Bilateral Cerebral Hyperperfusion Syndrome Following Carotid Artery Stenting in Stroke – A Case Report
Revascularization of the symptomatic carotid artery is performed with endarterectomy or stenting. Rarely, patients may develop cerebral hyperperfusion syndrome (CHS) following revascularization. This usually occurs in the cerebral hemisphere ipsilateral to revascularized carotid stenosis. CHS rarely involves the contralateral hemisphere. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 15, 2020 Category: Neurology Authors: Nandakumar Nagaraja, Manuel Viamonte, Jun Yu, Stephen C. Rohrbough Jr, Anna Y. Khanna Tags: Case Report Source Type: research

Prognostic Significance of Stroke-Associated Infection and other Readily Available Parameters in Acute Ischemic Stroke Treated by Intravenous Thrombolysis
The impact of contracting stroke-associate infection (SAI) that requires antibiotic treatment after an acute ischemic stroke (AIS) treated with alteplase remains unclear. We studied the profiles of SAI in patients with AIS treated with alteplase toward identifying predictive factors and prognostic implications at 90 days post-stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 15, 2020 Category: Neurology Authors: Justyna Derbisz, Klaudia Nowak, Marcin Wnuk, Roman Pulyk, Jeremiasz Jagiella, Joanna Slowik, Tomasz Dziedzic, Agnieszka Slowik Source Type: research

Letter to the editor regarding “clinical prediction of surgical revascularization outcome in moyamoya disease via transcranial color sonography”
We read with great interest the article by Pan et  al.1 entitled “Clinical Prediction of Surgical Revascularization Outcome in Moyamoya Disease Via Transcranial Color Sonography” recently published in Journal of Stroke and Cerebrovascular Diseases. We really appreciate the interesting observation of their conclusions. Nevertheless, after readi ng this article, we would like to highlight two questions that it raises. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 15, 2020 Category: Neurology Authors: Shuai Zheng, Peicong Ge, Wen He Tags: Letter to the Editor Source Type: research

Stroke as a Neurological Complication of COVID-19: A Systematic Review and Meta-analysis of Incidence, Outcomes and Predictors
COVID-19 is a multi-system infection which predominantly affects the respiratory system, but also causes systemic inflammation, endothelialitis and thrombosis. The consequences of this include renal dysfunction, hepatitis and stroke. In this systematic review, we aimed to evaluate the epidemiology, clinical course, and outcomes of patients who suffer from stroke as a complication of COVID-19. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 15, 2020 Category: Neurology Authors: Isabel Siow, Keng Siang Lee, John J.Y. Zhang, Seyed Ehsan Saffari, Adeline Ng, Barnaby Young Source Type: research

Insights Into Direct Oral Anticoagulant Therapy Implementation of Stroke Survivors with Atrial Fibrillation in an Ambulatory Setting
Atrial fibrillation (AF) is the most common cardiac arrhythmia and increases the risk of ischemic stroke by about five times.1 Oral anticoagulation (OAC) with direct oral anticoagulants (DOAC) or vitamin K antagonists (VKA) reduces ischemic stroke risk in AF patients. Currently, DOAC (apixaban, dabigatran, edoxaban and rivaroxaban) are recommended as first-line treatment for stroke prevention in AF patients.2 Despite several advantages compared to VKA, DOAC have a short half-life of about 12 h. Missing more than 5% of intakes is associated with a higher occurrence of thromboembolic events in OAC-treated AF patients. (Sourc...
Source: Journal of Stroke and Cerebrovascular Diseases - December 14, 2020 Category: Neurology Authors: Valerie Albert, Alexandros A. Polymeris, Fine Dietrich, Stefan T. Engelter, Kurt E. Hersberger, Sabine Schaedelin, Philippe A. Lyrer, Isabelle Arnet Source Type: research

Chronic Kidney Disease and Cognitive Impairment
Chronic kidney disease (CKD) is associated with a high risk of cognitive impairment (CI). Both vascular and metabolic factors are implicated in the causation of CI in CKD. The traditional risk factors for CI are more prevalent in CKD and interact reciprocally. CI in CKD is associated with reduced functional capacity, poor quality of life and mortality. Cognition declines significantly after initiation of haemodialysis (HD). Repeated cerebral insults related to intra-dialytic haemodynamic instability may be responsible for the rapid, step-wise decline in cognition observed in HD patients. (Source: Journal of Stroke and Cere...
Source: Journal of Stroke and Cerebrovascular Diseases - December 12, 2020 Category: Neurology Authors: Asam Murtaza, Indranil Dasgupta Source Type: research

Functional Outcome After Mechanical Thrombectomy with or without Previous Thrombolysis
Combined intravenous therapy (IVT) and mechanical thrombectomy (MT) is the standard treatment for acute ischemic stroke (AIS) with large vessel occlusion (LVO). However, the use of   IVT before MT is recently being questioned. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 11, 2020 Category: Neurology Authors: Manuel Machado, Marta Alves, Alberto Fior, Isabel Fragata, Ana Lu ísa Papoila, João Reis, Ana Paiva Nunes Source Type: research

Stroke Thrombolysis in Patients Taking Ticagrelor –Two Successful Cases and a Review of the Literature
Ticagrelor is a novel antiplatelet agent that is frequently used for secondary prevention in coronary artery disease and has emerging evidence in stroke after the recent results of SOCRATES and THALES trials. The use of intravenous thrombolysis with alteplase in acute ischemic stroke (AIS) patients on ticagrelor is a topic of debate as the safety profile of ticagrelor in this setting is not well established. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 11, 2020 Category: Neurology Authors: David R. Landzberg, Stephen English, Michael Frankel, Digvijaya Navalkele Source Type: research

Management of Acute Central Retinal Artery Occlusion, a “Retinal Stroke”: An Institutional Series and Literature Review
Acute central retinal artery occlusion (CRAO) is an ophthalmologic emergency that often results in permanent vision loss. Over 25% are associated with acute cerebral ischemia. In the absence of existing Level I treatment options, this study aims to examine institutional practice patterns and review the literature to develop a formalized approach to the treatment of CRAO in the era of ischemic stroke protocols. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 11, 2020 Category: Neurology Authors: Katriel E. Lee, Christine Tschoe, Stephanie A. Coffman, Carol Kittel, Patrick A. Brown, Quang Vu, Kyle M. Fargen, Bartlett H. Hayes, Stacey Q. Wolfe Source Type: research

Effects of Different Degrees of Carotid Artery Stenosis on the Expression of XIAP and Smac in the Ischemic Penumbra of Rats with Cerebral Ischemia-Reperfusion
To investigate the effects of different degrees of carotid artery stenosis (CAS) on the expression of XIAP and Smac in ischemic penumbra of rats with cerebral ischemia-reperfusion (I/R). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 10, 2020 Category: Neurology Authors: Ru-Ping Xiang, Mei-Jun Zhou, Rong Cui, Hui-Yun Yu, Qiong Chen, Yu-Juan Huang, Zhi Li, Cheng Yu Source Type: research

Intraventricular Silicone Oil Migration Resembling Hemorrhagic Complication in a Patient with Ischemic Stroke Receiving Antithrombotic Therapy
We report herein a case of intraventricular silicone oil migration, a rare complication of intraocular silicone oil tamponade, mimicking a hemorrhage during antithrombotic therapy for ischemic stroke. A 62-year-old male patient with a history of diabetic retinopathy was admitted for right hemiparesis and dysarthria. Brain magnetic resonance imaging on admission showed an acute left-sided ventral medullary infarction, and antithrombotic therapy was started. Head computed tomography done on the next day after admission showed an area of high-density resembling a hematoma in the lateral ventricle. (Source: Journal of Stroke a...
Source: Journal of Stroke and Cerebrovascular Diseases - December 10, 2020 Category: Neurology Authors: Rui Shimazaki, Marie Tsunogae, Masayuki Ueda Tags: Case report Source Type: research

Masthead
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 9, 2020 Category: Neurology Source Type: research

Editorial Board
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 9, 2020 Category: Neurology Source Type: research

Table of Contents
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 9, 2020 Category: Neurology Source Type: research

Influence of Psychological Disorders on the Functional Outcomes in the Survivors of Ischemic Stroke
In this study we decided to find out the frequency of psychological disorders and its association with impairment of daily living. We assessed the association of psychological symptoms after stroke and study their impact on physical functional recovery. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 9, 2020 Category: Neurology Authors: Dr. Gunjan Badwaik, Palash Badwaik Source Type: research

Antiplatelet Therapy During Emergent Extracranial Internal Carotid Artery Stenting: Comparison of Three Intravenous Antiplatelet Perioperative Strategies
Guidelines for antiplatelet therapy administration, during emergent stenting for extra-cranial internal carotid artery (EC-ICA) occlusion in the setting of acute ischemic stroke (AIS) are lacking. Different antiplatelet regimen are used in association to endovascular therapy (EVT) for the treatment of EC-ICA lesions. We aimed to compare the clinical and radiological effects of three intravenous antiplatelet agents used during emergent EC-ICA stenting. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 9, 2020 Category: Neurology Authors: Fran çois Delvoye, Benjamin Maier, Simon Escalard, Julien Labreuche, Laurie-Anne Thion, Soufiane Aknouche, Solène Hebert, Hocine Redjem, Stanislas Smajda, Gabriele Ciccio, Julien Allard, Candice Sabben, Michael Obadia, Alain Maertens de Noordhout, Jean- Source Type: research

Measuring the Optic Nerve Sheath Diameter with Ultrasound in Acute Middle Cerebral Artery Stroke Patients
Measurement of the optic nerve sheath diameter (ONSD) with ultrasound enables non-invasive and indirect assessment of increased intracranial pressure (ICP). Although most of the studies were employed with traumatic brain injury patients, it's increasingly popular in acute ischemic stroke (AIS) studies. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 9, 2020 Category: Neurology Authors: Seda G üzeldağ, Gökhan Yılmaz, Merva Tuna, Mükerrem Altuntaş, Mustafa Özdemir Source Type: research

White Matter Hypoperfusion Associated with Leukoaraiosis Predicts Intracranial Hemorrhage after Intravenous Thrombolysis
White matter hyperintensity is common in patients receiving intravenous thrombolysis. Some studies have expressed concern about the increased risk of hemorrhagic transformation and poor prognosis for those patients with pre-existing leukoaraiosis. The purpose of this study was to evaluate hypoperfusion associated with leukoaraiosis before thrombolysis using CT perfusion and to explore whether chronic white matter hypoperfusion increases risks of intracranial hemorrhage and poor clinical prognosis. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 9, 2020 Category: Neurology Authors: Fengzhen Qiu, Cuiping Chen, Zijian Fan, Jiayou Qiu, Qitao Chen, Bei Shao Source Type: research

Corrigendum to ‘Benefits and Safety of Periprocedural Heparin During Thrombectomy in Patients Contra-Indicated for Alteplase’ [Journal of Stroke and Cerebrovascular Diseases, Vol. 29, No. 10 (October), 2020: 105052]
The authors regret to have forgotten two main authors of the text, Pr Benjamin GORY and Pr Sebastien RICHARD who actively participated with the database of the ETIS Registry and for instance helped in the elaboration of this study. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 9, 2020 Category: Neurology Authors: Sol ène Hebert, Pierre Clavel, Benjamin Maier, Katsuhiro Mizutani, François Delvoye, Bertrand Lapergue, Malek Ben Maacha, Robert Fahed, Simon Escalard, Jean-Philippe Desilles, Hocine Redjem, Gabriele Ciccio, Stanislas Smajda, Benjamin Gory, Sébastien R Tags: Corrigendum Source Type: research

Impact of COVID-19 on Outcomes in Ischemic Stroke Patients in the United States
Studies have shown worse outcomes in patients with comorbid ischemic stroke (IS) and coronavirus disease 2019 (COVID-19), but have had small sample sizes. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 9, 2020 Category: Neurology Authors: Adam de Havenon, John P. Ney, Brian Callaghan, Alen Delic, Samuel Hohmann, Ernie Shippey, Gregory J. Esper, Eric Stulberg, David Tirschwell, Jennifer Frontera, Shadi Yaghi, Mohammad Anadani, Jennifer J. Majersik Source Type: research

Transcranial Doppler Ultrasound Evidence of Active Cerebral Embolization in COVID-19
: To report six consecutive patients with confirmed coronavirus disease-2019 (COVID-19) who underwent Transcranial Doppler (TCD) ultrasonography evaluation for cerebral microemboli in the setting of suspected or confirmed acute ischemic stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 9, 2020 Category: Neurology Authors: Ayush Batra, Jeffrey R. Clark, Katie LaHaye, Nathan A. Shlobin, Steven C. Hoffman, Zachary S. Orban, Katharine Colton, Jane E. Dematte, Farzaneh A. Sorond, Igor J. Koralnik, Eric M. Liotta Source Type: research

Cost-Effectiveness of Using LDL-Direct Versus Lipid-Panel as Part of the Inpatient Stroke Workup
As part of the investigation for the etiology of ischemic stroke or transient ischemic attack, assessing for modifiable risk factors has become standard practice. One such risk factor is dyslipidemia. The current practice to assess for dyslipidemia is to obtain the low-density-lipoprotein cholesterol (LDL-C) through serology, either by ordering a lipid panel or by ordering a direct LDL in order to obtain a more precise measurement. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 8, 2020 Category: Neurology Authors: Richard Lane, Kunal Agrawal, Royya Modir Source Type: research

Number of Patients with Ischemic Stroke did not Decline in a Regional Stroke Unit After the Implementation of Mechanical Thrombectomy
Objectives: Since the implementation of mechanical thrombectomy (MT) in 2015 for patients with ischemic stroke and large-vessel occlusion, the question arose as to whether patients should be primarily admitted to the nearest regional stroke unit (SU) for prompt intravenous thrombolysis (IVT) or to a more distant supraregional SU performing MT, to avoid secondary-transfer delays in MT. Although an evidence-based answer is still lacking, a discrepant discussion with potential consequences for the regional flow of stroke patients arose. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 8, 2020 Category: Neurology Authors: Stephan Scherzer, Andrea Robledo, Karin Stahl, Sami Nasri, Peter Kraft Source Type: research

Serum Interleukin-33 is a Novel Predictive Biomarker of Hemorrhage Transformation and Outcome in Acute Ischemic Stroke
Hemorrhage Transformation (HT) in acute ischemic stroke (AIS) depends on multiple factors. Some studies have shown that serum interleukin-33 (IL-33) is of central significance as a neuroprotective factor. However, the relationship between serum IL-33 and HT in AIS has not been evaluated. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 8, 2020 Category: Neurology Authors: Zhenlei Chen, Qingzhe Hu, Yingchao Huo, Rongrong Zhang, Qing Fu, Xinyue Qin Source Type: research

Hypertrophic Pachymeningitis Related Brain Infarction in Synovitis-Acne-Pustulosis-Hyperostosis Osteomyelitis Syndrome
A 50-year-old woman with a history of synovitis-acne-pustulosis-hyperostosis osteomyelitis (SAPHO) syndrome was admitted for left unilateral neglect, dysarthria, and left hemiparesis. Brain MRI showed multiple infarctions in the territory of the right middle cerebral artery and gadolinium enhancement of the thickened frontotemporal dura mater on the right side. MR angiography showed significant narrowing of the cavernous segment of the right internal carotid artery. The right internal carotid artery stenosis was thought to originate from hypertrophic pachymeningitis associated with SAPHO syndrome. (Source: Journal of Strok...
Source: Journal of Stroke and Cerebrovascular Diseases - December 8, 2020 Category: Neurology Authors: Yukako Yazawa, Ryo Itabashi Tags: Case Report Source Type: research

Protocatechuic Acid Prevents Early Hour Ischemic Reperfusion Brain Damage by Restoring Imbalance of Neuronal Cell Death and Survival Proteins
Objective: To investigate the neuroprotective effect of protocatechuic acid (PCA) on cell death/survival protein imbalance in a rat model of middle cerebral artery occlusion and reperfusion. Methods: Focal ischemia was induced by middle cerebral artery occlusion in adult male Wistar rats and confirmed by measuring infarction of brain by 2,3,5-Triphenyltetrazolium chloride (TTC) staining. Rats were treated with vehicle or PCA at 10, 30 or 50 mg/kg dose intraperitoneally and subjected to neurological deficits or beam walk assessment at 24 h of reperfusion. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 4, 2020 Category: Neurology Authors: Swapnil Kale, Lopmudra P. Sarode, Amol Kharat, Saurabh Ambulkar, Anand Prakash, Amul J. Sakharkar, Rajesh R. Ugale Source Type: research

Reliability of the Modified Rankin Scale Assessment Using a Simplified Questionnaire in Japanese
We developed a Japanese version of the simplified modified Rankin Scale questionnaire, of which the agreement between patients or their family members and neurologists was verified in a previous single-center study. In the present study, the reliability of the questionnaire was evaluated in another hospital. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 4, 2020 Category: Neurology Authors: Kenichiro Yi, Yuichiro Inatomi, Makoto Nakajima, Toshiro Yonehara, Mitsuharu Ueda Source Type: research

Cerebrovascular disease integration of chronic kidney disease and hypertension
Hanna et  al. rightfully detail the complexity of neural-renal interactions on the genesis and progression of cerebrovascular disease.1 Part of the dilemma with having the scientific and medical communities more fully grasp this interplay is the praeexistens confusion in approaching the definition of cerebr ovascular disease.2 Further to the latter is the general lost art of cerebrovascular disease classification that was duly intended to purposely bridge the gap between the basic and clinical sciences. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 4, 2020 Category: Neurology Authors: Nevio Cimolai Tags: Letter to the Editor Source Type: research

Association Between Carbon Monoxide Intoxication and Incidence of Ischemic Stroke: A Retrospective Nested Case-Control Study in South Korea
Severe neurological sequelae occur in patients with carbon monoxide (CO) intoxication; however, whether the latter increases the long-term risk of developing ischemic stroke is unclear. We investigated the association between CO intoxication and ischemic stroke using data from the Korean National Health Information Database. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 3, 2020 Category: Neurology Authors: Kyeongmin Kwak, Min Kim, Won-Jun Choi, Young-Su Ju, Jong-Tae Park Source Type: research

Red and White Thrombus Characteristics in Patients Undergoing Carotid Endarterectomy
Ischemic heart disease and stroke, which are associated with atherosclerosis in the coronary and carotid arteries, accounted for one-third of deaths worldwide.1 The stroke type can be ischemic or hemorrhagic. Hemorrhagic stroke is divided into intracerebral and subarachnoid hemorrhage types. Ischemic stroke occurs because of small vessel occlusion, large artery atherosclerosis, cardiogenic embolism, and other causes.2 Ischemic stroke and transient ischemic attack (TIA) usually arise from unstable carotid lesions, which cause thrombus formation or carotid artery occlusion. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 2, 2020 Category: Neurology Authors: Hatice Tosun, Suat Kam ışlı, Mehmet Tecellioğlu, Saadet Alan, Fahriye Seçil Tecellioğlu, Mustafa Namık Öztanır, Yüksel Kablan Source Type: research

Neighborhood Socioeconomic Status and Mechanical Thrombectomy Outcomes
Our study aimed to assess the impacts of neighborhood socioeconomic status on mechanical thrombectomy (MT) outcomes for acute ischemic stroke (AIS). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 2, 2020 Category: Neurology Authors: Sanjana Salwi, Katherine A. Kelly, Pious D. Patel, Matthew R. Fusco, Eva A. Mistry, Akshitkumar M. Mistry, Rohan V. Chitale Source Type: research

Cilostazol Addition to Aspirin could not Reduce the Neurological Deterioration in TOAST Subtypes: ADS Post-Hoc Analysis
Our previous trial acute dual study (ADS) reported that dual antiplatelet therapy (DAPT) using cilostazol and aspirin did not reduce the rate of short-term neurological worsening in non-cardioembolic stroke patients. Present post-hoc analysis investigated whether the impact of combined cilostazol and aspirin differed among stroke subtypes and factors associated with neurological deterioration and/or stroke recurrence. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 2, 2020 Category: Neurology Authors: Junya Aoki, Yasuyuki Iguchi, Takao Urabe, Hiroshi Yamagami, Kenichi Todo, Shigeru Fujimoto, Koji Idomari, Nobuyuki Kaneko, Takeshi Iwanaga, Tadashi Terasaki, Ryota Tanaka, Nobuaki Yamamoto, Akira Tsujino, Koichi Nomura, Koji Abe, Masaaki Uno, Yasushi Okad Source Type: research

Intravenous Thrombolysis before Thrombectomy may Increase the Incidence of Intracranial Hemorrhage inTreating Carotid T Occlusion
This study aimed to compare the safety and efficacy of direct thrombectomy (DT) and bridging thrombectomy (BT) in treating patients with acute ischaemic stroke due to carotid T occlusion. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 1, 2020 Category: Neurology Authors: Mingyang Du, Shun Li, Xianjun Huang, Shuai Zhang, Yongjie Bai, Bin Yan, Hongquan Guo, Gelin Xu, Xinfeng Liu Source Type: research

miR-221 Exerts Neuroprotective Effects in Ischemic Stroke by Inhibiting the Proinflammatory Response
Ischemic stroke is a common neurological disorder worldwide and is associated with a high probability of permanent disability.2 Unfortunately, our response to stroke is still extremely limited. Thus, since the exploration of novel and effective strategies is still the focus and is a well-studied topic in stroke treatment, recent research has focused on elucidating the molecular mechanisms of stroke, especially as those mechanisms pertain to novel treatment targets. Emerging experimental data have confirmed that microRNAs (miRNAs) are essential regulatory factors in ischemic stroke and other neurological diseases. (Source: ...
Source: Journal of Stroke and Cerebrovascular Diseases - December 1, 2020 Category: Neurology Authors: Yuan Shan, Jun Hu, Hua Lv, Xiaoli Cui, Wei Di Source Type: research

Mean Platelet Volume may not be a Marker for Prognosis in Patients with Aneurysmal Subarachnoid Hemorrhage
Dear Editor, (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 1, 2020 Category: Neurology Authors: Cengiz Beyan, Esin Beyan Tags: Letter to the Editor Source Type: research

Disabling Wake Up Stroke without Lesions on Initial Diffusion Weighted Imaging - Case Report and Clinical Implications
An 86-year-old lady presented after waking up with left sided paresis and neglect. Right hemispheral stroke was suspected, but initial MRI with Diffusion Weighted Imaging (DWI) was negative and there was no large vessel occlusion. We accordingly withheld intravenous thrombolysis. She did not improve clinically and follow-up MRI after three days showed a marked lesion compatible with acute ischemic stroke in the right middle cerebral artery territory. This case shows that even with a disabling stroke in the anterior circulation initial DWI may be negative. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 1, 2020 Category: Neurology Authors: Elke Andrea van de Ven, Floor Anne Sophie de Kort, Jan Albert Vos, Joost Peter Kerklaan Tags: Case Report Source Type: research

Determinants of Long-Term Health-Related Quality of Life in Young Ischemic Stroke Patients
The burden of stroke is multidimensional. The most commonly assessed stroke outcomes tend to be mortality and disability, which are physician reported measures. On the other hand, the health-related quality of life (HRQOL) measure evaluates stroke outcomes from the patients ’ perspective. It provides valuable information in that it rates physical, emotional, social, and other domains, and has repeatedly been associated with mortality.1,2 (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 1, 2020 Category: Neurology Authors: Siim Schneider, Nele Taba, Minni Saapar, Riina Vibo, Janika K õrv Source Type: research

Management of Intracranial Hemorrhage in Patients with a Left Ventricular Assist Device: A Systematic Review and Meta-Analysis
Left Ventricular Assist Device (LVAD) therapy serves as a surgically implanted form of mechanical circulation in patients with advanced heart failure. Initially designed to provide a bridge to transplant, LVADs now offer an alternative that is increasingly utilized as final destination therapy as the need for donor hearts increases worldwide.1,2 However, this requires lifelong anticoagulation (AC) to prevent pump thrombosis, resulting in hemorrhagic risks.3 (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 1, 2020 Category: Neurology Authors: Austin H. Carroll, Michael P. Ramirez, Ehsan Dowlati, Kyle B. Mueller, Ali Borazjani, Jason J. Chang, Daniel R. Felbaum Tags: Review Article Source Type: research

Infarct Recurrence in Intracranial Atherosclerosis: Results from the MyRIAD Study
Intracranial atherosclerotic disease (ICAD) is a common cause of ischemic stroke with a high risk of clinical stroke recurrence. Multiple mechanisms may underlie cerebral ischemia in this condition. The study's objective is to discern the mechanisms of recurrent ischemia in ICAD through imaging biomarkers of impaired antegrade flow, poor distal perfusion, abnormal vasoreactivity, and artery-to-artery embolism. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 1, 2020 Category: Neurology Authors: Jose G. Romano, Shyam Prabhakaran, Azhar Nizam, Edward Feldmann, Rajbeer Sangha, George Cotsonis, Iszet Campo-Bustillo, Sebastian Koch, Tatjana Rundek, Marc I. Chimowitz, David S. Liebeskind, MyRIAD Investigators Source Type: research

National Trends in Utilization and Outcome of Endovascular Thrombectomy for Acute Ischemic Stroke in Elderly
Octogenarians were excluded and/or underrepresented in the major endovascular thrombectomy (EVT) randomized controlled trials, but continue to make up a growing proportion of stroke patients. To evaluate real-world trends in utilization and outcome of EVT in patients ≥80 years in a large nationally representative database. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 1, 2020 Category: Neurology Authors: Amol Mehta, Johanna T Fifi, Hazem Shoirah, I.Paul Singh, Tomoyoshi Shigematsu, Christopher P Kellner, Reade De Leacy, J Mocco, Shahram Majidi Source Type: research

Mechanism of Stroke According to the Severity and Location of Atherosclerotic Middle Cerebral Artery Disease
Strategy for secondary prevention of ischemic stroke depends on the mechanism of stroke. The aim of this study was to compare the stroke mechanism according to the location and severity of middle cerebral artery (MCA) disease. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 30, 2020 Category: Neurology Authors: Sang Hee Ha, Jun Young Chang, Sang Hun Lee, Kyung Mi Lee, Sung Hyuk Heo, Dae-il Chang, Bum Joon Kim Source Type: research

Mechanisms of Cerebral Microvascular Disease in Chronic Kidney Disease
Numerous studies report linkage between chronic kidney disease (CKD) and cerebrovascular disease. This association has been particularly strong for cerebral small vessel disease. Significant findings have emerged from studies ranging from case reports, small case series, and larger cohort investigations. The latter show a relationship between declining renal function, microvascular disease, and cognitive impairment. One troubling aspect has been the relative paucity of mechanistic investigations addressing the CKD-cerebrovascular disease linkage. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 30, 2020 Category: Neurology Authors: Mark Fisher Source Type: research

Re: Patterns of Mechanical Thrombectomy for Stroke Before and After the 2015 Pivotal Trials and US National Guideline Update
In this study, the authors investigated two temporally distinct groups in the National Inpatient Sample (NIS): 1) AIS patients undergoing thrombectomy between January 2012 through December 2014; 2) AIS patients undergoing thrombectomy between October 2015 through December 2016. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 28, 2020 Category: Neurology Authors: Steven Mulackal Thomas Tags: Letter to the Editor Source Type: research

Factors Associated with Stroke Coding Quality: A Comparison of Registry and Administrative Data
The International Statistical Classification of Diseases and Related Health Problems, 10th Revision, Australian Modification (ICD-10-AM) codes are commonly used to identify patients with diseases or clinical conditions for epidemiological research. We aimed to determine the diagnostic agreement and factors associated with a clinician-assigned stroke diagnosis in a national registry and the ICD-10-AM codes recorded in government-held administrative data. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 27, 2020 Category: Neurology Authors: Olivia F. Ryan, Merilyn Riley, Dominique A. Cadilhac, Nadine E. Andrew, Sibilah Breen, Kate Paice, Sam Shehata, Vijaya Sundararajan, Natasha A. Lannin, Joosup Kim, Monique F. Kilkenny Source Type: research

Ultra-Early Venous Thromboembolism (VTE) Prophylaxis in Spontaneous Intracerebral Hemorrhage (sICH)
To determine if ultra-early ( (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 27, 2020 Category: Neurology Authors: Mohammed F. Kananeh, Mario J. Fonseca-Paricio, John W. Liang, Lindsay T. Sullivan, Kumud Sharma, Syed Omar Shah, Matthew D. Vibbert Source Type: research

Clinical Features, Risk Factors, and Early Prognosis for Wallerian Degeneration in the Descending Pyramidal Tract after Acute Cerebral Infarction
Wallerian degeneration(WD) occurs in the descending pyramidal tract(DPT) after cerebral infarction commonly, but studies of its degree evaluation, influencing factors and effects on nervous function are still limited. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 27, 2020 Category: Neurology Authors: Xiaolu Zheng, Yang Zhang, Yi Man, Zhangyong Hu, Nan Zhang, Sipei Pan Source Type: research

Stroke Research Disparity in Southeast Asia: Socioeconomic Factors, Healthcare Delivery, and Stroke Disease Burden
In recent decades, non-communicable diseases have outpaced communicable diseases as the leading causes of infirmity and loss of life and livelihood. One in four people over age 25 will experience a stroke in their lifetime.1 In low- to low-middle income countries (LMICs), stroke occurs at a younger age compared to high-income countries, contributing to a disproportionate amount of disability-adjusted life years (DALYs) lost and economic liabilities.2,3 (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 27, 2020 Category: Neurology Authors: Almira Doreen Abigail O. Apor, Gerald T. Pagaling, Adrian I. Espiritu, Roland Dominic G. Jamora Source Type: research

Comprehensive and Structured 3-month Stroke Follow-up Using the Post-stroke Checklist (The Struct-FU study): A Feasibility and Explorative Study
There is recent evidence supporting that a comprehensive post-stroke treatment program improves outcome. However, the prevalence of stroke-related health problems and the extent of needed interventions have not been well-delineated. The Struct-FU study aims to assess the feasibility of a comprehensive stroke follow-up model and to map stroke-related problems and subsequent multidisciplinary interventions using a modified Post-stroke Checklist (PSC). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 27, 2020 Category: Neurology Authors: Teresa Ullberg, Kristina M ånsson, Ida Berhin, Hélène Pessah-Rasmussen Source Type: research

Clinical Features for Identifying the Possibility of Toileting Independence after Convalescent Inpatient Rehabilitation in Severe Stroke Patients: A Decision Tree Analysis Based on a Nationwide Japan Rehabilitation Database
This study aimed to identify the factors affecting toileting independence in severe stroke patients using ML. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 27, 2020 Category: Neurology Authors: Takeshi Imura, Yu Inoue, Ryo Tanaka, Junji Matsuba, Yasutaka Umayahara Source Type: research

Development and Internal Validation of a Nomogram to Predict Post-Stroke Fatigue After Discharge
Post-stroke fatigue (PSF) is a common condition of stroke, even in those with good neurological recovery.1,2 It can be experienced following a stroke at any point during the recovery process and is likely to persist in the long term. A systematic review indicated that PSF is present in more than one-third of all stroke survivors at any time during the follow-up within 2 years.3 PSF not only interferes with participation in rehabilitation therapy and daily activities, but also adversely affects patient outcomes and return to work capability. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 27, 2020 Category: Neurology Authors: Ya Su, Michiko Yuki, Kengo Hirayama, Mika Otsuki Source Type: research