Susceptibility Vessel Sign in Deep Perforating Arteries in Patients with Recent Small Subcortical Infarcts
Recent small subcortical infarcts (RSSI) are the neuroimaging evidence of an acute infarction resulting from the occlusion of deep perforating arteries of the brain. RSSIs are considered one of the main radiological features of cerebral small vessel disease on magnetic resonance imaging (MRI), along with other chronic markers such as white matter hyperintensities (WMH), lacunae, cerebral microbleeds, enlarged perivascular spaces, and brain atrophy.1 The pathophysiology of cerebral small vessel disease is still unknown, but many mechanisms seem to be implied, such as arteriosclerosis, hypoperfusion, blood-brain barrier leak...
Source: Journal of Stroke and Cerebrovascular Diseases - October 31, 2020 Category: Neurology Authors: Salvatore Rudilosso, Marta Olivera, Diana Esteller, Carlos Laredo, Sergio Amaro, Laura Llull, Arturo Ren ú, Víctor Obach, Víctor Vera, Alejandro Rodríguez, Jordi Blasco, Antonio López-Rueda, Xabier Urra, Ángel Chamorro Source Type: research

Pre-hospital Diagnosis of Large Vessel Occlusion in Patients Being Transported by Helicopter
During the helicopter transportation of patients suspected of large vessel occlusion (LVO), an accurate and rapid decision-making process is required. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 31, 2020 Category: Neurology Authors: Yusuke Sugimura, Tokunori Ikeda, Seigo Shindo, Satoshi Namitome, Masatomo Miura, Kuniyasu Wada, Yoichiro Nagao, Yoshinori Yamanouchi, Tadashi Terasaki, Makoto Nakajima Source Type: research

Movement Disorders in Chronic Kidney Disease – A Descriptive Review
The objective of this study is to describe the mechanism of damage to subcortical structures in chronic kidney disease (CKD) and to describe the range of movement disorders associated with CKD. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 31, 2020 Category: Neurology Authors: Yasaman Safarpour, Nosratola D. Vaziri, Bahman Jabbari Source Type: research

Intracranial hemorrhage in hospitalized SARS-CoV-2 Patients: A Case Series
The SARS-CoV-2 virus causing Coronavirus Disease 2019 (COVID-19) is a global pandemic with almost 30 million confirmed worldwide cases. Prothrombotic complications arising from those affected with severe symptoms have been reported in various medical journals. Currently, clinical trials are underway to address the questions regarding anticoagulation dosing strategies to prevent thrombosis for these critically ill patients. However, given the increasing use of therapeutic anticoagulation in patients admitted with COVID-19 to curtail this prothrombotic state, our institution has witnessed six cases of devastating intracrania...
Source: Journal of Stroke and Cerebrovascular Diseases - October 31, 2020 Category: Neurology Authors: Fady Mousa-Ibrahim, Stephanie Berg, Oluwatobi Odetola, Michael Teitcher, Sean Ruland Source Type: research

Acute Cerebrovascular Disorders and Vasculopathies associated with Significant Mortality in SARS-CoV-2 patients admitted to the Intensive Care Unit in The New York Epicenter
We present a case series of consecutive COVID-19 patients with cerebrovascular disease treated at our institution including 3 cases of cerebral artery dissection including subarachnoid hemorrhage. Knowledge of the varied presentations including dissections will help treating clinicians at the bedside monitor and manage these complications preemptively. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 31, 2020 Category: Neurology Authors: Fawaz Al-Mufti, Christian Becker, Haris Kamal, Hussein Alshammari, Vincent Dodson, Rolla Nuoman, Katarina Dakay, Jared Coper, Edwin Gulko, Gurmeen Kaur, Ramandeep Sahni, Corey Scurlock, Stephan A. Mayer, Chirag D. Gandhi Source Type: research

Carotid Atherosclerosis and Patent Foramen Ovale in Embolic Stroke of Undetermined Source
Carotid atherosclerosis and likely pathogenic patent foramen ovale (PFO) are two potential embolic sources in patients with embolic stroke of undetermined source (ESUS). The relationship between these two mechanisms among ESUS patients remains unclear. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 30, 2020 Category: Neurology Authors: George Ntaios, Dimitrios Sagris, Davide Strambo, Kalliopi Perlepe, Gaia Sirimarco, Georgios Georgiopoulos, Stefania Nannoni, Eleni Korompoki, Efstathios Manios, Konstantinos Makaritsis, Konstantinos Vemmos, Patrik Michel Source Type: research

A Novel Mutation Outside of the EGFr Encoding Exons of NOTCH3 Gene in a Chinese with CADASIL
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary cerebral small vascular disease caused by the mutations of the NOTCH3 gene. The NOTCH3 gene consists of 33 exons. The pathogenic mutations of the NOTCH3 gene in CADASIL are located in 2 –24 exons coding for the 34 EGFr (epidermal growth factor-like repeat) domains. The classical clinical manifestations are recurrent TIA or ischaemic stroke, migraine, cognitive disorder and affective disorder. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 30, 2020 Category: Neurology Authors: wan Wang, Zhixia Ren, yingying Shi, Jiewen Zhang Source Type: research

Moyamoya Disease Associated with Graves ’ Disease and Down Syndrome: A Case Report and Literature Review
Moyamoya vessels (MMV) are cerebral vasculopathies characterized by the formation of net-like collateral vessels at the cerebral basal area and stenosis of the terminal internal carotid artery (ICA), proximal middle cerebral artery (MCA), and anterior cerebral artery (ACA). Moyamoya disease (MMD) is diagnosed when these MMVs occur bilaterally.1,2 (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 29, 2020 Category: Neurology Authors: Hikaru Nakamura, Kei Sato, Shota Yoshimura, Yukishige Hayashi, Tsuyoshi Izumo, Yoshiharu Tokunaga Source Type: research

Addressing Stroke Literacy in Nigeria Through Music: A Qualitative Study of Community Perspectives
The incidence of stroke in Nigeria is unknown, but stroke literacy, defined here as awareness of stroke warning symptoms and risk factors may be poor in high-risk communities. Although there is growing recognition of the use of music as a conduit to promote health literacy, African music is often overlooked as a source of health information. We sought to understand community-level perspectives on using African music to promote acute stroke literacy. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 29, 2020 Category: Neurology Authors: Ucheoma Nwaozuru, Chizoba Ezepue, Juliet Iwelunmor, Chisom Obiezu-Umeh, Florida Uzoaru, Daudet Ilunga Tshiswaka, Njideka Okubadejo, Randall Edgell, Oliver Ezechi, Titilola Gbajabiamila, Adeola Z. Musa, David Oladele, Olugbenga Ogedegbe, Olajide Williams Source Type: research

Homocysteine is Associated with the Development of Cerebral Small Vessel Disease: Retrospective Analyses from Neuroimaging and Cognitive Outcomes
Cerebral small vessel disease (cSVD) includes a wide spectrum of pathological, neuroimaging, and clinical processes with various aetiologies that affect small arteries, arterioles, capillaries, and venules of the brain.1 With the intensified aging trend of the population, increased use of brain magnetic resonance imaging (MRI) has revealed heavy cSVD burdens, contributing to about 25% of ischaemic strokes, most haemorrhagic strokes, and nearly half of dementia cases in the world.2 Usually occult in onset, cSVD progresses slowly but finally induces complex consequences, posing a tough challenge to clinical management. (Sour...
Source: Journal of Stroke and Cerebrovascular Diseases - October 29, 2020 Category: Neurology Authors: Yifan Ji, Xiangyu Li, Zhenjie Teng, Xiaosha Li, Wei Jin, Pei yuan Lv Source Type: research

Prevalence of Worsening Problems Using Post-Stroke Checklist and Associations with Quality of Life in Patients with Stroke
Stroke is the most common cause of adult disability worldwide.1,2 Stroke survivors suffer from various kinds of motor and non-motor problems, which hinders participation in daily activities.3,4 Without proper resolution of these problems, they can result in worsening of health-related quality of life (HRQoL).5 However, long-term post-stroke care has not been standardized yet,6 and stroke survivors have reported that health systems are not responsive to their changing needs.7 Therefore, long-term stroke follow-up should address a broad range of post-stroke medical and HRQoL –related problems with scheduled reassessmen...
Source: Journal of Stroke and Cerebrovascular Diseases - October 29, 2020 Category: Neurology Authors: Hyo Won Im, Won-Seok Kim, SeungYeun Kim, Nam-Jong Paik Source Type: research

Thrombectomy for Stroke Caused by Cardiac Myxoma
Large vessel occlusion stroke, caused by cardiac myxoma, is a rare and severe condition with poor neurological outcomes. Currently, there are no clear guidelines for treating patients with this condition. In our case, we describe a rare case of acute ischemic stroke caused by cardiac myxoma which was successfully treated with mechanical thrombectomy. At the end of a 6 months' follow-up, her National Institutes of Health Stroke Scale score (NIHSS) had significantly improved, from 20 to 3. This result is encouraging and suggests that mechanical thrombectomy may be a feasible therapy for large vessel occlusion stroke induced ...
Source: Journal of Stroke and Cerebrovascular Diseases - October 29, 2020 Category: Neurology Authors: Biao Zhou, Shanshan Huang, Shuyun Liu, Lijie Ren, Can Huang, Zongde Lian Tags: Case Report Source Type: research

Endovascular Treatment Decision Making in Patients with Low Baseline ASPECTS: Insights from UNMASK EVT, an International Multidisciplinary Study
Endovascular therapy is a highly effective treatment for acute ischemic stroke (AIS) due to large vessel occlusion (LVO)1 and now considered standard of care.2 In most randomized EVT trials, patients with low Alberta Stroke Program Early CT Score (ASPECTS) scores were either excluded or underrepresented. Hence, current European and North American guidelines for the early management of patients with acute ischemic stroke restrict level 1A recommendations for endovascular therapy (EVT) to patients with baseline ASPECTS score>5. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 29, 2020 Category: Neurology Authors: Johanna Maria Ospel, Ravinder Singh, Nima Kashani, Mohammed Almekhlafi, Alexis Wilson, Urs Fischer, Bruce Campbell, Shinichi Yoshimura, Francis Turjman, Pillai Sylaja, Ji-Hoe Heo, Michael D. Hill, Gustavo Saposnik, Mayank Goyal, Bijoy Menon Source Type: research

Recurrent Cerebral Venous Thrombosis Treated with Direct Oral Anticoagulants in a Japanese Man with Hereditary Protein C Deficiency
We herein report a case involving a 32-year-old Japanese man with recurrent cerebral venous thrombosis due to hereditary protein C deficiency. He was admitted to our hospital with impaired consciousness. Brain magnetic resonance imaging demonstrated high intensities diffusely along the bilateral sulci and magnetic resonance venography revealed left transverse sinus and superior sagittal sinus stenoses. His father had a history of cerebral infarction and venous thrombosis. The protein C activity level examined by chromogenic synthetic substrate assay was markedly reduced. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 29, 2020 Category: Neurology Authors: Kazuyuki Saito, Kazuyuki Ishii, Konosuke Furuta, Masaki Kobayashi, Yoshiaki Wada, Eriko Morishita Tags: Case Report Source Type: research

First-Line Contact Aspiration vs Stent Retriever for Proximal Occlusion in Acute Ischemic Stroke: A Systemic Review and Meta-Analysis
In recent years, multiple clinical trials have laid the foundations of mechanical thrombectomy therapy in ischemic stroke caused by large vessel occlusion.1 And the vast majority of the researches employed stent retrievers. However, advances in mechanical thrombectomy devices provide us more options.2 Direct aspiration illustrated as forced arterial suction thrombectomy (FAST) and the latter a direct aspiration first-pass technique (ADAPT) was carried out as more flexible catheters with a large bore size became available. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 27, 2020 Category: Neurology Authors: Xiangyuan Zhang, Xiong Guo, Yunqiang Yi, Chuanbin Cheng, Aitang Liang, Dongli Pu, Junjie Jiang Source Type: research

Modifiable Factors Associated with Non-Adherence to Secondary Ischaemic Stroke Prevention Strategies
Eighty percent of stroke is due to five modifiable factors: hypertension, smoking, abdominal obesity, unhealthy diet, and lack of exercise.1 Risk factors for first-time and recurrent ischaemic stroke are similar.2 The absolute risk of a recurrent ischaemic stroke following an initial ischaemic stroke is 29.7% by five years.3 Recurrent strokes are associated with greater disability and mortality than first-time strokes.4 Secondary prevention strategies are key in reducing recurrent ischaemic events. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 27, 2020 Category: Neurology Authors: G Shankari, Szu Chyi Ng, Si Ying Goh, Fung Peng Woon, Kinjal Doshi, Pei Shieen Wong, Qianqian Fan, Il Fan Tan, Kaavya Narasimhalu, Deidre Anne De Silva Source Type: research

Corrigendum to “Comparative Analysis of Fibrinolytic Properties of Alteplase, Tenecteplase and Urokinase in an in Vitro Clot Model of Intracerebral Haemorrhage. [Journal of Stroke and Cerebrovascular Diseases, Vol. 29, No. 9 (September), 2020: 105073]”
The authors regret an error in the author list, and this should appear as above. The authors regret any inconvenience caused. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 27, 2020 Category: Neurology Authors: Naureen Keric, Melanie Doebel, Harald Krenzlin, Elena Kurz, Yasemin Tanyildizi, Axel Heimann, Jochem Koenig, Oliver Kempski, Florian Ringel, Julia Masomi-Bornwasser Source Type: research

Management of Ischemic Stroke Following Left Ventricular Assist Device
Acute ischemic stroke is a common complication and an important source of morbidity and mortality in patients with left ventricular assist devices. There are no standardized protocols to guide management of ischemic stroke among patients with left ventricular assist device. We evaluated our experience treating patients who had an acute ischemic stroke following left ventricular assist device placement. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 24, 2020 Category: Neurology Authors: Leigh A. Rettenmaier, Aayushi Garg, Kaustubh Limaye, Enrique C. Leira, Harold P. Adams, Amir Shaban Source Type: research

Covid-19 and major organ thromboembolism: manifestations in neurovascular and cardiovascular systems.
COVID-19, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been shown to cause multisystemic damage. We undertook a systematic literature review and comprehensive analysis of a total of 55 articles on arterial and venous thromboembolism in COVID-19 and articles on previous pandemics with respect to thromboembolism and compared the similarities and differences between them. The presence of thrombosis in multiple organ systems points to thromboembolism being an integral component in the pathogenesis of this disease. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 24, 2020 Category: Neurology Authors: Presaad Pillai, Joyce Pauline Joseph, Nurul Huda Mohamad Fadzillah, Masliza Mahmod Tags: Review Article Source Type: research

Fatal Brain Injury Following Carbon Dioxide Angiography
Carbon dioxide (CO2) as a contrast agent has been in use as early as the 1920s for visualization of retroperitoneal structures. Digital subtraction angiography (DSA) using CO2 as a contrast agent for vascular imaging was developed in the 1980s. Currently, CO2  angiography is an alternative agent in patients with chronic kidney disease (CKD) and those who are at risk of developing contrast-induced nephropathy. However, CO2 causes neurotoxicity if the gas inadvertently enters the cerebrovascular circulation leading to fatal brain injury. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 23, 2020 Category: Neurology Authors: Madihah Hepburn, Naresh Mullaguri, Anusha Battineni, Dhimant Dani, Pravin George, Christopher R. Newey Source Type: research

Disease Burden Following Non-Cardioembolic Minor Ischemic Stroke or High-Risk TIA: A GWTG-Stroke Study
We examined outcomes and Medicare payments following any severity IS or TIA as well as the subgroup with minor IS or high-risk TIA. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 23, 2020 Category: Neurology Authors: Brystana G. Kaufman, Shreyansh Shah, Anne S. Hellkamp, Barbara L. Lytle, Gregg C. Fonarow, Lee H. Schwamm, Eva Les én, Jonatan Hedberg, Amarjeet Tank, Edmond Fita, Narinder Bhalla, Nipun Atreja, Janet Prvu Bettger Source Type: research

Low Hemoglobin Levels are Associated with Sarcopenia, Dysphagia, and Adverse Rehabilitation Outcomes After Stroke
Anemia and sarcopenia are common concern in geriatric care. There is extensive evidence of an association between adverse health outcomes and anemia.1 –3 Anemia has been associated with poor physical performance and disability, frailty, deterioration in quality of life, and increase in mortality rate in community-dwelling older adults.1,4–6 Concurrently, sarcopenia is common in older adults and is associated with relatively poor outcomes. Appr oximately 10% of community-dwelling older adults are affected by sarcopenia, which is associated with increased risk of falls and fractures, physical dependency, malnutri...
Source: Journal of Stroke and Cerebrovascular Diseases - October 23, 2020 Category: Neurology Authors: Yoshihiro Yoshimura, Hidetaka Wakabayashi, Fumihiko Nagano, Takahiro Bise, Sayuri Shimazu, Ai Shiraishi Source Type: research

Recurrent Pontine Strokes in a Young Male
A 34-year-old patient presented to the emergency department with recurrent neurologic symptoms of sudden onset. MRI showed white matter hyperintensities consistent with small vessel disease, predominantly in the pons. There were no known cardiovascular risk factors (CVRF) and extensive workup for vasculitis was negative. The preliminary diagnosis was small vessel primary central nervous system vasculitis, but immunosuppressive treatment did not stop a progression of the disease over 6 months. Repeated negative diagnostic workup for vasculitis, lack of response to therapy, young age, and predominant involvement of the pons ...
Source: Journal of Stroke and Cerebrovascular Diseases - October 22, 2020 Category: Neurology Authors: Marcus Grobe-Einsler, Horst Urbach, Sebastian Paus Tags: Case Report Source Type: research

Attempt to delineate occluded arteries with initial plain computed tomography in acute cerebral arterial occlusion
Several randomized controlled trials have investigated the effects of endovascular thrombectomy using stent retrievers for acute cerebral arterial occlusion.1 –4 Endovascular thrombectomies have generally proceeded without anatomical information regarding the affected intracranial arteries, and this could cause complications such as vessel perforation.5–7 Several recent studies have visualized occluded arteries using various imaging modalities, includ ing three-dimensional computed tomography (CT) angiography,8 magnetic resonance imaging (MRI),9,10 and cone-beam CT. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 22, 2020 Category: Neurology Authors: Jouji Kokuzawa, Yasuhiko Kaku, Nozomi Sasaki, Kiyomitsu Kano, Naoki Oka, Akihide Matsuda, Yousuke Sasaki Source Type: research

Protective Effect of Eichhornia Crassipes Against Cerebral Ischemia Reperfusion Injury in Normal and Diabetic rats
Eichhornia crassipes (EC) is well reported to modify inflammatory response, oxidative stress which are key pathophysiological finding of cerebral reperfusion injury, alongside it is reported to reduce cholesterol and blood glucose levels, and therefore present work was designed to investigate the effect of EC on cerebral reperfusion injury in normal and diabetic rats. Each protocol comprised cerebral ischemia (CI) for 30 min followed by reperfusion(R) for 1  h. Animals were treated with EC (100 mg/kg p.o) for seven days. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 21, 2020 Category: Neurology Authors: Vashisth Bhavsar, Jitendra Vaghasiya, B N Suhagia, Priyanshu Thaker Source Type: research

D-dimer and its Combination with Blood Lipid on Prognosis of Patients with Acute Ischemic Stroke
Previous studies indicate that the levels of d-dimer and blood lipids at admission affect the prognosis of patients with acute ischemic stroke (AIS), however, whether there is a dose-response effect of d-dimer on prognosis, or a combined effect of d-dimer with blood lipids on prognosis, remains unclear. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 21, 2020 Category: Neurology Authors: Jiamin Wang, Anqi Feng, Jia Xu, Yue Liu, Fang Li, Yanyan Sun, Hongwei Sun, Fan Yang, Jingbo Zhao, Ying Tang Source Type: research

Fabry Disease in Young Ischemic Stroke Patients in Northern Israel
The prevalence of Fabry Disease (FD) with cerebrovascular complications varies in different populations. The aim of this study was to estimate the presence of FD among young stroke patients in northern Israel. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 21, 2020 Category: Neurology Authors: S. Afanasiev, G. Telman, R. Hadad, G. Altarescu Source Type: research

Retrospective Analysis of 28 Cases Confirmed for Primary Angiitis of the Central Nervous System by Biopsy
The present study aimed to summarize the clinical characteristics, therapeutic effects, and long-term prognosis of cases confirmed with primary angiitis of the central nervous system (PACNS) by biopsy, analyze the risk factors, and provide clinical guidance for the diagnosis and treatment of the disease. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 21, 2020 Category: Neurology Authors: Hong-Bo Chang, Ming Gao, Jian-Ning Zhang, Wei-Dong Cao, Sheng-Li Guo, Peng Wang, Gang Cheng, Hu-Lin Zhao Source Type: research

Apparent Treatment Resistant Hypertension Among Stroke Survivors in Ghana
There are limited data evaluating the characteristics of apparent treatment-resistant hypertension (aTRH) among stroke survivors in sub-Saharan Africa. We aimed to conduct a comparative analysis of the frequency and factors associated with aTRH among stroke survivors and stroke-free individuals with hypertension in Ghana. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 21, 2020 Category: Neurology Authors: Fred Stephen Sarfo, Bruce Ovbiagele Source Type: research

Challenges in Brain Death Determination and Apnea Testing for Patients with COVID-19
Apnea testing remains essential for the clinical evaluation of brain death determination. In patients who test positive for SARS-CoV-2, disconnecting the patient from the ventilator and introducing high flow oxygen into the endotracheal tube increases the risk for aerosolization of airway secretions and exposure of the examiner. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 21, 2020 Category: Neurology Authors: Yazan Radaideh, Rajeev Garg, Amina A. Abdalla, Ankeet D Patel, Sayona John, Ivan Da Silva Source Type: research

Hydrocephalous as a Complication of Perimesencephalic Nonaneurysmal Subarachnoid Hemorrhage
JLSM, male, 71 years old, admitted into a private hospital in the city of Joinville, Brazil, complaining of persistent and severe headache. The patient reported onset of the condition three days before, after sexual activity, associated with nausea, vomiting and dizziness. He has a medical history of epilepsy, under regular use of Phenobarbital. The physical examination evidenced slight nuchal rigidity. Cranial computed tomography (CT) showed subarachnoid hemorrhage (SAH) in cisterns around the brainstem (Fig. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 20, 2020 Category: Neurology Authors: Guilherme Zini Reis, Fernanda Subtil de Moraes Machado, Wladimir Kummer de Paula, Fl ávio Diniz Ribas, Felipe Ibiapina dos Reis Tags: Case Report Source Type: research

Feasibility of a Nurse-Trained, Family Member-Delivered Rehabilitation Model for Disabled Stroke Patients in Rural Chongqing, China
This study aimed to evaluate the feasibility of a novel nurse-trained, family member-delivered rehabilitation model for disabled stroke patients in rural southwest China. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 20, 2020 Category: Neurology Authors: Kun Chu, Xiaoqing Bu, Zhenxing Sun, Yuan Wang, Wenqin Feng, Li Xiao, Fuyan Jiang, Xiaojun Tang Source Type: research

Embolization with Stent-Assisted Technique for Wide-Necked Extremely Small Intracranial Aneurysm with Diameter no more than 2  mm
To investigate the safety and efficacy of embolization with stent-assisted technique for wide-necked extremely small intracranial aneurysms (ESIAs) with diameter no more than 2 mm. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 20, 2020 Category: Neurology Authors: Qi Tian, Wei Dong, Wei Zhang, Zhou Xu, Junmin Wang, Qianxue Chen, Mingchang Li Source Type: research

Multicentric Experience with an Intermediate Aspiration Catheter for Distal M2 Ischemic Stroke
To assess technical and clinical outcomes of an intermediate bore aspiration catheter (AXS Catalyst 5; Stryker) as front-line therapy for M2-M3 acute occlusions. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 20, 2020 Category: Neurology Authors: Daniele Giuseppe Romano, Giulia Frauenfelder, Antonio Caragliano, Vittorio Semeraro, Antonio Pitrone, Alessio Bozzi, Francesco Diana, Orazio Buonomo, Sofia Vidali, Roberto Gandini, Renato Saponiero, Sergio Vinci Source Type: research

Acute Internal Carotid Artery Occlusion Long after Carotid Revascularization by Vein Graft
We report the case of a 27-year-old woman with acute internal carotid artery occlusion long after carotid artery revascularization by vein graft. She presented with sudden unconsciousness and left hemiparesis. Her right carotid artery was revascularized with an ipsilateral internal jugular vein graft during a carotid body tumor resection 10 years ago. Computed tomography angiography revealed a right internal carotid artery terminus occlusion. Intravenous rt-PA and mechanical thrombectomy were performed, resulting in successful recanalization. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 20, 2020 Category: Neurology Authors: Ryota Tamura, Nobuyuki Ohara, Yasutaka Murakami, Hirotoshi Imamura, Nobuyuki Sakai, Nobuo Kohara Tags: Case Report Source Type: research

Medical management of chronic subdural hematoma with tranexamic acid
We read with great interest the research work by Kutty RK and colleagues1 on medical management with Tranexamic Acid (TXA) for chronic subdural hematoma (CSDH). We appreciate the authors for successfully demonstrating a possible role for TXA in non-surgical management of CSDH with hematoma volumes ranging from as small as 25mL up to a volume of 350mL. That oral TXA use ranging from 27-120 days after diagnosis of CSDH provides resolution of hematoma with no complications is a novel contribution to knowledge; nevertheless we have a few suggestions on patient inclusion and methodology of the study. (Source: Journal of Stroke ...
Source: Journal of Stroke and Cerebrovascular Diseases - October 20, 2020 Category: Neurology Authors: Varun Suresh, Saurabh Sharma Tags: Letter to the Editor Source Type: research

Robot-assisted Gait Training Using Welwalk in Hemiparetic Stroke Patients: An Effectiveness Study with Matched Control
This study aimed to investigate the effectiveness of gait training using Welwalk in hemiparetic stroke patients in a real clinical setting. Materials and Methods: This prospective study included 36 hemiparetic stroke patients who underwent gait training using Welwalk. We examined the walking ability improvement efficiency using Functional Independence Measure (FIM)-walk as the primary outcome, which was compared with that of 36 patients (matched control group) who underwent conventional rehabilitation. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 19, 2020 Category: Neurology Authors: Takuma Ii, Satoshi Hirano, Shigeo Tanabe, Eiichi Saitoh, Junya Yamada, Masahiko Mukaino, Makoto Watanabe, Shigeru Sonoda, Yohei Otaka Source Type: research

Cerebral Venous Sinus Thromboses in Patients with SARS-CoV-2 Infection: Three Cases and a Review of the Literature
: Early studies suggest that acute cerebrovascular events may be common in patients with coronavirus disease 2019 (COVID-19) and may be associated with a high mortality rate. Most cerebrovascular events described have been ischemic strokes, but both intracerebral hemorrhage and rarely cerebral venous sinus thrombosis (CVST) have also been reported. The diagnosis of CVST can be elusive, with wide-ranging and nonspecific presenting symptoms that can include headache or altered sensorium alone. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 19, 2020 Category: Neurology Authors: Felix Nwajei, Pria Anand, Mohamad Abdalkader, Vanesa C. Andreu Arasa, Hugo J. Aparicio, Siavash Behbahani, Gioacchino Curiale, Ali Daneshmand, Hormuzdiyar Dasenbrock, Thomas Mayo, Asim Mian, Thanh Nguyen, Charlene Ong, J. Rafael Romero, Osamu Sakai, Court Source Type: research

Carotid Webs in Pediatric Acute Ischemic Stroke
Carotid web is a radiographic entity located in the posterior aspect of the origin of the internal carotid arteries, considered to be a pathologic equivalent to intimal fibromuscular dysplasia, and has been implicated in acute ischemic strokes. The mechanism underlying its development is unknown and it remains unclear if this lesion is congenital or acquired. The aim of our study was to determine the frequency of carotid webs in a pediatric population with acute ischemic stroke (AIS). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 17, 2020 Category: Neurology Authors: Sara Hassani, Raul G. Nogueira, Alhamza R. Al-Bayati, Selina Kala, Bryan Philbrook, Diogo C. Haussen Source Type: research

Effect of Modified Constrain Induced Movement Therapy on Fatigue and Motor Performance in Sub Acute Stroke
There is a little available information about the fatigue status among people receiving modified constraint induced movement therapy. The study examined such changes. The effect of using restraint on motor performance was also evaluated in sub acute phase after stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 17, 2020 Category: Neurology Authors: Wassim Mushtaq, Nusrat Hamdani, Majumi M. Noohu, S Raghavan Source Type: research

The Risk Factors for Death within 6 Months After Ischemic Stroke in Patients with Cancer
While the intravenous recombinant tissue plasminogen activator (rt-PA) therapy for acute ischemic stroke patients with cancer is recommended when survival of ≥ 6 months is expected, the risk factors for death and stroke recurrence within 6 months after stroke are not well known. Thus, we aimed to identify markers for death and recurrence risks within six months from stroke onset in patients with cancer. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 16, 2020 Category: Neurology Authors: Yoko Tsuchihashi, Takahiro Shimizu, Hisanao Akiyama, Yuta Hagiwara, Kaima Soga, Naoki Takao, Kenji Uchino, Toshiyuki Yanagisawa, Junji Yamauchi, Tomoo Sato, Yasuhiro Hasegawa, Yoshihisa Yamano Source Type: research

Identification of Patients with Nontraumatic Intracranial Hemorrhage Using Administrative Claims Data
Administrative claims datasets based on data captured for the purposes of billing are commonly used for health services and outcomes research as well as public health surveillance.1 –3 Although administrative claims offer the potential to study very large populations in a cost effective manner by providing a large amount of information in a standardized format, the data often lack clinical accuracy given the vague coding of symptoms or diagnoses.3,4 While the introduction of the International Classification of Disease version 10 (ICD-10) codes into administrative claims data sought to rectify the challenge of classif...
Source: Journal of Stroke and Cerebrovascular Diseases - October 15, 2020 Category: Neurology Authors: Rohit B. Sangal, Samah Fodeh, Andrew Taylor, Craig Rothenberg, Emily B. Finn, Kevin Sheth, Charles Matouk, Andrew Ulrich, Vivek Parwani, John Sather, Arjun Venkatesh Source Type: research

Acute Spinal Cord Infarction with Preferential Involvement of Ventral Gray Matter: An Autopsy Report
Herein, we report abdominal aortic thrombosis as a rare cause of acute spinal cord infarction. A 78-year-old man with multiple vascular risk factors developed acute paraplegia with sensory and urinary disturbances and signs of ischemia in both lower limbs. The post-mortem study done 3 days after the onset of symptoms revealed a large coagulum in the abdominal aorta, distal to the renal arteries and extending to bilateral common iliac arteries; in addition, marked atherosclerosis was present in most large blood vessels. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 15, 2020 Category: Neurology Authors: Shuta Toru, Tetsuo Yamada, Masako Suzuki, Akira Takemoto, Tomonari Amano, Masanobu Kitagawa, Takayoshi Kobayashi, Toshiki Uchihara Tags: Case Report Source Type: research

Characteristics and Outcomes of Patients who Refuse Intravenous Thrombolysis for Acute Ischemic Stroke - The San Diego Experience
Intravenous Thrombolysis (IV rt-PA) is administered in (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 14, 2020 Category: Neurology Authors: Tara von Kleist, Dawn Meyer, Karen Rapp, Brett Cowan Meyer, Royya Modir Source Type: research

A Case Report of Wall-Eyed Bilateral Internuclear Ophthalmoplegia with Bilateral Facial Palsy
Case reports of bilateral facial palsy with horizontal gaze restriction are rare. A 62-year-old woman experienced sudden onset of bilateral adduction deficits, bilateral abducting nystagmus accompanied with facial diplegia. We confirmed acute ischemic stroke in the midline dorsal pons, where medial longitudinal fasciculus (MLF) and facial nerve fascicles are located. This can be explained by vascular variation of pontine perforating arteries. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 14, 2020 Category: Neurology Authors: Kayeong Im, Hyunjin Ju, Mina Lee, Hakjae Roh Tags: Case Report Source Type: research

Management of Stroke in Patients with Left Ventricular Assist Devices
The number of patients with left ventricular assist devices (LVAD) is rapidly growing in industrialized countries. While cerebrovascular events comprise a significant complication, data on stroke etiology, clinical management and functional outcome are scarce. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 14, 2020 Category: Neurology Authors: Antje Giede-Jeppe, Sebastian S. Roeder, Kosmas Macha, Hagen B. Huttner, Stefan T. Gerner, Kilian Fr öhlich, Christian Heim, Stefan Schwab, Bernd Kallmuenzer Source Type: research

Subdural Hematoma: Predictors of Outcome and a Score to Guide Surgical Decision-Making
This study was designed to assess the benefit of surgical evacuation of SDH, identify predictors of functional outcome, and create a bedside score to guide the clinical management of SDH. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 14, 2020 Category: Neurology Authors: Richa Sharma, Eva Rocha, Marco Pasi, Hang Lee, Aman Patel, Aneesh B. Singhal Source Type: research

Comprehensive Use of Dynamic Electrical Neurostimulation and Botulinum Toxin Therapy in Patients with Post-Stroke Spasticity
Acute cerebrovascular accident poses a threat to the health of the nation. Dynamic electric neurostimulation decreases the excitability of the receptor apparatus, optimize microcirculatory processes, analgesic and antispasmodic effects. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 14, 2020 Category: Neurology Authors: Stanislav G Abramovich, Viktor A. Drobyshev, Anna E. Pyatova, Alexei V. Yumashev, Elizaveta S. Koneva Source Type: research

Tic Movement of Thyroid Cartilage as a Cause for Localized Cerebral Embolism: Mimics of Embolic Stroke of Undetermined Source with Non-Stenotic Carotid Plaque
Non-stenotic carotid plaques with stable appearance are not accepted as likely embolic source in the general criteria of embolic stroke of undetermined source (ESUS)1. Here, we reported a localized cerebral embolism from a thin, apparently stable non-stenotic carotid plaque caused by violent abnormal tic movement of thyroid cartilage under controlled dyslipidemia. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 14, 2020 Category: Neurology Authors: Akira Hanazono, Yui Sanpei, Sachiko Kamada, Wakana Sato, Masazumi Matsuda, Takahiro Otani, Masashiro Sugawara, Katsunori Iijima Tags: Case Report Source Type: research

Association between Low-Density Lipoprotein Cholesterol Levels and Proximal Single Subcortical Infarction in Comparison with Distal Single Subcortical Infarction
Single subcortical infarction (SSI) is one of the neuroimaging manifestations of cerebral small vessel disease (CSVD).1,2 According to the reports by Fisher and Caplan during 1960s to 1980s,3 –6 it has been classified into two pathological subtypes in the territory of penetrating arteries, either microatheroma or lipohyalinosis. Microatheroma, which usually affects the proximal segment of penetrating arteries with a diameter of 200 to 400 μm, containing fatty macrophages or foam-cell s in autopsy. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 14, 2020 Category: Neurology Authors: Hefei Tang, Yu Wang, Aichun Cheng, Anxin Wang, Jie Xu, Changqing Zhang, Xingquan Zhao, Yongjun Wang Source Type: research