Outcomes for Patients With In-Hospital Stroke: A Multicenter Study From the Australian Stroke Clinical Registry (AuSCR)
The quality of care and outcomes for people who experience stroke whilst in hospital for another condition has not been previously studied in Australia. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - February 26, 2019 Category: Neurology Authors: Dominique A. Cadilhac, Monique F. Kilkenny, Natasha A. Lannin, Helen M. Dewey, Christopher R. Levi, Kelvin Hill, Brenda Grabsch, Rohan Grimley, David Blacker, Amanda G. Thrift, Sandy Middleton, Craig S. Anderson, Geoffrey A. Donnan, On behalf of the Austr Source Type: research

Utility of Minimum Apparent Diffusion Coefficient Ratios in Alberta Stroke Program Early CT Score Regions for Deciding on Stroke Therapy
Background and Purpose: Therapeutic indications for recombinant tissue plasminogen activator therapy and endovascular therapy need to be assessed for patients with hyperacute ischemic stroke. We investigated the relationship between the minimum apparent diffusion coefficient ratios in each Alberta Stroke Program Early CT Score region and reversible lesion in patients with hyperacute ischemic stroke receiving recombinant tissue plasminogen activator therapy and/or treated with endovascular therapy. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - February 22, 2019 Category: Neurology Authors: Yuta Maetani, Masahiro Nakamori, Eiji Imamura, Yosuke Ishii, Hiroshi Aihara, Yoshio Suyama, Shinichi Wakabayashi, Hirofumi Maruyama Source Type: research

Exogenous Netrin-1 Inhibits Autophagy of Ischemic Brain Tissues and Hypoxic Neurons via PI3K/mTOR Pathway in Ischemic Stroke
This study aims to investigate the effect of Netrin-1 on autophagy of ischemic brain tissues and hypoxic neurons. Methods: We constructed rat persistent middle cerebral artery occlusion model in vivo and constructed the Oxygen Glucose-Deprivation model in vitro. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - February 21, 2019 Category: Neurology Authors: Tianchi Tang, Dekun Gao, Xiaosheng Yang, Xuming Hua, Shiting Li, Hui Sun Source Type: research

Dexmedetomidine Protects Against Neurological Dysfunction in a Mouse Intracerebral Hemorrhage Model by Inhibiting Mitochondrial Dysfunction-Derived Oxidative Stress
Intracerebral hemorrhage (ICH) is a subtype of stroke with high disability and mortality. Dexmedetomidine (Dex) has been shown to provide neuroprotection in several neurological diseases. The aim of present study was to investigate the effects of Dex on ICH-induced neurological deficits and brain injury and the underlying mechanisms. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - February 20, 2019 Category: Neurology Authors: Jing Huang, Qiang Jiang Source Type: research

Multiple Cerebral Hemorrhagic Lesions Depicted by Susceptibility-Weighted Imaging in a Patient with Down Syndrome: Case Report
Our objective is to study a 53-year-old woman with Down syndrome presented with massive lobar hematoma in the left fronto-parietal lobe, and who underwent craniotomy and hematoma evacuation. Histopathological diagnosis of surgical specimen was amyloid angiopathy. Postoperative magnetic resonance studies were performed. The lesion this time showed mixed intensity on susceptibility-weighted imaging. In addition, multiple hypointense lesions were evident. An old previously unidentified hemorrhage in the right temporo-parietal lobe was accompanied by superficial cortical siderosis. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - February 20, 2019 Category: Neurology Authors: Kei Yanai, Yasuo Ishida, Hajime Nishido, Shinya Miyamoto, Kazuto Yamazaki, Katsumi Hoya Tags: Case Report Source Type: research

Platelet Surface CD62p and Serum Vitamin D Levels are Associated with Clopidogrel Resistance in Chinese Patients with Ischemic Stroke
Background: To explore the association of platelet activation markers, vitamin D, and antiplatelet drugs resistance in ischemic stroke patients. Methods: A total of 230 patients with ischemic stroke were enrolled in this study. Platelet aggregation, platelet activation marker (CD62p), and vitamin D were measured after 7-14 days of dual antiplatelet treatment (aspirin  + clopidogrel). All individuals were divided into a drug resistance group and a drug sensitive group according to the platelet maximum aggregation rate induced by antagonist adenosine diphosphate or arachidonic acid. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - February 20, 2019 Category: Neurology Authors: Bi-Chao Lu, Xiao-Jie Shi, Lin Liang, Na Dong, Zhi-Zhong Liu Source Type: research

Prevalence, Trajectory, and Predictors of Poststroke Fatigue among Ghanaians
Poststroke fatigue (PSF) is rife among stroke survivors and it exerts a detrimental toll on recovery from functional deficits. The burden of PSF is unknown in sub-Saharan Africa. We have assessed the prevalence, trajectory, and predictors of PSF among 60 recent Ghanaian stroke patients. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - February 20, 2019 Category: Neurology Authors: Fred S. Sarfo, Patrick Berchie, Arti Singh, Michelle Nichols, Maria Agyei-Frimpong, Carolyn Jenkins, Bruce Ovbiagele, On behalf of PINGS Study Investigators Source Type: research

Carotid Intima-Media Thickness and Carotid Plaque: A Pilot Study of Risk Factors in an Indigenous Nigerian Population
Risk factors for carotid intima-media thickness (cIMT) and carotid plaque (CP) differ by ethnicity; however, this is not well understood in some ethnic populations. This work examines the risk factors for cIMT and CP in an indigenous Nigerian population. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - February 15, 2019 Category: Neurology Authors: Ofonime N. Ukweh, Ernest U. Ekpo Source Type: research

Deep Venous Thrombosis with Decreased Cerebral Blood Flow to the Thalamus was Completely Restored by Factor Xa Inhibitor
Background: Cerebral venous thrombosis is rare and an uncommon cause of stroke and has diverse etiologies and varied clinical presentations. Here, we report 2 cases of deep cerebral venous thrombosis. Case Description: A 64-year-old woman presented with cerebral venous thrombosis due to a hypercoagulable state associated with ovarian tumor. On initial fluid-attenuated inversion recovery and diffusion-weighted imaging, there was a diffuse high-intensity lesion in the bilateral thalamus. Computed tomography angiography showed occlusion of the straight sinus, vein of Galen, and internal cerebral vein. (Source: Journal of Stro...
Source: Journal of Stroke and Cerebrovascular Diseases - February 14, 2019 Category: Neurology Authors: Yu Shimizu, Katsuhiro Tsuchiya, Hironori Fujisawa Tags: Case Report Source Type: research

Comments on: “A Meta-Analysis of the Association between Microrna-196A2 and Risk of Ischemic Stroke and Coronary Artery Disease in Asian Population”
Wang et al1 recently published a meta-analysis on the role of miR-146a polymorphism (rs11614913 T> C) and susceptibility to ischemic stroke and coronary artery disease (CAD) in Asian population and concluded that the recalled variant “may contribute to CAD susceptibility.” They showed the result related to the protective effect of CAD in homozygote model (CC versus TT, OR = .43, 95%CI = .39-.47, P (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - February 13, 2019 Category: Neurology Authors: Morteza Gholami, Mahsa Mohammad Amoli Tags: Letter to the Editor Source Type: research

Etiologic Evaluation of Ischemic Stroke in Young Adults: A Comparative Study between Two European Centers
Introduction: Identifying the cause of ischemic stroke in young adults is often difficult. Our objective was to compare the etiologic diagnostic strategy for ischemic stroke in young adults between 2 European centers and investigate the influence of workup variations in the diagnosed etiologies. Patients and Methods: We included patients aged 18-55 years admitted for ischemic stroke or transient ischemic attack to the stroke units of Santa Maria Hospital in Lisbon, Portugal, and Innsbruck University Hospital in Innsbruck, Austria, between 2014 and 2016. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - February 13, 2019 Category: Neurology Authors: Bernardo Crespo Pimentel, Johann Willeit, Thomas T öll, Stefan Kiechl, Teresa Pinho e Melo, Patrícia Canhão, Catarina Fonseca, José Ferro Source Type: research

Aortic Pulsatility Propagates Intracranially and Correlates with Dilated Perivascular Spaces and Small Vessel Compliance
Introduction: To test the hypotheses that changes in the aortic pulse-wave produced by arterial stiffening are (1) propagated into cerebral small vessels, (2) associated with reduced compliance of small cerebral arterial vessels, and (3) associated with the presence of dilated perivascular spaces (PVS). Methods: Fifteen volunteers and 19 patients with late-onset depression (LOD) were prospectively recruited, of which 6 fulfilled the criteria for treatment-resistant depression (TRD). Aortic pulse-wave velocity (PWV) was determined using Carotid-Femoral Doppler. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - February 13, 2019 Category: Neurology Authors: Owen Thomas, John Cain, Mehran Nasralla, Alan Jackson Source Type: research

Widening Time Disparities between Two Paradigms: Tama-REgistry of Acute Endovascular Thrombectomy
The objective of this study was to confirm the real-world status of 2 paradigms of transportation. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - February 13, 2019 Category: Neurology Authors: Keigo Shigeta, Takahiro Ota, Tatsuo Amano, Masayuki Ueda, Yuji Matsumaru, Yoshiaki Shiokawa, Teruyuki Hirano Source Type: research

Preclinical Carotid Atherosclerosis in Patients With Juvenile-Onset Mixed Connective Tissue Disease
This study investigated preclinical atherosclerosis in patients with juvenile mixed connective tissue disease (JMCTD), which is a chronic inflammatory disease with a varied phenotype. Mixed connective tissue disease (MCTD) has well known associations with other autoimmune diseases known to have increased risk of cardiovascular disease. However, the cardiovascular risk for patients with the juvenile form remains unclear. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - February 13, 2019 Category: Neurology Authors: Karolina Skagen, Siri Opsahl Hetlevik, Mahtab Zamani, Vibke Lilleby, Mona Skjelland Source Type: research

Self-Reported Body Weight Changes, Perceptions, and Weight Loss Techniques among Stroke Survivors
Background: Little is known about the body weight goals and trends of stroke survivors, despite evidence that overweight and obesity can negatively influence poststroke rehabilitation outcomes. Thus, the purpose of this study was to identify self-reported body weight trends over time in stroke survivors and nonstroke controls (>50 years old) and describe the methods used to attempt to achieve body weight goals. Methods: Self-reported body weight 1) at age 25 years, 2) 10 years prior to the current assessment, 3) 1 year prior to the current assessment, 4) current weight, and 5) age of heaviest body weight were collected ...
Source: Journal of Stroke and Cerebrovascular Diseases - February 13, 2019 Category: Neurology Authors: Jessica L. Kelleher, Paul Weiss, Amy D. Rodriguez, Joe R. Nocera, Monica C. Serra Source Type: research

Association between Mapuche Ethnicity and Stroke: A Case-Control Study
Background: There is evidence of a greater incidence of stroke in native populations and minorities. A total of 34% of the population in the Araucan ía Region is indigenous. The association between Mapuche ethnicity and stroke is unknown. The aim of the study was to estimate the magnitude of the association between Mapuche ethnicity and stroke occurrence in patients admitted to the Dr. Hernán Henríquez Aravena Hospital (HHHA) in Temuco, Chile . Methods: We performed an incident case–control-paired study with patients hospitalized with an acute stroke in the internal medicine service and controls ...
Source: Journal of Stroke and Cerebrovascular Diseases - February 13, 2019 Category: Neurology Authors: Álvaro Soto, Gladys Morales, Rosa Provoste, Fernando Lanas, Isabel Aliaga, Daniela Pacheco, Sergio Muñoz Source Type: research

Hemilingual Angioedema after Thrombolysis in a Patient on an Angiotensin II Receptor Blocker
We report a case of a 60-year-old male presenting with hyperacute ischemic stroke developing hemilingual edema after thrombolysis. He was previously maintained on an angiotensin II receptor blocker (ARB), losartan. The swelling resolved over 2 days with immediate administration of intravenous steroids and antihistamine drugs. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - February 13, 2019 Category: Neurology Authors: Jose Danilo Bengzon Diestro, Lady Scarlette Pacsi Sedano, Nikolai Gil Diwa Reyes, Maria Cristina Zarsadias San Jose Tags: Case Report Source Type: research

Efficacy of Direct Revascularization Surgery for Hemorrhagic Moyamoya Syndrome As a Late Complication of Cranial Irradiation for Childhood Craniopharyngioma
Moyamoya syndrome (MMS) is an uncommon late complication after cranial irradiation. Its hemorrhagic presentation from the associated pseudo-aneurysm is extremely rare, and the optimal management strategy is undetermined. We herein report a 36-year-old man who developed intraventricular hemorrhage from a pseudo-aneurysm at the extended left anterior choroidal artery as an abnormal collateral of MMS 30 years after surgical removal and cranial irradiation for childhood craniopharyngioma. Catheter angiography confirmed the diagnosis of MMS, and multiple pseudo-aneurysms were evident at the ipsilateral abnormal choroidal collat...
Source: Journal of Stroke and Cerebrovascular Diseases - February 13, 2019 Category: Neurology Authors: Yuya Kato, Miki Fujimura, Kenichi Sato, Hidenori Endo, Teiji Tominaga Tags: Case Report Source Type: research

Direct Aspiration versus Stent Retriever Thrombectomy for Acute Stroke: A Systematic Review and Meta-Analysis in 9127 Patients
Background: The two most common approaches to thrombectomy of emergent large vessel occlusion (direct aspiration and primary stent retriever thrombectomy) have been extensively studied; however, the detailed benefit and risk comparison is largely unknown. Objective: To conduct a systematic review and meta-analysis to compare radiographic and clinical outcomes between the use of primary stent retrievers and direct aspiration in management of acute ischemic stroke. Methods: PubMed database was searched for studies between September 1, 2012 and December 31, 2017 with acute ischemic stroke patients. (Source: Journal of Stroke ...
Source: Journal of Stroke and Cerebrovascular Diseases - February 13, 2019 Category: Neurology Authors: Christopher T. Primiani, Angel Chinea Vicente, Michael T. Brannick, Aquilla S. Turk, J Mocco, Elad I. Levy, Adnan H. Siddiqui, Maxim Mokin Source Type: research

Fragility Index in Randomized Controlled Trials of Ischemic Stroke
Objective: The fragility index (FI), a minimum number of events in 1 arm of a clinical trial required to revert the statistically significant result to nonsignificant, has recently been developed as an easy-to-understand novel metric to evaluate the robustness of randomized controlled trials (RCTs). Here, we evaluated the FI of RCTs in the field of neurology, particularly in studies of ischemic stroke. Methods: Previous literature published between June 1, 2012 and May 31, 2018 were reviewed from the MEDLINE database by the authors. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - February 12, 2019 Category: Neurology Authors: Kenichiro Sato, Tatsushi Toda, Atsushi Iwata Source Type: research

Masthead
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - February 9, 2019 Category: Neurology Source Type: research

Editorial Board
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - February 9, 2019 Category: Neurology Source Type: research

Table of Contents
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - February 9, 2019 Category: Neurology Source Type: research

Disparities in the Use of Intravenous t-PA among Ischemic Stroke Patients: Population-based Recent Temporal Trends
Objective: To explore a 5-year comparison of disparities in intravenous t-PA (IV t-PA) use among acute ischemic stroke (AIS) patients based on race, gender, age, ethnic origin, hospital status, and geographic location. Methods: We extracted patients ’ demographic information and hospital characteristics for 2010 and 2014 from the New York Statewide Planning and Research Cooperative System (SPARCS). We compared disparities in IV t-PA use among AIS patients in 2010 to that in 2014 to estimate temporal trends. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - February 8, 2019 Category: Neurology Authors: Mohammad A. Faysel, Jonathan Singer, Caroline Cummings, Dimitre G. Stefanov, Steven R. Levine Source Type: research

Corrigendum to Intracerebral Hemorrhage in Multiple Sclerosis: A Retrospective Cohort Study [Journal of Stroke and Cerebrovascular Diseases Volume 28, Issue 2, February 2019, Pages 267-275]
The authors regret that the author name for Enrique Leira was incorrect at the time of publishing. This is now been corrected. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - February 8, 2019 Category: Neurology Authors: Maryam Zulfiqar, Fares Qeadan, Asad Ikram, Mudassir Farooqui, Sarah P. Richardson, Christopher S. Calder, Syed A. Quadri, Puja Mathur, Corey Ford, Santiago Ortega-Gutierrez, Enrique Leira, Harry Snow, Joel N. Gonzalez, Atif Zafar Tags: Corrigendum Source Type: research

Tales from the Trips: A Qualitative Study of Timely Recognition, Treatment, and Transfer of Emergency Department Patients with Acute Ischemic Stroke
Background and Objectives: Acute Ischemic stroke (AIS) is a time-sensitive emergency and patients frequently present to, and are transferred from emergency departments (EDs). We sought to evaluate potential factors, particularly organizational, that may influence the timeliness of interfacility transfer for ED patients with AIS. Methods: We conducted semistructured interviews at 3 EDs that routinely transfer AIS patients. A structured interview guide was developed and piloted prior to use. Staff were asked about perceived facilitators and barriers to timely and high quality emergency care for patients with AIS who require ...
Source: Journal of Stroke and Cerebrovascular Diseases - February 7, 2019 Category: Neurology Authors: Mitchell Hayes, David Schlundt, Kemberlee Bonnet, Timothy J. Vogus, Sunil Kripalani, Michael T. Froehler, Michael J. Ward Source Type: research

Progressive Cerebral Ischemia and Intracerebral Hemorrhage after Indirect Revascularization for a Patient with Cerebral Proliferative Angiopathy
We previously reported a patient with cerebral proliferative angiopathy (CPA) who showed cerebral ischemia in resting and acetazolamide-stressed N-isopropyl-p-[123I] iodoamphetamine single-photon emission computed tomography (123I-IMP-SPECT). At onset, the patient was treated conservatively. However, during the 2 years following initial onset, his hemiparesis and aphasia had gradually aggravated and his IQ scores were markedly decreased. MRI revealed progressive vascular proliferation and brain atrophy. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - February 6, 2019 Category: Neurology Authors: Tomomi Kimiwada, Toshiaki Hayashi, Misaki Takahashi, Reizo Shirane, Teiji Tominaga Source Type: research

Design and Implementation of Structured Clinical Documentation Support Tools for Treating Stroke Patients
We describe the development of a customized structured clinical documentation “toolkit” that standardizes patient data collection to conform to Best Practices for treating patients with stroke. The toolkit collects patients’ demographic information, relevant score test measures, and captures information on disability, treatment, and outcomes. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - February 5, 2019 Category: Neurology Authors: Kelly Claire Simon, Richard Munson, Archie Ong, Fulvio R. Gil, Franco Campanella, Laura Hillman, Rebekah Lai, Richard Chesis, Samuel Tideman, Rosa Maria Vazquez, Steven Meyers, Roberta Frigerio, Demetrius Maraganore Source Type: research

The Influence of Stroke Location on Cognitive and Mood Impairment. A Voxel-Based Lesion-Symptom Mapping Study
Background and purpose: The role of stroke location as a determinant of mood and cognitive symptoms is still a matter of debate. The aim of this study was to identify the predictive value of ischemic stroke location, on a voxel basis, for mood and cognitive outcome. Materials and methods: A prospective monocentric study including patients with a supratentorial ischemic stroke was conducted. A 3 Tesla brain MRI was performed at baseline. Mood and cognition were assessed using Hospital Anxiety and Depression scale (HAD), apathy inventory (AI), and Montreal Cognitive Assessment scale subscores, performed at 3 months poststrok...
Source: Journal of Stroke and Cerebrovascular Diseases - February 1, 2019 Category: Neurology Authors: Sharmila Sagnier, Fanny Munsch, Antoine Bigourdan, Sabrina Debruxelles, Mathilde Poli, Pauline Renou, St éphane Olindo, François Rouanet, Vincent Dousset, Thomas Tourdias, Igor Sibon Source Type: research

Progressive Respiratory Muscle Training for Improving Trunk Stability in Chronic Stroke Survivors: A Pilot Randomized Controlled Trial
Background: Stroke weakens the respiratory muscles, which in turn may influence the trunk stability; it is unclear whether the progressive respiratory muscle training (RMT) is effective in improving the trunk stability. The aim of this study was to investigate the effects of progressive RMT with trunk stabilization exercise (TSE) on respiratory muscles thickness, respiratory muscle functions, and trunk stability in chronic stroke survivors. Methods: This is a pilot randomized controlled trial. Chronic stroke survivors (n = 33) who were able to sit independently participated in the tstudy. (Source: Journal of Stroke and Cer...
Source: Journal of Stroke and Cerebrovascular Diseases - January 31, 2019 Category: Neurology Authors: Kyeongbong Lee, Daesung Park, GyuChang Lee Source Type: research

The Comparison of Clinical Findings and Treatment Between Unilateral and Bilateral Vertebral Artery Dissection
Background: There are limited clinical studies of bilateral vertebral artery dissection (VAD). Objective: To compare the characteristics, imaging findings, and treatments between patients with bilateral and unilateral VAD. Methods: Between February 2007 and May 2017, 31 (mean age: 53.0 years; 23 men, 8 women) out of 171 VAD patients were hospitalized because of bilateral VAD. Onset type, dissection site, dominant side of the VA, imaging features, treatments, and outcomes were investigated based on medical records. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 31, 2019 Category: Neurology Authors: Masaki Takahara, Toshiyasu Ogata, Hiroshi Abe, Toshio Higashi, Takashi Morishita, Koichi Takano, Tooru Inoue Source Type: research

Secular Increases in Spontaneous Subarachnoid Hemorrhage during Pregnancy: A Nationwide Sample Analysis
Importance: Understanding of the epidemiology, outcomes, and management of spontaneous subarachnoid hemorrhage (sSAH) during pregnancy is limited. Small, single center series suggest a slight increase in morbidity and mortality. Objective: To determine if incidence of sSAH in pregnancy is increasing nationally and also to study the outcomes for this patient population. Design, Setting, and Participants: A retrospective analysis was performed utilizing the Nationwide Inpatient Sample (NIS) and Healthcare Cost and Utilization Project for the years 2002-2014 for sSAH hospitalizations. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 30, 2019 Category: Neurology Authors: Kaustubh Limaye, Achint Patel, Mihir Dave, Cynthia Kenmuir, Sourabh Lahoti, Ashutosh P. Jadhav, Edgar A. Samaniego, Santiago OrtegaGutierrez, James Torner, David Hasan, Colin P. Derdeyn, Tudor Jovin, Harold P. Adams, Enrique C. Leira Source Type: research

Transient Global Amnesia Secondary to Atherosclerotic Stenosis of Accessory Posterior Cerebral Artery
A 65-year-old woman was presented with a sudden onset of anterograde amnesia and iterative questioning after physical activity. Her past medical history included hypertension, diabetes, 2 symptomatic stroke events involving left temporal lobe infarction (Fig 1, A), and left basal ganglia infarction. There were no other positive neurological signs on this admission except for the previously right hemiparesis. At 3 days after onset, diffusion-weighted imaging (DWI) showed left hippocampal restricted diffusion foci (Fig 1, B). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 29, 2019 Category: Neurology Authors: Zhiyong Zhang, Zhiqin Liu, Dantao Peng Tags: Case Study Source Type: research

Hyperperfusion after Endovascular Reperfusion Therapy for Acute Ischemic Stroke
This study investigated the factors causing hyperperfusion and outcomes. Methods: We retrospectively analyzed 27 patients with AIS who underwent successful acute revascularization (TICI: Thrombolysis in Cerebral Infarction 2b  + 3). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 28, 2019 Category: Neurology Authors: Koji Shimonaga, Toshinori Matsushige, Masahiro Hosogai, Yukishige Hashimoto, Tatsuya Mizoue, Chiaki Ono, Kaoru Kurisu, Shigeyuki Sakamoto Source Type: research

Television Viewing Time and Stroke Risk: Australian Diabetes Obesity and Lifestyle Study (1999-2012)
Introduction: Having a low level of physical activity is an established risk factor for stroke, but little is known about the importance of common sedentary behavior —television viewing—to stroke risk. Methods: We conducted a retrospective analysis of data that were collected as part of the longitudinal Australian Diabetes, Obesity, and Lifestyle study. Stroke events reported during the study (between baseline assessment in 1999-2000 and April 2011) were con firmed using adjudication based on medical records. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 22, 2019 Category: Neurology Authors: Toby B. Cumming, Elizabeth Holliday, David Dunstan, Coralie English Source Type: research

Nicardipine Associated Risk of Short-Term Mortality in Critically Ill Patients with Ischemic Stroke
This study aimed to determine all-cause in-hospital mortality, medication-related hypotensive episodes, development of hospital acquired infections and hospital length of stay between nicardipine and labetalol use for the management of hypertension after acute ischemic stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 22, 2019 Category: Neurology Authors: Mahsa Sadeghi, Hamidreza Saber, Azara Singh, Claudia Hanni, Dennis Parker, Aaron Desai, Wazim Mohamed Source Type: research

Subarachnoid Hemorrhage with Progressive Cerebral Steno-Occlusive Disease: Report of 2 Cases
Nontraumatic nonaneurysmal subarachnoid hemorrhage (SAH) is a rare condition. Among them, SAH with cerebral steno-occlusive disease is quite rare. Moreover there has been no report of SAH patient who had been diagnosed with steno-occlusive disease since before. We here report 2 cases of nontraumatic nonaneurysmal convexity SAH who originally had progressive cerebral steno-occlusive disease. Case 1, a woman in her 40s who had diagnosed left internal carotid artery (ICA) stenosis 6 years before complained of headache. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 21, 2019 Category: Neurology Authors: Soichiro Takamiya, Tetsuyuki Yoshimoto, Katsuhiko Maruichi Tags: Case Report Source Type: research

Unraveling Specific Brain Microstructural Damage in Moyamoya Disease Using Diffusion Magnetic Resonance Imaging and Positron Emission Tomography
Chronic ischemia may induce brain microstructural damage and lead to neurocognitive dysfunction in patients with Moyamoya disease (MMD). We applied neurite orientation dispersion and density imaging (NODDI) and 15O-gas positron emission tomography (PET) to elucidate the specific ischemic brain microstructural damage of MMD in the cortex and the white matter. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 21, 2019 Category: Neurology Authors: Shoko Hara, Masaaki Hori, Ryo Ueda, Shihori Hayashi, Motoki Inaji, Yoji Tanaka, Taketoshi Maehara, Kenji Ishii, Shigeki Aoki, Tadashi Nariai Source Type: research

Serum Troponin Level in Acute Ischemic Stroke Identifies Patients with Visceral Infarcts
Background and Purpose: Patients with ischemic stroke of cardioembolic origin are at risk of visceral (renal or splenic) infarction. We hypothesized that serum troponin level at time of ischemic stroke would be associated with presence of visceral infarction. Methods: Data were abstracted from a single center prospective stroke database over 18 months and included all patients with ischemic stroke who underwent contrast-enhanced computerized tomography (CT) of the abdomen and pelvis for clinical purposes within 1 year of stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 18, 2019 Category: Neurology Authors: Idrees Azher, Ashutosh Kaushal, Andrew Chang, Shawna Cutting, Brian Mac Grory, Tina Burton, Katarina Dakay, Bradford Thompson, Michael Reznik, Linda Wendell, Nicholas Stevenson Potter, Ali Mahta, Shyam Rao, Maurizio Paciaroni, Mitchell S.V. Elkind, Mahesh Source Type: research

Serum Rheumatoid Factor Levels at Acute Phase of Ischemic Stroke are Associated with Poststroke Cognitive Impairment
Background: The effect of serum rheumatoid factor (RF) on poststroke cognitive impairment remains unknown. We aimed to investigate the association of serum RF in the acute phase with cognitive impairment at 3 months after ischemic stroke onset. Methods: Our study was based on a random sample from the China Antihypertensive Trial in Acute Ischemic Stroke, a total of 582 patients from 7 of 26 participating sites of the trial with serum RF levels were included in this analysis. Cognitive impairment was defined as Mini-Mental State Examination less than 27 or Montreal Cognitive Assessment less than 25. (Source: Journal of Stro...
Source: Journal of Stroke and Cerebrovascular Diseases - January 17, 2019 Category: Neurology Authors: Zhengbao Zhu, Lihua Chen, Daoxia Guo, Chongke Zhong, Aili Wang, Xiaoqing Bu, Tan Xu, Jianhui Zhang, Zhong Ju, Libing Guo, Jintao Zhang, Dong Li, Chung-Shiuan Chen, Jing Chen, Yonghong Zhang, Jiang He Source Type: research

A Puzzling Case of Cryptogenic Stroke
Background: Stroke is a common neurological complication of infective endocarditis (IE) and it is associated with increased morbidity and mortality but infective endocarditis in acute stroke setting is hard to discover. Material and methods: A 75-year-old man referred to hospital for the onset of left hemiparesis and dysarthria. His past medical history included hypertension. He had 3 months history of fatigue, fever, and weight loss. Neurological examination revealed left hemiparesis and dysarthria. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 17, 2019 Category: Neurology Authors: Marisa Distefano, Rosalinda Calandrelli, Vincenzo Arena, Alessandro Pedicelli, Giacomo Della Marca, Fabio Pilato Tags: Case Report Source Type: research

Risk of Stroke among Patients with Chronic Rhinosinusitis: A Systematic Review and Meta-analysis
Background: Recent studies have suggested that patients with chronic rhinosinusitis (CRS) may have a higher risk of stroke although the data are still limited. The current systematic review and meta-analysis was conducted with the aims to identify all studies that investigated this relationship and summarize their results together to better characterize the risk of stroke among patients with CRS. Methods: A comprehensive literature review was conducted by searching for published articles in MEDLINE and EMBASE databases from inception to October 2018 to identify all observational studies that compared the risk of stroke amo...
Source: Journal of Stroke and Cerebrovascular Diseases - January 17, 2019 Category: Neurology Authors: Phuuwadith Wattanachayakul, Pongprueth Rujirachun, Patompong Ungprasert Source Type: research

Early Motor-Behavioral Outcome of Ischemic Stroke with Ketogenic Diet Preconditioning: Interventional Animal Study
Background: Cerebral stroke, with ischemic stroke being its most common type, is the leading cause of chronic disability. The ketogenic diet has been used for treating seizures for centuries and has been considered to be a treatment for other neurologic diseases in recent years. The goal of this study is to evaluate the effects of ketogenic diet preconditioning on the early motor-behavior outcome of rats with induced cerebral ischemic stroke. Methods: Twenty-four rats were surveyed in 3 groups of Main, Control, and Sham. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 16, 2019 Category: Neurology Authors: Sheida Shaafi, Mirmohsen Sharifi-Bonab, Neda Ghaemian, Mohaddeseh Mokhtarkhani, Hossen Akbari Source Type: research

A Preliminary Study of the Association between Apolipoprotein E Promoter Methylation and Atherosclerotic Cerebral Infarction
Aim: To investigate association of Apolipoprotein E (ApoE) gene promoter methylation with atherosclerotic cerebral infarction (ACI) in the Han Chinese population. Methods: Twenty-six ACI patients (the case group) and 26 healthy (the control group) were recruited randomly from Henan Han nationality population, from April 2016 to August 2016. Bisulfite pyrosequencing technology was used to examine the role of the aberrant gene promoter methylation in ACI in Han Chinese population. Especially, we used the odds ratio and 95% confidence interval (95% CI) method to elevate the correlation between ApoE Promoter Methylation and AC...
Source: Journal of Stroke and Cerebrovascular Diseases - January 16, 2019 Category: Neurology Authors: Huili Zhang, Xinyu Zhao, Chongjian Wang, Ran Du, Xiaojie Wang, Jitong Fu, Qi Sun Source Type: research

Efficacy of Thyrotropin-Releasing Hormone Analog for Protracted Disturbance of Consciousness due to Aneurysmal Subarachnoid Hemorrhage
Objective: The efficacy of thyrotropin-releasing hormone tartrate (TRH-T) for treating prolonged disturbance of consciousness due to aneurysmal subarachnoid hemorrhage (SAH) remains unclear. The purpose of the present study was to determine whether TRH-T was really effective, and what was the recovery factor when it was valid. This was a retrospective study of a single facility. Methods: We treated 208 patients with aneurysmal SAH at our hospital between 2011 and 2017. Among them, we investigated 97 cases in which TRH-T was administered to prolonged disturbance of consciousness. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 16, 2019 Category: Neurology Authors: Ami Shibata, Fumihiro Matano, Yu Fujiki, Takayuki Mizunari, Yasuo Murai, Hiroyuki Yokota, Akio Morita Source Type: research

Contralateral Approach Based on a Preoperative 3-Dimensional Virtual Osteotomy Technique for Anterior Circulation Aneurysms
Objective: Our objective was to review 15 consecutive patients with anterior circulation aneurysms managed through a contralateral approach. Individualized surgical simulation using three-dimensional (3D) imaging was adopted to enable safe performance of clipping surgery. Methods: Five patients had multiple intracranial aneurysms, and 10 patients had a single aneurysm on the contralateral side of the craniotomy. Preoperatively, the unique architecture of aneurysms was fully understood in their 3-dimensionality reconstructed by Mimics software. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 16, 2019 Category: Neurology Authors: Haiyong He, Chuan Chen, Wensheng Li, Lun Luo, Cong Ling, Hui Wang, Zhuopeng Chen, Ying Guo Source Type: research

Clinical Characteristics of Borderzone Infarction in Egyptian Population
Objectives: In this research we wanted to highlight the importance of defining Borderzone infarctions (BZI) as a separate subtype in stroke classifications. We thus studied cases of isolated BZI, small vessel disease (SVD), and large vessel disease (LVD), to identify their points of similarities and difference in a sample of Egyptian patients. Methods: This is a cross-sectional (observational) study. Consecutive 637 acute ischemic stroke patients were recruited over a 2 year period, from 2 stroke units of Ain Shams University hospitals in Egypt. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 16, 2019 Category: Neurology Authors: Nevine El Nahas, Hossam Shokri, Osama Abdulghani, Magd Zakaria, Taha Kamel, Nagia Fahmi, Naglaa Khayat, Aly Shalash, Ahmed El Basiony, Ramez Reda, Sherine Farag, Mohamed Tork, Ahmed Elbokl, Ihab Abdelbaset, Hany Aref Source Type: research

Osteoprotegerin Assessment Improves Prediction of Mortality in Stroke Patients
Background: Elevated circulating osteoprotegerin (OPG) level is associated with an increased risk of hospitalization for ischemic stroke and coronary artery disease. The aim of the present study was to analyze whether OPG assessment may improve the prediction of mortality in patients with stroke. Patients and Methods: Serum OPG, fetuin A, 25-OH-D3, intact parathyroid hormone levels were assessed in serum samples which were left over after routine tests in a hospital laboratory. This assessment was conducted in 240 consecutive patients with acute ischemic stroke, admitted within 24 hours after the onset of symptoms to the S...
Source: Journal of Stroke and Cerebrovascular Diseases - January 15, 2019 Category: Neurology Authors: Jaros ław Wajda, Maciej Świat, Aleksander J. Owczarek, Michał Holecki, Jan Duława, Aniceta Brzozowska, Magdalena Olszanecka-Glinianowicz, Jerzy Chudek Source Type: research

Degree of Conjugate Gaze Deviation on CT Predicts Proximal Vessel Occlusion and May Expedite Endovascular Therapy
Purpose: Recent trials have demonstrated superior outcomes with combination IV-tPA and endovascular therapy (EVT) within 6 hours of symptom onset in patients with proximal vessel occlusion (ICA, M1, or proximal M1/M2) compared to IV-tPA alone. The current standard of diagnosis for consideration of EVT is CT angiogram (CTA). Unfortunately, not all hospitals are equipped with CTA, and the decision to transfer to tertiary centers is often based on nonenhanced CT. Ipsilateral conjugate gaze deviation (CGD) is associated with worse outcomes and larger infarcts in acute ischemic stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 14, 2019 Category: Neurology Authors: Nan N. Jiang, Crystal Fong, Demetrios J. Sahlas, Sandra Monteiro, Ramiro Larrazabal Source Type: research

Single-Centre Experience with Patients Selection for Mechanical Thrombectomy Based on Automated Computed Tomography Perfusion Analysis –A Comparison with Computed TomographyCT Perfusion Thrombectomy Trials
We present a single-center experience with CTP selection and comparison with CTP trials. Methods: Data of consecutive MT patients (from January 2016 to December 2017) were retrospectively reviewed. All patients with multiphase CT angiography confirmed the presence of anterior circulation large vessel occlusion/s in the intracranial internal carotid artery and/or middle cerebral artery (M1 or M2) and with admission brain CTP analyzed by RAPID software were included into the analysis. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 14, 2019 Category: Neurology Authors: Jiri Vanicek, Petra Cimflova, Martin Bulik, Jiri Jarkovsky, Veronika Prelecova, Viktor Szeder, Ondrej Volny Source Type: research