Effect of Robot Assisted Gait Training on Motor and Walking Function in Patients with Subacute Stroke: A Random Controlled Study
Robot-assisted gait training has been confirmed to have beneficial effect on the rehabilitation of stroke patients. An exoskeleton robot, named BEAR-H1, is designed to help stroke patients with walking disabilities. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 22, 2021 Category: Neurology Authors: Dong-Xia Li, Fu-Bing Zha, Jian-Jun Long, Fang Liu, Jia Cao, Yu-Long Wang Source Type: research

Effects of a Soft Robotic Hand for Hand Rehabilitation in Chronic Stroke Survivors
Soft robotic hands are proposed for stroke rehabilitation in terms of their high compliance and low inherent stiffness. We investigated the clinical efficacy of a soft robotic hand that could actively flex and extend the fingers in chronic stroke subjects with different levels of spasticity. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 22, 2021 Category: Neurology Authors: Xiang Qian Shi, Ho Lam Heung, Zhi Qiang Tang, Zheng Li, Kai Yu Tong Source Type: research

Re: Prognosis of Neurological Improvement in Inpatient Acute Ischemic Stroke Survivors: A Propensity Score Matching Snalysis
Wu Q and colleagues1 conducted a propensity-score (PS) matched study to identify prediction factors associated with short-term outcomes in patients with acute ischemic stroke survivors (improvement/ no improvement). In an effort to control for confounding, the authors matched on the propensity score to balance the National Institute of Health Stroke Scale (NIHSS) at admission between the two outcome groups. After matching, 92 pairs were analyzed in a multivariable outcome model of which two variables, diabetes and cognitive assessment, were identified as independent risk factors for the prognosis of neurological improvemen...
Source: Journal of Stroke and Cerebrovascular Diseases - April 22, 2021 Category: Neurology Authors: Rania A Mekary, Jiping Zhou, Tobias Kurth Tags: Letter to the Editor Source Type: research

Incidence of Neo-Intimal Hyperplasia in Anterior Circulation Aneurysms Following Pipeline Flow Diversion
We present our experience with flow diversion of the distal vasculature and evaluate the incidence of neo-intimal hyperplasia. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 20, 2021 Category: Neurology Authors: Jared B. Cooper, Jacob D. Greisman, Katarina Dakay, Gurmeen Kaur, Fawaz Al-Mufti, Chirag D. Gandhi, Justin G. Santarelli Source Type: research

The Effect of Sham Controlled Continuous Theta Burst Stimulation and Low Frequency Repetitive Transcranial Magnetic Stimulation on Upper Extremity Spasticity and Functional Recovery in Chronic Ischemic Stroke Patients
This randomized controlled study examined the effect of continuous theta burst stimulation (cTBS) and low frequency repetitive transcranial magnetic stimulation (rTMS) on upper extremity spasticity and functional recovery in chronic ischemic stroke patients. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 20, 2021 Category: Neurology Authors: Ömer Kuzu, Emre Adiguzel, Serdar Kesikburun, Evren Yaşar, Bilge Yılmaz Source Type: research

Dystypia Associated with Diaschisis of the Middle Frontal Gyri after Left Angular Infarction
Dystypia without aphasia, agraphia, or apraxia is a rare symptom and has been suggested to result from a lesion in the left middle frontal cortex. We herein describe a man with dystypia with agraphia due to infarction of the left angular gyrus. His dystypia seemed to result from the convergence failure of the kana into the alphabetical spellings. During dystypia, hypoperfusion of the bilateral middle frontal cortices was discovered. However, after his symptoms improved, blood flow in the middle frontal cortices returned to normal. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 20, 2021 Category: Neurology Authors: Kengo Maeda, Yutaka Yamamoto, Tomoyuki Shiraishi, Eriko Fujioka Tags: Case Report Source Type: research

A Machine Learning Approach to First Pass Reperfusion in Mechanical Thrombectomy: Prediction and Feature Analysis
Novel machine learning (ML) methods are being investigated across medicine for their predictive capabilities while boasting increased adaptability and generalizability. In our study, we compare logistic regression with machine learning for feature importance analysis and prediction in first-pass reperfusion. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 19, 2021 Category: Neurology Authors: Lohit Velagapudi, Nikolaos Mouchtouris, Richard F. Schmidt, David Vuong, Omaditya Khanna, Ahmad Sweid, Bryan Sadler, Fadi Al Saiegh, M. Reid Gooch, Pascal Jabbour, Robert H. Rosenwasser, Stavropoula Tjoumakaris Source Type: research

Authors ’ Reply to: Do All Gliflozins Reduce Stroke in Patients with Type 2 Diabetes Mellitus and Impaired Renal Function?
Zhao LM et al. kindly comment on the design and the results of our recently published meta-analysis.1,2 (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 19, 2021 Category: Neurology Authors: Fotios Barkas, Evangelos Liberopoulos, Haralampos Milionis Source Type: research

Positive Association Between Serum Insulin-Like Growth Factor-1 and Cognition in Patients with Cerebral Small Vessel Disease
Cognitive impairment is one of the main complications of cerebral small vessel disease (CSVD). Serum insulin-like growth factor-1 (IGF-1) might serve as a marker for the risk of cognitive decline in patients with CSVD. We investigated the association of IGF-1 with the development of cognitive impairment in patients with CSVD. We included 216 patients with CVSD (mean age, 67.57  ± 8.53 years; 31.9% female). We compared 117 (54.2%) patients who developed cognitive impairment with 99 (45.8%) patients without cognitive impairment. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 17, 2021 Category: Neurology Authors: Jingwen Kang, Wenqiu Luo, Cuiwei Zhang, Yi Ren, Liping Cao, Jian Wu, Huajie Li Source Type: research

Alberta Stroke Program Early CT Score Calculation Using the Deep Learning-Based Brain Hemisphere Comparison Algorithm
The Alberta Stroke Program Early Computed Tomography Score (ASPECTS) is a promising tool for the evaluation of stroke expansion to determine suitability for reperfusion therapy. The aim of this study was to validate deep learning-based ASPECTS calculation software that utilizes a three-dimensional fully convolutional network-based brain hemisphere comparison algorithm (3D-BHCA). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 17, 2021 Category: Neurology Authors: Masaki Naganuma, Atsushi Tachibana, Takuya Fuchigami, Sadato Akahori, Shuichiro Okumura, Kenichiro Yi, Yoshimasa Matsuo, Koichi Ikeno, Toshiro Yonehara Source Type: research

Quantitative collateral assessment evaluated by cerebral blood volume measured by CT perfusion in patients with acute ischemic stroke
The variability in the pre-existing collateral status (CS) is considered an independent determinant of clinical outcomes for patients with acute ischemic stroke (AIS).1,2 Among patients with acute anterior circulation large-vessel occlusion (LVO), those with a highly developed CS have a large area of salvageable brain tissue and respond well to reperfusion therapy (RT).1,3 Therefore, the evaluation of CS is essential in the selection of optimal candidates who would benefit from RT. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 17, 2021 Category: Neurology Authors: Sakyo Hirai, Yoji Tanaka, Hirotaka Sato, Koichi Kato, Yongson Kim, Toshihiro Yamamura, Kazutaka Sumita, Toshinari Arai Source Type: research

De Novo Dural Arteriovenous Fistula on Draining Veins of Previously Treated Pial Arteriovenous Malformation: a Case Report.
A 71-year-old man, with a pial micro-arteriovenous malformation (pAVM) draining into the confluence of the vein of Trolard and the vein of Labb é was surgically removed, sparing these cortical veins. 4-months MR and angiographic controls showed a de novo dural arteriovenous fistula (dAVF) draining into the previously spared cortical veins. It was removed using intraoperative motor evoked potentials (MEP). This is the first case of iatrogen ic dAVF developing on the same draining vein of a previously treated pAVM. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 17, 2021 Category: Neurology Authors: Francesco Diana, Luigino Tosatto, Nicol ò Haznedari, Christian Commodaro, Maria Ruggiero Tags: Case Report Source Type: research

Pre-Hospital Diagnosis in Mobile Stroke Unit
Mobile stroke unit (MSU) has been shown to rapidly provide pre-hospital thrombolysis in acute ischemic stroke (AIS). MSU encounters neurological disorders other than AIS that require emergent treatment. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 17, 2021 Category: Neurology Authors: Ramnath Santosh Ramanathan, Dolora Wisco, Daniel Vela-Duarte, Atif Zafar, Ather Taqui, Stacey Winners, A Blake Buletko, Fredrick Hustey, Andrew Reimer, Andrew Russman, Ken Uchino, M Shazam Hussain Source Type: research

Do all gliflozins reduce stroke in patients with type 2 diabetes mellitus and impaired renal function?
We have read with great interest a study of meta-analysis1 recently published in Journal of Stroke and Cerebrovascular Diseases. In that study1 Barkas and colleagues drew their main conclusion that sodium-glucose transporter 2 (SGLT2) inhibitors reduce the risk of total stroke in patients with type 2 diabetes mellitus (T2DM) and impaired renal function (IRF), which was based on the result of meta-analysis on the outcome of total stroke (including ischemic and hemorrhagic stroke) in the subgroup of patients with T2DM and IRF (Fig. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 17, 2021 Category: Neurology Authors: Li-Min Zhao, Liang-Liang Ding, Ze-Lin Zhan, Mei Qiu Tags: Letter to the Editor Source Type: research

Liver Fibrosis is Associated with Ischemic Stroke Risk in Women but not Men: The REGARDS Study
Nonalcoholic fatty liver disease is inconsistently associated with ischemic stroke, with one study suggesting an association in women and not men. The relative importance of liver fibrosis, as opposed to fatty liver, for cardiovascular risk is increasingly appreciated. We hypothesized that advanced liver fibrosis is associated with incident ischemic stroke risk, and especially in women. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 16, 2021 Category: Neurology Authors: Neal S. Parikh, Insu Koh, Lisa B. VanWagner, Mitchell S.V. Elkind, Neil A. Zakai, Mary Cushman Source Type: research

Use of Pulmonary Computed Tomography for Evaluating Suspected Stroke-Associated Pneumonia
Accurate and timely diagnosis of pneumonia complicating stroke remains challenging and the diagnostic accuracy of chest X-ray (CXR) in the setting of stroke-associated pneumonia (SAP) is uncertain. The overall objective of this study was to evaluate the use of pulmonary computed tomography (CT) in diagnosis of suspected SAP. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 16, 2021 Category: Neurology Authors: Amit K. Kishore, Anand Devaraj, Andy Vail, Kirsty Ward, Philip G. Thomas, Dwaipayan Sen, Alex Procter, Maychaw Win, Natasha James, Christine Roffe, Andreas Meisel, Mark Woodhead, Craig J. Smith Source Type: research

Duplicated Middle Cerebral Artery Aneurysms Treated by Coil Embolization; A Report of Two Cases and Literature Review
Duplication of the middle cerebral artery (DMCA) is an anomalous vessel arising from the internal carotid artery (ICA). Aneurysms at the origin of a DMCA have been reported; however, most have been treated with clipping surgery. Here, we describe two cases of aneurysms at the origin of a DMCA treated with coil embolization. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 15, 2021 Category: Neurology Authors: Kenta Fujimoto, Hiroyuki Hashimoto, Yoshitomo Uchiyama, Hidetsugu Maekawa, Yoichi Shida, Ichiro Nakagawa Tags: Case Report Source Type: research

“Unusual Pattern of Cerebral Microbleeds and Petechial Hemorrhages after Veno-Arterial Extracorporeal Membrane Oxygenation Support. A Report of 2 Cases”
Intracerebral hemorrhages (ICH) are the most frequent neurological complications, with an incidence estimated of 5% in adults under veno-venous (VV) and veno-arterial extracorporeal membrane oxygenation (VA-ECMO).1 (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 15, 2021 Category: Neurology Authors: Monique Boukobza, Carsten Ehmer, Fr édéric Baud, Jean-Pierre Laissy Tags: Case Report Source Type: research

An Enriched Environment Leads to Increased Synaptic Plasticity-Associated miRNA Levels after Experimental Subarachnoid Hemorrhage
Subarachnoid hemorrhage is a type of stroke caused by usually bleeding in the subarachnoid space with high morbidity and mortality.1,2 The cause is usually arterial aneurysm rupture and arterial hypertension. SAH also affects cognitive functions. Half of the patients may return to their daily lives in a year after SAH, but most of these patients often have problems in memory, executive functions, and speech functions in the future.3 Although long-term neurological disorders are thought to be caused by late-term cerebral ischemia due to vasospasm triggered by extravascular blood contact with the arteries, the molecular basi...
Source: Journal of Stroke and Cerebrovascular Diseases - April 15, 2021 Category: Neurology Authors: Fulya Buge Ergen, Didem Turgut Cosan, Turan Kandemir, İlknur Dag, Fezan Mutlu, Tevfik Erhan Cosan Source Type: research

Long-Term Outcomes of Stroke or Transient Ischemic Attack after Non-Emergency Percutaneous Coronary Intervention
Elective percutaneous coronary intervention is increasing in volume, which may be due to an increased use of CT coronary angiography as a first-line investigation for the evaluation of chest pain.1,2 Stroke is a debilitating neurological complication with increasing incidence after PCI in recent years, due to an increasing complexity of patients.3 Large observational and randomized controlled studies found that peri-procedural stroke occurred in 0.13-0.4% of unselected patients who underwent PCI. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 14, 2021 Category: Neurology Authors: Jamie SY Ho, Ching-Hui Sia, Andie Hartanto Djohan, Rodney Yu-Hang Soh, Benjamin YQ Tan, Leonard LL Yeo, Hui-Wen Sim, Tiong-Cheng Yeo, Huay-Cheem Tan, Mark Yan-Yee Chan, Joshua Ping-Yun Loh Source Type: research

Inflammatory Bowel Disease as a Precondition for Stroke or TIA: A Matter of Crohn's Disease Rather than Ulcerative Colitis
As a chronic systemic inflammation may be associated with an increased risk of vascular events, the aim of the present study was to assess the incidence of stroke and transient ischemic attack (TIA) in patients with inflammatory bowel disease over a period of 15 years. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 14, 2021 Category: Neurology Authors: Christian Tanislav, Kathleen Trommer, Christian Labenz, Karel Kostev Source Type: research

Intravenous tPA Delays Door-To-Puncture Time in Acute Ischemic Stroke with Large Vessel Occlusion
Although intravenous thrombolysis (IVT) is recommended among acute ischemic stroke (AIS) patients secondary to large vessel occlusion (LVO) undergoing mechanical thrombectomy (MT), time delays with bridging therapy (IVT prior to MT) and its potential benefit remains unclear. We compared the time delays and clinical outcomes among AIS SECONDARY TO LVO patients treated with bridging therapy or direct MT (dMT) at a comprehensive stroke center (CSC). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 14, 2021 Category: Neurology Authors: Kunakorn Atchaneeyasakul, Shashvat Desai, Konark Malhotra, Jaydevsinh Dolia, Kavit Shah, Jeffrey L. Saver, Tudor Jovin, Ashutosh P. Jadhav Source Type: research

Clinical and Demographic Factors Influence Clinical Trial Enrollment
Clinical trial screening is a key siphon point in the clinical research pipeline, with biases in this step potentially informing treatment indications, medication outcomes, and overall generalizability of data to a population at large.1 Addressing clinical trial enrollment is a crucial step towards equity in medicine.2,3 Enrollment biases have been identified in stroke clinical trials previously, including enrolling larger strokes with higher NIHSS scores in Endovascular trials, underrepresentation of women, and missing NIHSS documentation in stroke registries. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 14, 2021 Category: Neurology Authors: Daniel J. Suto, Emily Perrinez, Karen S. Rapp, Mohammed Nabulsi, Thomas M. Hemmen Source Type: research

Failure of Anticoagulation to Prevent Stroke in Context of Lupus-Associated Anti-Phospholipid Syndrome and Mild COVID-19
We present a 43-year-old female with a history of seropositive-antiphospholipid syndrome and systemic lupus erythematosus who developed an acute ischemic stroke in the setting of mild COVID-19 infection despite adherence to chronic systemic anticoagulation. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 12, 2021 Category: Neurology Authors: Keith J. Kincaid, Alexis N. Simpkins Source Type: research

COVID-19 Associated Reversible Cerebral Vasoconstriction Syndrome Successfully Treated with Nimodipine and Aspirin
A 31-year-old sexually active, non-smoker female with a past medical history of spina-bifida and idiopathic thoracolumbar scoliosis status post hardware spinal fusion surgery five years ago presented with a one-day history of severe holocranial headaches associated with nausea and visual changes. A thorough neurological examination was intact. She complained of mild cough as well. She had a positive nasopharyngeal swab for SARS-CoV-2 on RT-PCR assay. A comprehensive drug screen including amphetamines, cocaine, nicotine, alcohol, and ecstasy as well as a pregnancy test were negative; coagulation profile was within normal li...
Source: Journal of Stroke and Cerebrovascular Diseases - April 12, 2021 Category: Neurology Authors: Tarab Mansoor, Ali A. Alsarah, Hossein Mousavi, Javed Elyias, Tarun Girotra, Omar Hussein Tags: Case Report Source Type: research

Detection of Myocardial Infarction by Cardiac Magnetic Resonance in Embolic Stroke Related to First Diagnosed Atrial Fibrillation
Elevated troponin levels are found in a significant number of patients who are diagnosed with acute embolic stroke (AES) after first diagnosed atrial fibrillation (AF). These myocardial injuries, which are known as cardiocerebral infarction (CCI), are potentially caused by coronary embolism and correspond to simultaneous cardiac and cerebral embolisms. However, this severe condition remains poorly understood. In this prospective study, we aimed to investigate the prevalence and the cardiac magnetic resonance (CMR) characteristics of CCI. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 10, 2021 Category: Neurology Authors: Adrien Artus, Romain Didier, Margaux Blain, Pierre Comby, Thibault Leclercq, Hugo Debeaumarch é, Frédéric Ricolfi, Marianne Zeller, Yannick Bejot, Alexandre Cochet, Yves Cottin Source Type: research

Constraint Induced Movement Therapy Increases Functionality and Quality of Life after Stroke
The paretic and spastic brachial condition causes the learned non-use, also known as disuse; the individual expresses difficulty in using the compromised upper limb and develops compensatory mechanisms that prioritize the use of only the unaffected extremity, triggering the poor adaptation of neuroplasticity, which is the ability to recover a nerve function through behavior change strategies.25,35 (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 10, 2021 Category: Neurology Authors: Larissa Salgado Oliveira Rocha, Geisa Crissy Bandeira Gama, Rodrigo Santiago Barbosa Rocha, Let ícia de Barros Rocha, Caroline Prudente Dias, Luciane Lobato Sobral Santos, Márcio Clementino de Souza Santos, Maria Imaculada de Lima Montebelo, Rosana Mach Source Type: research

Small Interfering RNA Targeting DMP1 Protects Mice Against Blood-Brain Barrier Disruption and Brain Injury After Intracerebral Hemorrhage
This study aimed to investigate the expression pattern of DMP1 in the mouse brain and explore the role of DMP1 in BBB disruption and brain injury in a mouse model of ICH. Mice were subjected to autologous blood injection-induced ICH. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 9, 2021 Category: Neurology Authors: Yue Shu, Juan Huang, Meng Gao, Shengwei Gan, Shujuan Zhu, Shiye Xu, Zhengyu Yang, Yuhui Liao, Weitian Lu Source Type: research

Falls After Stroke: A Follow-up after Ten Years in Lund Stroke Register
To evaluate incidence of self-reported falls and associated factors in a ten-year perspective after stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 8, 2021 Category: Neurology Authors: Ann-Cathrin J önsson, Ingrid Lindgren, Hossein Delavaran, Bo Norrving, Arne Lindgren Source Type: research

Changes in Procoagulant Blood Biomarkers After Mechanical Thrombectomy
We report changes in blood coagulation markers after MT treated with and without tissue plasminogen activator for AIS. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 8, 2021 Category: Neurology Authors: Jonathan C. Welch, Kadir Erkmen, Nina Gentile Source Type: research

Endovascular Treatment of Infective Endocarditis-Related Acute Large Vessel Occlusion Stroke
Embolic stroke is a frequent complication of infective endocarditis yet lacks acute treatment as intravenous thrombolysis should be avoided due to high risk of intracerebral hemorrhage. Mechanical thrombectomy for large vessel occlusion may be a promising treatment but there is limited data on safety outcomes in infective endocarditis. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 8, 2021 Category: Neurology Authors: Elie Sader, Mohamad Abdalkader, Natalie Thom, Thanh N. Nguyen, Sandra McDonald, David Greer, Stacy C. Brown, Alaa Mohamedali, Jose Gutierrez, Hang Shi, Jane Morris, Victor Lopez-Rivera, Sunil A. Sheth, Kelly L. Sloane, Aneesh Singhal, Kunakorn Atchaneeyas Source Type: research

Inversion of T Waves on Admission is Associated with Mortality in Spontaneous Intracerebral Hemorrhage
Cardiac dysfunction directly caused by spontaneous intracerebral hemorrhage (ICH) is a poorly understood phenomenon, and its impact on outcome is still uncertain. The aim of this study is to investigate the relationship between electrocardiographic (EKG) abnormalities and mortality in ICH. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 8, 2021 Category: Neurology Authors: Andrea Loggini, Ali Mansour, Faten El Ammar, Ruth Tangonan, Christopher L. Kramer, Fernando D. Goldenberg, Christos Lazaridis Source Type: research

Effect of Rhythm of Music Therapy on Gait in Patients with Stroke: Several Questions
This study is a valuable and interesting article but we have several queries about this article. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 8, 2021 Category: Neurology Authors: Lei Chen, Lan Chen, Weina Tang Tags: Letter to the Editor Source Type: research

Telestroke Across the Continuum of Care: Lessons from the COVID-19 Pandemic
While use of telemedicine to guide emergent treatment of ischemic stroke is well established, the COVID-19 pandemic motivated the rapid expansion of care via telemedicine to provide consistent care while reducing patient and provider exposure and preserving personal protective equipment. Temporary changes in re-imbursement, inclusion of home office and patient home environments, and increased access to telehealth technologies by patients, health care staff and health care facilities were key to provide an environment for creative and consistent high-quality stroke care. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 8, 2021 Category: Neurology Authors: Amy K. Guzik, Sheryl Martin-Schild, Prasanna Tadi, Sherita N. Chapman, Sami Al Kasab, Sharyl R. Martini, Brett C. Meyer, Bart M. Demaerschalk, Marcella A. Wozniak, Andrew M. Southerland Source Type: research

Masthead
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 7, 2021 Category: Neurology Source Type: research

Editorial Board
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 7, 2021 Category: Neurology Source Type: research

Table of Contents
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 7, 2021 Category: Neurology Source Type: research

Mean Platelet Volume is a Prognostic Marker in Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis
There is conflicting data regarding the association between platelet parameters and prognosis of stroke patients treated with intravenous thrombolysis. We aimed to analyze this association in a cohort of patients treated with rtPA. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 7, 2021 Category: Neurology Authors: Filipa Dourado Sotero, Alexandre Cal çada, Diana Aguiar de Sousa, Mariana Dias, Ana Catarina Fonseca, Teresa Pinho e Melo, Patrícia Canhão Source Type: research

Dietary Oily Fish Intake is Inversely Associated with Severity of White Matter Hyperintensities of Presumed Vascular Origin. A Population-Based Study in Frequent Fish Consumers of Amerindian Ancestry
Oily fish is a major dietary source of omega-3 polyunsaturated fatty acids and other nutrients that may reduce the expression of cerebral small vessel disease (cSVD) biomarkers, including white matter hyperintensities (WMH) of presumed vascular origin. However, information on this relationship is limited. We aimed to assess the association between oily fish intake and WMH severity in a population of frequent fish consumers. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 7, 2021 Category: Neurology Authors: Oscar H. Del Brutto, Bettsy Y. Recalde, Robertino M. Mera Source Type: research

Outcomes of COVID-19 complications and their possibilities as potential triggers of stroke
The coronavirus disease 2019 (COVID-19) has been a pandemic like no other seen in our times. It has impacted the entire globe affecting more than 180 countries with 81.9 million cases and 1.7 million deaths as of December 29, 20201. Unlike other virus-related spread, COVID-19 since its early days is known to have a high infection rate as well as high mortality, which in turn has resulted in such a devastating impact across the world. The mortality rates among hospitalized patients with COVID-19 infection without stroke range from 22% to 45%2,3, but the mortality was very high (38%) in stroke patients with COVID-19 infectio...
Source: Journal of Stroke and Cerebrovascular Diseases - April 7, 2021 Category: Neurology Authors: Urvish Patel, Preeti Malik, Deep Mehta, Priyanka Rajput, Mashu Shrivastava, Madiha Naveed, Eseosa Urhoghide, Mehwish Martin, Shamima Somi, Richa Jaiswal, Achint Patel, Avantika Israni, Jagmeet Singh, Asim Kichloo, Shamik Shah, Abhishek Lunagariya Source Type: research

International survey of Mechanical Thrombectomy Stroke systems of care during COVID-19 pandemic
The COVID-19 pandemic has strained the healthcare systems across the world but its impact on acute stroke care is just being elucidated. We hypothesized a major global impact of COVID-19 not only on stroke volumes but also on various aspects of thrombectomy systems. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 6, 2021 Category: Neurology Authors: Dileep R Yavagal, Vasu Saini, Violiza Inoa, Hannah E Gardener, Sheila O Martins, Manav Fakey, Santiago Ortega, Ossama Mansour, Thomas Leung, Ashutosh P Jadhav, Jennifer Potter-Vig, Anurag Mairal, Miao Zhongrong, P.N. Sylaja, Andrew M Demchuk, MT2020 Globa Source Type: research

Wall Redness of Enlarged Unruptured Cerebral Aneurysm
This study aimed to evaluate the EUCA wall redness based on quantitative signal intensity method and to compare the clinical and radiological characteristics between EUCA and non-EUCA. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 5, 2021 Category: Neurology Authors: Hidetoshi Matsukawa, Yoichiro Nagao, Manabu Shirakawa, Kazutaka Uchida, Shinichi Yoshimura Source Type: research

White Matter Hyperintensity and Cardiovascular Disease Outcomes in the SPRINT MIND Trial
The Systolic Blood Pressure Intervention Trial (SPRINT) randomized patients to a goal systolic blood pressure (SBP) (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 3, 2021 Category: Neurology Authors: Nazanin Sheibani, Ka-Ho Wong, Tanya N. Turan, Sharon D. Yeatts, Rebecca F. Gottesman, Shyam Prabhakaran, Natalia S. Rost, Adam de Havenon Source Type: research

Safety of Ticagrelor in Moderate and Severe Acute Ischemic Stroke: A Single-Center Retrospective Review
Ticagrelor is a potent P2Y12 receptor antagonist that may have a role in acute ischemic stroke (AIS), particularly in patients with symptomatic atherosclerotic disease.1,2 Recently, a large randomized control trial demonstrated a significant reduction in stroke or death within 30 days following minor stroke or TIA with ticagrelor plus aspirin versus aspirin alone.3 Studies of ticagrelor have focused on patients with minor stroke or TIA; however, safety of ticagrelor following more severe ischemic strokes is unknown. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 3, 2021 Category: Neurology Authors: Stephen W. English, David R. Landzberg, Nirav R. Bhatt, Michael R. Frankel, Digvijaya Navalkele Source Type: research

Consideration Needed for early Anticoagulation Following Intravenous tPA in Patients with COVID-19
We read the article by Carneiro et al with great interest.1 We have similar experiences at two downtown Los Angeles certified stroke centers with the use of intravenous tPA. However, there are concerning observations lately among COVID-19 patients who developed large vessel re-occlusions shortly after their original stroke symptoms were aborted by intravenous tPA. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 2, 2021 Category: Neurology Authors: Angelo Jimenez, Arvind Ravinutala, Jonathan Eskenazi, Prissilla Xu, Antonio Liu Tags: Letter to the Editor Source Type: research

Letter to Editor: Consideration Needed for Early Anticoagulation Following Intravenous tPA in Patients with COVID-19
We read the article by Carneiro et al with great interest1. We have similar experiences at two downtown Los Angeles certified stroke centers with the use of intravenous tPA. However, there are concerning observations lately among COVID-19 patients who developed large vessel re-occlusions shortly after their original stroke symptoms were aborted by intravenous tPA. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 2, 2021 Category: Neurology Authors: Angelo Jimenez, Arvind Ravinutala, Jonathan Eskenazi, Prissilla Xu, Antonio Liu Source Type: research

Ischemic Cerebellar Stroke in a 4-Year-Old Boy After Chickenpox: An Atypical Vascular Involvement
We describe a pediatric case of post-varicella cerebellar stroke due to basilar artery involvement. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 1, 2021 Category: Neurology Authors: Patr ícia Marques, Cristina Pereira, Fernando Silva, Teresa Garcia, Joana A. Ribeiro Tags: Case Report Source Type: research

Clinical and Genetic Heterogeneity in a Large Family with Pseudoxanthoma Elasticum: MTHFR and SERPINE1 Variants as Possible Disease Modifiers in Developing Ischemic Stroke
Pseudoxanthoma elasticum (PXE) is a rare autosomal recessive disorder caused by pathogenic variants in the ABCC6 gene. The phenotypic spectrum of PXE is highly variable and includes principally three major features: skin lesions, eye and vascular manifestations, while brain manifestations are less common. To date about 400 different PXE associated variants in ABCC6 gene are described without any evident genotype –phenotype correlation. Herein, we report the clinical and molecular findings of a large PXE family with clinical and genetic intra-familial variability with significant cerebrovascular involvement. (Source: ...
Source: Journal of Stroke and Cerebrovascular Diseases - April 1, 2021 Category: Neurology Authors: Giorgia Bruno, Marco Ritelli, Andrea Di Pietro, Lorenzo Cipriano, Marina Colombi, Giacomo Lus, Gianfranco Puoti Source Type: research

“Eye” Don't See: An Analysis of Visual Symptom Reporting by Stroke Survivors from a Large Epidemiology Study
The purpose was to explore the reported symptoms of post-stroke visual impairment from a large multi-centre prospective epidemiology study. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 1, 2021 Category: Neurology Authors: Lauren R Hepworth, Claire Howard, Kerry L Hanna, Jim Currie, Fiona J Rowe Source Type: research

Study Protocol for a Randomized, Double-Blind, Placebo-Controlled, Phase-II Trial: AdrenoMedullin for Ischemic Stroke Study
Acute ischemic stroke (IS) is a devastating disorder closely linking to severe disabilities and poor quality of life. Currently, the only approved treatments are antiplatelet agents and reperfusion therapies; identifying other therapeutic options is necessary and urgent.1 After the onset of blood vessel occlusion, ischemic injury triggers inflammatory cascades in the parenchyma that further amplify tissue damage,2,3 implying the necessity of anti-inflammatory treatment from the very acute phase of IS. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 1, 2021 Category: Neurology Authors: Takeshi Yoshimoto, Satoshi Saito, Katsuhiro Omae, Yorito Hattori, Kazuki Fukuma, Kazuo Kitamura, Ryosuke Kakuta, Toshihiro Kita, Hirofumi Maruyama, Haruko Yamamoto, Masafumi Ihara Source Type: research