Bilateral large vessel occlusion causing massive ischemic stroke in a covid-19 patient
The case of a 70-year-old male presenting an ischemic stroke related to COVID-19 infection is described. He was initially admitted to the hospital with respiratory insufficiency syndrome secondary to pneumonia caused by SARS Co2. In the next days, he developed rapid neurological deterioration characterized by drowsiness which progressed to deep coma. D-dimer was elevated. Brain CT scan showed bilateral massive ischemic stroke located in the anterior circulation, CT angiogram showed occlusion in the left internal carotid artery and the right middle cerebral artery. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 7, 2021 Category: Neurology Authors: Luis A. Robles Tags: Case Report Source Type: research

The Association between Cerebral Small Vessel Disease and the Gut Microbiome: A Cross-Sectional Analysis
Cerebral small vessel disease (SVD) has been a research focus as a risk factor for both stroke and dementia.1 Cerebral SVD is characterised by brain magnetic resonance imaging (MRI) abnormalities, as silent lacunar infarcts (SLIs), white matter hyperintensities (WMHs), cerebral microbleeds (CMBs), and enlarged periventricular spaces (EPVSs).1 These findings are frequently encountered in patients with vascular risk factors, and are also common in patients with early stages of cognitive impairment. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 7, 2021 Category: Neurology Authors: Naoki Saji, Kenta Murotani, Takayoshi Hisada, Tsuyoshi Tsuduki, Taiki Sugimoto, Ai Kimura, Shumpei Niida, Kenji Toba, Takashi Sakurai Source Type: research

Adoption of the Transradial Approach for Neurointerventions: A National Survey of Current Practitioners
The transradial approach (TRA) has been demonstrated to reduce mortality, morbidity, access-site complications, hospital cost, and hospital length of stay when compared to the transfemoral approach (TFA) in multiple cardiac trials.1-6 The approach is technically feasible for both diagnostic7 and therapeutic8,9 neurointerventions. Patients strongly prefer procedures done via TRA,10,11 likely due to increased postprocedural comfort. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 6, 2021 Category: Neurology Authors: Somnath Das, Sunidhi Ramesh, Lohit Velagapudi, Ahmad Sweid, Reid Gooch, Stavropoula Tjoumakaris, Robert H. Rosenwasser, Pascal Jabbour Source Type: research

Factor XII Concentrations and Risk of Intracerebral Haemorrhage. A Prospective Case-Referent Study
Intracerebral haemorrhage (ICH) accounts for about 15% of all stroke in Sweden and is associated with high rates of death and disability.1,2 Biomarkers can be used in predicting disease risk as well as for disease diagnosis and prognosis estimation.3 A range of biomarkers have been studied in relationship to risk of ICH.4-7 (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 5, 2021 Category: Neurology Authors: Kristina Johansson, Lars Johansson, Torbj örn K. Nilsson, Marcus M. Lind Source Type: research

Association Between the Angiotensin-Converting Enzyme I/D Polymorphism and Risk of Cerebral Small Vessel Disease: A Meta-Analysis Based on 7186 Subjects
Cerebral small vessel disease (CSVD) causes a quarter of all strokes and is the most common pathology underlying vascular dementia. However, the mechanism of CSVD remains unclear. Numerous studies have investigated whether the angiotensin-converting enzyme (ACE) intersection/deletion (I/D) polymorphism influences the risk of CSVD, but the results are controversial. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 5, 2021 Category: Neurology Authors: Cheng Su, Wen-Chen Liu, Guo-Ming Li, Yan Huang Source Type: research

4-Hydroxyl-2-Nonenal Localized Expression Pattern in Retrieved Clots is Associated with Large Artery Atherosclerosis in Stroke Patients
The relationship between stroke etiology and clot pathology remains controversial. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 5, 2021 Category: Neurology Authors: Yosuke Osakada, Toru Yamashita, Ryuta Morihara, Namiko Matsumoto, Ryo Sasaki, Koh Tadokoro, Emi Nomura, Yuko Kawahara, Yoshio Omote, Nozomi Hishikawa, Mami Takemoto, Yasuyuki Ohta, Yasuki Suruga, Takayuki Nagase, Yuji Takasugi, Satoshi Inoue, Kyoichi Wata Source Type: research

Temporal Evolution and Outcomes of Non-Traumatic Intracerebral Hemorrhage in Hospitalized Patients
To investigate the radiographic features, temporal evolution, and outcome of patients who develop non-traumatic intracerebral hemorrhage (ICH) while hospitalized for other causes. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 5, 2021 Category: Neurology Authors: Andrea Loggini, Faten El Ammar, Issam A. Awad, Christos Lazaridis, Christopher L. Kramer, Christi Kordeck, Cedric McKoy, Fernando D. Goldenberg, Ali Mansour Source Type: research

Clinical Trial of the New Stent Retriever Tron FX for both Proximal and Distal Intracranial Large Vessel Occlusions
Five randomized controlled trials (RCTs)1 –5 of mechanical thrombectomy (MT) to treat large vessel occlusion (LVO) within 6 to 12 h, and 2 RCTs6,7 within 6–24 h of time last known well have clarified the its efficacy, and acute MT has spread widely and rapidly. However, the target vessels in these studies were mainly proximal large ves sels such as the intracranial internal carotid artery (ICA) and the M1 portion of the middle cerebral artery (MCA). Although the effectiveness of MT for M2/3 portion of MCA has been reported in meta-analysis8 and retrospective multicenter cohort9 studies, RCTs have not yet b...
Source: Journal of Stroke and Cerebrovascular Diseases - January 5, 2021 Category: Neurology Authors: Hirotoshi Imamura, Nobuyuki Sakai, Hiroshi Yamagami, Tetsu Satow, Yasushi Matsumoto, Keisuke Imai, Shinzo Ota, Nobutaka Horie, Rei Kondo, Yukiko Enomoto, Shinichi Yoshimura, Masaru Hirohata, Masunari Shibata, Yuji Matsumaru, Nobuyuki Ohara, Chiaki Sakai, Source Type: research

Adherence to Acute Care Measures Affects Mortality in Patients with Ischemic Stroke: The Florida Stroke Registry
Racial/ethnic disparities are recognized across all aspects of acute stroke care and underscored as an important research priority.1 –3 It has long been known that ischemic stroke has a disproportionate impact on clinical outcomes and stroke related mortality across different race/ethnic groups.4 The variations in stroke outcomes are thought to be multifactorial and in part related to differences in risk factor prevalence, reco gnition, potency and premorbid treatment of vascular related disorders in combination with age, socioeconomic status and access to care amongst different race/ethnic groups. (Source: Journal o...
Source: Journal of Stroke and Cerebrovascular Diseases - January 5, 2021 Category: Neurology Authors: Hannah Gardener, Tatjana Rundek, Judith Lichtman, Erica Leifheit, Kefeng Wang, Negar Asdaghi, Jose G. Romano, Ralph L. Sacco Source Type: research

Traumatic Distal Anterior Cerebral Artery Aneurysms – Pathomechanism and Revascularisation Strategies
The objective of this work was to discuss the mechanisms of TICA formation of the dACA and to elucidate the best treatment and revascularization strategies in these patients based on two illustrative cases. Case 1: 20-year-old patient with a traumatic, partially thrombosed 14  × 10 mm aneurysm of the right pericallosal artery (rPericA), distal to the origin of the right callosomarginal artery (rCMA). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 2, 2021 Category: Neurology Authors: Julia Velz, Giuseppe Esposito, Luca Regli Source Type: research

Gaze Deviation and Paresis Score (GPS) Sufficiently Predicts Emergent Large Vessel Occluding Strokes
The prognosis of patients with acute ischemic stroke (AIS) essentially depends on both prompt diagnosis and appropriate treatment. Endovascular stroke therapy (EST) proved to be highly efficient in the treatment of emergent large vessel occluding (ELVO) strokes in the anterior circulation. To achieve a timely diagnosis, a robust combination of few and simple signs to identify ELVOs in AIS patients applicable by paramedics in the prehospital triage is worthwhile. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 31, 2020 Category: Neurology Authors: Benedikt Johannes, Pardes Habib, Kolja Sch ürmann, Omid Nikoubashman, Martin Wiesmann, Jörg B. Schulz, Arno Reich Source Type: research

Cilostazol Versus Aspirin for Secondary Stroke Prevention: Systematic Review and Meta-Analysis
Cilostazol has promise as an alternative to aspirin for secondary stroke prevention given its vasodilatory and anti-inflammatory properties in addition to platelet aggregation inhibition. We aimed to conduct a systematic review and meta-analysis to estimate the efficacy and safety of cilostazol compared to aspirin for stroke prevention in patients with previous stroke or transient ischemic attack (TIA). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 31, 2020 Category: Neurology Authors: Michelle P. Lin, James F. Meschia, Neethu Gopal, Kevin M. Barrett, Owen A. Ross, Nil üfer Ertekin-Taner, Thomas G. Brott Source Type: research

Effective Combined Assessments of Weight Bearing Ratio and Four Square Step Test in Predicting Falls in Discharged Stroke Patients
We aimed to determine whether combined assessments of single movement tasks could predict falls in community dwelling people with stroke and it was more precision than the berg balance Scale consists of 14 movements. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 31, 2020 Category: Neurology Authors: Yoshinobu Yoshimoto, Mamoru Tanaka, Asuka Sakamoto Source Type: research

Predictive Model of Early Neurological Deterioration in Patients with Acute Ischemic Stroke: A Retrospective Cohort Study
This study aimed to develop a predictive model of early neurological deterioration (END) in patients with acute ischemic stroke (AIS). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 30, 2020 Category: Neurology Authors: Xiaohua Xie, Jingyi Xiao, Yunyun Wang, Lu Pan, Jiahui Ma, Liping Deng, Jie Yang, Lijie Ren Source Type: research

White Matter Acute Infarct Volume After Thrombectomy for Anterior Circulation Large Vessel Occlusion Stroke is Associated with Long Term Outcomes
Despite the proven efficacy of endovascular thrombectomy (EVT) for large vessel occlusion stroke, over half treated remain functionally disabled or die. Infarct topography may have implications for prognostication, patient selection, and the development of tissue-specific neuroprotective agents. We sought to quantify white matter injury in anterior circulation acute infarcts post-EVT to understand its significance and identify its determinants. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 30, 2020 Category: Neurology Authors: Robert W. Regenhardt, Mark R. Etherton, Alvin S. Das, Markus D. Schirmer, Joshua A. Hirsch, Christopher J. Stapleton, Aman B. Patel, Thabele M. Leslie-Mazwi, Natalia S. Rost Source Type: research

Malignant Left Atrial Appendage Morphology: Current Classification vs H-L System
In non-valvular atrial fibrillation (AF), more than 90% of thrombus formation occurs in the left atrial appendage (LAA).1-3 Current guidelines have established direct oral anticoagulants (DOACs) as the treatment of choice in patients with AF and high risk of stroke or transient ischemic attack (TIA), while vitamin K antagonists (VKA) can be considered in patients not suitable for DOACs.4,5 This strategy significantly reduces the risk of thromboembolism; however, there is a subset of patients that suffer recurrent embolic strokes despite appropriate anticoagulant therapy, known as malignant LAA. (Source: Journal of Stroke a...
Source: Journal of Stroke and Cerebrovascular Diseases - December 30, 2020 Category: Neurology Authors: Paloma Parra-D íaz, Luisa Salido-Tahoces, Ana Pardo-Sanz, Álvaro Beltrán-Corbellini, Fernando Rodríguez-Jorge, Juan Luis Chico-García, Sebastián García-Madrona, Consuelo Matute-Lozano, Rocío Vera-Lechuga, Antonio Cruz-Culebras, Jaime Masjuan, Alic Source Type: research

The Efficacy of Colchicine on Carotid Intima-Media Thickness: A Prospective Comparative Study
Inflammation plays an important role in the development of atherosclerotic vascular disease, which is the leading cause of morbidity and mortality in the adult population. Several clinical trials have shown that suppression of the inflammatory response can delay or decrease the atherosclerotic process. The aim of this study was to investigate carotid intima-media thickness (CIMT) between patients with chronic disease history plus gout using colchicine and patients with cardiovascular risk factors. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 30, 2020 Category: Neurology Authors: Ebru Yilmaz, Kadriye Halli Akay Source Type: research

Patient Characteristics and Outcomes Associated with Decline in Stroke Volumes during the Early COVID-19 Pandemic
Recent studies have documented a decrease in evaluations of stroke patients during the early weeks of the coronavirus disease 2019 (COVID-19) outbreak in the United States (US).1 –4 This phenomenon raises concern that delays in emergent treatment and implementation of secondary stroke prevention measures may contribute to the morbidity and mortality of the pandemic. As a second wave of COVID-19 sweeps through the country, there is an urgent need for public health communica tion that targets populations most likely to delay evaluation for stroke-like symptoms. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 25, 2020 Category: Neurology Authors: Adam N. Wallace, Kaiz S. Asif, Daniel H. Sahlein, Steven J. Warach, Timothy Malisch, E. Francis LaFranchise, Scott Geraghty, K. Derek Kreitel, Marian P. Lamonte, Jefferson T. Miley, Daniel P. Gibson, Krishna Amuluru Source Type: research

Electric Acupuncture Treatment Promotes Angiogenesis in Rats with Middle Cerebral Artery Occlusion Through EphB4/EphrinB2 Mediated Src/PI3K Signal Pathway
Cerebral infarction is one of the most common causes of disability and death worldwide. It is reported that electric acupuncture was able to improve the prognosis of cerebral infarction by promoting angiogenesis. However, the corresponding signal pathways of angiogenesis promotes by electric acupuncture treatment needs to be further explored. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 24, 2020 Category: Neurology Authors: Yuanhua Wu, Rong Hu, Xiuyan Zhong, Anbang Zhang, Bo Pang, Xiuqi Sun, Guangqi Zhu Source Type: research

Multiple Cerebrovascular Insults in Pseudoxanthoma Elasticum
Pseudoxanthoma elasticum (PXE) is a rare systemic disease with variable features, including stroke. Here, we describe a patient with PXE who developed multiple cerebrovascular pathologies decades after her diagnosis and was successfully treated with antiplatelet therapy. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 24, 2020 Category: Neurology Authors: N. Abimbola Sunmonu Tags: Case report Source Type: research

Regulatory Mechanism of MicroRNA-30b on Neonatal Hypoxic-Ischemic Encephalopathy (HIE)
This study is to investigate the role of microRNA (miR)-30b in the pathogenesis of hypoxic-ischemic encephalopathy (HIE) in neonates. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 24, 2020 Category: Neurology Authors: Weiwei Wang, Lifang Jia Source Type: research

Comparison Between Three Commonly Used Large-Bore Aspiration Catheters in Terms of Successful Recanalization and First-Passage Effect
To compare three commonly used large-bore aspiration catheters in terms of final successful recanalization rate and first-passage successful and complete recanalization rates (the so called “first-passage effect”). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 24, 2020 Category: Neurology Authors: Vittorio Semeraro, Iacopo Valente, Pietro Trombatore, Maria Porzia Ganimede, Alessandra Briatico, Carmine Di Stasi, Nicola Burdi, Giovanni Boero, Maria Pia Prontera, Prof Roberto Gandini, Sofia Vidali, Prof Marina Diomedi, Fabrizio Sallustio, Francesco D' Source Type: research

Diagnostic performances of the susceptibility vessel sign on MRI: Methodological issues
To the Editor (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 24, 2020 Category: Neurology Authors: Siamak Sabour, Hadis Ghajari Tags: Letter to the editor Source Type: research

Intravenous Thrombolysis in Acute Ischemic Stroke Patients with Unsuspected Infective Endocarditis
Infective endocarditis (IE) is considered to be an absolute contraindication for intravenous tissue plasminogen activator treatment (IVtPA) in acute ischemic stroke (AIS). However, during the hyperacute stroke evaluation, the exclusion of IE may be difficult. We sought to report the prevalence of undiagnosed IE in AIS patients who received IVtPA. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 23, 2020 Category: Neurology Authors: Mangala Gopal, Sushil Lakhani, Vivien H. Lee Tags: Case Report Source Type: research

Brain Computed Tomography Angiography Maximum Intensity Projection Images for ASPECTS Derivation and Detection of Large Infarct Volumes: Preliminary Study
In this study, we hypothesized that CTA maximum intensity projection ASPECTS (MIPSasp) would be superior compared to both NCCTasp and CTAasp in predicting FIV as measured by DWI. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 23, 2020 Category: Neurology Authors: Yu-Ming Chang, Mary Tenenbaum, Yunyun Xiong, Magdy Selim, Rafeeque Bhadelia, Lotfi Hacein-Bey, Vladimir Ivanovic Source Type: research

Elevated Urinary Titin and its Associated Clinical Outcomes after Acute Stroke
Urinary titin is a biomarker of muscle atrophy, which is a serious complication after stroke. However, there are currently no clinical data regarding urinary titin in stroke patients. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 23, 2020 Category: Neurology Authors: Manabu Ishihara, Nobuto Nakanishi, Rie Tsutsumi, Kanako Hara, Kyoka Machida, Nobuaki Yamamoto, Yasuhisa Kanematsu, Hiroshi Sakaue, Jun Oto, Yasushi Takagi Source Type: research

Down-Regulation of miR-181a-5p Prevents Cerebral Ischemic Injury by Upregulating En2 and Activating Wnt/ β-catenin Pathway
Cerebral ischemic injury contributes to severe dysfunction of the brain, which triggers extremely high mortality and disability. The role of microRNA (miR)-181a-5p is documented in cerebral ischemic injury. Therefore, this study intended to further figure out the mechanism of miR-181a-5p in cerebral ischemic injury. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 22, 2020 Category: Neurology Authors: Xiaoming Song, Yongming Xue, Hairui Cai Source Type: research

Optic Nerve and Perioptic Sheath Diameter (ONSD), Eyeball Transverse Diameter (ETD) and ONSD/ETD Ratio on MRI in Large Middle Cerebral Artery Infarcts: A Case-Control Study
The objective of this study is to analyze the contribution of optic nerve and perioptic sheath measurement on MRI to the acute phase of large middle cerebral artery infarcts. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 22, 2020 Category: Neurology Authors: Vincent Legros, Sophie Lefour, Mathieu Bard, Guillaume Giordano-Orsini, Damien Jolly, Lukshe Kanagaratnam Source Type: research

Impact of Intracranial Pressure Monitor –Guided Therapy on Neurologic Outcome After Spontaneous Nontraumatic Intracranial Hemorrhage
Objectives: Intracranial pressure (ICP) monitors have been used in some patients with spontaneous intracranial hemorrhage (ICH) to provide information to guide treatment without clear evidence for its use in this population. We assessed the impact of ICP monitor placement, including external ventricular drains and intraparenchymal monitors, on neurologic outcome in this population. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 22, 2020 Category: Neurology Authors: Sarah T. Menacho, Ramesh Grandhi, Alen Delic, Mohammad Anadani, Wendy C. Ziai, Issam A. Awad, Daniel F. Hanley, Adam de Havenon Source Type: research

Inhibitory Effects of P2Y12 Receptor Antagonist on PAR1- and PAR4-AP-Induced Platelet Aggregation in Patients with Stroke or TIA
Platelet aggregation is a key stage in the formation of arterial thrombi, which cause thrombotic events such as stroke or acute coronary syndrome, and is thus employed to evaluate platelet function and reactivity.1-3 Individual differences in platelet aggregation have been reported.4-10 Ethnic differences in platelet aggregation could explain differences in the incidences and outcomes of ischemic heart disease,2 but platelet aggregation has been associated with coronary heart disease in some epidemiological studies,3 whereas not in others. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 22, 2020 Category: Neurology Authors: Asami Kamada, Mie Shimizu, Kazumasa Oura, Makiko Yoshida, Keisuke Tsuda, Kiyotaka Oi, Yoko Ishigaku, Tatsunori Natori, Shinsuke Narumi, Ryo Itabashi, Tetsuya Maeda, Yasuo Terayama Source Type: research

A Rare Case of Oculomotor Nerve Palsy after Endovascular Treatment in a Patient with Internal Carotid Artery Dissection
We present a rare case of oculomotor nerve palsy with internal carotid artery (ICA) dissection and discuss the vascular anatomical feature of interest to be considered during treatment. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 22, 2020 Category: Neurology Authors: Seunguk Jung, Changhyo Yoon Tags: Case Report Source Type: research

Current Advances in Endovascular Treatment of Intracranial Atherosclerotic Disease and Future Prospective
Intracranial atherosclerotic disease (ICAD) is an important cause of large vessel disease leading to acute ischemic stroke (AIS). Currently, medical management such as risk factor control, antiplatelet therapy, and lifestyle changes are considered the first-line of treatment to prevent transient ischemic attack (TIA) or AIS.1 The results of the Warfarin-Aspirin Symptomatic Intracranial Disease (WASID) trial2 demonstrated that symptomatic ICAD is a high-risk cause of recurrent stroke and highlighted the need for better treatment strategies, leading to consideration for both better medical management and the possibility of a...
Source: Journal of Stroke and Cerebrovascular Diseases - December 22, 2020 Category: Neurology Authors: Mostafa Jafari, Thanh N. Nguyen, Santiago Ortega-Gutierrez, Muhammad Shazam Hussain, Ameer E. Hassan, Asad Ikram, Javed Khader Eliyas, Gustavo J. Rodriguez, Afshin A. Divani Tags: Review Article Source Type: research

Corrigendum to ‘Antiplatelet Therapy During Emergent Extracranial Internal Carotid Artery Stenting: Comparison of Three Intravenous Antiplatelet Perioperative Strategies’ [Journal of Stroke and Cerebrovascular Diseases, Vol. 30, No. 2, (2020) 105521]
The authors regret to have published in the material and methods a lower dose of Cangrelor than the one actually in use. The correct dose is as follows: an IV bolus of 30 μg/kg followed by a continuous infusion of 4μg/kg/min. The results remain unchanged. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 21, 2020 Category: Neurology Authors: Francois Delvoye, Benjamin Maier, Simon Escalard, Julien Labreuche, Laurie-Anne Thion, Soufiane Aknouche, Sol'ene Hebert, Hocine Redjem, Stanislas Smajda, Gabriele Ciccio, Julien Allard, Candice Sabben, Michael Obadia, Alain Maertens de Noordhout, Jean-Ma Tags: Corrigendum Source Type: research

Changes in Informed Consent Policy and Treatment Delays in Stroke Thrombolysis
The efficacy of thrombolytic therapy with tissue plasminogen activator (tPA) is highly time dependent. Although clinical guidelines do not recommend written informed consent as it may cause treatment delays, local policy can supersede and require it. From 2014 to 2017, three out of five public hospitals in Singapore changed from written to verbal consent at different time points. We aimed to examine the association of hospital policy changes regarding informed consent on door-to-needle (DTN) times. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 19, 2020 Category: Neurology Authors: Hanzhang Xu, Deidre Anne De Silva, Fung Peng Woon, Marcus Eng Hock Ong, David B. Matchar, Janet Prvu Bettger, Daniel T. Laskowitz, Ying Xian Source Type: research

Downregulation of lncRNA GAS5 Alleviates Hippocampal Neuronal Damage in Mice with Depression-Like Behaviors Via Modulation of MicroRNA-26a/EGR1 Axis
Accumulating evidences have demonstrated the roles of several long non-coding RNAs (lncRNAs) in depression. We aim to examine the capabilities of lncRNA growth arrest-specific transcript 5 (GAS5) on mice with depression-like behaviors and the mechanism of action. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 18, 2020 Category: Neurology Authors: Yigao Wu, Wei Rong, Qin Jiang, Ruiquan Wang, Huilan Huang Source Type: research

Association of Longitudinal Glycemia with Diffusion Weighted Imaging Lesions in Spontaneous Intracerebral Hemorrhage
Higher glycemia on admission has been associated with diffusion weighted imaging (DWI) lesions in patients with spontaneous intracerebral hemorrhage (sICH). However, the influence of longitudinal glycemia after admission and during a patient's hospitalization on DWI lesions in sICH has not been studied. Our aim was to compare longitudinal glycemia in sICH patients with and without DWI lesions. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 18, 2020 Category: Neurology Authors: Rajeev K. Garg, Bichun Ouyang, Jawad Khan, Nicholas Panos, Ivan Da Silva, Deborah Hall, Starane Shepherd, Sayona John, Mehmet Kocak, Sudeep Bhabad, Rasa Kazlauskaite, Miral Jhaveri, Thomas P. Bleck Source Type: research

A High Resolution MRI Study of the Relationship Between Plaque Enhancement and Perforator Stroke after Stenting for Symptomatic Vertebrobasilar Artery Stenosis
Perforator stroke is one of the most common complications of vertebrobasilar arterial stenting. We investigated whether perforator stroke after vertebrobasilar arterial stenting is associated with plaque enhancement in patients with severe vertebrobasilar artery stenosis. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 18, 2020 Category: Neurology Authors: Xuanzhen Lu, Cuicui Li, Changhua Qu, Jing Huang, Qunfeng Wang, Bing Qiu, Changyin Wang, Sirui Li, Haibo Xu, Yumin Liu Source Type: research

Association Between Plasma Total Homocysteine Levels and Risk of Early Hemorrhagic Transformation in Patients with Acute Ischemic Stroke: A Hospital-Based Study
In this study, we investigated the association between plasma total homocysteine(tHcy) levels and the risk of early hemorrhagic transformation(HT) in patients with acute ischemic stroke(AIS). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 17, 2020 Category: Neurology Authors: Xin Wang, Qiuju Cao, Yali Lai, Xindong Liu, Yi Zhou, Le Yang, Lijuan Zhang Source Type: research

Effect of Rhythm of Music Therapy on Gait in Patients with Stroke
This study aims to analyze the effects of rhythm of music therapy on gait in patients with ischemic stroke, and explore the value of music therapy in walking training in stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 17, 2020 Category: Neurology Authors: Yao Wang, Wei-Yi Pan, Fei Li, Jun-Sheng Ge, Xiang Zhang, Xun Luo, Yu-Long Wang Source Type: research

The Incidence and Mortality Ratio of Ischemic Cerebrovascular Accidents in Covid-19 Cases: A systematic Review and Meta-Analysis
Coronavirus disease 2019 (COVID-19) is primarily known as a respiratory illness; however, a wide variety of symptoms and complications of the central nervous system (CNS), such as ischemic cerebrovascular accidents (CVA) have been reported. Hereby, we provide a systematic review and a meta-analysis of the literature, investigating the incidence of ischemic CVA and the mortality due to it in the setting of COVID-19. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 17, 2020 Category: Neurology Authors: Sina Parsay, Armin Vosoughi, Aytak Khabbaz, Saeed Sadigh-Eteghad Tags: Original Article Source Type: research

Insulin Resistance is Significantly Related with Worse Clinical Outcomes in Non-Diabetic Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis
to investigate the relationship between insulin resistance (IR) and clinical outcomes in non-diabetic ischemic stroke patients treated with intravenous thrombolysis. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 16, 2020 Category: Neurology Authors: Xiaoli Yang, Chen Li, Jing Li, Duanlu Hou, Yufan Luo, Shufan Zhang, Zhi Jin, Liwei Shen, Ping Zhong, Danhong Wu Source Type: research

Changes in Quadriceps Thickness and Echo Intensity in Chronic Stroke Survivors: A 3-Year Longitudinal Study
There have been remarkable developments in intervention techniques for motor impairment resulting from stroke in recent years.1 Furthermore, there is increasing interest in secondary changes in the skeletal muscles in stroke survivors, including decreased muscle mass and increased intramuscular adipose tissue.2 A number of studies have also reported that the decrease in muscle mass and increase in intramuscular adipose tissue of the thigh or quadriceps is more severe on the paretic side compared with the non-paretic side. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 16, 2020 Category: Neurology Authors: Naoki Akazawa, Kazuhiro Harada, Naomi Okawa, Masaki Kishi, Kimiyuki Tamura, Hideki Moriyama Source Type: research

The Cerebro-Renal System- Anatomical and Physiological Considerations
The brain and kidney both uniquely are highly susceptible to vascular injury from shared vascular risk factors. However these are not sufficient to explain the complete extent of cerebrovascular disease especially small vessel disease in its myriad presentations that patients with chronic kidney disease manifest. They both require a large amount of blood supply to function optimally. Shared anatomical and physiological factors such as the presence of strain vessels, the local vascular autoregulation that control blood supply possible, results in the vulnerability of these organs to the vascular risk factors. (Source: Journ...
Source: Journal of Stroke and Cerebrovascular Diseases - December 16, 2020 Category: Neurology Authors: Kumar Rajamani Source Type: research

Changes in Characteristics, Treatment and Outcome in Patients with Hemorrhagic Stroke During COVID-19
The coronavirus disease 2019 (COVID-19) pandemic has had a comprehensive impact on healthcare services worldwide. We sought to determine whether COVID-19 affected the treatment and prognosis of hemorrhagic stroke in a regional medical center in mainland China. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 15, 2020 Category: Neurology Authors: Yuqi Chen, Fan Xia, Yunke Li, Hao Li, Lu Ma, Xin Hu, Chao You Source Type: research

Incremental Accuracy of Blood Biomarkers for Predicting Clinical Outcomes After Intracerebral Hemorrhage
Intracerebral hemorrhage (ICH) is associated with high mortality, morbidity, and recurrence. Studies have reported the accuracy of several blood biomarkers in predicting clinical outcomes; however, their independent contribution in prediction remains to be established. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 15, 2020 Category: Neurology Authors: Ram Sagar, Amit Kumar, Vivek Verma, Arun Kumar Yadav, Ritesh Raj, Dimple Rawat, Amarnath Yadav, Achal Kumar Srivastava, Awadh Kishor Pandit, Subiah Vivekanandhan, Arti Gulati, Garima Gupta, Kameshwar Prasad Source Type: research

A Rare Case of Eosinophilic Granulomatosis with Polyangiitis Presenting as Ischemic Stroke and Splenic Infarction
Eosinophilic Granulomatosis with Polyangiitis (EGPA) is a group of systemic disorders characterized by inflammation of blood vessels and eosinophilia. Simultaneous brain and splenic infarcts are extremely rare in patients with EGPA. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 15, 2020 Category: Neurology Authors: Ryoto Inaba, Yutaro Fuse, Futoshi Kurimoto, Susumu Suzuki, Kazuhiko Watanabe Tags: Case Report Source Type: research

Bilateral Cerebral Hyperperfusion Syndrome Following Carotid Artery Stenting in Stroke – A Case Report
Revascularization of the symptomatic carotid artery is performed with endarterectomy or stenting. Rarely, patients may develop cerebral hyperperfusion syndrome (CHS) following revascularization. This usually occurs in the cerebral hemisphere ipsilateral to revascularized carotid stenosis. CHS rarely involves the contralateral hemisphere. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 15, 2020 Category: Neurology Authors: Nandakumar Nagaraja, Manuel Viamonte, Jun Yu, Stephen C. Rohrbough Jr, Anna Y. Khanna Tags: Case Report Source Type: research

Prognostic Significance of Stroke-Associated Infection and other Readily Available Parameters in Acute Ischemic Stroke Treated by Intravenous Thrombolysis
The impact of contracting stroke-associate infection (SAI) that requires antibiotic treatment after an acute ischemic stroke (AIS) treated with alteplase remains unclear. We studied the profiles of SAI in patients with AIS treated with alteplase toward identifying predictive factors and prognostic implications at 90 days post-stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 15, 2020 Category: Neurology Authors: Justyna Derbisz, Klaudia Nowak, Marcin Wnuk, Roman Pulyk, Jeremiasz Jagiella, Joanna Slowik, Tomasz Dziedzic, Agnieszka Slowik Source Type: research

Letter to the editor regarding “clinical prediction of surgical revascularization outcome in moyamoya disease via transcranial color sonography”
We read with great interest the article by Pan et  al.1 entitled “Clinical Prediction of Surgical Revascularization Outcome in Moyamoya Disease Via Transcranial Color Sonography” recently published in Journal of Stroke and Cerebrovascular Diseases. We really appreciate the interesting observation of their conclusions. Nevertheless, after readi ng this article, we would like to highlight two questions that it raises. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 15, 2020 Category: Neurology Authors: Shuai Zheng, Peicong Ge, Wen He Tags: Letter to the Editor Source Type: research

Stroke as a Neurological Complication of COVID-19: A Systematic Review and Meta-analysis of Incidence, Outcomes and Predictors
COVID-19 is a multi-system infection which predominantly affects the respiratory system, but also causes systemic inflammation, endothelialitis and thrombosis. The consequences of this include renal dysfunction, hepatitis and stroke. In this systematic review, we aimed to evaluate the epidemiology, clinical course, and outcomes of patients who suffer from stroke as a complication of COVID-19. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - December 15, 2020 Category: Neurology Authors: Isabel Siow, Keng Siang Lee, John J.Y. Zhang, Seyed Ehsan Saffari, Adeline Ng, Barnaby Young Source Type: research