Occipital neuralgia: A neurosurgical perspective
The objective of this paper is to isolate the etiology involved, and treat this condition promptly. After all nonoperative efforts are exhausted, surgical transection of the nerve is the treatment of choice in these cases. An isolated C2 neurectomy or ganglionectomy is performed for an optimal pain relief. C1-2 instrumented fusion can be considered if, extensive facet arthropathy with instability is identified. Authors review the spectrum of treatment options for this debilitating condition, and discuss the case example of a patient who required conversion to a C1-C2 instrumented fusion following C2 ganglionectomy due to a...
Source: Journal of Clinical Neuroscience - October 10, 2019 Category: Neuroscience Source Type: research

Effects of anticoagulant and antiplatelet agents in severe traumatic brain injury in an asian population – A matched case-control study
Publication date: Available online 9 October 2019Source: Journal of Clinical NeuroscienceAuthor(s): Liming Qiu, Julian Xinguang Han, Angela An Qi See, Nicolas Kon Kam KingAbstractThe use of anticoagulation and antiplatelet agents (ACAP) has steadily increased over recent years. However, the effects of ACAP on traumatic brain injuries (TBI) are not well investigated. The aim of this study was to investigate the effects of pre-injury ACAP use on clinical outcome and mortality in severe TBI. A retrospective case-control study was performed for all patients who presented with severe TBI (GCS 
Source: Journal of Clinical Neuroscience - October 10, 2019 Category: Neuroscience Source Type: research

Whole genome and biomarker analysis of patients with recurrent glioblastoma on bevacizumab: A subset analysis of the CABARET trial
Publication date: Available online 30 September 2019Source: Journal of Clinical NeuroscienceAuthor(s): Lauren R. Olafson, Anna H. Siddell, Kathryn M. Field, Madeleine Byrnes, Robert W. Rapkins, Benedict Ng, Sheri Nixdorf, Elizabeth H. Barnes, Terrance G. Johns, Sonia Yip, John Simes, Anna K. Nowak, Mark A. Rosenthal, Kerrie L. McDonaldAbstractThe CABARET trial (ACTRN12610000915055) reported no difference in overall survival (OS) between patients with recurrent glioblastoma (GBM) randomized to either bevacizumab monotherapy or bevacizumab plus carboplatin. However, a subset of patients showed durable responses and prolonged...
Source: Journal of Clinical Neuroscience - October 2, 2019 Category: Neuroscience Source Type: research

Noninvasive and quantitative evaluation of movement disorder disability using an infrared depth sensor
This study aimed to investigate the usefulness of an infrared depth sensor device to quantitatively evaluate gait disturbances in patients with movement disorders. 25 ataxic, 25 Parkinson’s disease, and 25 control subjects were enrolled and evaluated their walk. Stride length, feet interval, gait rhythm, and a ratio of the actual walking route length to the linear distance between the start and goal points (A/L ratio) were assessed and compared. Outcome correlations with clinical scales were also analyzed. The average stride length was shorter in ataxic subjects or Parkinson’s disease subjects than in control s...
Source: Journal of Clinical Neuroscience - September 27, 2019 Category: Neuroscience Source Type: research

Ruptured intracranial aneurysm in a neonate
Publication date: Available online 24 September 2019Source: Journal of Clinical NeuroscienceAuthor(s): Alejandro Santillan, Kenroy Brown, Athos Patsalides (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - September 25, 2019 Category: Neuroscience Source Type: research

Elevated inflammation and decreased platelet activity is associated with poor outcomes after traumatic brain injury
Publication date: Available online 23 September 2019Source: Journal of Clinical NeuroscienceAuthor(s): Cole T. Lewis, Jude P.J. Savarraj, Mary F. McGuire, Georgene W. Hergenroeder, H. Alex Choi, Ryan S. KitagawaAbstractThe inflammatory processes following traumatic brain injury (TBI) have not been fully characterized. We hypothesize that differences in systemic cytokine/chemokine (CC) levels are associated with TBI clinical outcomes. To test this hypothesis, we examined systemic levels of CCs and their relationship with patient outcomes. Plasma from acute TBI subjects was collected at 24–48 h, and the CC levels wer...
Source: Journal of Clinical Neuroscience - September 25, 2019 Category: Neuroscience Source Type: research

Incidence of seroconversion and sero-reversion in patients with multiple sclerosis (MS) who had been treated with natalizumab: A systematic review and meta-analysis
Publication date: Available online 23 September 2019Source: Journal of Clinical NeuroscienceAuthor(s): Amirreza Azimi, Sara Hanaei, Mohammad Ali Sahraian, Mehdi Mohammadifar, Sreeram V. Ramagopalan, Mahsa GhajarzadehAbstractBackgroundNatalizumab is a medication of choice for some patients with relapsing remitting (RR) form of multiple sclerosis (MS). John Cunningham virus (JCV) antibody status is important in cases who are treating with natalizumab. Different studies reported various rates of seroconversion and sero-reversion in patients who had been treated with natalizumab. As there is no systematic review reporting inci...
Source: Journal of Clinical Neuroscience - September 25, 2019 Category: Neuroscience Source Type: research

Diffuse leptomeningeal enhancement in a patient with rapidly progressive dementia: Answer
Publication date: Available online 24 September 2019Source: Journal of Clinical NeuroscienceAuthor(s): Tom J. O'Donohoe, Peter McNeill (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - September 25, 2019 Category: Neuroscience Source Type: research

An atypical presentation of diffuse midline pontine glioma in a middle age patient: Case report
ConclusionOur case shows that diffuse midline glioma is a CNS tumor not limited to young population but occurring also in middle aged patients with an insidious pattern. We therefore recommend to perform biopsy at very early stages in patients with atypical brainstem lesions. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - September 21, 2019 Category: Neuroscience Source Type: research

Development of the functional connectivity of the frontoparietal mirror neuron network in preschool Children: An investigation under resting state
In this study, we investigated the development of the MNS by examining the correlations in spontaneous fluctuations of the functional magnetic resonance imaging (fMRI) blood oxygen level-dependent (BOLD) signal in healthy, 3–5-year-old preschool children (n = 30, 15 in each group). Using a ROI-based (inferior frontal gyrus) functional connectivity analysis, we identified a right lateralized MNS during rest in both groups with a positive correlation between the inferior frontal gyrus and inferior parietal lobule. A significant increase in the functional connectivity of the MNS was observed in the older group. Our ...
Source: Journal of Clinical Neuroscience - September 21, 2019 Category: Neuroscience Source Type: research

Epidemiologic features and risk factors of sepsis in ischemic stroke patients admitted to intensive care: A prospective cohort study
Publication date: Available online 18 September 2019Source: Journal of Clinical NeuroscienceAuthor(s): Yahia Zaid, Abbas Rajeh, Saeed Hosseini Teshnizi, Ali Alqarn, Firoozeh Tarkesh, Zahra Esmaeilinezhad, Reza NikandishAbstractBackground/objectiveStroke is the second leading cause of death globally that predisposed to sepsis. Therefore, this study was aimed to assess the risk factors and epidemiologic features of sepsis in ischemic stroke patients admitted to ICUs.MethodsThroughout this prospective study, we investigated all severe ischemic stroke patients admitted to ICUs of Namazi and Ali-Ashghar Hospitals in Shiraz. Aft...
Source: Journal of Clinical Neuroscience - September 20, 2019 Category: Neuroscience Source Type: research

Predictors of relapse in patients with medication overuse headache in Shanghai: A retrospective study with a 6-month follow-up
This study aimed to determine the predictors of MOH relapse in patients through a 6-month follow-up in Shanghai. In this retrospective study, patients diagnosed with MOH from June 2016 to June 2017 were recruited and followed up for 6 months after withdrawal treatment in Renji Hospital in Shanghai. Patients’ information was obtained using headache questionnaires. Follow-up was conducted via telephone interview. Patients were divided into relapse group and no-relapse group according to the outcomes after 6 months. This study enrolled 124 outpatients with MOH at baseline. 102 patients completed the follow up and we...
Source: Journal of Clinical Neuroscience - September 18, 2019 Category: Neuroscience Source Type: research

Sonographic assessment of the optic nerve and the central retinal artery in idiopathic intracranial hypertension
In this study we assessed the diagnostic usefulness of transorbital sonography in IIH with a special focus on color Doppler imaging of the central retinal artery. IIH patients presented papilledema and enlarged ONSD. ONSD accurately predicted an increased intracranial pressure in IIH (cut-off: 5.8 mm, 81% sensitivity, 80% specificity). 24 h following therapeutic lumbar puncture ONSD diminished significantly, whereas papilledema was not changed. PSV (peak systolic velocity) and Vmean (mean flow velocity) of the central retinal artery were increased in IIH patients compared to controls. PSV accurately predicted an increa...
Source: Journal of Clinical Neuroscience - September 18, 2019 Category: Neuroscience Source Type: research

Is fatigue an important finding in patients with spinocerebellar ataxia type 10 (SCA10)?
Publication date: Available online 17 September 2019Source: Journal of Clinical NeuroscienceAuthor(s): Adriana Moro, Renato Puppi Munhoz, Carlos Henrique Camargo, Mariana Moscovich, Marina Farah, Hélio A.G. TeiveAbstractSpinocerebellar ataxia type 10 (SCA10) is a rare dominantly inherited neurodegenerative disorder characterized by cerebellar ataxia, dysarthria, ocular dysmetria, and seizures in some populations. Fatigue has been described in SCA1, SCA3, but has not been objectively investigated in SCA10. Our aim is to investigate the presence and related causal factors of fatigue among SCA10 patients. Twenty-eight ...
Source: Journal of Clinical Neuroscience - September 18, 2019 Category: Neuroscience Source Type: research

The diagnostic utility of routine clot analysis after endovascular thrombectomy in a patient with systemic lupus erythematosus and antiphospholipid syndrome
We present a case demonstrating histopathological clot findings after endovascular thrombectomy for acute ischaemic stroke in a 38 year-old male with systemic lupus erythematosus and antiphospholipid syndrome (APS). The differential diagnosis was embolism of a suspected Libman-Sacks vegetation or less likely an in-situ thrombosis. Clot analysis provided guidance with patient management and anticoagulation was commenced. The utility of clot analysis in this case provides support for routine clot analysis, which has been standard practice at our institution, and is likely to evolve as endovascular thrombectomy becomes more...
Source: Journal of Clinical Neuroscience - September 18, 2019 Category: Neuroscience Source Type: research

Letter to the editor concerning “Tumor-associated macrophage related interleukin-6 in cerebrospinal fluid as a prognostic marker for glioblastoma”
Publication date: Available online 16 September 2019Source: Journal of Clinical NeuroscienceAuthor(s): Chenghong Wang, Xiaodong Niu, Yanming Ren, Yuekang Zhang (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - September 17, 2019 Category: Neuroscience Source Type: research

Levodopa-responsive parkinsonism in a patient with corticobasal degeneration and bilateral choroid plexus xanthogranulomas
We report an elderly male patient with multiple medical conditions and a family history of essential tremor. He presented with progressive tremor that was initially thought to be essential tremor and later diagnosed as PD despite head computerized tomography showing bilateral intraventricular masses and other minor changes. The clinical diagnosis of PD was supported by his responsiveness to low-dose levodopa. However, postmortem neuropathological examination revealed CBD and bilateral choroid plexus xanthogranulomas with mild ventricular enlargement and multifocal ependymal lining injury presumably due to mild hydrocephalu...
Source: Journal of Clinical Neuroscience - September 17, 2019 Category: Neuroscience Source Type: research

Traumatic brain injuries in a paediatric neurosurgical unit: A Queensland experience
Publication date: Available online 16 September 2019Source: Journal of Clinical NeuroscienceAuthor(s): Sean Stephens, Robert Campbell, Raymond Chaseling, Norman MaAbstractTraumatic brain injury (TBI) is a leading cause of morbidity and mortality in children with a broad injury spectrum and associated continuum in the level of care required. A dearth of data exists regarding children requiring inpatient neurosurgical admission following TBI. A retrospective study of children 0–16 years-old admitted to the neurosurgical unit of a level-1 paediatric trauma hospital in Queensland, Australia following TBI was conducted ...
Source: Journal of Clinical Neuroscience - September 17, 2019 Category: Neuroscience Source Type: research

Minimally invasive trigeminal ablation in patients with refractory trigeminal neuralgia who are ineligible for intracranial intervention
We describe the use of minimally invasive trigeminal ablation, an endoscopic ablative technique to treat trigeminal neuralgia in patients who are traditionally poor surgical candidates. We present 4 patients who presented with refractory unilateral trigeminal neuralgia. Three of the patients had previously failed stereotactic radiosurgery and three of them have multiple sclerosis. Due either to lack of neurovascular compression, minimally invasive trigeminal ablation was offered. Intraoperatively, an incision is made along the buccal mucosa or mid-brow and the tissue is endoscopically dissected in a plane towards the sympt...
Source: Journal of Clinical Neuroscience - September 17, 2019 Category: Neuroscience Source Type: research

Glioma surgery: From preservation of motor skills to conservation of cognitive functions
Publication date: Available online 16 September 2019Source: Journal of Clinical NeuroscienceAuthor(s): Roberto Altieri, Simona Raimondo, Cristiana Tiddia, Diego Sammarco, Fabio Cofano, Pietro Zeppa, Matteo Monticelli, Antonio Melcarne, Carola Junemann, Francesco Zenga, Riccardo Savastano, Diego Garbossa, Francesco Certo, Giuseppe BarbagalloAbstractThe first step of glioma treatment is surgery. Extent of resection (EOR) improves patient survival if surgery does not negatively impair a patient’s neurological status. However, how surgery affects the patient’s quality of life (QOL) has been less studied, especially...
Source: Journal of Clinical Neuroscience - September 17, 2019 Category: Neuroscience Source Type: research

Simultaneous MR neurography and apparent T2 mapping of cervical nerve roots before microendoscopic surgery to treat patient with radiculopathy due to cervical disc herniation: Preliminary results
Publication date: Available online 13 September 2019Source: Journal of Clinical NeuroscienceAuthor(s): Yawara Eguchi, Keigo Enomoto, Takashi Sato, Atsuya Watanabe, Takayuki Sakai, Masaki Norimoto, Masami Yoneyama, Yasuchika Aoki, Munetaka Suzuki, Hajime Yamanaka, Hiroshi Tamai, Tatsuya Kobayashi, Sumihisa Orita, Miyako Suzuki, Kazuhide Inage, Yasuhiro Shiga, Naoya Hirosawa, Masahiro Inoue, Masao Koda, Takeo FuruyaAbstractThere is no imaging modality to quantitatively evaluate compressed cervical nerve roots in cervical radiculopathy. Here we sought to evaluate the usefulness of simultaneous apparent T2 mapping and neurogra...
Source: Journal of Clinical Neuroscience - September 15, 2019 Category: Neuroscience Source Type: research

Ruptured intracranial aneurysm in a neonate
Publication date: Available online 13 September 2019Source: Journal of Clinical NeuroscienceAuthor(s): Alejandro Santillan, Kenroy Brown, Athos Patsalides (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - September 15, 2019 Category: Neuroscience Source Type: research

The effects of exercise interventions on Parkinson’s disease: A Bayesian network meta-analysis
ConclusionTango was an optimal and effective option for improving functional mobility of PD patients. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - September 15, 2019 Category: Neuroscience Source Type: research

Photosensitive epilepsy and photosensitivity of patients with possible epilepsy in Chinese Han race: A prospective multicenter study
Publication date: Available online 13 September 2019Source: Journal of Clinical NeuroscienceAuthor(s): Jie Bai, Wen-Juan Zhang, Zhi-Fang Ruan, Bei-Bei Chen, Gang Zhao, Dong Wang, Jing-Xia Dang, Yong-Hong LiuAbstractPhotosensitive is probably caused by multiple factors including gender, familiar, etc. We aim to study the clinical and EEG features of Chinese Han patients with photosensitivity. A total of 5482 consecutive patients with possible epilepsy from 3 center in China. Of the 73 patients with PPR to IPS, 48 were female. 69.9% patients were evoked by frequency ranged 8 Hz–25 Hz, with accompanying seizures in ...
Source: Journal of Clinical Neuroscience - September 15, 2019 Category: Neuroscience Source Type: research

Navigated minimally invasive facet fusion during percutaneous lumbar pedicle screw insertion: Technical note
ConclusionsIt is possible to add posterior arthrodesis to percutaneous lumbar pedicle screw fusion with few added steps and minimal addition of time using navigation and MIS tubular retractors. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - September 12, 2019 Category: Neuroscience Source Type: research

Misleading non-epileptic epileptiform activities on intracranial recordings
Publication date: Available online 11 September 2019Source: Journal of Clinical NeuroscienceAuthor(s): Ayaka Sasagawa, Rei Enatsu, Hime Suzuki, Rintaro Yokoyama, Tsukasa Hirano, Masayasu Arihara, Tomoyoshi Kuribara, Satoko Ochi, Nobuhiro MikuniAbstractNumerous non-epileptic physiological electroencephalographic (EEG) patterns morphologically mimic epileptiform activity. However, misleading non-epileptic findings of electrocorticography (ECoG) have not yet been examined in detail. The aim of the present study was to identify non-epileptic epileptiform ECoG findings. We retrospectively reviewed the intracranial recordings of...
Source: Journal of Clinical Neuroscience - September 12, 2019 Category: Neuroscience Source Type: research

The effect of HMG-CoA reductase inhibitors on thrombolysis-induced haemorrhagic transformation
Publication date: Available online 11 September 2019Source: Journal of Clinical NeuroscienceAuthor(s): Yousheng Wu, Dan Lu, Anding XuAbstractThrombolysis-induced haemorrhagic transformation is the most challenging preventable complication in thrombolytic therapy. This condition is often associated with poor functional outcome and long-term disease burden. Statins, or 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, are controversially suggested to either increase or decrease the odds of better primary outcomes compared to treatment without statins after thrombolysis in patients or animals; statins are ...
Source: Journal of Clinical Neuroscience - September 12, 2019 Category: Neuroscience Source Type: research

Effects of handwriting exercise on functional outcome in Parkinson disease: A randomized controlled trial
This study aimed to determine whether handwriting exercise could improve fine manual motor function in PD. The study was a randomized controlled trial assessing the efficacy of a 4-week handwriting exercise using a newly developed handwriting practice book. The primary endpoint was an improvement in the time used to complete the handwriting test. Secondary endpoints were accuracy of the writing performance, patient’s subjective rating scale of their handwriting and a UPDRS part III motor examination. Of a total of 46 subjects, 23 were randomly assigned to the handwriting exercise group. After 4 weeks, the mean time...
Source: Journal of Clinical Neuroscience - September 9, 2019 Category: Neuroscience Source Type: research

“Sequential multimodality stimulation” for post-stroke-hemineglect: Feasibility and outcome in a pilot randomized controlled trial
ConclusionMultimodality stimulation, in addition to standard physiotherapy, is feasible and potentially results in better neurocognitive and functional recovery following right hemispheric ischemic strokes. However, larger studies are warranted to prove these preliminary observations beyond doubt. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - September 6, 2019 Category: Neuroscience Source Type: research

Efficacy of RehaCom cognitive rehabilitation software in activities of daily living, attention and response control in chronic stroke patients
ConclusionsIn conclusion, RehaCom cognitive rehabilitation software has improvement effect on ADL, attention and response control in patients with chronic stroke. Our study reveals a new information about the efficacy of computerized training in the rehabilitation of stroke patients. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - September 6, 2019 Category: Neuroscience Source Type: research

Can initial sarcopenia affect poststroke rehabilitation outcome?
This study investigated the association between the presence of sarcopenia, measured by nonhemiplegic grip strength, and the level of functional recovery, measured by the modified Rankin Scale (mRS) at six months after stroke. We performed a retrospective cohort analysis of a prospectively maintained database of 194 hemiplegic poststroke patients, who had been admitted to the Department of Rehabilitation Medicine of a university-affiliated hospital. At 6 months after stroke, 72.2% of patients had mRS score>3, with more women (81.0% vs. 66.0%, p = 0.024) showing poor recovery. Both men (51.3% vs. 35.9%, p = 0.0...
Source: Journal of Clinical Neuroscience - September 6, 2019 Category: Neuroscience Source Type: research

Quantitative 3-dimensional Computed Tomography (Q3DCT) analysis of odontoid fractures
Publication date: Available online 5 September 2019Source: Journal of Clinical NeuroscienceAuthor(s): Bianca M. Verbeek, Stein J. Janssen, Bart J. Pielkenrood, Joseph H. SchwabAbstractThe primary aim of this paper is to introduce Quantitative 3-dimensional Computed Tomography (Q3DCT) for odontoid fractures to assess if fracture characteristics differ between the Anderson and d’Alonso subclasses. Secondarily, we assessed if high energy injury and older age influenced fracture morphology. This retrospective imaging study includes 66 patients who visited one of two level I trauma centers for an odontoid fracture. With t...
Source: Journal of Clinical Neuroscience - September 6, 2019 Category: Neuroscience Source Type: research

Impact of obesity on restoration of sagittal balance and clinical efficacy after posterior lumbar interbody fusion
Publication date: Available online 5 September 2019Source: Journal of Clinical NeuroscienceAuthor(s): Yijian Zhang, Junxin Zhang, Hao Liu, Yijie Shao, Fan He, Angela Chen, Huilin Yang, Bin PiAbstractTo investigate the impact of obesity on the restoration of sagittal balance after posterior lumbar interbody fusion (PLIF). To examine the correlation between obesity and sagittal balance and their influence on clinical efficacy. A total of 183 patients who underwent PLIF for degenerative lumbar diseases between Jan 2015 and Dec 2015 were enrolled in this study. Based on their BMI, patients were divided into three groups: norma...
Source: Journal of Clinical Neuroscience - September 6, 2019 Category: Neuroscience Source Type: research

Aggressive course of cognitive impairment in multiple sclerosis: A new term for the management of patients
Publication date: Available online 5 September 2019Source: Journal of Clinical NeuroscienceAuthor(s): Abdorreza Naser Moghadasi, Mohammad Ali SahraianAbstractMultiple sclerosis (MS) can create different kinds of symptoms by involving different fields of the central nervous system. Cognitive impairment (CI) is one of the symptoms that can be caused by the onset of the disease and provide a change in the patient’s quality of life. Considering the course of the disease, CI usually worsens increasingly, and there is usually a severe CI in patients with end stage of MS. However, progressing CI can be so fast and severe in...
Source: Journal of Clinical Neuroscience - September 6, 2019 Category: Neuroscience Source Type: research

Intraoperative neuromonitoring for one-level lumbar discectomies is low yield and cost-ineffective
ConclusionsNeuromonitoring for lumbar discectomy confers greater operative time and cost, without any difference in neurological outcome. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - September 6, 2019 Category: Neuroscience Source Type: research

Musculoskeletal problems in PD patients have no association with socioeconomic status
Publication date: Available online 6 September 2019Source: Journal of Clinical NeuroscienceAuthor(s): Ahro Kim, Aryun Kim, Yoon Kim, Young Eun Kim, Han-Joon Kim, Beomseok JeonAbstractMusculoskeletal problems are common in the general population and also in Parkinson’s disease (PD) patients. We aimed to assess whether socioeconomic status (SES) is associated with the prevalence of musculoskeletal problems in PD patients.This cross-sectional study used data a total of 309 patients with PD who were interviewed, and their medical records were reviewed from the Movement Disorder Clinic of Seoul National University Hospita...
Source: Journal of Clinical Neuroscience - September 6, 2019 Category: Neuroscience Source Type: research

Infantile neuroaxonal dystrophy in a pair of Malaysian siblings with progressive cerebellar atrophy: Description of an expanded phenotype with novel PLA2A6 variants
We report our diagnostic approach of a pair of siblings with psychomotor regression, hypotonia, optic atrophy and auditory neuropathy. The brain magnetic resonance imaging (MRI) showed progressive cerebellar atrophy. Genetic testing of the PLA2G6 confirmed presence of compound heterozygous novel mutations. As the variant c. 196C>T (p.Gln66X) was a truncating variant, it was considered as pathogenic while the variant c. 2249G>A (p. Cys750Tyr) was considered as “likely pathogenic” by bioinformatics analyses. Our patient expands the clinical phenotype of INAD as it described the first South-East Asian patien...
Source: Journal of Clinical Neuroscience - September 5, 2019 Category: Neuroscience Source Type: research

Early prediction of clinical outcomes in patients with aneurysmal subarachnoid hemorrhage using computed tomography texture analysis
Publication date: Available online 4 September 2019Source: Journal of Clinical NeuroscienceAuthor(s): Tokunori Kanazawa, Satoshi Takahashi, Yasuhiro Minami, Masahiro Jinzaki, Masahiro Toda, Kazunari YoshidaAbstractRadiological evaluation of subarachnoid hemorrhage (SAH) is often subject to interobserver variability. The aim of this study was to retrospectively detect computed tomography (CT) texture parameters in the early postictal state to predict cerebral vasospasm, delayed cerebral ischemia (DCI), and functional outcome in aneurysmal SAH using quantitative CT texture analysis (CTTA) via a commercially available softwar...
Source: Journal of Clinical Neuroscience - September 5, 2019 Category: Neuroscience Source Type: research

Anatomical study of the ventral neurovascular structures and hypoglossal canal for the surgery of the upper cervical spine
Publication date: Available online 4 September 2019Source: Journal of Clinical NeuroscienceAuthor(s): Jae Taek Hong, Alejandro A. Espinoza Orías, Howard S. AnAbstractThe aim of this study is to evaluate the anatomical relationship between the bony structures and ventral neurovascular structures around craniovertebral junction (CVJ).Eleven fresh-frozen cadaveric specimens were dissected around CVJ. The anatomical relationships were evaluated between C1 bony structures (midline, lateral margin of the C1 lateral mass (LM) and C1 transverse process (TP)) and ventral neurovascular structure such as ICA and HN. Morphometr...
Source: Journal of Clinical Neuroscience - September 5, 2019 Category: Neuroscience Source Type: research

Nerve high-resolution ultrasonography in peripheral nerve injuries associated with supracondylar humeral fractures in children
Publication date: Available online 4 September 2019Source: Journal of Clinical NeuroscienceAuthor(s): Luca Leonardi, Simona Loreti, Antonella Di Pasquale, Stefania Morino, Laura Fionda, Fiammetta Vanoli, Matteo Garibaldi, Giovanni AntoniniAbstractTo evaluate nerve high-resolution ultrasonography (HRUS) as diagnostic tool in children with supracondylar humeral fractures (SHF)-related peripheral nerve injuries (PNIs), we selected at least one illustrative case for each upper limb nerve usually involved in SHF (i.e. median, radial and ulnar nerve), in which HRUS evaluation added a useful contribution in diagnostic and therape...
Source: Journal of Clinical Neuroscience - September 5, 2019 Category: Neuroscience Source Type: research

Leptin in adolescent idiopathic scoliosis – A meta-analysis
Publication date: Available online 4 September 2019Source: Journal of Clinical NeuroscienceAuthor(s): Seong Ho Bae, Tae Sik Goh, Dong Suk Kim, Jung Sub LeeAbstractTo compare the serum levels of leptin and soluble leptin receptor (sOB-R) with adolescent idiopathic scoliosis (AIS) girls and controls through meta-analysis. The MEDLINE via PubMed, Cochrane, Scopus, and EMBASE database, from the earliest available date of indexing between January 2010 and January 2019, were searched for comparative studies evaluating serum levels of leptin and sOB-R in AIS girls. Two authors performed the data extraction independently. Any disc...
Source: Journal of Clinical Neuroscience - September 5, 2019 Category: Neuroscience Source Type: research

Efficacy and tolerability of subcutaneously administered immunoglobulin in myasthenia gravis: A systematic review
The objective of this study is to determine the efficacy and safety of SCIg in the treatment of adult patients with myasthenia gravis. Relevant records were identified from August 2018 to January 2019 systematic search. Five relevant articles with a total of 34 patients with MG were included in this review. Data on functional disability score and adverse events were obtained. Based on the included uncontrolled studies, the functional disability scores of adult MG patients after SCIg administration showed consistent improvement. Headache and local site injection reactions were the most common adverse events reported. The ev...
Source: Journal of Clinical Neuroscience - September 5, 2019 Category: Neuroscience Source Type: research

Single loop interrupted suture technique for cerebrovascular anastomosis: Technical note
Publication date: Available online 4 September 2019Source: Journal of Clinical NeuroscienceAuthor(s): Satoshi Matsuo, Toshiyuki Amano, Akira NakamizoAbstractThe ideal suturing technique for cerebrovascular anastomosis remains a point of debate. Although simple interrupted sutures are considered to achieve higher patency, they require longer anastomosis time compared with running sutures. The authors describe a novel techniques named single loop interrupted suture to place interrupted sutures for cerebrovascular anastomosis. The single loop interrupted suture technique consists of repeatedly placing, tying and cutting a sin...
Source: Journal of Clinical Neuroscience - September 5, 2019 Category: Neuroscience Source Type: research

Memory loss and confusion: Answer
Publication date: Available online 3 September 2019Source: Journal of Clinical NeuroscienceAuthor(s): A. Lasocki (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - September 4, 2019 Category: Neuroscience Source Type: research

Favourable outcome without psychotherapy in patients with functional neurologic disorder
ConclusionOur study confirms the results of the retrospective study. The association between a high level of somatisation and a less favourable outcome suggests that neurologists should pay more attention to symptoms other than the neurological, but this does not necessarily mean referral for a psychological intervention. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - September 4, 2019 Category: Neuroscience Source Type: research

Postoperative 30-day outcomes after craniotomy for supratentorial AVM resection in children
Publication date: Available online 3 September 2019Source: Journal of Clinical NeuroscienceAuthor(s): Matthew Muir, Rajan Patel, Nisha Gadgil, Iwen Pan, Sandi LamAbstractPurposeTo describe 30-day outcomes following craniotomy for arteriovenous malformation in children and identify risk factors for readmission, reoperation, and perioperative complication using the National Surgical Quality Improvement Program (NSQIP) Pediatric database.MethodsPatients aged 0–18 years who underwent surgery for arteriovenous malformations (years 2015–2016) were identified from the NSQIP Pediatric database. Descriptive statistics...
Source: Journal of Clinical Neuroscience - September 4, 2019 Category: Neuroscience Source Type: research

Preliminary study of hsa-miR-626 change in the cerebrospinal fluid of Parkinson’s disease patients
Publication date: Available online 3 September 2019Source: Journal of Clinical NeuroscienceAuthor(s): Li-xia Qin, Jie-qiong Tan, Hai-nan Zhang, Jian-guang Tang, Bo Jiang, Xiang-min Shen, Bei-sha Tang, Chun-yu WangAbstractmicroRNAs have been reported to suppress tumor growth, invasion, and metastasis and play roles in neurodegeneration disorders. Moreover, changes in microRNAs are found in the peripheral blood, cerebrospinal fluid (CSF), and brain tissues in patients of central nervous system diseases, including glioma, Alzheimer’s disease (AD), Parkinson’s disease (PD), multiple sclerosis and depression. Compar...
Source: Journal of Clinical Neuroscience - September 4, 2019 Category: Neuroscience Source Type: research

Prospective randomized placebo-controlled double-blind clinical study of adjuvant dexamethasone with surgery for chronic subdural haematoma with post-operative subdural drainage: Interim analysis
ConclusionsIn this first registered PRPCT, interim analysis suggested that adjuvant DX with post-operative drainage is both safe and may significantly decrease recurrences. A 12.5% point between-groups difference may be reasonable to power a final sample size of approximately n = 89. Future studies could consider adjuvant DX for longer than the arbitrarily-chosen 2 weeks. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - September 4, 2019 Category: Neuroscience Source Type: research

Procedural outcomes of deep brain stimulation (DBS) surgery in rural and urban patient population settings
Publication date: Available online 3 September 2019Source: Journal of Clinical NeuroscienceAuthor(s): Michael Fana, Gregory Everett, Thomas Fagan, Megan Mazzella, Sulmaz Zahedi, John M. ClementsAbstractPresently, disparities exist between race, sex, socioeconomic status, hospitals, income, comorbidities, and insurance profiles of patients undergoing DBS surgery. Here, we aim to highlight several variables and their predictive powers of DBS surgery outcomes as measured by discharge location, length of hospital stays, and total hospital charges. A retrospective cohort study using discharge data from NIS and HCUP for ana...
Source: Journal of Clinical Neuroscience - September 4, 2019 Category: Neuroscience Source Type: research

Effects of preoperative 5-aminolevulinic acid administration on postoperative liver enzymes after brain tumor surgery in patients with elevated preoperative liver enzymes
Publication date: Available online 4 September 2019Source: Journal of Clinical NeuroscienceAuthor(s): Hyongmin Oh, Jung-Bin Park, Hyun-Kyu Yoon, Hyung-Chul Lee, Chul-Kee Park, Hee-Pyoung ParkAbstractThe effect of 5-aminolevulinic acid (5-ALA) on a postoperative increase in liver enzymes (PILE) has not been clearly investigated in patients with elevated preoperative liver enzymes. The aim of this study was to evaluate the safety of 5-ALA in brain tumor patients with elevated preoperative liver enzymes by investigating the incidence, severity, and duration of PILE. This retrospective study was conducted in patients with a br...
Source: Journal of Clinical Neuroscience - September 4, 2019 Category: Neuroscience Source Type: research