Episodic gaze deviation in multiple sclerosis – Versive seizures or oculogyric crises?
We report a case of repeated drug induced OGCs in a 38 year old patient with secondary progressive multiple sclerosis. He was referred to our center for treatment of “intractable” epilepsy manifesting as episodic eye and head deviations with apparent unresponsiveness. In the epilepsy monitoring unit, ten typical spells were captured without epileptiform electroencephalographic correlates, but we discovered chronic exposure to metoclopramide. A diagnosis of OGC was suspected and Metoclopramide was stopped. This robustly improved the frequency of his spells. In a setting of usage of antidopaminergic medications...
Source: Journal of Clinical Neuroscience - October 14, 2018 Category: Neuroscience Source Type: research

A mini-open transspinous approach for resection of intramedullary spinal cavernous malformations
ConclusionA mini-open transspinous approach utilizing an expandable tubular retractor offers feasible less invasive alternative to provide dorsal midline access for the microsurgical resection of intramedullary spinal CMs. Larger case series or future randomized prospective trials are warranted to fully explore suitability of MIS techniques for the surgical management of intradural spinal cord vascular pathologies – such as CMs. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - October 14, 2018 Category: Neuroscience Source Type: research

Embryological basilar apex disposition as a risk factor of basilar apex aneurysm
Publication date: Available online 13 October 2018Source: Journal of Clinical NeuroscienceAuthor(s): Hidetoshi Matsukawa, Hiroyasu Kamiyama, Kosumo Noda, Nakao Ota, Osamu Takahashi, Takaharu Shonai, Sadahisa Tokuda, Rokuya TanikawaAbstractThe pathogenesis of basilar apex aneurysm (BAA) are still poorly understood. Embryologically, basilar apex anatomical disposition is formed by the fusion of both caudal internal carotid divisions on the midline. To compare basilar apex morphology by embryological classification among patients with BAAs, anterior circulation aneurysms (ACAs), and controls. Prospectively collected data of 4...
Source: Journal of Clinical Neuroscience - October 14, 2018 Category: Neuroscience Source Type: research

Surgical strategies and outcomes for intradural lipomas over the past 20 years
This report is, to the best of our knowledge, the most exhaustive analysis of cases of intradural lipomas and recurrences. The optimal treatment for lipoma necessitates both partial resection and duraplasty. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - October 14, 2018 Category: Neuroscience Source Type: research

Different clinicopathological features between Japanese siblings with facioscapulohumeral muscular dystrophy 2 with a novel nonsense SMCHD1 mutation (Arg552∗)
Publication date: Available online 13 October 2018Source: Journal of Clinical NeuroscienceAuthor(s): Yasuyuki Ohta, Koh Tadokoro, Ryo Sasaki, Yoshiaki Takahashi, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Jingwei Shang, Toru Yamashita, Yasushi Takehisa, Ichizo Nishino, Koji AbeAbstractFacioscapulohumeral muscular dystrophy (FSHD) 2 is caused by a combination of heterozygous structural maintenance of chromosomes flexible hinge domain containing 1 (SMCHD1) mutation plus DNA hypomethylation on D4Z4. Here we report two Japanese FSHD2 siblings (brother and sister) with a new SMCHD1 nonsense mutation (a heterogeneous c. 1654C...
Source: Journal of Clinical Neuroscience - October 14, 2018 Category: Neuroscience Source Type: research

Selective attention network impairment during the interictal period of migraine without aura
Publication date: Available online 13 October 2018Source: Journal of Clinical NeuroscienceAuthor(s): Mimi Han, Xunyao Hou, Song Xu, Yan Hong, Jian Chen, Yingjuan Ma, Shanjing Nie, Xueping LiuAbstractAttention deficits have been demonstrated in migraine patients during the interictal period, but these findings are not consistent across all studies. These inconsistencies may arise due to the different aspects of attention measured by various psychometric tests. Current theories divide attention into three separate domains subserved by separate networks: alerting, orienting, and executive control. The attention network test (...
Source: Journal of Clinical Neuroscience - October 14, 2018 Category: Neuroscience Source Type: research

Pathophysiology of corticobasal degeneration: Insights from neurophysiological studies
ConclusionsNeurophysiological techniques, in combination with neuroimaging studies, may shed light on the pathophysiological mechanisms of CBD. A better understanding of the disease processes may help clinicians to make a more accurate and early diagnosis. TMS, SEP, LLR, and co-evaluation of EEG and EMG can aid the in differentiation between CBD and other parkinsonism syndromes. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - October 14, 2018 Category: Neuroscience Source Type: research

Giant petrous internal carotid aneurysm causing epistaxis: A case report
We describe a 73-year-old man with a giant ICA aneurysm arising from the petrous portion and presenting as epistaxis. The patient had no history of trauma or clotting disorders. Computed tomography angiography demonstrated a giant petrous carotid aneurysm and erosion of a part of the left temporal bone. The patient was treated by trapping of the aneurysm with high-flow bypass using a radial artery. From an anatomical view point, rupture of ICA aneurysms of this portion might be caused by thinness of the bone partition between the ICA and the sphenoidal sinus. It should be noted that petrous carotid aneurysms are usually as...
Source: Journal of Clinical Neuroscience - October 14, 2018 Category: Neuroscience Source Type: research

Xanthogranuloma of the sellar region: A rare tumor. Case illustration and literature review
Publication date: Available online 14 October 2018Source: Journal of Clinical NeuroscienceAuthor(s): Giuseppe La Rocca, Mario Rigante, Marco Gessi, Quintino Giorgio D'Alessandris, Anna Maria Auricchio, Sabrina Chiloiro, Laura De Marinis, Liverana LaurettiAbstractXanthogranulomas are rare intracranial lesions with controversial etiology. The sellar location is exceedingly rare. Here we report a clinical case and a review of the English-language literature of histologically confirmed xanthogranulomas in order to furnish useful tools in diagnosis and management of this unusual disease.We performed an English-language literatu...
Source: Journal of Clinical Neuroscience - October 14, 2018 Category: Neuroscience Source Type: research

Toxic leukoencephalopathy with extrapyramidal dysfunction due to synthetic cannabinoids
We report a case of a woman who developed hyperreflexia, paratonia and cogwheel rigidity after consumption of synthetic cannabinoids. MR imaging demonstrated T2/FLAIR signal enhancement in the supratentorial white matter and globus pallidus internus. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - October 14, 2018 Category: Neuroscience Source Type: research

A new described mechanisms of intestinal glandular atrophy induced by vagal nerve/Auerbach network degeneration following subarachnoid hemorrhage: The first experimental study
Publication date: Available online 14 October 2018Source: Journal of Clinical NeuroscienceAuthor(s): Murtaza Cakir, Ali Ahiskalioglu, Erdem Karadeniz, Mehmet Dumlu Aydin, Umit Ali Malcok, Celaleddin Soyalp, Cagatay Calikoglu, Goksin Sengul, Sare Sipal, Ahmet Murat YayikAbstractStress ulcers is a trouble complication of subarachnoid hemorrhage (SAH). Although gastrointestinal ulcerations may be attributed to increased HCL secretion in SAH; the exact mechanism of that complication has not been investigated definitively. We studied if vagal network degeneration may cause intestinal atrophy following SAH. Study was conducted o...
Source: Journal of Clinical Neuroscience - October 14, 2018 Category: Neuroscience Source Type: research

Impact of small vessel disease on severity of motor and cognitive impairment in Parkinson’s disease
ConclusionsThis study demonstrates an association between SVD and motor impairment, and between vascular risk factors, particularly hypertension, and dementia in PD and highlights the need to manage vascular co-morbidities in PD patients. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - October 14, 2018 Category: Neuroscience Source Type: research

Activation of mirror neuron system during gait observation in sub-acute stroke patients and healthy persons
In this study, we sequentially enrolled five sub-acute stroke patients who had undergone gait training and nine healthy persons. We used fMRI to detect neuronal activation during gait observation. During the observation period in the stroke group, neural activity in the left inferior parietal lobule, right and left inferior frontal gyrus was significantly higher than during the rest period. In the healthy group, neural activity in the left inferior parietal lobule, left inferior frontal gyrus, left middle frontal gyrus, left superior temporal lobule and right and left middle temporal gyrus was significantly higher than dur...
Source: Journal of Clinical Neuroscience - October 12, 2018 Category: Neuroscience Source Type: research

Dramatic placebo effect of high frequency repetitive TMS in treatment of chronic migraine and medication overuse headache
Publication date: Available online 11 October 2018Source: Journal of Clinical NeuroscienceAuthor(s): Antonio Granato, Jacopo Fantini, Fabrizio Monti, Giovanni Furlanis, Sara Musho Ilbeh, Mauro Semenic, Paolo ManganottiAbstractChronic migraine (CM) is often associated with medication overuse headache (MOH). Few small trials have been conducted on Transcranial Magnetic Stimulation for CM treatment, but results are conflicting. Aim of the study was to investigate the effects of high frequency of repetitive Transcranial Magnetic Stimulation (hf-rTMS) in the dorsolateral prefrontal cortex combined with strongly suggesting to av...
Source: Journal of Clinical Neuroscience - October 11, 2018 Category: Neuroscience Source Type: research

Topically applied linoleic/linolenic acid for chronic migraine
We present a 45-year-old woman with chronic migraine without aura. Previous use of abortive or prophylactic therapies including sumatriptan, amitriptyline and topiramate had failed due to lack of efficacy or side-effects, especially vomiting. In search of a topical agent she performed an n-of-1 trial comparing application of linoleic acid (safflower oil) versus oleic acid (olive oil) for migraine relief. She found safflower oil to be effective. Topically applied safflower oil rich in linoleic and linolenic acids may offer a safe, easily applied, well-tolerated, effective anti-inflammatory approach for the prophylactic trea...
Source: Journal of Clinical Neuroscience - October 11, 2018 Category: Neuroscience Source Type: research

Changes in sexual functioning following traumatic brain injury: An overview on a neglected issue
Publication date: Available online 9 October 2018Source: Journal of Clinical NeuroscienceAuthor(s): Desiree Latella, Maria Grazia Maggio, Rosaria De Luca, Giuseppa Maresca, Denise Piazzitta, Francesca Sciarrone, Luigi Carioti, Alfredo Manuli, Placido Bramanti, Rocco Salvatore CalabroAbstractTraumatic brain injury (TBI) is any damage to the skull and/or the brain and its frameworks due to an external force. Following TBI, patients may report cognitive, physiological and psychosocial changes with a devastating impact on important aspects of the patient’s life, such as sexual functioning. Although sexual dysfunction (SD...
Source: Journal of Clinical Neuroscience - October 10, 2018 Category: Neuroscience Source Type: research

Predicting mortality in subarachnoid haemorrhage based on first-week routine blood tests
Publication date: Available online 9 October 2018Source: Journal of Clinical NeuroscienceAuthor(s): Bartosz Sokół, Norbert Wąsik, Barbara Więckowska, Witold Mańko, Robert Juszkat, Roman JankowskiAbstractAccurate prognosis of outcome in subarachnoid haemorrhage (SAH) identifies salvageable poor-grade patients. Widely available and independent prognostic factors are needed, thus value of six routine blood tests is established.Prospectively collected database of 116 aneurysmal SAH patients was reviewed for white blood cell (WBC) count and concentration of C-reactive protein (CRP), sodium, potassium, glucose and hae...
Source: Journal of Clinical Neuroscience - October 10, 2018 Category: Neuroscience Source Type: research

Near-infrared spectroscopy cerebral oximetry as a predictor of neurological intolerance during carotid artery stenting with proximal protection
Publication date: Available online 9 October 2018Source: Journal of Clinical NeuroscienceAuthor(s): Kohsuke Kakumoto, Kei Harada, Yukihiro Sankoda, Syunsuke Taniguchi, Kouzou FukuyamaAbstractCarotid artery stenting (CAS) with proximal protection can expose occlusion intolerance (OI) due to ipsilateral cerebral hemisphere hypoperfusion. Near-infrared spectroscopy (NIRS) cerebral oximetry can monitor regional cerebral oxygenation (rSO2) in the frontal lobes, and is used during CAS to predict cerebral blood flow insufficiency. The aim of this study was to evaluate rSO2 as a predictor of OI during CAS. We retrospectively exami...
Source: Journal of Clinical Neuroscience - October 10, 2018 Category: Neuroscience Source Type: research

Midterm outcome of thoracic disc herniations that were treated by microdiscectomy with bilateral decompression via unilateral approach
Publication date: Available online 9 October 2018Source: Journal of Clinical NeuroscienceAuthor(s): İsmail Yüce, Okan Kahyaoğlu, Halit Arda Çavuşoğlu, Halit Çavuşoğlu, Yunus AydınAbstractThoracic disc herniation (TDH) surgery carries risks of neurological worsening due to thoracic cord retraction injury. Multiple approaches have been developed aiming for resecting the disc herniations of the thoracic segment. We have conducted a prospective observational study to evaluate the mid-term outcome of thoracic microdiscectomy with bilateral decompression via a unilateral approach (BDUA). Patients were c...
Source: Journal of Clinical Neuroscience - October 10, 2018 Category: Neuroscience Source Type: research

Outcomes of tumour related epilepsy in a specialised epilepsy surgery unit
Publication date: Available online 9 October 2018Source: Journal of Clinical NeuroscienceAuthor(s): J. Kim, S. Radjadurai, Z. Rahman, K. Hitos, S. Ghattas, L. Gomes, C. Wong, A. Bleasel, M.A. DexterAbstractIntroductionSeizures are an important cause of morbidity in patients with low grade gliomas with approximately 40% of cases drug resistant. The pathogenesis is quite complex and poorly understood. The treatment aims vary between almost purely epilepsy considerations and those that are primarily oncologic.AimTo determine whether patients who present with seizures and are found to have a low grade glioma have better outcom...
Source: Journal of Clinical Neuroscience - October 10, 2018 Category: Neuroscience Source Type: research

Rapid eye movement behavior disorder in drug-naïve patients with Parkinson’s disease
This study found that RBD is not rare (19.62%) in Chinese drug-naïve PD patients and RBD has a great effect on quality of life. RBD in PD is related to cognitive dysfunction, anxiety and sleep disturbances. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - October 10, 2018 Category: Neuroscience Source Type: research

“Face of the giant panda” and hydrocephalus
Publication date: October 2018Source: Journal of Clinical Neuroscience, Volume 56Author(s): Martin W. Herklots, Cees C. Tijssen (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - October 9, 2018 Category: Neuroscience Source Type: research

Massive enlargement of all peripheral nerves
Publication date: October 2018Source: Journal of Clinical Neuroscience, Volume 56Author(s): Michael W.K. Fong, Lynette Masters, Shaun Watson (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - October 9, 2018 Category: Neuroscience Source Type: research

Metastatic craniocervical hemangiopericytoma presenting with hydrocephalus and papilledema – Case review
We report the unique case of a fifty-five-year-old male with recurrence of a previously resected craniocervical hemangiopericytoma presenting with obstructive hydrocephalus secondary to new metastatic cerebellar deposits. Emergent surgical resection of the cerebellar hemangiopericytomas was performed prior to adjuvant radiotherapy. Hemangiopericytomas are rare but important differentials for craniocervical junction lesions. Gross total resection remains the cornerstone of management with post-operative radiotherapy and chemotherapy as potential adjuncts. Tumors located in deep regions pose complex management challenges as ...
Source: Journal of Clinical Neuroscience - October 9, 2018 Category: Neuroscience Source Type: research

Fine margin between crossed sensory and contralateral sensory loss: A case report
We report this atypical sensory presentation and discuss its neuroanatomical correlation. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - October 9, 2018 Category: Neuroscience Source Type: research

Drug therapy for chronic subdural hematoma: Bench to bedside
Publication date: October 2018Source: Journal of Clinical Neuroscience, Volume 56Author(s): Shuanglin Fu, Fubin Li, Li BieAbstractChronic subdural hematoma (CSDH) is a common neurosurgical condition. Currently, surgery is the most effective medical intervention for treatment of this disorder. Because CSDH is an inflammatory angiogenic disease involving multifactorial mechanisms, a better understanding of CSDH pathogenesis should facilitate clinical management. Therefore, the purpose of this review is to describe recent progress in elucidation of molecular mechanisms causing CSDH and to summarize the body of knowledge gaine...
Source: Journal of Clinical Neuroscience - October 9, 2018 Category: Neuroscience Source Type: research

A single-institution prospective evaluation of a neuro-oncology multidisciplinary team meeting
Publication date: October 2018Source: Journal of Clinical Neuroscience, Volume 56Author(s): Malaka Ameratunga, Dorothea Miller, Wayne Ng, Mori Wada, Augusto Gonzalvo, Lawrence Cher, Hui K. GanAbstractMulti-disciplinary team meetings (MDTs) are considered essential to quality cancer care. For some malignancies, MDTs have been associated with improved outcomes, but data regarding the neuro-oncology MDT is limited. We prospectively described the MDT at our institution and evaluated its impact on clinical management. Cases were discussed amongst the treating team and a pre-MDT plan and reason for discussion (RFD) was documente...
Source: Journal of Clinical Neuroscience - October 9, 2018 Category: Neuroscience Source Type: research

The use of dietary supplements and perceived quality of life in patients with Parkinson’s disease
Publication date: October 2018Source: Journal of Clinical Neuroscience, Volume 56Author(s): Yassar AlamriAbstractPatients with chronic illnesses represent a segment of adults among whom intake of dietary supplements is particularly prevalent. Previous studies have shown that intake of different dietary supplements to improve perceived quality of life of patients with or without objective improvement in other physiological parameters. We recently conducted an open-label trial of blackcurrant anthocyanin supplementation in patients with PD. Participants were administered the PDQ-39 (a 39-item quality-of-life instrument) befo...
Source: Journal of Clinical Neuroscience - October 9, 2018 Category: Neuroscience Source Type: research

Outcome of newly diagnosed high risk medulloblastoma treated with carboplatin, vincristine, cyclophosphamide and etoposide
We report a revised chemotherapy protocol, replacing cisplatinum with carboplatin in newly diagnosed medulloblastoma cases. All 23 patients in this study had high risk medulloblastoma. Mean (SD) age was 9.5 ± 3.1 years. The 5-year progression free survival (PFS), 5-year overall survival (OS), and 10-year OS were 41.8 ± 12.2%, 60.0 ± 11.2%, and 48.0 ± 14.0 respectively. Most patients had grade 3–4 hematologic toxicity. Twelve patients had hearing tests, with 11 patients having grade 0 and 1 patient having grade 1 according to the Brock criteria. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - October 9, 2018 Category: Neuroscience Source Type: research

Meningioma in the elderly: Characteristics, prognostic factors, and surgical strategy
Publication date: October 2018Source: Journal of Clinical Neuroscience, Volume 56Author(s): Xiaochun Zhao, Dongxu Zhao, Yuxin Wu, Weizhen Gao, Hua Cui, Yong Wang, Peter Nakaji, Yinghui BaoAbstractMeningioma is one of the most common intracranial tumors. It has the features of benign and slow growing. We focused on the meningioma in the elderly, retrospectively analyzed 528 valid meningioma patients, including 115 (21.8%) patients older than 65 years old. The elderly patients were shown to have significantly larger tumor diameter (mean [±SD] 43.4 ± 18.0 mm) comparing with the young group (mean [±...
Source: Journal of Clinical Neuroscience - October 9, 2018 Category: Neuroscience Source Type: research

Clinical differences in patients with Parkinson’s disease according to tandem gait performance
In conclusion, tandem gait performance may be related to various clinical characteristics including cognitive function, mood, RBD, and freezing in patients with PD. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - October 9, 2018 Category: Neuroscience Source Type: research

A retrospective comparison of sac and lobe morphology between ruptured and unruptured intracranial aneurysms
Publication date: Available online 9 October 2018Source: Journal of Clinical NeuroscienceAuthor(s): Haydn Hoffman, Gentian Toshkezi, Amar Swarnkar, Grahame Gould, Lawrence S. Chin, Satish KrishnamurthyAbstractThere are few reliable morphologic indices to aid in the determination of an intracranial aneurysm’s rupture risk. We sought to characterize morphological characteristics of aneurysm sacs and their lobes that are associated with ruptured status at time of initial evaluation with diagnostic angiography. These factors could be associated with an aneurysm’s risk of rupturing. We retrospectively reviewed all a...
Source: Journal of Clinical Neuroscience - October 9, 2018 Category: Neuroscience Source Type: research

Impact of venous thromboembolism during admission for meningioma surgery on hospital charges and postoperative complications
Publication date: Available online 9 October 2018Source: Journal of Clinical NeuroscienceAuthor(s): Eleonora F. Spinazzi, Darshan Shastri, Milap Raikundalia, Nicole A. Silva, Jean Anderson Eloy, James K. LiuAbstractSurgical resection of meningiomas has been associated with high rates of venous thromboembolic events (VTE) as compared with all other intracranial tumors. There is a paucity of data regarding the clinical complications and comorbidities associated with this cohort yet the underlying pathophysiological mechanism for this tumor-specific finding remains unclear. Our goal was to determine the various impacts of VTE...
Source: Journal of Clinical Neuroscience - October 9, 2018 Category: Neuroscience Source Type: research

Acute reversal of dabigatran with Idarucizumab for intravenous thrombolysis as acute stroke treatment
We describe the case of a 73 year old male with AIS and active dabigatran use. Idarucizumab was administered per an approved medical center protocol and the patient was subsequently treated with IV rt-PA. The patient had a severe stroke with no other contraindications to IV rt-PA other than dabigatran use. The patient was administered Idarucizumab and IV rt-PA was given. Within 24 h of treatment, the patient had minimal stroke deficits. Imaging revealed a right middle cerebral artery patchy infarct. The patient was restarted on dabigatran therapy for his atrial fibrillation and was discharged to a skilled nursing facil...
Source: Journal of Clinical Neuroscience - October 9, 2018 Category: Neuroscience Source Type: research

EEG and autonomic responses to nociceptive stimulation in disorders of consciousness
Publication date: Available online 9 October 2018Source: Journal of Clinical NeuroscienceAuthor(s): Irene Venturella, Davide Crivelli, Marina Fossati, Francesca Fiorillo, Michela BalconiAbstractSince behavioral responses to external stimuli of patients presenting disorders of consciousness (DoC) are often difficult to qualify, covert physiological correlates of responsivity are deemed as potentially valuable tools to help assessment procedures. While noxious stimuli seem good candidates to explore DoC patients’ responsivity, autonomic and electrophysiological correlates of pain detection in DoC patients are still deb...
Source: Journal of Clinical Neuroscience - October 9, 2018 Category: Neuroscience Source Type: research

Cerebrospinal fluid neurofilament light in suspected sporadic Creutzfeldt-Jakob disease
Publication date: Available online 9 October 2018Source: Journal of Clinical NeuroscienceAuthor(s): Eirini Kanata, Ewa Golanska, Anna Villar-Piqué, Aikaterini Karsanidou, Dimitra Dafou, Konstantinos Xanthopoulos, Matthias Schmitz, Isidro Ferrer, André Karch, Beata Sikorska, Pawel P. Liberski, Theodoros Sklaviadis, Inga Zerr, Franc LlorensAbstractSporadic Creutzfeldt-Jakob disease (sCJD) is the most common form of human prion disease. It is invariably fatal and displays a short clinical disease stage. The key event in sCJD is the propagation of a beta-sheet rich conformer of the physiological PrPC protein, kno...
Source: Journal of Clinical Neuroscience - October 9, 2018 Category: Neuroscience Source Type: research

Dynamic changes in the reflex exam of patients with sub-axial cervical stenosis
Publication date: Available online 9 October 2018Source: Journal of Clinical NeuroscienceAuthor(s): Alexander Tuchman, Lee A. Tan, Jamal N. Shillingford, Xudong J. Li, K. Daniel RiewAbstractThough dynamic changes in the physical exam of patients being evaluated for cervical spine pathology have been reported, there is limited information on the prevalence and clinical features associated with reflex changes in a population undergoing surgical evaluation for cervical spine pathology. Fifty-one patients with at least grade 1 cervical stenosis on MRI underwent initial surgical evaluation for cervical spine pathology. All pati...
Source: Journal of Clinical Neuroscience - October 9, 2018 Category: Neuroscience Source Type: research

FokI as a genetic factor of intervertebral disc degeneration: A PRISMA-compliant systematic review of overlapping meta-analyses
Publication date: Available online 9 October 2018Source: Journal of Clinical NeuroscienceAuthor(s): Przemysław A. Pekala, Brandon Michael Henry, Dominik Taterra, Monika Piwowar, Jens Vikse, R. Shane Tubbs, Krzysztof A. TomaszewskiAbstractThe association of FokI (rs2228570), a polymorphism of the vitamin D receptor gene, with intervertebral disc degeneration (IDD) has been investigated in a multitude of studies. However, conflicting results of these studies led to emergence of several meta-analyses over the past few years. Despite the increased statistical power, these meta-analyses have failed to provide uniform and concl...
Source: Journal of Clinical Neuroscience - October 9, 2018 Category: Neuroscience Source Type: research

Delayed tension pneumocephalus following decompressive craniectomy
We describe a case that occurred in a delayed fashion following a decompressive craniectomy for a severe traumatic brain injury. It was initially treated by urgent aspiration at a peripheral hospital under neurosurgical guidance. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - October 6, 2018 Category: Neuroscience Source Type: research

Transcranial direct current stimulation: A glimmer of hope for multiple sclerosis fatigue?
Publication date: September 2018Source: Journal of Clinical Neuroscience, Volume 55Author(s): Samar S. Ayache, Moussa A. ChalahAbstractMultiple sclerosis (MS) is a neurological disease of the central nervous system characterized by inflammation, demyelination and neurodegeneration. Throughout the disease process, patients may complain of a panel of sensory, motor, cognitive and behavioral symptoms. Fatigue is a debilitating manifestation of central nervous system diseases with physical, cognitive and psychosocial dimensions. In MS, fatigue could be very frequent concerning up to 90% of patients and may have a drastic impac...
Source: Journal of Clinical Neuroscience - October 4, 2018 Category: Neuroscience Source Type: research

Quantitative analysis of the safety and efficacy of microvascular decompression for patients with trigeminal neuralgia above and below 65 years of age
Publication date: September 2018Source: Journal of Clinical Neuroscience, Volume 55Author(s): Jonathan Wallach, Allen L. Ho, Lily H. Kim, Aadel A Chaudhuri, Navjot Chaudhary, Francisco Vaz-Guimaraes, Steven D. ChangAbstractFor medically-refractory trigeminal neuralgia (TN), microvascular decompression (MVD) is the first-line treatment, and has demonstrated the greatest efficacy and durability. However, due to potential surgical complications, a bias may exist against performing MVD in elderly patients. We sought to determine through a quantitative analysis whether MVD in the elderly is a safe and effective procedure for TN...
Source: Journal of Clinical Neuroscience - October 4, 2018 Category: Neuroscience Source Type: research

National care among patients with WHO grade I intracranial meningioma
Publication date: September 2018Source: Journal of Clinical Neuroscience, Volume 55Author(s): Sunil W. Dutta, Jennifer L. Peterson, Laura A. Vallow, Anita Mahajan, Steven S. Rosenfeld, Alfredo Quiñones-Hinojosa, Daniel M. TrifilettiAbstractPurposeTo analyze the national treatment trends of patients diagnosed with benign intracranial meningioma.Methods and materialsData was obtained from the National Cancer Database (NCDB) for patients with WHO grade I meningioma tumors between 2004 and 2014 (190,527 patients), diagnosed by either surgical specimen or diagnostic imaging. Univariable and multivariable analyses (binary...
Source: Journal of Clinical Neuroscience - October 4, 2018 Category: Neuroscience Source Type: research

Memory loss and memory reorganization patterns in temporal lobe epilepsy patients undergoing anterior temporal lobe resection, as demonstrated by pre-versus post-operative functional MRI
This study was aimed to longitudinally assess memory function and whole-brain memory circuit reorganization in patients with temporal lobe epilepsy (TLE) by comparing activation potentials before versus after anterior temporal lobe (ATL) resection. Nineteen patients with medically-intractable TLE (10 left TLE, 9 right TLE) and 15 healthy controls were enrolled. Group analyses were conducted pre- and post-ATL of a novelty complex scene-encoding paradigm comparing areas of blood oxygen-level-dependent (BOLD) signal activations on functional magnetic resonance imaging (fMRI). None of the pre-operative patient characteristics ...
Source: Journal of Clinical Neuroscience - October 4, 2018 Category: Neuroscience Source Type: research

Comparison of magnetic resonance spectroscopy (MRS) with arterial spin labeling (ASL) in the differentiation between mitochondrial encephalomyopathy, lactic Acidosis, plus stroke-like episodes (MELAS) and acute ischemic stroke (AIS)
Publication date: September 2018Source: Journal of Clinical Neuroscience, Volume 55Author(s): Xiaodi Li, Yuzhou Wang, Zhanhang Wang, Jianjun Lu, Yan Xu, Jinlong Ye, Zuying Kuang, Bo Li, Mengqiu Pan, Wenming Chen, Shuisheng Lu, Ziyang Zhou, Lina Cheng, Honghao WangAbstractTo compare the utility and limitation of magnetic resonance spectroscopy (MRS) and arterial spin labeling (ASL) in the differentiation between mitochondrial encephalomyopathy, lactic acidosis, plus stroke-like episodes (MELAS) and acute ischemic stroke (AIS), a retrospective review of 17 MELAS and 26 AIS patients were performed. In all patients both MRS an...
Source: Journal of Clinical Neuroscience - October 4, 2018 Category: Neuroscience Source Type: research

Reduction of ipsilateral thalamic volume in temporal lobe epilepsy with hippocampal sclerosis
Publication date: September 2018Source: Journal of Clinical Neuroscience, Volume 55Author(s): Kang Min Park, Tae Hyung Kim, Chi Woong Mun, Kyong Jin Shin, Sam Yeol Ha, JinSe Park, Byung In Lee, Ho-Joon Lee, Sung Eun KimAbstractThe thalamus plays an important role in the modulation of both focal and generalized seizures, but the mechanisms related to seizures may be different among epilepsy syndromes. The aim of this study is to investigate the thalamic atrophy in different epilepsy syndromes. We enrolled a total of 72 patients with epilepsy (22 patients with temporal lobe epilepsy with hippocampal sclerosis, 21 patients wi...
Source: Journal of Clinical Neuroscience - October 4, 2018 Category: Neuroscience Source Type: research

Molecular physiology of contrast enhancement in glioblastomas: An analysis of The Cancer Imaging Archive (TCIA)
Publication date: September 2018Source: Journal of Clinical Neuroscience, Volume 55Author(s): Jeffrey M. Treiber, Tyler C. Steed, Michael G. Brandel, Kunal S. Patel, Anders M. Dale, Bob S. Carter, Clark C. ChenAbstractThe physiologic processes underlying MRI contrast enhancement in glioblastoma patients remain poorly understood. MRIs of 148 glioblastoma subjects from The Cancer Imaging Archive were segmented using Iterative Probabilistic Voxel Labeling (IPVL). Three aspects of contrast enhancement (CE) were parametrized: the mean intensity of all CE voxels (CEi), the intensity heterogeneity in CE (CEh), and volumetric rati...
Source: Journal of Clinical Neuroscience - October 4, 2018 Category: Neuroscience Source Type: research

Iatrogenic subcutaneous metastasis from WHO Grade I intracranial meningioma
We present the case of a young woman with the unusual phenomenon of iatrogenic subcutaneous seeding from an intracranial meningioma. We discuss the risk factors, possible mechanisms and management of this. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - October 4, 2018 Category: Neuroscience Source Type: research

Diagnostic utility of restriction spectrum imaging (RSI) in glioblastoma patients after concurrent radiation-temozolomide treatment: A pilot study
Publication date: Available online 22 September 2018Source: Journal of Clinical NeuroscienceAuthor(s): Usman A. Khan, Robert C. Rennert, Nathan S. White, Hauke Bartsch, Nikdokht Farid, Anders M. Dale, Clark C. ChenAbstractDiscriminating between tumor recurrence and treatment effects in glioblastoma patients undergoing radiation-temozolomide (RT/TMZ) therapy remains a major clinical challenge. Here, we report a pilot study to determine the utility of restriction spectrum imaging (RSI), an advanced diffusion-weighted MRI (DWI) technique that affords meso-scale resolution of cell density, in this assessment. A retrospective r...
Source: Journal of Clinical Neuroscience - October 4, 2018 Category: Neuroscience Source Type: research

Management and outcomes of pregnant patients with central nervous system hemangioblastoma
Publication date: Available online 24 September 2018Source: Journal of Clinical NeuroscienceAuthor(s): Xiu-jian Ma, Guo-bin Zhang, Teng-xian Guo, Cheng-bei Li, Yu-jia Chen, Li-wei Zhang, Zhen Wu, Jun-ting ZhangAbstractThe study aims to assess the management and maternal and fetal outcomes of pregnancies complicated by central nervous system (CNS) hemangioblastoma. Twenty-four female patients with CNS hemangioblastoma, who were pregnant in a tumor-burden status, were identified. Their medical charts, treatments, and follow-up materials were carefully reviewed. Of the included 24 CNS patients with hemangioblastoma (14 intrac...
Source: Journal of Clinical Neuroscience - October 4, 2018 Category: Neuroscience Source Type: research

Pathogenesis of dorsal internal carotid artery wall aneurysms based on histopathologic examination and microscopic configuration
In this report, BBAs were histopathologically examined in two patients who presented with SAH due to rupture of a BBA that was treated with surgical trapping and bypass surgery. BBA specimens including the adjacent internal carotid artery (ICA) walls were obtained intraoperatively.We suggest the pathogenesis of BBAs based on histopathologic examination and microscopic configuration. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - October 4, 2018 Category: Neuroscience Source Type: research