Tamibarotene Improves Hippocampus Injury Induced by Focal Cerebral Ischemia-Reperfusion via Modulating PI3K/Akt Pathway in Rats
Goal: The present study aimed to examine whether Am80 (tamibarotene) protects the hippocampus against cerebral ischemia-reperfusion (I/R) injury and whether phosphoinositide-3-kinase/Akt (PI3K/Akt) pathway mediates this effect. Materials and methods: Rats were subjected to 90 minutes of middle cerebral artery occlusion followed by 24 hours of reperfusion. The animals were randomly divided into 7 groups: sham-operated group; I/R group; groups pretreated with 2 mg/kg, 6 mg/kg, and 10 mg/kg of Am80; Am80 (6 mg/kg) combined with the selective PI3K inhibitor wortmannin (0.6 mg/kg), and wortmannin (0.6 mg/kg) only group. (Source...
Source: Journal of Stroke and Cerebrovascular Diseases - May 8, 2019 Category: Neurology Authors: Xiaocui Tian, Ruidi An, Yujie Luo, Minghang Li, Lu Xu, Zhi Dong Source Type: research

Reproducibility of 3.0T High-Resolution Magnetic Resonance Imaging for the Identification and Quantification of Middle Cerebral Arterial Atherosclerotic Plaques
Objective: To assess the reproducibility of 3.0T high-resolution magnetic resonance imaging for the identification and quantification of atherosclerotic plaques in the middle cerebral artery. Methods: Sixty-nine consecutive patients with ischemic stroke or asymptomatic stenosis (>30%) of the middle cerebral artery underwent 3.0T high-resolution magnetic resonance imaging examinations. Two independent investigators reviewed all images with 1 investigator re-evaluating all images 4 weeks later. Wall characteristics of the middle cerebral artery, including plaque surface morphology, plaque location, plaque components, and ...
Source: Journal of Stroke and Cerebrovascular Diseases - May 8, 2019 Category: Neurology Authors: Deng-Ling Zhao, Cheng Li, Xiao-Hui Chen, Shenghong Ju, Gang Deng, Bo Xie, Gao-Jun Teng Source Type: research

A Dose-Response Relationship Between Sleep Duration and Stroke According to Nonhealth Status in Central China: A Population-based Epidemiology Survey
Purpose: The aim was to investigate the relationship between sleep duration and stroke according to nonhealth status among adults in Central China. Methods: A total of 18,670 participants were selected by stratified multistage random sampling method in Henan province during 2013-2015. Restricted cubic splines and logistic regression were used to calculate the association between sleep duration and stroke. Results: Sleep duration showing a J-shaped dose-response association with risk of stroke among the Chinese adults in the study. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - May 7, 2019 Category: Neurology Authors: Qiaoyun Guo, Weihong Xie, Rui Peng, Yan Ma, Feifei Chong, Yanli Wang, Mengmeng Song, Hua Ye, Peng Wang, Kaijuan Wang, Chunhua Song Source Type: research

Neutrophil-to-Lymphocyte Ratio and Response to Intravenous Thrombolysis in Patients with Acute Ischemic Stroke
Background and Aims: The Neutrophil-to-Lymphocyte Ratio (NLR) is suggested as a readily available and inexpensive biomarker to predict prognosis of acute stroke. Experience with intravenous (IV) tissue plasminogen activator (tPA) treatment is limited. Methods: Total 142 (80 female, age: 69 ± 13 yearr) consecutive acute stroke patients treated with IV tPA were evaluated. Admission and 24th hour lymphocyte, neutrophil, and monocyte counts were measured and the NLR was calculated. Results: Average NLR elevated (by 3.47 ± 6.75) significantly from admission to 24th hour (P (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - May 6, 2019 Category: Neurology Authors: M. Yasir Pektezel, Ezgi Yilmaz, E. Murat Arsava, M. Akif Topcuoglu Source Type: research

Association of CYP3A4*1G and CYP3A5*3 With the 1-year Outcome of Acute Ischemic Stroke in the Han Chinese Population
Background and purpose: Previous studies have shown that common variants within CYP3A4 and CYP3A5 are associated with statin pharmacokinetics and the risk of cardiovascular disease. However, the association of variants in CYP3A4 and CYP3A5 with the prognosis of ischemic stroke remains undetermined. Therefore, we investigated this herein. Methods: Four hundred thirty-three consecutive patients with acute ischemic stroke were recruited. The outcome at the 1-year follow-up was assessed using the modified Rankin Scale (mRS). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - May 4, 2019 Category: Neurology Authors: Shuo Li, Chang-he Shi, Xin-jing Liu, Yu-sheng Li, Shao-hua Li, Bo Song, Yu-ming Xu Source Type: research

Serum Glucose and Potassium Ratio as Risk Factors for Cerebral Vasospasm after Aneurysmal Subarachnoid Hemorrhage
Objective: Cerebral vasospasm is associated with poor prognosis in patients with aneurysmal subarachnoid hemorrhage (SAH), and biomarkers for predicting poor prognosis have not yet been established. We attempted to clarify the relationship between serum glucose/potassium ratio and cerebral vasospasm in patients with aneurysmal SAH. Methods: We studied 333 of 535 aneurysmal SAH patients treated between 2006 and 2016 (123 males, 210 females; mean age 59.7 years; range 24-93). We retrospectively analyzed the relationship between cerebral vasospasm grade and clinical risk factors, including serum glucose/potassium ratio. (Sour...
Source: Journal of Stroke and Cerebrovascular Diseases - May 3, 2019 Category: Neurology Authors: Fumihiro Matano, Yu Fujiki, Takayuki Mizunari, Kenta Koketsu, Tomonori Tamaki, Yasuo Murai, Hiroyuki Yokota, Akio Morita Source Type: research

Combination of Exoskeletal Upper Limb Robot and Occupational Therapy Improve Activities of Daily Living Function in Acute Stroke Patients
Purpose: Previous studies have suggested that upper limb rehabilitation using therapeutic robots improves motor function of stroke patients. However, the effect of upper limb robotic rehabilitation on improving functioning in activities of daily living (ADL) remains unclear. The present study aimed to determine whether upper limb rehabilitation using single joint Hybrid Assistive Limb (HAL-SJ) affects ADL function and the use of a hemiparetic arm in ADLs of acute stroke patients. Materials and Methods: Twelve acute stroke patients participated in the study and were randomly divided into group A or group B. (Source: Journal...
Source: Journal of Stroke and Cerebrovascular Diseases - April 30, 2019 Category: Neurology Authors: Yuji Iwamoto, Takeshi Imura, Takahiro Suzukawa, Hiroki Fukuyama, Takayuki Ishii, Shingo Taki, Naoki Imada, Masaaki Shibukawa, Tetsuji Inagawa, Hayato Araki, Osamu Araki Source Type: research

Balloon-like Mobile Plaque in the Innominate Artery: Ultrasonographic and Pathological Perspectives of Repetitive Embolism
Mobile plaque in the innominate artery is extremely rare and difficult to diagnose, especially in its acute stage. Its diagnosis is often delayed in many cases, resulting in delayed treatment and poor prognosis. Herein, we report the case of a 69-year-old patient with multiple cerebral infarction only in the right internal carotid artery and vertebrobasilar territories. No embolic sources were found until arterial ultrasonography detected a large balloon-like mobile plaque in the IA. Mobile plaque consisted of high-and low-echoic components and showed balloon-like plaque. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 30, 2019 Category: Neurology Authors: Hajime Ikenouchi, Kazuo Washida, Takeshi Yoshimoto, Kazuki Fukuma, Satoshi Saito, Yosuke Inoue, Hitoshi Matsuda, Masafumi Ihara Tags: Case Report Source Type: research

Renal Safety of Intra-Arterial Treatment after Acute Ischemic Stroke with Multimodal CT Imaging selection
Background: Multimodal computed tomography imaging is used to identify eligible patients for intra-arterial treatment. A concern with this method is the multiple use of iodinated contrast material which presents a possible risk of renal toxicity. We compared the safety of intra-arterial treatment versus intravenous treatment during acute ischemic stroke treatment with a focus on renal safety. Methods: Adult acute ischemic stroke patients who underwent a baseline Multimodal computed tomography, then intra-arterial treatment and/or intravenous treatment were identified. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 29, 2019 Category: Neurology Authors: Zicheng Hu, Tingting Shang, Rongzhong Huang, Qi Li, Peng Zheng, Haiyang Wang, Peng Xie Source Type: research

Preceding Antithrombotic Treatment is Associated With Acute Ischemic Stroke Severity and Functional Outcome at 90 Days Among Patients With Atrial Fibrillation
Antithrombotic therapies are known to prevent ischemic stroke (IS) for patients with atrial fibrillation (AF), but are often underused in clinical practice. The aim of present study was to investigate the prevalence of patients with acute IS with known history of AF who were not receiving antithrombotic treatment before stroke and to evaluate the association of preceding antithrombotic treatment with stroke severity and outcomes at 90 days after admission. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 29, 2019 Category: Neurology Authors: Xingyang Yi, Jing Lin, Zhao Han, Hua Luo, Minjie Shao, Daofeng Fan, Qiang Zhou Source Type: research

Akinetopsia on Driving
Akinetopsia is a quite rare symptom. Two types of akinetopsia have been reported: one is cinematographic vision, and the other is invisibility of moving objects. These symptoms are thought to occur due to dysfunction of the MT/V5 area at the occipitoparietal region. I herein describe a 54-year-old man who collided with a car parked on the left side of the road while driving. He complained that the parked car looked to be moving forwards and he could not stop his car when he noticed that it was parked. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 26, 2019 Category: Neurology Authors: Kengo Maeda Tags: Case Report Source Type: research

Absence of Collaterals is Associated with Larger Infarct Volume and Worse Outcome in Patients with Large Vessel Occlusion and Mild Symptoms
In this study, we aim to assess the use of collateral score to identify patients with LVO and mild symptoms that might benefit from mechanical thrombectomy (MT). Methods: A retrospective review of prospectively collected data on patients presenting with mild ischemic stroke (National Institute of Health Stroke Scale [NIHSS] (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 26, 2019 Category: Neurology Authors: Eric R. Kimmel, Sami Al Kasab, Jillian B. Harvey, Girish Bathla, Santiago Ortega-Gutierrez, Gabor Toth, Emily M. Jaksich, Ali Sheharyar, Jorge Roa, David M. Hasan, Edgar A. Samaniego Source Type: research

Embolic Stroke of Undetermined Source: A Population with Left Atrial Dysfunction
In this study, we tested the hypothesis that left atrial (LA) shape and function at rest, as well as with exercise, are abnormal compared to matched normal controls. Methods: The study design was prospective enrollment of ESUS subjects who underwent measurement of LA function at rest and exercise by 2D and 3D echocardiograms. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 26, 2019 Category: Neurology Authors: Karl Meisel, Kristy Yuan, Qizhi Fang, Dwight Bibby, Randall Lee, Nelson B. Schiller Source Type: research

Effects of Virtual Reality Compared to Conventional Therapy on Balance Poststroke: A Systematic Review and Meta-Analysis
The objective of this study was to systematically review the effect of virtual reality on balance as compared to conventional therapy alone poststroke. Methods: The databases of PubMed, Cochrane, and Ovid were searched using select keywords. The randomized controlled trials published between January 2000 and August 2017 in English language were included if they assessed the effect of virtual reality on balance ability compared to conventional therapy alone in adults ’ poststroke. The Physiotherapy Evidence Database scale was used to assess the methodological quality. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 25, 2019 Category: Neurology Authors: Roghayeh Mohammadi, Alireza Vaezpour Semnani, Majid Mirmohammadkhani, Namrata Grampurohit Tags: Review Article Source Type: research

Correlation of Objective Pupillometry to Midline Shift in Acute Stroke Patients
Background: Pupillary dysfunction is recognized as a sign of acute neurological deterioration due to worsening mass effect in patients with hemispheric strokes. Recent neuroimaging studies suggest that horizontal displacement of brain structures may be more important than vertical displacement in explaining these pupillary findings. Pupillometers allow objective and standardized evaluation of the pupillary light reflex. We hypothesized that pupillary data (Neurological Pupil index [NPi] and constriction velocity [CV]) obtained with a hand-held pupilometer, correlate with horizontal intracranial midline shift in patients wi...
Source: Journal of Stroke and Cerebrovascular Diseases - April 25, 2019 Category: Neurology Authors: Mohamed Osman, Sonja E. Stutzman, Folefac Atem, DaiWai Olson, Amber D. Hicks, Stefany Ortega-Perez, Salah G. Aoun, Ahmed Salem, Venkatesh Aiyagari Source Type: research

Factors Associated with Leukoaraiosis Severity in Acute Stroke Patients
Objective: Age-related cerebral white matter abnormalities, commonly termed leukoaraiosis (LA), are frequent manifestation of cerebral microvascular disease. Aging and hypertension are well linked to LA. We compared additional vascular risk factors and socioeconomic factors with LA severity in acute stroke patients. Methods: We analyzed 271 patients with acute ischemic or hemorrhagic stroke from a hospital registry. We collected clinical and socioeconomic data prospectively with a standardized questionnaire during acute stroke hospitalization. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 25, 2019 Category: Neurology Authors: Kishore Vedala, Arun K. Nagabandi, Stephen Looney, Askiel Bruno Source Type: research

Clinical and Pathological Benefit of Twendee X in Alzheimer's Disease Transgenic Mice with Chronic Cerebral Hypoperfusion
Multiple pathogeneses are involved in Alzheimer's disease (AD), such as amyloid- β accumulation, neuroinflammation, and oxidative stress. The pathological impact of chronic cerebral hypoperfusion on Alzheimer's disease is still poorly understood. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 24, 2019 Category: Neurology Authors: Xia Liu, Toru Yamashita, Jingwei Shang, Xiaowen Shi, Ryuta Morihara, Yong Huang, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Koji Abe Source Type: research

Wegener's Granulomatosis Presenting as Wallenberg Syndrome: A Case Report
Granulomatosis with polyangiitis (GPA), formerly known as Wegener's granulomatosis, a vasculitis affecting small and medium sized vessels usually affects the upper and lower respiratory tract, the kidneys, and the eyes. Neurologic manifestation in central nervous system (CNS) is less frequent than the peripheral and usually is in form of stroke. Few cases of lateral medullary ischemic stroke (Wallenberg syndrome) due to GPA have been reported. A 41 year-old female, presented with acute vertigo, nausea/vomiting, hiccups, dysphagia. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 23, 2019 Category: Neurology Authors: Maziar Emamikhah, Farzad Sina, Mahisa Mokhtari, Fatemeh Shirani, Mohammadreza Asadipanah Tags: Case Report Source Type: research

Wegener's Granolomatosis Presenting as Wallenberg Syndrome: A Case Report
Granulomatosis with polyangiitis (GPA), formerly known as Wegener's granulomatosis, a vasculitis affecting small and medium sized vessels usually affects the upper and lower respiratory tract, the kidneys, and the eyes. Neurologic manifestation in central nervous system (CNS) is less frequent than the peripheral and usually is in form of stroke. Few cases of lateral medullary ischemic stroke (Wallenberg syndrome) due to GPA have been reported. A 41 year-old female, presented with acute vertigo, nausea/vomiting, hiccups, dysphagia. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 23, 2019 Category: Neurology Authors: Maziar Emamikhah, Farzad Sina, Mahisa Mokhtari, Fatemeh Shirani, Mohammadreza Asadipanah Tags: Case Report Source Type: research

Corrigendum to ‘Features of Patients Aged 80 Years or Older with Embolic Stroke of Undetermined Source’ [Journal of Stroke and Cerebrovascular Diseases Volume 28 (February 2019) 251-255]
The authors regret that the units for brain natriuretic peptide (BNP), D-dimer (DD), left atrial diameter (LAD), premature atrial complexes (PAC) and intima media thickness (IMT) were incorrect in Table 2 at the time of publishing. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 23, 2019 Category: Neurology Authors: Tomonori Iwata, Kazunari Honma, Hideyuki Hanano, Ayana Kadokura, Eiichiro Nagata, Shunya Takizawa Tags: Corrigendum Source Type: research

Authors ’ Response to “Barometric Pressure in Cerebral Amyloid Angiopathy: A Pressure to Bleed?”
The authors thank Dr. Vilanilam et al ’ comments to our recent article entitled “The Influence of Weather on the Incidence of Primary Spontaneous Intracerebral Hemorrhage (sICH)”. A study exclusively examining the influence of weather on patients with possible/probable cerebral amyloid angiopathy (CAA) may be helpful, although one would have to assume that elevations in blood pressure play no role in causing sICH in these patients. Furthermore, establishing a priori knowledge of normotension and CAA pathology would be difficult, and would require a large study population with serial blood pressure monitor...
Source: Journal of Stroke and Cerebrovascular Diseases - April 20, 2019 Category: Neurology Authors: Rajeev Kumar Garg, Bichun Ouyang, Vishal Pandya, Raquel Garcia-Cano, Ivan Da Silva, Deborah Hall, Sayona John, Thomas Pritchett Bleck, Max Berkelhammer Tags: Letter to the Editor Source Type: research

Acute Stroke Trial Enrollment through a Telemedicine Network: A 12-Year Experience
A major barrier to acute stroke trial enrollment is timely access to participating centers. Establishing referral relationships via telemedicine may broaden trial access. We sought to understand the utilization of telemedicine in trial enrollment at a large academic center. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 20, 2019 Category: Neurology Authors: Hazem Shoirah, Lawrence R. Wechsler, Tudor G. Jovin, Ashutosh P. Jadhav Source Type: research

Repetitive Episodic Isolated Vertigo in a Patient with Cerebellar Infarction
We report the case of a 63-year-old man with multiple atherosclerotic risk factors and atrial fibrillation who showed repeated episodes of isolated vertigo. His repeated vertigo was short-lasting and was often triggered by body position, mimicking benign paroxysmal positional vertigo. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 20, 2019 Category: Neurology Authors: Miyu Usui, Takafumi Mashiko, Masuko Tsuda, Masayuki Suzuki, Kosuke Matsuzono, Tadashi Ozawa, Yonhee Kim, Haruo Shimazaki, Reiji Koide, Ryota Tanaka, Shigeru Fujimoto Tags: Case Report Source Type: research

Total Antioxidant Capacity Predicts Outcome in Acute Ischemic Stroke Subtypes in Egyptian Patients
Background: Oxidative stress after ischemic stroke contributes to neuronal cell injury. We tried to demonstrate an association between total antioxidant capacity (TAC) levels and outcomes after acute ischemic stroke (AIS). Methods: We enrolled 60 patients (36 females and 24 males) who were admitted to our hospital due to AIS, in addition to 30 age and sex-matched healthy controls. TAC levels were measured on day 1 of stroke onset, the relationships between TAC levels, stroke subtypes, and clinical outcomes based on the National Institutes of Health Stroke Scale and modified Rankin scale upon discharge were evaluated. (Sour...
Source: Journal of Stroke and Cerebrovascular Diseases - April 20, 2019 Category: Neurology Authors: Nesma A.M. Ghonimi, Mohamed E. Mahdy, Osama A. Abdel Salam Source Type: research

Paradoxical Brain Embolism Caused by Isolated Pulmonary Arteriovenous Fistula Successfully Treated with Recombinant Tissue Plasminogen Activator
Pulmonary arteriovenous fistula (PAVF), a vessel malformation connecting the pulmonary circulation to the systemic circulation while bypassing the pulmonary capillaries, can cause paradoxical cerebral infarction. It is often associated with hereditary hemorrhagic telangiectasia (HHT), a genetic disease characterized by multiple dermal, mucosal, and visceral telangiectasia causing recurrent bleeding. Paradoxical cerebral embolism caused by PAVF without HHT is rare. Here, we report a patient with isolated PAVF who experienced an ischemic stroke caused by a paradoxical embolism from deep venous thrombosis; the patient was suc...
Source: Journal of Stroke and Cerebrovascular Diseases - April 18, 2019 Category: Neurology Authors: Itsuki Hasegawa, Takato Abe, Toshikazu Mino, Kousuke Okamoto, Akitoshi Takeda, Yoshiaki Itoh Tags: Case Report Source Type: research

Effectiveness of Nonvitamin K Antagonist Oral Anticoagulants and Warfarin for Preventing Further Cerebral Microbleeds in Acute Ischemic Stroke Patients with Nonvalvular Atrial Fibrillation and At Least One Microbleed: CMB-NOW Multisite Pilot Trial
Nonvitamin K antagonist oral anticoagulants (NOACs) are considered superior, or at least noninferior, to warfarin in preventing stroke or systemic embolism in patients with nonvalvular atrial fibrillation. Here, we recruited acute ischemic stroke patients with nonvalvular atrial fibrillation and at least one cerebral microbleed (CMB), and evaluated the proportion of patients who had an increased number of CMBs (%) after receiving anticoagulant therapy with NOACs or with warfarin for 12 months. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 18, 2019 Category: Neurology Authors: Mutsumi Yokoyama, Atsushi Mizuma, Tohru Terao, Fumiaki Tanaka, Kazutoshi Nishiyama, Yasuhiro Hasegawa, Eiichiro Nagata, Shigeru Nogawa, Hiroyuki Kobayashi, Noriharu Yanagimachi, Takashi Okazaki, Kazuo Kitagawa, Shunya Takizawa, for the CMB-NOW Study Inves Source Type: research

Risk Factors for Pressure Sores in Hospitalized Acute Ischemic Stroke Patients
Acute ischemic stroke patients are a group at high risk for pressure sores. It is important to identify risk factors for pressure sores in acute ischemic stroke patients in order to facilitate early adoption of appropriate preventive and treatment measures. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 17, 2019 Category: Neurology Authors: Xiaoling Liao, Yi Ju, Gaifen Liu, Xingquan Zhao, Yilong Wang, Yongjun Wang Source Type: research

Association Between Baseline Serum Ferritin and Short-term Outcome of Intracerebral Hemorrhage: A Meta-Analysis
Background: Intracerebral hemorrhage is a devastating disease. In recent years, the association of between baseline serum ferritin and prognosis of intracerebral hemorrhage is an interesting issue. Although some of the studies have shown that baseline serum ferritin can predict the prognosis of intracerebral hemorrhage, there is no clear evidence that baseline serum ferritin can be used as an independent predictor of intracerebral hemorrhage. Methods: Electronic databases through November 2018 were searched to identify relevant studies that examined association between baseline serum ferritin and prognosis of intracerebral...
Source: Journal of Stroke and Cerebrovascular Diseases - April 15, 2019 Category: Neurology Authors: Mijuan Zhang, Wei Li, Tao Wang, Qian Zhang Tags: Review Article Source Type: research

Increasing the Risk of Stroke by Opium Addiction
Stroke is among the leading causes of mortality and morbidity in the world. Besides the identified risk factor, Ischemic stroke evidence show drug use develops or exacerbates the atherosclerotic process. The current study aimed at comparing cerebrovascular ultrasounds ’ changes in addicted and nonaddicted people who developed ischemic stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 15, 2019 Category: Neurology Authors: Seyed Mohammad Mousavi-Mirzaei, Abolfazl Talebi, Alireza Amirabadizadeh, Samaneh Nakhaee, Ghodsieh Azarkar, Omid Mehrpour Source Type: research

Masthead
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 13, 2019 Category: Neurology Source Type: research

Editorial Board
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 13, 2019 Category: Neurology Source Type: research

Table of Contents
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 13, 2019 Category: Neurology Source Type: research

Comment on “The Enhancing Effect of Focused Ultrasound on TNK-Tissue Plasminogen Activator-Induced Thrombolysis Using an In Vitro circulating Flow Model”
The objective of the study by Papadopoulos et al. was to evaluate the effect of various parameters such as temperature, focused ultrasound (FUS) energy, FUS frequency, acoustic power, and microbubble administration on tenecteplase (TNK)-tissue plasminogen activator-mediated thrombolysis and therefore, to establish a treatment protocol that maximize thrombolysis efficacy. For this purpose, an in vitro circulating flow clot model was designed to reproduce a middle cerebral artery occlusion. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 13, 2019 Category: Neurology Authors: Nicolas Papadopoulos, Christakis Damianou Tags: Letter to the Editor Source Type: research

Recent Trends in Electively Treated Unruptured Intracranial Aneurysms
Background and Purpose: To determine recent treatment and outcome trends in patients undergoing elective surgical clipping (SC) or endovascular therapy (EVT) for unruptured intracranial aneurysms (UIAs) in the United States. Methods: Data were extracted and analyzed from the National Inpatient Sample, Healthcare Cost and Utilization Project, Agency for Healthcare Research and Quality for all patients admitted for elective EVT or SC of UIAs between 2011 and 2014. Treatment trends, in-hospital mortality, complication rates, length of stay (LOS) and total hospital costs were evaluated and analyzed. (Source: Journal of Stroke ...
Source: Journal of Stroke and Cerebrovascular Diseases - April 11, 2019 Category: Neurology Authors: Hisham Salahuddin, Nauman Siddiqui, Alicia C. Castonguay, Mark Johnson, Syed F. Zaidi, Mouhammad A. Jumaa Source Type: research

Pretreatment Blood Pressure is a Simple Predictor of Hemorrhagic Infarction after Intravenous Recombinant Tissue Plasminogen Activator (rt-PA) Therapy
Hemorrhagic infarction (HI) is among the most severe complications that can occur following the administration of intravenous recombinant tissue plasminogen activator (rt-PA). In the present study, we aimed to determine the optimal cut-off points of blood pressure (BP) for HI after rt-PA treatment, and to compare our findings with those for other prediction models. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 11, 2019 Category: Neurology Authors: Ryo Ohtani, Michikazu Nakamura, Shinsuke Nirengi, Osamu Kawakami, Jumpei Togawa, Kento Doi, Makoto Sainouchi, Yasuhiro Kuwata, Masaki Takata, Yuichi Masuda, Ryota Matsunari, Kiyoaki Takeda, Tetsuya Tsukahara, Naoki Sakane Source Type: research

Improving Prognostic Evaluation by 4D CTA for Endovascular Treatment in Acute Ischemic Stroke Patients: A Preliminary Study
Objective: We aim to use 4D CTA with a comprehensive and objective scoring system to assess collateral circulation, and explore the value of prognosis prediction in endovascular treated patients. Methods: Thirty-four patients with unilateral anterior circulation large vessels occlusion were reviewed in this study retrospectively. Single-phase CTA (sCTA) and 4D CTA acquired by CT perfusion scanning were analyzed for collateral circulation assessment. The collateral vessels were scored 0-4 according to modified collateral circulation scoring based on 4D CTA. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 10, 2019 Category: Neurology Authors: Ruoyao Cao, Peng Qi, Yinhong Liu, Xinxin Ma, Zhengyin Shen, Juan Chen Source Type: research

Comment on “The Enhancing Effect of Focused Ultrasound on TNK-Tissue Plasminogen Activator-Induced Thrombolysis using an In Vitro Circulating Flow Model”
We recently read the article by Papadopoulos et al published in the Journal of Stroke and Cerebrovascular Diseases.1 However, we have some concerns about the methodology and their potential consequences on the interpretation of results. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 10, 2019 Category: Neurology Authors: Laurent Auboire, Jean-Michel Escoffre Tags: Letter to the Editor Source Type: research

Predictors of Oral Feeding Resumption after Stroke in a Rehabilitation Hospital: A Retrospective Study
Background: Dysphagia is common after stroke, requiring exclusive enteral feeding in 20% of patients. Recovery of oral feeding is associated with increased quality of life, better functional outcomes, and decreased mortality rates. However, evidence is heterogeneous and not conclusive on which factors are predictive of oral feeding recovery for stroke patients in rehabilitation units. Aim: To investigate predictors of complete oral feeding recovery. Design: Retrospective study. Setting: Intensive inpatient rehabilitation hospital. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 10, 2019 Category: Neurology Authors: Irene Calvo, Nicole Pizzorni, Giulia Gilardone, Flavia Mayer, Nicola Vanacore, Valentina Buraschi, Marco Gilardone, Massimo Corbo Source Type: research

Predictors for Functional Outcome in Patients with Aneurysmal Subarachnoid Hemorrhage Who Completed In-Hospital Rehabilitation in a Single Institution
Background: Although many studies evaluated independent prognosis factors of functional outcome in patients with subarachnoid hemorrhage (SAH) at a suitable time point, some patients take a long time to get functional improvement. The purpose of this study is to evaluate predictors for functional outcome in SAH patients who underwent surgical clipping and in-hospital rehabilitation in our single institution using Modified Rankin Scale (MRS) and Barthel Index (BI). Methods: Two-hundred fifty-one SAH patients were admitted to our hospital from January 2008 to December 2017. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 10, 2019 Category: Neurology Authors: Yushin Takemoto, Yu Hasegawa, Akihito Hashiguchi, Koichi Moroki, Hajime Tokuda, Akitake Mukasa Source Type: research

Angiographical Jaggy Sign of Remnant M2 Occlusion during Acute Mechanical Thrombectomy
In this study, we focused on the angiographical findings of remnant occlusion. Methods: Among 83 patients who underwent mechanical thrombectomy for the acute internal carotid artery or proximal middle cerebral artery (M1) occlusion, 25 patients (30%) intraoperatively exhibited the remnant M2 occlusion, in spite of the recanalization of the other M2. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 10, 2019 Category: Neurology Authors: Rei Yamaguchi, Masanori Aihara, Tatsuya Shimizu, Koji Sato, Hiroya Fujimaki, Ken Asakura, Masahiko Tosaka, Yuhei Yoshimoto Source Type: research

Transcranial Optical Monitoring of Cerebral Hemodynamics in Acute Stroke Patients during Mechanical Thrombectomy
Introduction: Mechanical thrombectomy is revolutionizing treatment of acute stroke due to large vessel occlusion (LVO). Unfortunately, use of the modified Thrombolysis in Cerebral Infarction score (mTICI) to characterize recanalization of the cerebral vasculature does not address microvascular perfusion of the distal parenchyma, nor provide more than a vascular “snapshot.” Thus, little is known about tissue-level hemodynamic consequences of LVO recanalization. Diffuse correlation spectroscopy (DCS) and diffuse optical spectroscopy (DOS) are promising methods for continuous, noninvasive, contrast-free transcrani...
Source: Journal of Stroke and Cerebrovascular Diseases - April 8, 2019 Category: Neurology Authors: Rodrigo M. Forti, Christopher G. Favilla, Jeffrey M. Cochran, Wesley B. Baker, John A. Detre, Scott E. Kasner, Michael T. Mullen, Steven R. Mess é, W. Andrew Kofke, Ramani Balu, David Kung, Bryan A. Pukenas, Neda I. Sedora-Roman, Robert W. Hurst, Omar A. Source Type: research

Left Thalamus Arteriovenous Malformation Secondary to Radiation Therapy of Original Vermian Arteriovenous Malformation: Case Report
A 70-year-old gentleman with history of hypothyroidism, hyperlipidemia, hypertension, and right superior cerebellar aneurysm presented to the neurosurgery service in 2008 with vertigo. Diagnostic cerebral angiography performed that year demonstrated a vermian arteriovenous malformations (AVM). The patient underwent stereotactic proton beam radiosurgery, which resulted in a decrease in flow and size of the lesion, and the patient was lost to follow-up. Now at the age of 80, the patient presented with acute gait instability. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 8, 2019 Category: Neurology Authors: Carlos Torres-Quinones, Matthew J. Koch, Scott B. Raymond, Aman Patel Tags: Case Report Source Type: research

Association of Hyponatremia and Risk of Short- and Long-Term Mortality in Patients with Stroke: A Systematic Review and Meta-Analysis
Hyponatremia is the most common electrolyte disorder in the clinic practice and it is closely related to the prognosis of various diseases. Studies reported that hyponatremia increased the risk of stroke mortality while yielded inconsistent findings during the follow-up period. Thus, a systematic review and meta-analysis to assess the relationship between hyponatremia and the short-term (within 90 days) and long-term (more than 1 year) prognosis of stroke patients was conducted. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 6, 2019 Category: Neurology Authors: Zhongyun Chen, Qingxia Jia, Chunyan Liu Source Type: research

Cerebral Venous Sinus Incision for Surgical Thrombectomy Combined with Thrombolysis During Decompressive Craniectomy for Malignant Cerebral Venous Sinus Thrombosis Complicated with Cerebral Hernia
This report describes an approach performed on 2 patients diagnosed with CVST combined both thrombectomy and thrombolysis with decompressive craniectomy through incising the superior sagittal sinus. The general procedure of the operation is as follows. The anterior part of the superior sagittal sinus was exposed firstly. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 5, 2019 Category: Neurology Authors: Yan'gang Wang, Yang Wang, Junjie Zhang, Shunli Du, Jiabin Wu Tags: Case Report Source Type: research

Factors Influencing Oral Intake Improvement and Feeding Tube Dependency in Patients with Poststroke Dysphagia
Objective: To assess ischemic stroke patients regarding the relationship between lesion locations, swallowing impairment, medical and demographic factors and (1) oral intake improvement and (2) feeding tube dependency at discharge from their acute hospital stay. Methods: We conducted an exploratory, retrospective observational longitudinal cohort study of acute, first-ever, ischemic stroke patients. Patients who had an initial nonoral feeding recommendation from a speech and language pathologist and who underwent a modified barium swallow study within their hospital stay were included. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 5, 2019 Category: Neurology Authors: Janina Wilmskoetter, Leonardo Bonilha, Bonnie Martin-Harris, Jordan J. Elm, Janet Horn, Heather S. Bonilha Source Type: research

Effects of capsaicin on swallowing function in stroke patients with dysphagia: A randomized controlled trial
Dysphagia is a common complication after acute stroke. While there are several innovative treatments being tested to improve the swallowing function of stroke patients with dysphagia, our aim is to explore the use of readily available natural capsaicin in stroke patients with dysphagia. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 4, 2019 Category: Neurology Authors: Zhuo Wang, Lingling Wu, Qi Fang, Meifen Shen, Lulu Zhang, Xueyun Liu Source Type: research

Systematic Review on Effectiveness of shoulder taping in Hemiplegia
Shoulder pain and subluxation are the commonly encountered problems among subjects with hemiplegia. Rehabilitating the shoulder following stroke is a challenging task among physiotherapists in rehabilitation set up. There is a need to validate the effectiveness of externally applied taping materials in hemiplegic shoulder. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 4, 2019 Category: Neurology Authors: Hariharasudhan Ravichandran, Balamurugan Janakiraman, Subramanian Sundaram, Berihu Fisseha, Tsiwaye Gebreyesus, Asmare Yitayeh Gelaw Source Type: research

Pneumonia and Risk of Serious Adverse Outcomes in Hospitalized Strokes in Thailand
Background: The impact of stroke associated pneumonia (SAP) on stroke complications is not well understood; we aimed to study the association between SAP and adverse outcomes including in-hospital mortality, prolonged length of stay and the risk of developing common serious complications (sepsis, respiratory failure, and convulsions). Methods: We retrospectively analyzed data from a cohort of 610,668 stroke patients drawn from the Universal Coverage Health Security Scheme (a national insurance database) in Thailand which covers ∼80% of the Thai population. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 4, 2019 Category: Neurology Authors: Raphae S. Barlas, Allan B. Clark, Joao H. Bettencourt-Silva, Kittisak Sawanyawisuth, Kannikar Kongbunkiat, Narongrit Kasemsap, Somsak Tiamkao, Phyo Kyaw Myint Source Type: research

The CADASIL Scale-J, A Modified Scale to Prioritize Access to Genetic Testing for Japanese CADASIL-Suspected Patients
Background: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is definitely diagnosed by genetic testing. Such testing involves the analysis of exons 2-24 of NOTCH3, which encode the epidermal growth factor-like repeat domain, where CADASIL mutations are localized. We previously reported clinical diagnostic criteria for screening CADASIL-suspected Japanese patients prior to genetic testing. Because of its high sensitivity but low specificity, most patients need to undergo genetic testing. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 4, 2019 Category: Neurology Authors: Takashi Koizumi, Ikuko Mizuta, Akiko Watanabe-Hosomi, Mao Mukai, Ai Hamano, Jun Matsuura, Tomoyuki Ohara, Toshiki Mizuno Source Type: research

The Relevance of Vascular Endothelial Growth Factor, Hypoxia Inducible Factor-1 Alpha, and Clusterin in Carotid Plaque Instability
Background: Stroke is one of the leading causes of morbidity and mortality. Thromboembolism, as a major cause of carotid artery-related stroke, can be caused by plaque rupture which is associated with neoangiogenesis within the carotid plaque. Aim: We sought to investigate a possible correlation between angiogenesis-related factors and preoperative neurological manifestations in patients with internal carotid artery stenosis, for a better understanding of thromboembolism in internal carotid artery stenosis-related stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 2, 2019 Category: Neurology Authors: Jelena Basic, Stefan Stojkovic, Afshin Assadian, Sabine Rauscher, Nikolaus Duschek, Christoph Kaun, Johann Wojta, J ürgen Falkensammer Source Type: research