Cholesterol Crystal in Thrombus Removed by Mechanical Thrombectomy Should be a Strong Marker for Aortogenic Embolic Stroke
Aortogenic embolic stroke (AES) is an important stroke mechanism. However, as many stroke patients have aortic atheromatous lesions, it is unclear whether these lesions are the cause of these strokes. Cholesterol crystals are the solid, crystalline form of cholesterol that is found in atherosclerosis, but not in cardiac diseases such as atrial fibrillation, valvular diseases, and cardiomyopathy. Therefore, if a cholesterol crystal is found in a thrombus removed by mechanical thrombectomy (MT), this makes it possible to diagnose a patient as having an atheromatous lesion. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 11, 2020 Category: Neurology Authors: Noriko Matsumoto, Mizuho Takahashi, Takehiro Katano, Akihito Kutsuna, Takuya Kanamaru, Yuki Sakamoto, Kentaro Suzuki, Junya Aoki, Yasuhiro Nishiyama, Shinobu Kunugi, Akira Shimizu, Kazumi Kimura Tags: Case Report Source Type: research

Clinical Characteristics and Clinical Course of Body Lateropulsion in 47 Patients with Brainstem Infarctions
In patients with lower lateral medullary infarction (LMI) located under the vestibular nucleus, proprioceptive impairment due to dorsal spinocerebellar tract (DSCT) is considered a pathological condition for body lateropulsion. In patients with brainstem infarction located at or above the level of the vestibular nucleus, other pathways, such as the crossed vestibulothalamic tract (CVTT), are considered responsible. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 11, 2020 Category: Neurology Authors: Tameto Naoi, Mitsuya Morita, Koki Kosami, Takafumi Mashiko, Tomoaki Kameda, Shunich Okada, Yuka Hayashi, Tadataka Kawakami, Ryota Tanaka, Shigeru Fujimoto Source Type: research

Otogenic Lateral Sinovenous Thrombosis in Children: A Case Series from a Single Centre and Narrative Review
We aimed to describe otogenic lateral sinovenous thrombosis (OLST), a rare, potentially life-threatening complication of otomastoiditis. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 11, 2020 Category: Neurology Authors: Sandra Trapani, Micol Stivala, Donatella Lasagni, Anna Rosati, Giuseppe Indolfi Source Type: research

Effect of Care Capacity on Stroke Patients ’ Recovery in Activities of Daily Living: A Multi-Hospital Study
This study aimed to investigate whether care capacity for patients following stroke contributes to improved activities of daily living (ADL) at discharge from hospital based on the degree of stroke severity. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 11, 2020 Category: Neurology Authors: Motoya Sugiyama, Katsunori Kondo, Seungwon Jeong, Nariaki Shiraishi, Daisuke Matsumoto, Takahiro Hayashi, Hirotaka Tanaka Source Type: research

COVID-19 and Stroke: Incidence and Etiological Description in a High-Volume Center
An increased rate of thrombotic events has been associated to Coronavirus Disease 19 (COVID-19) with a variable rate of acute stroke. Our aim is to uncover the rate of acute stroke in COVID-19 patients and identify those cases in which a possible causative relationship could exist. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 5, 2020 Category: Neurology Authors: Manuel Requena, Marta Oliv é-Gadea, Marian Muchada, Álvaro García-Tornel, Matías Deck, Jesús Juega, Sandra Boned, Noelia Rodríguez-Villatoro, Carlos Piñana, Jorge Pagola, David Rodríguez-Luna, David Hernández, Marta Rubiera, Alejandro Tomasello, Source Type: research

COVID-19 and Stroke: incidence and etiological description in a high-volume center.
An increased rate of thrombotic events has been associated to Coronavirus Disease 19 (COVID-19) with a variable rate of acute stroke. Our aim is to uncover the rate of acute stroke in COVID-19 patients and identify those cases in which a possible causative relationship could exist. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 4, 2020 Category: Neurology Authors: Manuel Requena, Marta Oliv é, Marian Muchada, Álvaro García-Tornel, Matías Deck, Jesús Juega, Sandra Boned, Noelia Rodríguez-Villatoro, Carlos Piñana, Jorge Pagola, David Rodríguez-Luna, David Hernández, Marta Rubiera, Alejandro Tomasello, Carlos Source Type: research

Malignant Cerebral Ischemia in A COVID-19 Infected Patient: Case Review and Histopathological Findings
Severe acute respiratory syndrome coronavirus (SARS-CoV-2) is responsible for an unprecedented worldwide pandemic that has severely impacted the United States. As the pandemic continues, a growing body of evidence suggests that infected patients may develop significant coagulopathy with resultant thromboembolic complications including deep vein thrombosis, pulmonary embolism, myocardial infarction, and ischemic stroke. However, this data is limited and comes from recent small case series and observational studies on stroke types, mechanisms, and outcomes. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 4, 2020 Category: Neurology Authors: Smit D. Patel, Ryan Kollar, Patrick Troy, Xianyuan Song, Mohammad Khaled, Augusto Parra, Mubashir Pervez Source Type: research

Environmental factors and hyperacute stroke care activity during the COVID-19 pandemic: An interrupted time-series analysis.
Concerns have arisen regarding patient access and delivery of acute stroke care during the COVID-19 pandemic. We investigated key population level events on activity of the three hyperacute stroke units (HASUs) within Greater Manchester and East Cheshire (GM& EC), whilst adjusting for environmental factors. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 3, 2020 Category: Neurology Authors: Matthew Gittins, Christopher Ashton, Neil Holden, Stephen Cross, Srinath Meadipudi, Khalil Kawafi, Ilse Burger, Sarah Rickard, Andy Vail, Jane Molloy, Craig J. Smith Source Type: research

Anticoagulant approach in COVID-19 patients with cerebral venous thrombosis
We appreciate Klein et al. [1] for reporting the case of cerebral venous thrombosis accompanied by hemorrhagic infarct in a young patient with novel coronavirus disease 2019 (COVID-19). The reporting of such a case would raise the awareness of the possibility of the occurrence of cerebral venous thrombosis in the course of COVID-19, especially among the young adults present with COVID-19 and neurological symptoms. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 2, 2020 Category: Neurology Authors: Chia Siang Kow, Abdullah Faiz Zaihan, Syed Shahzad Hasan Source Type: research

Early speech-language rehabilitation for stroke patients during the Covid-19 outbreak
This article emphasizes the importance of maintaining a high standard quality of care for patients with acute stroke even if usual practices will have to be modified. Authors include rehabilitation as an integral part of stroke recovery. We strongly support this position: in this letter we would like to share our experience of delivering. speech-language rehabilitation for stroke inpatients during the Covid-19 outbreak. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 30, 2020 Category: Neurology Authors: Patrizia Mammi, Chiara Bidini, Elena Ablondi, Maria Rosaria David, Rodolfo Brianti Source Type: research

Author's response to Letter to the Editor: Anticoagulant approach in COVID-19 patients with cerebral venous thrombosis.
We thank the Journal and the authors for the opportunity to further elaborate on the issue of anticoagulation choice raised in Siang et al's letter to the editor1. We appreciate Siang et al. raising this topic as it acutely impacts management of care and is becoming increasingly relevant as the number of reported thrombotic events associated with SARS-CoV-2 continues to rise. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 30, 2020 Category: Neurology Authors: David E. Klein, Richard Libman, Claudia Kirsch, Rohan Arora Source Type: research

Letter to the Editor regarding “Cardiac-Neurovascular Adverse Effects Responsible to Contrast Transcranial Doppler: A case report”
We read with interest a case report by Mo et al. A 44 years-old woman experienced a hemodynamic abnormality due to massive air embolism from a large right-to-left shunt associated with ventricular septal defect (VSD). After saline-bubble contrast injection, the curtain pattern of air embolisms for over 100 seconds in the middle cerebral artery was detected by the transcranial Doppler (TCD).1 (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 29, 2020 Category: Neurology Authors: Sombat Muengtaweepongsa, Sirinat Puengcharoen Tags: Letter to the Editor Source Type: research

Posterior Reversible Encephalopathy Syndrome in Patients with Coronavirus Disease 2019: Two Cases and a Review of the Literature
Central nervous system (CNS) manifestations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection include encephalopathy, encephalitis, meningitis, acute disseminated encephalomyelitis, and stroke [1], both as a result of direct viral invasion of the central nervous system [2 –5] and as a consequence of critical illness and systemic infection [6]. Coronavirus disease 2019 (COVID-19) may also cause significant changes in endothelial morphology, including disruption of intercellular junctions, cell swelling, and a loss of contact with the basal membrane [7]. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 29, 2020 Category: Neurology Authors: Pria Anand, K. H.Vincent Lau, David Y Chung, Deepti Virmani, Anna M. Cervantes-Arslanian, Asim Mian, Courtney E. Takahashi Source Type: research

Roadmap for Resuming Elective Neuroendovascular Procedures Following the First COVID-19 Surge
The COVID-19 pandemic led to prioritizing high-acuity care of COVID-19 patients, while deferring non-emergent neurointerventional procedures worldwide in order to both limit contagion and add capacity for the anticipated COVID-19 surge. More specifically, health care resources, health care workers, and personal protective equipment (PPE) were all reorganized to ensure availability for the anticipated care of COVID-19 patients. As we emerge from the peak of the COVID-19 pandemic's initial surge, we prepare for re-entry of elective neurointerventional procedures to optimize the care of patients and mitigate infectious risk, ...
Source: Journal of Stroke and Cerebrovascular Diseases - July 26, 2020 Category: Neurology Authors: Mohamad Abdalkader, Anvitha Sathya, Adel M. Malek, Johanna T. Fifi, Alexander M. Norbash, Ajay K. Wakhloo, Thanh N. Nguyen Source Type: research

Intravenous tPA for Acute Ischemic Stroke in Patients with COVID-19
We present a multicenter case series from 9 centers in the United States of patients with acute neurological deficits consistent with AIS and COVID-19 who were treated with IV tPA.Results: We identified 13 patients (mean age 62 ( ±9.8) years, 9 (69.2%) male). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 26, 2020 Category: Neurology Authors: Thiago Carneiro, Jonathan Dashkoff, Lester Y. Leung, Christa O'Hana S. Nobleza, Erika Marulanda-Londono, Mausaminben Hathidara, Sebastian Koch, Nicole Sur, Alexandra Boske, Barbara Voetsch, Hassan Aboul Nour, Daniel J Miller, Ali Daneshmand, Julie Shulman Source Type: research

Clinician's Perception of Practice Changes for Stroke During the COVID-19 Pandemic
In this study, we investigated the changes in practices and policies related to stroke care through an online survey. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 21, 2020 Category: Neurology Authors: Hera A. Kamdar, Blake Senay, Shraddha Mainali, Vivien Lee, Deepak Kumar Gulati, Diana Greene-Chandos, Archana Hinduja, Tamara Strohm Source Type: research

Current Recommendations for the Management of Stroke Patients in the Middle East in the Era of COVID-19 Pandemic; Statement from the MENA SINO
COVID-19 pandemic has led to a change in the way we manage acute medical illnesses. This pandemic had a negative impact on stroke care worldwide. The World Stroke Organization (WSO) has raised concerns due to the lack of available care and compromised acute stroke services globally. The numbers of thrombolysis and thrombectomy therapies are declining. As well as, the rates and door-to treatment times for thrombolysis and thrombectomy therapies are increasing. The stroke units are being reallocated to serve COVID-19 patients, and stroke teams are being redeployed to COVID-19 centers. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 21, 2020 Category: Neurology Authors: Amal Al Hashmi, Atilla Ozcan Ozdemir, Ashfaq Shuaib, Hosam AlJehani, Ossama Mansour, Adel Alhazzani, Farid Aladhem, Mehdi Farhoudi, Seby John, Maher Saqqur Source Type: research

Care for Patients with Stroke During the COVID-19 Pandemic: Physical Therapy and Rehabilitation Suggestions for Preventing Secondary Stroke
Infection with the novel severe acute respiratory syndrome coronavirus 2 causes the development of the novel 2019 coronavirus disease (COVID-19) and associated clinical symptoms, which typically presents as an upper respiratory syndrome such as pneumonia. Growing evidence indicates an increased prevalence of neurological involvement (e.g., in the form of stroke) during virus infection. COVID-19 has been suggested to be more than a lung infection because it affects the vasculature of the lungs and other organs and increases the risk of thrombosis. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 21, 2020 Category: Neurology Authors: Chien-Chih Wang, Jian-Kang Chao, Mong-Lien Wang, Yi-Ping Yang, Chien-Shiu Chien, Wei-Yi Lai, Yi-Chiang Yang, Yu-Hui Chang, Chen-Liang Chou, Chung-Lan Kao Source Type: research

Impact of the coronavirus disease pandemic on the number of strokes and mechanical thrombectomies: A systematic review and meta-analysis
This systematic review and meta-analysis aimed to evaluate the impact of the coronavirus disease (COVID-19) pandemic on stroke care, including the number of stroke alerts/codes, number of reperfusions, and number of thrombectomies during the pandemic compared to those during the pre-pandemic period. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 21, 2020 Category: Neurology Authors: Julius July, Raymond Pranata Source Type: research

Code Stroke patient referral by Emergency Medical Services during the public COVID-19 pandemic lockdown
During the coronavirus disease 2019 (COVID-19) pandemic the use of health care systems changed suddenly. Hospitals were overwhelmed as a result of the staggering COVID-19 patient numbers1 and/or modified their daily routine due to prophylactic allocation of resources.2 Public lockdowns with strict containment recommendations for the community have been announced around the world.3 Emergency Medical Services (EMS) and dispatch centers were confronted with increasing numbers of patients/calls and reorganization of the dispatch system including Code Stroke patient referral. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 20, 2020 Category: Neurology Authors: Benno Ikenberg, Bernhard Hemmer, Michael Dommasch, Karl-Georg Kanz, Silke Wunderlich, Benjamin Knier Source Type: research

Acute Stroke as the Presenting Symptom of SARS-CoV-2 Infection in a Young Patient with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy
Coronavirus disease of 2019 (COVID-19) has currently reached pandemic levels and neurological manifestations, including stroke as the initial presentation, have been increasingly recognized (1-3). Majority of the reported ischemic strokes are large vessel occlusion or embolic appearing strokes and are frequently described in critically ill patients with severe COVID-19 disease (2), but small ischemic strokes have also been reported (4). Recently, stroke as the presenting symptom in younger patients ( (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 18, 2020 Category: Neurology Authors: Gabriela Trifan, Maureen Hillmann, Fernando D. Testai Source Type: research

Chronic Kidney Disease and Clinical Outcomes in Patients with Intracerebral Hemorrhage
The influence of chronic kidney disease (CKD) on functional outcome in intracerebral hemorrhage (ICH) is scarcely investigated and reported findings are conflicting mostly because of nonaccounting for imbalances. Aim of the present study was to determine the impact of CKD on functional long-term outcome in ICH-patients. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 15, 2020 Category: Neurology Authors: Vanessa D. Beuscher, Maximilian I. Spr ügel, Stefan T. Gerner, Jochen A. Sembill, Dominik Madzar, Caroline Reindl, Hannes Lücking, Stefan Lang, Philip Hoelter, Joji B. Kuramatsu, Hagen B. Huttner Source Type: research

Multicenter, retrospective analysis of endovascular treatment for acute ischemic stroke in nonagenarians
Background: With the increasing age of acute stroke patients being admitted to hospitals, more data are needed on indications, complications and outcome of endovascular treatment (EVT) in the very elderly. Methods: Retrospective observational study with data collection from Belgian, Swiss, Canadian comprehensive stroke centers and Swedish EVT National database. All patients with acute ischemic stroke were eligible if aged older than or ≥90 years and treated with EVT ± pretreatment with intravenous thrombolysis (IVT). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 15, 2020 Category: Neurology Authors: Helena Janssen, Stefania Nannoni, Olivier Francois, Tom Dewaele, Sofie De Blauwe, Geert Vanhooren, Johan Ghekiere, Joost Kager, Andr é Peeters, Pierre Goffette, Frank Hammer, Thierry Duprez, Jelle Demeestere, Robin Lemmens, Sandra Cornelissen, Sam Heye, Source Type: research

Effects of Oral Antiplatelet Agents and Tirofiban on Functional Outcomes of Patients with Non-Disabling Minor Acute Ischemic Stroke
Over half of patients with acute ischemic stroke present with minor neurologic deficits. We investigated the effects of oral antiplatelet agents vs. tirofiban, a highly selective GP IIb/IIIa antiplatelet drug, on functional outcomes of stroke patients with non-disabling neurologic deficits. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 15, 2020 Category: Neurology Authors: Huan Wang, Xiaoshu Li, Chengchun Liu, Shuhan Huang, Chunrong Liang, Meng Zhang Source Type: research

Dapsone prolong delayed excitotoxic neuronal cell death by interacting with proapoptotic/survival signaling proteins
Dapsone prevents ischemic injury, inhibits apoptosis and shows functional improvement post-ischemia. However, its effect on proapoptotic or survival proteins in delayed ischemia remains unclear. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 15, 2020 Category: Neurology Authors: Ashutosh Mahale, Rakesh Kumar, Lopmudra P. Sarode, Sukanya Gakare, Anand Prakash, Rajesh R. Ugale Source Type: research

miR-134-5p inhibition reduces infarct-induced cardiomyocyte apoptosis via Creb1 upregulation
Patients presenting with symptoms related to acute coronary syndrome account for a total of 5% to 10% of all visits to the emergency department.1,2 However, the ability to accurately diagnose and treat patients that present with acute myocardial infarction (AMI) is often challenging and time-consuming. Following AMI-induced ischemia, many pathological changes occur to the cardiomyocytes, including reactive oxygen species (ROS) overload, calcium dyshomeostasis, metabolic dysfunction, and cell death. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 15, 2020 Category: Neurology Authors: Jibin Yang, Shiwen Liu, Hao Wang, Ying Liu, Yong Liu Source Type: research

Carotid Calcium Volume and Stenosis after Stent Implantation
Internal carotid artery (ICA) stenosis could be treated with stent placement. It was hypothesized that calcium amount could be predictive of vessel stenosis after stent placement. We utilised computed tomography (CT) angiography to quantify volume of calcium material in bulbar ICA. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 15, 2020 Category: Neurology Authors: Johannes Sebastian Mutzenbach, Lukas Machegger, Luis Rafael Moscote-Salazar, Monika Killer-Oberpfalzer, Erasmia M üller-Thies-Broussalis, Slaven Pikija Source Type: research

Stereotactic Radiosurgery for Brain Arteriovenous Malformations: Evaluation of Obliteration and Review of Associated Predictors
High arteriovenous malformation (AVM) obliteration rates have been reported with stereotactic radiosurgery (SRS), and multiple factors have been found to be associated with AVM obliteration. These predictors have been inconsistent throughout studies. We aimed to analyze our experience with linear accelerator (LINAC)-based SRS for brain AVMs, evaluate outcomes, assess factors associated with AVM obliteration and review the various reported predictors of AVM obliteration. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 15, 2020 Category: Neurology Authors: Badih J. Daou, Gregory Palmateer, B. Gregory Thompson, Cormac O. Maher, James A. Hayman, Kwok L. Lam, Daniel R. Wahl, Michelle Kim, Aditya S. Pandey Source Type: research

A novel model for predicting the outcome of intracerebral hemorrhage: Based on 1186 Patients
To establish a model for predicting the outcome according to the clinical and computed tomography(CT) image data of patients with intracerebral hemorrhage(ICH). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 15, 2020 Category: Neurology Authors: Xi-wu He, Ming-di Chen, Chao-nan Du, Kai Zhao, Ming-fei Yang, Qing-fang Ma Source Type: research

Differences in presenting symptoms of acute stroke among young and older adults
Prior studies demonstrated that young adults with stroke present later to medical attention, have lower initial NIHSS, and are frequently misdiagnosed as compared to older adults. We sought to assess potential differences in temporal and clinical characteristics of stroke symptoms between young (age 18 –50 years) and older adults (age> 50). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 15, 2020 Category: Neurology Authors: Haley E. Huggins, Merrill Brady, Jost-Price Emma, David E. Thaler, Lester Y. Leung Source Type: research

Association between Tooth Loss and Stroke: A Systematic Review
This systematic review aims to evaluate the association between tooth loss and stroke. The Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines were followed. The PECO strategy was used to limit the eligibility criteria. The following databases were used on searches: PubMed, Scopus, Web of Science, The Cochrane Library, LILACS and OpenGrey. We included observational studies performed in adults (Population), in which patients with tooth loss (Exposition) and patients without tooth loss (Comparison) were observed to investigate the association between tooth loss and stroke (Outcome). (Source:...
Source: Journal of Stroke and Cerebrovascular Diseases - July 15, 2020 Category: Neurology Authors: Nathalia Carolina Fernandes Fagundes, Roberta Souza D'Almeida Couto, Ana Paula Taborda Brand ão, Leidiane Alencar de Oliveira Lima, Leonardo de Oliveira Bittencourt, Renata Duarte de Souza-Rodrigues, Marco Aurelio M. Freire, Lucianne Cople Maia, Rafael R Tags: Review Article Source Type: research

Combined polymorphisms in genes encoding the inflammasome components NLRP3 and CARD8 confer risk of ischemic stroke in men
Stroke is a common medical emergency with high mortality. There are two types of stroke, namely, hemorrhagic stroke and ischemic stroke (IS), and 85 –90% of stroke cases are ischemic. Studies have confirmed that the nucleotide-binding domain (NOD)-like receptor protein 3 (NLRP3) inflammasome may be involved in activating the inflammation and pathophysiology of atherosclerosis as well as in mediating inflammatory injury during cerebral ischemia .1 (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 15, 2020 Category: Neurology Authors: Jie Lv, Xiaoshan Jiang, Jing Zhang, Xianghui Peng, Hongmei Lin Source Type: research

The Unmet Needs of Stroke Survivors and Stroke Caregivers: A Systematic Narrative Review
Stroke has been recognized as a factor that has contributed significantly to the mortality and morbidity in developing and non-developing countries.1 It has been documented that 15 million individuals suffer from stroke globally, in which 5  million patients die from stroke while another 5 million continue living with disability.2 Analysis from the Global Burden of Disease (GBD) Study 20163 demonstrated differences in the rise of stroke geographically. Specifically, the authors documented higher risk in stroke in East Asia, Central E urope and Eastern Europe. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 15, 2020 Category: Neurology Authors: N.S.M. Zawawi, N.A. Aziz, R. Fisher, K. Ahmad, M.F. Walker Source Type: research

Effects of gait exercise assist robot (GEAR) on subjects with chronic stroke: A randomized controlled pilot trial
Improvement of gait ability is one of the primary goals in stroke rehabilitation.1 As a result, defining more effective interventions for increasing gait ability after stroke is essential. In recent years, robotic rehabilitation has been attracting a great deal of attention as a method for improving gait ability after stroke all over the world. The updated Cochrane review has shown that electromechanical-assisted gait training in combination with physiotherapy improves the acquisition of independent walking compared to gait training without such devices. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 15, 2020 Category: Neurology Authors: Tomoyuki Ogino, Yoshihiro Kanata, Ryota Uegaki, Tatuya Yamaguchi, Katuhisa Morisaki, Shuhei Nakano, Kazuhisa Domen Source Type: research

Enhanced dispatch and rendezvous doubles the catchment area and number of patients treated on a mobile stroke unit
Mobile Stroke Units (MSUs) deliver acute stroke treatment on-scene in coordination with Emergency Medical Services (EMS). One criticism of the MSU approach is the limited range of a single MSU. The Houston MSU is evaluating MSU implementation, and we developed a rendezvous approach as an innovative solution to expand the range and number of patients treated. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 15, 2020 Category: Neurology Authors: Stephanie A Parker, Tessa Kus, Ritvij Bowry, Nicole Gutierrez, Chunyan Cai, Jose-Miguel Yamal, Suja Rajan, Mengxi Wang, Asha P Jacob, Christopher Souders, David Persse, James C Grotta Source Type: research

Predictive value of discharge destination for 90-day outcomes among ischemic stroke patients eligible for endovascular treatment: Post-hoc analysis of DEFUSE 3
The endovascular treatment (ET) for acute ischemic stroke (AIS) is increasing among eligible patients. To help address care quality, administrative data sets are utilized but do not usually include formal outcome scales. We explore the predictive ability of discharge destination from acute hospitalizations for long-term disability among AIS patients eligible for ET within a clinical trial. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 15, 2020 Category: Neurology Authors: Ganesh Asaithambi, Megan E. Tipps Source Type: research

Reversal strategies and outcomes in patients with atrial fibrillation and warfarin-associated intracranial hemorrhage
While anticoagulants are highly effective in preventing thromboembolism in atrial fibrillation (AF), they raise the risk of hemorrhage, which can be life-threatening especially in cases of intracranial hemorrhage (ICH). Warfarin-associated intraparenchymal hemorrhage (IPH) leads to death within 30 days in as many as 60% of cases while the other major category of ICH on warfarin, subdural hemorrhage (SDH), leads to death in approximately a quarter of cases.1 Managing these potentially devastating bleeds is an important consideration in treating patients on oral anticoagulant therapy. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 15, 2020 Category: Neurology Authors: Daniel E. Singer, Leila H. Borowsky, Susan Regan, Jong Woo Lee, Kristina Zint, Lionel Riou Franca, Joshua N. Goldstein Source Type: research

Use of statins for the secondary prevention of stroke: are we respecting the scientific evidences?
Background: Stroke accounts for approximately as 5.0% of disability-adjusted years of life and 10.0% of all deaths worldwide. Secondary stroke prevention in surviving individuals, which includes the use of statins, reduces atherothrombotic stroke recurrence, complications and mortality. The present study aimed to characterize the Brazilian population with stroke history and estimate the prevalence of statin use as secondary prevention.Methods: This is a population-based cross-sectional study conducted in Brazilian urban areas. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 15, 2020 Category: Neurology Authors: Jo ão Paulo Vilela Rodrigues, Lucas Borges Pereira, Maria Olívia Barboza Zanetti, Andréia Turmina Fontanella, Nereida Kilza da Costa Lima, Sotero Serrate Mengue, Leonardo Régis Leira Pereira Source Type: research

Transient Ischemic Attack: The Trend and Readmissions in the United States
: Transient ischemic attack (TIA) is a temporary event of neurological dysfunction. Patients with TIA may be discharged from the Emergency Department or following an observational admission since their symptoms have resolved. Some portion of these patients, however, return to the hospital due to various reasons. The aim of our study is to find the trend of TIA readmissions in the United States. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 15, 2020 Category: Neurology Authors: Jared Alexander Stowers, Tiffany Brown, Lee Albert Birnbaum, Ali Seifi Source Type: research

Triggering factors in non-traumatic intracerebral hemorrhage
Intracerebral hemorrhage (ICH), caused by a rupture of a brain artery into brain parenchyma, is the second most common form of stroke after ischemic stroke.1 Approximately 40% of the patients die within one month, and many remain with major disabilities.2 There is no effective medical or surgical treatment option, and those in clinical use are mainly supportive in nature, even though management in dedicated stroke units will likely reduce mortality and morbidity.3 Several chronic risk factors such as hypertension, older age, and high alcohol consumption have been shown to associate with ICH. (Source: Journal of Stroke and ...
Source: Journal of Stroke and Cerebrovascular Diseases - July 15, 2020 Category: Neurology Authors: Hanne Sallinen, Jukka Putaala, Daniel Strbian Source Type: research

Prospective investigation of cerebellar cognitive affective syndrome in a previously non-demented population of acute cerebellar stroke
In this prospective study, we aimed to investigate the presence and evolution of cerebellar cognitive affective syndrome in a cohort of isolated cerebellar stroke with no known cognitive or psychiatric impairment. We tried to distinguish the unconfounded effect of cerebellar lesions on neuropsychological processing. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 15, 2020 Category: Neurology Authors: Aslihan Taskiran-Sag, Handan Uzuncakmak Uyanik, Sadik Ahmet Uyanik, Nese Oztekin Source Type: research

Dabigatran-induced chronic progressive immune hemolytic anemia: A case report
We present a case of immune hemolytic anemia (IHA) due to dabigatran use in a 72-year-old male with NVAF. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 15, 2020 Category: Neurology Authors: Jin-Hong Gong, Guang-Jun Liu, Feng Zhou, Zhi-Qiang Sun Tags: Case Report Source Type: research

Characteristics of the carotid plaque in hypertensive patients with hyperhomocysteinemia using multimode ultrasound
In this study, the characteristics of carotid plaque in hypertensive patients with hyperhomocysteinemia were preliminarily studied by conventional ultrasound, contrast-enhanced ultrasound and virtual touch image quantification. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 15, 2020 Category: Neurology Authors: Zhifei Ben, Jue Wang, Jingyong Zhan, Xiujuan Li, Haidong Ruan, Saijun Chen Source Type: research

Early venous filling after reperfusion therapy in acute ischemic stroke
Early venous filling after endovascular mechanical thrombectomy in acute ischemic stroke (AIS) is a specific finding that may serve as a biomarker for intracranial hemorrhage. However, the pathophysiology of early venous filling and postoperative hemorrhage remains unclear.The aim of this study was to investigate correlation between early venous filling and various factors involving patient demographics and perioperative imaging. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 15, 2020 Category: Neurology Authors: Koji Shimonaga, Toshinori Matsushige, Hiroki Takahashi, Yukoshige Hashimoto, Tatsuya Mizoue, Chiaki Ono, Kaoru Kurisu, Shigeyuki Sakamoto Source Type: research

Correlation of Cerebral White Matter Lesions with Carotid Intraplaque Neovascularization assessed by Contrast-enhanced Ultrasound
In this study, we aim to evaluate the correlation of carotid IPN with cerebral WMLs. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 15, 2020 Category: Neurology Authors: Yuxuan Wang, Chao Jiang, Hui Huang, Niu Liu, Yi Wang, Zhaoyao Chen, Sen Liang, Minghua Wu, Yajun Jiang, Xiaoxiao Wang, Tingting Zhou, Hu Chen, Lin Zhang, Hui Li Source Type: research

Clinical outcomes of radiation-induced carotid stenosis: A systematic review and meta-analysis
Clinical outcomes of radiation-induced carotid stenosis are still unclear. Therefore, a systematic review and meta-analysis is needed to evaluate the short- and long-term outcomes after interventions to treat radiation-induced carotid stenosis. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 15, 2020 Category: Neurology Authors: Xiao Zhang, Yanying Yu, Kun Yang, Xuesong Bai, Tao Wang, Yao Feng, Ran Xu, Bin Yang, Xue Wang, Liqun Jiao, Yan Ma Source Type: research

The additional value of an algorithm for atrial fibrillation at the stroke unit
The objective of this study was to evaluate the additional diagnostic yield of an automated detection algorithm for AF on telemetric monitoring compared with routine detection by a stroke unit team in patients with recent ischemic stroke or TIA. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 15, 2020 Category: Neurology Authors: Gerlinde van der Maten, Gerben J.J. Plas, Matthijs F.L. Meijs, Paul J.A.M. Brouwers, Marjolein G.J. Brusse-Keizer, Heleen M. den Hertog Source Type: research

A Combined Approach to Intracerebral Hemorrhage: Intravenous Mesenchymal Stem Cell Therapy with Minimally Invasive Hematoma Evacuation
We report the first case of a patient with intracerebral hemorrhage (ICH) treated with combination MSC therapy and endoscopic hematoma evacuation. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 15, 2020 Category: Neurology Authors: Kaneez Zahra, Marion T. Turnbull, Abba C. Zubair, Jason L. Siegel, Carla P. Venegas-Borsellino, Rabih G. Tawk, William D. Freeman Tags: Case Report Source Type: research

Prognostic significance of pre-procedural prognostic nutritional index in patients with carotid artery stenting
Inflammation and malnutrition play a critical role in the outcomes of patients undergoing carotid artery stenting (CAS). Prognostic nutritional index (PNI) is commonly utilized to evaluate the peri-operative immune-nutritional status of patients undergoing colorectal cancer surgery and is independently associated with survival. We assessed the association between immune-nutritional status, indexed by PNI, and outcomes in CAS patients. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 15, 2020 Category: Neurology Authors: L ütfi Öcal, Ayhan Küp, Muhammed Keskin, Sinan Cerşit, Mehmet Çelik, Hayati Eren, Mustafa Ozan Gürsoy, Burak Öztürkeri, Bayram Öztürk, Mehmet Muhsin Turkmen Source Type: research

Effects of joint mobilization and stretching on the range of motion for ankle joint and spatiotemporal gait variables in stroke patients
Stroke patients have limited ranges of motion and gait disturbances due to neurological deficits and connective tissue changes. We assessed the effects of joint mobilization and active stretching on ankle joint range of motion and gait in stroke patients. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - July 15, 2020 Category: Neurology Authors: Kyun-Hee Cho, Shin-Jun Park Source Type: research