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Angiographic demonstration of a cutoff sign as an unfavorable prognostic indicator for patients with acute ischemic stroke undergoing mechanical thrombectomy
The aim was to investigate whether the angiographic demonstration of a cutoff sign on the initial angiogram could predict recanalization and prognosis in acute ischemic stroke patients treated by endovascular thrombectomy. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - March 4, 2024 Category: Neurology Authors: Wei Zhang, Wei Zhang, Tongtong Liu, Dayong Shen, Qingyun Li Source Type: research

Advances in Neurovascular Research: Scientific Highlights from the 2024 International Stroke Conference
The 2024 annual International Stroke Conference (ISC), one of the largest meetings dedicated to the science, prognosis, and treatment of cerebrovascular diseases and brain health, took place in Phoenix, Arizona, United States, between February 7-9, 2024. In the following sections, we summarize the salient aspects of the most relevant studies presented at the 2024 ISC. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - March 3, 2024 Category: Neurology Authors: Joseph R. Geraghty, Fernando D. Testai Source Type: research

MicroRNA-7 Attenuates Secondary Brain Injury Following Experimental Intracerebral Hemorrhage via Inhibition of NLRP3
Intracerebral hemorrhage (ICH), a prevalent condition in neurosurgery, constitutes approximately 10-15% of all stroke types. Its global annual incidence surpasses 200 million cases, and the associated high disability and mortality rates pose substantial burdens on families and society.1 Presently, the mechanisms driving brain damage in ICH remain incompletely deciphered, and adequate medical interventions to enhance patient prognosis are yet to be established. Mechanisms of brain tissue damage following ICH include hematoma mass effect, excitotoxicity, oxidative stress, and inflammatory reactions. (Source: Journal of Strok...
Source: Journal of Stroke and Cerebrovascular Diseases - March 2, 2024 Category: Neurology Authors: Bo Luo, Lin Li, Xu-Dong Song, Hua-Xuan Chen, De-Bo Yun, Lin Wang, Yuan Zhang Source Type: research

Unveiling the Evolving Landscape of Stroke Care Costs: A Time-Driven Analysis
In this study, we aim to calculate the annual cumulative and per-patient cost of stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - February 29, 2024 Category: Neurology Authors: Bill Hum, Kamil Taneja, Sean Bunachita, Hadi Ashor, Jeeyong Shin, Anshel Bright, Ryan Wang, Karan Patel Source Type: research

Medium-intensity statin with ezetimibe versus high-intensity statin in acute ischemic cerebrovascular disease (MESIA):a randomized clinical trial
Compared to guideline-recommended high-intensity statin therapy, moderate-intensity statin with ezetimibe further improved the achievement rate of LDL-C in patients with acute ischemic cerebrovascular disease, with a higher reduction magnitude in LDL-C. In terms of safety, there was no significant difference between the two regimens, suggesting that moderate-intensity statin with ezetimibe can also be considered as an initial treatment option for patients with acute ischemic cerebrovascular disease. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - February 28, 2024 Category: Neurology Authors: Xuxian Lv, Xudong Liu, Yanfang Peng, Wenbin Li, Jianing Wang, Xiaofeng Chen, Junjie Lei, Chaogang Tang, Shijian Luo, Weihua Mai, Yiming Cai, Qian Fan, Liu Chenhao, Lei Zhang Source Type: research

Comparison of atrial septal defect and patent foramen ovale in cryptogenic strokes
Paradoxical embolism from right-to-left shunt through atrial septal defect (ASD) and patent foramen ovale (PFO) is a well-accepted cause of “cryptogenic” strokes (CS). To better understand the pathogenic role of ASD, we compared ASD patients with CS having a high and low likelihood of being PFO-related. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - February 28, 2024 Category: Neurology Authors: Constant Delabays, Pamela Correia, Eric Eeckhout, Alain Delabays, Patrik Michel Source Type: research

Blood biomarkers for post-stroke cognitive impairment: a systematic review and meta-analysis
Post-stroke cognitive impairment (PSCI) is a frequent consequence of stroke, which affects the quality of life and prognosis of stroke survivors. Numerous studies have indicated that blood biomarkers may be the key determinants for predicting and diagnosing cognitive impairment, but the results remain varied. Therefore, this meta-analysis aims to summarize potential biomarkers associated with PSCI. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - February 27, 2024 Category: Neurology Authors: Yuxia Ma, Yanru Chen, Tingting Yang, Xiang He, Yifang Yang, Junbo Chen, Lin Han Source Type: research

Dysregulated SYVN1 promotes CAV1 protein ubiquitination and accentuates ischemic stroke
Stroke is the leading cause of disability and the second leading cause of death worldwide, and the incidence of stroke is increasing as the global population ages 1. It can be further categorized into ischemic stroke (IS) during which there is first a reversible loss of tissue function due to an inadequate supply of blood to cerebral tissue and infarction with loss of neurons and supportive structures as progresses, and hemorrhagic stroke 2, 3. There remains a significant need for developing therapeutic agents for neuroprotection in IS to protect the brain from damage before and during recanalization, extend the time windo...
Source: Journal of Stroke and Cerebrovascular Diseases - February 27, 2024 Category: Neurology Authors: Chunjie Gu, Yang Liu, Xiuli An, Gang Yin, Chenghe Sun Source Type: research

Velvet antler polypeptide (VAP) protects against cerebral ischemic injury through NF- κB signaling pathway in vitro
Velvet antler polypeptide (VAP) has been shown to play important roles in the immune and nervous systems. The purpose of this study was to investigate the protective effects of VAP on cerebral ischemic injury with the involvement of NF- κB signaling pathway in vitro. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - February 26, 2024 Category: Neurology Authors: Qian Wu, Yutao Li, Ru Ye, Hui Wang, Ying Ge Source Type: research

Delirium in acute stroke is associated with increased cognitive and psychiatric symptoms over time: The Nor-COAST study
Globally, the lifetime risk of stroke is approximately 25%1. Recent advances in acute stroke care have improved mortality rates and short-term functional outcomes remarkably2. However, long-term cognitive impairment and psychiatric symptoms are still common causes of disability after stroke3-5, and further improvements in stroke care may have a valuable impact. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - February 26, 2024 Category: Neurology Authors: Elise Gjestad, Vilde Nerdal, Ingvild Saltvedt, Stian Lydersen, Elisabeth Kliem, Truls Ryum, Ramune Grambaite Source Type: research

Impact of Early MRI in Ischemic Strokes Beyond Hyper-acute Stage to Improve Patient Outcomes, Enable Early Discharge, and Realize Cost Savings
Ischemic stroke (IS) is a devastating disease1 that has profound consequences for patients and their families.2 Computed tomography (CT) is the preferred imaging modality during the hyper-acute stage (time up to the point of initiating reperfusion therapies) for diagnosing IS and treatment decision-making regarding thrombolysis and EVT due to its accessibility and rapid image acquisition. However, magnetic resonance imaging (MRI) remains to be crucial beyond this early stage. Similar to many centers globally, current study center utilizes a multimodal CT-based approach during the hyper-acute stage, while MRI is typically u...
Source: Journal of Stroke and Cerebrovascular Diseases - February 26, 2024 Category: Neurology Authors: Mukesh Kumar, Steven Beyea, Sherry Hu, Noreen Kamal Source Type: research

Trends in Stroke-Related Journals: Examination of Publication Patterns Using Topic Modeling
This study aims to demonstrate the capacity of natural language processing and topic modeling to manage and interpret the vast quantities of scholarly publications in the landscape of stroke research. These tools can expedite the literature review process, reveal hidden themes, and track rising research areas. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - February 25, 2024 Category: Neurology Authors: Burak Berksu Ozkara, Mert Karabacak, Konstantinos Margetis, Wade Smith, Max Wintermark, Vivek Srikar Yedavalli Source Type: research

Registration Study for the Prevention and Treatment of Cerebral Hemorrhage using Naoxueshu Oral Liquid: Protocol for a Research Study
: Naoxueshu oral liquid is the only approved drug for acute treatment of cerebral hemorrhage in China. It has been used widely for the treatment of acute ischemic stroke and acute hemorrhagic stroke. However, safety and efficacy data on the early use of Naoxueshu oral liquid are lacking. The main purpose of this study is to observe the benefit and safety of early use of Naoxueshu oral liquid ( (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - February 25, 2024 Category: Neurology Authors: Kexin Wang, Yuanyuan Chen, Qingwen Geng, Jinjuan Dou, Dahe Qi, Weidong Zhu, Lianying Song, Jingpei Wei, Mengmeng Ding, Yunlong Hao, Lingbo Kong, Ying Gao Source Type: research

Trends in Cerebral Venous Thrombosis Before and During the COVID-19 Pandemic: Analysis of the National Inpatient Sample
We sought to provide updated incidence and trend data for cerebral venous thrombosis (CVT) in the United States from 2016-2020, examine the impact of the COVID-19 pandemic on CVT, and identify predictors of in-hospital mortality. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - February 24, 2024 Category: Neurology Authors: Piers Klein, Liqi Shu, Muhammad M. Qureshi, Mohamad Abdalkader, Thalia S. Field, James E. Siegler, Lily W. Zhou, Karan Patel, Sami Al Kasab, Adam de Havenon, Shadi Yaghi, Adnan I. Qureshi, Thanh N. Nguyen Source Type: research

Intravenous thrombolysis for ischemic stroke in the posterior circulation: A systematic review and meta-analysis.
Intravenous thrombolysis (IVT) is recommended in patients with ischemic stroke in the anterior and posterior circulation. Neurological outcomes due to posterior circulation strokes (PCS) without treatment remain poor. Our aim was to overview the literature on outcomes of IVT and conservative treatment in PCS, based on a systematic review and meta-analysis. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - February 21, 2024 Category: Neurology Authors: Robrecht R.M.M. Knapen, Senta Frol, Sander M.J. van Kuijk, Janja Pretnar Oblak, Christiaan van der Leij, Robert J. van Oostenbrugge, Wim H van Zwam Source Type: research