm of Music Therapy on Gait in Patients with Stroke: Several Questions
This study is a valuable and interesting article but we have several queries about this article. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 8, 2021 Category: Neurology Authors: Lei Chen, Lan Chen, Weina Tang Tags: Letter to the Editor Source Type: research

Telestroke Across the Continuum of Care: Lessons from the COVID-19 Pandemic
While use of telemedicine to guide emergent treatment of ischemic stroke is well established, the COVID-19 pandemic motivated the rapid expansion of care via telemedicine to provide consistent care while reducing patient and provider exposure and preserving personal protective equipment. Temporary changes in re-imbursement, inclusion of home office and patient home environments, and increased access to telehealth technologies by patients, health care staff and health care facilities were key to provide an environment for creative and consistent high-quality stroke care. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 8, 2021 Category: Neurology Authors: Amy K. Guzik, Sheryl Martin-Schild, Prasanna Tadi, Sherita N. Chapman, Sami Al Kasab, Sharyl R. Martini, Brett C. Meyer, Bart M. Demaerschalk, Marcella A. Wozniak, Andrew M. Southerland Source Type: research

Masthead
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 7, 2021 Category: Neurology Source Type: research

Editorial Board
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 7, 2021 Category: Neurology Source Type: research

Table of Contents
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 7, 2021 Category: Neurology Source Type: research

Mean Platelet Volume is a Prognostic Marker in Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis
There is conflicting data regarding the association between platelet parameters and prognosis of stroke patients treated with intravenous thrombolysis. We aimed to analyze this association in a cohort of patients treated with rtPA. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 7, 2021 Category: Neurology Authors: Filipa Dourado Sotero, Alexandre Cal çada, Diana Aguiar de Sousa, Mariana Dias, Ana Catarina Fonseca, Teresa Pinho e Melo, Patrícia Canhão Source Type: research

Dietary Oily Fish Intake is Inversely Associated with Severity of White Matter Hyperintensities of Presumed Vascular Origin. A Population-Based Study in Frequent Fish Consumers of Amerindian Ancestry
Oily fish is a major dietary source of omega-3 polyunsaturated fatty acids and other nutrients that may reduce the expression of cerebral small vessel disease (cSVD) biomarkers, including white matter hyperintensities (WMH) of presumed vascular origin. However, information on this relationship is limited. We aimed to assess the association between oily fish intake and WMH severity in a population of frequent fish consumers. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 7, 2021 Category: Neurology Authors: Oscar H. Del Brutto, Bettsy Y. Recalde, Robertino M. Mera Source Type: research

Outcomes of COVID-19 complications and their possibilities as potential triggers of stroke
The coronavirus disease 2019 (COVID-19) has been a pandemic like no other seen in our times. It has impacted the entire globe affecting more than 180 countries with 81.9 million cases and 1.7 million deaths as of December 29, 20201. Unlike other virus-related spread, COVID-19 since its early days is known to have a high infection rate as well as high mortality, which in turn has resulted in such a devastating impact across the world. The mortality rates among hospitalized patients with COVID-19 infection without stroke range from 22% to 45%2,3, but the mortality was very high (38%) in stroke patients with COVID-19 infectio...
Source: Journal of Stroke and Cerebrovascular Diseases - April 7, 2021 Category: Neurology Authors: Urvish Patel, Preeti Malik, Deep Mehta, Priyanka Rajput, Mashu Shrivastava, Madiha Naveed, Eseosa Urhoghide, Mehwish Martin, Shamima Somi, Richa Jaiswal, Achint Patel, Avantika Israni, Jagmeet Singh, Asim Kichloo, Shamik Shah, Abhishek Lunagariya Source Type: research

International survey of Mechanical Thrombectomy Stroke systems of care during COVID-19 pandemic
The COVID-19 pandemic has strained the healthcare systems across the world but its impact on acute stroke care is just being elucidated. We hypothesized a major global impact of COVID-19 not only on stroke volumes but also on various aspects of thrombectomy systems. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 6, 2021 Category: Neurology Authors: Dileep R Yavagal, Vasu Saini, Violiza Inoa, Hannah E Gardener, Sheila O Martins, Manav Fakey, Santiago Ortega, Ossama Mansour, Thomas Leung, Ashutosh P Jadhav, Jennifer Potter-Vig, Anurag Mairal, Miao Zhongrong, P.N. Sylaja, Andrew M Demchuk, MT2020 Globa Source Type: research

Wall Redness of Enlarged Unruptured Cerebral Aneurysm
This study aimed to evaluate the EUCA wall redness based on quantitative signal intensity method and to compare the clinical and radiological characteristics between EUCA and non-EUCA. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 5, 2021 Category: Neurology Authors: Hidetoshi Matsukawa, Yoichiro Nagao, Manabu Shirakawa, Kazutaka Uchida, Shinichi Yoshimura Source Type: research

White Matter Hyperintensity and Cardiovascular Disease Outcomes in the SPRINT MIND Trial
The Systolic Blood Pressure Intervention Trial (SPRINT) randomized patients to a goal systolic blood pressure (SBP) (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 3, 2021 Category: Neurology Authors: Nazanin Sheibani, Ka-Ho Wong, Tanya N. Turan, Sharon D. Yeatts, Rebecca F. Gottesman, Shyam Prabhakaran, Natalia S. Rost, Adam de Havenon Source Type: research

Safety of Ticagrelor in Moderate and Severe Acute Ischemic Stroke: A Single-Center Retrospective Review
Ticagrelor is a potent P2Y12 receptor antagonist that may have a role in acute ischemic stroke (AIS), particularly in patients with symptomatic atherosclerotic disease.1,2 Recently, a large randomized control trial demonstrated a significant reduction in stroke or death within 30 days following minor stroke or TIA with ticagrelor plus aspirin versus aspirin alone.3 Studies of ticagrelor have focused on patients with minor stroke or TIA; however, safety of ticagrelor following more severe ischemic strokes is unknown. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 3, 2021 Category: Neurology Authors: Stephen W. English, David R. Landzberg, Nirav R. Bhatt, Michael R. Frankel, Digvijaya Navalkele Source Type: research

Consideration Needed for early Anticoagulation Following Intravenous tPA in Patients with COVID-19
We read the article by Carneiro et al with great interest.1 We have similar experiences at two downtown Los Angeles certified stroke centers with the use of intravenous tPA. However, there are concerning observations lately among COVID-19 patients who developed large vessel re-occlusions shortly after their original stroke symptoms were aborted by intravenous tPA. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 2, 2021 Category: Neurology Authors: Angelo Jimenez, Arvind Ravinutala, Jonathan Eskenazi, Prissilla Xu, Antonio Liu Tags: Letter to the Editor Source Type: research

Letter to Editor: Consideration Needed for Early Anticoagulation Following Intravenous tPA in Patients with COVID-19
We read the article by Carneiro et al with great interest1. We have similar experiences at two downtown Los Angeles certified stroke centers with the use of intravenous tPA. However, there are concerning observations lately among COVID-19 patients who developed large vessel re-occlusions shortly after their original stroke symptoms were aborted by intravenous tPA. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 2, 2021 Category: Neurology Authors: Angelo Jimenez, Arvind Ravinutala, Jonathan Eskenazi, Prissilla Xu, Antonio Liu Source Type: research

Ischemic Cerebellar Stroke in a 4-Year-Old Boy After Chickenpox: An Atypical Vascular Involvement
We describe a pediatric case of post-varicella cerebellar stroke due to basilar artery involvement. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 1, 2021 Category: Neurology Authors: Patr ícia Marques, Cristina Pereira, Fernando Silva, Teresa Garcia, Joana A. Ribeiro Tags: Case Report Source Type: research

Clinical and Genetic Heterogeneity in a Large Family with Pseudoxanthoma Elasticum: MTHFR and SERPINE1 Variants as Possible Disease Modifiers in Developing Ischemic Stroke
Pseudoxanthoma elasticum (PXE) is a rare autosomal recessive disorder caused by pathogenic variants in the ABCC6 gene. The phenotypic spectrum of PXE is highly variable and includes principally three major features: skin lesions, eye and vascular manifestations, while brain manifestations are less common. To date about 400 different PXE associated variants in ABCC6 gene are described without any evident genotype –phenotype correlation. Herein, we report the clinical and molecular findings of a large PXE family with clinical and genetic intra-familial variability with significant cerebrovascular involvement. (Source: ...
Source: Journal of Stroke and Cerebrovascular Diseases - April 1, 2021 Category: Neurology Authors: Giorgia Bruno, Marco Ritelli, Andrea Di Pietro, Lorenzo Cipriano, Marina Colombi, Giacomo Lus, Gianfranco Puoti Source Type: research

“Eye” Don't See: An Analysis of Visual Symptom Reporting by Stroke Survivors from a Large Epidemiology Study
The purpose was to explore the reported symptoms of post-stroke visual impairment from a large multi-centre prospective epidemiology study. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 1, 2021 Category: Neurology Authors: Lauren R Hepworth, Claire Howard, Kerry L Hanna, Jim Currie, Fiona J Rowe Source Type: research

Study Protocol for a Randomized, Double-Blind, Placebo-Controlled, Phase-II Trial: AdrenoMedullin for Ischemic Stroke Study
Acute ischemic stroke (IS) is a devastating disorder closely linking to severe disabilities and poor quality of life. Currently, the only approved treatments are antiplatelet agents and reperfusion therapies; identifying other therapeutic options is necessary and urgent.1 After the onset of blood vessel occlusion, ischemic injury triggers inflammatory cascades in the parenchyma that further amplify tissue damage,2,3 implying the necessity of anti-inflammatory treatment from the very acute phase of IS. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 1, 2021 Category: Neurology Authors: Takeshi Yoshimoto, Satoshi Saito, Katsuhiro Omae, Yorito Hattori, Kazuki Fukuma, Kazuo Kitamura, Ryosuke Kakuta, Toshihiro Kita, Hirofumi Maruyama, Haruko Yamamoto, Masafumi Ihara Source Type: research

Non-Coding RNAs as Circulating Biomarkers for the Diagnosis of Intracranial Aneurysm: A Systematic Review and Meta-Analysis
Early diagnosis of intracranial aneurysm (IA) is arduous in the current situation, and no biomarker is available for the screening of IA. We here systematically evaluate the diagnostic value of circulating non-coding RNA (ncRNA) for the diagnosis of IA. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 1, 2021 Category: Neurology Authors: Yuehui Wu, Jin Zheng, Yun Sun, Xuan Wang, Hongyang Zhao, Feng Qiu, Shuyuan Zhang, Xiaobing Jiang, Xinyu Yu Source Type: research

Protocatechuic Acid Suppresses Microglia Activation and Facilitates M1 to M2 Phenotype Switching in Intracerebral Hemorrhage Mice
Microglia activation, a key process in secondary injury following intracerebral hemorrhage (ICH), is divided to M1 and M2 phenotype. Protocatechuic acid (PCA) is a phenolic acid been proved neuroprotection in ICH without understanding of details. Thus, this study aimed to observe the influence of PCA on microglia activation and explore underlying mechanisms. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 1, 2021 Category: Neurology Authors: Zhiyu Xi, Canxin Xu, Xiao Chen, Baofeng Wang, Zhihong Zhong, Qingfang Sun, Yuhao Sun, Liuguan Bian Source Type: research

Cerebral Venous Thrombosis in Sub-Saharan Africa: A Systematic Review
The global clinical epidemiology of cerebral venous thrombosis (CVT) is well described in high-income countries1,2 and in some middle-income countries, where hospital-based case series,3,4 suggest that the frequency of CVT is probably higher than in high-income countries. The clinical epidemiology of CVT in World zones composed predominantly by low-income countries, such as Sub-Saharan Africa, is almost unknown. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - March 31, 2021 Category: Neurology Authors: Yanina Baduro, Jos é M Ferro Source Type: research

Non-Dolichoectatic Vertebral Artery Compression of the Medulla: A Comprehensive Literature Review
This article presents the largest literature review to date on medullary compression of the vertebral arteries. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - March 31, 2021 Category: Neurology Authors: Cameron John Sabet Source Type: research

Detection of Early Vascular Atherosclerosis in Type 2 Diabetes Mellitus Using Ultrasound Radiofrequency-Data Technique
To quantitatively evaluate changes in vascular elasticity and intima-media thickness (IMT) of the common carotid artery (CCA) with Ultrasound radiofrequency (RF)-data technology in asymptomatic patients with type-2 diabetes mellitus (T2DM) and controls. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - March 31, 2021 Category: Neurology Authors: Hai-Jun Dan, Hong Ji, Ya-Qing Zhou, Cai-Ying Li, Bu-Lang Gao Source Type: research

Response to the Letter to the Editor: Consideration Needed for Early Anticoagulation Following Intravenous tPA in Patients with COVID-19
We thank Dr. Angelo Jimenez and his colleagues for their letter to the editor regarding our report of a multicenter series of patients with coronavirus disease 2019 (COVID-19) who received intravenous (IV) tissue plasminogen activator (tPA) for suspected acute ischemic stroke. Their letter emphasizes the important contribution of a hypercoagulable state in patients with COVID-19. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - March 29, 2021 Category: Neurology Authors: Thiago Carneiro, Jonathan Dashkoff, Lester Leung, Christa O'Hana S. Nobleza, Erika Marulanda-Londono, Mausaminben Hathidara, Sebastian Koch, Nicole Sur, Alexandra Boske, Barbara Voetsch, Ali Daneshmand, Julie Shulman, Giaocchino Curiale, David M. Greer, J Source Type: research

A1 Segment Unruptured Aneurysm of Persistent Primitive Olfactory Artery Coexisted with Accessory Middle Cerebral Artery
A persistent primitive olfactory artery (PPOA) is a rare anomaly for the anterior cerebral artery (ACA), which generally arises from the internal carotid artery, runs along the olfactory tract, and makes a hairpin bend to supply the territory of the distal ACA. 1 –6 This anomalous artery is often associated with cerebral aneurysms. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - March 28, 2021 Category: Neurology Authors: Yuka Ogawa, Kosuke Soejima, Ichiro Kawahara, Eri Shiozaki, Yoichi Morofuji, Tomonori Ono, Wataru Haraguchi, Keisuke Tsutsumi Tags: Case Report Source Type: research

Utility of Magnetic Resonance Spectroscopy for the Progression of Neurological Symptoms in Lenticulostriate Artery Territory Infarction
The present study aimed to examine the effectiveness of proton magnetic resonance spectroscopy (1HMRS) in determining the progression of neurological symptoms resulting in acute ischemic stroke in patients with lenticulostriate artery (LSA) infarction. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - March 27, 2021 Category: Neurology Authors: Yuji Shiga, Tomohisa Nezu, Masahiro Nakamori, Naohisa Hosomi, Yuji Akiyama, Keisuke Tachiyama, Teppei Kamimura, Naoto Kinoshita, Yuki Hayashi, Hayato Matsushima, Eiji Imamura, Shiro Aoki, Hiroki Ueno, Tomohiko Ohshita, Shinichi Wakabayashi, Fumiyuki Yamas Source Type: research