Differential Impact of Index Stroke on Dementia Risk in African-Americans Compared to Whites
To compare whites and African-Americans in terms of dementia risk following index stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 1, 2018 Category: Neurology Authors: D.G. Clark, A.D. Boan, C. Sims-Robinson, R.J. Adams, E.J. Amella, A. Benitez, D.T. Lackland, B. Ovbiagele Source Type: research

The Genetic Landscape of Cerebral Steno-Occlusive Arteriopathy and Stroke in Sickle Cell Anemia
Sickle cell disease (SCD) is one of the most common autosomal recessive diseases in humans, occurring at a frequency of 1 in 365 African-American and 1 in 50 sub-Saharan African births. Despite progress in managing complications of SCD, these remain a major health burden worldwide. Stroke is a common and serious complication of SCD, most often associated with steno-occlusive cerebral arteriopathy, but little is known about its pathogenesis. Transcranial Doppler ultrasonography is currently the only predictive test for future development of stroke in patients with sickle cell anemia and is used to guide preventative treatme...
Source: Journal of Stroke and Cerebrovascular Diseases - August 1, 2018 Category: Neurology Authors: Catherine Amlie-Lefond, Jonathan Flanagan, Julie Kanter, William B. Dobyns Tags: Review Article Source Type: research

Fixed Dose IV rt-PA and Clinical Outcome in Ischemic Stroke Patients With Body Weight > 100 kg: Pooled Data From 3 Randomized Clinical Trials
The ASA/AHA guidelines recommend a fixed dose of 90 mg of intravenous (IV) recombinant tissue plasminogen activator (rt-PA) for acute stroke patients weighing more than 100 kg. We aimed to determine if body weight>100 kg (and receiving (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 1, 2018 Category: Neurology Authors: Shahram Majidi, Christopher R. Leon Guerrero, Kathleen M. Burger, Dimitri Sigounas, Wayne J. Olan, Adnan I. Qureshi Source Type: research

Comprehensive Rehabilitation Training Decreases Cognitive Impairment, Anxiety, and Depression in Poststroke Patients: A Randomized, Controlled Study
To explore the effect of comprehensive rehabilitation training (CRT) on cognitive impairment, anxiety, and depression in poststroke patients. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 30, 2018 Category: Neurology Authors: Chunmei Cheng, Xin Liu, Wenjun Fan, Xue Bai, Zhaojun Liu Source Type: research

Associations of Diffusion-Tensor Fractional Anisotropy and FIM Outcome Assessments After Intracerebral Hemorrhage
This study aimed to clarify the associations between fiber tract degeneration evaluated by diffusion-tensor imaging (DTI) and outcomes following intracerebral hemorrhage (ICH). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 30, 2018 Category: Neurology Authors: Tetsuo Koyama, Yuki Uchiyama, Kazuhisa Domen Source Type: research

Effects of Repetitive Facilitative Exercise on Spasticity in the Upper Paretic Limb After Subacute Stroke
Repetitive facilitative exercise is an effective method for recovery of the affected limb in stroke patients. However, its effects on spasticity are unknown. We aimed to determine the effects of repetitive facilitative exercise on spasticity using the Modified Ashworth Scale (MAS) and the F-wave, and to determine the relationship between the changes in spasticity and functional recovery of the hemiplegic upper limb. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 30, 2018 Category: Neurology Authors: Seiji Etoh, Tomokazu Noma, Ryuji Miyata, Megumi Shimodozono Source Type: research

Differences in Fracture Incidence According to Caregiver Type in Stroke Survivors
To assess whether the type of primary caregiver is a risk factor of the incidence of fracture among older adults who have survived a stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 30, 2018 Category: Neurology Authors: Juyeong Kim, Kyoung Hee Cho, Sang Gyu Lee, Ye Seol Lee, Sung-In Jang, Eun-Cheol Park Source Type: research

Early Diffusion-Weighted Imaging Brain Stem Score for Acute Basilar Artery Occlusion Treated with Mechanical Thrombectomy
The diffusion-weighted imaging (DWI) brain stem score (BSS) is an easy to use and can predict the clinical outcome of acute basilar artery occlusion (BAO) who underwent endovascular thrombectomy. The purpose of the current study was to validate its performance in Chinese acute BAO patients treated with mechanical thrombectomy. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 30, 2018 Category: Neurology Authors: Haihua Yang, Ning Ma, Lian Liu, Feng Gao, Dapeng Mo, Xuan Sun, Zhongrong Miao Source Type: research

Coagulation Profile after Spontaneous Intracerebral Hemorrhage: A Cohort Study
Intracerebral hemorrhage (ICH) causes death or disability and the incidence increases with age. Knowledge of acute hemostatic function in patients with ICH without anticoagulant and antiplatelet therapy is sparse. Increased knowledge of the coagulation profile in the acute phase of ICH could improve acute treatment and recovery. We investigated coagulation at admission and changes in coagulation during the first 24 hours after symptom onset. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 30, 2018 Category: Neurology Authors: Signe Voigt Lauridsen, Anne-Mette Hvas, Emilie Sandgaard, Tua Gyldenholm, Christian Rahbek, Niels Hjort, Else Kirstine T ønnesen, Christine Lodberg Hvas Source Type: research

Association of Transthoracic Echocardiography Findings and Long-Term Outcomes in Patients Undergoing Workup of Stroke
Transthoracic echocardiography (TTE) has become routine as part of initial stroke workup to assess for sources of emboli. Few studies have looked at other TTE findings such as ejection fraction, wall motion abnormalities, valve disease, pulmonary hypertension and left ventricular hypertrophy and their association with various subtypes of stroke, long-term outcomes of recurrent stroke, and all-cause mortality. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 30, 2018 Category: Neurology Authors: Jeremy A. Miles, Leonid Garber, Subha Ghosh, Daniel M. Spevack Source Type: research

The Value of Exercise Rehabilitation Program Accompanied by Experiential Music for Recovery of Cognitive and Motor Skills in Stroke Patients
The aim of this study was to systematically assess the effects of exercise rehabilitation program accompanied by experiential music for clinical recovery. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 30, 2018 Category: Neurology Authors: George Fotakopoulos, Polikceni Kotlia Source Type: research

The HOPES Registry – Houston Methodist Hospital Outcomes-based Prospective Endpoints in Stroke
We present a single institution registry with the novel feature of 90-day outcome assessments on all hospitalized acute stroke patients, inclusive of every patient with a primary discharge diagnosis of transient ischemic attack (TIA), acute ischemic stroke (AIS), nontraumatic subarachnoid hemorrhage (SAH), and intracerebral hemorrhage (ICH). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 30, 2018 Category: Neurology Authors: Rajan Gadhia, David McCane, Jason Lee, Ken Chyuan Ling, Kevin Jiang, David Chiu Source Type: research

A Meta-Analysis of the Association between Microrna-196A2 and Risk of Ischemic Stroke and Coronary Artery Disease in Asian Population
Single nucleotide polymorphisms (SNPs) of small non-coding RNAs (sncRNAs) that affect the sncRNA function and target gene expression to mediate the risk of certain diseases. The association between the miR-196a2 rs11614913 and ischemic stroke (IS) and coronary artery disease (CAD) is still conflicting and inconclusive. This meta-analysis aimed at analysing studies which have been done so far to get a more precise assessment of the association between the mutation and these two diseases. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 30, 2018 Category: Neurology Authors: Yue Wang, Qian Li, Michael Mambiya, Kaili Zhang, Luping Yang, Qian Zhang, Shan Liu, Mengwei Liu, Jiali Yin, Wanyang Liu Source Type: research

Role of Steroid Therapy after Ischemic Stroke by n-Methyl-d-Aspartate Receptor Gene Regulation
This study aimed to investigate progesterone impact on the expression of NMDA receptor subunits NR1, NR2 (A and B), NR3 (A and B) after an experimental model of ischemic stroke which is followed by an in silico analysis. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 30, 2018 Category: Neurology Authors: Abolfazl Azami Tameh, Mohammad Karimian, Zahra Zare-Dehghanani, Younes Aftabi, Cordian Beyer Source Type: research

Translational Evaluation of Acid/Base and Electrolyte Alterations in Rodent Model of Focal Ischemia
Acid/base and electrolytes could provide clinically valuable information about cerebral infarct core and penumbra. We evaluated associations between acid/base and electrolyte changes and outcomes in 2 rat models of stroke, permanent, and transient middle cerebral artery occlusion. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 29, 2018 Category: Neurology Authors: Sarah R. Martha, Lisa A. Collier, Stephanie M. Davis, Hilary A. Seifert, Christopher C. Leonardo, Craig T. Ajmo, Elspeth A. Foran, Justin F. Fraser, Keith R. Pennypacker Source Type: research

Paroxysmal Sympathetic Hyperactivity after Surgery for Cerebral Hemorrhagic Arteriovenous Malformation: A Case Report
Paroxysmal sympathetic hyperactivity is a condition involving a sudden increase in body temperature, heart rate, blood pressure, respiratory rate, sweating, and posturing followed by severe brain injury. Most of the reported preceding disorders involve head trauma, followed by anoxic brain injury, and stroke. Here, we report an extremely rare case of 17-year-old man diagnosed with hemorrhagic arteriovenous malformation, underwent emergent surgery, was on prolonged sedation due to postoperative complications, and subsequently developed paroxysmal sympathetic hyperactivity. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 29, 2018 Category: Neurology Authors: Hiroki Yamada, Ryogo Kikuchi, Jumpei Katayama, Akiyoshi Nakamura, Hiromichi Miyazaki Source Type: research

Correlation of Changes in Leukocytes Levels 24 Hours after Intravenous Thrombolysis With Prognosis in Patients With Acute Ischemic Stroke
This study aims to demonstrate the value of changes in leukocytes levels 24 hours after intravenous thrombolysis to predict prognosis in acute ischemic stroke (AIS). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 29, 2018 Category: Neurology Authors: Jie Chen, Zengrui Zhang, Luyun Chen, Xiaowen Feng, Wangwang Hu, Wanqian Ge, Xianmei Li, Pingping Jin, Bei Shao Source Type: research

A Chinese CARASIL Patient Caused by Novel Compound Heterozygous Mutations in HTRA1
Our objective is to reported a Chinese CARASIL patient caused by novel compound heterozygous mutations in HTRA1. Detailed clinical and neuroimaging examination were conducted in proband and her available family members. Sanger sequencing of NOTCH3 and HTRA1 was used to investigate causative mutations. The patient was born in an outbred family. She experienced recurrent transient ischemic attacks, hair loss, and low back pain. Brain magnetic resonance imaging showed multiple lacunar infarctions, diffuse leukoencephalopathy, and multiple microbleeds of white matter. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 29, 2018 Category: Neurology Authors: Fei Xie, Li-san Zhang Tags: Case Study Source Type: research

Spontaneous Spinal Subarachnoid Hemorrhage: Presentation and Outcome
Spontaneous spinal subarachnoid hemorrhage (SSAH) is a rare but serious condition that can lead to a variety of medical complications. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 28, 2018 Category: Neurology Authors: Micah D. Yost, Alejandro A. Rabinstein Source Type: research

The Prognostic Value of CT-Angiographic Parameters After Reperfusion Therapy in Acute Ischemic Stroke Patients With Internal Carotid Artery Terminus Occlusion: Leptomeningeal Collateral Status and Clot Burden Score
The objective of this study was to investigate the prognostic value of computed tomographic angiography (CTA) based on leptomeningeal collateral (LMC) status and other parameters in acute ischemic stroke (AIS) patients with internal carotid artery (ICA) terminus occlusion treated with endovascular treatment (EVT). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 28, 2018 Category: Neurology Authors: Jung-Soo Park, Hyo-Sung Kwak, Gyung Ho Chung, Seungbae Hwang Source Type: research

Is Management of Central Retinal Artery Occlusion the Next Frontier in Cerebrovascular Diseases?
Central retinal artery occlusion (CRAO) is a medical emergency that, if not treated, may result in irreversible loss of vision. It continues to be an important cause for acute painless loss of vision. Amaurosis fugax or “transient CRAO” has long been considered an equivalent of transient cerebral ischemic event. Animal models, in addition to data from retrospective and randomized clinical studies, provide valuable insights into the time interval for irreversible retinal ischemia. Subset analyses from 2 large st udies of patients with CRAO show benefit from treatment with thrombolysis within 6 hours from symptom...
Source: Journal of Stroke and Cerebrovascular Diseases - July 27, 2018 Category: Neurology Authors: Kaustubh Limaye, Michael Wall, Sami Uwaydat, Sheharayar Ali, Amir Shaban, Sami Al Kasab, Harold Adams Source Type: research

Stroke Mimics Transported by Emergency Medical Services to a Comprehensive Stroke Center: The Magnitude of the Problem
Despite the use of validated prehospital stroke scales, stroke mimics are frequent among patients transported by Emergency Medical Services to the Emergency Department. We aimed to describe the frequency and characteristics of neurological and non-neurological mimics transported to a comprehensive stroke center for acute stroke evaluation. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 26, 2018 Category: Neurology Authors: Joel Neves Briard, Rahel T. Zewude, Mahesh P. Kate, Brian H. Rowe, Brian Buck, Ken Butcher, Laura C. Gioia Source Type: research

C-Reactive Protein and T3: New Prognostic Factors in Acute Ischemic Stroke
Several studies have shown that high level of plasma C-reactive protein (CRP) is associated with stroke outcomes and future vascular events, and a decrease in serum triiodothyronine (T3) was reported to be associated with stroke severity and poor prognosis. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 26, 2018 Category: Neurology Authors: Claudia-Alexandrina Irimie, Mihai V ârciu, Marius Irimie, Petru-Iulian Ifteni, Dan-Ioan Minea Source Type: research

Implications of Janus Kinase 2 Mutation in Embolic Stroke of Unknown Source
The role of genetic mutations in cerebral ischemia is not completely understood. Among these genetic variations, Philadelphia-negative gain-of-function mutation in the janus kinase 2 (JAK2) protein leads to overexpression of the genes involved in cell growth and proliferation, and has been linked to development of hematological malignancies, specifically, myeloproliferative neoplasms (MPNs; essential thrombocythemia [ET], polycythemia vera [PV], and primary myelofibrosis). Overt ET and PV are known to induce a prothrombotic state that leads to development of vascular complications, including cerebral arterial or venous thr...
Source: Journal of Stroke and Cerebrovascular Diseases - July 26, 2018 Category: Neurology Authors: Gabriela Trifan, Neelofer Shafi, Fernando D. Testai Source Type: research

The Association Between ACE2 Gene Polymorphism and the Stroke Recurrence in Chinese Population
The angiotensin-converting enzyme 2 (ACE2) is closely associated with cardiovascular disease and cerebrovascular disease. Most studies on ACE2 gene polymorphism focused on its relations with cardiovascular disease, but there was a lack of research on its relations with stroke. Our study aimed to explore the association between 4 single-nucleotidepolymorphisms (SNPs) of ACE2 gene polymorphism and stroke recurrence. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 26, 2018 Category: Neurology Authors: Xiaomei Wu, Bo Zhu, Safeng Zou, Jingpu Shi Source Type: research

Low Free Triiodothyronine Predicts 3-Month Poor Outcome After Acute Stroke
The association between thyroid hormone levels and long-term clinical outcome in patients with acute stroke has not yet been thoroughly studied. The purpose of the present study was to test the hypothesis that thyroid hormone levels are associated with 3-month functional outcome and mortality after acute stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 26, 2018 Category: Neurology Authors: Satoshi Suda, Takashi Shimoyama, Koichiro Nagai, Masafumi Arakawa, Junya Aoki, Takuya Kanamaru, Kentaro Suzuki, Yuki Sakamoto, Yuho Takeshi, Noriko Matsumoto, Yasuhiro Nishiyama, Chikako Nito, Masahiro Mishina, Kazumi Kimura Source Type: research

Neurosarcoidosis Flare with Multifocal Restricted Diffusion: Stroke, Inflammation, or Both?
We present a case of a patient with both leptomeningeal enhancement and multifocal restricted diffusion in a patient with sarcoidosis. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 25, 2018 Category: Neurology Authors: Elizabeth Spurgeon, Justin Abbatemarco, Richard Prayson, Mary Willis Tags: Case Report Source Type: research

Thrombolysis with rt-PA under Rivaroxaban Anticoagulation in a Hypertensive Rat Model of Intraluminal Middle Cerebral Artery Occlusion
The aim of this study was to assess the risk and the threshold of hemorrhagic transformation (HT) after treatment with recombinant tissue plasminogen activator (rtPA) under the novel oral anticoagulant, rivaroxaban. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 25, 2018 Category: Neurology Authors: Hiroshi Izuma, Fumiaki Oka, Hideyuki Ishihara, Takao Inoue, Eiichi Suehiro, Sadahiro Nomura, Michiyasu Suzuki Source Type: research

Cerebral Vasoreactivity in Children with Sickle Cell Disease: A Transcranial Doppler Study
We examined the hypothesis that children with SCD would also have a higher frequency of impaired cerebral vasoreactivity when compared with healthy age- and gender-matched controls. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 24, 2018 Category: Neurology Authors: Rejane de Souza Macedo-Campos, Samuel Ademola Adegoke, Maria Stella Figueiredo, Josefina Aparecida Pellegrini Braga, Gisele Sampaio Silva Source Type: research

Subacute Methotrexate Encephalopathy Mimicking Ischemic Stroke With Dynamic Changes on Magnetic Resonance Imaging
We report a 35-year-old woman who suddenly developed left hemiparesis and dysarthria at 13 days after treatment with intrathecal and intravenous methotrexate for intravascular large B cell lymphoma with possible central nervous system infiltration. Seven hours after onset, she developed further right hemiparesis and aphasia. However, the majority of neurologic symptoms disappeared spontaneously and completely by 34 hours. We also recorded the dynamic progression and regression of abnormal signals in the bilateral corona radiata on diffusion-weighted imaging, in parallel with neurologic symptoms. (Source: Journal of Stroke ...
Source: Journal of Stroke and Cerebrovascular Diseases - July 23, 2018 Category: Neurology Authors: Kei Yamanaka, Takuya Okata, Yoshiki Sambongi, Ikumi Yamanaka, Kazuki Tanimoto, Tetsuro Ago, Takanari Kitazono, Jiro Kitayama Tags: Case Report Source Type: research

Highest In-Hospital Glucose Measurements are Associated With Neurological Outcomes After Intracerebral Hemorrhage
The relationship between in-hospital hyperglycemia and neurological outcome after intracerebral hemorrhage (ICH) is not well studied. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 22, 2018 Category: Neurology Authors: Jonathan Rosenthal, Aaron Lord, Koto Ishida, Jose Torres, Barry M. Czeisler, Ariane Lewis Source Type: research

The Association Between Atrial Fibrillation and Poststroke Seizures is Influenced by Ethnicity and Environmental Factors
This study assessed whether ethnicity affects the association between AF and poststroke seizure (PSS) development. We hypothesized that Royal Melbourne Hospital ([RMH] Melbourne) patients will have significantly higher incidence of AF-related PSS than in the Jinling Hospital (Nanjing) population. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 21, 2018 Category: Neurology Authors: Jillian Naylor, Leonid Churilov, Benjamin Johnstone, Ruibing Guo, Yunyun Xiong, Miriam Koome, Ziyi Chen, Arthur Thevathasan, Ziyuan Chen, Xinfeng Liu, Patrick Kwan, Bruce C.V. Campbell Source Type: research

Therapeutically Targeting Platelet-Derived Growth Factor-Mediated Signaling Underlying the Pathogenesis of Subarachnoid Hemorrhage-Related Vasospasm
Vasospasm accounts for a large fraction of the morbidity and mortality burden in patients sustaining subarachnoid hemorrhage (SAH). Platelet-derived growth factor (PDGF)- β levels rise following SAH and correlate with incidence and severity of vasospasm. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 20, 2018 Category: Neurology Authors: Michael George Zaki Ghali, Visish M. Srinivasan, Jeremiah Johnson, Peter Kan, Gavin Britz Tags: Review Article Source Type: research

Helicopter “Drip and Ship” Flights Do Not Alter the Pharmacological Integrity of rtPA
Rural and critical access hospitals rely on the “drip and ship” practice using helicopter emergency medical services (HEMS). But those helicopter flights are an unusual environment with physical factors such as vibration and accelerations that could potentially affect the stability, and pharmacological properties of IV rtPA, an issue that has not been previously addressed. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 20, 2018 Category: Neurology Authors: Brett A. Faine, Sanjana Dayal, Rahul Kumar, Steven R. Lentz, Enrique C. Leira Source Type: research

Acute Stroke Patients With Mild-to-Moderate Pre-existing Disability Should Be Considered for Thrombolysis Treatment
Thrombolytic therapy in patients with pre-existing disability presenting with acute ischemic stroke (AIS) is controversial because of concerns regarding poor outcomes and futility of treatment. We hypothesized that a similar proportion of patients with and without pre-existing disability would return to their premorbid functional status following thrombolysis. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 20, 2018 Category: Neurology Authors: Wenwen Zhang, Skye Coote, Tanya Frost, Helen M. Dewey, Philip M.C. Choi Source Type: research

Impaired Brachial Flow-Mediated Dilatation May Predict Symptomatic Intracranial Arterial Dissections
Spontaneous intracranial arterial dissections are characterized by the sudden disruption of the internal elastic lamina in the intracranial arteries. The purpose of our retrospective study was to investigate whether patients with nontraumatic intracranial arterial dissections had normal endothelial function. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 19, 2018 Category: Neurology Authors: Tomonori Iwata, Takahisa Mori, Yuhei Tanno, Shigen Kasakura, Kazuhiro Yoshioka Source Type: research

Isolated Upper Limb Weakness From Ischemic Stroke: Mechanisms and Outcome
To characterize isolated upper extremity (UE) weakness from stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 19, 2018 Category: Neurology Authors: Mehmet Akif Topcuoglu, Eva A. Rocha, Ahmer Khawdja Siddiqui, Brittany B. Mills, Gisele S. Silva, Lee H. Schwamm, Glenn M. Lamuraglia, Aneesh B. Singhal Source Type: research

Evaluation of the Safety and Efficacy of the Therapeutic Potential of Adipose-Derived Stem Cells Injected in the Cerebral Ischemic Penumbra
Stroke represents an attractive target for cell therapy. Although different types of cells have been employed in animal models with variable results, the human adipose-derived stem cells (hASCs) have demonstrated favorable characteristics in the treatment of diseases with inflammatory substrate, but experience in their intracerebral administration is lacking. The purpose of this study is to evaluate the effect and safety of the intracerebral application of hASCs in a stroke model. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 18, 2018 Category: Neurology Authors: Ulises G ómez-Pinedo, Leyre Sanchez-Rojas, María Soledad Benito-Martin, Cristina Lendinez, Gonzalo León-Espinosa, Fernando Rascón, Jone Herrero, Begoña Castro, Lidia Moreno-Jiménez, Maite del Olmo, Jordi A. Matias-Guiu, Jorge Matias-Guiu, Juan A. Ba Source Type: research

Cerebral Paragonimiasis With Hemorrhagic Stroke in a Developed Country
Paragonimiasis is a food-borne parasitic disease caused by Paragonimus lung flukes, which are epidemic in Asia. Cerebral paragonimiasis accounts for (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 18, 2018 Category: Neurology Authors: Yumi Kashida, Masaki Niiro, Haruhiko Maruyama, Ryosuke Hanaya Source Type: research

Limb Shaking Transient Ischemic Attacks with Normal Neurovascular Ultrasound may Herald Cardioembolic Stroke: ACase Report
We describe a 74 year-old woman with abrupt left arm jerking and normal urgent computed tomography scan, electroencephalography (EEG) as well as carotid and transcranial ultrasound. Two days later she developed an overt ischemic stroke, with left mesencephalon and left cerebellar hemisphere lesions at brain magnetic resonance imaging and paroxysmal atrial fibrillation at Holter-EKG. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 17, 2018 Category: Neurology Authors: Emanuele Bartolini, Alessandro Napolitano, Monica Mazzoni Tags: Case Report Source Type: research

Safety of Recanalization Therapy in Patients with Acute Ischemic Stroke Under Anticoagulation: A Systematic Review and Meta-Analysis
Intravenous thrombolysis treatment (IVT) and endovascular therapy (EVT) have been proved as fist-line beneficial option for eligible patients who have acute ischemic stroke (AIS) with major safety concern of symptomatic intracranial hemorrhage (sICH). Unfortunately, the emergency management of patients with AIS taking vitamin K antagonists and with international normalized ratio  higher than 1.7 or taking new oral anticoagulants (NOACs) represents a great challenge. We aim to comprehensively determine the safety of EVT in patients under prior-stroke anticoagulants and IVT in patients under NOAC use. (Source: ...
Source: Journal of Stroke and Cerebrovascular Diseases - July 15, 2018 Category: Neurology Authors: Mingsu Liu, Yang Zheng, Guangqin Li Tags: Review Article Source Type: research

Masthead
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 5, 2018 Category: Neurology Source Type: research

Editorial Board
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 5, 2018 Category: Neurology Source Type: research

Table of Contents
(Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 5, 2018 Category: Neurology Source Type: research

The Importance of the Full Blood Count in Cerebral Ischemia: A Review of 609 Consecutive Young Patients with Stroke and Transient Ischemic Attacks
Almost half of ischemic strokes in young individuals are cryptogenic. Thrombophilia testing is routinely sent despite limited evidence linking to arterial cerebrovascular events. A full blood count may identify underlying hematological disorder. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 5, 2018 Category: Neurology Authors: Alice Taylor, Vafa Alakbarzade, Arvind Chandratheva, Robert Simister, Marie Scully Source Type: research

Readmissions After Mechanical Thrombectomy for Acute Ischemic Stroke in the United States: A Nationwide Analysis
Mechanical thrombectomy after acute ischemic stroke has been shown to improve clinical outcomes. Data on short-term hospitalization outcomes after thrombectomy are needed. Our objective was to quantify 30- and 90-day readmissions after thrombectomy and identify factors associated with readmissions. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 3, 2018 Category: Neurology Authors: Preethi Ramchand, Dylan P. Thibault, James A. Crispo, Joshua Levine, Robert Hurst, Michael T. Mullen, Scott Kasner, Allison W. Willis Source Type: research

Liraglutide Protects Neurite Outgrowth of Cortical Neurons Under Oxidative Stress though Activating the Wnt Pathway
Neurogenesis including neurite outgrowth is important for brain plasticity under physiological conditions and in brain repair after injury. Liraglutide has been found to have neuroprotective action in the risk of central nervous system disease. However, the effect and the potential mechanism of liraglutide-induced neurite outgrowth in primary cortical neurons under oxidative stress remain poorly documented. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 3, 2018 Category: Neurology Authors: Weiliang He, Xiaochao Tian, Mimi Lv, Hebo Wang Source Type: research

Modern Interdisciplinary and Interhospital Acute Stroke Therapy —What Patients Think About It and What They Really Understand
Access to reperfusion therapies in patients with large vessel occluding acute ischemic stroke demands process reorganization and optimization. Neurovascular networks are being built up to provide 24/7 endovascular stroke therapy service. In times of an increasingly complex stroke rescue chain little is known about patients ’ and their relatives’ treatment awareness. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 2, 2018 Category: Neurology Authors: Hannah Pressler, Arno Reich, J örg Bernhard Schulz, Omid Nikoubashman, Klaus Willmes, Pardes Habib, Jan-Philipp Bach Source Type: research

Selection of Oral Anticoagulants in Ischemic Stroke Patients with Nonvalvular Atrial Fibrillation
Anticoagulant therapy is indicated for management of ischemic stroke patients with nonvalvular atrial fibrillation. We retrospectively investigated how oral anticoagulants were selected for ischemic stroke patients with nonvalvular atrial fibrillation. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 2, 2018 Category: Neurology Authors: Ichiro Deguchi, Norio Tanahashi, Masaki Takao Source Type: research

Comparison of Premortem Magnetic Resonance Imaging and Postmortem Autopsy Findings of a Cortical Microinfarct
An 85-year-old woman diagnosed with amyotrophic lateral sclerosis died of pneumonia and was autopsied. Magnetic resonance imaging (MRI) performed 16days before death revealed an intracortical high-intensity lesion in her right temporal cortex on three-dimensional (3D)-double inversion recovery (DIR) and 3D-fluid-attenuated inversion recovery (FLAIR) images. Histopathological examination indicated a cortical microinfarct (CMI) juxtaposed to cerebral amyloid angiopathy. Recently, in vivo detection of CMIs using 3D-DIR and 3D-FLAIR on 3-tesla MRI has been reported, and postmortem MRI study confirmed the presence of CMIs. (Sou...
Source: Journal of Stroke and Cerebrovascular Diseases - July 2, 2018 Category: Neurology Authors: Hidehiro Ishikawa, Yuichiro Ii, Atsushi Niwa, Akihiro Shindo, Ai Ito, Keita Matsuura, Ryogen Sasaki, Kenichiro Uno, Masayuki Maeda, Hidekazu Tomimoto Source Type: research