Aerobic Training Efficacy in Inflammation, Neurotrophins, and Function in Chronic Stroke Persons: A Randomized Controlled Trial Protocol
Background: Neuroinflammation is an important part of stroke pathophysiology and has both detrimental and beneficial effects after stroke. Besides that the enhancement of neurotrophins seems to be related to improvements in stroke recovery. Evidences suggest that exercise plays a role in modulating anti-inflammatory and neurotrophic effects. However, little is known about its impact in stroke survivors, mainly in chronic stroke. The purpose of this study is to investigate the efficacy of moderate-intensity treadmill exercise in changing inflammatory mediators, interleukin-6 (IL-6), soluble tumor necrosis factor receptors I...
Source: Journal of Stroke and Cerebrovascular Diseases - November 10, 2018 Category: Neurology Authors: Daniela Matos Garcia Oliveira, Larissa Tavares Aguiar, Marcus Vin ícius de Oliveira Limones, Aline Gonçalves Gomes, Luana Cristina da Silva, Christina Danielli Coelho de Morais Faria, Paula Luciana Scalzo Source Type: research

Vagal Nerve Palsy After Transarterial Embolization of Transverse-Sigmoid Dural Arteriovenous Fistula Using Onyx
We report a case of a 70-year-old man who developed a transverse-sigmoid dural arteriovenous fistula (TS-DAVF) that was successfully treated by transarterial embolization (TAE) with Onyx. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 10, 2018 Category: Neurology Authors: Sadayoshi Watanabe, Ichiro Nakahara, Tsuyoshi Ohta, Shoji Matsumoto, Ryota Ishibashi, Izumi Nagata Source Type: research

Positional Vertigo After Isolated Cerebellar Nodulus Stroke: A Report of 3 Cases
We report 3 cases (69-year-old man, 71-year-old man, and 82-year-old woman) of isolated cerebellar nodulus stroke patients, who presented with positional vertigo alone that lasted only for 2-4 days. Brain magnetic resonance imaging helped diagnosing these cases. Although rare, clinicians should be aware of isolated cerebellar nodulus stroke, when facing with patients with paroxysmal vertigo of acute onset. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 10, 2018 Category: Neurology Authors: Fuyuki Tateno, Ryuji Sakakibara Source Type: research

The Hippocratic Doctrine of “the Acute Brain Suffering” as the Brain Stroke
Background: The ancient Greek term "apoplexy" as is repeatedly mentioned by the Hippocratic School of Medicine, included a cluster of diseases, mainly those concerning the central nervous system. The term was wrongfully infiltrated in Western European medicine as synonymous to what is called today a "stroke" of the brain. Objective: While in "Corpus Hippocraticum" the definition of the stroke was rather ambiguous; our study aims to unveil those fragments referring to it, in order to compose the Hippocratic theory of what it stood for "Acute Brain Suffering" (Greek: Οξ&epsi...
Source: Journal of Stroke and Cerebrovascular Diseases - November 9, 2018 Category: Neurology Authors: Gregory Tsoucalas, Theodore G Papaioannou, Marianna Karamanou Source Type: research

Effect of Stride Management Assist Gait Training for Poststroke Hemiplegia: A Single Center, Open-Label, Randomized Controlled Trial
Poststroke gait disorders negatively impact activities of daily living. Rehabilitation for stroke patients is aimed at improving their walking ability, balance, and quality of life. Robot-assisted gait training (RAGT) is associated with an increased number of task-specific exercises, which may benefit poststroke motor learning. We investigated the effects of RAGT using Stride Management Assist (SMA, which increases walk ratio by inducing hip-joint flexion and extension) in subacute stroke patients with hemiplegia. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 9, 2018 Category: Neurology Authors: Naojiro Tanaka, Shinro Matsushita, Yasushi Sonoda, Yoshikatsu Maruta, Yuta Fujitaka, Masashi Sato, Miki Simomori, Rhyuki Onaka, Keiji Harada, Takashi Hirata, Shoji Kinoshita, Takatsugu Okamoto, Hitoshi Okamura Source Type: research

Risk Factors for Hemorrhagic and Cardioembolic Complications of Intracerebral Hemorrhage Associated with Anticoagulants
This study investigated hemorrhagic and cardioembolic events and risk factors in intracerebral hemorrhage patients taking anticoagulants. Methods: The clinical data of 65 consecutive intracerebral hemorrhage patients taking anticoagulants were retrospectively reviewed. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 8, 2018 Category: Neurology Authors: Sho Osawa, Tatsuya Shimizu, Tadashige Kano, Ryosuke Shintoku, Hiroya Fujimaki, Ken Asakura Source Type: research

The Influence of Weather on the Incidence of Primary Spontaneous Intracerebral Hemorrhage
Intracerebral hemorrhage has been associated with changes in various weather conditions. The primary aim of this study was to examine the collective influence of temperature, barometric pressure, and dew point temperature on the incidence of primary spontaneous intracerebral hemorrhage (sICH). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 8, 2018 Category: Neurology Authors: Rajeev Kumar Garg, Bichun Ouyang, Vishal Pandya, Raquel Garcia-Cano, Ivan Da Silva, Deborah Hall, Sayona John, Thomas Pritchett Bleck, Max Berkelhammer Source Type: research

The Role of Personalized Virtual Reality in Education for Patients Post Stroke —A Qualitative Case Series
Background: Education is essential to promote prevention of recurrent stroke and maximize rehabilitation; however, current techniques are limited and many patients remain dissatisfied. Virtual reality (VR) may provide an alternative way of conveying complex information through a more universal language. Aim: To develop and conduct preliminary assessments on the use of a guided and personalized 3D visualization education session via VR, for stroke survivors and primary caregivers. Methods: Four poststroke patients and their 4 primary caregivers completed the 3D visualization education session as well as pre- and postinterve...
Source: Journal of Stroke and Cerebrovascular Diseases - November 8, 2018 Category: Neurology Authors: Angelica G Thompson-Butel, Christine T Shiner, John McGhee, Benjamin John Bailey, Pascal Bou-Haidar, Michael McCorriston, Steven G Faux Source Type: research

Hospital Quality Metrics: “America's Best Hospitals” and Outcomes After Ischemic Stroke
Background: Developing quality metrics to assess hospital-level care and outcomes is increasingly popular in the United States. The U.S. News& World Report ranking of “America's Best Hospitals” is an existing, popular hospital-profiling system, but it is unknown whether top-ranked hospitals in their report have better outcomes according to other hospital quality metrics such as the Centers for Medicare and Medicaid Services (CMS) publicly reported 30-day stro ke measures. Methods: The analysis was based on the 2015-2016 U.S. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 8, 2018 Category: Neurology Authors: Judith H. Lichtman, Erica C. Leifheit, Yun Wang, Larry B. Goldstein Source Type: research

Impact of Elevated Hemoglobin A1c Levels on Functional Outcome in Patients with Acute Ischemic Stroke
Background: The association between hemoglobin A1c (HbA1c) and clinical outcomes of acute ischemic stroke is uncertain. We aimed to evaluate the association between initial hemoglobin A1c level and clinical outcome after acute ischemic stroke.Methods: A total of 408 patients with first-ever acute ischemic stroke were included in this study. We divided the patients into three groups according to HbA1c level: low HbA1c level (HbA1c (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 8, 2018 Category: Neurology Authors: Hong Wang, Yifan cheng, Siyan Chen, Xianmei Li, Zhenguo Zhu, Wanli Zhang Source Type: research

Persistent Primitive Olfactory Artery as Novel Collateral Channel to the Anterior Cerebral Artery in Moyamoya Disease
Background: There are a variety of collateral routes to compensate persistent cerebral ischemia in moyamoya disease. However, there is no report presenting the persistent primitive olfactory artery (POA) as a spontaneous collateral route to the anterior cerebral artery (ACA) in moyamoya disease. Methods: We precisely examined cerebral angiography in 84 patients with moyamoya disease to identify the collateral channel through the persistent POA. Its anatomy was evaluated on pre- and postoperative angiography. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 6, 2018 Category: Neurology Authors: Tetsuhiro Kamo, Haruto Uchino, Hisayasu Saito, Daina Kashiwazaki, Naoki Akioka, Naoya Kuwayama, Satoshi Kuroda Source Type: research

Patients with Acute Lacunar Infarction Have Benefit from Intravenous Thrombolysis
Introduction: Usefulness of intravenous thrombolysis in patients with acute lacunar cerebral infarction is questionable. The aim of this study was to evaluate the efficacy and safety of intravenous thrombolysis in patients with lacunar infarction in comparison with patients with nonlacunar infarction as well as with patients with lacunar infarction who were not treated with intravenous thrombolysis. Materials and methods: In the first part of the study, among patients with acute ischemic stroke treated with intravenous thrombolysis, characteristics and outcomes of 46 patients with lacunar and 221 patients with nonlacunar i...
Source: Journal of Stroke and Cerebrovascular Diseases - November 6, 2018 Category: Neurology Authors: Zeljko Zivanovic, Marina Gubi, Dmitar Vlahovic, Marija Milicevic, Mirjana Jovicevic, Aleksandra Lucic, Svetlana Ruzicka-Kaloci, Biljana Radovanovic, Tamara Rabi Zikic, Marija Zarkov, Nemanja Popovic, Petar Slankamenac Source Type: research

Carotid Artery-Related Perioperative Stroke Following Anterior Cervical Spine Surgery: A Series of 3 Cases and Literature Review
Vascular complications following anterior cervical spine surgery are rare but potentially devastating. Complications associated with the carotid artery are even more disastrous but largely anecdotal, with no more than 4 reported cases. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 6, 2018 Category: Neurology Authors: Yue-Qi Du, Wan-Ru Duan, Zan Chen, Hao Wu, Feng-Zeng Jian Source Type: research

The Impact of Covert Lacunar Infarcts and White Matter Hyperintensities on Cognitive and Motor Outcomes After Stroke
In addition to overt stroke lesions, co-occurring covert lesions, including white matter hyperintensities (WMH) and covert lacunar infarcts (CLI), contribute to poststroke outcome. The purpose of this study was to examine the relationship between covert lesions, and motor and cognitive outcomes in individuals with chronic stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 5, 2018 Category: Neurology Authors: Angela M. Auriat, Jennifer K. Ferris, Sue Peters, Joel Ramirez, Sandra E. Black, Claudia Jacova, Lara A. Boyd Source Type: research

Subcutaneous Heparin Therapy for Patients with Cancer-Associated Stroke
Anticoagulation therapy, particularly subcutaneous heparin therapy, is recommended for cancer-associated thrombosis. However, not starting or discontinuing anticoagulation was not rare. The aim of the present study was to examine the practical issues related to anticoagulation therapy and effects of subcutaneous heparin therapy for cancer-associated stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 5, 2018 Category: Neurology Authors: Hiroyuki Kawano, Yuko Honda, Tatsuo Amano, Haruko Okano, Rieko Suzuki, Masataka Torii, Yoshiko Unno, Yoshiaki Shiokawa, Teruyuki Hirano Source Type: research

Angiotensinogen M235T Gene Polymorphism is a Genetic Determinant of Cerebrovascular and Cardiopulmonary Morbidity in Adolescents with Sickle Cell Disease
Cerebrovascular stroke is a common critical complication of sickle cell disease (SCD). Angiotensinogen (AGT) M235T gene polymorphism is associated with risk of ischemic stroke and cardiovascular disease. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 5, 2018 Category: Neurology Authors: Mohsen Saleh ElAlfy, Fatma Soliman Elsayed Ebeid, Tarek Mostafa Kamal, Deena Samir Eissa, Eman Abdel Rahman Ismail, Samar Hassan Mohamed Source Type: research

Reduced Doses of Direct Oral Anticoagulants in Ischemic Stroke Patients with Nonvalvular Atrial Fibrillation
Background: The choice of standard or reduced doses of direct oral anticoagulants (DOACs) depends on patients ’ age, body weight, and renal function based on package instructions. Our aim was to conduct a simulation of DOAC dose using patients’ data obtained on admission. Methods: This retrospective study included 314 ischemic stroke patients with nonvalvular atrial fibrillation admitted to our hospital between September 2014 and February 2018. Data on age, body weight, creatinine, and creatinine clearance were collected for each subject, and simulation was conducted for the dose of each DOAC. (Source: Journal ...
Source: Journal of Stroke and Cerebrovascular Diseases - November 3, 2018 Category: Neurology Authors: Ichiro Deguchi, Masaki Takao Source Type: research

Residual Shunt after Patent Foramen Ovale Device Closure in Patients With Cryptogenic Stroke: Serial Bubble Contrast Transesophageal Echocardiography Data
Percutaneous closure of patent foramen ovale (PFO) is an alternative option to medical treatment for secondary prevention for cryptogenic stroke (CS). Despite technical success of procedure, residual shunt (RS) which is a presumable cause for recurrent stroke is observed in some patients. We evaluated the RS with serial follow-up bubble contrast transesophageal echocardiography (BCTEE) after PFO closure. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 3, 2018 Category: Neurology Authors: Jeonggeun Moon, Minsu Kim, Pyung Chun Oh, Dong Hoon Shin, Hyeon-MI Park, Youn Yi Jo, Ji Sung Lee, Woong Chol Kang Source Type: research

Early Magnetic Resonance Imaging Decreases Hospital Length of Stay in Patients with Ischemic Stroke
Imaging modalities are important part of stroke evaluation. Noncontrast head computed tomography (CT) is the initial imaging modality in acute stroke and although important to rule out acute hemorrhage and making a decision on thrombolytic treatment, ischemic changes may not be visible on CT for up to 24 hours. Magnetic resonance imaging (MRI) brain is an invaluable tool to confirm an ischemic stroke and facilitates stroke evaluation. Objective of this study was to investigate the correlation between time to MRI and length of hospital stay. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 3, 2018 Category: Neurology Authors: Bharti Manwani, Subhendu Rath, Nora S. Lee, Ilene Staff, Christoph Stretz, Janhavi Modak, Pasquale F. Finelli Source Type: research

Left Ventricular Ejection Fraction and Clinically Defined Heart Failure to Predict 90-Day Functional Outcome After Ischemic Stroke
Heart failure (HF) is a risk factor for atrial fibrillation (AF), stroke, and post-stroke disability. However, differing definitions and application of HF-criteria may impact model prediction. We compared the predictive ability of left ventricular ejection fraction (LVEF), a readily available objective echocardiographic index, with clinical HF definitions for functional disability and AF in stroke patients. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 2, 2018 Category: Neurology Authors: Yi Li, Timothy P. Fitzgibbons, David D. McManus, Richard P. Goddeau, Brian Silver, Nils Henninger Source Type: research

Neuroimaging Findings in Intracranial Sarcoid Phlebitis: A Case Report
Venous phlebitis in Neurosarcoidosis (NS) is rare but is often associated with intracranial hemorrhage (ICH). Imaging findings in such cases have been recently described on susceptibility weighted imaging (SWI). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 2, 2018 Category: Neurology Authors: Girish Bathla, Sudeepta Dandapat, Neetu Soni, Ravishankar P. Maheshwarappa Source Type: research

Vernet's Syndrome Associated with Internal Jugular Vein Thrombosis
Our objective is to present a case of Vernet's syndrome (cranial nerve (CN) IX, X, and XI palsy) associated with cerebral venous thrombosis (CVT) in an internal jugular vein. The patient presented with acutely developed dysphagia. The weakness of the left sternocleidomastoid and trapezius muscles was observed. The initial magnetic resonance imaging and computed tomography (CT) with contrast enhancement showed contrast-filling defect in the left internal jugular vein inside the jugular foramen. The magnetic resonance venography with contrast enhancement revealed a partial filling defect in the left sigmoid sinus and total o...
Source: Journal of Stroke and Cerebrovascular Diseases - November 2, 2018 Category: Neurology Authors: Myungah Lee, Youngjae Heo, Taewon Kim Source Type: research

Skiing Associated Stroke: Causes, Treatment, and Outcome
Previous studies have described ischemic stroke temporally related to specific triggers, but only 1 series collected patients with acute ischemic stroke (AIS) following downhill skiing and all caused by cervical artery dissections. Here we describe our series of AIS temporally associated to ski practice, focusing on the frequency, pathogenesis, clinical presentation, and prognosis. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 1, 2018 Category: Neurology Authors: Davide Strambo, Gaia Sirimarco, Nuno In ácio, Ashraf Eskandari, Patrick Michel Source Type: research

Endovascular Treatment of Ruptured Tiny Intracranial Aneurysms with Low-Profile Visualized Intraluminal Support Device
Background: Ruptured tiny intracranial aneurysms (TIAs) have been challenging both for endovascular and neurosurgical interventions. Thus, we aimed to evaluate the safety and efficacy of low-profile visualized intraluminal support (LVIS) device in the treatment of ruptured TIAs (rTIAs). Material and Methods: Among 761 intracranial aneurysms which were treated either surgically or endovascularly, 32 rTIAs underwent stent-assisted coiling with LVIS device between 2014 and 2017. Patient data were reviewed retrospectively. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 1, 2018 Category: Neurology Authors: Pei Wu, Pinar Eser Ocak, Dianhong Wang, Umut Ocak, Shancai Xu, Yuchen Li, Tongyu Zhang, Huaizhang Shi Source Type: research

The Impacts of Peptic Ulcer on Functional Outcomes of Ischemic Stroke
This study aimed to evaluate the impacts of peptic ulcer on functional outcomes of ischemic stroke. Methods: Patients with first-ever ischemic stroke were grouped as with and without history of peptic ulcer. Functional outcomes were evaluated with modified Rankin scale at 90 days after the index stroke. Favorable functional outcomes were defined as with a modified Rankin scale score of 0-2. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 1, 2018 Category: Neurology Authors: Zongliang Xu, Huamei Wang, Ying Lin, Qijin Zhai, Wen Sun, Zhaojun Wang, Zusen Ye, Hao Zhang, Shenghua Li, Kunxiong Yuan, Xinfeng Liu, Junrong Li, Gelin Xu Source Type: research

No Weekend or After-Hours Effect in Acute Ischemic Stroke Patients Treated by Telemedicine
Background: Stroke outcomes have been shown to be worse for patients presenting overnight and on weekends (after-hours) to stroke centers compared with those presenting during business hours (on-hours). Telemedicine (TM) helps provide evaluation and safe management of stroke patients. We compared time metrics and outcomes of stroke patients who were assessed and received intravenous recombinant tissue plasminogen activator (IV-tPA) via TM during after-hours with those during on-hours. Methods: Analysis of our TM registry from September 2015 to December 2016, identified 424 stroke patients who were assessed via TM and recei...
Source: Journal of Stroke and Cerebrovascular Diseases - November 1, 2018 Category: Neurology Authors: TC Cossey, Amanda Jagolino, Christy Ankrom, Arvind B. Bambhroliya, Chunyan Cai, Farhaan S. Vahidy, Sean I. Savitz, Tzu-Ching Wu Source Type: research

Reduced Serum Adiponectin Level and Risk of Poststroke Depression in Patients with Ischemic Stroke
Background and Aims: Decreased adiponectin  (APN) level has been indicated to be associated with depression. In the present study, we aimed to investigate whether serum APN could predict poststroke depression (PSD) at 3 months in patients with acute ischemic stroke. Method: Patients with first-ever ischemic stroke and hospitalized within 24 hours of symptoms onset were enrolled prospectively during March 2017 to September 2017. Serum APN level was measured at admission by enzyme-linked immunosorbent assay. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 1, 2018 Category: Neurology Authors: Junhua Yang, Guanghui Du, Jinyu Wang, Jia Chen, Chenghui Yang, Jia Li, Yun Zhang Source Type: research

Ischemic Stroke due to Virologically-Confirmed Varicella Zoster Virus Vasculopathy: A Case Series
Background: Limited data are available regarding the characteristics and prognosis of patients with stroke due to varicella zoster virus (VZV) vasculopathy. Methods: We studied 4 patients (2 men and 2 women; age, 38-63 years) from a single center who developed acute ischemic stroke due to VZV vasculopathy. The virological diagnosis was confirmed by detecting VZV DNA and/or the IgG antibody to VZV in the cerebrospinal fluid. Results: Three patients were taking immunosuppressive agents, including prednisolone and/or methotrexate, at baseline. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 1, 2018 Category: Neurology Authors: Takao Hoshino, Sono Toi, Kunio Toda, Yumiko Uchiyama, Hiroshi Yoshizawa, Mutsumi Iijima, Yuko Shimizu, Kazuo Kitagawa Source Type: research

Differential Expression of Vascular Endothelial Growth Factor-A165 Isoforms Between Intracranial Atherosclerosis and Moyamoya Disease
Vascular endothelial growth factor-A165 (VEGF-A165) has been identified as a combination of 2 alternative splice variants: proangiogenic VEGF-A165a and antiangiogenic VEGF-A165b. Intracranial atherosclerotic disease (ICAD) and moyamoya disease (MMD) are 2 main types of intracranial arterial steno-occlusive disorders with distinct capacities for collateral formation. Recent studies indicate that VEGF-A165 regulates collateral growth in ischemia. Therefore, we investigated if there is a distinctive composition of VEGF-A165 isoforms in ICAD and MMD. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 1, 2018 Category: Neurology Authors: Hao Jiang, Juan F. Toscano, Michael Schiraldi, Shlee S. Song, Konrad H. Schlick, Oana M. Dumitrascu, Raymond Liou, Patrick D. Lyden, Jianwei Pan, Renya Zhan, Jeffrey L. Saver, Nestor R. Gonzalez Source Type: research

Ischemic Stroke Transfer Patterns in the Northeast United States
Little is known about how hospitals are connected in the transfer of ischemic stroke (IS) patients. We aimed to describe differences in characteristics of transferred versus nontransferred patients and between transferring and receiving hospitals in the Northeastern United States, and to describe changes over time. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 30, 2018 Category: Neurology Authors: Kori S. Zachrison, Jukka-Pekka Onnela, Adrian Hernandez, Mathew J. Reeves, Carlos A. Camargo, Margueritte Cox, Roland A. Matsouaka, Joshua P. Metlay, Joshua N. Goldstein, Lee H. Schwamm Source Type: research

Development of a Self-Efficacy Questionnaire for Walking in Patients with Mild Ischemic Stroke
This study aimed to develop a self-efficacy questionnaire, which particularly focuses on walking in patients with mild ischemic stroke and transient ischemic attack. Methods:We enrolled patients with acute ischemic stroke and transient ischemic attack who scored 0-2 on the modified Rankin Scale. The process of development of questionnaire on self-efficacy for walking with 7 items (SEW-7) was composed of 3 steps: (1) item generation; (2) item reduction; and (3) testing the final version. The measurement properties were assessed according to the COnsensus-based Standards for the selection of health Measurement INstruments (C...
Source: Journal of Stroke and Cerebrovascular Diseases - October 30, 2018 Category: Neurology Authors: Hiroyuki Kawajiri, Takuji Adachi, Yuji Kono, Sumio Yamada Source Type: research

Hemorrhagic Transformation After Acute Ischemic Stroke in Atrial Fibrillation Patients
We are truly grateful to yours and the reviewers ’ critical comments and thoughtful suggestions. After carefully considering and discussing the suggestions mentioned in the letter, we summarize the following points and hope to communicate with the reviewers to make progressive together. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 29, 2018 Category: Neurology Authors: Wan-Qian Ge, Hui Dang, Cheng-Ye Zhou Tags: Letter to the Editor Source Type: research

Intracerebral Hemorrhage in Multiple Sclerosis: A Retrospective Cohort Study
Background: To identify the vascular risk factors associated with the occurrence of intracerebral hemorrhage (ICH) in Multiple Sclerosis (MS) patients. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 29, 2018 Category: Neurology Authors: Maryam Zulfiqar, Fares Qeadan, Asad Ikram, Mudassir Farooqui, Sarah P. Richardson, Christopher S. Calder, Syed A. Quadri, Puja Mathur, Corey Ford, Santiago O.Gutierrez, Enrique Liera, Harry Snow, Joel N.Gonzalez, Atif Zafar Source Type: research

Is Management of Central Retinal Artery Occlusion the Next Frontier in Cerebrovascular Diseases?
I was interested to read the long review article by Limaye and colleagues entitled “Is management of central retinal artery occlusion the next frontier in cerebrovascular diseases?”1 (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 26, 2018 Category: Neurology Authors: Sohan Singh Hayreh Source Type: research

Health-Related Quality of Life and Fatigue After Transient Ischemic Attack and Minor Stroke
Studies suggest that fatigue and cognitive impairment may be present after transient ischemic attack (TIA) or minor stroke, but little is known about consequences in daily life. The main aim was to explore the presence of fatigue, cognitive impairment, and consequences in daily life after minor stroke-TIA. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 26, 2018 Category: Neurology Authors: Jos é M. Ramírez-Moreno, Pedro Muñoz-Vega, Sandra Bartolomé Alberca, Diego Peral-Pacheco Source Type: research

Hemorrhagic Transformation After Acute Ischemic Stroke in Atrial Fibrillation Patients
We read with interest the study by Ge, Wan-Qian et al.1 One of the results from the study was that the risk of hemorrhagic transformation (HT) was higher in patients with atrial fibrillation (AF). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 26, 2018 Category: Neurology Authors: George K. Vilanilam, Mohammed K. Badi, Bhavya Yarlagadda, Lela Okromelidze Source Type: research

MiR-34b Protects Against Focal Cerebral Ischemia-Reperfusion (I/R) Injury in Rat by Targeting Keap1
Ischemic stroke is one of the leading causes of death and disability globally and has been regarded as a major public health problem. Understanding the mechanism of ischemia/reperfusion (I/R)-induced oxidative stress injury may provide new treatment for ischemic stroke. Kelch-like ECH-associated protein 1 (Keap1)/ NF-E2-related factor 2 (Nrf2)/ antioxidant response elements (ARE) signaling pathway has been considered to be the major cellular defense against oxidative stress. In the present study, our objective is to evaluate the molecular mechanism of miR-34b/Keap1 in modulating focal cerebral I/R induced oxidative injury....
Source: Journal of Stroke and Cerebrovascular Diseases - October 24, 2018 Category: Neurology Authors: Rong Huang, Juan Ma, Bo Niu, Jin Li, Jian Chang, Yanrui Zhang, Peng Liu, Xinping Luan Source Type: research

Isosteviol Sodium Protects Neural Cells Against Hypoxia-Induced Apoptosis Through Inhibiting MAPK and NF- κB Pathways
Stevioside, isolated from the herb Stevia rebaudiana, has been widely used as a food sweetener all over the world. Isosteviol Sodium (STV-Na), an injectable formulation of isosteviol sodium salt, has been proved to possess much greater solubility and bioavailability and exhibit protective effects against cerebral ischemia injury in vivo by inhibiting neuron apoptosis. However, the underlying mechanisms of the neuroprotective effects STV-Na are still not completely known. In the present study, we investigated the effects of STV-Na on neuronal cell death caused by hypoxia in vitro and its underlying mechanisms. (Source: Jour...
Source: Journal of Stroke and Cerebrovascular Diseases - October 24, 2018 Category: Neurology Authors: Kai-Lun Zhong, Min-Yi Lu, Fei Liu, Ying Mei, Xue-Ju Zhang, Hao Zhang, Jie Zan, Xiao-Ou Sun, Wen Tan Source Type: research

The NAG Scale: Noble Predictive Scale for Hematoma Expansion in Intracerebral Hemorrhage
We appreciate Dr. Hegde's interest in our study concerning the outcome of intracerebral hemorrhage (ICH) patients with a NAG (NAG stands for initial of 3 factors, NIHSS, Anticoagulants, and Glucose) score 2. We reviewed their clinical data again and carefully evaluated the same. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 24, 2018 Category: Neurology Authors: Kenichi Sakuta, Teppei Komatsu, Kenichiro Sakai, Yuka Terasawa, Hidetaka Mitsumura, Yasuyuki Iguchi Tags: Letter to the Editor Source Type: research

Predictors of Direct Enteral Tube Placement After Acute Stroke
To determine predictors of direct enteral tube (DET) placement after acute stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 24, 2018 Category: Neurology Authors: Raed A. Joundi, Gustavo Saposnik, Rosemary Martino, Jiming Fang, Moira K. Kapral Source Type: research

Impact of Relative Blood Glucose Changes on Mortality Risk of Patient with Acute Ischemic Stroke and Treated with Mechanical Thrombectomy
This study aimed to use stress hyperglycemia ratio (SHR) to evaluate the influence of pretreatment relative blood glucose changes on mortality risk after MT. Methods: The study retrospectively enrolled 321 acute ischemic stroke patients treated with MT. SHR was calculated as random blood glucose at admission divided by average blood glucose which estimated by glycosylated hemoglobin (HbA1c). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 24, 2018 Category: Neurology Authors: Ling Wang, Zhiming Zhou, Xiguang Tian, Huaiming Wang, Dong Yang, Yonggang Hao, Zhonghua Shi, Min Lin, Zhen Wang, Dequan Zheng, Mingyi Tu, Wenjie Zi, Gelin Xu, Xinfeng Liu, for the ACTUAL investigators Source Type: research

Cerebral Vasoreactivity in Children with Sickle Cell Disease: A Transcranial Doppler Study
I read with great interest the original article by Macedo-Campos et al1 titled “Cerebral Vasoreactivity in Children with Sickle Cell Disease: A Transcranial Doppler Study.” Authors have explored the cerebrovascular reactivity assessed by breath-holding index (BHI) in the children with sickle cell disease (SCD). They have reported the impaired cerebrovascular reactivity in the children with SCD as compared to that of control subjects. However, few potential methodological limitations need to be addressed regarding this study. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 24, 2018 Category: Neurology Authors: Kiran Prakash Tags: Letter to the Editor Source Type: research

Features of Patients Aged 80 Years or Older with Embolic Stroke of Undetermined Source
In this study, we investigated the features of this condition in patients greater than or equal to 80 years of age. Methods: All patients with acute ischemic stroke in our hospital underwent diffusion-weighted imaging, magnetic resonance angiography, T2-weighted imaging, and fluid-attenuated inversion recovery sequence imaging. Embolic stroke of undetermined source was defined as a radiologically confirmed nonlacunar brain infarct on diffusion-weighted imaging without (1) extracranial or intracranial atherosclerosis causing greater than or equal to 50% luminal stenosis in arteries supplying the ischemic area, (2) major-ris...
Source: Journal of Stroke and Cerebrovascular Diseases - October 24, 2018 Category: Neurology Authors: Tomonori Iwata, Kazunari Honma, Hideyuki Hanano, Ayana Kadokura, Eiichiro Nagata, Shunya Takizawa Source Type: research

Is Management of Central Retinal Artery Occlusion the Next Frontier in Cerebrovascular Diseases?
We thank the editors for allowing us to reply to the exhaustive commentary by Professor Sohan Singh Hayerh to our recent review.1 We note that his criticisms of our paper are quite similar to those that he submitted in response to the EAGLE trial.2 The response by Feltgen et al3 has answered the limitations of the points he raises and hence we do not wish to again reiterate the same here. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 24, 2018 Category: Neurology Authors: Kaustubh Limaye, Harold P. Adams Tags: Letter to the Editor Source Type: research

Successful mechanical thrombectomy in stroke with thrombolysis-associated intracerebral hemorrhage —a case report
Intravenous thrombolysis and mechanical thrombectomy are the standard of care for patients with acute ischemic stroke with large vessel occlusion. Intracerebral hemorrhage is a main complication of intravenous thrombolysis, however, no data are available on the efficacy and safety of mechanical thrombectomy in patients with thrombolysis-associated intracerebral hemorrhage. This constellation is expected to become more frequent as increasing numbers of patients are treated under the drip-and-ship paradigm. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 24, 2018 Category: Neurology Authors: Johannes M. Weller, Elke Hattingen, Gabor C. Petzold, Felix J Bode Source Type: research

Corrigendum to “Predicting Motor and Cognitive Improvement Through Machine Learning Algorithm in Human Subject That Underwent a Rehabilitation Treatment in the Early Stage of Stroke” [J Stroke Cerebrovasc Dis 27/11 (2018) 2962-2972]
The authors would like to inform the readers of a needed clarification in this article. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 24, 2018 Category: Neurology Authors: Patrizio Sale, Giorgio Ferriero, Lucio Ciabattoni, Anna Maria Cortese, Giovanni Gentile, Francesco Ferracuti, Luca Romeo, Francesco Piccione, Stefano Masiero Tags: Corrigendum Source Type: research

Prolonged Autonomic Fluctuation Derived from Parasympathetic Hypertonia after Carotid Endarterectomy but not Stenting
Carotid endarterectomy (CEA) is a standard treatment for carotid artery stenosis, but the incidence after periprocedural myocardial infarction (MI) is not negligible. The mechanism for the higher risk of MI following CEA compared with the carotid artery stenting (CAS) is unclear. We hypothesized that it may be explained by different autonomic nervous responses. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 23, 2018 Category: Neurology Authors: Mari Amino, Masataka Nakano, Takashi Komatsu, Reisuke Yoshizawa, Fusanori Kunugita, Ken Kiyono, Norihiko Shinozaki, Kuniaki Ogasawara, Yoshihiro Morino, Koichiro Yoshioka, Yuji Ikari Source Type: research

Recurrent Cerebral Infarction Due to Benign Uterine Myoma
We report a case of recurrent ischemic stroke in a middle-aged woman who had a benign uterine tumor. After excision, there was no recurrence for 2 years. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 23, 2018 Category: Neurology Authors: Eiko Higuchi, Sono Toi, Yuka Shirai, Satoko Mizuno, Hiromi Onizuka, Yoji Nagashima, Kazunori Hashimoto, Kazuo Kitagawa Tags: Case Reports Source Type: research

SIRT1: The Value of Functional Outcome, Stroke-Related Dementia, Anxiety, and Depression in Patients with Acute Ischemic Stroke
Background: The outcome of ischemic stroke depends on multiple factors and their function of each other. Studies have shown that Sirtuin1 (SIRT1) plays a chief role in the key procedure during ischemia/hypoxia by protecting against cellular stress and controlling the metabolic pathways. Aims: To explore the alterations in serum SIRT1 concentrations in acute ischemic stroke (AIS) patients and the relationship between SIRT1 and poststroke dementia, anxiety, and depression. Methods: One hundred and twenty four consecutive patients with clinically diagnosed AIS were recruited to participate in the study. (Source: Journal of St...
Source: Journal of Stroke and Cerebrovascular Diseases - October 23, 2018 Category: Neurology Authors: Xue Liang, Yang Liu, Shiyu Jia, Xiaomin Xu, Meixue Dong, Youdong Wei Source Type: research

Intravenous Thrombolysis Is Safe and Effective for the Cryptogenic Stroke in China: Data From the Thrombolysis Implementation and Monitor of Acute Ischemic Stroke in China (TIMS-China)
The intravenous thrombolysis (IVT) with recombinant tissue plasminogen activator (rt-PA) therapy is safe and efficient during the treatment of acute ischemic stroke. Nonetheless, the different outcomes among various stroke subgroups have limited data with regard to the safety and efficacy of cryptogenic stroke (CS). The present study compared the safety and efficacy when IVT with rt-PA was used for the treatment of CS and the other stroke subtypes. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 23, 2018 Category: Neurology Authors: Yu Fan, Xiaoling Liao, Yuesong Pan, Kehui Dong, Yilong Wang, Yongjun Wang, Thrombolysis Implementation and Monitor of Acute Ischemic Stroke in China (TIMS-China) Investigators Source Type: research