Is Management of Central Retinal Artery Occlusion the Next Frontier in Cerebrovascular Diseases?
I was interested to read the long review article by Limaye and colleagues entitled “Is management of central retinal artery occlusion the next frontier in cerebrovascular diseases?”1 (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 26, 2018 Category: Neurology Authors: Sohan Singh Hayreh Source Type: research

Health-Related Quality of Life and Fatigue After Transient Ischemic Attack and Minor Stroke
Studies suggest that fatigue and cognitive impairment may be present after transient ischemic attack (TIA) or minor stroke, but little is known about consequences in daily life. The main aim was to explore the presence of fatigue, cognitive impairment, and consequences in daily life after minor stroke-TIA. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 26, 2018 Category: Neurology Authors: Jos é M. Ramírez-Moreno, Pedro Muñoz-Vega, Sandra Bartolomé Alberca, Diego Peral-Pacheco Source Type: research

Hemorrhagic Transformation After Acute Ischemic Stroke in Atrial Fibrillation Patients
We read with interest the study by Ge, Wan-Qian et al.1 One of the results from the study was that the risk of hemorrhagic transformation (HT) was higher in patients with atrial fibrillation (AF). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 26, 2018 Category: Neurology Authors: George K. Vilanilam, Mohammed K. Badi, Bhavya Yarlagadda, Lela Okromelidze Source Type: research

MiR-34b Protects Against Focal Cerebral Ischemia-Reperfusion (I/R) Injury in Rat by Targeting Keap1
Ischemic stroke is one of the leading causes of death and disability globally and has been regarded as a major public health problem. Understanding the mechanism of ischemia/reperfusion (I/R)-induced oxidative stress injury may provide new treatment for ischemic stroke. Kelch-like ECH-associated protein 1 (Keap1)/ NF-E2-related factor 2 (Nrf2)/ antioxidant response elements (ARE) signaling pathway has been considered to be the major cellular defense against oxidative stress. In the present study, our objective is to evaluate the molecular mechanism of miR-34b/Keap1 in modulating focal cerebral I/R induced oxidative injury....
Source: Journal of Stroke and Cerebrovascular Diseases - October 24, 2018 Category: Neurology Authors: Rong Huang, Juan Ma, Bo Niu, Jin Li, Jian Chang, Yanrui Zhang, Peng Liu, Xinping Luan Source Type: research

Isosteviol Sodium Protects Neural Cells Against Hypoxia-Induced Apoptosis Through Inhibiting MAPK and NF- κB Pathways
Stevioside, isolated from the herb Stevia rebaudiana, has been widely used as a food sweetener all over the world. Isosteviol Sodium (STV-Na), an injectable formulation of isosteviol sodium salt, has been proved to possess much greater solubility and bioavailability and exhibit protective effects against cerebral ischemia injury in vivo by inhibiting neuron apoptosis. However, the underlying mechanisms of the neuroprotective effects STV-Na are still not completely known. In the present study, we investigated the effects of STV-Na on neuronal cell death caused by hypoxia in vitro and its underlying mechanisms. (Source: Jour...
Source: Journal of Stroke and Cerebrovascular Diseases - October 24, 2018 Category: Neurology Authors: Kai-Lun Zhong, Min-Yi Lu, Fei Liu, Ying Mei, Xue-Ju Zhang, Hao Zhang, Jie Zan, Xiao-Ou Sun, Wen Tan Source Type: research

The NAG Scale: Noble Predictive Scale for Hematoma Expansion in Intracerebral Hemorrhage
We appreciate Dr. Hegde's interest in our study concerning the outcome of intracerebral hemorrhage (ICH) patients with a NAG (NAG stands for initial of 3 factors, NIHSS, Anticoagulants, and Glucose) score 2. We reviewed their clinical data again and carefully evaluated the same. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 24, 2018 Category: Neurology Authors: Kenichi Sakuta, Teppei Komatsu, Kenichiro Sakai, Yuka Terasawa, Hidetaka Mitsumura, Yasuyuki Iguchi Tags: Letter to the Editor Source Type: research

Predictors of Direct Enteral Tube Placement After Acute Stroke
To determine predictors of direct enteral tube (DET) placement after acute stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 24, 2018 Category: Neurology Authors: Raed A. Joundi, Gustavo Saposnik, Rosemary Martino, Jiming Fang, Moira K. Kapral Source Type: research

Impact of Relative Blood Glucose Changes on Mortality Risk of Patient with Acute Ischemic Stroke and Treated with Mechanical Thrombectomy
This study aimed to use stress hyperglycemia ratio (SHR) to evaluate the influence of pretreatment relative blood glucose changes on mortality risk after MT. Methods: The study retrospectively enrolled 321 acute ischemic stroke patients treated with MT. SHR was calculated as random blood glucose at admission divided by average blood glucose which estimated by glycosylated hemoglobin (HbA1c). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 24, 2018 Category: Neurology Authors: Ling Wang, Zhiming Zhou, Xiguang Tian, Huaiming Wang, Dong Yang, Yonggang Hao, Zhonghua Shi, Min Lin, Zhen Wang, Dequan Zheng, Mingyi Tu, Wenjie Zi, Gelin Xu, Xinfeng Liu, for the ACTUAL investigators Source Type: research

Cerebral Vasoreactivity in Children with Sickle Cell Disease: A Transcranial Doppler Study
I read with great interest the original article by Macedo-Campos et al1 titled “Cerebral Vasoreactivity in Children with Sickle Cell Disease: A Transcranial Doppler Study.” Authors have explored the cerebrovascular reactivity assessed by breath-holding index (BHI) in the children with sickle cell disease (SCD). They have reported the impaired cerebrovascular reactivity in the children with SCD as compared to that of control subjects. However, few potential methodological limitations need to be addressed regarding this study. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 24, 2018 Category: Neurology Authors: Kiran Prakash Tags: Letter to the Editor Source Type: research

Features of Patients Aged 80 Years or Older with Embolic Stroke of Undetermined Source
In this study, we investigated the features of this condition in patients greater than or equal to 80 years of age. Methods: All patients with acute ischemic stroke in our hospital underwent diffusion-weighted imaging, magnetic resonance angiography, T2-weighted imaging, and fluid-attenuated inversion recovery sequence imaging. Embolic stroke of undetermined source was defined as a radiologically confirmed nonlacunar brain infarct on diffusion-weighted imaging without (1) extracranial or intracranial atherosclerosis causing greater than or equal to 50% luminal stenosis in arteries supplying the ischemic area, (2) major-ris...
Source: Journal of Stroke and Cerebrovascular Diseases - October 24, 2018 Category: Neurology Authors: Tomonori Iwata, Kazunari Honma, Hideyuki Hanano, Ayana Kadokura, Eiichiro Nagata, Shunya Takizawa Source Type: research

Is Management of Central Retinal Artery Occlusion the Next Frontier in Cerebrovascular Diseases?
We thank the editors for allowing us to reply to the exhaustive commentary by Professor Sohan Singh Hayerh to our recent review.1 We note that his criticisms of our paper are quite similar to those that he submitted in response to the EAGLE trial.2 The response by Feltgen et al3 has answered the limitations of the points he raises and hence we do not wish to again reiterate the same here. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 24, 2018 Category: Neurology Authors: Kaustubh Limaye, Harold P. Adams Tags: Letter to the Editor Source Type: research

Successful mechanical thrombectomy in stroke with thrombolysis-associated intracerebral hemorrhage —a case report
Intravenous thrombolysis and mechanical thrombectomy are the standard of care for patients with acute ischemic stroke with large vessel occlusion. Intracerebral hemorrhage is a main complication of intravenous thrombolysis, however, no data are available on the efficacy and safety of mechanical thrombectomy in patients with thrombolysis-associated intracerebral hemorrhage. This constellation is expected to become more frequent as increasing numbers of patients are treated under the drip-and-ship paradigm. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 24, 2018 Category: Neurology Authors: Johannes M. Weller, Elke Hattingen, Gabor C. Petzold, Felix J Bode Source Type: research

Corrigendum to “Predicting Motor and Cognitive Improvement Through Machine Learning Algorithm in Human Subject That Underwent a Rehabilitation Treatment in the Early Stage of Stroke” [J Stroke Cerebrovasc Dis 27/11 (2018) 2962-2972]
The authors would like to inform the readers of a needed clarification in this article. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 24, 2018 Category: Neurology Authors: Patrizio Sale, Giorgio Ferriero, Lucio Ciabattoni, Anna Maria Cortese, Giovanni Gentile, Francesco Ferracuti, Luca Romeo, Francesco Piccione, Stefano Masiero Tags: Corrigendum Source Type: research

Prolonged Autonomic Fluctuation Derived from Parasympathetic Hypertonia after Carotid Endarterectomy but not Stenting
Carotid endarterectomy (CEA) is a standard treatment for carotid artery stenosis, but the incidence after periprocedural myocardial infarction (MI) is not negligible. The mechanism for the higher risk of MI following CEA compared with the carotid artery stenting (CAS) is unclear. We hypothesized that it may be explained by different autonomic nervous responses. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 23, 2018 Category: Neurology Authors: Mari Amino, Masataka Nakano, Takashi Komatsu, Reisuke Yoshizawa, Fusanori Kunugita, Ken Kiyono, Norihiko Shinozaki, Kuniaki Ogasawara, Yoshihiro Morino, Koichiro Yoshioka, Yuji Ikari Source Type: research

Recurrent Cerebral Infarction Due to Benign Uterine Myoma
We report a case of recurrent ischemic stroke in a middle-aged woman who had a benign uterine tumor. After excision, there was no recurrence for 2 years. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 23, 2018 Category: Neurology Authors: Eiko Higuchi, Sono Toi, Yuka Shirai, Satoko Mizuno, Hiromi Onizuka, Yoji Nagashima, Kazunori Hashimoto, Kazuo Kitagawa Tags: Case Reports Source Type: research

SIRT1: The Value of Functional Outcome, Stroke-Related Dementia, Anxiety, and Depression in Patients with Acute Ischemic Stroke
Background: The outcome of ischemic stroke depends on multiple factors and their function of each other. Studies have shown that Sirtuin1 (SIRT1) plays a chief role in the key procedure during ischemia/hypoxia by protecting against cellular stress and controlling the metabolic pathways. Aims: To explore the alterations in serum SIRT1 concentrations in acute ischemic stroke (AIS) patients and the relationship between SIRT1 and poststroke dementia, anxiety, and depression. Methods: One hundred and twenty four consecutive patients with clinically diagnosed AIS were recruited to participate in the study. (Source: Journal of St...
Source: Journal of Stroke and Cerebrovascular Diseases - October 23, 2018 Category: Neurology Authors: Xue Liang, Yang Liu, Shiyu Jia, Xiaomin Xu, Meixue Dong, Youdong Wei Source Type: research

Intravenous Thrombolysis Is Safe and Effective for the Cryptogenic Stroke in China: Data From the Thrombolysis Implementation and Monitor of Acute Ischemic Stroke in China (TIMS-China)
The intravenous thrombolysis (IVT) with recombinant tissue plasminogen activator (rt-PA) therapy is safe and efficient during the treatment of acute ischemic stroke. Nonetheless, the different outcomes among various stroke subgroups have limited data with regard to the safety and efficacy of cryptogenic stroke (CS). The present study compared the safety and efficacy when IVT with rt-PA was used for the treatment of CS and the other stroke subtypes. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 23, 2018 Category: Neurology Authors: Yu Fan, Xiaoling Liao, Yuesong Pan, Kehui Dong, Yilong Wang, Yongjun Wang, Thrombolysis Implementation and Monitor of Acute Ischemic Stroke in China (TIMS-China) Investigators Source Type: research

Early Identification of Protein S K196E Mutation in a Patient With Cerebral Venous Thrombosis: A Case Report
We report a case of CVT that was diagnosed as having PS K196E mutation at the initial thrombotic event. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 20, 2018 Category: Neurology Authors: Kyohei Fujita, Kazutaka Sonoda, Toshiyuki Miyata, Masafumi Ihara, Kazunori Toyoda, Masatoshi Koga Source Type: research

Impact of Treatment Time on the Long-Term Outcome of Stroke Patients Treated With Mechanical Thrombectomy
To assess the long-term functional outcome of stroke in patients treated with mechanical thrombectomy (MT) performed during work hours (on-hours) versus after-hours, weekends, and official holidays (off-hours). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 19, 2018 Category: Neurology Authors: Eyad Almallouhi, Sami Al Kasab, Jillian B. Harvey, Christopher Reardon, Ali Alawieh, Tarun Girotra, Patricia Aysse, Raymond D. Turner, Christine A. Holmstedt Source Type: research

Response to “The NAG Scale: Noble Predictive Scale for Hematoma Expansion in Intracerebral Hemorrhage”
We read with great interest the article entitled “The NAG scale: Noble Predictive Scale for Hematoma Expansion in Intracerebral Hemorrhage” by Sakuta et al1 Hematoma expansion is an important predictor of mortality and is more significant in patients on oral anticoagulants.1,2 Identification of reliable and early predictors of hematoma growth is important in the treatment of Intracerebral Hemorrhage.2 (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 17, 2018 Category: Neurology Authors: Ajay Hegde Tags: Letter to the Editor Source Type: research

Predictors of Recurrent Hospitalizations and the Importance of These Hospitalizations for Subsequent Mortality After Incident Transient Ischemic Attack
We examined predictors of recurrent hospitalizations and the importance of these hospitalizations for subsequent mortality after incident transient ischemic attacks (TIA) that have not yet been investigated. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 17, 2018 Category: Neurology Authors: Mohammed Yousufuddin, Nathan Young, Jessica Shultz, Taylor Doyle, Karen M. Fuerstenberg, Kelsey Jensen, Kogulavadanan Arumaithurai, Mohammad H. Murad Source Type: research

Derivation of a Prediction Rule for Unfavorable Outcome after Ischemic Stroke in the Chinese Population
Efficient assessment of patients after ischemic stroke has important reference value for doctors to choose appropriate treatment for patients. Our study aimed to develop a new prognostic model for predicting outcomes 3 months after ischemic stroke among Chinese Population. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 16, 2018 Category: Neurology Authors: Haifeng Mao, Qianyi Wu, Peiyi Lin, Junrong Mo, Huilin Jiang, Shaopeng Lin, Timothy H. Rainer, Xiaohui Chen Source Type: research

Calpeptin Reduces Neurobehavioral Deficits and Neuronal Apoptosis Following Subarachnoid Hemorrhage in Rats
This study was undertaken to determine the effects of inhibition of calpain on neurological deficit and neuronal apoptosis following experimental SAH. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 15, 2018 Category: Neurology Authors: You-dong Zhou, Li Cai Source Type: research

Two Medullary Hemorrhage Cases Complicated by Respiratory Distress in the Early Phase
Medullary hemorrhage is quite rare among brain stem hemorrhage cases, thus the clinical course remains unclear. In the medulla oblongata, respiratory centers are located and previous reports indicate that medullary lesions have possible relationship with acute respiratory distress syndrome. This kind of respiratory failure is commonly caused by neurogenic pulmonary edema (NPE), which is defined as noncardiac noninfectious acute respiratory distress syndrome with changes in intracranial condition including cerebrovascular events. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 15, 2018 Category: Neurology Authors: Ryuichiro Yagi, Yoshinori Nishimoto, Satoshi Yamada, Hanae Nakashima, Kensuke Okada, Fumie Konoeda, Haruhiko Hoshino Tags: Case Studies Source Type: research

Application of High-Resolution CUBE Sequence in Exploring Stroke Mechanisms of Atherosclerotic Stenosis of Middle Cerebral Artery
This study aimed to analyze the vascular wall and atherosclerotic plaques of the middle cerebral artery (MCA) and compare their differences between patients with cerebral infarction and transient ischemic attack (TIA) using 3-dimensional fast-spin-echo T1-weighted sequence (namely CUBE). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 13, 2018 Category: Neurology Authors: Jianye Liang, Jun Guo, Dexiang Liu, Changzheng Shi, Liangping Luo Source Type: research

Overexpression of miR-582-5p Inhibits the Apoptosis of Neuronal Cells after Cerebral Ischemic Stroke Through Regulating PAR-1/Rho/Rho Axis
The purpose of this study was to explore the role of miR-582-5p/proteinase-activated receptors type I (PAR-1)/Rho/Rho in neuronal cell apoptosis after cerebral ischemic stroke (CIS). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 13, 2018 Category: Neurology Authors: Hongsheng Ding, Shan Gao, Lei Wang, Yan Wei, Meiyun Zhang Source Type: research

Isolated Anisocoria as a Presenting Stroke Code Symptom is Unlikely to Result in Alteplase Administration
Acute stroke codes may be activated for anisocoria, but how often these codes lead to a final stroke diagnosis or alteplase treatment is unknown. The purpose of this study was to assess the frequency of anisocoria in stroke codes that ultimately resulted in alteplase administration. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 13, 2018 Category: Neurology Authors: Victoria A. Chang, Dawn M. Meyer, Brett C. Meyer Source Type: research

Book Review of “Uncommon Causes of Stroke,” 3rd Ed. 2018, Edited by Louis Caplan and José Biller, DOI: 10.1017/9781316551684
The third edition of Uncommon Causes of Stroke,1 edited by Louis Caplan and Jos é Biller, is a comprehensive reference manual that belongs on the bookshelf of providers who care for patients with cerebrovascular diseases. Like its popular sister, Stroke Syndromes, the chapters are exhaustively researched and referenced and readily fill the gaps in our routine knowledge. Expand ed from the previous edition, the 77 chapters are organized into sections on infectious, inflammatory, and systemic conditions, hereditary and genetic conditions and malformations, vascular disorders affecting the eyes, ears, and brain, coagul...
Source: Journal of Stroke and Cerebrovascular Diseases - October 13, 2018 Category: Neurology Authors: Cathy Sila Source Type: research

Different Clinical Phenotypes of Embolic Stroke of Undetermined Source: A Subgroup Analysis of 86 Patients
This study researches clinically relevant phenotypes among ESUS patients. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 12, 2018 Category: Neurology Authors: Silvio Piffer, Valeria Bignamini, Umberto Rozzanigo, Piero Poletti, Stefano Merler, Elisabetta Gremes, Domenico Marco Bonifati Source Type: research

Adequate Adherence to Direct Oral Anticoagulant is Associated with Reduced Ischemic Stroke Severity in Patients with Atrial Fibrillation
The impact of adherence to direct oral anticoagulants (DOACs) is unknown. We aimed to assess the effects of preceding anticoagulation treatment on neurologic severity at admission and functional outcomes at discharge in patients with atrial fibrillation (AF) who developed acute ischemic stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 12, 2018 Category: Neurology Authors: Kazuo Yamashiro, Naohide Kurita, Ryota Tanaka, Yuji Ueno, Nobukazu Miyamoto, Kenichiro Hira, Sho Nakajima, Takao Urabe, Nobutaka Hattori Source Type: research

Addition of Suvorexant to Ramelteon Therapy for Improved Sleep Quality with Reduced Delirium Risk in Acute Stroke Patients
Delirium in acute stroke is associated with poor clinical outcome. The purpose of this study was to examine the effect of sleep medications on sleep quality and delirium in acute stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 12, 2018 Category: Neurology Authors: Kei Kawada, Tsuyoshi Ohta, Koudai Tanaka, Mitsuhiko Miyamura, Satoshi Tanaka Source Type: research

Bioccipital Lobe Hypoperfusion and Anton's Syndrome Resolution with Intravenous Thrombolysis
Anton's syndrome is a rare neurological disorder characterized by a combination of visual anosognosia and confabulation of visual experience, most often seen after bilateral ischemic damage to the posterior occipital cortex. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 10, 2018 Category: Neurology Authors: Lukas T. Rotkopf, Wolfgang G. Kunz, Felix G. Meinel, Annika Plate, S önke Langner, Matthias Klein, Kolja M. Thierfelder Source Type: research

Differential MicroRibonucleic Acid Expression in Cardioembolic Stroke
This study examines stroke-specific miRNA expression in large vessel territory cardioembolic stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 10, 2018 Category: Neurology Authors: Janhavi M. Modak, Meaghan Roy-O'Reilly, Liang Zhu, Ilene Staff, Louise D. McCullough Source Type: research

Sinusoidal Transcranial Direct Current Versus Galvanic Vestibular Stimulation for Treatment of Lateropulsion Poststroke
To compare the effects of Transcranial Direct Current Stimulation (tDCS) versus Galvanic Vestibular Stimulation (GVS) on Lateropulsion following stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 9, 2018 Category: Neurology Authors: Suzanne Babyar, Taiza Santos, Tenysson Will-Lemos, Suleimy Mazin, Dylan Edwards, Michael Reding Source Type: research

Plasma miR-126 and miR-143 as Potential Novel Biomarkers for Cerebral Atherosclerosis
Cerebral atherosclerosis is the most important mechanism for ischemic stroke. However, specific plasma biomarkers to assess atherosclerosis susceptibility are still lacking. Circulating miRNAs have been shown to be promising biomarkers for various pathologic conditions. We investigated whether plasma miR-126 and miR-143 could be used as biomarkers for identifying and evaluating cerebral atherosclerosis. Results showed that miR-143 and miR-126 might participate in the process of atherosclerosis and were minimally affected by cerebral infarction. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 9, 2018 Category: Neurology Authors: Jing Gao, Shuna Yang, Kun Wang, Qianwei Zhong, Aijun Ma, Xudong Pan Source Type: research

The Efficacy of Lower Extremity Mirror Therapy for Improving Balance, Gait, and Motor Function Poststroke: A Systematic Review and Meta-Analysis
Mirror therapy is less commonly used to target the lower extremity after stroke to improve outcomes but is simple to perform. This review and meta-analysis aimed to evaluate the efficacy of lower extremity mirror therapy in improving balance, gait, and motor function for individuals with stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 9, 2018 Category: Neurology Authors: Dennis R. Louie, Shannon B. Lim, Janice J. Eng Source Type: research

MMP-9 Upregulation is Attenuated by the Monoclonal TLR2 Antagonist T2.5 After Oxygen –Glucose Deprivation and Reoxygenation in Rat Brain Microvascular Endothelial Cells
Blood-brain barrier (BBB) disruption plays a key role in the pathophysiology of acute ischemic stroke. Matrix metalloproteinases-2/9 (MMP-2/9) have been shown to participate in the disruption of the BBB and hemorrhagic transformation after cerebral ischemia. Toll-like receptor 2 (TLR2) may also be correlated with endothelial cell injury during ischemia-reperfusion events. However, the correlation between MMP-2/9 and TLR2 on endothelial cells after ischemia has not yet been evaluated. The aim of the study was to evaluate the impact of TLR2 and MMP-2/9 on tight junction proteins (TJs) after oxygen –glucose deprivation ...
Source: Journal of Stroke and Cerebrovascular Diseases - October 8, 2018 Category: Neurology Authors: Hongyan Zhu, Rongrong Dai, Hao Fu, Qiang Meng Source Type: research

Handling of Missing Outcome Data in Acute Stroke Trials: Advantages of Multiple Imputation Using Baseline and Postbaseline Variables
In acute stroke randomized trials, missingness of final functional outcome data reduces study power and potentially biases findings of treatment effect. Best methods for handling missing outcome data have not been well delineated for diseases with monophasic onset and subsequent improvement, like acute stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 6, 2018 Category: Neurology Authors: Dashiell F. Young-Saver, Jeffrey Gornbein, Sidney Starkman, Jeffrey L. Saver Source Type: research

Secular Trends in the Background of Intracerebral Hemorrhage from 2010 to 2015
Direct oral anticoagulants (DOACs) were recently introduced for the clinical use in stroke prevention, and they are reported to show a lower risk of intracerebral hemorrhage (ICH) compared to warfarin. We were interested to know whether there is any change in clinical backgrounds of ICH patients to date. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 6, 2018 Category: Neurology Authors: Taizen Nakase, Junta Moroi, Tatsuya Ishikawa Source Type: research

Epidemiology and Outcomes of Ischemic Stroke and Transient Ischemic Attack in the Adult and Geriatric Population
Background: Rate of ischemic strokes and transient ischemic attacks (TIAs) increases with age. There is lack of evidence on how age affects treatment strategies and outcomes. Our aim is to compare epidemiology of ischemic strokes and TIAs in adult and geriatric populations including risk factors, treatment delivered, and outcomes. Design: We designed a retrospective cross-sectional review of patients admitted to neurology with diagnosis of stroke or TIA from 2010 to 2015. Obtained variables were: age, sex, risk factors, acute therapy, National Institutes of Health Stroke Scale on admission and discharge, and disposition. (...
Source: Journal of Stroke and Cerebrovascular Diseases - October 6, 2018 Category: Neurology Authors: Allison Navis, Rocio Garcia-Santibanez, Maryna Skliut Source Type: research

Left Atrial or Left Atrial Appendage Thrombus Resolution After Adjustment of Oral Anticoagulant Treatment
Background: There are few reports about non-vitamin K antagonist oral anticoagulant (NOAC) treatment for resolution of left atrium (LA) or left atrial appendage (LAA) thrombus. LAA thrombus is an important cause of cardiogenic cerebral thromboembolism, and the detection rate increases due to more and more patients receiving catheter ablation. However, the results from NOAC use for LA or LAA thrombus are still unknown in real-world practice. The aim of this study was to discover the resolution of LA or LAA thrombus after anticoagulant treatment in real-world practice. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 6, 2018 Category: Neurology Authors: Wei-Chieh Lee, Chih-Yuan Fang, Yung-Lung Chen, Hsiu-Yu Fang, Huang-Chung Chen, Wen-Hao Liu, Morgan Fu, Mien-Cheng Chen Source Type: research

Masthead
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 5, 2018 Category: Neurology Source Type: research

Editorial Board
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 5, 2018 Category: Neurology Source Type: research

Table of Contents
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 5, 2018 Category: Neurology Source Type: research

History of Carotid Occlusions: The Contribution of Egas Moniz
To describe the first cases of carotid occlusions identified by the Portuguese neurologist Egas Moniz while performing the cerebral angiography he invented. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 5, 2018 Category: Neurology Authors: Victor Oliveira Source Type: research

Stroke Epidemiology in Argentina. Design of a Population-Based Study in General Villegas (EstEPA)
Epidemiological data on stroke is scarce in Latin America. Estudio Epidemiol ógico Poblacional sobre Accidente Cerebrovascular (EstEPA) is a population-based program planned to assess prevalence, incidence, mortality, and burden of disease for stroke in the Department of General Villegas, province of Buenos Aires, Argentina. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 4, 2018 Category: Neurology Authors: Virginia A. Pujol Lereis, Mario O. Melcon, Maximiliano A. Hawkes, Maia M. Gomez Schneider, Daiana E. Dossi, Mat ías J. Alet, Guillermo P. Povedano, Claudio D. Gonzalez, Sebastián F. Ameriso Source Type: research

Does the Magnitude of the Electrocardiogram QT Interval Dispersion Predict Stroke Outcome?
QT dispersion, maximal interlead difference in QT interval on 12-lead electrocardiogram (ECG), measures cardiac repolarization abnormalities. Data are conflicting whether QT dispersion predicts adverse outcome in acute ischemic stroke (AIS) patients. Our objective is to determine if QT dispersion predicts: (1) short-term clinical outcome in AIS, and (2) stroke location (insular versus noninsular cortex). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 3, 2018 Category: Neurology Authors: Yitzchok S. Lederman, Clotilde Balucani, Leah R. Steinberg, Charles Philip, Jason M. Lazar, Jeremy Weedon, Gautam Mirchandani, Sarah Z. Weingast, Giovanna Viticchi, Lorenzo Falsetti, Mauro Silvestrini, James J. Gugger, David Aharonoff, Pirouz Piran, Zacha Source Type: research

Clinical Outcomes of Valvular versus Nonvalvular Atrial Fibrillation in Acute Anterior Circulation Occlusive Stroke Undergoing Endovascular Treatment
Thrombectomy is the first choice for cardioembolism due to atrial fibrillation (AF), however, whether valvular AF and nonvalvular AF had different safety and functional outcomes has not been reported yet. We aimed to investigate the differences between patients with valvular AF and patients with nonvalvular AF on safety and functional outcomes in acute large artery occlusion undergoing thrombectomy. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - October 3, 2018 Category: Neurology Authors: Wenchen Li, Shang Wang, Shijun Li, Xin Chen, Yunyun Xiong Source Type: research

Clinical Outcome of Ischemic Stroke in Old Patients Versus Oldest-Old
Background: It is unclear whether very old patients benefit from stroke unit. The aim of our work was to compare the clinical outcome of patients with ischemic stroke aged either 70 or 80 (G 1) versus oldest-old greater than or equal to 81years (G 2). Methods: Of 1187 patients admitted with stroke during 5 years in our stroke unit, we included 252 patients with independent functional status (modified Rankin scale, [mRS] ≤ 2) before the stroke. All patients underwent clinical examination, blood test, electrocardiography, brain imaging, and cerebrovascular ultrasound. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - September 29, 2018 Category: Neurology Authors: Dolores Cocho, Sulema Yarleque, Anuncia Boltes, Jordi Espinosa, Jordi Ciurans, Claustre Pont-Sunyer, Jordi Pons Source Type: research

Effective Reserve: A Latent Variable to Improve Outcome Prediction in Stroke
Prediction of functional outcome after stroke based on initial presentation remains an open challenge, suggesting that an important aspect is missing from these prediction models. There exists the notion of a protective mechanism called brain reserve, which may be utilized to understand variations in disease outcome. In this work, we expand the concept of brain reserve (effective reserve) to improve prediction models of functional outcome after acute ischemic stroke (AIS). Consecutive AIS patients with acute brain magnetic resonance imaging ( (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - September 28, 2018 Category: Neurology Authors: Markus D. Schirmer, Mark R. Etherton, MD, PhD, Adrian V. Dalca, PhD, Anne-Katrin Giese, MD, Lisa Cloonan, MSc, Ona Wu, PhD, Polina Golland, PhD, Natalia S. Rost, MD, MPH, FAAN Source Type: research