The Effect of Motor and Cognitive Tasks on Gait in People with Stroke
Objective: Gait of people with unilateral stroke is characterized by pronounced asymmetry. The aim of the study was to investigate the effect of cognitive and motor tasks on asymmetry of gait in people with stroke. Materials and Methods: Nine individuals with stroke walked over the GAITRite walkway while performing motor (holding a cup with water) or cognitive (reciting the alphabet) tasks or walked with no additional task. Gait velocity, cadence, and symmetry indexes for the stance phase, swing phase, and single support phase of a gait cycle were calculated. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 19, 2019 Category: Neurology Authors: Etem Curuk, Nikita Goyal, Alexander S. Aruin Source Type: research

Variability and Delay in Telestroke Physician Alert among Spokes in a Telestroke Network: A Need for Metric Benchmarks
We describe variation in time to alert a telestroke physician of suspected acute ischemic stroke patients potentially eligible for acute stroke therapies among community hospitals in our telestroke network, and explore demographic and spoke-related characteristics associated with delays. Methods: From our telestroke registry, we identified suspected acute ischemic stroke patients who arrived within 6 hours of symptom onset and underwent video consultation at 1 of 17 community hospitals in our hub-and-spoke network. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 19, 2019 Category: Neurology Authors: Amanda L Jagolino-Cole, Shima Bozorgui, Christy M Ankrom, Farhaan Vahidy, Arvind B Bambhroliya, Jaskaren Randhawa, Alyssa D Trevino, TC Cossey, Sean I Savitz, Tzu-Ching Wu Source Type: research

Nephrotic Syndrome is Associated with Increased Risk of Ischemic Stroke
Background: To determine if the nephrotic syndrome (NS) is an independent risk factor of ischemic stroke. Methods: This is a retrospective nationwide cohort study through an analysis of the National Health Insurance Research Database in Taiwan. To evaluate the risk of stroke, the corresponding controls were selected at a 4:1 ratio in the number of subjects, and they were matched with the study group in age, gender, Charlson comorbidity index (CCI), and index date. Results: From a total of 16,245 surveyed subjects, ischemic stroke occurred in 1235 (7.6%) and hemorrhagic stroke in 129 (.74%) of them. (Source: Journal of Stro...
Source: Journal of Stroke and Cerebrovascular Diseases - August 16, 2019 Category: Neurology Authors: Jin-An Huang, Ching-Heng Lin, Yao-Tien Chang, Cheng-Ting Lee, Ming-Ju Wu Source Type: research

Intracardiac Thrombus Following Rivaroxaban Treatment in a Patient with Atrial Fibrillation Associated with Rheumatic Heart Disease
We report a case of atrial fibrillation with rheumatic heart disease (RHD) who had intracardiac thrombus and cardiogenic cerebral embolism with rivaroxaban therapy. Intracardiac thrombus disappeared after switching from rivaroxaban to warfarin. Patients of RHD have the possibility of gradual progression of valvular disease even if they are old, so we need to distinguish nonvalvular atrial fibrillation from RHD before starting direct oral anticoagulants. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 16, 2019 Category: Neurology Authors: Hiroaki Ohara, Shiro Yamamoto, Keiko Nagano, Kazuo Hashikawa Tags: Case Report Source Type: research

Usefulness of Oral Xa Inhibitor for Management of Ischemic Stroke Associated with Thrombosis in the Pulmonary Vein Stump after Lung Resection
We describe serial 3 cases of brain infarctions associated with thrombosis in the PV stumps, which were successfully treated with the oral Xa inhibitor rivaroxaban. Methods and Results: We retrospectively reviewed medical records of 3 patients. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 15, 2019 Category: Neurology Authors: Takeo Amemiya, Tadahisa Shono, Keitaro Yamagami, Soh Takagishi, Hiroki Toma, Tomonari Kobarai, Toru Eguchi, Ichio Hirota Source Type: research

Cerebral Venous Sinus Thrombosis Score and its Correlation with Clinical and MRI Findings
Background: It is plausible that extent of cerebral venous sinus thrombosis (CVST) may determine clinical severity, magnetic resonance imaging (MRI) lesion, and outcome, therefore this study was undertaken. Methods: A total of 160 CVST patients were included and their clinical details, risk factors, Glasgow Coma Scale score, and parenchymal lesion on MRI were noted. The extent of venous sinus thrombosis on magnetic resonance venography was assessed by using CVST score which was computed giving 1 point for each thrombosed sinus and 3 points to superior sagittal sinus (SSS). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 15, 2019 Category: Neurology Authors: Jayantee Kalita, Varun K. Singh, Neeraj Jain, Usha K. Misra, Sunil Kumar Source Type: research

Masthead
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 14, 2019 Category: Neurology Source Type: research

Editorial Board
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 14, 2019 Category: Neurology Source Type: research

Table of Contents
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 14, 2019 Category: Neurology Source Type: research

Rapid Disappearance of Intraventricular Mobile Structures with Steroids in Eosinophilic Granulomatosis with Polyangiitis
Endomyocarditis in Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare complication, commonly involving an apical mass compatible with a thrombus. However, no previous report has discussed mobile structures detected by echocardiography in a patient with EGPA. A 53-year-old man with asthma presented with low-grade fever, consciousness disturbance, and vomiting. Magnetic resonance imaging showed multiple acute infarctions in the bilateral cerebrum and cerebellum. Remarkable eosinophilia was observed, and transthoracic echocardiography showed multiple mobile structures originating from the left ventricular septum. ...
Source: Journal of Stroke and Cerebrovascular Diseases - August 14, 2019 Category: Neurology Authors: Kenichi Sakuta, Shinji Miyagawa, Kenichiro Suzuki, Hiroshi Yaguchi Tags: Case Report Source Type: research

Cerebral Blood Flow Response During Bolus Normal Saline Infusion After Ischemic Stroke
Goals: We quantified cerebral blood flow response to a 500 cc bolus of 0.9%% normal saline (NS) within 96 hours of acute ischemic stroke (AIS) using diffuse correlation spectroscopy (DCS). Materials and Methods: Subjects with AIS in the anterior, middle, or posterior cerebral artery territory were enrolled within 96 hours of symptom onset. DCS measured relative cerebral blood flow (rCBF) in the bilateral frontal lobes for 15 minutes at rest (baseline), during a 30-minute infusion of 500 cc NS (bolus), and for 15 minutes after completion (post-bolus). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 13, 2019 Category: Neurology Authors: Michael T. Mullen, Ashwin B. Parthasarathy, Ali Zandieh, Wesley B. Baker, Rickson C. Mesquita, Caitlin Loomis, Jose Torres, Wensheng Guo, Christopher G. Favilla, Steven R. Mess é, Arjun G. Yodh, John A. Detre, Scott E. Kasner Source Type: research

Cardiac Arrhythmias and Acute Cerebrovascular Events: A Case of QT Prolongation and Torsades de Pointes Early After Right Insular Stroke
Stroke involving some areas of the cerebral hemisphere, such as insula, amygdala, and lateral hypothalamus, may cause changes in autonomic control of cardiac function. A 58-year-old woman presented to the emergency department for acute onset of left facial-brachial-crural hemiparesis and dysarthria. A brain CT scan showed subacute ischemic lesion with hemorrhagic infarction in right insular-rolandic cortex. Over the next few days ECG showed severe bradycardia with elongation of QTc, significative pauses (5 seconds), runs of nonsustained ventricular tachycardia and torsades de pointes. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 12, 2019 Category: Neurology Authors: Ilaria Jane Romano, Antonio Lippolis, Margherita D'Anna, Francesco Gentile Tags: Case Report Source Type: research

Urban Versus Rural Egypt: Stroke Risk Factors and Clinical Profile: Cross-Sectional Observational Study
Background: Egypt is a densely populated country with living habits and health care services that differ from urban to rural regions. We aimed to study how characteristics of stroke vary among these regions. Methods: This is a cross-sectional observational study of ischemic stroke, thus hemorrhagic and venous strokes were excluded. A total of 1475 ischemic stroke patients were recruited for analysis from a tertiary hospital in Cairo representing urban area and from a secondary care hospital in Suhag representing rural region. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 12, 2019 Category: Neurology Authors: Nevine M. El Nahas, Hossam M. Shokri, Tamer M. Roushdy, Hany M. Aref, Salma M. Hamed, Ali S. Shalash, Mohamed I. Abdelrahem, Noha L. Dawood, Eman M. Abushady, Shady S. Georgy, Amr S. Zaki, Rady Y. Bedros Source Type: research

Medical Mobile Applications for Stroke Survivors and Caregivers
Recent studies estimate nearly half of the US population can access mobile medical applications (apps) on their smartphones. The are no systematic data available on apps focused on stroke survivors/caregivers. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 12, 2019 Category: Neurology Authors: Pirouz Piran, Jinu Thomas, Saroj Kunnakkat, Abhishek Pandey, Nadege Gilles, Sarah Weingast, Dee Burton, Clotilde Balucani, Steven R. Levine, The Mobile Applications for Stroke (MAPPS) Investigators Source Type: research

Temporal Trends in Clinical Characteristics and Door-to-Needle Time in Patients Receiving Intravenous Tissue Plasminogen Activator: A Retrospective Study of 4 Hospitals in Japan
Background: Intravenous recombinant tissue plasminogen activator (rt-PA) has become a common treatment for acute ischemic stroke and has highly time-dependent benefits. We aimed to clarify temporal trends regarding the frequency and characteristics of patients receiving rt-PA and explore factors associated with door-to-needle time (DNT) in Japanese emergency hospitals. Methods: Consecutive patients who received intravenous rt-PA for acute ischemic stroke from October 2005 to December 2015 were retrospectively registered from 4 hospitals. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 10, 2019 Category: Neurology Authors: Koji Tanaka, Shoji Matsumoto, Takeshi Yamada, Sukehisa Nagano, Kei-ichiro Takase, Taketo Hatano, Ryo Yamasaki, Jun-ichi Kira Source Type: research

Development and Validation of an Exercise Programme for Recovery Balance Impairments in Poststroke Patients
Background: Deterioration of balance is one of the most common and disabling physical-motor deficits in patients after a stroke that have a negative impact on quality of life and increase the risk of falls. Previous studies have evaluated the effectiveness of the exercises on specific aspects of balance. However, there is no structured exercise program divided by levels for balance impairment in poststroke patients. Methods: Delphi method was used to design the exercise programme, and then a pilot study was performed. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 10, 2019 Category: Neurology Authors: Almudena Medina-Rinc ón, Caritat Bagur-Calafat, Laura M. Pérez, Ana M. Barrios-Franquesa, Montserrat Girabent-Farrés Source Type: research

Acute Ischemic Stroke with Vessel Occlusion —Prevalence and Thrombectomy Eligibility at a Comprehensive Stroke Center
Introduction: Endovascular thrombectomy (ET) for acute ischemic stroke (AIS) caused by large vessel occlusion (LVO) can prevent severe disability and mortality. There is currently limited data on the epidemiology of LVO strokes and ET eligibility. We aim to determine the incidence of intracranial vessel occlusion (IVO) strokes eligible for ET per 2018 American Heart Association (AHA) guidelines and characteristics of an AHA ineligible population at a comprehensive stroke center (CSC). Methods: Retrospective chart review of all consecutive AISs at a CSC between November 2014 and February 2017. (Source: Journal of Stroke and...
Source: Journal of Stroke and Cerebrovascular Diseases - August 10, 2019 Category: Neurology Authors: Shashvat M. Desai, Matthew Starr, Bradley J. Molyneaux, Marcelo Rocha, Tudor G. Jovin, Ashutosh P. Jadhav Source Type: research

Dural Sinus Thrombosis with Nonsymptomatic Persistent Falcine Sinus: A Case Report
A 24-year-old woman was admitted to our hospital after convulsive status epilepticus. A cerebral magnetic resonance venography revealed a persistent fetal falcine sinus. Additionally, the posterior third of the superior sagittal sinus was hypoplastic and the abnormal deep venous drainage was accompanied. These abnormalities had already been detected by magnetic resonance imaging several years ago. In the present scan, we discovered a sinus thrombosis in the hypoplastic superior sagittal sinus. In the cerebral angiography, we observed delayed venous return in the left parieto-occipital lobe and hypothesized that cerebral ve...
Source: Journal of Stroke and Cerebrovascular Diseases - August 9, 2019 Category: Neurology Authors: Ayako Shioya, Ryota Mashiko, Masanari Shiigai, Yasunobu Nakai, Nobuyuki Takahashi, Hiroyuki Kobayashi, Toshiyuki Irie, Akira Tamaoka Tags: Case Report Source Type: research

Fever Burden in Patients With Subarachnoid Hemorrhage and the Increased Use of Antibiotics
Background: Fever occurs in the majority of subarachnoid hemorrhage (SAH) patients. Nearly 50% of SAH patients have noninfectious fevers. Data are lacking describing the effects of fever burden in the SAH patient population. Methods: This was a single-center, retrospective observational cohort study in patients more or equal to 18 years of age with a diagnosis of nontraumatic SAH admitted to an ICU between January 1, 2010 and September 1, 2015. Exclusion criteria were SAH secondary to trauma or admission for more than 48 hours. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 9, 2019 Category: Neurology Authors: Carolyn A Magee, Melissa L. Thompson Bastin, Katelyn Graves, Donna Burgess, Melissa Nestor, John R. Lamm, Aaron M. Cook Source Type: research

Intraoperative Aneurysm Rupture during Resection for Presumed Metastasis
A 54-year-old male with metastatic melanoma, including a presumed brain metastasis underwent elective surgery when there was sudden onset of extensive bleeding upon resection. An emergent cerebral angiogram revealed a fusiform left posterior cerebral artery aneurysm. Malignant melanoma commonly metastasizes to the brain and has shown to assume a wide variety of appearances with involvement of almost any intracranial structures. The unexpected intraoperative finding required immediate action and strategic rethinking. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 9, 2019 Category: Neurology Authors: Anna L. K ühn, Katyucia de Macedo Rodrigues, Ajit S. Puri Tags: Case Report Source Type: research

Migraine History: A Predictor of Negative Diffusion-Weighted Imaging in IV-tPA-Treated Stroke Mimics
Background: Migraine, seizures, and psychiatric disorders are frequently reported as “stroke mimics” in patients with negative diffusion-weighted imaging (DWI) after IV-tPA. We sought to determine predictors of negative DWI in suspected stroke patients treated with IV-tPA. Method: A retrospective case-control study encompassing all acute stroke patients treated with IV-tPA (at o ur hospital or “dripped and shipped”) from January 2013 to December 2014 was con- ducted. A total of 275 patients were identified with 47 negative DWI cases and 228 positive DWI controls. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 8, 2019 Category: Neurology Authors: Jussie Lima, Tapan Mehta, Neil Datta, Ekaterina Bakradze, Ilene Staff, Dawn Beland, Amre Nouh Source Type: research

Educating Stroke/TIA Patients about Obstructive Sleep Apnea after Stroke: A Randomized Feasibility Study
This study aimed to develop and conduct a preliminary assessment of educational materials for poststroke/TIA OSA. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 7, 2019 Category: Neurology Authors: Laavanya Dharmakulaseelan, Nardin Kirolos, Maneesha Kamra, Armi Armesto-Heys, Cathy Bouthillier, Sharron Runions, Elizabeth Linkewich, Brian J. Murray, Mark I., Boulos Source Type: research

Clematichinenoside Facilitates Recovery of Neurological and Motor Function in Rats after Cerebral Ischemic Injury through Inhibiting Notch/NF- κB Pathway
Purpose: The present study was to observe the therapeutic efficiency of Clematichinenoside (AR) on cerebral ischemic injury in rats, especially on neurological and motor function recovery and to explore the underlying mechanism. Methods: Following middle cerebral artery occlusion/reperfusion (MCAO/R) surgery, rats were treated orally with 32, 16, and 8 mg/kg AR respectively for 14 days during which cerebral injury was evaluated and proinflammatory factors tumor necrosis factor- α and interleukin-6 as well as neurotrophic factors brain-derived neurotrophic factor and Neurotrophin-3 levels were determined with ELISA ki...
Source: Journal of Stroke and Cerebrovascular Diseases - August 6, 2019 Category: Neurology Authors: Dan Xu, Nian Xia, Kai Hou, Fengyang Li, Shijie Chen, Yahui Hu, Weirong Fang, Yunman Li Source Type: research

The Effect of Continuous Theta-Burst Transcranial Magnetic Stimulation Combined with Prism Adaptation on the Neglect Recovery in Stroke Patients
This study was designed to investigate the effect of prism adaptation (PA) combined with continuous theta-burst transcranial magnetic stimulation (cTBS) on the neglect recovery of stroke patients with unilateral neglect. Methods: A total of 14 stroke patients with unilateral neglect were randomly assigned to 2 groups including an intervention group undergone PA combined with cTBS over the left intact parietal cortex and a control group. PA combined with sham cTBS was perfomed for 2 weeks in 10 daily sessions. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 6, 2019 Category: Neurology Authors: Shole Vatanparasti, Anoshirvan Kazemnejad, Ali Yoonessi, Shahram Oveisgharan Source Type: research

Imaging Classification of Internal Carotid Artery Hypoplasia Based on Distal Ophthalmic Segment Occlusion
Background: Internal carotid artery (ICA) hypoplasia (ICAH) is rare. The classification of ICAH is largely unclear. The aim of the study is to propose a new imaging classification for ICAH based on the occlusion of the distal ophthalmic segment and discuss the clinical and radiological differences between the different types. Materials and Methods: This was a retrospective study of patients with congenital ICAH diagnosed at the Department of Neurology of the China-Japan Friendship Hospital between June 2011 and June 2016. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 6, 2019 Category: Neurology Authors: Zhiyong Zhang, Zhiqin Liu, Zunjing Liu Source Type: research

Pre-Existing Cerebral Small Vessel Disease Limits Early Recovery in Patients with Acute Lacunar Infarct
Background and Purpose: To assess whether neuroimaging markers of chronic cerebral small vessel disease (cSVDm) influence early recovery after acute ischemic stroke (AIS). Methods: Retrospective analysis of patients diagnosed with AIS and included in the Spanish Neurological Society Stroke Database. Inclusion criteria: (1) Brain MRI performed after acute stroke and (2) Premorbid modified Rankin scale (mRS)  = 0. Exclusion criteria: (1) Uncommon stroke etiologies, (2) AIS not confirmed on neuroimaging, or (3) Old territorial infarcts on neuroimaging. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 5, 2019 Category: Neurology Authors: Manuel G ómez-Choco, Juan José Mengual, Jon Rodríguez-Antigüedad, Martí Paré-Curell, Francisco Purroy, Ernest Palomeras, Blanca Fuentes, Xavier Ustrell, José Tembl, Manuel Rodríguez-Yañez, Mar Castellanos, Joan Martí-Fabregas, Joaquín Serena Source Type: research

Older Age Is Not Associated with Worse Outcomes Following Decompressive Hemicraniectomy for Spontaneous Intracerebral Hemorrhage
Background: Decompressive hemicraniectomy (DHC) is commonly offered after large spontaneous intracerebral hemorrhage (ICH) as a life-saving measure. Based on limited available evidence, surgery is sometimes avoided in the elderly. The association between age and outcomes following DHC in spontaneous ICH remains largely understudied. Objective: The goal of this study is to investigate the influence of older age on outcomes of patients who undergo DHC for spontaneous ICH. Methods: In this retrospective cohort study, inpatient data were obtained from the United States Nationwide Inpatient Sample from 2000 to 2011. (Source: Jo...
Source: Journal of Stroke and Cerebrovascular Diseases - August 5, 2019 Category: Neurology Authors: Roy A. Poblete, Ling Zheng, Marcela Arenas, Alejandro Vazquez, Derek Yu, Benjamin A. Emanuel, May A. Kim-Tenser, Nerses Sanossian, William Mack Source Type: research

Prognostic Value of Clot Burden Score in Acute Ischemic Stroke after Reperfusion Therapies: A Systematic Review and Meta-Analysis
Background and Aim: Clot burden score (CBS) was designed to weight the thrombus status in cerebral anterior circulation. We performed a systematic review and meta-analysis to investigate the prognostic value of CBS in acute ischemic stroke (AIS) patients undergoing reperfusion therapies. Methods: We searched relevant databases for eligible articles reporting CBS in AIS patients. The effect sizes of good functional outcome, recanalization, or hemorrhagic transformation (HT) were pooled with random-/fixed-effect models. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 3, 2019 Category: Neurology Authors: Guoming Li, Guangliang Wu, Zhengjie Qin, Huiping Li, Xiao Cheng, Yefeng Cai Source Type: research

Twendee X Ameliorates Phosphorylated Tau, α-Synuclein and Neurovascular Dysfunction in Alzheimer's Disease Transgenic Mice With Chronic Cerebral Hypoperfusion
Background: The pathological impact of chronic cerebral hypoperfusion (CCH) on Alzheimer's disease (AD) is still poorly understood. In the present study, we investigated the role of CCH on an AD mouse model in phosphorylated tau and α-synuclein pathology, neurovascular unit, cerebrovascular remodeling, and neurovascular trophic coupling. Moreover, examined protective effect of a new antioxidant Twendee X (TwX). Methods: APP23 mice were implanted to bilateral common carotid arteries stenosis with ameroid constrictors to gradual ly decrease the cerebral blood flow. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 3, 2019 Category: Neurology Authors: Xia Liu, Toru Yamashita, Jingwei Shang, Xiaowen Shi, Ryuta Morihara, Yong Huang, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Koji Abe Source Type: research

A Case of Juvenile Stroke due to Carotid Artery Dissection from an Elongated Styloid Process —Revisiting Conservative Management
Carotid artery dissection is a significant etiology of juvenile stroke. Blunt trauma from an elongated styloid process can rarely cause carotid artery dissection, which is one of well-known clinical presentations of Eagle's syndrome as known as stylocarotid syndrome. Growing number of publications contributed improved awareness and diagnostic modalities for this clinical entity, thus the carotid artery dissection from an elongated styloid process is often diagnosed appropriately. The management of carotid artery dissection in stylocarotid syndrome tends to be nonconservative (ie, removal of the process or carotid stenting)...
Source: Journal of Stroke and Cerebrovascular Diseases - August 2, 2019 Category: Neurology Authors: Takafumi Shindo, Masaki Ito, Juntaro Matsumoto, Koichi Miki, Fumiaki Fujihara, Shunsuke Terasaka, Toyohiko Isu, Masanori Isobe Tags: Case Report Source Type: research

Retraction notice to “Beneficial Effect of Etidronate Therapy in Chronically Hospitalized, Disabled Patients with Stroke” [Journal of Stroke and Cerebrovascular Diseases, Volume 19, Issue 3, May 2010, Pages 198-203]
Available online: 29 April 2010 (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 31, 2019 Category: Neurology Authors: Yoshihiro Sato, Jun Iwamoto, Yoshiaki Honda Tags: Retraction notice Source Type: research

Masthead
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 31, 2019 Category: Neurology Source Type: research

Editorial Board
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 31, 2019 Category: Neurology Source Type: research

Table of Contents
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 31, 2019 Category: Neurology Source Type: research

Intracerebral Hemorrhage in a Young Urban Population: Etiologies and Outcomes in Patients 50 and Younger
Goal: There is limited research on intracerebral hemorrhage in young urban populations. There is reduced access to healthcare and a high prevalence of multiple comorbidities in this vulnerable population. We studied the etiologies and outcomes of spontaneous intracerebral hemorrhage in an urban North Philadelphia cohort aged 50 years old and younger. Materials and methods: A retrospective chart review of subjects 50 years old and younger who presented with spontaneous intracerebral hemorrhage at Temple University Hospital was conducted. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 31, 2019 Category: Neurology Authors: Aron Gedansky, Paul Jarvis, Daohai Yu, Xiaoning Lu, Terry Heiman-Patterson, Guillermo Linares Source Type: research

Aspiration Catheter Reach to Thrombus (ART) Sign in Combined Technique for Mechanical Thrombectomy: Impact for First-Pass Complete Reperfusion
Objective: The important factor for successful first-pass complete reperfusion (FPR) after combined techniques for mechanical thrombectomy (MT) is unclear. We consider that for successful FPR, the aspiration catheter (AC) should reach to and hold the thrombus before the device is pulled out. Therefore, we defined an ART (AC reached thrombus) sign characterized by the cessation of reverse blood flow in aspiration pump and deformation of stent retriever (SR) at the tip of AC. The purpose of this study was to identify the impact of the ART sign on the outcomes of the combined techniques. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 31, 2019 Category: Neurology Authors: Taichiro Mizokami, Takeshi Uwatoko, Kenichi Matsumoto, Yuichiro Ooya, Go Hashimoto, Motofumi Koguchi, Hideki Iwashita, Kiku Uwatoko, Hiroshi Takashima, Hiroshi Sugimori, Syuji Sakata Source Type: research

CT-based Higher Thrombus Density is associated with Secondary Embolism during Mechanical Thrombectomy: A Preliminary Observation
This study addresses a potential relationship between thrombus density on preinterventional computed tomography (CT) and the occurrence of SE. Methods: We reviewed anterior circulation AIS patients who underwent MT from July 2015 to January 2019 in our center. Thrombus density was measured in Hounsfield Units (HU) on 1-mm and 5-mm preinterventional nonenhanced CT (NECT). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 31, 2019 Category: Neurology Authors: Gengfan Ye, Ruoyao Cao, Jun Lu, Peng Qi, Juan Chen, Daming Wang Source Type: research

Re Alarming Results for Carotid Artery Stenting in Patients with Contralateral Carotid Artery Occlusion
Thank you for the interest in our data. Although the 3-year stroke, Myocardial Infarction (MI), or death rates in the entire cohort of 49 patients was relatively high (18.4%), the majority of patients less than 75 years old had a stroke rate of 5% and a stroke-MI-death rate of 10.5% over 3 years. We agree that these data are not as good as carotid endarterectomy (CEA), but we stand by our conclusion that carotid artery stenting (CAS) in patients with contralateral carotid artery occlusion (CCO) is a safe and effective therapy. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 30, 2019 Category: Neurology Authors: Jianming Guo, Alan Dardik, Yongquan Gu Tags: Letter to the Editor Source Type: research

Resumption of Direct Oral Anticoagulants in Patients with Acute Spontaneous Intracerebral Hemorrhage
We examined the timing of DOAC resumption and factors that influence decision-making in DOAC resumption. Methods: We retrospectively analyzed 43 patients with ICH who were treated with DOAC for nonvalvular atrial fibrillation before ICH onset. All patients were divided into 2 groups (resumption of DOAC and no resumption of DOAC) during hospitalization. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 30, 2019 Category: Neurology Authors: Yuji Kato, Takeshi Hayashi, Kaima Suzuki, Hajime Maruyama, Yuichiro Kikkawa, Hiroki Kurita, Masaki Takao Source Type: research

Cognitive Rehabilitation Improves Ischemic Stroke-Induced Cognitive Impairment: Role of Growth Factors
Cognitive dysfunction is the most common nonphysical impairment in the stroke survivors. This impairment has a negative impact on patients ’ quality of life affects their daily living activities. Both pharmacological and nonpharmacological interventions are employed to improve cognitive impairment. Recently, nonpharmacological interventions have attracted great attention. Cognitive rehabilitation is considered as a therapeutic strate gy to improve and maintain cognitive skills in patients with stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 30, 2019 Category: Neurology Authors: Fatemeh Farokhi-Sisakht, Mehdi Farhoudi, Saeed Sadigh-Eteghad, Javad Mahmoudi, Gisou Mohaddes Tags: Review Article Source Type: research

Safety and Efficacy of Repeated Thrombolysis with Alteplase in Early Recurrent Ischemic Stroke: A Systematic Review
Background and Aim: The current American Heart Association guidelines for the management of acute ischemic stroke advise against the use of intravenous (IV) alteplase in patients with recurrent stroke occurring within 90 days of their index event. Following these guidelines strictly, patients having early recurrent ischemic stroke would be unable to avail of this reperfusion strategy that has been proven to confer superior clinical outcomes. While some registry-based studies have demonstrated the safety of IV alteplase in this subgroup of patients, data on the repeated use of the drug are lacking. (Source: Journal of Strok...
Source: Journal of Stroke and Cerebrovascular Diseases - July 29, 2019 Category: Neurology Authors: Robert Joseph Cruz Sarmiento, Jose Danilo Bengzon Diestro, Adrian Isidoro Espiritu, Maria Cristina Zarsadias San Jose Source Type: research

Proximal Common Carotid Artery Stenosis Induced by Repetitive Mechanical Compression: A Case Report
Objectives: Arterial branches and curvatures, such as the common carotid artery (CCA) origin and carotid bifurcation, are usual sites of atherosclerosis, which leads to carotid artery stenosis. Atherosclerosis may occur due to repetitive compression. Stenosis localized to the proximal segment away from the CCA origin and bifurcation is rare. Here, we describe the case of a patient with right proximal CCA stenosis induced by repetitive compression. Methods: We studied an acute stroke patient who worked for a long time as a geographical surveyor carrying a tripod on his right shoulder. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 29, 2019 Category: Neurology Authors: Takuya Saito, Ryo Itabashi, Yuya Kobayashi, Yuichi Kawabata, Yukako Yazawa Tags: Case Report Source Type: research

Discovery of a novel mutation in the REN gene in patient with chronic progressive kidney disease of unknown etiology presenting with acute spontaneous carotid artery dissection
We report on a 36-year-old male with the right internal carotid artery dissection and a novel genetic variant in the REN gene. Our report offers evidence that mutations in the REN gene could have pathogenic role in arterial dissection. The subject gave written informed consent for the publication of this case report. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 29, 2019 Category: Neurology Authors: Timotej Petrijan, Marija Menih Tags: Case Report Source Type: research

Toward Improving Poststroke Aphasia: A Pilot Study on the Growing Use of Telerehabilitation for the Continuity of Care
Background: Aphasia is a quite common and very disabling symptom following stroke, negatively affecting patient's quality of life. Aim of the study is to evaluate the effectiveness of a rehabilitation training for aphasia that employ a touch-screen tablet using a virtual reality rehabilitation system (VRRS-Tablet). Material and Methods: Thirty patients with aphasia due to ischemic or hemorrhagic stroke were randomized into either the control or the experimental group and assessed by means of a specific neuropsychological evaluation. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 29, 2019 Category: Neurology Authors: Giuseppa Maresca, Maria Grazia Maggio, Desiree Latella, Antonino Cannav ò, Maria Cristina De Cola, Simona Portaro, Maria Chiara Stagnitti, Giuseppe Silvestri, Michele Torrisi, Alessia Bramanti, De Luca Rosaria, Rocco Salvatore Calabrò Source Type: research

Initial National Institute of Health Stroke Scale to Early Predict the Improvement of Swallowing in Patients with Acute Ischemic Stroke
Objectives: To study the applicability of National Institutes of Health Stroke Scale (NIHSS) in early predicting the prognosis of poststroke dysphagia in an acute ward. Methods: This is an observational retrospective cohort study including adult patients with ischemic stroke. Patients with various factors affecting swallowing were excluded to obtain a representative sample of 165 patients. The main outcome measure was the improvements of oral intake function. Results: The scores of facial palsy (NIHSS item 4) (odds ratio [OR]: 0.484, 95% confidence interval [CI]: 0.279-0.838, P = .0096] and language/aphasia (NIHSS item 9) ...
Source: Journal of Stroke and Cerebrovascular Diseases - July 27, 2019 Category: Neurology Authors: Wen-Chih Lin, Chih-Yuan Huang, Lin-Fu Lee, Yun-Wen Chen, Chung-Han Ho, Yuan-Ting Sun Source Type: research

Correlation Between Cerebral Microbleeds and Vulnerable Plaque in Patients with Severe Carotid Artery Stenosis; Comparative Magnetic Resonance Imaging Study
This study was aimed to evaluate the correlation between microbleeds and carotid plaque characteristics. Materials and Methods: This study enrolled 85 patients who underwent surgical/endovascular treatments for carotid artery stenosis between January 2009 and July 2016. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 27, 2019 Category: Neurology Authors: Satoshi Hori, Emiko Hori, Takashi Shibata, Kimiko Umemura, Soushi Okamoto, Michiya Kubo, Yukio Horie, Satoshi Kuroda Source Type: research

Factors Associated With In-Hospital Mortality in Very Elderly Patients With Ischemic Stroke: A Cohort Study
The highest mortality rates associated with ischemic stroke occur in patients of advanced age. However, studies of factors that establish the increase in hospital mortality are scanty in this population. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 25, 2019 Category: Neurology Authors: Am érico Danúzio Pereira de Oliveira, Luciana Patrizia Alves de Andrade-Valença, Marcelo Moraes Valença Source Type: research

Pure Cortical Stroke Causing Hemichorea-Hemiballismus
We report a case of a 72-year-old man with vascular risk factors who presented with acute onset right-sided hemichorea-hemiballism. Metabolic-, infectious-, and toxic-related conditions were ruled out, his EEG was without epileptiform changes. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 25, 2019 Category: Neurology Authors: Sara Strauss, Daniel Rafie, Anitha Nimma, Raquel Romero, Philip A. Hanna Tags: Case Report Source Type: research

Prevalence of Nonstenotic Carotid Plaque in Stroke Due to Atrial Fibrillation Compared to Embolic Stroke of Undetermined Source
Background: Embolic stroke of undetermined source (ESUS) accounts for about 20% of strokes. Nonstenotic cervical arterial plaque may be a mechanism of stroke in a subset of these patients. Methods: A cohort of consecutive patients with ischemic stroke was retrospectively identified from a stroke registry. Patients with unilateral anterior circulation embolic stroke due to atrial fibrillation (AF) or consistent with ESUS who underwent computed tomographic neck angiography were included. The prespecified primary outcome was a comparison of the prevalence of carotid plaque greater than or equal to 3 mm thickness ipsilateral v...
Source: Journal of Stroke and Cerebrovascular Diseases - July 25, 2019 Category: Neurology Authors: James E. Siegler, Jesse M. Thon, John H. Woo, David Do, Steven R. Mess é, Brett Cucchiara Source Type: research

Asian Study of Cerebral Venous Thrombosis
The objective of the present study is to identify risk factors, presentation, and outcome of CVT in Asian patients. Methods: Asian CVT registry is a prospective multinational observational study that included patients (aged> 16 years) with symptomatic CVT. Results: Eight hundred and twelve patients (59% women) from 20 centers in 9 Asian countries were included. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 24, 2019 Category: Neurology Authors: Mohammad Wasay, Subash Kaul, Bindu Menon, Alper I. Dai, Mohammad Saadatnia, Abdul Malik, Ahmed Khalifa, Afshin Borhani-Haghigi, Manmohan Mehndiratta, Maria Khan, Nimalendu Bikash Bhowmik, Safia Awan Source Type: research