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The utilization of MGMT promoter methylation testing in United States hospitals for glioblastoma and its impact on prognosis
Publication date: Available online 23 February 2018 Source:Journal of Clinical Neuroscience Author(s): Anna Lee, Irini Youssef, Virginia W. Osborn, Joseph Safdieh, Daniel J. Becker, David Schreiber Multiple studies have identified O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation status to be an important prognostic factor in glioblastoma (GBM). We used the National Cancer Data Base (NCDB) to analyze completeness of coding for MGMT as well as to compare outcomes of GBM patients treated with adjuvant chemoradiation based on MGMT promoter methylation status (positive, negative, unknown). Patients diagnosed ...
Source: Journal of Clinical Neuroscience - February 23, 2018 Category: Neuroscience Source Type: research

Association of insurance status and spinal fusion usage in the United States during two decades
Conclusions Total discharges with spinal fusion increased significantly across all payer groups between 1997 and 2014, but not equally. Further inquiry is indicated to determine the etiology of spinal fusion usage discrepancies between payer groups. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - February 22, 2018 Category: Neuroscience Source Type: research

Lumbar disc herniation surgery with microdiscectomy plus interspinous stabilization: Good clinical results, but failure to lower the incidence of re-operation
Conclusion Our short-term experience indicates that microdiscectomy plus interspinous device is safe and it shows good clinical results, although the clinical improvement seems to be due to microdiscectomy, without the implant adding any extra benefit. The addition of IDSS did not protect against re-operation, and it increased the surgical expenses. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - February 21, 2018 Category: Neuroscience Source Type: research

The reliability of LERI ’s sign in L4 and L3 radiculalgia
Publication date: Available online 21 February 2018 Source:Journal of Clinical Neuroscience Author(s): Keyvan Mostofi, Babak Gharaie Moghaddam, Reza Karimi Khouzan, Mathieu Daryabin Although not as frequent as sciatica, cruralgia remains one of the most frequent reasons why people consult a neurosurgeon. It should be kept in mind, however, that every anterior leg pain is not cruralgia and thus several diagnoses must be discarded, such as of musculoskeletal diseases of hip, pelvis and femur. In the last years of the 19th century, André Léri, a French neurologist, described Leri’s sign as it is used wide...
Source: Journal of Clinical Neuroscience - February 21, 2018 Category: Neuroscience Source Type: research

The difficulty of predicting clinical outcome after intended submaximal resection of large vestibular Schwannomas
Conclusion Intended submaximal resection provides satisfactory neurological outcome for patients with large VS. Risk factors for postoperative neurological deterioration remain unclear. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - February 21, 2018 Category: Neuroscience Source Type: research

Rapid progressive visual decline and visual field defects in two patients with the Heidenhain variant of Creutzfeld-Jakob disease
Conclusions Loss of visual acuity and a decline in visual fields without corresponding MRI findings and marked changes in behaviour should lead to a diagnosis of HvCJD. Corresponding diagnostic tests should be performed for confirmation. The prognosis for survival is poor and should be immediately communicated to affected patients and their relatives. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - February 21, 2018 Category: Neuroscience Source Type: research

Evaluation and management of small dural tears in primary lumbar spinal decompression and discectomy surgery
Publication date: Available online 21 February 2018 Source:Journal of Clinical Neuroscience Author(s): Marcelo Galarza, Roberto Gazzeri, Raúl Alfaro, Pedro de la Rosa, Cinta Arraez, Claudio Piqueras Incidental dural tear is one of the most common intraoperative complications in lumbar spine surgery. Yet, its technical management for the prevention of CSF leak is controversial. The technique of managing dural tears depends on the location of the dural tears as well on the length and anatomical characteristics of the dural tear. We propose an anatomical classification for small (less than one cm) dural tears and repo...
Source: Journal of Clinical Neuroscience - February 21, 2018 Category: Neuroscience Source Type: research

Spinal primary central nervous system lymphoma: Case report and literature review
Publication date: Available online 21 February 2018 Source:Journal of Clinical Neuroscience Author(s): Li Feng, Dingbang Chen, Hongyan Zhou, Cunzhou Shen, Haiyan Wang, Xunsha Sun, Xiulin Liang, Ling Chen Primary central nervous system lymphoma (PCNSL) is a very rare tumor of increasing incidence. It is often misdiagnosed due to the unspecific presentation or unavailable biopsy, and results in poor prognosis. PCNSL involved the spinal cord is extremely sparse. Here we report a gentleman presented with one-year history of progressive tremor in the left limbs and slight dysarthria as well as three-month history of paraparesi...
Source: Journal of Clinical Neuroscience - February 21, 2018 Category: Neuroscience Source Type: research

Novel SGCE mutation in a patient with myoclonus-dystonia syndrome – Diagnostic delay of more than 40 years
We present a case of myoclonus-dystonia syndrome illustrated by three videos in which we found a novel SGCE mutation. As the patient described here was suffering from predominant psychiatric comorbidities it took more than 40 years from the first manifestation of the disease until the diagnosis. Having detected the genetically proven cause for his motor and non-motor symptoms was an enormous relief to our patient. We want to share this instructive case in order to prompt neurologists and psychiatrists to look closely at both movement disorders and neuropsychiatric signs in order to diagnose and treat patients to the late...
Source: Journal of Clinical Neuroscience - February 21, 2018 Category: Neuroscience Source Type: research

A purely functional Imaging based approach for transcortical resection of lesion involving the dominant atrium: Towards safer, imaging-guided, tailored cortico-leucotomies
Conclusions A purely functional surgical approach to the DA provided promising preliminary results. A direct DTI-fMRI visualization of the eloquent structures proximal to DA allows surgeon to conceive an ultra-precise and “tailored” cortico-leucotomy for an optimal exposure of the lesion. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - February 21, 2018 Category: Neuroscience Source Type: research

In-hospital medical complications after non-operative and operative treatment of thoracolumbar fractures in patients over 75  years of age
Publication date: Available online 21 February 2018 Source:Journal of Clinical Neuroscience Author(s): Taylor E. Purvis, Rafael De la Garza Ramos, Eric W. Sankey, Isaac O. Karikari, C. Rory Goodwin, Daniel M. Sciubba Management of spine fractures among the elderly is complicated by preexisting comorbidities and increased risk of osseous nonunion. Whether operative treatment is superior for the management of thoracolumbar fractures in the aged is unknown. The purpose of this study was to investigate the rates of in-hospital medical complications after non-operative and operative treatment of thoracolumbar fractures in elde...
Source: Journal of Clinical Neuroscience - February 21, 2018 Category: Neuroscience Source Type: research

Pharmacological interventions for treating sialorrhea associated with neurological disorders: A mixed treatment network meta-analysis of randomized controlled trials
Publication date: Available online 21 February 2018 Source:Journal of Clinical Neuroscience Author(s): Kannan Sridharan, Gowri Sivaramakrishnan Sialorrhea is a common distress associated with certain neurological disorders. The aim of this study is to compare the pharmacological agents used for treating sialorrhea by network meta-analysis. Electronic databases were searched for randomized clinical trials comparing active drugs with either placebo or other active drugs. Total drooling scores was the primary outcome measure. Inverse variance heterogeneity model was used for both direct and mixed treatment comparison analysi...
Source: Journal of Clinical Neuroscience - February 21, 2018 Category: Neuroscience Source Type: research

Idiopathic thoracic spinal cord herniation
Publication date: Available online 19 February 2018 Source:Journal of Clinical Neuroscience Author(s): Michael G.Z. Ghali, Visish M. Srinivasan, Vikas Y. Rao, Ibrahim Omeis Idiopathic spinal cord herniation represents an uncommon and unique diagnostic entity, most commonly affecting middle-aged individuals, with a nearly twofold female predilection. It most characteristically affects the mid-thoracic spine, with the herniation occurring ventrally or ventrolaterally. Clinical presentation is typically a slowly-progressive myelopathy, with Brown-Séquard syndrome occurring more frequently than spastic paraparesis. Dia...
Source: Journal of Clinical Neuroscience - February 20, 2018 Category: Neuroscience Source Type: research

3,4-Diaminopyridine for the treatment of myasthenia gravis with electrophysiological patterns of Lambert-Eaton myasthenic syndrome
In conclusion, this study results provide evidence that 34DAP could be effective in sero-positive MG patients with pre-synaptic dysfunction. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - February 19, 2018 Category: Neuroscience Source Type: research

Spontaneous, atraumatic posterior fossa subdural hematoma
Publication date: Available online 17 February 2018 Source:Journal of Clinical Neuroscience Author(s): Andrew Kobets, David Altschul, Jonathan Nakhla, Kevin Kwan, Julia Schneider, David S. Gordon (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - February 18, 2018 Category: Neuroscience Source Type: research

Spontaneous, atraumatic posterior fossa subdural hematoma: Answer
Publication date: Available online 17 February 2018 Source:Journal of Clinical Neuroscience Author(s): Andrew Kobets, David Altschul, Jonathan Nakhla, Kevin Kwan, Julia Schneider, David S. Gordon (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - February 18, 2018 Category: Neuroscience Source Type: research

Risk factors for platelet transfusion in glioblastoma surgery
The objectives of this study are to identify risk factors for and to evaluate clinical outcomes of platelet transfusion in glioblastoma surgery. The medical records of adult patients who underwent craniotomy for glioblastoma resection at a single academic medical center were retrospectively reviewed. We stratified patients into 2 groups: those who were transfused at least 1 unit of platelets intraoperatively or postoperatively (no more than 7 days after surgery), and those who were not transfused with platelets. Through the use of a 1:3 matched cohort analysis, we compared complications, length of stay, discharge disposi...
Source: Journal of Clinical Neuroscience - February 14, 2018 Category: Neuroscience Source Type: research

Reversal of antiplatelet therapy in traumatic intracranial hemorrhage: Does timing matter?
Publication date: Available online 13 February 2018 Source:Journal of Clinical Neuroscience Author(s): Urmil Pandya, Alexander Malik, Michael Messina, Abdul-Rahman Albeiruti, Chance Spalding Reversal of antiplatelet therapy with platelet transfusion in traumatic intracranial hemorrhage remains controversial. Several studies have examined this topic but few have investigated whether the timing of transfusion affects outcomes. Patients admitted to a level 1 trauma center from 1/1/14 to 3/31/16 with traumatic intracranial hemorrhage taking pre-injury antiplatelet therapy were retrospectively analyzed. Patients on concurrent ...
Source: Journal of Clinical Neuroscience - February 14, 2018 Category: Neuroscience Source Type: research

Muscle strength and psychiatric symptoms influence health-related quality of life in patients with myasthenia gravis
Conclusion: Anxiety and depressive symptoms, besides motor symptoms, influence HRQOL in MG. Mental health must be a clinical focus in addition to the treatment of somatic symptoms during the course of MG. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - February 14, 2018 Category: Neuroscience Source Type: research

Ossified extradural en-plaque meningioma of the cervical spine
Publication date: Available online 14 February 2018 Source:Journal of Clinical Neuroscience Author(s): Koichiro Sakamoto, Satoshi Tsutsumi, Senshu Nonaka, Takamoto Suzuki, Hisato Ishii, Masanori Ito, Yukimasa Yasumoto A 57-year-old woman sustained gradually progressive sensorimotor disturbance in the left upper extremity for one year. Neurological examination found a diminished sensation below the left C7 dermatome and reduced strength in the left interosseous muscles. Computed tomography of the cervical spine revealed a high density mass at C7, in the left dorsal part of the spinal canal. Magnetic resonance imaging found...
Source: Journal of Clinical Neuroscience - February 14, 2018 Category: Neuroscience Source Type: research

Reduced frontal activity during a verbal fluency test in fibromyalgia: A near-infrared spectroscopy study
In conclusion, our study demonstrated a reduced frontal cortical activity during VFT in FM patients, and that NIRS could be a potential tool for evaluating brain function in FM patients in clinical settings. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - February 14, 2018 Category: Neuroscience Source Type: research

Microelectrode accuracy in deep brain stimulation surgery
In this study, we report the accuracy of microelectrode tip placement in comparison to preoperatively planned radiographic target. Patients who underwent DBS with MER from 2014 to 2016 were included in the study. At the authors’ institution, intra-operative CT (iCT) is routinely performed after the first microelectrode track to confirm tip accuracy. Retrospective analysis of microelectrode track error was calculated between the planned trajectory and the microelectrode tip. The radial error was calculated on the same axial plane using the Euclidian distance formula, and multivariate analysis was performed to ascertai...
Source: Journal of Clinical Neuroscience - February 12, 2018 Category: Neuroscience Source Type: research

Symptom-associated change of motor-related neuromagnetic fields in a patient with multiple sclerosis: A case report
The objective of this study was to investigate functional abnormalities of the brain in a patient with multiple sclerosis (MS) by using magnetoencephalography (MEG) and a finger-tapping task. A 46-year-old woman that presented with motor weakness of left hand and was diagnosed with MS. Conventional magnetic resonance imaging demonstrated a white matter lesion with hyperintensity on T2-weighted images in the right motor area. MEG recordings were performed during the period of motor weakness and after clinical improvement. Neuromagnetic brain activation was elicited by a simple, visually cued finger movement. The Equivalent ...
Source: Journal of Clinical Neuroscience - February 11, 2018 Category: Neuroscience Source Type: research

Three-dimensional intracranial middle cerebral artery aneurysm models for aneurysm surgery and training
This study included eight MCA aneurysm cases. The aneurysm together with the adjacent arteries and skull base were printed based on raw computed tomography angiography (CTA) data using a 3D printer with acrylonitrile-butadiene-styrene as the model material. The aneurysm models were used for surgical planning, and craniotomy and clipping practice by neurosurgical residents. Feedback was obtained using a survey. 3D aneurysm models were created for all seven MCA aneurysm patients. There was good agreement in the model aneurysm diameter, width, and neck and the CTA data, with no significant difference (p > 0.05) amo...
Source: Journal of Clinical Neuroscience - February 11, 2018 Category: Neuroscience Source Type: research

Posterior spinal cord shift does not affect surgical outcomes after muscle-preserving selective laminectomy
Publication date: Available online 10 February 2018 Source:Journal of Clinical Neuroscience Author(s): Satoshi Nori, Tateru Shiraishi, Ryoma Aoyama, Ken Ninomiya, Junichi Yamane, Kazuya Kitamura, Seiji Ueda Postoperative posterior spinal cord shift (PSS) has been considered a required radiographic endpoint of posterior decompression procedures. To achieve PSS, laminoplasty for cervical compressive myelopathy (CCM) has been consecutively performed on four or more laminae (C2–C7, C3–C7, or C3–C6). However, the clinical significance of PSS remains controversial. By selecting the surgically treated laminae, ...
Source: Journal of Clinical Neuroscience - February 11, 2018 Category: Neuroscience Source Type: research

Dermoid cysts of the conus medullaris: Clinical review, case series and management strategies
Conclusion Dermoid cysts of the conus medullaris are challenging to treat. Surgical control and restraint are key, especially when patients are young and could potentially fully recover and remain in remission for a period of years. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - February 11, 2018 Category: Neuroscience Source Type: research

Images in Neuroscience: Calvarial hyperostosis associated with multiple intracranial tumours
Publication date: Available online 7 February 2018 Source:Journal of Clinical Neuroscience Author(s): Mario Ganau, Marco Paris, Chris Uff (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - February 8, 2018 Category: Neuroscience Source Type: research

Impact of post craniectomy cranioplasty on cerebral perfusion and clinical outcome
Publication date: March 2018 Source:Journal of Clinical Neuroscience, Volume 49 Author(s): Varidh Katiyar, Ravi Sharma, Hitesh Kumar Gurjar (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - February 4, 2018 Category: Neuroscience Source Type: research

The hybrid assisted limb (HAL) for Care Support, a motion assisting robot providing exoskeletal lumbar support, can potentially reduce lumbar load in repetitive snow-shoveling movements
In conclusion, the HAL for Care Support can reduce lumbar load in repetitive snow-shoveling movements. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - February 4, 2018 Category: Neuroscience Source Type: research

A morphometric and analytical cadaver dissection study of a tumor-simulation balloon model
Publication date: March 2018 Source:Journal of Clinical Neuroscience, Volume 49 Author(s): Baran Bozkurt, Evgenii Belykh, Kaan Yağmurlu, Abhishek Agrawal, Steve W. Chang, Michael S. Staren, Robert F. Spetzler, Joseph M. Zabramski, Mark C. Preul We quantified the effects on anatomical cadaver dissection of a balloon-inflation tumor model positioned in the parasellar region and approached through an orbitozygomatic (OZ) craniotomy. A modified supraorbital OZ was performed bilaterally on 5 silicon-injected cadaver heads. Ten predetermined anatomical points assigned using a frameless stereotactic device were used to measure ...
Source: Journal of Clinical Neuroscience - February 4, 2018 Category: Neuroscience Source Type: research

Clinical pathologic case report: A 70-year-old man with inflammatory cerebral amyloid angiopathy causing headache, cognitive impairment, and aphasia
Publication date: March 2018 Source:Journal of Clinical Neuroscience, Volume 49 Author(s): Grace F. Crotty, Kathleen McKee, Altaf Saadi, Andrew C. Young, Isaac H. Solomon, Jennifer L. Lyons A 70-year-old man presented with two months of worsening cognitive impairment, hallucinations, and difficulty speaking, with superimposed headaches. Cerebrospinal fluid analysis was notable for lymphocytic pleocytosis and elevated protein. Imaging studies revealed multiple acute and subacute infarcts with cortical microhemorrhages. The patient underwent a stereotactic brain biopsy. In this article, we discuss the patient’s differ...
Source: Journal of Clinical Neuroscience - February 4, 2018 Category: Neuroscience Source Type: research

Embolization of cranial dural arteriovenous fistulas in the liquid embolic era: A Sydney experience
Publication date: March 2018 Source:Journal of Clinical Neuroscience, Volume 49 Author(s): Catherine S. Johnson, Albert Chiu, Andrew Cheung, Jason Wenderoth Endovascular management of dural arteriovenous fistulas has become a mainstay of treatment. In particular, modern techniques have allowed greater fistula penetration and likelihood of complete obliteration. However, the efficacy of newer agents has not been quantified outside of predominantly small case reports and case series. Furthermore, the Australian experience with fistula embolization has yet to be reported in the literature. To this aim, we performed a retrosp...
Source: Journal of Clinical Neuroscience - February 4, 2018 Category: Neuroscience Source Type: research

High-grade thalamic gliomas: Microsurgical treatment and prognosis analysis
Publication date: March 2018 Source:Journal of Clinical Neuroscience, Volume 49 Author(s): Biwu Wu, Chao Tang, Yang Wang, Zhiqi Li, Shukun Hu, Wei Hua, Wengang Li, Shan Huang, Junfeng Ma, Yi Zhang This retrospective study is aimed to investigate the efficacy of microsurgical treatment for high-grade thalamic gliomas, and to analyze the relevant prognosis. From May 2011 to Aug 2015, 49 patients with thalamic gliomas underwent microsurgical resection, and received chemotherapy and radiotherapy postoperatively. The postoperative symptoms and complications were documented, and the overall survival (OS) and the progression-fre...
Source: Journal of Clinical Neuroscience - February 4, 2018 Category: Neuroscience Source Type: research

Postoperative radiosurgery for the treatment of metastatic brain tumor: Evaluation of local failure and leptomeningeal disease
We present an institutional experience of postoperative radiosurgery for the treatment of brain metastases. A retrospective review of a prospectively maintained institutional radiosurgery database was performed for the years 2005–2015 identifying all adult patients treated with postoperative radiosurgery to the tumor bed. Primary endpoints include local recurrence and postoperative LMD. Kaplan-Meier curves and Cox regression were used to evaluate time to local recurrence and postoperative LMD. Ninety-one patients received adjuvant focal radiation for a brain metastasis. Median radiographic follow-up among patients wh...
Source: Journal of Clinical Neuroscience - February 4, 2018 Category: Neuroscience Source Type: research

Which surgical procedure is effective for refractory chronic subdural hematoma? Analysis of our surgical procedures and literature review
Publication date: March 2018 Source:Journal of Clinical Neuroscience, Volume 49 Author(s): Hiroaki Matsumoto, Hiroaki Hanayama, Takashi Okada, Yasuo Sakurai, Hiroaki Minami, Atsushi Masuda, Shogo Tominaga, Katsuya Miyaji, Ikuya Yamaura, Yasuhisa Yoshida Refractory chronic subdural hematoma (CSDH) is rare but remains a difficulty for neurosurgeons, and no consensus on treatment procedures has been established. To discuss effective surgical procedures for refractory CSDH, we analyzed our surgical procedures and outcomes for refractory CSDH. We defined patients with refractory CSDH as those who presented with two or more rec...
Source: Journal of Clinical Neuroscience - February 4, 2018 Category: Neuroscience Source Type: research

Orolingual angioedema treated with Icatibant post-thrombolysis for ischaemic stroke
Publication date: March 2018 Source:Journal of Clinical Neuroscience, Volume 49 Author(s): Patrick J. Salvaris, Joshua Laing (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - February 4, 2018 Category: Neuroscience Source Type: research

Cerebrospinal fluid biomarkers of Alzheimer ’s disease are associated with carotid plaque score and hemodynamics in intra- and extra-cranial arteries on ultrasonography
Publication date: March 2018 Source:Journal of Clinical Neuroscience, Volume 49 Author(s): Minoru Kouzuki, Masaya Nagano, Tetsuya Suzuki, Yuto Katsumata, Syouta Nakamura, Ayumi Takamura, Katsuya Urakami Carotid plaque score (PS) and hemodynamic abnormalities in intra- and extra-cranial arteries are related to Alzheimer’s disease (AD) progression. As these parameters are measured conveniently and non-invasively by ultrasonography, we examined their association with cerebral spinal fluid (CSF) AD biomarkers amyloid β (Aβ) and phosphorylated tau (p-tau). Carotid PS, mean flow velocity (MFV) in multiple intra-...
Source: Journal of Clinical Neuroscience - February 4, 2018 Category: Neuroscience Source Type: research

Management of a complex intracranial arteriovenous malformation with gamma knife radiosurgery: A case report with review of literature
Publication date: March 2018 Source:Journal of Clinical Neuroscience, Volume 49 Author(s): Shyamal C. Bir, Subhas K. Konar, Devi P. Patra, Tanmoy K. Maiti, Alireza Minagar, Anil Nanda The risks and benefits of arteriovenous malformation (AVM) treatment should be considered cautiously in each patient since management strategy of it depends on various factors including age of the patient, location and volume of AVM and presence of other vascular abnormalities. Current management options of AVM include observation, endovascular embolization, radiosurgery and microsurgical resection or in combination of any two of the above p...
Source: Journal of Clinical Neuroscience - February 4, 2018 Category: Neuroscience Source Type: research

Hispanic and African American adult brain tumor patients treated at Harbor-UCLA Medical Center compared to Los Angeles County and Torrance, California
The objective of this study is to shed light on racial disparities among Hispanic and African American adult brain tumor patients treated at Harbor-UCLA Medical Center compared to the general populations of Los Angeles County (LAC) and Torrance, California (CA). A retrospective review of patients admitted to the neurosurgery service at Harbor-UCLA Medical Center during years 2006 through 2010 was performed. Government census data was queried and pertinent national statistics were retrieved. Brain tumor patients at Harbor-UCLA were compared to the general populations of LAC and Torrance. A total of 271 patients were include...
Source: Journal of Clinical Neuroscience - February 4, 2018 Category: Neuroscience Source Type: research

Atypical teratoid/rhabdoid tumor of the sellar region in adult women: Is it a sex-related disease?
Publication date: March 2018 Source:Journal of Clinical Neuroscience, Volume 49 Author(s): Akihiro Nishikawa, Toshihiro Ogiwara, Alhusain Nagm, Kenji Sano, Maki Okada, Akihiro Chiba, Masahiro Agata, Tomoki Kaneko, Hisashi Tamada, Takeshi Uehara, Kazuhiro Hongo Atypical teratoid/rhabdoid tumor (AT/RT) is a highly malignant embryonal tumor in children and a rare entity. Although adult AT/RT is extremely rare, some cases of adult-onset AT/RT in the sellar region have been described. Here, we report an adult patient with AT/RT of the sellar region in whom it was difficult to make a definitive diagnosis and the clinical course...
Source: Journal of Clinical Neuroscience - February 4, 2018 Category: Neuroscience Source Type: research

Intramedullary spinal cord metastasis from thyroid carcinoma: Case report and a systematic pooled analysis of the literature
We report a case of a 49-year-old woman with known primary papillary thyroid carcinoma, who presented with rapidly progressive clinical features of Brown-Sequard syndrome. A detailed pooled analysis of the literature was conducted to characterise the clinical and demographic features, management options, and expected survival outcomes for cases of ISCM. We secondarily performed a subgroup analysis on the incidence, clinical and management characteristics of thyroid carcinoma ISCM. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - February 4, 2018 Category: Neuroscience Source Type: research

Eteplirsen for paediatric patients with Duchenne muscular dystrophy: A pooled-analysis
Conclusions Whether or not this increase in percentage dystrophin-positive fibres and distance walked is clinically significant is unclear, and there is therefore a need for more clinical trials. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - February 4, 2018 Category: Neuroscience Source Type: research

Spinal hemangioma mimicking a dumbbell-shaped schwannoma: Case report and review of the literature
We present the case of a fifty-one year old woman who presented with myelopathy and was discovered to have a large mass causing epidural spinal cord compression, thought to be due to a peripheral nerve sheath tumor. She underwent surgery for tumor debulking. Intraoperatively, the mass was found to be mostly epidural with minimal bone involvement. Final pathology demonstrated a cavernous hemangioma. The patient did well post-operatively, with resolution of symptoms and stable size of residual tumor on eighteen month follow-up imaging. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - February 3, 2018 Category: Neuroscience Source Type: research

Outcome in chronic inflammatory demyelinating polyneuropathy from a Malaysian centre over sixteen years
In conclusion, treatment outcomes of our CIDP cohort was comparable to those of published series. Further studies with larger cohort of patients from other parts of Asia are important to determine the long-term outcome of this heterogenous disease in this region. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - February 3, 2018 Category: Neuroscience Source Type: research

Red man syndrome caused by vancomycin powder
We describe the first reported case of RMS as a result of local intra-wound application of vancomycin powder for infection prophylaxis. A 73-year-old male with a history of Parkinson’s disease underwent 2-stage deep brain stimulation implantation surgeries. Vancomycin powder was applied locally in the surgical wounds for infection prophylaxis during both of the surgeries. The patient developed a well-demarcated, geometric erythematous pruritic rash following the second surgery that was clinically diagnosed as RMS and resolved without sequelae. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - February 3, 2018 Category: Neuroscience Source Type: research

Unusual paediatric spinal myxopapillary ependymomas: Unique molecular entities or pathological variations on a theme?
Publication date: Available online 3 February 2018 Source:Journal of Clinical Neuroscience Author(s): Sasha Rogers, David T.W. Jones, Amanda Ireland, Nick G. Gottardo, Raelene Endersby Ependymomas are the commonest type of spinal glioma which represent a group of relatively benign tumours. Myxopapillary ependymoma (MPE) is a common variant found within the distal spinal cord around the conus. These two entities are clearly differentiated on the basis of their characteristic histological and molecular features. Rare variants of MPE’s are described in the literature to have the propensity to metastasise and grow in ex...
Source: Journal of Clinical Neuroscience - February 3, 2018 Category: Neuroscience Source Type: research

Advantages of an on-the-screwhead crosslink connector for atlantoaxial fixation using the Goel/Harms technique
Publication date: Available online 3 February 2018 Source:Journal of Clinical Neuroscience Author(s): Jun Mizutani, Atsushi Inada, Kenji Kato, Akira Kondo, Shingo Kainuma, Kazuhiko Fujita, Kiyoshi Yagi, Yasuteru Shimamura, Muneyoshi Fukuoka, Yuta Shibamoto, Ikuo Wada, Takanobu Otsuka The goal of fixation surgery for atlantoaxial instability is to achieve solid bony fusion. Achieving bony fusion as early as possible is beneficial for patients. Although placement of a transverse cross-link connector (XL) provides greater biomechanical strength, XLs have not been able to be placed when performing the Goel/Harms procedure. Re...
Source: Journal of Clinical Neuroscience - February 3, 2018 Category: Neuroscience Source Type: research

Monitoring of optic nerve function in Neurofibromatosis 2 children with optic nerve sheath meningiomas using multifocal visual evoked potentials
This study was undertaken to describe the use of multifocal visual evoked potentials (multifocal VEP, mfVEP) in the regular monitoring of NF2 patients with ONSM. This study involved three NF2 patients with ONSM who undertook mfVEP testing at an academic ophthalmic centre. Same day mfVEP and routine ophthalmic testing were undertaken. Topographical function of the optic nerve was assessed, utilising tools such as asymmetry deviation and accumap severity index. Results were assessed alongside MRI and visual acuity (VA). From the three patients, five eyes had ONSMs, of which two caused unilateral blindness. The remaining thre...
Source: Journal of Clinical Neuroscience - February 3, 2018 Category: Neuroscience Source Type: research

Does epiaortic ultrasound screening reduce perioperative stroke in patients undergoing coronary surgery? A topical review
Publication date: Available online 3 February 2018 Source:Journal of Clinical Neuroscience Author(s): Asad Ikram, Hafsa Mohiuddin, Aisha Zia, Hafiz Umair Siddiqui, Hoda Javadikasgari, Marijan Koprivanac, Sajjad Raza, Atif Zafar Although the occurrence of stroke in patients undergoing coronary artery bypass grafting (CABG) is decreasing, it remains an important concern. Therefore, it is important to identify and adopt strategies that can decrease the incidence of stroke in these patients. One of the strategies that have demonstrated the potential to decrease the rate of post-CABG stroke is an assessment of aorta for athero...
Source: Journal of Clinical Neuroscience - February 3, 2018 Category: Neuroscience Source Type: research

Clinical presentation and treatment paradigms in patients with hereditary hemorrhagic telangiectasia and spinal vascular malformations
We present our experience with the presentation and management of spinal vascular malformations in patients with HHT. Of the more than 800 patients with the diagnosis of HHT screened at our institution from 1995 through 2017, four patients with spinal vascular malformations (age range 1 month–77 years; 2 male, 2 female) were identified, three of whom came to clinical attention after significant neurological deterioration from previously unknown malformations. A review of the literature including our patients demonstrated 29 total spinal arteriovenous fistulas (AVFs) in 28 HHT patients (69% male). The lesions were...
Source: Journal of Clinical Neuroscience - February 3, 2018 Category: Neuroscience Source Type: research