The duration of mediastinal chest tube drainage is not associated with postoperative pain or opioid consumption after cardiac surgery
Conclusions. The length of mediastinal chest tube drainage is not associated with the amount of postoperative pain or need for opioids after cardiac surgery. Male sex and aortic surgery were associated with higher and advanced age with lower overall opioid consumption.PMID:33622099 | DOI:10.1080/14017431.2021.1889655 (Source: Scandinavian Cardiovascular Journal)
Source: Scandinavian Cardiovascular Journal - February 24, 2021 Category: Cardiology Authors: Antti-Johannes Kalli Kati J ärvelä Niina Khan Ari Mennander Jahangir Khan Source Type: research

Post-exercise heart rate recovery and its speed are associated with cardiac autonomic responsiveness following orthostatic stress test in men.
Conclusion: HRR throughout the 1st to 5th min is positively correlated with parasympathetic responsiveness and overall cardiac autonomic modulation of HRV after the orthostatic stress test, and faster HRR is positively correlated with the relative degree of parasympathetic responsiveness after the active postural change at rest in healthy men. PMID: 33517781 [PubMed - as supplied by publisher] (Source: Scandinavian Cardiovascular Journal)
Source: Scandinavian Cardiovascular Journal - February 3, 2021 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

Outcome of valve sparing root replacement for diverse indications.
Conclusions. Mid-term outcomes of VSRR for patients with diverse indications in terms of survival, reoperation rate, and valve dysfunction rate were excellent in a center with a limited annual volume of VSSR. PMID: 33501855 [PubMed - as supplied by publisher] (Source: Scandinavian Cardiovascular Journal)
Source: Scandinavian Cardiovascular Journal - January 28, 2021 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

Impact of intraoperative neurologic deficits in carotid endarterectomy under regional anesthesia.
Conclusions. Neurologic deficits during carotid clamping are a predictor of perioperative stroke. Body mass index> 30 kg/m2, a lower degree of ipsilateral stenosis, and a higher degree of contralateral stenosis are independent predictors of neurologic deficits and, therefore, might play a role in the prevention of procedure-related stroke. PMID: 33487041 [PubMed - as supplied by publisher] (Source: Scandinavian Cardiovascular Journal)
Source: Scandinavian Cardiovascular Journal - January 27, 2021 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

Modified model for end-stage liver disease score predicts 30-day mortality in high-risk patients with acute pulmonary embolism admitted to intensive care units.
Authors: İdin K, Dereli S, Kaya A, Yenerçağ M, Yılmaz AS, Tayfur K, Gülcü O Abstract OBJECTIVES: The Model for End-stage Liver Disease excluding the international normalised ratio that is derived from prothrombin time which is calculated as a ratio of the patient's prothrombin time to a control prothrombin time standardized (MELD-XI) and modified MELD, which uses albumin in place of the international normalised ratio (MELD-Albumin) scores reflect liver and renal function and are predictors of mortality. However, their prognostic value in acute pulmonary embolism (APE) has not been studied. D...
Source: Scandinavian Cardiovascular Journal - January 27, 2021 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

Short term outcomes of rotational atherectomy versus orbital atherectomy in patients undergoing complex percutaneous coronary intervention: a systematic review and meta-analysis.
Conclusion: RA was associated with fewer vascular complications, but at a cost of higher incidence of myocardial infarction and higher fluoroscopy time compared with OA, at short term follow-up. OA is a safe and effective alternative for the management of CAC. PMID: 33461347 [PubMed - as supplied by publisher] (Source: Scandinavian Cardiovascular Journal)
Source: Scandinavian Cardiovascular Journal - January 21, 2021 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

Low diagnostic yield of ST elevation myocardial infarction amplitude criteria in chest pain patients at the emergency department.
Conclusions: In unselected chest pain patients at the emergency department, the diagnostic yield of both conventional and extended ECG criteria for ST-elevation myocardial infarction is low. The PPV can be increased by also considering reciprocal ST depression. PMID: 33461362 [PubMed - as supplied by publisher] (Source: Scandinavian Cardiovascular Journal)
Source: Scandinavian Cardiovascular Journal - January 21, 2021 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

Satisfaction with life and SF-36 vitality predict risk of ischemic heart disease: a prospective cohort study.
Conclusion. Our study indicates that both psychological and health-related components of wellbeing are important in relation to ischemic heart disease. PMID: 33461364 [PubMed - as supplied by publisher] (Source: Scandinavian Cardiovascular Journal)
Source: Scandinavian Cardiovascular Journal - January 21, 2021 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

Clinical outcome of cardiac resynchronization therapy in patients randomized to an active fixation bipolar left ventricular lead versus a passive quadripolar lead.
Conclusions: There were no significant differences between the active fixation group of patients and the quadripolar group of patients concerning improvement in echocardiographic parameters or clinical symptoms. ClinicalTrials.gov number, NCT04632472. PMID: 33426938 [PubMed - as supplied by publisher] (Source: Scandinavian Cardiovascular Journal)
Source: Scandinavian Cardiovascular Journal - January 13, 2021 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

β1-Adrenoceptor antibodies induce PPCM via inhibition of PGC-1α related pathway.
CONCLUSIONS: The results suggested that the symptoms of PPCM that appeared in autoimmune perinatal rats may be due to the increase of β1AR antibodies, which inhibited the pathway associated with peroxisome PGC-1α. PMID: 33412941 [PubMed - as supplied by publisher] (Source: Scandinavian Cardiovascular Journal)
Source: Scandinavian Cardiovascular Journal - January 10, 2021 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

The outcome of a preoperative one-minute sit-to-stand test is associated with ventilation time after cardiac surgery.
Conclusions. STST is a short and practical physical performance test that could enable a better prediction of the postoperative course after cardiac surgery. Patients with lower preoperative STST performance may require longer postoperative artificial ventilation, as they may present worse in some parameters of pulmonary functions and quality of life. However, these findings must be corroborated in larger studies. PMID: 33356620 [PubMed - as supplied by publisher] (Source: Scandinavian Cardiovascular Journal)
Source: Scandinavian Cardiovascular Journal - December 29, 2020 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

Transcatheter versus surgical aortic valve replacement in patients with chronic obstructive pulmonary disease.
Conclusions. In patients with COPD, TAVI was associated with reduced early mortality, while midterm mortality appeared similar, as compared with SAVR. PMID: 33356924 [PubMed - as supplied by publisher] (Source: Scandinavian Cardiovascular Journal)
Source: Scandinavian Cardiovascular Journal - December 29, 2020 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

Does the left circumflex coronary artery location impact on the success of chronic total occlusion recanalization? A single-center cohort study.
Authors: Hagnäs MJ, Venuti G, Castellana C, Piedimonte G, Ferrarotto L, Mäkikallio T, Capodanno D, Tamburino C, La Manna A Abstract We sought to determine whether the chronic total occlusions (CTO) recanalization results differ between circumflex artery (CX) and other coronary arteries in our center. The study dataset encompassed 428 consecutive procedures. J-CTO score was highest in the right coronary artery (RCA) and lowest in CX lesions. After adjusting for the J-CTO score, age, body mass index, baseline creatinine, diabetes, dyslipidemia and hypertension the odds ratio for procedural success in CX com...
Source: Scandinavian Cardiovascular Journal - December 19, 2020 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

Differential expression of lncRNAs in hypertension-induced pericytes.
Authors: Wu Q, Yuan X, Zhang H, Xiu R Abstract Pericytes facilitate vessel maturation and endothelial barrier functions closely related with the pathogenesis of organ damage from cardiovascular and cerebrovascular diseases such as hypertension. We used a computational-based strategy to first screen for differentially expressed genes and lncRNAs and characterized associations between lncRNAs of microvascular pericytes and hypertension. In total, 22 lncRNAs were upregulated and 46 were downregulated in the rats afflicted with spontaneous hypertension. Expression profiles for lncRNAs were significantly altered in the ...
Source: Scandinavian Cardiovascular Journal - December 9, 2020 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

Challenges in coronary heart disease prevention - experiences from a long-term follow-up study in Norway.
Authors: Sverre E, Peersen K, Perk J, Husebye E, Gullestad L, Dammen T, Otterstad JE, Munkhaugen J Abstract Objective. To determine longitudinal changes in lifestyle behaviour and lipid management in a chronic coronary heart disease (CHD) population. Design. A multi-centre cohort study consecutively included 1127 patients at baseline in 2014-2015, on average 16 months after a CHD event. Data were collected from hospital records, a questionnaire and clinical examination. Seven hundred and seven of 1021 eligible patients participated in a questionnaire-based follow-up in 2019. Data were analysed with univariat...
Source: Scandinavian Cardiovascular Journal - December 5, 2020 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

A novel marker for predicting severity of acute pulmonary embolism: systemic immune-inflammation index.
Authors: Gok M, Kurtul A Abstract BACKGROUND: Systemic pro-coagulatory and pro-inflammatory factors are critical factors in acute pulmonary embolism (APE). Recently the systemic immune-inflammation index (SII) has emerged as a new inflammatory and prognostic marker. We aimed to determine whether there is a relationship between SII and the severity of the APE. Methods. A total of 442 patients with APE, 202 women (45.7%) with an average age of 64 ± 16, were included in this retrospective observational study. APE severity was classified as massive (high risk), submassive (intermediate risk), and n...
Source: Scandinavian Cardiovascular Journal - December 4, 2020 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

Sex- and age-related differences in the predictive capability of circulating biomarkers: from the MONICA 10 cohort.
Authors: Frary CE, Biering-Sørensen T, Nochioka K, Blicher MK, Olesen TB, Stidsen JV, Greve SV, Vishram-Nielsen JKK, Rasmussen SL, Eugen-Olsen J, Olsen MH, Pareek M Abstract OBJECTIVES: The purpose of this study was to assess whether high-sensitivity C-reactive protein (hs-CRP), N-terminal pro-brain natriuretic peptide (NT-proBNP), and soluble urokinase plasminogen activator receptor (suPAR) differed in their ability to predict cardiovascular outcomes beyond traditional risk factors in younger and older men and women without known cardiovascular disease. Design. Prospective population-based cohort study of 1...
Source: Scandinavian Cardiovascular Journal - December 2, 2020 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

Preoperative atrial fibrillation in association with reduced haemoglobin predicts increased 30-d mortality after cardiac surgery.
Authors: Räsänen J, Juutilainen A, Halonen J Abstract OBJECTIVES: Atrial fibrillation is the most common arrhythmia occurring after cardiac surgery. Less attention has been focused on preoperative atrial fibrillation and anaemia as risk factors for mortality after cardiac surgery. The aim of this study was to determine preoperative risk factors for 30-d mortality after open-heart surgery. Design. The study population consisted of 2015 patients (73.4% men; mean age 68 years) undergoing coronary artery bypass grafting (CABG) (52.0%), aortic valve replacement (AVR) (18.6%), AVR and CABG (10.0%), mitral ...
Source: Scandinavian Cardiovascular Journal - November 19, 2020 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

St. Thomas and del Nido cardioplegia are superior to Custodiol cardioplegia in a rat model of donor heart.
Authors: Karduz G, Yaman MO, Altan M, Sahin G, Toraman F, Aksu U Abstract OBJECTIVES: Cardiac transplantation is an effective treatment for advanced heart disease and protection of the donor organ is directly associated with post-transplantation outcomes. Cardioplegic strategies intend to protect the donor heart against ischemic injury during transplantation procedures. In our study, the effects of three different cardioplegia solutions were evaluated in a rat heart donor model in terms of cellular base. Design. Cardioplegia solutions as St. Thomas, del Nido or Custodiol were administered to male Wistar albino rats...
Source: Scandinavian Cardiovascular Journal - November 18, 2020 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

Biatrial ablation vs. Pulmonary vein isolation in atrial fibrillation patients undergoing cardiac surgery: a retrospective study.
This study aimed to compare postoperative rhythm outcomes and pacemaker implantation rates after biatrial ablation or pulmonary vein isolation (PVI) concomitantly with other cardiac surgery. Design: In a retrospective study, we included patients who underwent biatrial ablation or PVI. Postoperative rhythm status was assessed by Holter monitoring. All data on outcomes and patient characteristics were collected retrospectively. Results: In total 109 patients had a biatrial procedure whereas 337 had PVI performed. In patients with persistent/long-standing persistent atrial fibrillation, freedom from atrial fibrillation was mo...
Source: Scandinavian Cardiovascular Journal - November 12, 2020 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

Validation of the cardiovascular risk model NORRISK 2 in South Asians and people with diabetes.
Conclusions. The NORRISK 2-SADia model improved predictions of CVD substantially in South Asians, whose risks were underestimated by the NORRISK 2 model. The NORRISK 2-SADia model may facilitate more intense preventive measures in this high-risk population. PMID: 33073627 [PubMed - as supplied by publisher] (Source: Scandinavian Cardiovascular Journal)
Source: Scandinavian Cardiovascular Journal - October 20, 2020 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

Repeat pulmonary vein isolation in patients with atrial fibrillation: low ablation index is associated with increased risk of recurrent arrhythmia.
Conclusions. The risk of recurrence is higher in patients with ablations performed with low levels of AI and in patients with reconnection to up to two PVs. Our data may indicate the need for higher target levels of AI during repeat PVI than normally used during de-novo PVI. PMID: 33073633 [PubMed - as supplied by publisher] (Source: Scandinavian Cardiovascular Journal)
Source: Scandinavian Cardiovascular Journal - October 20, 2020 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

Matrix metalloproteinase-12 cleaved fragment of titin as a predictor of functional capacity in patients with heart failure and preserved ejection fraction.
Conclusions. In this sample of stable and symptomatic HFpEF patients, higher serum levels of TIM identified patients with worse functional status. PMID: 33030056 [PubMed - as supplied by publisher] (Source: Scandinavian Cardiovascular Journal)
Source: Scandinavian Cardiovascular Journal - October 10, 2020 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

Cardiovascular risk unawareness is common in individuals admitting to cardiology outpatient clinics in Turkey: the CVSCORE-TR study.
Conclusions. Only one-thirds of the sample was aware of their calculated risk for cardiovascular mortality and risk underestimation was the most common mode of risk unawareness, prompting concerns on the possible impact of the latter on adherence to the strategies aimed to reduce cardiovascular risk. PMID: 32998573 [PubMed - as supplied by publisher] (Source: Scandinavian Cardiovascular Journal)
Source: Scandinavian Cardiovascular Journal - October 3, 2020 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

Outcome of hybrid compared to conventional revascularization in multivessel coronary artery disease.
Conclusions. HMR was not superior with respect to MACCE compared with CABG and PCI. It may, however, represent a safe alternative to conventional revascularization treatment considering the specific procedure-associated morbidity. PMID: 32998590 [PubMed - as supplied by publisher] (Source: Scandinavian Cardiovascular Journal)
Source: Scandinavian Cardiovascular Journal - October 3, 2020 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

Hospital discharge register data on non-ST-elevation and ST-elevation myocardial infarction in Finland; terminology and statistical issues on validity and agreement to avoid misinterpretation.
Authors: Sabour S PMID: 32998593 [PubMed - in process] (Source: Scandinavian Cardiovascular Journal)
Source: Scandinavian Cardiovascular Journal - October 3, 2020 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

Reorganization of heart failure management and improved outcome - the 4D HF Project.
Authors: Matan D, Löfström U, Corovic Cabrera C, Eriksson B, Ekström M, Hage C, Ljunggren G, Lyngå P, Wallén H, Knudsen Malmqvist K, Linde C, Persson H Abstract OBJECTIVES: Heart failure (HF) management is suboptimal in Sweden despite available evidence-based guidelines. To improve HF treatment, a comprehensive HF management program (4D project) was implemented in the Stockholm County (>2.1 million inhabitants). Design. A standardized care program centralized at five hospital-based HF clinics was implemented in 2014-2017. We registered from 2012 to 2017: (1) numbers of referrals and v...
Source: Scandinavian Cardiovascular Journal - September 26, 2020 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

No effects of cardiac resynchronization therapy and right ventricular pacing on the right ventricle in patients with heart failure and atrial fibrillation.
Authors: Majos-Karwacka E, Kraska A, Kowalik I, Smolis-Bak E, Lipiec P, Kasprzak J, Szwed H, Dabrowski R Abstract BACKGROUND: The right ventricle (RV) function is crucial in heart failure with reduced ejection fraction (HFrEF), especially in patients with atrial fibrillation (AF). Aims. To assess the RV structure and function in patients with HFrEF, permanent atrial fibrillation (AF), cardiac resynchronization therapy (CRT) and RV pacing (RVp) with two- and three-dimensional echocardiography. Methods. Patients with ischemic HFrEF (NYHA II-III; LVEF ≤40%) were enrolled. The studied groups were: sinus rhythm (SR, ...
Source: Scandinavian Cardiovascular Journal - September 23, 2020 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

Lower ST-elevation myocardial infarction incidence during COVID-19 epidemic in Northern Europe.
Authors: Piuhola J, Kerkelä R, Laine M, Andersen GØ, Ērglis A, Kumsārs I, Thuesen L, Sinisalo J, Niemelä M, Junttila MJ Abstract We compared the ST elevation myocardial infarction (STEMI) incidence during COVID-19 pandemic (March 2020) to January-February 2020 and to same time period in earlier years 2017-2019 in five Nordic-Baltic tertiary centers. During 2017-2019, there were no marked differences in STEMI incidence between January, February and March. During 2020, there was an average drop of 32% in STEMI incidence in March. The isolation measures may decrease the risk for respiratory virus in...
Source: Scandinavian Cardiovascular Journal - September 20, 2020 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

Detection of silent cerebral microcirculatory abnormalities in patients with manifest ischemic coronary disease: a perfusion brain MRI study combined with dipyridamole stress.
CONCLUSIONS: Intravenous DP changed the CBV accompanied by a systemic elevation of L-arginine: this indicates a direct vasorelaxing effect on brain vessels, and an indirect vasodilator effect through L-arginine release presumably via NO. In areas with decreased CBV before DP, such double effects caused transient neurological symptoms presumably due to steal phenomenon. Therefore, intravenous DP may have a potential to identify patients with high risk for cerebral ischemia. PMID: 32945202 [PubMed - as supplied by publisher] (Source: Scandinavian Cardiovascular Journal)
Source: Scandinavian Cardiovascular Journal - September 20, 2020 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

Does a bedside echo prior to primary percutaneous coronary intervention alter interventional strategy?
Authors: Bharucha A, Kanyal R, MacCarthy P PMID: 32930039 [PubMed - as supplied by publisher] (Source: Scandinavian Cardiovascular Journal)
Source: Scandinavian Cardiovascular Journal - September 17, 2020 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

Implantable cardiac devices in adult patients with repaired tetralogy of Fallot.
Conclusion: The prevalence of devices in our population, representing a multicenter register cohort, was lower than previously reported, especially regarding ICD. This can be due to differences in treatment traditions with regard to ICD in this population, but it may also be that previous studies have reported selected patients with more severe disease. PMID: 32672076 [PubMed - as supplied by publisher] (Source: Scandinavian Cardiovascular Journal)
Source: Scandinavian Cardiovascular Journal - July 18, 2020 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

Clinical presentation and outcomes in women and men with advanced heart failure.
Authors: Vishram-Nielsen JKK, Deis T, Rossing K, Wolsk E, Alba AC, Gustafsson F Abstract OBJECTIVE: To examine clinical characteristics and outcomes in women and men referred for advanced heart failure (HF) therapies such as left ventricular assist device (LVAD) or heart transplantation (HTx). Design: A retrospective study of 429 (23% women) consecutive adult HF patients not on inotropic or mechanical circulatory support with left ventricular ejection fraction ≤45% referred for assessment of advanced HF therapies at a single tertiary institution between 2002 and 2016. Clinical characteristics and outcomes were c...
Source: Scandinavian Cardiovascular Journal - July 17, 2020 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

Answer to Dr. Sabours letter about our article 'the validity of hospital discharge register data on non-ST-elevation and ST-elevation myocardial infarction in Finland'.
Authors: Okkonen M, Havulinna AS, Ukkola O, Salomaa V PMID: 32597231 [PubMed - as supplied by publisher] (Source: Scandinavian Cardiovascular Journal)
Source: Scandinavian Cardiovascular Journal - July 1, 2020 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

The combination of neutrophil-to-lymphocyte ratio and platelet correlation parameters in predicting the no-reflow phenomenon after primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction.
Conclusions: The NLR, MPV and PDW are all associated with the no-reflow. However, there is no significant difference in the predictive value of these indicators. The combinations of NLR and platelet-associated parameters also do not show a better predictive value than NLR alone. PMID: 32597237 [PubMed - as supplied by publisher] (Source: Scandinavian Cardiovascular Journal)
Source: Scandinavian Cardiovascular Journal - July 1, 2020 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

Plasma insulin-like growth factor binding protein 1 in pulmonary arterial hypertension.
Authors: Bouzina H, Hesselstrand R, Rådegran G Abstract Background: Beside the pulmonary vasoconstriction observed in pulmonary arterial hypertension (PAH), severe proliferative and antiapoptotic cellular phenotypes result in vascular remodelling. Many recent findings indicate similarities between PAH and tumour pathology. For instance, insulin-like growth factor (IGF)-1 signalling, which is known to promote tumour development, is implicated in PAH. Higher circulating IGF binding protein (IGFBP)-1 levels are associated with worse survival in PAH. The present study aimed to investigate the relationship between...
Source: Scandinavian Cardiovascular Journal - July 1, 2020 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

Direct angiography demonstrates equal 8-12 years patency rates of radial artery and saphenous vein grafts.
Conclusion: The high long-term patency rate of saphenous vein grafts does not support a preferential use of the radial artery as a coronary artery bypass conduit. Clinical registration number: ISRCTN23118170. PMID: 32603197 [PubMed - as supplied by publisher] (Source: Scandinavian Cardiovascular Journal)
Source: Scandinavian Cardiovascular Journal - July 1, 2020 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

Percutaneous coronary intervention in the very elderly with NSTE-ACS: the randomized 80+ study.
Conclusion: In the very elderly with NSTE-ACS, we did not find any significant difference in MACCE between invasive and conservative treatment groups at 12-month follow-up, possibly due to small sample size. ClinicalTrials.gov: NCT02126202. PMID: 32586153 [PubMed - as supplied by publisher] (Source: Scandinavian Cardiovascular Journal)
Source: Scandinavian Cardiovascular Journal - June 28, 2020 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

Risk stratification in chronic thromboembolic pulmonary hypertension predicts survival.
Conclusion. The ESC/ERS risk assessment tool identifies CTEPH patients with reduced survival. Furthermore, PEA improves survival markedly independently of risk group and age. Take home message: The ESC/ERS risk stratification for PAH predicts survival also in CTEPH patients, even when taking PEA into account. PMID: 32586166 [PubMed - as supplied by publisher] (Source: Scandinavian Cardiovascular Journal)
Source: Scandinavian Cardiovascular Journal - June 28, 2020 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

Impact of allograft ischemic time on long-term survival in lung transplantation: a Swedish monocentric study.
Authors: Ghaidan H, Fakhro M, Lindstedt S Abstract Purpose: The influence of allograft ischemic time (IT) on short- and long-term mortality remains under debate in lung transplantation (LTx). Due to a scarcity in donors, better understanding of IT might improve the outcome after LTx. Methods: Between January 1990 and June 2016; 307 patients underwent LTx at Lund university hospital, Sweden. The end-point used was death/Re-LTx assessed by Cox regression and Kaplan-Meier survival. Results: Kaplan-Meier survival for mean IT (min) between subgroups ≤120, 121-240, 241-360 and 361+ showed significant difference for pa...
Source: Scandinavian Cardiovascular Journal - June 25, 2020 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

Observations on changes in ventricular repolarization following four weeks of exercise training in chronic heart failure patients.
Authors: Caru M, Gravel H, Pathak A, Bousquet M, Galinier M, Jacquemet V, Curnier D Abstract Objective: The aim of this study was to investigate the effects of exercise training on ventricular repolarization dynamicity and heart rate variability in chronic heart failure patients.Design: A total of 22 chronic heart failure patients with reduced ejection fraction in sinus rhythm were included in the study. The patients were in NYHA classes II-III with an ejection fraction of 29.7 ± 7.7%. Before and after 4 weeks of aerobic exercise training, all patients performed a cardiopulmonary exercis...
Source: Scandinavian Cardiovascular Journal - June 25, 2020 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

Heart failure etiology and risk of right heart failure in adult left ventricular assist device support: the European Registry for Patients with Mechanical Circulatory Support (EUROMACS).
Conclusions: Patients with non-ischemic HF undergoing LVAD had an increased incidence of early RVF compared to patients with ischemic HF in a large European population. During follow-up after discharge 14% patients developed RVF. We recommend HF etiology to be considered in identifying patients who are at risk for postoperative RVF after LVAD implantation. PMID: 32552049 [PubMed - as supplied by publisher] (Source: Scandinavian Cardiovascular Journal)
Source: Scandinavian Cardiovascular Journal - June 21, 2020 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

The quest for a radial lounge: StatSeal ™ reduces transradial coronary angiography turn-around time and cost.
The quest for a radial lounge: StatSeal™ reduces transradial coronary angiography turn-around time and cost. Scand Cardiovasc J. 2020 Jun 11;:1-2 Authors: Galusko V, Protty M, Gilchrist W, Bharucha A, Bundhoo S, Cullen J PMID: 32525414 [PubMed - as supplied by publisher] (Source: Scandinavian Cardiovascular Journal)
Source: Scandinavian Cardiovascular Journal - June 12, 2020 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

Anti-inflammatory effects of non-statin low-density lipoprotein cholesterol-lowering drugs: an unused potential?
Conclusion. This topic adds an interesting piece to the puzzle of atherosclerosis, indicating that PCSK9 inhibition, BAS and ezetimibe all affect thromboinflammation. PMID: 32500743 [PubMed - as supplied by publisher] (Source: Scandinavian Cardiovascular Journal)
Source: Scandinavian Cardiovascular Journal - June 7, 2020 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

Association between lipid fractions and age of first myocardial infarction.
Conclusions. LDL-C is the lipid fraction strongest associated with younger age of presentation of first MI. These results support the importance of controlling and treating LDL-C in prevention of premature MI. PMID: 32483990 [PubMed - as supplied by publisher] (Source: Scandinavian Cardiovascular Journal)
Source: Scandinavian Cardiovascular Journal - June 4, 2020 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

Three-dimensional versus two-dimensional transthoracic echocardiography for left ventricular outflow tract measurements in severe aortic stenosis. A cross-sectional study using computer tomography and Haegar sizers as reference.
Conclusions. 2D TTE showed better feasibility and inter-observer variability in measurements of LVOT than 3D TTE. Both echocardiographic methods underestimated LVOT area compared to CT and Haegar sizers. These observations suggest that 2D TTE is still preferable to 3D TTE in the assessment of aortic stenosis. PMID: 32408833 [PubMed - as supplied by publisher] (Source: Scandinavian Cardiovascular Journal)
Source: Scandinavian Cardiovascular Journal - May 16, 2020 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

SuPAR is associated with death and adverse cardiovascular outcomes in patients with suspected coronary artery disease.
Conclusion: These results validate previous findings that demonstrate suPAR to be an independent predictor of death/MI in patients with suspected or known CAD, however suPAR was not associated with presence or extent of CAD in our cohort. Probably because suPAR reflects end organ damage rather than the degree of atherosclerosis.BRIEF SUMMARY: We demonstrate that the inflammatory biomarker soluble urokinase plasminogen activator receptor is an independent predictor of death/myocardial infarction in patients with suspected or known coronary artery disease, but is not associated with the presence or severity of coronary arter...
Source: Scandinavian Cardiovascular Journal - May 15, 2020 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

Secondhand cigarette smoke induces increased expression of contractile endothelin receptors in rat coronary arteries via a MEK1/2 sensitive mechanism.
Conclusions: Taken together, our data show that SHS increases contractile ET receptors and MEK1/2 pathway inhibitor offsets SHS exposure-induced ETA and ETB receptor upregulation in rat coronary arteries. PMID: 32400208 [PubMed - as supplied by publisher] (Source: Scandinavian Cardiovascular Journal)
Source: Scandinavian Cardiovascular Journal - May 15, 2020 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

Serum albumin, cardiometabolic and other adverse outcomes: systematic review and meta-analyses of 48 published observational cohort studies involving 1,492,237 participants.
Conclusions. Elevated levels of serum albumin are associated with reduced risk of vascular outcomes, all-cause mortality, certain cancers, and fracture. Inconsistent findings for T2D may be attributed to selective reporting by studies. Further research is needed to assess any potential causal relevance to these findings and the role of serum albumin concentrations in disease prevention.Systematic review registration: PROSPERO 2019: CRD42019125869. PMID: 32378436 [PubMed - as supplied by publisher] (Source: Scandinavian Cardiovascular Journal)
Source: Scandinavian Cardiovascular Journal - May 9, 2020 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research