Elevated Creatinine-Based Estimated Glomerular Filtration Rate is Associated with Increased Risk of Sarcopenia, Dysphagia, and Reduced Functional Recovery after Stroke
To evaluate the associations between estimated glomerular filtration rate (eGFR) and sarcopenia and functional outcomes after stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 27, 2020 Category: Neurology Authors: Yoshihiro Yoshimura, Hidetaka Wakabayashi, Fumihiko Nagano, Takahiro Bise, Sayuri Shimazu, Ai Shiraishi Source Type: research

Significance of Cycle Ergometer as a Measure of Peak Aerobic Capacity in the Disabled
To compare different physiological responses between treadmill and cycle ergometer in stroke patients in regard to community ambulation, and to determine strong predictors of equipment-dependent VO2peak and its related factors among physical fitness parameters and finally to establish the significance of cycle ergometer as a measure of VO2peak in the disabled according to gait function. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 26, 2020 Category: Neurology Authors: Ho Min Yoon, Eun Young Han, Seung-Jae Joo Source Type: research

Treatment Approaches and Outcomes for Acute Anterior Circulation Stroke Patients with Tandem Lesions
Endovascular thrombectomy (EVT) has revolutionized stroke care for large vessel occlusions (LVOs). However, over half treated remain functionally disabled or die. Patients with tandem lesions, or severe stenosis/occlusion of the cervical internal carotid artery (ICA) with intracranial LVO, may have technical EVT challenges and worse outcomes. We sought to compare treatments and outcomes for patients with anterior circulation tandem lesions versus isolated LVOs. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 26, 2020 Category: Neurology Authors: Neal M. Nolan, Robert W. Regenhardt, Matthew J. Koch, Scott B. Raymond, Christopher J. Stapleton, James D. Rabinov, Scott B. Silverman, Thabele M. Leslie-Mazwi, Aman B. Patel Source Type: research

Endovascular Therapy of Acute Ischemic Stroke in Patients with Large-Vessel Occlusion Associated with Active Malignancy
Approximately 15% of cancer patients have concomitant cerebrovascular disease.1,2 The frequency of ischemic and hemorrhagic stroke in this group of patients is similar to the general population2, and about one in ten stroke patients may have a concurrent malignancy.3 Intravenous thrombolysis (IVT) in these patients is often contraindicated and is used less frequently due to various possible comorbidities.4 While EVT is a well-established approach to treat acute ischemic stroke (AIS) secondary to large vessel occlusion (LVO) 5,6,7,8, there is paucity of data with regards to EVT success and outcomes in patients with active m...
Source: Journal of Stroke and Cerebrovascular Diseases - November 24, 2020 Category: Neurology Authors: Tomohiko Ozaki, Patrick Nicholson, Joanna D. Schaafsma, Ronit Agid, Timo Krings, Aleksandra Pikula, Vitor Mendes Pereira Source Type: research

CYP2C19 Loss-of-Function is Associated with Increased Risk of Ischemic Stroke after Transient Ischemic Attack in Intracranial Atherosclerotic Disease
Intracranial atherosclerotic disease (ICAD) is responsible for 8-10% of acute ischemic strokes, and resistance to antiplatelet therapy is prevalent. CYP2C19 gene loss-of-function (up to 45% of patients) causes clopidogrel resistance. For patients with asymptomatic ICAD and ICAD characterized by transient ischemic attack (TIA), this study measures the effect of CYP2C19 loss-of-function on ischemic stroke risk during clopidogrel therapy. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 24, 2020 Category: Neurology Authors: Pious D. Patel, Praveen Vimalathas, Xinnan Niu, Chevis N. Shannon, Joshua C. Denny, Josh F. Peterson, Rohan V. Chitale, Matthew R. Fusco Source Type: research

Stroke Knowledge in the EstEPA Project, a Population-Based Study
Stroke knowledge is poor in the general population worldwide. Yet, data from Spanish-Speaking populations, particularly in Latin America, are scant. We aim to evaluate stroke awareness using personal interviews in a population-based study. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 24, 2020 Category: Neurology Authors: Maximiliano A Hawkes, Maia M Gomez-Schneider, Daiana E Dossi, Mario O Melcon, Sebasti án F Ameriso Source Type: research

Emergency Medicine Physician Attitudes toward Anticoagulant Initiation for Patients with Atrial Fibrillation
Guidelines for the primary prevention of stroke recognize the emergency department as a location for physicians to identify atrial fibrillation and to initiate oral anticoagulants. Numerous studies have shown low anticoagulant prescription rates —approximately 18%—in OAC-naïve patients with atrial fibrillation discharged from the emergency department. We sought to obtain the opinions of Emergency Medicine physicians regarding anticoagulant decision-making for patients with atrial fibrillation seen in the emergency department. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 24, 2020 Category: Neurology Authors: Hope Hua, Nicole Sur, Lilly Lee, Seemant Chaturvedi Source Type: research

Serum Neuropeptide Y Level is Associated with Post-Ischemic Stroke Epilepsy
Background and purpose: Post-ischemic stroke epilepsy (PISE) is one of the common complications of stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 24, 2020 Category: Neurology Authors: Nuan Wang, Dongxing Wang, Hao Zhou, Cuifu Xu, Xiaowei Hu, Zhiyuan Qian, Xingshun Xu Source Type: research

Large Artery Atherosclerotic Clots are Larger than Clots of other Stroke Etiologies and have Poorer Recanalization rates
In this study, we measured the Extracted Clot Area (ECA) retrieved during endovascular treatment (EVT) and investigated relationships with suspected etiology, administration of intravenous thrombolysis and recanalization. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 24, 2020 Category: Neurology Authors: Se án Fitzgerald, Rosanna Rossi, Oana Madalina Mereuta, Sara Molina, Adaobi Okolo, Andrew Douglas, Duaa Jabrah, Abhay Pandit, Ray McCarthy, Michael Gilvarry, Erik Ceder, Niclas Dehlfors, Dennis Dunker, Annika Nordanstig, Petra Redfors, Katarina Jood, Geo Source Type: research

Effect of Sex on Clinical Outcome and Imaging after Endovascular Treatment of Large-Vessel Ischemic Stroke
In this study we assess the effect of sex on radiological and functional outcomes in EVT-treated acute stroke patients and determine if differences in baseline perfusion status between men and women might account for differences in outcomes. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 21, 2020 Category: Neurology Authors: Jelle Demeestere, S ören Christensen, Michael Mlynash, Christian Federau, Gregory W. Albers, Robin Lemmens, Maarten G. Lansberg Source Type: research

Diagnostic Accuracy of a Bedside Screening Tool for Dysphagia (BSTD) in Acute Stroke Patients
This study aimed at developing a user-friendly bedside examination to identify the risk of dysphagia in stroke patients at hospital admission. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 21, 2020 Category: Neurology Authors: Paolo Immovilli, Eugenia Rota, Nicola Morelli, Elena Marchesi, Chiara Terracciano, Domenica Zaino, Giampiero Ferrari, Roberto Antenucci, Donata Guidetti Source Type: research

T-Configuration Stent Placement for Carotid Bifurcation Stenosis Co-Existing with Ipsilateral Intracranial Stenosis: A Case Report and Literature Review
Carotid bifurcation stenosis is an important cause of ischemic stroke particularly in patients with intracranial artery stenosis.1 In such a condition, combined treatment with carotid artery stenting (CAS)/carotid endarterectomy (CEA) and extracranial-to-intracranial (EC-IC) bypass may be a useful option to prevent future ischemic stroke events.2-5 Adequate antegrade flow in the ipsilateral external carotid artery (ECA) is required in EC-IC bypass. However, conventional CAS/CEA occasionally results in ipsilateral ECA occlusion. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 21, 2020 Category: Neurology Authors: Yuki Kubota, Yoshiki Hanaoka, Jun-ichi Koyama, Yu Fujii, Toshihiro Ogiwara, Kiyoshi Ito, Tetsuyoshi Horiuchi Tags: Case Report Source Type: research

Association Between Small Vessel Disease Markers, Medial Temporal Lobe Atrophy and Cognitive Impairment After Stroke: A Systematic Review and Meta-Analysis
Two-thirds of stroke survivors suffer from cognitive impairment, and up to one-third of them progress to dementia. However, the underlying pathogenesis is complex and controversial. Recent evidence has found that cerebral small vessel disease (SVD) markers and the Alzheimer's disease (AD) neuroimaging marker medial temporal lobe atrophy (MTLA), alone or in combination, contribute to the pathogenesis of poststroke cognitive impairment (PSCI). In the present systematic review and meta-analysis, we synthesized proof for these neuroimaging risk factors among stroke patients. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 20, 2020 Category: Neurology Authors: Furu Wang, Sunyu Hua, Yue Zhang, Hongchang Yu, Zhongshuai Zhang, Jiangtao Zhu, Rong Liu, Zhen Jiang Source Type: research

Masthead
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 19, 2020 Category: Neurology Source Type: research

Editorial Board
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 19, 2020 Category: Neurology Source Type: research

Table of Contents
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 19, 2020 Category: Neurology Source Type: research

The Association Between Apolipoprotein E Gene Polymorphism and In-Stent Restenosis After Extracranial and Intracranial Artery Stenting
Stroke is one of the leading causes of disability and death worldwide. In China acute ischemic stroke (AIS) accounts for approximately 70% of all strokes. As an important cause of AIS, large artery atherosclerotic stroke (LAAS) is characterized by high morbidity, disability rate, recurrence rate and mortality.1 –3 The safety and efficacy of stenting in preventing recurrence of stroke have been demonstrated;4,5 however, in-stent restenosis (ISR) remains a major limitation of endovascular treatment. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 19, 2020 Category: Neurology Authors: Zhoucheng Kang, Yuhong Cao, Li Li, Guangyun Zhang Source Type: research

Understanding and informing community emergency cardiovascular disease preparedness during the COVID-19 pandemic: Stroke Ready
Acute stroke and acute myocardial infarction (AMI) treatments are time sensitive. Early data revealed a decrease in presentation and an increase in pre-hospital delay for acute stroke and AMI during the coronavirus disease 2019 (COVID-19) pandemic. Thus, we set out to understand community members ’ perception of seeking acute stroke and AMI care during the COVID-19 pandemic to inform strategies to increase cardiovascular disease preparedness during the pandemic. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 18, 2020 Category: Neurology Authors: Maria Cielito Robles, Casey L. Corches, Morgan Bradford, Tia S. Rice, Devraj Sukul, Mellanie V. Springer, Sarah Bailey, Alina Oliver, Lesli E. Skolarus Source Type: research

Reducing the Risk of Stroke in Patients with Impaired Renal Function: Nutritional Issues
Patients with renal failure have extremely high cardiovascular risk; in dialysis patients the risk of stroke is increased approximately 10-fold over that in the general population. Reasons include not only a high prevalence of traditional risk factors such as diabetes, hypertension and dyslipidemia, but also the accumulation of toxic substances that are eliminated by the kidneys, so have very high levels in patients with renal failure. These include plasma total homocysteine, asymmetric dimethylarginine, thiocyanate, and toxic products of the intestinal microbiome (Gut-Derived Uremic Toxins; GDUT), which include trimethyla...
Source: Journal of Stroke and Cerebrovascular Diseases - November 17, 2020 Category: Neurology Authors: J. David Spence Tags: Review Article Source Type: research

Stroke Awareness among Elderly Hypertensives in a Rural Area of Bangalore District, India
India faces a high and growing burden of hypertension, which is an important cerebrovascular risk factor, especially in elderly persons. Poor awareness contributes to delays in seeking health care, which is undesirable given the emergent nature of stroke. Literature regarding awareness in this subgroup of the population is scarce. Our objective was to assess awareness regarding cerebrovascular disease among elderly persons with hypertension residing in a rural area of Bangalore district, and estimate their individual risk of stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 15, 2020 Category: Neurology Authors: Vivek Bhat, Thanmayi GS, Arvind Kasthuri Source Type: research

Prognosis of Neurological Improvement in Inpatient Acute Ischemic Stroke Survivors: A Propensity Score Matching Analysis
Stroke has become a national concern in China. Early prediction of stroke benefits patients and aids medical professionals in clinical decision making and rehabilitation plans to improve successful outcomes. To identify prediction factors influencing short-term outcomes in patients with acute ischemic stroke (AIS). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 14, 2020 Category: Neurology Authors: Qian Wu, Ai-Jie Tang, Li Zeng, Shu-Zhen Niu, Mei-Mei Tian, Ai-Ping Jin, Hong-Yan Yang, Jing-Juan Chen, Zhu Xiao-ping, Yan Shi Source Type: research

Risk Factors of Post-Stroke Epilepsy in Children; Experience from a Tertiary Center and a Brief Review of the Literature
Arterial ischemic stroke (AII) is a significant cause of acute seizures, and survivors frequently develop post-stroke epilepsy (PSE).1 The frequency of PSE has been widely studied in adults. Post-stroke seizures have been reported in 5 –20% of elderly individuals, whereas the development of epilepsy is rare and ranges from 2% to 15%.2–4 Few studies have investigated risk factors for PSE in children. Due to variations in study population characteristics, sample size, and age range, PSE frequencies vary in children. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 13, 2020 Category: Neurology Authors: İpek Polat, Uluç Yiş, Müge Ayanoğlu, Derya Okur, Pınar Edem, Cem Paketçi, Erhan Bayram, Semra Hız Kurul Source Type: research

Validity and Reliability of The 3-Meter Backward Walk Test in Individuals with Stroke
The 3-m backward walk test (3MBWT) is used to evaluate neuromuscular control, proprioception, protective reflexes, fall risk and balance. The aim of our study was to reveal the test-retest reliability and validity of the 3MBWT in stroke patients. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 13, 2020 Category: Neurology Authors: Ay şe Abit Kocaman, Saniye Aydoğan Arslan, Kübra Uğurlu, Zekiye İpek Katırcı Kırmacı, E.Dilek Keskin Source Type: research

Increasing Blood Pressure Variability Predicts Poor Functional Outcome Following Acute Stroke
Increasing blood pressure variability has been reported following acute stroke, but there is uncertainty about how best to measure it and about the impact on prognosis following acute ischaemic stroke and transient ischaemic attack. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 13, 2020 Category: Neurology Authors: Karen OB Appiah, Mintu Nath, Lisa Manning, William J Davison, Sara Mazzucco, Linxin Li, F Potter John, Peter M Rothwell, Ronney B Panerai, Victoria J Haunton, Thompson G Robinson Source Type: research

Renal-Cerebral Pathophysiology: The Interplay Between Chronic Kidney Disease and Cerebrovascular Disease
Cerebrovascular disease has increasingly been linked to overall vascular health. Pathologic conditions like diabetes, hypertension, and kidney disease have been shown to affect brain health and cerebrovascular and nervous systems. Acute kidney injury (AKI) and chronic Kidney Disease (CKD) represent a variety of vascular insults that can adversely affect cerebral health. Hypertension, fluctuations in blood pressure, and diabetic vasculopathy are known risk factors for cerebrovascular disease associated with CKD. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 13, 2020 Category: Neurology Authors: Ramy M Hanna, Antoney Ferrey, Connie M Rhee, Kamyar Kalantar-Zadeh Source Type: research

Development of Internal Carotid Artery Dissection During Masturbation
Sexual intercourse is known as one of the daily activities triggering spontaneous cervicocephalic artery dissection (sCAD), however, it has been unclear if masturbation can trigger the development of sCAD. Herein, we report a case of sCAD in association with masturbation. A 51-year-old right-handed man developed subarachnoid hemorrhage during masturbation. The dissection of the left internal carotid artery was evident on the 9th hospital day. Finally, he was treated with stenting and coiling and discharged with a good prognosis. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 11, 2020 Category: Neurology Authors: Masahiro Oomura, Takumi Kitamura, Kenichi Adachi, Yusuke Nishikawa, Mitsuhito Mase Tags: Case Report Source Type: research

Integrity of The Hand Fibers of The Corticospinal Tract Shown by Diffusion Tensor Imaging Predicts Hand Function Recovery After Hemorrhagic Stroke
Hemorrhagic stroke often results in motor dysfunction. One of the treatment goals for stroke is the recovery of motor function, especially the hand function, which is critical for daily life.1 It has been suggested that damage to neural pathways is a critical factor for the prognosis of stroke.2,3 The corticospinal tract (CST) is an important neural pathway through which the cerebral cortex controls limb movement. In patients with hemorrhagic stroke, lesions to the CST are the primary reason of motor dysfunction. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 11, 2020 Category: Neurology Authors: Zhigang Gong, Rongjun Zhang, Wenbin Jiang, Zhihui Fu Source Type: research

Coffee Consumption and Stroke Risk: Evidence from a Systematic Review and Meta-Analysis of more than 2.4 Million Men and Women
Stroke remains the leading cause of disability and mortality globally. Based on the Global Burden of Disease Study 2016, it was estimated that there were 13.7 million new stroke cases, 5.5 million deaths, 80.1 million prevalent cases, and 116.4 million disability-adjusted life-years.1 About 75% of stroke cases are ischemic, whereas the remaining cases are hemorrhagic.2 Stroke incidence increases with age. Well-known risk factors for stroke include personal history of hypertension, diabetes and cardiac diseases, unhealthy behavioral factors (heavy cigarette consumption, less physical inactivity, poor diet), and serious envi...
Source: Journal of Stroke and Cerebrovascular Diseases - November 11, 2020 Category: Neurology Authors: Chuan Shao, Hui Tang, Xiaoya Wang, Jiaquan He Source Type: research

Hemoglobin Improvement is Positively Associated with Functional Outcomes in Stroke Patients with Anemia
Anemia is a prevalent concern in geriatric medicine. Previous studies have highlighted the high prevalence and adverse healthcare outcomes of anemia in older adults.1,2 Anemia, defined by the World Health Organization (WHO) as a hemoglobin level below 12 and 13 g/dL in women and men, respectively,3 is common in older adults, and an estimated 13% of older adults over age 70 are anemic.1,4 Moreover, anemia has been associated with poor physical performance and disability, frailty, decreased quality of life, and increased mortality rate in community-dwelling older adults. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 11, 2020 Category: Neurology Authors: Yoshihiro Yoshimura, Hidetaka Wakabayashi, Ai Shiraishi, Fumihiko Nagano, Takahiro Bise, Sayuri Shimazu Source Type: research

Repeated Endovascular Thrombectomy in Patients with Acute Ischemic Stroke in a Single Center
Patients with acute ischemic stroke treated with endovascular thrombectomy may be treated with repeat endovascular thrombectomy (rEVT) in case of recurrent large vessel occlusion (LVO). The purpose of this study is to report the frequency, timing, and outcomes of rEVT in a single center. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 11, 2020 Category: Neurology Authors: Hyun Jin Lee, Hyo Sung Kwak, Gyung Ho Chung, Jung-Soo Park Source Type: research

Reply to Letter to Editor
We sincerely thank Dr. Varun and colleagues for showing interest in our article, “The outcome of Medical Management of Chronic Subdural Hematoma,” published online recently. The comments are welcome, and we have gone through them in detail. We provide the following explanation to the concerns raised by them. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 11, 2020 Category: Neurology Authors: Raja.K. Kutty Source Type: research

A Rare Case of Capgras Syndrome in Moyamoya Disease
We report the case of a 51-year-old woman with frontal lobe ischemic stroke caused by moyamoya disease, presenting with Capgras syndrome. Dysfunction of frontal areas may be attributable to development of Capgras syndrome. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 7, 2020 Category: Neurology Authors: Kazuma Koda, Yoshihisa Otsuka, Yukihiro Yoneda, Ryo Tsukamoto, Yasufumi Kageyama Tags: Case Report Source Type: research

Tranexamic Acid Inhibits Hematoma Expansion in Intracerebral Hemorrhage and Traumatic Brain Injury. Does Blood Pressure Play a Potential Role? A Meta-Analysis from Randmized Controlled Trials
Tranexamic acid (TXA) is an antifibrinolytic agent, which has shown an effect on reducing blood loss in many diseases. Many studies focus on the effect of TXA on cerebral hemorrhage, however, whether TXA can inhibit hematoma expansion is still controversial. Our meta-analysis performed a quantitative analysis to evaluate the efficacy of TXA for the hematoma expansion in spontaneous and traumatic intracranial hematoma. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 7, 2020 Category: Neurology Authors: Bixi Gao, Tao Xue, Xiaoci Rong, Yanbo Yang, Zilan Wang, Zhouqing Chen, Zhong Wang Source Type: research

Preoperatively estimated graft flow rate contributes to the improvement of hemodynamics in revascularization for Moyamoya disease
Moyamoya disease is a cerebrovascular disease that is characterized by chronic progressive stenosis of the terminal portion of the internal carotid artery (ICA) on both sides of the brain, which results in an abnormal vascular network of the collateral pathways at the base of the brain.1,2 Therefore, patients with Moyamoya disease have a decreased cerebral blood flow (CBF) and reduced cerebral perfusion pressure,3 which can result in ischemic and/or hemorrhagic stroke. This hemodynamic condition can be evaluated using positron emission tomography (PET) or single-photon emission computed tomography (SPECT) as the gold stand...
Source: Journal of Stroke and Cerebrovascular Diseases - November 7, 2020 Category: Neurology Authors: Tomoyoshi Kuribara, Takeshi Mikami, Katsuya Komatsu, Yusuke Kimura, Sangnyon Kim, Kei Miyata, Yukinori Akiyama, Rei Enatsu, Toru Hirano, Nobuhiro Mikuni Source Type: research

Acute Blood Pressure and Outcome After Intracerebral Hemorrhage: The VISTA-ICH Cohort
Recent clinical trials suggest that it is safe to acutely lower systolic blood pressure (BP) to 140  mm Hg after ICH, but uncertainty remains regarding optimal management. We sought to better define the link between BP and outcome in ICH patients using data from the Virtual International Stroke Trials Archive (VISTA). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 7, 2020 Category: Neurology Authors: Charles L Francoeur, Stephan A Mayer, VISTA-ICH Collaborators Source Type: research

The Effect of Hyperglycemia on Infarct Growth after Reperfusion: An Analysis of the DEFUSE 3 trial
Brain infarct growth, despite successful reperfusion, decreases the likelihood of good functional outcome after ischemic stroke. In patients undergoing reperfusion, admission glucose is associated with poor outcome but the effect of glucose level on infarct growth is not well studied. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 6, 2020 Category: Neurology Authors: Shadi Yaghi, Seena Dehkharghani, Eytan Raz, Mahesh Jayaraman, Omar Tanweer, Brian Mac Grory, Nils Henninger, Maarten G. Lansberg, Gregory W. Albers, Adam de Havenon Source Type: research

Endovascular Treatment of Symptomatic Intracranial Vertebrobasilar Stenosis: A 10-Year Single Centre Experience Using Balloon-Expandable Coronary Artery Stents
Few experiences on vertebro-basilar cerebro-vascular diseases has been reported in literature compared to anterior circulation.1 This is probably due to the lower diagnostic power in the posterior fossa before the MRI-era and the lack of treatment options in the past.2 Transient ischemic attacks (TIAs) and ischemic strokes of the posterior circulation account for about a fifth of all cerebro-vascular accidents,3 but often result in worse morbidity and mortality compared to anterior circulation strokes. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 6, 2020 Category: Neurology Authors: Mariangela Piano, Luca Milonia, Amedeo Cervo, Beatrice Modello, Antonio Macera, Guglielmo Pero, Luca Quilici, Edoardo Boccardi, Luca Valvassori Source Type: research

Factors Influencing Sitting Ability During the Acute Post-Stroke Phase: A Multicenter Prospective Cohort Study in Japan
Stroke is the second leading cause of both death and disability worldwide.1 In Japan, stroke is the fourth leading cause of death2 and the second leading cause of being bedridden3 due to residual neurological and neuropsychological disorders. Long-term prognoses for stroke patients can be improved through acute stroke rehabilitation.4 Therefore, appropriate rehabilitation and mobilization at an early stage are necessary to improve functional prognoses after stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 6, 2020 Category: Neurology Authors: Kazuhiro Fukata, Yuji Fujino, Masahide Inoue, Mamiko Inoue, Daisuke Sekine, Misato Tsutsumi, Tetsuya Okihara, Masayuki Mano, Hiroshi Miki, Hirofumi Sato, Yohei Kobayashi, Koki Hasegawa, Yota Kunieda, Shunichi Ishihara, Shigeru Makita, Hidetoshi Takahashi, Source Type: research

Cerebral Venous Sinus Thrombosis In COVID-19 Infection: A Case Series and Review of the Literature
SARS-CoV-2, the virus responsible for novel Coronavirus (COVID-19) infection, has recently been associated with a myriad of hematologic derangements; in particular, an unusually high incidence of venous thromboembolism has been reported in patients with COVID-19 infection. It is postulated that either the cytokine storm induced by the viral infection or endothelial damage caused by viral binding to the ACE-2 receptor may activate a cascade leading to a hypercoaguable state. Although pulmonary embolism and deep venous thrombosis have been well described in patients with COVID-19 infection, there is a paucity of literature o...
Source: Journal of Stroke and Cerebrovascular Diseases - November 6, 2020 Category: Neurology Authors: Katarina Dakay, Jared Cooper, Jessica Bloomfield, Philip Overby, Stephan A. Mayer, Rolla Nuoman, Ramandeep Sahni, Edwin Gulko, Gurmeen Kaur, Justin Santarelli, Chirag D. Gandhi, Fawaz Al-Mufti Tags: Case Report Source Type: research

COVID-19 Respiratory Illness and Subsequent Cerebrovascular Events, the Initial Iranian Experience
Coronavirus disease 2019 (COVID-19) infection has rapidly spread across the world, currently affecting more than 39 million people, leading to major societal, economical and health care system distruptions.1 Older adults and those with vascular co-morbidities are disproportionately affected.2,3 More than one third of patients who required intensive care unit admission had at least one underlying vascular risk factor.4 In addition to respiratory symptoms, COVID-19 infection can also lead to hematological and cardiac complications. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 6, 2020 Category: Neurology Authors: Behnam Sabayan, Mohsen Moghadami, Farhad Assarzadegan, Sahar Hojjat-Anasri Komachali, Leila Poordast, Zabihollah Babaeepour, Seyed Amir Ebrahimzadeh, Ava Hamidi, Zeinab Hasheminejad, Elahe Mohammadi-Vosough, Hamid Reza Mirkarimi, Sepideh Paybast, Nasrin R Source Type: research

Individualized Perioperative Blood Pressure Management for Adult Moyamoya Disease: Experience from 186 Consecutive Procedures
In adult patients with moyamoya disease (MMD) underwent combined revascularization, cerebral infarction during the acute postoperative phase is common and can lead to neurological dysfunction after revascularization in MMD patients. The aim of this study was to share the experience of individualized perioperative blood pressure (BP) management for adult MMD patients in one single center. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 5, 2020 Category: Neurology Authors: Changwen Li, Nan Zhang, Shaojie Yu, Yong Xu, Yang Yao, Minghui Zeng, Dongxue Li, Chengyu Xia Source Type: research

Predictors of Clopidogrel Hyper-Responsiveness in Neuro-Interventional Procedures
Hyper-responsiveness to clopidogrel abnormally inhibits platelet aggregation and increases hemorrhagic complications. The present study investigated clinical factors related to clopidogrel hyper-responsiveness in neuro-interventional procedures. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 5, 2020 Category: Neurology Authors: Ryotaro Suzuki, Masaya Nagaishi, Issei Takano, Tomoji Takigawa, Akio Hyodo, Kensuke Suzuki Source Type: research

Assessing Self-Reported Mood in Aphasia Following Stroke: Challenges, Innovations and Future Directions
Assessment of mood is critical in determining rehabilitation outcomes for stroke and other acquired brain injury, yet a common consequence of such injuries is aphasia, where language is impaired. Consequently, the use of language-based measures in this population is often not possible. Following a critical review of the neuropsychological aspects of self-reported mood, this paper evaluates the problems in reporting mood after stroke due to aphasia, and discusses implications for the design of adapted instruments. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 5, 2020 Category: Neurology Authors: Paul D. Barrows, Shirley A. Thomas, William Van Gordon Source Type: research

Factors Associated with Delay of Emergency Medical Services Activation in Patients with Acute Stroke
The poor prognosis of acute stroke may be largely attributed to delays in treatment. Emergency medical services (EMS) usage is associated with a significant reduction in the delay in stroke treatment. The aims of this study were to identify factors associated with the delay in EMS activation for patients with acute stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 5, 2020 Category: Neurology Authors: Ah Ram Seo, Hwan Song, Woon Jeong Lee, Kyu Nam Park, Jundong Moon, Daehee Kim Source Type: research

Pro B-type Natriuretic Peptide and Midregional Proadrenomedullin are Associated with Incident Carotid Stenosis During Long Term Follow-up
Background: Plasma biomarkers may be useful to detect healthy individuals at increased risk for atherosclerotic manifestations, such as carotid artery stenosis. The aim of this longitudinal cohort study was to evaluate new biomarkers in relation to C-reactive protein and conventional risk factors for carotid artery stenosis during long term follow-up (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 4, 2020 Category: Neurology Authors: Shahab Fatemi, Stefan Acosta, Moncef Zarrouk, Gunnar Engstr öm, Olle Melander, Anders Gottsäter Source Type: research

Knowledge of Acute Stroke Management Among Healthcare Professionals: Development and Validation of Acute Stroke Management Questionnaire (ASMaQ)
Around 15.0% of all strokes occurred in hospitalised patients and studies showed significant delay in the stroke recognition and lack of awareness on thrombolytic therapy for acute ischaemic stroke (AIS) which lead to higher mortality for in-hospital stroke. We aimed to develop and validate a new instrument known as acute stroke management questionnaire (ASMaQ) to evaluate the awareness of healthcare professionals in managing acute ischaemic stroke cases. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 4, 2020 Category: Neurology Authors: Chun yang Sim, Wan Asyraf Wan Zaidi, Shamsul Azhar Shah, Wan Nur Nafisah Wan Yahya, Hui jan Tan Source Type: research

Bilateral MCP Infarct Due to Vertebral Giant Cell Arteritis
We present the case of an 83-year-old woman with an isolated bilateral middle cerebellar peduncles stroke caused by complete occlusion of the right vertebral artery and focal occlusion of the left vertebral artery due to giant cell arteritis. The diagnosis was achieved by integrating MRI, ultrasound study, laboratory data and subsequent pathology analysis after biopsy of the temporal artery. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 4, 2020 Category: Neurology Authors: Gennaro Castiello, Carlo A. Mallio, Claudia Altamura, Massimo Marano, Anna Crescenzi, Bruno Beomonte Zobel, Carlo C. Quattrocchi, Vincenzo Di Lazzaro Tags: Case Report Source Type: research

Improving Acute In-Hospital Stroke Care by Reorganization of an In-Hospital Stroke Code Protocol
Delays in recognition and assessment of in-hospital strokes (IHS) can lead to poor outcomes. The aim was to examine whether reorganized IHS code protocol can reduce treatment time. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 4, 2020 Category: Neurology Authors: Hiroyuki Kawano, Shiori Ebisawa, Mizuki Ayano, Yuko Kono, Mikito Saito, Takashi Johno, Hibiku Maruoka, Nakada Ryoji, Hitomi Yamashita, Kaoru Nakanishi, Yuko Honda, Tatsuo Amano, Yoshiko Unno, Yuka Komatsu, Yuriko Ogawa, Yoshiaki Shiokawa, Teruyuki Hirano Source Type: research

Stroke and Chronic Kidney Disease in Fabry Disease
Fabry disease is an X-linked lysosomal storage disorder caused by pathogenic variants in the GLA gene leading to a deficiency of the enzyme alpha-galactosidase A ( α-Gal A). Multiple organ systems are implicated in Fabry disease, most severely the cardiac, kidney, and central nervous systems. In this brief review, we will focus on the kidney and central nervous system involvement. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 4, 2020 Category: Neurology Authors: Daisy Tapia, Virginia Kimonis Source Type: research

The impact of Covid-19 lockdown on stroke admissions and treatments in Campania
This study analyses the impact of Covid-19 pandemic and lockdown measures on the incidence of stroke, in Campania, the most densely-populated region in Italy.Methods: we retrospectively analysed data regarding acute stroke patients presenting at 5 Campania stroke hubs, before and after the issue of lockdown in Italy on March 9th, 2020. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 4, 2020 Category: Neurology Authors: Candelaresi Paolo, Manzo Valentino, Giovanna Servillo, Muto Mario, Barone Paolo, Napoletano Rosa, Saponiero Renato, Andreone Vincenzo, Palma Vincenzo, Spitaleri Daniele, D'Onofrio Florindo, Maniscalco Giorgia, Salvatore Simona, Leone Giuseppe, Capone Elis Source Type: research