Safety and Efficacy Profile of Off-Label Use of the Pipeline Embolization Device: A Systematic Review and Meta-Analysis
It has been more than ten years since the initial Food and Drug Administration (FDA) approved the first flow diverters (FDs) for treating brain aneurysms.1 The approval of these devices was made possible due to the safety and efficacy demonstrated in both the single-arm Pipeline Embolization Device(PED) for the intracranial treatment of aneurysm trial2 and the Pipeline for Uncoilable or Failed aneurysms (PUFs) trial.3,4 The FDA initially approved the indications for the flow diverters based on the inclusion criteria of the PED for the intracranial treatment of aneurysms trial (PITA) and extrapolated from its results. (Sour...
Source: Journal of Stroke and Cerebrovascular Diseases - January 17, 2024 Category: Neurology Authors: Yigit Can Senol, Atakan Orscelik, Cem Bilgin, Hassan Kobbeisi, Sherief Ghozy, Santhosh Arul, David F Kallmes, Ramanathan Kadirvel Source Type: research

Diagnostic feasibility of middle cerebral artery stenosis or occlusion evaluated by TCCS and CEUS: Repeatability, reproducibility, and diagnostic agreement with DSA
This study aimed to evaluate the feasibility of transcranial color-coded sonography (TCCS) and contrast-enhanced ultrasound (CEUS) in assessing middle cerebral artery (MCA) stem stenosis or occlusion compared to digital subtraction angiography (DSA). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 16, 2024 Category: Neurology Authors: Lei Zhang, Tianning Pu, Xiaotong Xu, Raynald, Shuai Zheng, Jingjing Fu, Qiang Yong, Wei Zhang, Wen He Source Type: research

Cost-benefit analysis of intraoperative neuromonitoring for cardiac surgery
Intraoperative neuromonitoring (IONM) can detect large vessel occlusion (LVO) in real-time during surgery. The aim of this study was to conduct a cost-benefit analysis of utilizing IONM among patients undergoing cardiac surgery. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 16, 2024 Category: Neurology Authors: Bhav Jain, Faraan O. Rahim, Parthasarathy D. Thirumala, Michael L. McGarvey, Jeffrey Balzer, Raul G. Nogueira, David N. van der Goes, Adam de Havenon, Ibrahim Sultan, John Ney Source Type: research

An L-shaped association between composite dietary antioxidant index and stroke: Evidence from NHANES 2011-2020
This study aimed to investigate the correlation between the Composite Dietary Antioxidant Index (CDAI) and stroke in adults. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 16, 2024 Category: Neurology Authors: Jiesheng Mao, Yunhan Zhao, Haoxiang Hu, Mi Zhou, Xiaokai Yang Source Type: research

Understanding the Relationship Between Social Risk Factors and Functional Limitation among Stroke Survivors in the US
Stroke is the fifth leading cause of death and disability in the United States. Social risk factors contribute to recovery from stroke, however the relationship between social risk factors and functional limitation among stroke survivors remains unknown. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 16, 2024 Category: Neurology Authors: Jennifer Terrell, Jennifer A. Campbell, Abigail Thorgerson, Sanjay Bhandari, Leonard E. Egede Source Type: research

Non-aneurysmal subarachnoid hemorrhage in aplastic or twig-like middle cerebral artery: a case report and literature review
Aplastic or twig-like middle cerebral artery (Ap/T-MCA) is a rare vascular anomaly that can cause hemorrhagic and ischemic stroke. Ap/T-MCA can induce aneurysms due to the fragility of the vessel wall, consequently leading to subarachnoid hemorrhage. Herein, we report a case of Ap/T-MCA with subarachnoid hemorrhage without an aneurysm. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 16, 2024 Category: Neurology Authors: Masato Kawakami, Satoshi Murai, Noboru Kusaka, Fukiko Baba, Yohei Inoue, Hayato Miyake, Yukei Shinji, Hisakazu Itami, Shinji Otsuka, Tsukasa Nishiura, Kotaro Ogihara Tags: Case Report Source Type: research

Mechanism of scutellarin inhibition of astrocyte activation to type A1 after ischemic stroke
The aim of this study was to investigate the effects of scutellarin on the activation of astrocytes into the A1 type following cerebral ischemia and to explore the underlying mechanism. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 13, 2024 Category: Neurology Authors: Yongwei Zou, Jingchun Pei, Cheng Wan, Shuangshuang Liu, Bin Hu, Zhigao Li, Zhiwei Tang Source Type: research

Neuregulin 1 as a Potential Biomarker for Disease Progression in Moyamoya Disease: A Case-Control Study in Chinese Population
Moyamoya disease (MMD) is a rare and progressive stenosis of cerebral arteries characterized by abnormally proliferative vasculopathy. Current studies have demonstrated that Neuregulin 1 (NRG1) plays a key role in angiogenesis-related disorders. Thus, the aim of our study is to investigate the serum NRG1 levels and their clinical correlations in MMD patients. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 12, 2024 Category: Neurology Authors: Jie Chen, Hanyue Zheng, Xiaoxin Wu, Xingyang Niu, Yuanyuan Dai, Zhenhua Zhou, Fei Ye Source Type: research

Optimizing Workflow of Urgent Stroke Endovascular Intervention: A Focused Lean Six Sigma Project
: Urgent endovascular intervention is currently accepted as the primary and critical therapeutic approach to patients whose acute ischemic stroke results from a large arterial occlusion (LAO). In this context, one of the quality metrics most widely applied to the assessment of emergency systems performance is the “door-to-puncture” (D-P) time. We undertook a project to identify the subinterval of the D-P metric causing the most impact on workflow delays and created a narrowly focused project on improving such subinterval. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 12, 2024 Category: Neurology Authors: Camilo R. Gomez, Bradford Cardonell, Kimberley Pfeiffer, Donna Pond, Daphne Ingebritson, Brandi R. French, Farhan Siddiq, Adnan I. Qureshi Source Type: research

Sex-Specific Racial and Ethnic Variations in Short-Term Outcomes Among Patients with First or Recurrent Ischemic Stroke: Paul Coverdell National Acute Stroke Program, 2016-2020
Background and Purpose: To understand the association of sex-specific race and ethnicity on the short-term outcomes of initial and recurrent ischemic stroke events. Methods: Using the Paul Coverdell National Acute Stroke Program from 2016-2020, we examined 426,062 ischemic stroke admissions from 629 hospitals limited to non-Hispanic White (NHW), non-Hispanic Black (NHB), and Hispanic patients. We performed multivariate logistic regression analyses to assess the combined effects of sex-specific race and ethnicity on short-term outcomes for acute ischemic stroke patients presenting with initial or recurrent stroke events. (S...
Source: Journal of Stroke and Cerebrovascular Diseases - January 12, 2024 Category: Neurology Authors: Ganesh Asaithambi, Mary G. George, Xin Tong, Kamakshi Lakshminarayan Source Type: research

High frequency neuronavigated repetitive transcranial magnetic stimulation in post-stroke shoulder pain: A double-blinded, randomized controlled study
Stroke is a leading cause of mortality and disability among adults (1). Hemiplegic shoulder pain (HSP) is one of the most common complications after stroke (2). It is an important problem that prolongs hospital stay, limits independence in activities of daily living, prevents rehabilitation and is associated with low quality of life and depression in stroke patients (3). The exact aetiology of shoulder pain after stroke is often difficult to determine. Many possible underlying causes have been identified, including rotator cuff lesions, biceps tendinopathy, soft tissue disorders such as myofascial pain, glenohumeral sublux...
Source: Journal of Stroke and Cerebrovascular Diseases - January 12, 2024 Category: Neurology Authors: Ya ğmur AYDIN, Ayhan AŞKIN, Nazrin AGHAZADA, İlker ŞENGÜL Source Type: research

In Reply to the Letter to the Editor Regarding: Sarcopenia is a predictor of patient death in acute ischemic stroke
Dear professor von Haehling, thank you very much for your interest in our article1. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 12, 2024 Category: Neurology Authors: Alexey Surov, Jan Borggrefe Tags: Letter to the Editor Source Type: research

The Impact of Pre-Stroke Aspirin Exposure on Radiographic Appearance and Disability Outcomes: A Post-Hoc Analysis of the SPS3 Trial
The effect of pre-stroke use of aspirin on small subcortical infarct dimensions or outcomes is not well described. We aimed to bridge this knowledge gap amongst a well-described and heterogeneous patient population. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 12, 2024 Category: Neurology Authors: Eric D. Goldstein, Sabrina Q.R. Liew, Liqi Shu, Shadi Yaghi Source Type: research

Predictive value of serum MDA and 4-HNE levels on the occurrence of early neurological deterioration after intravenous thrombolysis with rt-PA IVT in patients with acute ischemic stroke
This study investigated the predictive value of serum MDA and 4-HNE levels on early neurological deterioration (END) after recombinant tissue plasminogen activator (rt-PA) intravenous thrombolysis (IVT) in acute ischemic stroke (AIS) patients. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 12, 2024 Category: Neurology Authors: Lihong Zhang, Di Li, Ce Zhang, Jianhui Zhang, Jia Xu, Lan Bai, Jianping Xu, Cui Wang Source Type: research

Utility of the triglyceride-glucose index for predicting restenosis following revascularization surgery for extracranial carotid artery stenosis: A retrospective cohort study
Revascularization of extracranial carotid artery stenosis (ECAS) is an effective strategy to prevent ischemic stroke1. The most important mechanism leading to ECAS and ensuing stroke is rupture of atherosclerotic plaques, which are frequently located at the carotid artery bifurcation in the neck. After rupture, plaque lipid components are exposed to the blood vessel lumen, resulting in platelet aggregation and thrombus formation. Eventually, these thrombi detach from the vessel wall and block downstream arteries, leading to ischemic stroke2. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 11, 2024 Category: Neurology Authors: Xiao-Peng Qu, Ying-Le Wu, Liang-Liang Shen, Chao Wang, Li Gao, Jia-Qi Ma, Yan Qu, Bei Liu Source Type: research