Early Identification of Protein S K196E Mutation in a Patient With Cerebral Venous Thrombosis: A Case Report
We report a case of CVT that was diagnosed as having PS K196E mutation at the initial thrombotic event. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 20, 2018 Category: Neurology Authors: Kyohei Fujita, Kazutaka Sonoda, Toshiyuki Miyata, Masafumi Ihara, Kazunori Toyoda, Masatoshi Koga Source Type: research

Impact of Treatment Time on the Long-Term Outcome of Stroke Patients Treated With Mechanical Thrombectomy
To assess the long-term functional outcome of stroke in patients treated with mechanical thrombectomy (MT) performed during work hours (on-hours) versus after-hours, weekends, and official holidays (off-hours). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 19, 2018 Category: Neurology Authors: Eyad Almallouhi, Sami Al Kasab, Jillian B. Harvey, Christopher Reardon, Ali Alawieh, Tarun Girotra, Patricia Aysse, Raymond D. Turner, Christine A. Holmstedt Source Type: research

Response to “The NAG Scale: Noble Predictive Scale for Hematoma Expansion in Intracerebral Hemorrhage”
We read with great interest the article entitled “The NAG scale: Noble Predictive Scale for Hematoma Expansion in Intracerebral Hemorrhage” by Sakuta et al1 Hematoma expansion is an important predictor of mortality and is more significant in patients on oral anticoagulants.1,2 Identification of reliable and early predictors of hematoma growth is important in the treatment of Intracerebral Hemorrhage.2 (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 17, 2018 Category: Neurology Authors: Ajay Hegde Tags: Letter to the Editor Source Type: research

Predictors of Recurrent Hospitalizations and the Importance of These Hospitalizations for Subsequent Mortality After Incident Transient Ischemic Attack
We examined predictors of recurrent hospitalizations and the importance of these hospitalizations for subsequent mortality after incident transient ischemic attacks (TIA) that have not yet been investigated. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 17, 2018 Category: Neurology Authors: Mohammed Yousufuddin, Nathan Young, Jessica Shultz, Taylor Doyle, Karen M. Fuerstenberg, Kelsey Jensen, Kogulavadanan Arumaithurai, Mohammad H. Murad Source Type: research

Derivation of a Prediction Rule for Unfavorable Outcome after Ischemic Stroke in the Chinese Population
Efficient assessment of patients after ischemic stroke has important reference value for doctors to choose appropriate treatment for patients. Our study aimed to develop a new prognostic model for predicting outcomes 3 months after ischemic stroke among Chinese Population. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 16, 2018 Category: Neurology Authors: Haifeng Mao, Qianyi Wu, Peiyi Lin, Junrong Mo, Huilin Jiang, Shaopeng Lin, Timothy H. Rainer, Xiaohui Chen Source Type: research

Calpeptin Reduces Neurobehavioral Deficits and Neuronal Apoptosis Following Subarachnoid Hemorrhage in Rats
This study was undertaken to determine the effects of inhibition of calpain on neurological deficit and neuronal apoptosis following experimental SAH. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 15, 2018 Category: Neurology Authors: You-dong Zhou, Li Cai Source Type: research

Two Medullary Hemorrhage Cases Complicated by Respiratory Distress in the Early Phase
Medullary hemorrhage is quite rare among brain stem hemorrhage cases, thus the clinical course remains unclear. In the medulla oblongata, respiratory centers are located and previous reports indicate that medullary lesions have possible relationship with acute respiratory distress syndrome. This kind of respiratory failure is commonly caused by neurogenic pulmonary edema (NPE), which is defined as noncardiac noninfectious acute respiratory distress syndrome with changes in intracranial condition including cerebrovascular events. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 15, 2018 Category: Neurology Authors: Ryuichiro Yagi, Yoshinori Nishimoto, Satoshi Yamada, Hanae Nakashima, Kensuke Okada, Fumie Konoeda, Haruhiko Hoshino Tags: Case Studies Source Type: research

Application of High-Resolution CUBE Sequence in Exploring Stroke Mechanisms of Atherosclerotic Stenosis of Middle Cerebral Artery
This study aimed to analyze the vascular wall and atherosclerotic plaques of the middle cerebral artery (MCA) and compare their differences between patients with cerebral infarction and transient ischemic attack (TIA) using 3-dimensional fast-spin-echo T1-weighted sequence (namely CUBE). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 13, 2018 Category: Neurology Authors: Jianye Liang, Jun Guo, Dexiang Liu, Changzheng Shi, Liangping Luo Source Type: research

Overexpression of miR-582-5p Inhibits the Apoptosis of Neuronal Cells after Cerebral Ischemic Stroke Through Regulating PAR-1/Rho/Rho Axis
The purpose of this study was to explore the role of miR-582-5p/proteinase-activated receptors type I (PAR-1)/Rho/Rho in neuronal cell apoptosis after cerebral ischemic stroke (CIS). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 13, 2018 Category: Neurology Authors: Hongsheng Ding, Shan Gao, Lei Wang, Yan Wei, Meiyun Zhang Source Type: research

Isolated Anisocoria as a Presenting Stroke Code Symptom is Unlikely to Result in Alteplase Administration
Acute stroke codes may be activated for anisocoria, but how often these codes lead to a final stroke diagnosis or alteplase treatment is unknown. The purpose of this study was to assess the frequency of anisocoria in stroke codes that ultimately resulted in alteplase administration. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 13, 2018 Category: Neurology Authors: Victoria A. Chang, Dawn M. Meyer, Brett C. Meyer Source Type: research

Book Review of “Uncommon Causes of Stroke,” 3rd Ed. 2018, Edited by Louis Caplan and José Biller, DOI: 10.1017/9781316551684
The third edition of Uncommon Causes of Stroke,1 edited by Louis Caplan and Jos é Biller, is a comprehensive reference manual that belongs on the bookshelf of providers who care for patients with cerebrovascular diseases. Like its popular sister, Stroke Syndromes, the chapters are exhaustively researched and referenced and readily fill the gaps in our routine knowledge. Expand ed from the previous edition, the 77 chapters are organized into sections on infectious, inflammatory, and systemic conditions, hereditary and genetic conditions and malformations, vascular disorders affecting the eyes, ears, and brain, coagul...
Source: Journal of Stroke and Cerebrovascular Diseases - October 13, 2018 Category: Neurology Authors: Cathy Sila Source Type: research

Different Clinical Phenotypes of Embolic Stroke of Undetermined Source: A Subgroup Analysis of 86 Patients
This study researches clinically relevant phenotypes among ESUS patients. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 12, 2018 Category: Neurology Authors: Silvio Piffer, Valeria Bignamini, Umberto Rozzanigo, Piero Poletti, Stefano Merler, Elisabetta Gremes, Domenico Marco Bonifati Source Type: research

Adequate Adherence to Direct Oral Anticoagulant is Associated with Reduced Ischemic Stroke Severity in Patients with Atrial Fibrillation
The impact of adherence to direct oral anticoagulants (DOACs) is unknown. We aimed to assess the effects of preceding anticoagulation treatment on neurologic severity at admission and functional outcomes at discharge in patients with atrial fibrillation (AF) who developed acute ischemic stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 12, 2018 Category: Neurology Authors: Kazuo Yamashiro, Naohide Kurita, Ryota Tanaka, Yuji Ueno, Nobukazu Miyamoto, Kenichiro Hira, Sho Nakajima, Takao Urabe, Nobutaka Hattori Source Type: research

Addition of Suvorexant to Ramelteon Therapy for Improved Sleep Quality with Reduced Delirium Risk in Acute Stroke Patients
Delirium in acute stroke is associated with poor clinical outcome. The purpose of this study was to examine the effect of sleep medications on sleep quality and delirium in acute stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 12, 2018 Category: Neurology Authors: Kei Kawada, Tsuyoshi Ohta, Koudai Tanaka, Mitsuhiko Miyamura, Satoshi Tanaka Source Type: research

Bioccipital Lobe Hypoperfusion and Anton's Syndrome Resolution with Intravenous Thrombolysis
Anton's syndrome is a rare neurological disorder characterized by a combination of visual anosognosia and confabulation of visual experience, most often seen after bilateral ischemic damage to the posterior occipital cortex. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 10, 2018 Category: Neurology Authors: Lukas T. Rotkopf, Wolfgang G. Kunz, Felix G. Meinel, Annika Plate, S önke Langner, Matthias Klein, Kolja M. Thierfelder Source Type: research

Differential MicroRibonucleic Acid Expression in Cardioembolic Stroke
This study examines stroke-specific miRNA expression in large vessel territory cardioembolic stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 10, 2018 Category: Neurology Authors: Janhavi M. Modak, Meaghan Roy-O'Reilly, Liang Zhu, Ilene Staff, Louise D. McCullough Source Type: research

Sinusoidal Transcranial Direct Current Versus Galvanic Vestibular Stimulation for Treatment of Lateropulsion Poststroke
To compare the effects of Transcranial Direct Current Stimulation (tDCS) versus Galvanic Vestibular Stimulation (GVS) on Lateropulsion following stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 9, 2018 Category: Neurology Authors: Suzanne Babyar, Taiza Santos, Tenysson Will-Lemos, Suleimy Mazin, Dylan Edwards, Michael Reding Source Type: research

Plasma miR-126 and miR-143 as Potential Novel Biomarkers for Cerebral Atherosclerosis
Cerebral atherosclerosis is the most important mechanism for ischemic stroke. However, specific plasma biomarkers to assess atherosclerosis susceptibility are still lacking. Circulating miRNAs have been shown to be promising biomarkers for various pathologic conditions. We investigated whether plasma miR-126 and miR-143 could be used as biomarkers for identifying and evaluating cerebral atherosclerosis. Results showed that miR-143 and miR-126 might participate in the process of atherosclerosis and were minimally affected by cerebral infarction. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 9, 2018 Category: Neurology Authors: Jing Gao, Shuna Yang, Kun Wang, Qianwei Zhong, Aijun Ma, Xudong Pan Source Type: research

The Efficacy of Lower Extremity Mirror Therapy for Improving Balance, Gait, and Motor Function Poststroke: A Systematic Review and Meta-Analysis
Mirror therapy is less commonly used to target the lower extremity after stroke to improve outcomes but is simple to perform. This review and meta-analysis aimed to evaluate the efficacy of lower extremity mirror therapy in improving balance, gait, and motor function for individuals with stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 9, 2018 Category: Neurology Authors: Dennis R. Louie, Shannon B. Lim, Janice J. Eng Source Type: research

MMP-9 Upregulation is Attenuated by the Monoclonal TLR2 Antagonist T2.5 After Oxygen –Glucose Deprivation and Reoxygenation in Rat Brain Microvascular Endothelial Cells
Blood-brain barrier (BBB) disruption plays a key role in the pathophysiology of acute ischemic stroke. Matrix metalloproteinases-2/9 (MMP-2/9) have been shown to participate in the disruption of the BBB and hemorrhagic transformation after cerebral ischemia. Toll-like receptor 2 (TLR2) may also be correlated with endothelial cell injury during ischemia-reperfusion events. However, the correlation between MMP-2/9 and TLR2 on endothelial cells after ischemia has not yet been evaluated. The aim of the study was to evaluate the impact of TLR2 and MMP-2/9 on tight junction proteins (TJs) after oxygen –glucose deprivation ...
Source: Journal of Stroke and Cerebrovascular Diseases - October 8, 2018 Category: Neurology Authors: Hongyan Zhu, Rongrong Dai, Hao Fu, Qiang Meng Source Type: research

Handling of Missing Outcome Data in Acute Stroke Trials: Advantages of Multiple Imputation Using Baseline and Postbaseline Variables
In acute stroke randomized trials, missingness of final functional outcome data reduces study power and potentially biases findings of treatment effect. Best methods for handling missing outcome data have not been well delineated for diseases with monophasic onset and subsequent improvement, like acute stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 6, 2018 Category: Neurology Authors: Dashiell F. Young-Saver, Jeffrey Gornbein, Sidney Starkman, Jeffrey L. Saver Source Type: research

Secular Trends in the Background of Intracerebral Hemorrhage from 2010 to 2015
Direct oral anticoagulants (DOACs) were recently introduced for the clinical use in stroke prevention, and they are reported to show a lower risk of intracerebral hemorrhage (ICH) compared to warfarin. We were interested to know whether there is any change in clinical backgrounds of ICH patients to date. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 6, 2018 Category: Neurology Authors: Taizen Nakase, Junta Moroi, Tatsuya Ishikawa Source Type: research

Epidemiology and Outcomes of Ischemic Stroke and Transient Ischemic Attack in the Adult and Geriatric Population
Background: Rate of ischemic strokes and transient ischemic attacks (TIAs) increases with age. There is lack of evidence on how age affects treatment strategies and outcomes. Our aim is to compare epidemiology of ischemic strokes and TIAs in adult and geriatric populations including risk factors, treatment delivered, and outcomes. Design: We designed a retrospective cross-sectional review of patients admitted to neurology with diagnosis of stroke or TIA from 2010 to 2015. Obtained variables were: age, sex, risk factors, acute therapy, National Institutes of Health Stroke Scale on admission and discharge, and disposition. (...
Source: Journal of Stroke and Cerebrovascular Diseases - October 6, 2018 Category: Neurology Authors: Allison Navis, Rocio Garcia-Santibanez, Maryna Skliut Source Type: research

Left Atrial or Left Atrial Appendage Thrombus Resolution After Adjustment of Oral Anticoagulant Treatment
Background: There are few reports about non-vitamin K antagonist oral anticoagulant (NOAC) treatment for resolution of left atrium (LA) or left atrial appendage (LAA) thrombus. LAA thrombus is an important cause of cardiogenic cerebral thromboembolism, and the detection rate increases due to more and more patients receiving catheter ablation. However, the results from NOAC use for LA or LAA thrombus are still unknown in real-world practice. The aim of this study was to discover the resolution of LA or LAA thrombus after anticoagulant treatment in real-world practice. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 6, 2018 Category: Neurology Authors: Wei-Chieh Lee, Chih-Yuan Fang, Yung-Lung Chen, Hsiu-Yu Fang, Huang-Chung Chen, Wen-Hao Liu, Morgan Fu, Mien-Cheng Chen Source Type: research

Masthead
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 5, 2018 Category: Neurology Source Type: research

Editorial Board
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 5, 2018 Category: Neurology Source Type: research

Table of Contents
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 5, 2018 Category: Neurology Source Type: research

History of Carotid Occlusions: The Contribution of Egas Moniz
To describe the first cases of carotid occlusions identified by the Portuguese neurologist Egas Moniz while performing the cerebral angiography he invented. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 5, 2018 Category: Neurology Authors: Victor Oliveira Source Type: research

Stroke Epidemiology in Argentina. Design of a Population-Based Study in General Villegas (EstEPA)
Epidemiological data on stroke is scarce in Latin America. Estudio Epidemiol ógico Poblacional sobre Accidente Cerebrovascular (EstEPA) is a population-based program planned to assess prevalence, incidence, mortality, and burden of disease for stroke in the Department of General Villegas, province of Buenos Aires, Argentina. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 4, 2018 Category: Neurology Authors: Virginia A. Pujol Lereis, Mario O. Melcon, Maximiliano A. Hawkes, Maia M. Gomez Schneider, Daiana E. Dossi, Mat ías J. Alet, Guillermo P. Povedano, Claudio D. Gonzalez, Sebastián F. Ameriso Source Type: research

Does the Magnitude of the Electrocardiogram QT Interval Dispersion Predict Stroke Outcome?
QT dispersion, maximal interlead difference in QT interval on 12-lead electrocardiogram (ECG), measures cardiac repolarization abnormalities. Data are conflicting whether QT dispersion predicts adverse outcome in acute ischemic stroke (AIS) patients. Our objective is to determine if QT dispersion predicts: (1) short-term clinical outcome in AIS, and (2) stroke location (insular versus noninsular cortex). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 3, 2018 Category: Neurology Authors: Yitzchok S. Lederman, Clotilde Balucani, Leah R. Steinberg, Charles Philip, Jason M. Lazar, Jeremy Weedon, Gautam Mirchandani, Sarah Z. Weingast, Giovanna Viticchi, Lorenzo Falsetti, Mauro Silvestrini, James J. Gugger, David Aharonoff, Pirouz Piran, Zacha Source Type: research

Clinical Outcomes of Valvular versus Nonvalvular Atrial Fibrillation in Acute Anterior Circulation Occlusive Stroke Undergoing Endovascular Treatment
Thrombectomy is the first choice for cardioembolism due to atrial fibrillation (AF), however, whether valvular AF and nonvalvular AF had different safety and functional outcomes has not been reported yet. We aimed to investigate the differences between patients with valvular AF and patients with nonvalvular AF on safety and functional outcomes in acute large artery occlusion undergoing thrombectomy. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 3, 2018 Category: Neurology Authors: Wenchen Li, Shang Wang, Shijun Li, Xin Chen, Yunyun Xiong Source Type: research

Clinical Outcome of Ischemic Stroke in Old Patients Versus Oldest-Old
Background: It is unclear whether very old patients benefit from stroke unit. The aim of our work was to compare the clinical outcome of patients with ischemic stroke aged either 70 or 80 (G 1) versus oldest-old greater than or equal to 81years (G 2). Methods: Of 1187 patients admitted with stroke during 5 years in our stroke unit, we included 252 patients with independent functional status (modified Rankin scale, [mRS] ≤ 2) before the stroke. All patients underwent clinical examination, blood test, electrocardiography, brain imaging, and cerebrovascular ultrasound. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - September 29, 2018 Category: Neurology Authors: Dolores Cocho, Sulema Yarleque, Anuncia Boltes, Jordi Espinosa, Jordi Ciurans, Claustre Pont-Sunyer, Jordi Pons Source Type: research

Effective Reserve: A Latent Variable to Improve Outcome Prediction in Stroke
Prediction of functional outcome after stroke based on initial presentation remains an open challenge, suggesting that an important aspect is missing from these prediction models. There exists the notion of a protective mechanism called brain reserve, which may be utilized to understand variations in disease outcome. In this work, we expand the concept of brain reserve (effective reserve) to improve prediction models of functional outcome after acute ischemic stroke (AIS). Consecutive AIS patients with acute brain magnetic resonance imaging ( (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - September 28, 2018 Category: Neurology Authors: Markus D. Schirmer, Mark R. Etherton, MD, PhD, Adrian V. Dalca, PhD, Anne-Katrin Giese, MD, Lisa Cloonan, MSc, Ona Wu, PhD, Polina Golland, PhD, Natalia S. Rost, MD, MPH, FAAN Source Type: research

A Population-Based Study of Intracerebral Hemorrhage Survivors ’ Outcomes
We evaluated 3-month neurologic, functional, cognitive, and quality of life (QOL) outcomes in intracerebral hemorrhage (ICH) overall, and by sex and ethnicity in a population-based study. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - September 28, 2018 Category: Neurology Authors: Julius Griauzde, Lynda D. Lisabeth, Chengwei Li, Brisa N. Sanchez, Erin Case, Nelda M. Garcia, Lewis B. Morgenstern, Darin B. Zahuranec Source Type: research

High Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio are Associated with Symptomatic Internal Carotid Artery Stenosis
The neutrophil to lymphocyte ratio (NLR) and the platelet to lymphocyte ratio (PLR) have been identified as predictive factors in several cardiovascular diseases but their significance in patients with internal carotid artery (ICA) stenosis is still poorly known. The aim of this study was to determine the clinical significance of the preoperative NLR and PLR in patients with ICA stenosis undergoing carotid endarterectomy. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - September 27, 2018 Category: Neurology Authors: Nicolas Massiot, Fabien Lareyre, Audrey Voury-Pons, Yann Pelletier, Julien Chikande, Joseph Carboni, Emilien Umbdenstock, Elix ène Jean-Baptiste, Réda Hassen-Khodja, Juliette Raffort Source Type: research

Uneventful Pregnancy and Delivery after Thrombolysis Plus Thrombectomy for Acute Ischemic Stroke: Case Study and Literature Review
We describe a case of an uneventful pregnancy and delivery after thrombolysis plus endovascular mechanical thrombectomy for acute ischemic stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - September 27, 2018 Category: Neurology Authors: Toshiyuki Tony Watanabe, Masahiko Ichijo, Tomoyuki Kamata Source Type: research

A Meta-analytic Study of Predictors for Informal Caregiver Burden in Patients With Stroke
Several studies have reported on predictors for caregiver burden in patients with stroke, but the magnitude of the impact of these variables remains unclear. The aim of the study was to determine the magnitude of relationship between each predictor and caregiver burden. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - September 26, 2018 Category: Neurology Authors: Wei Zhu, Yan Jiang Source Type: research

Increased Serum Alkaline Phosphatase in Patients with Acute Ischemic Stroke
Stroke is one of the most common causes of disability and death. Higher alkaline phosphatase (ALP) levels have been associated with poor functional outcomes and mortality in previous studies. We investigated alterations in serum ALP concentrations and functional outcomes in patients with acute ischemic stroke (AIS). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - September 26, 2018 Category: Neurology Authors: Yang Liu, Xue Liang, Xiaomin Xu, Meixue Dong, Shiyu Jia, Changqi Lu, Youdong Wei Source Type: research

Vertebrobasilar Dolichoectasia Causing Symptomatic Hydrocephalus Due to Third Ventricular Compression
Vertebrobasilar dolichoectasia sometimes presents with symptoms related to mass effect like cranial nerve palsies, or with ischemia or hemorrhage. Symptomatic hydrocephalus as a complication of vertebrobasilar dolichoectasia is extremely uncommon. Furthermore, there are few cases of vertebrobasilar dolichoectasia, in which cerebrospinal fluid flow disorder mechanisms are clearly demonstrated in neuroimaging findings. Here, we describe a patient with vertebrobasilar dolichoectasia who presented with symptomatic hydrocephalus due to direct compression against the third ventricle, which was immediately relieved by ventriculop...
Source: Journal of Stroke and Cerebrovascular Diseases - September 23, 2018 Category: Neurology Authors: Yumiko Oishi, Ryo Ueda, Yuki Kuranari, Tomoyuki Imanishi Source Type: research

Behavioral Effect of Short- and Long-Term Exercise on Motor Functional Recovery after Intracerebral Hemorrhage in Rats
In this study, we investigated the effects of short- and long-term exercise on motor functional recovery following intracerebral hemorrhage (ICH) in rats. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - September 22, 2018 Category: Neurology Authors: Keigo Tamakoshi, Kazuto Ishida, Keishi Hayao, Hideaki Takahashi, Hiroyuki Tamaki Source Type: research

Prognosis of Tandem Occlusions versus Isolated Intracranial Occlusions
Both acute single intracranial and tandem occlusions are managed with intravascular thrombectomy with success, but little evidence exists about the differences in their mid-term outcome. We aim to compare the outcome at 3 months after tandem (extracranial internal carotid and/or middle cerebral artery) and single intracranial (M1 division) occlusions, and to identify the factors, which determine such prognosis. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - September 22, 2018 Category: Neurology Authors: Claudia Rodr íguez-López, Federico Ballenilla Marco, Jaime Díaz Guzmán Source Type: research

Magnetic Resonance Imaging White Matter Hyperintensity as a Predictor of Stroke Recurrence in Patients with Embolic Stroke of Undetermined Source
This study aimed to investigate factors associated with stroke recurrence and new-onset atrial fibrillation (AF) in patients with embolic stroke of undetermined source (ESUS). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - September 21, 2018 Category: Neurology Authors: Satoru Kashima, Takahiro Shimizu, Hisanao Akiyama, Yasuhiro Hasegawa Source Type: research

Safety and Feasibility of Argatroban, Recombinant Tissue Plasminogen Activator, and Intra-Arterial Therapy in Stroke (ARTSS-IA Study)
A randomized trial of concurrent recombinant tissue-type plasminogen activator (r-tPA)  + thrombin-inhibition with Argatroban in stroke patients recently demonstrated safety and signal of efficacy compared to r-tPA alone, but patients having endovascular therapy (EVT) were excluded. The current study intended to study feasibility and safety of concurrent r-tPA and Argatroban in pa tients undergoing EVT. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - September 21, 2018 Category: Neurology Authors: Ketevan Berekashvili, Jazba Soomro, Loren Shen, Vivek Misra, Peng R. Chen, Spiros Blackburn, Mark Dannenbaum, James C. Grotta, Andrew D. Barreto Source Type: research

IMM-H004, a Novel Coumarin Derivative Compound, Inhibits H2O2-Induced Neurotoxicity via Antioxidant and Antiapoptosis in PC12 Cells
IMM-H004 [7-hydroxy-5-methoxy-4-methyl-3-(4-methylpiperazin-1-yl)-coumarin] is a novel derivative of coumarin, which played neuroprotective roles in brain ischemia in rats in previous studies. Although antiapoptosis and improving synapsis structure were proved, the effects and mechanisms of IMM-H004 in brain ischemia need further study. In this paper, the effect of IMM-H004 on H2O2-induced neurotoxicity in pheochromocytoma (PC12) cells was researched. Morphological observation, MTT method and PI/Hoechst staining were used to indicate cell viability and apoptosis. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - September 19, 2018 Category: Neurology Authors: Xiu-Yun Song, Jin-Feng Hu, Dong-Hui Wu, Hai-Jie Ji, Nai-Hong Chen Source Type: research

Using Smartphones to Collect Quantitative Data on Lower Limb Functionality in People Who Have Suffered a Stroke
The main objective was to use the inertial sensor integrated into a smartphone to collect quantitative data on lower limb functioning during execution of the timed up and go test and sit to stand test by people in the acute stage of stroke. The secondary objective was to analyze whether smartphones provide reliable quantitative data on performance of these functional tests. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - September 18, 2018 Category: Neurology Authors: Jose Antonio Merch án-Baeza, Manuel González-Sánchez, Antonio Ignacio Cuesta-Vargas Source Type: research

Stroke in Pregnancy and Review of Current Literature: Arterial Spin-Labeling MRI Can Identify the Presence and Intensity of Collateral Circle
We present a diagnostic strategy in a pregnant woman with suspect of acute stroke. We perform magnetic resonance with arterial spin labeling sequence, an X-ray and contrast medium safe perfusion technique. Arterial spin labeling can detects collateral vessels in patient with acute ischemic stroke. Demonstrating collateral vessels is relevant for better understanding prognosis and for improving the diagnostic assessment in pregnancy. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - September 15, 2018 Category: Neurology Authors: Agnese Morello, Tommaso Casseri, Maurizio Acampa, Paolo Galluzzi, Alfonso Cerase, Lucia Monti Source Type: research

Trends of Antiplatelet Therapy for the Management of Moyamoya Disease in Japan: Results of a Nationwide Survey
This study reports results of a nationwide survey conducted in 2016 on the trends of antiplatelet therapy for moyamoya disease in Japan. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - September 14, 2018 Category: Neurology Authors: Koichi Oki, Masahiro Katsumata, Yoshikane Izawa, Shinichi Takahashi, Norihiro Suzuki, Kiyohiro Houkin, Research Committee on Spontaneous Occlusion of Circle of Willis (Moyamoya disease) Source Type: research

Masthead
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - September 13, 2018 Category: Neurology Source Type: research

Editorial Board
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - September 13, 2018 Category: Neurology Source Type: research

Table of Contents
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - September 13, 2018 Category: Neurology Source Type: research