Temporal Trends in Clinical Characteristics and Door-to-Needle Time in Patients Receiving Intravenous Tissue Plasminogen Activator: A Retrospective Study of 4 Hospitals in Japan
Background: Intravenous recombinant tissue plasminogen activator (rt-PA) has become a common treatment for acute ischemic stroke and has highly time-dependent benefits. We aimed to clarify temporal trends regarding the frequency and characteristics of patients receiving rt-PA and explore factors associated with door-to-needle time (DNT) in Japanese emergency hospitals. Methods: Consecutive patients who received intravenous rt-PA for acute ischemic stroke from October 2005 to December 2015 were retrospectively registered from 4 hospitals. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 10, 2019 Category: Neurology Authors: Koji Tanaka, Shoji Matsumoto, Takeshi Yamada, Sukehisa Nagano, Kei-ichiro Takase, Taketo Hatano, Ryo Yamasaki, Jun-ichi Kira Source Type: research

Development and Validation of an Exercise Programme for Recovery Balance Impairments in Poststroke Patients
Background: Deterioration of balance is one of the most common and disabling physical-motor deficits in patients after a stroke that have a negative impact on quality of life and increase the risk of falls. Previous studies have evaluated the effectiveness of the exercises on specific aspects of balance. However, there is no structured exercise program divided by levels for balance impairment in poststroke patients. Methods: Delphi method was used to design the exercise programme, and then a pilot study was performed. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 10, 2019 Category: Neurology Authors: Almudena Medina-Rinc ón, Caritat Bagur-Calafat, Laura M. Pérez, Ana M. Barrios-Franquesa, Montserrat Girabent-Farrés Source Type: research

Acute Ischemic Stroke with Vessel Occlusion —Prevalence and Thrombectomy Eligibility at a Comprehensive Stroke Center
Introduction: Endovascular thrombectomy (ET) for acute ischemic stroke (AIS) caused by large vessel occlusion (LVO) can prevent severe disability and mortality. There is currently limited data on the epidemiology of LVO strokes and ET eligibility. We aim to determine the incidence of intracranial vessel occlusion (IVO) strokes eligible for ET per 2018 American Heart Association (AHA) guidelines and characteristics of an AHA ineligible population at a comprehensive stroke center (CSC). Methods: Retrospective chart review of all consecutive AISs at a CSC between November 2014 and February 2017. (Source: Journal of Stroke and...
Source: Journal of Stroke and Cerebrovascular Diseases - August 10, 2019 Category: Neurology Authors: Shashvat M. Desai, Matthew Starr, Bradley J. Molyneaux, Marcelo Rocha, Tudor G. Jovin, Ashutosh P. Jadhav Source Type: research

Dural Sinus Thrombosis with Nonsymptomatic Persistent Falcine Sinus: A Case Report
A 24-year-old woman was admitted to our hospital after convulsive status epilepticus. A cerebral magnetic resonance venography revealed a persistent fetal falcine sinus. Additionally, the posterior third of the superior sagittal sinus was hypoplastic and the abnormal deep venous drainage was accompanied. These abnormalities had already been detected by magnetic resonance imaging several years ago. In the present scan, we discovered a sinus thrombosis in the hypoplastic superior sagittal sinus. In the cerebral angiography, we observed delayed venous return in the left parieto-occipital lobe and hypothesized that cerebral ve...
Source: Journal of Stroke and Cerebrovascular Diseases - August 9, 2019 Category: Neurology Authors: Ayako Shioya, Ryota Mashiko, Masanari Shiigai, Yasunobu Nakai, Nobuyuki Takahashi, Hiroyuki Kobayashi, Toshiyuki Irie, Akira Tamaoka Tags: Case Report Source Type: research

Fever Burden in Patients With Subarachnoid Hemorrhage and the Increased Use of Antibiotics
Background: Fever occurs in the majority of subarachnoid hemorrhage (SAH) patients. Nearly 50% of SAH patients have noninfectious fevers. Data are lacking describing the effects of fever burden in the SAH patient population. Methods: This was a single-center, retrospective observational cohort study in patients more or equal to 18 years of age with a diagnosis of nontraumatic SAH admitted to an ICU between January 1, 2010 and September 1, 2015. Exclusion criteria were SAH secondary to trauma or admission for more than 48 hours. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 9, 2019 Category: Neurology Authors: Carolyn A Magee, Melissa L. Thompson Bastin, Katelyn Graves, Donna Burgess, Melissa Nestor, John R. Lamm, Aaron M. Cook Source Type: research

Intraoperative Aneurysm Rupture during Resection for Presumed Metastasis
A 54-year-old male with metastatic melanoma, including a presumed brain metastasis underwent elective surgery when there was sudden onset of extensive bleeding upon resection. An emergent cerebral angiogram revealed a fusiform left posterior cerebral artery aneurysm. Malignant melanoma commonly metastasizes to the brain and has shown to assume a wide variety of appearances with involvement of almost any intracranial structures. The unexpected intraoperative finding required immediate action and strategic rethinking. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 9, 2019 Category: Neurology Authors: Anna L. K ühn, Katyucia de Macedo Rodrigues, Ajit S. Puri Tags: Case Report Source Type: research

Migraine History: A Predictor of Negative Diffusion-Weighted Imaging in IV-tPA-Treated Stroke Mimics
Background: Migraine, seizures, and psychiatric disorders are frequently reported as “stroke mimics” in patients with negative diffusion-weighted imaging (DWI) after IV-tPA. We sought to determine predictors of negative DWI in suspected stroke patients treated with IV-tPA. Method: A retrospective case-control study encompassing all acute stroke patients treated with IV-tPA (at o ur hospital or “dripped and shipped”) from January 2013 to December 2014 was con- ducted. A total of 275 patients were identified with 47 negative DWI cases and 228 positive DWI controls. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 8, 2019 Category: Neurology Authors: Jussie Lima, Tapan Mehta, Neil Datta, Ekaterina Bakradze, Ilene Staff, Dawn Beland, Amre Nouh Source Type: research

Educating Stroke/TIA Patients about Obstructive Sleep Apnea after Stroke: A Randomized Feasibility Study
This study aimed to develop and conduct a preliminary assessment of educational materials for poststroke/TIA OSA. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 7, 2019 Category: Neurology Authors: Laavanya Dharmakulaseelan, Nardin Kirolos, Maneesha Kamra, Armi Armesto-Heys, Cathy Bouthillier, Sharron Runions, Elizabeth Linkewich, Brian J. Murray, Mark I., Boulos Source Type: research

Clematichinenoside Facilitates Recovery of Neurological and Motor Function in Rats after Cerebral Ischemic Injury through Inhibiting Notch/NF- κB Pathway
Purpose: The present study was to observe the therapeutic efficiency of Clematichinenoside (AR) on cerebral ischemic injury in rats, especially on neurological and motor function recovery and to explore the underlying mechanism. Methods: Following middle cerebral artery occlusion/reperfusion (MCAO/R) surgery, rats were treated orally with 32, 16, and 8 mg/kg AR respectively for 14 days during which cerebral injury was evaluated and proinflammatory factors tumor necrosis factor- α and interleukin-6 as well as neurotrophic factors brain-derived neurotrophic factor and Neurotrophin-3 levels were determined with ELISA ki...
Source: Journal of Stroke and Cerebrovascular Diseases - August 6, 2019 Category: Neurology Authors: Dan Xu, Nian Xia, Kai Hou, Fengyang Li, Shijie Chen, Yahui Hu, Weirong Fang, Yunman Li Source Type: research

The Effect of Continuous Theta-Burst Transcranial Magnetic Stimulation Combined with Prism Adaptation on the Neglect Recovery in Stroke Patients
This study was designed to investigate the effect of prism adaptation (PA) combined with continuous theta-burst transcranial magnetic stimulation (cTBS) on the neglect recovery of stroke patients with unilateral neglect. Methods: A total of 14 stroke patients with unilateral neglect were randomly assigned to 2 groups including an intervention group undergone PA combined with cTBS over the left intact parietal cortex and a control group. PA combined with sham cTBS was perfomed for 2 weeks in 10 daily sessions. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 6, 2019 Category: Neurology Authors: Shole Vatanparasti, Anoshirvan Kazemnejad, Ali Yoonessi, Shahram Oveisgharan Source Type: research

Imaging Classification of Internal Carotid Artery Hypoplasia Based on Distal Ophthalmic Segment Occlusion
Background: Internal carotid artery (ICA) hypoplasia (ICAH) is rare. The classification of ICAH is largely unclear. The aim of the study is to propose a new imaging classification for ICAH based on the occlusion of the distal ophthalmic segment and discuss the clinical and radiological differences between the different types. Materials and Methods: This was a retrospective study of patients with congenital ICAH diagnosed at the Department of Neurology of the China-Japan Friendship Hospital between June 2011 and June 2016. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 6, 2019 Category: Neurology Authors: Zhiyong Zhang, Zhiqin Liu, Zunjing Liu Source Type: research

Pre-Existing Cerebral Small Vessel Disease Limits Early Recovery in Patients with Acute Lacunar Infarct
Background and Purpose: To assess whether neuroimaging markers of chronic cerebral small vessel disease (cSVDm) influence early recovery after acute ischemic stroke (AIS). Methods: Retrospective analysis of patients diagnosed with AIS and included in the Spanish Neurological Society Stroke Database. Inclusion criteria: (1) Brain MRI performed after acute stroke and (2) Premorbid modified Rankin scale (mRS)  = 0. Exclusion criteria: (1) Uncommon stroke etiologies, (2) AIS not confirmed on neuroimaging, or (3) Old territorial infarcts on neuroimaging. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 5, 2019 Category: Neurology Authors: Manuel G ómez-Choco, Juan José Mengual, Jon Rodríguez-Antigüedad, Martí Paré-Curell, Francisco Purroy, Ernest Palomeras, Blanca Fuentes, Xavier Ustrell, José Tembl, Manuel Rodríguez-Yañez, Mar Castellanos, Joan Martí-Fabregas, Joaquín Serena Source Type: research

Older Age Is Not Associated with Worse Outcomes Following Decompressive Hemicraniectomy for Spontaneous Intracerebral Hemorrhage
Background: Decompressive hemicraniectomy (DHC) is commonly offered after large spontaneous intracerebral hemorrhage (ICH) as a life-saving measure. Based on limited available evidence, surgery is sometimes avoided in the elderly. The association between age and outcomes following DHC in spontaneous ICH remains largely understudied. Objective: The goal of this study is to investigate the influence of older age on outcomes of patients who undergo DHC for spontaneous ICH. Methods: In this retrospective cohort study, inpatient data were obtained from the United States Nationwide Inpatient Sample from 2000 to 2011. (Source: Jo...
Source: Journal of Stroke and Cerebrovascular Diseases - August 5, 2019 Category: Neurology Authors: Roy A. Poblete, Ling Zheng, Marcela Arenas, Alejandro Vazquez, Derek Yu, Benjamin A. Emanuel, May A. Kim-Tenser, Nerses Sanossian, William Mack Source Type: research

Prognostic Value of Clot Burden Score in Acute Ischemic Stroke after Reperfusion Therapies: A Systematic Review and Meta-Analysis
Background and Aim: Clot burden score (CBS) was designed to weight the thrombus status in cerebral anterior circulation. We performed a systematic review and meta-analysis to investigate the prognostic value of CBS in acute ischemic stroke (AIS) patients undergoing reperfusion therapies. Methods: We searched relevant databases for eligible articles reporting CBS in AIS patients. The effect sizes of good functional outcome, recanalization, or hemorrhagic transformation (HT) were pooled with random-/fixed-effect models. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 3, 2019 Category: Neurology Authors: Guoming Li, Guangliang Wu, Zhengjie Qin, Huiping Li, Xiao Cheng, Yefeng Cai Source Type: research

Twendee X Ameliorates Phosphorylated Tau, α-Synuclein and Neurovascular Dysfunction in Alzheimer's Disease Transgenic Mice With Chronic Cerebral Hypoperfusion
Background: The pathological impact of chronic cerebral hypoperfusion (CCH) on Alzheimer's disease (AD) is still poorly understood. In the present study, we investigated the role of CCH on an AD mouse model in phosphorylated tau and α-synuclein pathology, neurovascular unit, cerebrovascular remodeling, and neurovascular trophic coupling. Moreover, examined protective effect of a new antioxidant Twendee X (TwX). Methods: APP23 mice were implanted to bilateral common carotid arteries stenosis with ameroid constrictors to gradual ly decrease the cerebral blood flow. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 3, 2019 Category: Neurology Authors: Xia Liu, Toru Yamashita, Jingwei Shang, Xiaowen Shi, Ryuta Morihara, Yong Huang, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Koji Abe Source Type: research

A Case of Juvenile Stroke due to Carotid Artery Dissection from an Elongated Styloid Process —Revisiting Conservative Management
Carotid artery dissection is a significant etiology of juvenile stroke. Blunt trauma from an elongated styloid process can rarely cause carotid artery dissection, which is one of well-known clinical presentations of Eagle's syndrome as known as stylocarotid syndrome. Growing number of publications contributed improved awareness and diagnostic modalities for this clinical entity, thus the carotid artery dissection from an elongated styloid process is often diagnosed appropriately. The management of carotid artery dissection in stylocarotid syndrome tends to be nonconservative (ie, removal of the process or carotid stenting)...
Source: Journal of Stroke and Cerebrovascular Diseases - August 2, 2019 Category: Neurology Authors: Takafumi Shindo, Masaki Ito, Juntaro Matsumoto, Koichi Miki, Fumiaki Fujihara, Shunsuke Terasaka, Toyohiko Isu, Masanori Isobe Tags: Case Report Source Type: research

Retraction notice to “Beneficial Effect of Etidronate Therapy in Chronically Hospitalized, Disabled Patients with Stroke” [Journal of Stroke and Cerebrovascular Diseases, Volume 19, Issue 3, May 2010, Pages 198-203]
Available online: 29 April 2010 (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 31, 2019 Category: Neurology Authors: Yoshihiro Sato, Jun Iwamoto, Yoshiaki Honda Tags: Retraction notice Source Type: research

Masthead
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 31, 2019 Category: Neurology Source Type: research

Editorial Board
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 31, 2019 Category: Neurology Source Type: research

Table of Contents
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 31, 2019 Category: Neurology Source Type: research

Intracerebral Hemorrhage in a Young Urban Population: Etiologies and Outcomes in Patients 50 and Younger
Goal: There is limited research on intracerebral hemorrhage in young urban populations. There is reduced access to healthcare and a high prevalence of multiple comorbidities in this vulnerable population. We studied the etiologies and outcomes of spontaneous intracerebral hemorrhage in an urban North Philadelphia cohort aged 50 years old and younger. Materials and methods: A retrospective chart review of subjects 50 years old and younger who presented with spontaneous intracerebral hemorrhage at Temple University Hospital was conducted. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 31, 2019 Category: Neurology Authors: Aron Gedansky, Paul Jarvis, Daohai Yu, Xiaoning Lu, Terry Heiman-Patterson, Guillermo Linares Source Type: research

Aspiration Catheter Reach to Thrombus (ART) Sign in Combined Technique for Mechanical Thrombectomy: Impact for First-Pass Complete Reperfusion
Objective: The important factor for successful first-pass complete reperfusion (FPR) after combined techniques for mechanical thrombectomy (MT) is unclear. We consider that for successful FPR, the aspiration catheter (AC) should reach to and hold the thrombus before the device is pulled out. Therefore, we defined an ART (AC reached thrombus) sign characterized by the cessation of reverse blood flow in aspiration pump and deformation of stent retriever (SR) at the tip of AC. The purpose of this study was to identify the impact of the ART sign on the outcomes of the combined techniques. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 31, 2019 Category: Neurology Authors: Taichiro Mizokami, Takeshi Uwatoko, Kenichi Matsumoto, Yuichiro Ooya, Go Hashimoto, Motofumi Koguchi, Hideki Iwashita, Kiku Uwatoko, Hiroshi Takashima, Hiroshi Sugimori, Syuji Sakata Source Type: research

CT-based Higher Thrombus Density is associated with Secondary Embolism during Mechanical Thrombectomy: A Preliminary Observation
This study addresses a potential relationship between thrombus density on preinterventional computed tomography (CT) and the occurrence of SE. Methods: We reviewed anterior circulation AIS patients who underwent MT from July 2015 to January 2019 in our center. Thrombus density was measured in Hounsfield Units (HU) on 1-mm and 5-mm preinterventional nonenhanced CT (NECT). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 31, 2019 Category: Neurology Authors: Gengfan Ye, Ruoyao Cao, Jun Lu, Peng Qi, Juan Chen, Daming Wang Source Type: research

Re Alarming Results for Carotid Artery Stenting in Patients with Contralateral Carotid Artery Occlusion
Thank you for the interest in our data. Although the 3-year stroke, Myocardial Infarction (MI), or death rates in the entire cohort of 49 patients was relatively high (18.4%), the majority of patients less than 75 years old had a stroke rate of 5% and a stroke-MI-death rate of 10.5% over 3 years. We agree that these data are not as good as carotid endarterectomy (CEA), but we stand by our conclusion that carotid artery stenting (CAS) in patients with contralateral carotid artery occlusion (CCO) is a safe and effective therapy. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 30, 2019 Category: Neurology Authors: Jianming Guo, Alan Dardik, Yongquan Gu Tags: Letter to the Editor Source Type: research

Resumption of Direct Oral Anticoagulants in Patients with Acute Spontaneous Intracerebral Hemorrhage
We examined the timing of DOAC resumption and factors that influence decision-making in DOAC resumption. Methods: We retrospectively analyzed 43 patients with ICH who were treated with DOAC for nonvalvular atrial fibrillation before ICH onset. All patients were divided into 2 groups (resumption of DOAC and no resumption of DOAC) during hospitalization. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 30, 2019 Category: Neurology Authors: Yuji Kato, Takeshi Hayashi, Kaima Suzuki, Hajime Maruyama, Yuichiro Kikkawa, Hiroki Kurita, Masaki Takao Source Type: research

Cognitive Rehabilitation Improves Ischemic Stroke-Induced Cognitive Impairment: Role of Growth Factors
Cognitive dysfunction is the most common nonphysical impairment in the stroke survivors. This impairment has a negative impact on patients ’ quality of life affects their daily living activities. Both pharmacological and nonpharmacological interventions are employed to improve cognitive impairment. Recently, nonpharmacological interventions have attracted great attention. Cognitive rehabilitation is considered as a therapeutic strate gy to improve and maintain cognitive skills in patients with stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 30, 2019 Category: Neurology Authors: Fatemeh Farokhi-Sisakht, Mehdi Farhoudi, Saeed Sadigh-Eteghad, Javad Mahmoudi, Gisou Mohaddes Tags: Review Article Source Type: research

Safety and Efficacy of Repeated Thrombolysis with Alteplase in Early Recurrent Ischemic Stroke: A Systematic Review
Background and Aim: The current American Heart Association guidelines for the management of acute ischemic stroke advise against the use of intravenous (IV) alteplase in patients with recurrent stroke occurring within 90 days of their index event. Following these guidelines strictly, patients having early recurrent ischemic stroke would be unable to avail of this reperfusion strategy that has been proven to confer superior clinical outcomes. While some registry-based studies have demonstrated the safety of IV alteplase in this subgroup of patients, data on the repeated use of the drug are lacking. (Source: Journal of Strok...
Source: Journal of Stroke and Cerebrovascular Diseases - July 29, 2019 Category: Neurology Authors: Robert Joseph Cruz Sarmiento, Jose Danilo Bengzon Diestro, Adrian Isidoro Espiritu, Maria Cristina Zarsadias San Jose Source Type: research

Proximal Common Carotid Artery Stenosis Induced by Repetitive Mechanical Compression: A Case Report
Objectives: Arterial branches and curvatures, such as the common carotid artery (CCA) origin and carotid bifurcation, are usual sites of atherosclerosis, which leads to carotid artery stenosis. Atherosclerosis may occur due to repetitive compression. Stenosis localized to the proximal segment away from the CCA origin and bifurcation is rare. Here, we describe the case of a patient with right proximal CCA stenosis induced by repetitive compression. Methods: We studied an acute stroke patient who worked for a long time as a geographical surveyor carrying a tripod on his right shoulder. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 29, 2019 Category: Neurology Authors: Takuya Saito, Ryo Itabashi, Yuya Kobayashi, Yuichi Kawabata, Yukako Yazawa Tags: Case Report Source Type: research

Discovery of a novel mutation in the REN gene in patient with chronic progressive kidney disease of unknown etiology presenting with acute spontaneous carotid artery dissection
We report on a 36-year-old male with the right internal carotid artery dissection and a novel genetic variant in the REN gene. Our report offers evidence that mutations in the REN gene could have pathogenic role in arterial dissection. The subject gave written informed consent for the publication of this case report. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 29, 2019 Category: Neurology Authors: Timotej Petrijan, Marija Menih Tags: Case Report Source Type: research

Toward Improving Poststroke Aphasia: A Pilot Study on the Growing Use of Telerehabilitation for the Continuity of Care
Background: Aphasia is a quite common and very disabling symptom following stroke, negatively affecting patient's quality of life. Aim of the study is to evaluate the effectiveness of a rehabilitation training for aphasia that employ a touch-screen tablet using a virtual reality rehabilitation system (VRRS-Tablet). Material and Methods: Thirty patients with aphasia due to ischemic or hemorrhagic stroke were randomized into either the control or the experimental group and assessed by means of a specific neuropsychological evaluation. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 29, 2019 Category: Neurology Authors: Giuseppa Maresca, Maria Grazia Maggio, Desiree Latella, Antonino Cannav ò, Maria Cristina De Cola, Simona Portaro, Maria Chiara Stagnitti, Giuseppe Silvestri, Michele Torrisi, Alessia Bramanti, De Luca Rosaria, Rocco Salvatore Calabrò Source Type: research

Initial National Institute of Health Stroke Scale to Early Predict the Improvement of Swallowing in Patients with Acute Ischemic Stroke
Objectives: To study the applicability of National Institutes of Health Stroke Scale (NIHSS) in early predicting the prognosis of poststroke dysphagia in an acute ward. Methods: This is an observational retrospective cohort study including adult patients with ischemic stroke. Patients with various factors affecting swallowing were excluded to obtain a representative sample of 165 patients. The main outcome measure was the improvements of oral intake function. Results: The scores of facial palsy (NIHSS item 4) (odds ratio [OR]: 0.484, 95% confidence interval [CI]: 0.279-0.838, P = .0096] and language/aphasia (NIHSS item 9) ...
Source: Journal of Stroke and Cerebrovascular Diseases - July 27, 2019 Category: Neurology Authors: Wen-Chih Lin, Chih-Yuan Huang, Lin-Fu Lee, Yun-Wen Chen, Chung-Han Ho, Yuan-Ting Sun Source Type: research

Correlation Between Cerebral Microbleeds and Vulnerable Plaque in Patients with Severe Carotid Artery Stenosis; Comparative Magnetic Resonance Imaging Study
This study was aimed to evaluate the correlation between microbleeds and carotid plaque characteristics. Materials and Methods: This study enrolled 85 patients who underwent surgical/endovascular treatments for carotid artery stenosis between January 2009 and July 2016. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 27, 2019 Category: Neurology Authors: Satoshi Hori, Emiko Hori, Takashi Shibata, Kimiko Umemura, Soushi Okamoto, Michiya Kubo, Yukio Horie, Satoshi Kuroda Source Type: research

Factors Associated With In-Hospital Mortality in Very Elderly Patients With Ischemic Stroke: A Cohort Study
The highest mortality rates associated with ischemic stroke occur in patients of advanced age. However, studies of factors that establish the increase in hospital mortality are scanty in this population. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 25, 2019 Category: Neurology Authors: Am érico Danúzio Pereira de Oliveira, Luciana Patrizia Alves de Andrade-Valença, Marcelo Moraes Valença Source Type: research

Pure Cortical Stroke Causing Hemichorea-Hemiballismus
We report a case of a 72-year-old man with vascular risk factors who presented with acute onset right-sided hemichorea-hemiballism. Metabolic-, infectious-, and toxic-related conditions were ruled out, his EEG was without epileptiform changes. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 25, 2019 Category: Neurology Authors: Sara Strauss, Daniel Rafie, Anitha Nimma, Raquel Romero, Philip A. Hanna Tags: Case Report Source Type: research

Prevalence of Nonstenotic Carotid Plaque in Stroke Due to Atrial Fibrillation Compared to Embolic Stroke of Undetermined Source
Background: Embolic stroke of undetermined source (ESUS) accounts for about 20% of strokes. Nonstenotic cervical arterial plaque may be a mechanism of stroke in a subset of these patients. Methods: A cohort of consecutive patients with ischemic stroke was retrospectively identified from a stroke registry. Patients with unilateral anterior circulation embolic stroke due to atrial fibrillation (AF) or consistent with ESUS who underwent computed tomographic neck angiography were included. The prespecified primary outcome was a comparison of the prevalence of carotid plaque greater than or equal to 3 mm thickness ipsilateral v...
Source: Journal of Stroke and Cerebrovascular Diseases - July 25, 2019 Category: Neurology Authors: James E. Siegler, Jesse M. Thon, John H. Woo, David Do, Steven R. Mess é, Brett Cucchiara Source Type: research

Asian Study of Cerebral Venous Thrombosis
The objective of the present study is to identify risk factors, presentation, and outcome of CVT in Asian patients. Methods: Asian CVT registry is a prospective multinational observational study that included patients (aged> 16 years) with symptomatic CVT. Results: Eight hundred and twelve patients (59% women) from 20 centers in 9 Asian countries were included. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 24, 2019 Category: Neurology Authors: Mohammad Wasay, Subash Kaul, Bindu Menon, Alper I. Dai, Mohammad Saadatnia, Abdul Malik, Ahmed Khalifa, Afshin Borhani-Haghigi, Manmohan Mehndiratta, Maria Khan, Nimalendu Bikash Bhowmik, Safia Awan Source Type: research

Increased Spot Urine Albumin-to-Creatinine Ratio and Stroke Incidence: A Systematic Review and Meta-Analysis
This study aimed to clarify the association between an increased spot urine albumin-to-creatinine ratio (UACR) and the risk of stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 23, 2019 Category: Neurology Authors: Ruolan Huang, Xiaowu Chen Tags: Review Article Source Type: research

Improvement in Microregional Oxygen Supply/Consumption Balance and Infarct Size After Cerebral Ischemia-Reperfusion With Inhibition of p70 Ribosomal S6 Kinase (S6K1)
Background: We tested the hypothesis that inhibition of p70 ribosomal S6 kinase (S6K1) would decrease infarct size and improve microregional O2 supply/consumption balance after cerebral ischemia-reperfusion. Methods: This was tested in isoflurane-anesthetized rats with middle cerebral artery blockade for 1 hour and reperfusion for 2 hours with or without PF-4708671 (S6K1 inhibitor, 75 mg/kg, 15 minutes after blockade). Regional cerebral blood flow was determined using a C14-iodoantipyrine autoradiographic technique. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 23, 2019 Category: Neurology Authors: Harvey R. Weiss, Scott J. Mellender, Geza K. Kiss, Xia Liu, Oak Z. Chi Source Type: research

Intravenous Thrombolysis and Mechanical Thrombectomy in Patients with Stroke after TAVI: A Report of Two Cases
We describe 2 cases of patients with stroke after TAVI who received tPA therapy and mechanical thrombectomy. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 18, 2019 Category: Neurology Authors: Lucio D'Anna, Ozan Demir, Soma Banerjee, Iqbal Malik Tags: Case Report Source Type: research

Early Prognostication of 1-Year Outcome After Subarachnoid Hemorrhage: The FRESH Score Validation
Background and Aim: The FRESH score is a tool to prognosticate long-term outcomes after spontaneous subarachnoid hemorrhage (SAH). Here, for the first time, we aimed to externally validate the disability part of FRESH using its original four score variables. Methods: A total of 107 patients with SAH were prospectively enrolled in the Yale Acute Brain Injury Biorepository between September 2014 and January 2018. 12-month functional outcome was recorded prospectively by trained study investigators using the modified Rankin Scale (mRS). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 18, 2019 Category: Neurology Authors: Jens Witsch, Lindsey Kuohn, Ryan Hebert, Branden Cord, Lauren Sansing, Emily J. Gilmore, David Y. Hwang, Nils Petersen, Guido J. Falcone, Charles Matouk, Kevin N. Sheth Source Type: research

Ischemic Stroke Associated With Calcitonin Gene-Related Peptide Inhibitor Therapy for Migraine: A Case Report
We describe a 41-year-old woman with migraine without aura who developed a right thalamic infarction following a first dose of erenumab, a CGRP-receptor blocker. Stroke onset occurred during a typical migraine. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 18, 2019 Category: Neurology Authors: Stephen Aradi, Eric Kaiser, Brett Cucchiara Tags: Case Report Source Type: research

A Therapeutic International Normalized Ratio Results in Smaller Infarcts and Better Outcomes for Patients with Ischemic Stroke
Background: Prior studies have shown that warfarin is effective for both primary and secondary stroke prevention in individuals with atrial fibrillation. It is also known that those on warfarin with atrial fibrillation often have poorer long-term poststroke outcomes, possibly because cardioembolic strokes tend to be larger and more severe. Less is known regarding the direct effect of the international normalized ratio (INR) value at the time of stroke on severity or long-term functional status. Methods: We prospectively followed a consecutive series of 112 patients presenting to our institution with acute ischemic stroke b...
Source: Journal of Stroke and Cerebrovascular Diseases - July 17, 2019 Category: Neurology Authors: Dawn Merbach, Erin Lawrence, Dania Mallick, Elisabeth B. Marsh Source Type: research

Thrombolysis Following Heparin Reversal With Protamine Sulfate in Acute Ischemic Stroke: Case Series and Literature Review
Administering intravenous IV tissue plasminogen activator (tPA) is the recommended standard of care in acute ischemic stroke (AIS), although it is not recommended to administer intravenous thrombolysis with tPA following heparin reversal with protamine sulfate in patients with AIS. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 17, 2019 Category: Neurology Authors: Tamra Ranasinghe, Traci Mays, Jeff Quedado, Amelia Adcock Source Type: research

Letter to the Editor Regarding “Bioccipital Lobe Hypoperfusion and Anton's Syndrome Resolution with Intravenous Thrombolysis”
We have read with great interest the article by Rotkopf et al.1 The authors presented a rare case of Anton's syndrome confirmed by multiparametric computed tomography (CT) and completely resolved after the administration of recombinant tissue plasminogen activator (rtPA). We absolutely agree with the authors that multiparametric CT imaging may aid in quickly proving the underlying stroke in Anton's syndrome, especially helpful considering the discrepancy between the patient's perception and clinical examination results. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 15, 2019 Category: Neurology Authors: Shugang Cao, Xiaoxing Ni, Wen'an Xu Tags: Letter to the Editor Source Type: research

Centrally Guided Identification of Patients With Large Vessel Occlusion: Lessons From Trauma Systems
Objective: Improve prehospital identification of acute ischemic stroke patients with large vessel occlusion (LVO) by using a trauma system-based emergency communication center (ECC) to guide the emergency medical service (EMS). Methods: We trained 24 ECC paramedics in the Emergency Medical Stroke Assessment (EMSA). ECC-guided EMS in performance of the EMSA on patients with suspected stroke. During the second half of the study, we provided focused feedback to ECC after reviewing recorded ECC-EMS interactions. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 15, 2019 Category: Neurology Authors: Toby I. Gropen, Melissa Gazi, Michael Minor, Abimbola Fadairo, Joe Acker Source Type: research

Risk Factors for Cerebral Infarction in Duchenne Muscular Dystrophy: Review With our 2 Cases
Background: Although the incidence of cerebral infarction is higher in Duchenne muscular dystrophy (.75 per 100) than in the general population (7.5-11.4 per 100 000), only 18 cases have been reported, and prevention and management guidelines for infarction in this disorder remain lacking. Patients and Methods: We encountered 2 cases of Duchenne muscular dystrophy with cerebral infarction. To clarify risk factors for such infarction in Duchenne muscular dystrophy, we reviewed 20 cases, including our 2 patients. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 13, 2019 Category: Neurology Authors: Fumihito Nozaki, Takashi Kusunoki, Tomohiro Kumada, Minoru Shibata, Tatsuya Fujii Source Type: research

Association between Bilateral Infarcts Pattern and Detection of Occult Atrial Fibrillation in Embolic Stroke of Undetermined Source (ESUS) Patients with Insertable Cardiac Monitor (ICM)
Increasingly, insertable cardiac monitors (ICM) have been used to detect Atrial Fibrillation (AF) in patients with cryptogenic stroke or embolic strokes of undetermined source (ESUS). We aim to examine the characteristics of these patients who were subsequently found to have AF. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 13, 2019 Category: Neurology Authors: Boi Yushan, Benjamin Y.Q. Tan, Nicholas Jinghao Ngiam, Bernard P.L. Chan, Teoh Hock Luen, Vijay K. Sharma, Ching-Hui Sia, Mayank Dalakoti, Seow Swee Chong, Pipin Kojodjojo, Leonard L.L. Yeo Source Type: research

Randomized Controlled Trial of Gait Training Using Gait Exercise Assist Robot (GEAR) in Stroke Patients with Hemiplegia
This trial aimed to validate the effectiveness of using the Gait Exercise Assist Robot (GEAR) in patients with hemiplegia after primary stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 13, 2019 Category: Neurology Authors: Ken Tomida, Shigeru Sonoda, Satoshi Hirano, Akira Suzuki, Genichi Tanino, Kenji Kawakami, Eiichi Saitoh, Hitoshi Kagaya Source Type: research

Higher Coated-Platelet Levels in Acute Stroke are Associated with Lower Cognitive Scores at Three Months Post Infarction
We examined whether coated-platelet levels measured at the time of the stroke correlate with cognitive scores at 3 months following the brain infarction. Methods: Coated-platelets were assayed in consecutive patients with nonlacunar stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 13, 2019 Category: Neurology Authors: Angelia C. Kirkpatrick, Julie A. Stoner, George L. Dale, Meheroz Rabadi, Calin I. Prodan Source Type: research

Integration of Real-Time Electronic Health Records and Wireless Technology in a Mobile Stroke Unit
Background: UCHealth's Mobile Stroke Unit (MSU) at University of Colorado Hospital is an ambulance equipped with a computed tomography (CT) scanner and tele-stroke capabilities that began clinical operation in Aurora, Colorado January 2016. As one of the first MSU's in the United States, it was necessary to design unique and dynamic information technology infrastructure. This includes high-speed cellular connectivity, Health Insurance Portability and Accountability Act compliance, cloud-based and remote access to electronic medical records (EMR), and reliable and rapid image transfer. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 12, 2019 Category: Neurology Authors: Brandi Schimpf, Kathy Deanda, David A. Severenuk, Tara M. Montgomery, Gregory D. Cooley, Robert G. Kowalski, Daniel Vela-Duarte, William J. Jones Source Type: research