Evaluation of retraction time as a predictor of postoperative motor dysfunction after minimally invasive transpsoas interbody fusion at L4-L5
ConclusionThe results of this study suggest that longer retraction time (within a range of 14–51 min) did not correlate with a greater risk of postoperative neuropathic quadriceps muscle dysfunction for lateral lumbar interbody fusions performed at L4-5. Other factors may contribute to postoperative neurologic dysfunction regardless of RT. Motor deficits resolved quickly after surgery. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - December 12, 2018 Category: Neuroscience Source Type: research

Cold effect in median nerve conductions in clinical carpal tunnel syndrome with normal nerve conduction studies
Publication date: Available online 8 December 2018Source: Journal of Clinical NeuroscienceAuthor(s): Bahar Say, Ufuk Ergün, Ebru Turgal, İlknur YardımcıAbstractClinical diagnosis of carpal tunnel syndrome (CTS) is confirmed by nerve conduction studies (NCS). In some cases, NCS may be normal. We aimed to demonstrate changes of distal motor latency (DML) and nerve conduction velocity (NCV) pathology of demyelination in entrapment neuropathy with cold application in case of clinical CTS with normal NCS. This prospective, cross-sectional, randomise, case-control involved 15 patients (25 hands) with clinically definite ...
Source: Journal of Clinical Neuroscience - December 9, 2018 Category: Neuroscience Source Type: research

A rare case report of a mixed persistent proatlantal intersegmental artery
We present a case of a special type of PPIA that was in a 57-year-old man who presented with dizziness and episodic vertigo of 9 months duration. The diagnosis relied on computed tomography angiography and digital subtraction angiography, by which a left internal carotid artery stenosis and an ipsilateral PPIA originating from the external carotid artery (ECA) was found. This special type of PPIA can be described as a ‘‘mixed PPIA’’ that originated as Type II from the ECA and coursed as Type I. The patient underwent carotid artery stenting and had no relapse during 3 months follow-up. In additio...
Source: Journal of Clinical Neuroscience - December 6, 2018 Category: Neuroscience Source Type: research

Prognostic factors and survival in low grade gliomas of the spinal cord: A population-based analysis from 2006 to 2012
This study used a large cohort of low-grade spinal cord astrocytomas to determine the effectiveness of prognostic factors and survival.MethodsThe Surveillance, Epidemiology, and End Results (SEER) cancer registry was used to identify patients with WHO grade I-II primary spinal cord astrocytomas from 1973 to 2012; however, patients before 2006 were excluded due to ambiguity diagnosis. Univariate and multivariate Cox proportional hazard models were created to compare survival across covariates and summarized using the Kaplan-Meier method.ResultsA total of 561 patients with low-grade glioma (astrocytoma) were identified. Amon...
Source: Journal of Clinical Neuroscience - December 6, 2018 Category: Neuroscience Source Type: research

The diagnostic accuracy of somatosensory evoked potentials in evaluating neurological deficits during 1057 lumbar interbody fusions
ConclusionsSignificant SSEP changes during LIF are a very specific but poorly sensitive indicator of perioperative neurological deficits. The odds ratio for LE loss of responses was 29.14 with a 95% CI of 1.79-475.5, so LE SSEP loss of responses can serve as a biomarker of perioperative neurological deficits after LIF. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - December 5, 2018 Category: Neuroscience Source Type: research

EEG entropy analysis in autistic children
In this study, we investigated four entropy methods to analyse the resting-state EEG of the autistic children and the typical development (TD) children. Through 43 children diagnosed with autism aged from 4 to 8 years old as compared to 43 normal children matched for age and gender, we found region-specifically and entropy-specifically which were more sensitive with the increase of age. In detail, for 4 years old group, there is significant difference in central by Renyi permutation entropy method; the significant differences are in frontal and central by sample entropy for 5 years old group; the significant differen...
Source: Journal of Clinical Neuroscience - November 29, 2018 Category: Neuroscience Source Type: research

Mirth and laughter induced by electrical stimulation of the posterior insula
Publication date: Available online 27 November 2018Source: Journal of Clinical NeuroscienceAuthor(s): Hao Yan, Chang Liu, Tao Yu, Kaijia Yu, CuiPing Xu, Xueyuan Wang, Duanyu Ni, Yongjie LiAbstractLaughter induced in the insula is uncommon. In this case-report we present a description of a patient with drug-resistant focal epilepsy for whom laughter with mirth was elicited when the posterior insula (PI) was stimulated by intracranial electrodes. We attempted to analyze the progression of laughter in the insula and suggest a possible pathway for the expression of laughter. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - November 28, 2018 Category: Neuroscience Source Type: research

EMG in piriformis syndrome diagnosis: Reliability of peroneal H-reflex according to results obtained after surgery, Botox injection and medical treatment
Publication date: Available online 28 November 2018Source: Journal of Clinical NeuroscienceAuthor(s): Hassan Najdi, Dany Mouarbes, Joe Abi-akl, Soha Karnib, Ali Hassan Chamsedine, Roger JawishAbstractDiagnosing piriformis syndrome (PS) throughout the past decades was not that easy, however peroneal H-reflex was proved as reliable test for PS with the change in wave amplitude and delay in conduction as parameters for diagnosis. We interpreted these parameters according to treatment’s results carried out for patients presenting clinical PS, aiming to define a threshold value for peroneal H-reflex delay to accurately di...
Source: Journal of Clinical Neuroscience - November 28, 2018 Category: Neuroscience Source Type: research

Two-site blind epidural blood patch versus targeted epidural blood patch in spontaneous intracranial hypotension
Publication date: Available online 26 November 2018Source: Journal of Clinical NeuroscienceAuthor(s): Curie Ahn, Eugene Lee, Joon Woo Lee, Choong Guen Chee, Yusuhn Kang, Heung Sik KangAbstractSpontaneous intracranial hypotension (SIH), caused by CSF leaks, can trigger headaches, and is treated using epidural blood patch (EBP) procedures. We aimed to determine the effectiveness of a newly devised two-site blind EBP procedure as the initial treatment for SIH and compare its effectiveness with that of conventional targeted EBP.We retrospectively reviewed data for 116 patients who underwent EBP for SIH between November 2013 an...
Source: Journal of Clinical Neuroscience - November 27, 2018 Category: Neuroscience Source Type: research

Magnetic resonance characterization of the ‘dot sign’ in colloid cysts of the third ventricle
ConclusionsAn intracystic low T2 ‘dot’ is a common MRI feature of colloid cysts of the third ventricle, and to our knowledge not previously systematically described. Presence of such a dot should not only not dissuade from a diagnosis of colloid cyst being made, but should in fact be used to strengthen the imaging diagnosis. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - November 27, 2018 Category: Neuroscience Source Type: research

A retrospective analysis of chronic subdural haematoma recurrence rates following burr hole trephination versus minicraniotomy
Publication date: Available online 26 November 2018Source: Journal of Clinical NeuroscienceAuthor(s): S. Haron, N. Bogduk, M. HansenAbstractThe aim of this study was to determine the subdural haematoma recurrence rate in patients with symptomatic chronic subdural haematomas (CSDH) treated with either burr hole trephination (BHT) or minicraniotomy (MC) and to determine whether a statistically significant difference exists between the two techniques. A retrospective analysis of all consecutive patients with symptomatic CSDH treated with BHT or MC at the John Hunter Hospital Neurosurgery Department between July 2004 and July ...
Source: Journal of Clinical Neuroscience - November 26, 2018 Category: Neuroscience Source Type: research

Imaging findings after acute sport-related concussion in American football players: A systematic review
Publication date: Available online 26 November 2018Source: Journal of Clinical NeuroscienceAuthor(s): Steve H. Monk, Andrew D. Legarreta, Paul Kirby, Benjamin L. Brett, Aaron M. Yengo-Kahn, Aashim Bhatia, Gary S. Solomon, Scott L. ZuckermanAbstractSport-related concussion (SRC) has emerged as a major public health problem. The results of brain imaging studies following SRC have raised questions about long-term neurologic health, but the clinical implications of these findings remain unknown. A systematic review of brain imaging findings after SRC was performed utilizing the following inclusion criteria: football players, b...
Source: Journal of Clinical Neuroscience - November 26, 2018 Category: Neuroscience Source Type: research

Abnormal level of consciousness predicts outcomes of patients with anti-NMDA encephalitis
Publication date: Available online 24 November 2018Source: Journal of Clinical NeuroscienceAuthor(s): Saharat Aungsumart, Atina Ha, Metha ApiwattanakulAbstractAnti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis is an acute form of encephalitis with an autoimmune etiology. We aimed to study clinical characteristics and treatment outcomes and assess the predictive factors associated with patient outcome. In this retrospective study, patients who presented with cardinal symptoms of anti-NMDA encephalitis and positive anti-NMDA receptor antibody results in their cerebrospinal fluid were included in the study. Thirty-o...
Source: Journal of Clinical Neuroscience - November 25, 2018 Category: Neuroscience Source Type: research

Plasma and CSF miRNA dysregulations in subarachnoid hemorrhage reveal clinical courses and underlying pathways
ConclusionsClinical progression of SAH is associated with different miRNA fingerprints. They carry neuro-pathological relevance and can be a potential biomarker which compliments SAH management. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - November 25, 2018 Category: Neuroscience Source Type: research

Outcomes of patients with Guillain Barre Syndrome – Experience from a tertiary care hospital of a developing Asian country and review of regional literature
Publication date: Available online 23 November 2018Source: Journal of Clinical NeuroscienceAuthor(s): Sarah H Siddiqui, Tahira H Siddiqui, Masood U Babar, Adeel Khoja, Sara KhanAbstractOutcomes of Guillain Barre Syndrome (GBS), particularly those require mechanical ventilation have been reported from a number of Asian countries, albeit, scarcely from Pakistan. We conducted this study to determine the short-term outcomes of GBS and compare the results of mechanically ventilated and non-ventilated patients. Case records of patients admitted with GBS during 2011–2016 at a large tertiary care centre of Pakistan were retr...
Source: Journal of Clinical Neuroscience - November 24, 2018 Category: Neuroscience Source Type: research

An unusual case with vertical supranuclear gaze palsy
Publication date: Available online 23 November 2018Source: Journal of Clinical NeuroscienceAuthor(s): Chaewon Shin, Tae-Beom Ahn (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - November 24, 2018 Category: Neuroscience Source Type: research

Reconstructing patient-specific cerebral aneurysm vasculature for in vitro investigations and treatment efficacy assessments
In this study, in vitro models were created from three-dimensional rotational angiography (3DRA) of six patients harboring intracranial aneurysms using a multi-step process involving 3D printing, index of refraction matching and silicone casting that renders the models transparent for flow visualization. Each model was treated with the same commercially-available, patient-specific, endovascular devices (coils and/or stents). All models were scanned by synchrotron X-ray microtomography to obtain high-resolution imaging of the vessel lumen, aneurysmal sac and endovascular devices. Dimensional accuracy was compared by quantif...
Source: Journal of Clinical Neuroscience - November 23, 2018 Category: Neuroscience Source Type: research

Clinical-radiographic correlates of Artery of Percheron infarcts in a case series of 6 patients
We describe a series of 6 patients who present with varying levels of somnolence and oculomotor nerve palsies who had an occlusion of the AOP with bilateral thalamic infarcts with midbrain involvement. These clinical presentations, combined with the “V” sign on MRI are important in making the diagnosis. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - November 23, 2018 Category: Neuroscience Source Type: research

Hypoglossal schwannomas: A systematic review of the literature
ConclusionCurrent evidence suggests overall favorable outcomes with surgical resection of hypoglossal schwannomas, with a large percentage of patients experiencing mild and usually well-tolerated neurologic deficit. Limitations of this study include the use of retrospective data taken from case reports/series with highly selected patients, selective reporting, and absence of control groups. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - November 23, 2018 Category: Neuroscience Source Type: research

Peri-electrode edema after deep brain stimulation
Publication date: Available online 22 November 2018Source: Journal of Clinical NeuroscienceAuthor(s): Takuro Saitoh, Rei Enatsu, Takeshi Mikami, Yuto Suzuki, Aya Kanno, Mayumi Kitagawa, Nobuhiro MikuniAbstractPeri-electrode edema can occur after deep brain stimulation (DBS). The diagnosis and management of peri-electrode edema may be challenging. We herein report non-infectious peri-electrode edema after the placement of DBS electrodes in patients with Parkinson’s disease (PD). Fifteen patients who underwent DBS surgery between 2010 and 2018 at Sapporo Medical University were included to identify post-operative peri-...
Source: Journal of Clinical Neuroscience - November 23, 2018 Category: Neuroscience Source Type: research

Establishment and 12-month progress of the New Zealand Motor Neurone Disease Registry
We report anonymised aggregated data from the first year’s enrolment.12th July 2018, there were 142 participants enrolled in the NZ MND Registry. Participant sex distribution reflects the demographics reported worldwide, but ethnicity is divergent from what is seen in New Zealand overall, with an over-representation of people who identify as New Zealand European. 85.5% of participants are diagnosed with sporadic MND and 6.1% with familial MND. The remainder were participants who have not been diagnosed but have a family history, or positive genetic test for a MND-causing mutation. Levels of disability are reported us...
Source: Journal of Clinical Neuroscience - November 23, 2018 Category: Neuroscience Source Type: research

Splitting of the semispinalis capitis muscle as a less invasive approach for atlantoaxial fusion – A technical note
ConclusionMinimal invasive splitting of the semispinalis capitis muscle allows adequate exposure of the screw entry points of C1, C1/C2 and C2 while preserving the intrinsic muscles of the back at the craniocervical junction. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - November 23, 2018 Category: Neuroscience Source Type: research

Secondary sacral tethered cord syndrome after treatment of secondary cervical syringomyelia
Publication date: Available online 22 November 2018Source: Journal of Clinical NeuroscienceAuthor(s): Arthur Gubian, Steffen K. RosahlAbstractA female patient operated at the age of 11 on a pilocytic astrocytoma in the posterior fossa, was re-operated for a recurrence 9 years later. A Torkildsen drain was placed in the 4th ventricle and she remained asymptomatic for 15 years before presenting again with acute hydrocephalus, tonsillar herniation, and a massive cervicothoracic syrinx. The symptoms retreated following craniocervical untethering and decompression. Two weeks later, however, she suffered from debilitating ra...
Source: Journal of Clinical Neuroscience - November 23, 2018 Category: Neuroscience Source Type: research

Evaluating the suitability of the Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT) computerized neurocognitive battery for short-term, serial assessment of neurocognitive functioning
ConclusionThe ICCs for ImPACT composite and factor scores across the one-hour administration were consistent with previous studies. Only a small percentage of scores fell outside of RCI and RBM cutoffs. These statistical metrics suggest that ImPACT has sufficient reliability when repeating administration within one-hour. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - November 23, 2018 Category: Neuroscience Source Type: research

0.075% capsaicin lotion for the treatment of painful diabetic neuropathy: A randomized, double-blind, crossover, placebo-controlled trial
ConclusionIn patients with PDN, the efficacy of 0.075% capsaicin lotion was similar to placebo but was well tolerated. More work is needed to assess different capsaicin formulations. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - November 23, 2018 Category: Neuroscience Source Type: research

Cervical paraspinal muscle compartment pressure after laminoplasty: A cadaveric study
Publication date: Available online 22 November 2018Source: Journal of Clinical NeuroscienceAuthor(s): Weerasak Singhatanadgige, Yuttagarn Suebsombut, K. Daniel Riew, Chotetawan Tanavalee, Wicharn Yingsakmongkol, Worawat LimthongkulAbstractAxial neck pain is a common complaint after cervical laminoplasty and the causes are still not well-understood. We hypothesized that abnormal paracervical muscle compartment pressures might be one of them. The cervical paraspinal muscle compartment pressures of 10 cadavers were measured in six different areas under four different conditions. The posterior cervical area was divided into tw...
Source: Journal of Clinical Neuroscience - November 23, 2018 Category: Neuroscience Source Type: research

Primary intraspinal non-Hodgkin’s lymphoma: Case report and review of literature
We present the unique case of an 67-year-old female patient with primary intraspinal B-cell non-Hodgkin’s lymphoma without cerebral manifestation mimicking myelitis in clinical presentation and neuroradiological diagnostic. It illustrates the broad spectrum of differential diagnoses for paraplegia and the importance of rapid interdisciplinary diagnostic work-up since the neurologic status after treatment mainly depends on the delay of treatment. Review of existing literature suggests combined radio- and chemotherapy as well as high-dose intravenous methotrexate or rituximab. The rising incidence of spinal lymphomas e...
Source: Journal of Clinical Neuroscience - November 23, 2018 Category: Neuroscience Source Type: research

Glioblastoma with bilateral extraocular muscle infiltration preceded by evidence of vascular tropism
We present a case of bilateral synchronous orbital muscle infiltration of extra-neural glioblastoma metastases with evidence of focal treatment response. The orbital infiltration was preceded by evidence of leptomeningeal disease, and followed by further symptomatic perineural spread of tumor along the second and third division of the trigeminal nerve and into the masticator space. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - November 23, 2018 Category: Neuroscience Source Type: research

Transcranial color-coded sonography findings of patients with reversible cerebral vasoconstriction syndromes
We report herein 2 cases with RCVS in which we clarified temporal changes in vessel vasoconstriction in detail using transcranial color-coded sonography (TCCS). The first case involved a 27-year-old woman who developed intracerebral hemorrhage (ICH) and subarachnoid hemorrhage (SAH) after severe headache. TCCS showed peak systolic velocity (PSV) in the left middle cerebral artery (MCA) peaked at 212 cm/s on day 6 and gradually decreased, whereas PSV of the left posterior cerebral artery (PCA) and left anterior cerebral artery (ACA) re-elevated to 190 cm/s on day 15. The second case involved a 53-year-old woman who deve...
Source: Journal of Clinical Neuroscience - November 23, 2018 Category: Neuroscience Source Type: research

Neuroendoscopic hematoma removal with a small craniotomy for acute subdural hematoma
Publication date: Available online 22 November 2018Source: Journal of Clinical NeuroscienceAuthor(s): Shinya Ichimura, Kento Takahara, Masato Nakaya, Keisuke Yoshida, Yoichi Mochizuki, Masahito Fukuchi, Koji FujiiAbstractThe present study evaluated the safety and effectiveness of neuroendoscopic hematoma removal with a small craniotomy for the treatment of acute subdural hematoma (ASDH). Five patients (4 men and 1 woman) with ASDH underwent neuroendoscopic surgery with a small-size craniotomy between October 2016 and June 2018. The mean age was 87.4 years (range, 82–94). The eligibility criteria were as follows: 1)...
Source: Journal of Clinical Neuroscience - November 23, 2018 Category: Neuroscience Source Type: research

A rare cause of first seizure
Publication date: Available online 22 November 2018Source: Journal of Clinical NeuroscienceAuthor(s): Dean Jones, Dale Sebire, Lili Davies (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - November 23, 2018 Category: Neuroscience Source Type: research

Outcomes of intraparenchymal hemorrhage after direct oral anticoagulant or vitamin K antagonist therapy: A systematic review and meta-analysis
In conclusion, DOAC-IPH was not associated with increased mortality or hematoma expansion compared to VKA-IPH and may be associated with a smaller hematoma volume. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - November 23, 2018 Category: Neuroscience Source Type: research

Psychiatric symptoms in migraine patients and their attitudes towards psychological support on stigmatization
ConclusionAlthough migraine patients exhibit higher levels of psychiatric symptoms when compared to healthy individuals, it was determined that only a minority of these patients receive psychiatric treatment. Especially patients with high level of psychiatric symptoms could have sought less psychiatric help due to the concerns of stigmatization. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - November 23, 2018 Category: Neuroscience Source Type: research

Pseudomeningocele and percutaneous intrathecal lead placement complication for spinal cord stimulator
We present the first case of a spinal cord stimulator implant with a complication of symptomatic intrathecal subarachnoid lead placement with a pseudomeningocele. This complication was found with myelogram and addressed by replacement with a new spinal cord stimulator implant with paddle leads instead of percutaneous leads and obliterating the pseudomeningocele tract. Technique for epidural lead placement is discussed. This case illustrates a spinal cord stimulator implant complication of intrathecal percutaneous lead placement with pseudomeningocele and its recognition and treatment involving replacement of the system whi...
Source: Journal of Clinical Neuroscience - November 23, 2018 Category: Neuroscience Source Type: research

A novel technique for stabilization of high-grade spondylolisthesis with transvertebral fusion without reduction
Publication date: Available online 22 November 2018Source: Journal of Clinical NeuroscienceAuthor(s): Chester J. Donnally, Karthik Madhavan, Alexander J. Butler, Jonathan I. Sheu, Dustin H. Massel, Barth A. Green, Joseph P. GjolajAbstractSurgical treatment of high-grade spondylolisthesis and spondyloptosis is recommended in symptomatic patients, yet there exists much debate regarding the optimal surgical approach and the need for reduction. Similar to the Bohlman technique in that fixation is achieved across two vertebral endplates, we discuss a novel technique with the advantage of using bilateral threaded pedicle screws ...
Source: Journal of Clinical Neuroscience - November 23, 2018 Category: Neuroscience Source Type: research

Peroxisome proliferator-activated receptor-γ activation attenuates harmaline-induced cognitive impairments in rats
Publication date: Available online 22 November 2018Source: Journal of Clinical NeuroscienceAuthor(s): Iraj Aghaei, Vahid Hajali, Masoud Haghani, Zohreh Vaziri, Mahmmod Moosazadeh, Mohammad ShabaniAbstractCognitive and motor disturbances are serious concerns of the tremors induced by motor disorders. Despite the lack of effective clinical treatment, some potential therapeutic agents have been used to alleviate the cognitive symptoms in the animal models of tremor. Recent studies have shown that PPAR-γ agonists have neuroprotective effects. In the current study, the effects of pioglitazone (PIO), a peroxisome prolifera...
Source: Journal of Clinical Neuroscience - November 23, 2018 Category: Neuroscience Source Type: research

Acute necrotizing encephalopathy and a carnitine palmitoyltransferase 2 variant in an adult
We report a case of ANE in an adult with a CPT2 variant who developed spinal cord lesions. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - November 23, 2018 Category: Neuroscience Source Type: research

Outcomes of adjunctive steroid therapy in adult patients with bacterial meningitis in Taiwan: A nationwide population-based epidemiologic study
Publication date: Available online 19 November 2018Source: Journal of Clinical NeuroscienceAuthor(s): Yun-Ru Lai, Jr-Rung Lin, Wen-Neng Chang, Nai-Wen Tsai, Chih-Cheng Huang, Hung-Chen Wang, Yu-Jih Su, Wei-Che Lin, Ben-Chung Cheng, Chih-Min Su, Sheng-Yuan Hsiao, Chun-En Kuo, Cheng-Hsien LuAbstractBackgroundAlthough corticosteroids are an effective anti-inflammatory adjuvant therapy, the role of adjunctive steroid therapy in treating adult bacterial meningitis in Taiwan remains controversial.MethodsCases of acute bacterial meningitis were identified from the annual hospitalization discharge claims of the National Health Ins...
Source: Journal of Clinical Neuroscience - November 21, 2018 Category: Neuroscience Source Type: research

Positive clinical signs in neurological diseases – An observational study
Publication date: Available online 19 November 2018Source: Journal of Clinical NeuroscienceAuthor(s): Orwa Aboud, Ayman Al-Salaimeh, Sunil Kumar Raina, Kinshuk Sahaya, Archana HindujaAbstractMany patients with organic neurological disease have symptoms and signs that are unexplained by their disease condition. We attempted to explore the prevalence of positive clinical signs in patients with various organic neurological diseases.We performed a prospective uncontrolled observational study on the presence of 7 positive signs in adults with various organic neurological diseases that were admitted to our tertiary care hospital...
Source: Journal of Clinical Neuroscience - November 21, 2018 Category: Neuroscience Source Type: research

Interplays of estrogen receptor alpha gene rs2234693 with post-traumatic stress disorder influence serum glucose and lipids profiles in Chinese adolescents
Publication date: Available online 20 November 2018Source: Journal of Clinical NeuroscienceAuthor(s): Yue Feng, Jia Lin, Mi Su, Xin Zhang, Ding Zhi FangAbstractBoth post-traumatic stress disorder (PTSD) and estrogen receptor alpha (ESR1) gene rs2234693 were reported to influence serum glucose and lipids profiles. However, their interactions on serum glucose and lipids profiles have not been reported. A total of 708 Chinese Han high school students were recruited at 6th months after the 2008 Wenchuan Earthquake. Serum concentrations of fasting blood glucose (FBG), fasting blood insulin (FBI), total cholesterol (TC), triglyc...
Source: Journal of Clinical Neuroscience - November 21, 2018 Category: Neuroscience Source Type: research

Physiologic pituitary hyperplasia causing visual disturbance during adolescence
We report for the first time two cases of physiologic pituitary hyperplasia causing visual disturbance during adolescence. Case 1. A 15-year-old boy visited our department with a pituitary mass lesion on magnetic resonance imaging (MRI) associated with headache and transient bitemporal hemianopsia repeating. A visual field defect became apparent on the bitemporal upper side, and the area of the visual field defect enlarged to hemianopsia. The visual defect usually occurred in relation to exercise and continued for approximately 10 min. MRI showed the mass effect of pituitary hyperplasia to the optic chiasm. At six months...
Source: Journal of Clinical Neuroscience - November 21, 2018 Category: Neuroscience Source Type: research

Predicting the occurrence of complications following corrective cervical deformity surgery: Analysis of a prospective multicenter database using predictive analytics
Publication date: Available online 17 November 2018Source: Journal of Clinical NeuroscienceAuthor(s): Peter G. Passias, Cheongeun Oh, Samantha R. Horn, Han Jo Kim, D. Kojo Hamilton, Daniel M. Sciubba, Brian J. Neuman, Aaron J. Buckland, Gregory W. Poorman, Frank A. Segreto, Cole A. Bortz, Avery E. Brown, Themistocles S. Protopsaltis, Eric O. Klineberg, Christopher Ames, Justin S. Smith, Virginie Lafage, International Spine Study GroupAbstractWe developed a predictive model to describe risk factors for complications in cervical deformity surgeries. Cervical deformity (CD) surgical patients are growing in number, but remain ...
Source: Journal of Clinical Neuroscience - November 18, 2018 Category: Neuroscience Source Type: research

Penumbra Occlusion Device for neurovascular vessel sacrifice: Feasibility and application
ConclusionParent vessel sacrifice using a combination of PODs and standard coils appear to be a feasible, safe and effective alternative to the traditional vessel sacrifice techniques. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - November 18, 2018 Category: Neuroscience Source Type: research

Color vision testing versus pattern visual evoked potentials and optical coherence tomography parameters in subclinical optic nerve involvement in multiple sclerosis
Publication date: Available online 16 November 2018Source: Journal of Clinical NeuroscienceAuthor(s): Burcu Yuksel, Berna Dogan, Belkıs Koctekin, Nesrin Atis, Abidin Erdal, Fatma Kurtulus, Muhammet Kazim Erol, Yasemin Bicer GomceliAbstractAcute idiopathic demyelinating optic neuritis is frequently the initial manifestation of multiple sclerosis (MS). We aimed to discuss the value of color vision testing to detect possible optic nerve involvement in patients with MS who had no history of optic neuritis. We evaluated color vision with Farnsworth-Munsell 100 (FM-100) hue test. Total error scores (TES), partial error scores f...
Source: Journal of Clinical Neuroscience - November 17, 2018 Category: Neuroscience Source Type: research

Patient characteristics and critical care workflow affect paging frequency in neurocritical care
We examined the association between patient, neurocritical care workflow characteristics, and paging domains on frequency of paging using Student’s t-test, Chi-square test, and analysis of covariance. A total of 1852 patients generated 36,472 pages. The most common page tagging was “for your information” (n = 15067, 41.3%), while 2.8% (n = 1006) pages were tagged urgent. Paging was most frequent for cardiovascular (12.2%), pain, agitation, distress (6.9%) and sodium (5.3%) concerns. Paging frequency was highest for mechanically ventilated patients (p 
Source: Journal of Clinical Neuroscience - November 17, 2018 Category: Neuroscience Source Type: research

Proportion and spectrum of movement disorders in adolescent and adult patients of autoimmune encephalitis of non-neoplastic aetiology
Publication date: Available online 16 November 2018Source: Journal of Clinical NeuroscienceAuthor(s): Deepa Dash, Kavish Ihtisham, Madhavi Tripathi, Manjari TripathiAbstractWe aimed to study the proportion of patients with movement disorders in seropositive autoimmune encephalitis of non-neoplastic aetiology and also to describe the spectrum of movement disorders in them.We prospectively screened 362 patients of age>12 years with encephalitis of unknown aetiology for a panel of antibodies for autoimmune encephalitis. Demographic and clinical characteristics with focus on the movement disorders were recorded. We also e...
Source: Journal of Clinical Neuroscience - November 17, 2018 Category: Neuroscience Source Type: research

Evaluation of cognitive functions in migraineurs treated with topiramate
Publication date: Available online 16 November 2018Source: Journal of Clinical NeuroscienceAuthor(s): Bilgin Öztürk, Akçay Övünç Özön, Ömer KaradaşAbstractTopiramate for the treatment of migraine prophylaxis may cause side effects such as cognitive dysfunction. We aimed to investigate the topiramate’s efficacy in migraineours and effect on cognitive functions. 24 migraine patients (Group 1) and 24 healthy participants (Group 2) were included. In both groups event-related potentials P300 Latency, Amplitude and N200 Latency, Amplitude's were evaluated. Topiramate treatm...
Source: Journal of Clinical Neuroscience - November 17, 2018 Category: Neuroscience Source Type: research

Posterior communicating aneurysm with oculomotor nerve palsy: Predictors of nerve recovery
In conclusion, initial palsy severity and preoperative palsy times are important predictors for ONP recovery, early treatment is recommended to achieve complete recovery of ONP, regardless of the presence or absence of SAH. Prospective randomized studies should be performed to determine the influence of different therapeutic strategies (coiling vs. clipping) on nerve recovery. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - November 17, 2018 Category: Neuroscience Source Type: research

Phenotype of carnitine palmitoyltransferase II (CPT II) deficiency: A questionnaire-based survey
Publication date: Available online 16 November 2018Source: Journal of Clinical NeuroscienceAuthor(s): Pushpa Raj Joshi, Marcus Deschauer, Stephan ZierzAbstractWide spectrums of symptoms besides muscle weakness, different triggering factors and varied muscles involvement are associated with CPT II deficiency. However, systematic clinical characterization of CPT II deficiency is not known. A Questionnaire-based retrospective study on 13 biochemically and genetically confirmed CPT II deficient patients was performed to analyze these aspects. Attacks of myalgia (13/13 patients), weakness (13/13) and rhabdomyolysis (10/13 patie...
Source: Journal of Clinical Neuroscience - November 17, 2018 Category: Neuroscience Source Type: research

Feasibility of vessel wall imaging in assessing unruptured paraclinoid aneurysms: Clinical observations and preliminary experience
ConclusionsVW-MRI may be a feasible imaging technique for identifying the extradural or intradural location of unruptured paraclinoid aneurysms and may help guide management. Further larger studies may be warranted. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - November 17, 2018 Category: Neuroscience Source Type: research