Association between electrocardiographic and echocardiographic atrial abnormalities and prognosis in cryptogenic stroke
The role of atrial fibrillation in cryptogenic stroke (CS) is well known. However, the usefulness of left atrial (LA) electrical and morphological abnormalities to identify more disabling strokes in sinus rhythm patients is less studied. We evaluated the association between electrocardiographic P-wave abnormalities and echocardiographic LA measures with neurological disability in patients with cryptogenic stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 15, 2020 Category: Neurology Authors: Eduardo Gatti Pianca, Luiz Gustavo Bravosi da Rosa, Pedro Tregnago Barcellos, Sheila Cristina Ouriques Martins, Murilo Foppa, Maur ício Pimentel, Angela Barreto Santiago Santos Source Type: research

Dysphagia and disability in minor strokes – An institutional study
Ischemic strokes can be mild and non-disabling in around two third patients at onset.1 This is one of the major reason for delay in seeking medical attention, non-administration of thrombolytic therapy, incomplete evaluation and non-urgent initiation of secondary preventive strategies. Risk of early recurrence of neurological events is around 12%, with roughly half of them occurring in the first 48  h of onset.2 These strokes are not always associated with excellent outcome with short term disability ranging between 19% and 35% across various studies. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 15, 2020 Category: Neurology Authors: Sapna Erat Sreedharan, Jaffar Vali Sayed, V P Vipina, Manju P Mohan, Rejith Paul, PN Sylaja Source Type: research

Chinese medicine Tongxinluo capsule protects against blood-brain barrier disruption after ischemic stroke by inhibiting the low-density lipoprotein receptor-related protein 1 pathway in mice
In this study, we explored whether TXL could downregulate LRP-1 expression and subsequently protect against BBB disruption after stroke using permanent middle cerebral artery occlusion (pMCAO) in mice. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 15, 2020 Category: Neurology Authors: Liping Chang, Li Hu, Cong Wei, Hui Zhang, Shen Liu Source Type: research

Interactive effect of susceptibility-diffusion mismatch and recanalization status on clinical outcome in large vessel occlusion stroke
Objective: To investigate the interactive effect of susceptibility-diffusion mismatch and recanalization status on clinical outcome in patients with acute ischemic stroke due to large vessel occlusion.Methods: In this prospective study, consecutive ischemic stroke patients admitted within 24 h from symptom onset underwent emergency multimodal MRI at admission, including diffusion-weighted imaging (DWI), susceptibility-weighted imaging (SWI), and time-of-flight magnetic resonance angiography (TOF-MRA). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 15, 2020 Category: Neurology Authors: Haifei Jiang, Yiqun Zhang, Jiangxia Pang, Han-Cheng Qiu, Ao-Fei Liu, Chen Li, Ji Zhou, Min Jin, Fengyuan Man, Wei-Jian Jiang Source Type: research

Comparative analysis of fibrinolytic properties of Alteplase, Tenecteplase and Urokinase in an in vitro clot model of intracerebral haemorrhage
Hematoma lysis with recombinant tissue plasminogen activator (rtPA) has emerged as an alternative therapy for spontaneous intracerebral and intraventricular haemorrhage (ICH and IVH). However, the MISTIE III and CLEAR III trial failed to show significant improvement of favourable outcomes. Besides experimental and clinical trials revealed neurotoxic effects of rtPA. The demand for optimization of fibrinolytic therapy persists. Herein, we used our recently devised clot model of ICH to systematically analyse fibrinolytic properties of rtPA, tenecteplase and urokinase. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 15, 2020 Category: Neurology Authors: Naureen Keric, Melanie D öbel, Harald Krenzlin, Elena Kurz, Yasemin Tanyildizi, Axel Heimann, Jochem König, Oliver Kempski, Florian Ringel, Julia Masomi-Bornwassser Source Type: research

The role of microstructural integrity of major language pathways in narrative speech in the first year after stroke
Stroke is one of the most common acquired neurological disorders and the leading cause of disability, and one-third of stroke survivors suffer from varying degrees of aphasia.1-2 Post-stroke aphasia is a complex disorder that arises from heterogeneous pathologies in large convoluted networks in the brain;3-5 thus, revealing its natural progression and recovery patterns remains difficult.6 However, understanding post-stroke aphasia recovery patterns is equally crucial to individualize treatment intensity and strategies, as many diverse language deficits may persist. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 15, 2020 Category: Neurology Authors: Zafer Keser, Erin L. Meier, Melissa D. Stockbridge, Argye E. Hillis Source Type: research

Anterior circulation large vessel occlusion stroke in Saudi Arabia: Prevalence, predictors, and outcome
Anterior circulation Large Vessel Occlusion (LVO) stroke comes with significant morbidity and mortality. With the advent of endovascular interventions, its management has revolutionized. For health authorities to build systems and allocate resources, its burden, predictors, and outcome must be determined. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 15, 2020 Category: Neurology Authors: Ali M. Al Khathaami, Mohammed A. Aldriweesh, Bayan A. Al Bdah, Muath A. Alhasson, Sultan A. Alsaif, Waleed A. Alluhidan, Faisal M. Almutairi, Mohammed A. Alskaini, Nasser Alotaibi, Saeed A.M. Alghamdi Source Type: research

Detection of impaired cerebrovascular reactivity in patients with chronic cerebral ischemia using whole-brain 7T MRA
We examined whether whole-brain magnetic resonance angiography (MRA) at 7T could non-invasively detect impaired CVR in patients with chronic cerebral ischemia by demonstrating the leptomeningeal collaterals (LMCs). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 15, 2020 Category: Neurology Authors: Ikuko Uwano, Hiroyuki Kameda, Taisuke Harada, Masakazu Kobayashi, Wataru Yanagihara, Kengo Setta, Kuniaki Ogasawara, Kunihiro Yoshioka, Fumio Yamashita, Futoshi Mori, Tsuyoshi Matsuda, Makoto Sasaki Source Type: research

Predictors and prognoses of new onset post-stroke anxiety at one year in black Africans
There is relatively limited information on the risk factors and outcome of new onset Poststroke Anxiety (PSA) in Low- and Middle-Income Countries. We estimated incidence, cumulative incidence, risk factors and outcome of new onset anxiety in the first year of stroke among African stroke survivors. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 15, 2020 Category: Neurology Authors: Akin Ojagbemi, Joshua Akinyemi, Mayowa Owolabi, Rufus Akinyemi, Oyedunni Arulogun, Mulugeta Gebregziabher, Onoja Akpa, Olanrewaju Olaniyan, Babatunde Salako, Bruce Ovbiagele Source Type: research

Is smoking a risk factor for bleeding in adult men with cerebral arteriovenous malformations? A single-center regression study from China
To assess whether smoking increases the risk of bleeding in patients with cerebral arteriovenous malformations (CAVM). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 15, 2020 Category: Neurology Authors: Shuai Zhang, Chenguang Zhou, Dong Liu, Yongjun Piao, Fuqiang Zhang, Jie Hu, Zongqian Ma, Zhanyang Wei, Weisheng Zhu, Ming Lv Source Type: research

Progressive thrombosis of cervical and intracranial arteries related to Ponatinib treatment for Chronic Myeloid Leukemia
Ponatinib is a third-generation Tyrosine Kinase Inhibitor (TKI), approved as first-line treatment for Chronic Myeloid Leukaemia (CML) chronic phase.Here we describe a CML patient with a history of subsequent TIAs and an ischemic stroke during Ponatinib treatment. Patient was admitted for a 3-day history of sudden onset left hemiparesis due to an acute ischemic stroke. MRI showed bilaterally the almost total absence of signal in the intracranial tract of anterior circulation and low signal of cerebral posterior circulation. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 15, 2020 Category: Neurology Authors: E Spina, R Renna, LA Lanterna, ML Colleoni, V Andreone Tags: Case Report Source Type: research

Electrocardiographic left atrial abnormality in patients presenting with ischemic stroke
P wave indices represent electrocardiographic marker of left atrial pathology. We hypothesized that P wave would be more abnormal in patients presenting with ischemic stroke than a comparable group without ischemic stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 15, 2020 Category: Neurology Authors: Younghoon Kwon, Stephen McHugh, Kayvon Ghoreshi, Genevieve R Lyons, Yeilim Cho, Kenneth C. Bilchick, Sula Mazimba, Bradford B. Worrall, Nazem Akoum, Lin Y Chen, Elsayed Z. Soliman Source Type: research

Sex differences of ischemic stroke in young adults —A single-center Chinese cohort study
Stroke at a young age is a societal challenge with a rising incidence. Our aim was to investigate sex differences in risk factors, etiology, and diagnostic process of ischemic stroke in Chinese young adults. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 15, 2020 Category: Neurology Authors: Mingyu Tang, Ming Yao, Yicheng Zhu, Bin Peng, Lixin Zhou, Jun Ni Source Type: research

Endovascular treatment of acute carotid atherosclerotic tandem occlusions: Predictors of clinical outcomes as technical aspects and location of tandem occlusions
We aimed to analyze angiographic and clinical outcomes according to the sequence of treatment (antegrade versus retrograde) in patients with acute ischemic stroke caused by tandem extracranial cervical carotid and intracranial large vessel occlusion. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 15, 2020 Category: Neurology Authors: Jung-Soo Park, Jong-Myong Lee, Hyo-Sung Kwak, Gyung Ho Chung Source Type: research

Prevalence of stroke-related sarcopenia: A systematic review and meta-analysis
Objectives: Although the skeletal muscle is the main effector of disability in stroke, evidence on post-stroke skeletal muscle is scarce; especially, the prevalence of stroke-related sarcopenia remains unclear. Thus, we aimed to systematically search the prevalence of sarcopenia in stroke survivors and synthesize pooled estimates of overall prevalence of stroke-related sarcopenia and prevalence stratified by sex, country, time since stroke onset, and diagnostic criteria of sarcopenia. Methods: We performed systematic searches in the MEDLINE, CINAHL, Embase, and Cochrane Library databases. (Source: Journal of Stroke and Cer...
Source: Journal of Stroke and Cerebrovascular Diseases - August 15, 2020 Category: Neurology Authors: Ya Su, Michiko Yuki, Mika Otsuki Source Type: research

Routine use of FLAIR-negative MRI in the treatment of unknown onset stroke
Treatment of FLAIR-negative stroke in patients presenting in an unknown time window has been shown to be safe and effective. However, implementation can be challenging due to the need for hyper-acute MRI screening. The purpose of this study was to review the routine application of this practice outside of a clinical trial. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 15, 2020 Category: Neurology Authors: Malik M. Adil, Marie Luby, John K. Lynch, Amie W. Hsia, Chandni P. Kalaria, Zurab Nadareishvili, Lawrence L. Latour, Richard Leigh Source Type: research

Dashcam-captured moment of right hemispheric stroke
We reported the first case dashcam-captured images at the first sign of a right hemispheric stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 15, 2020 Category: Neurology Authors: Haruna Miyazawa, Yasuo Terayama Tags: Case Report Source Type: research

Masthead
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 15, 2020 Category: Neurology Source Type: research

Editorial Board
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 15, 2020 Category: Neurology Source Type: research

Table of Contents
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 15, 2020 Category: Neurology Source Type: research

Decrease in Pulse Wave Velocity is Associated with Clinical Improvement in Patients with Ischemic Stroke
Arterial stiffness is an independent determinant of cardiovascular and cerebrovascular risks. The relationship between the increase in arterial stiffness parameters and the severity of stroke has been shown in previous studies. We aimed to investigate the association between clinical improvement and changes in arterial stiffness parameters in patients presenting acute ischemic stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 15, 2020 Category: Neurology Authors: Ay şegül Demir, Şerefnur Öztürk, Ahmet Hakan Ekmekçi, Kenan Demir, Ahmet Avcı, Fettah Eren, Mesut Sivri Source Type: research

Brachial-Ankle Pulse Wave Velocity is Related to the Total Cerebral Small-Vessel Disease Score in an Apparently Healthy Asymptomatic Population
Cerebral small-vessel disease (CSVD) is an extensive cerebrovascular disease that mainly involves the perforating arterioles, capillaries and venules and plays a crucial role in stroke and dementia.1 Due to the inability of conventional noninvasive angiography to display small cerebral vessels, relevant brain parenchymal lesions on brain magnetic resonance imaging (MRI) can be used as an alternative marker for CSVD. These markers include recent small subcortical infarcts, lacunes of presumed vascular origin, white matter hyperintensity (WMH) of presumed vascular origin, perivascular space (PVS), cerebral microbleeds (CMBs)...
Source: Journal of Stroke and Cerebrovascular Diseases - August 15, 2020 Category: Neurology Authors: Tiantian Liu, Yuanyuan Liu, Shuhua Wang, Xiaolong Du, Zhaofeng Zheng, Ning Wang, Xunyao Hou, Chao Shen, Jian Chen, Xueping Liu Source Type: research

A Prehospital Acute Stroke Trial has Only Modest Impact on Enrollment in Concurrent, Post-arrival-Recruiting Stroke Trials
Because “time is brain,” acute stroke trials are migrating to the prehospital setting. The impact upon enrollment in post-arrival trials of earlier recruitment in a prehospital trial requires delineation. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 14, 2020 Category: Neurology Authors: Phoebe Johnson-Black, Gregory Wong, Sidney Starkman, Nerses Sanossian, Latisha Sharma, May Kim-Tenser, David Liebeskind, Lucas Restrepo-Jimenez, Miguel Valdes-Sueiras, Samuel Stratton, Marc Eckstein, Frank Pratt, Robin Conwit, Scott Hamilton, Judy Guzy, I Source Type: research

Subarachnoid Hemorrhage Caused by Ruptured Aneurysm of the Artery of Adamkiewicz: a Case Report
A 66-year-old man presented with a 6-day history of progressive posterior cervical pain that included lower back pain and fever. Neurological examinations revealed neck stiffness. Computed tomography demonstrated convexity subarachnoid hemorrhage. A spinal T2-weighted image revealed a hypointense signal lesion with contrast enhancement of the intradural extramedullary space at Th12 –L1. Digital subtraction angiography showed a fusiform aneurysm with a 10 mm diameter in the artery of Adamkiewicz. We diagnosed the patient's condition as a ruptured aneurysm of the artery of Adamkiewicz. (Source: Journal of Stroke a...
Source: Journal of Stroke and Cerebrovascular Diseases - August 14, 2020 Category: Neurology Authors: Takashi Nakamura, Tatsuya Ueno, Akira Arai, Masatoshi Iwamura, Hiroshi Midorikawa, Kensuke Murakami, Masahiko Tomiyama Tags: Case Report Source Type: research

Ipsilateral Nonstenotic Carotid Disease in Minor Ischemic Stroke: an Exploratory Analysis of The POINT Randomized Clinical Trial
Dual antiplatelet therapy, with combination aspirin and clopidogrel, is now standard of care in the secondary prevention of minor stroke and transient ischemic attack1 –3 as well as stroke due to intracranial atherosclerotic disease.4 However, in the Clopidogrel in High-risk patients with Acute Nondisabling Cerebrovascular Events (CHANCE)2 and Platelet Oriented Inhibition in New TIA and Minor Ischemic Stroke (POINT)3 randomized clinical trials, determination of the etiology of ischemic stroke was not required to initiate secondary prevention. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 13, 2020 Category: Neurology Authors: Zachary Bulwa, Faddi G. Saleh Velez, James R. Brorson, Camila B. Pinto Source Type: research

Safety of Mechanical Thrombectomy with Combined Intravenous Thrombolysis in Stroke Treatment 4.5 to 9 Hours from Symptom Onset
An extended time window for intravenous thrombolysis (IVT) for acute stroke patients up to 9 hours from symptom onset has been established in recent trials, excluding patients who received mechanical thrombectomy (MT). We therefore investigated whether combined therapy with IVT and MT (IVT+MT) is safe in patients with ischemic stroke and large vessel occlusion (LVO) in an extended time window. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 13, 2020 Category: Neurology Authors: Tilman Reiff, Oliver Barthel, Peter Arthur Ringleb, Johannes Pfaff, Sibu Mundiyanapurath Source Type: research

Therapeutic Effects of Iron Chelation in Atorvastatin-Induced Intracranial Hemorrhage of Zebrafish Larvae
Intracranial hemorrhage (ICH) acutely and severely damages brain function.1,2 The prognosis of ICH is poor due to the drastic and rapid progression of its pathology, and the lack of effective treatments presents a significant unmet clinical need. Therefore, novel therapeutic agents for ICH have the potential to significantly improve clinical outcomes. The collagenase-induced rodent ICH model is the most commonly used experimental ICH model.3 However, detailed live imaging of hematoma development in rodent models is inherently limited, as rodents are opaque. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 13, 2020 Category: Neurology Authors: Shinsuke Nakamura, Yuichi Saito, Takumi Gouda, Takahiko Imai, Masamitsu Shimazawa, Yuhei Nishimura, Hideaki Hara Source Type: research

Convexity Subarachnoid Hemorrhage Soon after Starting a Direct Oral Anticoagulant in 2 Patients with Acute Infarction
Convexity subarachnoid hemorrhage (cSAH) is typically due to head trauma, but various nontraumatic causes for cSAH are known also. Nontraumatic cSAH is most commonly associated with cerebral amyloid angiopathy (CAA) in the elderly or with reversible cerebral vasoconstriction syndrome in younger subjects,1 but cSAH rarely occurs subsequent to acute ischemic stroke.2 Direct oral anticoagulants (DOACs) are used to reduce the risk of ischemic stroke and systemic embolism in patients with non-valvular atrial fibrillation and have favorable bleeding profiles as compared with warfarin,3,4 but here we describe 2 cSAH patients who ...
Source: Journal of Stroke and Cerebrovascular Diseases - August 13, 2020 Category: Neurology Authors: Yoichiro Sugita, Yoichiro Nishida, Satoru Ishibashi, Takanori Yokota Tags: Case Report Source Type: research

Remote Ischemic Post-Conditioning may Improve Post-Stroke Cognitive Impairment: A Pilot Single Center Randomized Controlled Trial
We aimed to demonstrate the tolerability and feasibility and the effect of remote ischemic post-conditioning on cognitive functioning in patients with post-stroke cognitive impairment. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 13, 2020 Category: Neurology Authors: Yue-juan li, Ke-Ke Liang, Long Zhang, Rui Pan, Ya-mei Hu, Jian-hua Zhao Source Type: research

The Effect of a County Prehospital FAST-ED Initiative on Endovascular Treatment Times
Stroke is the fifth leading cause of death in the United States, with approximately 140,000 deaths per year, and a cost of $34 billion per year.1 The most severe strokes are caused by large vessel occlusions (LVOs) which benefit the most from timely endovascular thrombectomy. In the US this therapy is reliably available only at thrombectomy-capable and comprehensive stroke centers (TSCs and CSCs, respectively).2 It is therefore important that patients with LVO stroke are identified promptly as such and triaged appropriately to the right facility type. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 13, 2020 Category: Neurology Authors: Helen Rynor, Jake Levine, Joseph Souchak, Ned Shashoua, Maygret Ramirez, Ivis C. Gonzalez, Virginia Ramos, Anshul Saxena, Emir Veledar, Amy K. Starosciak, Felipe De Los Rios La Rosa Source Type: research

Lysophosphatidic acid increased infarct size in the early stage of cerebral ischemia-reperfusion with increased BBB permeability
Maintaining the integrity of blood-brain barrier (BBB) is one of the most important factors for brain homeostasis and cell survival during cerebral ischemic-reperfusion. Decreasing BBB disruption has been associated with better neuronal outcome in cerebral ischemia-reperfusion.1 –3 It is critical to find agents or regimen that can decrease the degree of the BBB disruption associated with cerebral ischemia especially during the very early stage of reperfusion. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 11, 2020 Category: Neurology Authors: Oak Z. Chi, Scott J. Mellender, Geza K. Kiss, Antonio Chiricolo, Xia Liu, Nikhil Patel, Estela Jacinto, Harvey R. Weiss Source Type: research

Adherence to study drug in a stroke prevention trial"? >
Standards for reporting and analyzing adherence to medical therapy have recently improved due to international consensus efforts. If applied to clinical trial research in patients with stroke, these improvements have the potential to identify when in the sequence of trial operations participants are at risk for non-adherence and opportunities to safeguard adherence. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 11, 2020 Category: Neurology Authors: Akshatha Kiran, Catherine M. Viscoli, Karen L. Furie, Mark Gorman, Walter N. Kernan Source Type: research

Mechanisms of early Recurrence in Intracranial Atherosclerotic Disease (MyRIAD): Rationale and design
Intracranial atherosclerotic disease (ICAD) is the most common cause of ischemic stroke with the highest rate of recurrence, despite aggressive medical management. Diverse mechanisms may be responsible for ICAD-related cerebral ischemia, with potential therapeutic implications. Here we present the rationale, design and methods of the Mechanisms of Early Recurrence in Intracranial Atherosclerotic Disease (MyRIAD) study. The aim of MyRIAD is to determine the mechanisms of stroke in ICAD through physiologic imaging biomarkers that evaluate impaired antegrade flow, poor distal perfusion, abnormal vasoreactivity, artery to arte...
Source: Journal of Stroke and Cerebrovascular Diseases - August 11, 2020 Category: Neurology Authors: David S Liebeskind, Shyam Prabhakaran, Nizam Azhar, Edward Feldmann, Iszet Campo-Bustillo, Rajbeer Sangha, Sebastian Koch, Tatjana Rundek, Lauren Ostergren, Marc I. Chimowitz, Jose G. Romano, MyRIAD Investigators Source Type: research

Benefits and Safety of Periprocedural Heparin During Thrombectomy in Patients Contra-Indicated for Alteplase
Role of peri-procedural heparin as an adjuvant treatment during mechanical thrombectomy (MT) for patients contra-indicated for alteplase remains a source of debate. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 11, 2020 Category: Neurology Authors: Sol ène Hebert, Pierre Clavel, Benjamin Maier, Katsuhiro Mizutani, François Delvoye, Bertrand Lapergue, Malek Ben Maacha, Robert Fahed, Simon Escalard, Jean-Philippe Desilles, Hocine Redjem, Gabriele Ciccio, Stanislas Smajda, Raphael Blanc, Michel Pioti Source Type: research

Asymmetry of medullary veins on multiphase CT-angiography in patients with acute ischemic stroke
The management of acute ischemic stroke (AIS) has rapidly evolved over the last decade with the advancement in neuroimaging selection methods and endovascular treatment techniques. CT perfusion (CTP) with automated post-processing is the most widely used technique for extended-time window selection of patients for intra-arterial interventions based on recent clinical trials.1,2 CTP provides predictive information about stroke outcome, however the predictive ability remains moderate with area under the curve (AUC) approximately 0.6. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 11, 2020 Category: Neurology Authors: A.A. Drozdov, R. Javan, C.R. Leon Guerrero, A.D. Sparks, M.R. Taheri Source Type: research

Predictors of Futile Recanalization After Endovascular Treatment in Patients with Acute Ischemic Stroke in a Multicenter Registry Study
Early recanalization of the occluded vessel by endovascular treatment (EVT) has been proven to be a powerful predictor of favorable outcome for patients with acute ischemic stroke (AIS) in the anterior circulation.1-5 However, a remarkable proportion of patients – even with successful recanalization – still develop adverse outcomes, such as futile recanalization (FR). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 11, 2020 Category: Neurology Authors: Haifeng Xu, Baixue Jia, Xiaochuan Huo, Dapeng Mo, Ning Ma, Feng Gao, Ming Yang, Zhongrong Miao Source Type: research

Hemorrhagic stroke associated with essential thrombocythemia: Case report and literature review
Essential thrombocythemia (ET) is a chronic myeloproliferative neoplasm characterized by the overproduction of circulating platelets in the peripheral blood, caused by the excessive proliferation of megakaryocytes in the bone marrow.1 Cerebrovascular events, mainly ischemic stroke, are one of the most serious complications in patients with ET, and the V617F mutation in the Janus kinase 2 (JAK2) gene is recognized as a thrombotic risk factor.2 Hemorrhagic stroke associated with ET is very infrequent, and the effect of mutation types on hemorrhagic stroke remains unclear. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 11, 2020 Category: Neurology Authors: Akihiko Momozaki, Jun Masuoka, Takashi Furukawa, Motofumi Koguchi, Hiroshi Ito, Fumitaka Yoshioka, Kohei Inoue, Atsushi Ogata, Yukiko Nakahara, Tatsuya Abe Tags: Case Report Source Type: research

Management for a patient of moyamoya disease presenting with ischemic stroke in the first trimester of pregnancy
We report an extremely rare case of a 27-year-old woman presenting with ischemic stroke as an initial manifestation of moyamoya disease in the first trimester of pregnancy. We conducted an artificial abortion when her neurological symptoms rapidly became refractory to optimal antithrombotic treatments. The progression of neurologic deficits stopped immediately after abortion, resulting in recovery to independence, with slight motor aphasia and right hemiparesis due to improved cerebral flow. We highlight rapid artificial abortion combined with antithrombotic treatment for patients of moyamoya disease with pregnancy-associa...
Source: Journal of Stroke and Cerebrovascular Diseases - August 11, 2020 Category: Neurology Authors: Masashi Watanabe, Kanehisa Kohno, Tomoki Shinohara, Toshimoto Seno, Satoshi Fujiwara, Shinji Onoue, Shinya Fukumoto, Haruhisa Ichikawa, Shinji Iwata, Kensho Okamoto, Shiro Ohue Tags: Case Report Source Type: research

Mild cognitive impairment and receipt of procedures for acute ischemic stroke in older adults
Older patients with pre-existing mild cognitive impairment (MCI) receive less evidence-based care after acute myocardial infarction, however, whether they receive less care after acute ischemic stroke (AIS) is unknown. We compared receipt of guideline-concordant procedures after AIS between older adults with pre-existing MCI and normal cognition. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 11, 2020 Category: Neurology Authors: Deborah A. Levine, Andrzej Galecki, Mohammed Kabeto, Brahmajee K. Nallamothu, Darin B. Zahuranec, Lewis B. Morgenstern, Lynda D. Lisabeth, Bruno Giordani, Kenneth M. Langa Source Type: research

Stroke literacy in the population of the Eastern Province of Saudi Arabia; immediate steps are essential to bridge the gap
Stroke is one of the core non-communicable diseases (NCDs), which is preventable and demands appropriate preventive measures for reducing disease burden.1 Stroke has become the major challenge to health care system in Saudi Arabia (SA). According to the World Health Organization (WHO), stroke was the second commonest cause of death after coronary artery disease with deaths reaching 11, 409, or 11.7% of total deaths. The age adjusted deaths rate was 89.82 per 100,000 population.2 A recently published study reported an incidence rate for the first-time ever stroke as 57.64 per 100,000 person-years. (Source: Journal of Stroke...
Source: Journal of Stroke and Cerebrovascular Diseases - August 11, 2020 Category: Neurology Authors: Azra Zafar, Aishah Ibrahim Albakr, Rizwana Shahid, Saima Nazish, Danah Aljaafari, Fahd Ali Alkhamis, Ahmed Abdulfattah Aldajani, Amir H. Msmar, Ismail A. Khatri Source Type: research

Mechanical thrombectomy in patients with proximal occlusions and low NIHSS: Results from a large prospective registry
Mechanical thrombectomy is now standard of care for treatment of acute ischemic stroke secondary to large vessel occlusion in the setting of high NIHSS. We analysed a large nationwide registry focusing on patients with large vessel occlusion and low NIHSS on admission to evaluate the efficacy and safety of thrombectomy in this patient population (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 11, 2020 Category: Neurology Authors: Leonardo Renieri, Valentina Saia, Vitor Mendes Pereira, Giovanni Pracucci, Nicola Limbucci, Sergio Nappini, Pascal N Tyrrell, Francesco Arba, Patrizia Nencini, Domenico Inzitari, Andrea Giorgianni, Massimiliano Natrella, Roberto Menozzi, Umberto Scoditti, Source Type: research

Unusual manifestation of heat stroke: Isolated trochlear nerve palsy
Heat stroke is a life-threatening disease characterized by hyperthermia and neurological dysfunction. The central nervous system is highly sensitive to hyperthermia, which causes neurological complications due to the involvement of the cerebellum, basal ganglia, anterior horn cells, and peripheral nerves. Several studies reported about clinical symptoms and brain image findings of heat stroke. Isolated cranial nerve dysfunction caused by lacunar infarction is an extremely rare condition in patient with heat stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 11, 2020 Category: Neurology Authors: Sanghoon Han, Baik-kyun Kim, Kyu Sun Yum Tags: Case report Source Type: research

Weekend Effect on in-Hospital Mortality for Ischemic and Hemorrhagic Stroke in US Rural and Urban Hospitals
Previous studies have reported a “weekend effect” on stroke mortality, whereby stroke patients admitted during weekends have a higher risk of in-hospital death than those admitted during weekdays. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 11, 2020 Category: Neurology Authors: Birook Mekonnen, Guijing Wang, Janani Rajbhandari-Thapa, Lu Shi, Kiran Thapa, Zheng Zhang, Donglan Zhang Source Type: research

Therapeutic Effects of Diagonal-Transcranial Direct Current Stimulation on Functional Recovery in Acute Stroke: A Pilot Study
The amount of spontaneous motor recovery of the paretic upper extremity in stroke is relatively fixed, and accounts for approximately 70% of maximal potential recovery within the first 6 months after stroke onset.1,2 Peak neurologic recovery from stroke occurs within the first 3 months, and continues at a slower pace for at least 6 months.3 Therefore, the effects of early training at 1 –2 weeks after stroke onset exceeds the effects of delayed training in terms of functional recovery in both animals and humans,4–6 and initiating rehabilitative training 5 or more days after stroke is mostly beneficial and has no...
Source: Journal of Stroke and Cerebrovascular Diseases - August 11, 2020 Category: Neurology Authors: Takashi Shibata, Akio Urata, Kazuyuki Kawahara, Kota Furuya, Koji Ishikuro, Noriaki Hattori, Satoshi Kuroda Source Type: research

Predictors and Consequences of Silent Brain Infarction in Patients with Asymptomatic Carotid Stenosis
Silent brain infarction (SBI) is associated with an increased risk of stroke in patients with asymptomatic carotid stenosis (ACS), and is therefore one of the criteria for performing carotid endarterectomy (CEA). Despite an extensive literature, this issue is still a matter of debate. Aim of the present work was to evaluate incidence and predictors of SBI in patients undergoing CEA for ACS, and to investigate its possible impact on CEA outcome. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 11, 2020 Category: Neurology Authors: Rodolfo Pini, Gianluca Faggioli, Giuseppe Indelicato, Sergio Palermo, Andrea Vacirca, Enrico Gallitto, Chiara Mascoli, Mauro Gargiulo Source Type: research

High-concentration homocysteine inhibits mitochondrial respiration function and production of reactive oxygen species in neuron cells
Homocysteine (Hcy) is an essential intermediate for the metabolism of two other sulfur-containing amino acid in the human body; derived from methionine, Hcy can form methionine through remethylation, and through transsulfuration it forms cystathionine, which is further lysed to generate cysteine.1,2 Cys and Hcy play critical roles in cellular redox homeostasis3,4 and other processes, so it is essential to maintain an appropriate level of Hcy under normal physiological conditions.2 Abundant studies have been carried out to extensively investigate the role of Hcy in various human diseases in the past two decades since the di...
Source: Journal of Stroke and Cerebrovascular Diseases - August 11, 2020 Category: Neurology Authors: Tao Zhang, Dengliang Huang, Jing Hou, Jianhua Li, Yaogang Zhang, Meiyuan Tian, Zhiqin Li, Tingting Tie, Yan Cheng, Xiaoming Su, Zhu Man, Yanyan Ma Source Type: research

Stroke Mimics: A five-year follow-up study from the Qatar Stroke Database
Mimics comprise a third of patients presenting with an acute stroke. There is limited information on their natural history. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 11, 2020 Category: Neurology Authors: Naveed Akhtar, Zain Bhutta, Saadat Kamran, Blessy Babu, Namitha Jose, Sujatha Joseph, Deborah Morgan, Reny Francis, Ahmed Own, Ashfaq Shuaib Source Type: research

Cerebral Microhemorrhage and Purpuric Rash in COVID-19: The Case for a Secondary Microangiopathy
We report the case of a COVID-19 patient with diffuse microhemorrhages on brain MRI, positive anticardiolipin antibodies, and purpuric rash with biopsy showing a thrombotic vasculopathy, all features suggestive of secondary microangiopathy. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 11, 2020 Category: Neurology Authors: Aaron Shoskes, Ibrahim Migdady, Anthony Fernandez, Paul Ruggieri, Alexander Rae-Grant Tags: Case Report Source Type: research

Association between out-of-bed mobilization and complications of immobility in acute phase of severe stroke: A retrospective observational study
Medical complications often occur, particularly in the acute phase of severe stroke, and lead to poor outcomes. However, it is unclear whether out-of-bed mobilization (OM) reduces such complications or not in the acute phase of severe stroke. Thus, we investigated the association between OM and complications of immobility in the acute phase of severe stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 11, 2020 Category: Neurology Authors: Yoshinori Naito, Masataka Kamiya, Naohito Morishima, Tomoji Ishikawa Source Type: research

The Occurrence Rate of Swallowing Disorders After Stroke Patients in Asia: A PRISMA-Compliant Systematic Review and Meta-Analysis
Swallowing disorders (dysphagia) is common in stroke patients. However, the epidemiology of post-stroke dysphagia (PSD) is poorly described. We herein synthesize the data of eligible studies on occurrence rate of dysphagia in Asian populations with stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 11, 2020 Category: Neurology Authors: Ping-ping Meng, Shu-chao Zhang, Chao Han, Qiang Wang, Guang-tao Bai, Shou-wei Yue Source Type: research