The clinical characteristics of spontaneous Gram-negative bacterial meningitis in adults: A hospital-based study
Publication date: Available online 17 April 2019Source: Journal of Clinical NeuroscienceAuthor(s): Chia-Yi Lien, Jun-Jun Lee, Wan-Chen Tsai, Shih-Ying Chen, Chi-Ren Huang, Chun-Chih Chien, Cheng-Hsien Lu, Wen-Neng ChangAbstractThe epidemiologic trend of acute bacterial meningitis can change more dramatically than any other bacterial disease, and a decrease in spontaneous adult bacterial meningitis (ABM) has been noted in serial studies of the epidemiologic trend of ABM in Taiwan. The purpose of this study was to analyze the clinical characteristics, laboratory data and therapeutic outcomes of 149 patients with spontaneous ...
Source: Journal of Clinical Neuroscience - April 18, 2019 Category: Neuroscience Source Type: research

Double spinal dural arteriovenous fistula with extensive craniocaudal venous drainage
Publication date: Available online 16 April 2019Source: Journal of Clinical NeuroscienceAuthor(s): Alejandro Santillan, Jared Knopman, Athos Patsalides, Y. Pierre Gobin (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - April 18, 2019 Category: Neuroscience Source Type: research

The diagnosis of ventriculoperitoneal shunt malfunction by using phase-contrast cine magnetic resonance imaging
In this study, we utilize phase-contrast cine magnetic resonance imaging (PC cine MRI) to improve the diagnosis of VP shunt malfunction. In in vitro and in vivo experiment results demonstrate the cerebrospinal fluid (CSF) flow velocities in the shunt tube are significantly decreased in the shunt malfunction group, which indicated PC cine MRI could evaluate the CSF flow dynamics of VP shunt effectively. This method is noninvasive and simple, also can improve the diagnosis of shunt malfunction. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - April 16, 2019 Category: Neuroscience Source Type: research

Potential contribution of microRNA-125b targeting p38MAPK to relieving intermittent hypoxia-induced dementia of rat models
Publication date: Available online 15 April 2019Source: Journal of Clinical NeuroscienceAuthor(s): Haiyan Ren, Weibin Qiu, Qiuyun Lu, Chen Peng, Ying Ding, Benju Zhu, Qiang Li, Xu ChenAbstractAllowing for the correlation between intermittent hypoxia and impaired cognition, we intended to figure out whether and how dementia-relevant biomolecules (e.g. miR-125b and p38MAPK) might participate in weakening of intelligence in the context of intermittent hypoxia. Within this investigation, four groups of rat models were established, including rats treated with none, 10% continuous hypoxic (CH), 10% chronic intermittent hypoxia (...
Source: Journal of Clinical Neuroscience - April 16, 2019 Category: Neuroscience Source Type: research

Cerebral embolism and carotid-hyoid impingement syndrome
Publication date: Available online 12 April 2019Source: Journal of Clinical NeuroscienceAuthor(s): Lay Kun Kho, Timothy R Bates, Andrew Thompson, Ferry Dharsono, David PrenticeAbstractEmbolic stroke of undetermined source (ESUS) is not uncommon in young patients. Here, we describe two cases of stroke from an unusual aetiology; cerebral embolization from carotid artery injury presumed secondary to hyoid bone impingement. Both patients demonstrated angiographic evidence of hyoid bone impingement. Following resection of the greater cornu of the hyoid bone, neither patient had further strokes. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - April 13, 2019 Category: Neuroscience Source Type: research

Dynamic digital tomosynthesis-radiculography is useful for diagnosis of lumbar foraminal stenosis at an adjacent level after lumbar fusion surgery: A case report
We report a case demonstrating the visualization of nerve roots nearby metallic implants using dynamic tomosynthesis-radiculography (DTRG) after spinal fusion surgery. A 77-year-old man, who 3 years earlier underwent spine fusion surgery at L3–L5, presented complaining of newly-onset low back pain and radicular symptoms in the right fifth lumbar (L5) nerve root area. His symptoms were exacerbated when he stood upright. We suspected right L5 nerve root radiculopathy, but MRI could not depict any lesion of the nerve root because of metallic implant-related artifacts. We performed DTRG at the right L5 nerve root with ...
Source: Journal of Clinical Neuroscience - April 9, 2019 Category: Neuroscience Source Type: research

Bilateral thigh compartment syndromes from extended sitting with forward bending
Publication date: Available online 6 April 2019Source: Journal of Clinical NeuroscienceAuthor(s): Tomoyo Shimada, Taiji Tsunemi, Anri Hattori, Tomoko Nakazato-Taniguchi, Hideaki Yasuhara, Kotaro Ogaki, Nobutaka HattoriAbstractAlcohol consumption and subsequent sleeping in unusual positions often causes compression neuropathies. In this case, we experienced a unique case of bilateral leg palsy after sleeping in a forward bending position that was photographed by his colleague. We expected that prolonged blockage of the circulation of the femoral arteries resulted in bilateral thigh compartment syndromes (TCSs), leading to s...
Source: Journal of Clinical Neuroscience - April 7, 2019 Category: Neuroscience Source Type: research

Alien leg phenomenon in corticobasal syndrome
Publication date: Available online 6 April 2019Source: Journal of Clinical NeuroscienceAuthor(s): Seitaro Nohara, Hiroshi Tsuji, Akira Tamaoka (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - April 7, 2019 Category: Neuroscience Source Type: research

Pharmacoresistant seizures in neurofibromatosis type 1 related to hippocampal sclerosis: Three case presentation and review
We presented here 3 additional patients with NF1 and intractable seizures due to hippocampal sclerosis; in whom one of them underwent epilepsy surgery and he is seizure free for 5 years after right temporal lobectomy. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - April 6, 2019 Category: Neuroscience Source Type: research

Hippocampus and amygdalar volumes in patients with obsessive-compulsive personality disorder
ConclusionConsequently, our present results suggest that hippocampal and amygdalar structural abnormalities may be related to the neuroanatomy of obsessive-compulsive personality disorder. However, it is required novel studies with larger sample. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - April 6, 2019 Category: Neuroscience Source Type: research

Familial, long-term pollakisuria as initial manifestation of HSP4 due to the SPAST variant c.683-2A>C
ConclusionsPure HSP4 may manifest at onset with year-long pollakisuria exclusively. HSP4 may take a mild course over years, allowing the patient to do sports and to practice a demanding job. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - April 6, 2019 Category: Neuroscience Source Type: research

Volumetric MRI study of orbito-frontal cortex and thalamus in obsessive-compulsive personality disorder
ConclusionsWe consider that volumetric alterations determined in the present study may be involved in the pathophysiology of the OCPD, considering that OCPD might be related to OCD spectrum disorders neuroanatomically. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - April 6, 2019 Category: Neuroscience Source Type: research

Orexin secretion abnormality involved in excessive somnolence in CNS lymphoma without hypothalamic lesions
Publication date: Available online 5 April 2019Source: Journal of Clinical NeuroscienceAuthor(s): Yasuhiro Hamada, Tadayuki Takata, Rie Kawakita, Hideki Kobara, Masaki Okada, Takashi Tamiya, Takashi Kanbayashi, Tetsuo Touge, Kazushi Deguchi, Tsutomu MasakiAbstractA 72-year-old woman developed excessive somnolence as one of the symptoms of diffuse large B-cell lymphoma in the central nervous system (CNS). Although somnolence might be caused by reduced orexin secretion associated with hypothalamic lesions, neither brain MRI nor 18F-fluorodeoxyglucose positron emission tomography identified hypothalamic lesions. However, the ...
Source: Journal of Clinical Neuroscience - April 6, 2019 Category: Neuroscience Source Type: research

An alternative technique for pituitary tumour removal: Sequential endoscopic-microscopic pituitary procedure (SEMPP)
We describe our novel technique, the sequential endoscopic and microscopic pituitary procedure (SEMPP) which does not require microscopically-trained neurosurgeons to alter their technique. We compare SEMPP with the PE approach in terms of outcome and safety. Retrospective chart review of consecutive SEMPP cases performed at our institution between January 2010 and December 2013 was conducted. Operative time, gross total resection rate, resolution of endocrine and visual dysfunction, hospital length of stay, cerebrospinal fluid (CSF) leak rate and revision rates were recorded. 32 patients were identified (50% female, mean ...
Source: Journal of Clinical Neuroscience - April 5, 2019 Category: Neuroscience Source Type: research

Incremental benefits of EEG informed fMRI in the study of disorders related to meso-corticolimbic dopamine pathway dysfunction: A systematic review of recent literature
Publication date: Available online 4 April 2019Source: Journal of Clinical NeuroscienceAuthor(s): Nisha Syed Nasser, Buhari Ibrahim, Hamed Sharifat, Aida Abdul Rashid, Subapriya SuppiahAbstractFunctional magnetic resonance imaging (fMRI) is a non-invasive imaging modality that enables the assessment of neural connectivity and oxygen utility of the brain using blood oxygen level dependent (BOLD) imaging sequence. Electroencephalography (EEG), on the other hands, looks at cortical electrical impulses of the brain thus detecting brainwave patterns during rest and thought processing. The combination of these two modalities is ...
Source: Journal of Clinical Neuroscience - April 5, 2019 Category: Neuroscience Source Type: research

Fabry’s disease and stroke: Effectiveness of enzyme replacement therapy (ERT) in stroke prevention, a review with meta-analysis
ConclusionOur meta-analysis based on the currently available data showed that ERT for Fabry’s disease has beneficial effect on stroke prevention. Female carriers and atypically affected males could be started on ERT as soon as diagnosis is made. Further studies are warranted to support the role of ERT in stroke prevention. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - April 5, 2019 Category: Neuroscience Source Type: research

Distal myopathy and rapidly progressive dementia associated with a novel mutation in the VCP gene: Expanding inclusion body myopathy with early-onset Paget disease and frontotemporal dementia spectrum
We report a severe phenotype in a Portuguese patient, related to a novel mutation in the valosin-containing protein gene, characterized by a severe late-onset distal myopathy and a rapidly progressive cognitive dysfunction suggesting fronto-temporal dementia. The patient did not manifest Paget disease. Family history was negative. This case emphasizes the importance of considering inclusion body myopathy with early-onset Paget disease and fronto-temporal dementia in the differential diagnosis of distal myopathies, even in the absence of family history. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - April 5, 2019 Category: Neuroscience Source Type: research

Mirror writing after perimesencephalic subarachnoid haemorrhage
We report a case of a right-handed Caucasian woman who developed mirror writing following a non-aneurysmal, non-traumatic subarachnoid haemorrhage. The patient was unaware of having this phenomenon, and it was detected by clinical staff when the patient was writing a card to a family member. Serial imaging has ruled out a stroke as well as an underlying vascular abnormality. This phenomenon resolved after two months. Whilst there is a body of literature surrounding mirror writing, to our knowledge, this is the first description of mirror writing in the setting of a perimesencephalic subarachnoid haemorrhage. (Source: Journ...
Source: Journal of Clinical Neuroscience - April 5, 2019 Category: Neuroscience Source Type: research

A comparison of lateral ventricle volume estimation on magnetic resonance and cadaveric section images using the planimetry method
Publication date: Available online 5 April 2019Source: Journal of Clinical NeuroscienceAuthor(s): Orhan Baş, Selim Kayacı, Fatma Beyza Çeliker, Yılmaz Üçüncü, Mehmet Faik Özveren, Ali Yilmaz, Hilal Altas, Bunyamin Sahin (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - April 5, 2019 Category: Neuroscience Source Type: research

A school-aged boy with super-refractory status epilepticus secondary to cortical dysplasia treated with dexmedetomidine
Publication date: Available online 3 April 2019Source: Journal of Clinical NeuroscienceAuthor(s): John R. Malta, Jonathan Greco, Mauro Lodolo, Suman GhoshAbstractThis case report details a novel approach to the management of super-refractory status epilepticus (SRSE) in a boy with new-onset seizures progressing to SRSE. After exhausting multiple medications, dexmedetomidine, an α2-adrenoreceptor agonist used for sedation, stopped his SRSE. Dexmedetomidine provides a unique mechanism of action to treat this condition. Further studies are needed to determine its role in SRSE. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - April 4, 2019 Category: Neuroscience Source Type: research

The effect of gamma tACS over the M1 region and cerebellar hemisphere does not depend on current intensity
In this study, we aimed to clarify whether the effect of gamma tACS over M1 and the cerebellar hemisphere depends on current intensity. Twenty healthy adults performed a visuomotor control task using their right index finger for 30 s during tACS (70 Hz) over the left M1 and the right cerebellar hemisphere. Each subject participated in 10 trials, separated by intervals of 3 min. Three stimulation conditions were applied: (1) pseudo-stimulation (sham condition), (2) tACS with a current intensity of 1.0 mA and (3) tACS with a current intensity of 2.0 mA. Our results indicated that regardless of the current intensity...
Source: Journal of Clinical Neuroscience - April 4, 2019 Category: Neuroscience Source Type: research

Extensive meningeal enhancement in acute central nervous system Lyme: Case series and review of literature
Discussion. We discussed clinical implications and reviewed the relevant literature. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - April 4, 2019 Category: Neuroscience Source Type: research

Intravenous thrombolysis with tissue-plasminogen activator in small vessel occlusion
This study included 2482 patients: 193 in the IV-TPA group and 2289 in the control group. After adjusting covariates, IV-TPA treatment was associated with an increased mRS 0-1 outcome (adjusted OR [95% CI], 1.56 [1.06–2.29]; P = 0.0249), but was not significantly associated with a favorable mRS shift (1.33 [0.98–1.81]; P = 0.0709). SICH and 3-month death occurred in three (1.6%) and none in the IV-TPA group versus one (0.04%) and 16 (0.7%) in the control group. In subgroup analyses, the IV-TPA effect appeared significantly greater in patients aged ≥80 versus
Source: Journal of Clinical Neuroscience - April 4, 2019 Category: Neuroscience Source Type: research

Utility of diagnostic cerebral angiography in the management of suspected central nervous system vasculitis
In conclusion, invasive catheter-based angiography may be of limited benefit in the diagnosis and management of PCNSV when considered in the context of clinical and laboratory findings and MRA or CTA results. Further large studies are necessary to determine whether non-invasive imaging can replace DSA. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - April 4, 2019 Category: Neuroscience Source Type: research

Analysis of the prevalence and onset of dysphonia and dysphagia symptoms in movement disorders at an academic medical center
This study was conducted to determine the onset and prevalence of patient-reported dysphonia and dysphagia symptoms in Parkinson’s disease (PD), dystonia, Atypical Parkinsonian Syndromes (APS), and Essential Tremor (ET). Patients referred to a movement disorders clinic in a tertiary care academic medical center completed validated voice and swallowing specific Quality of Life (QOL) questionnaires: Voice Handicap Index-10 (VHI-10) and Eating Assessment Tool-10 (EAT-10). Patient demographics and clinical data were also collected. Two hundred and sixty-eight patients (males = 150, females = 118) completed the qu...
Source: Journal of Clinical Neuroscience - April 2, 2019 Category: Neuroscience Source Type: research

Age-related increase in GABAA receptor distribution in the prefrontal cortex
In this study, IMZ-SPECT imaging data of 21 healthy males with an age range of 22–59 (mean, 38 ± 12) years were analyzed using three-dimensional stereotactic surface projection (3D-SSP). The Z-score images of the younger group (age 
Source: Journal of Clinical Neuroscience - April 2, 2019 Category: Neuroscience Source Type: research

Unruptured brain arteriovenous malformations and hydrocephalus: Case series and review of the literature
ConclusionsThe most common cause of hydrocephalus in unruptured brain AVMs is mechanical obstruction by the draining vein if it is located in a strategic position. Treatment of hydrocephalus alone or with associated treatment of the AVM is safe and effective. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - April 2, 2019 Category: Neuroscience Source Type: research

Long-term glioblastoma survival following recovery from cytomegalovirus colitis: A case report
In this report, we present the case of a 69 year-old woman with GBM who survived seven years post-diagnosis. Following tumor resection, the patient underwent concomitant radiation and temozolomide therapy that was complicated by CMV colitis and abdominal abscesses. Despite not receiving adjuvant temozolomide, the patient demonstrated a five year progression-free survival before requiring re-resection for radiation necrosis. Following re-resection, the patient survived for two additional years. As the patient’s tumor stained positive for CMV antigens IE1 and pp65, it is hypothesized that she developed an immune resp...
Source: Journal of Clinical Neuroscience - April 2, 2019 Category: Neuroscience Source Type: research

YKL-40 can promote angiogenesis in sporadic cerebral cavernous malformation (CCM)
Publication date: Available online 1 April 2019Source: Journal of Clinical NeuroscienceAuthor(s): Yuan Shi, Yaying Song, Peixi Liu, Peiliang LiAbstractThe factors affecting the formation of sporadic CCMs remain unclear. A cDNA microarray was used to identify characteristic gene expression patterns in sporadic CCMs. Transcription level of YKL-40 was confirmed by reverse transcription-polymerase chain reaction (RT-PCR). The location and expression were revealed by immunochemistry, immunofluorescence staining and level of YKL-40 was quantified by Western blotting. Alterations to endothelial function following the up or down r...
Source: Journal of Clinical Neuroscience - April 2, 2019 Category: Neuroscience Source Type: research

Brain tissue saving effects by single-dose intralesional administration of Neuroprotectin D1 on experimental focal penetrating brain injury in rats
Publication date: Available online 1 April 2019Source: Journal of Clinical NeuroscienceAuthor(s): Rand Wilcox Vanden Berg, Johan Davidsson, Erik Lidin, Maria Angéria, Mårten Risling, Mattias GüntherAbstractTraumatic brain injury (TBI) is followed by a secondary inflammation in the brain. Neuroprotectin D1 (NPD1) is synthesized from docosahexaenoic acid (DHA) and has anti-inflammatory and antiapoptotic effects in experimental models of neurodegenerative disease and brain ischemia-reperfusion. It is not known whether intralesional administration of NPD1 ameliorates inflammation and cell death after severe T...
Source: Journal of Clinical Neuroscience - April 2, 2019 Category: Neuroscience Source Type: research

Extensive intracranial haemorrhage as a complication of acute lymphoblastic leukaemia with hyperleukocytosis
We report a rare case of distinctive extensive punctate intracranial haemorrhage associated with acute lymphoblastic leukaemia with hyperleukocytosis. A 7-year-old girl presented with hyperleukocytosis (white cell count 788.7 × 109/L; 94% peripheral blasts) and laboratory tumour lysis syndrome. The diagnosis of T-cell acute lymphoblastic leukaemia was established and confirmed by immunophenotyping of peripheral blood and chemotherapy was commenced promptly. On day 3 of treatment, she developed progressive encephalopathy, left sided hemiparesis with left 6th and upper motor neuron 7th cranial nerve palsy. Brain MR...
Source: Journal of Clinical Neuroscience - April 2, 2019 Category: Neuroscience Source Type: research

Healing of type II odontoid fracture without surgery in an octogenarian — Case report and literature review
We present the case of an 89-year-old woman presented with neck pain after a mechanical fall. She was neurologically intact. Computed tomography (CT) of the cervical spine revealed a Type II odontoid fracture with 4.4 mm of posterior displacement. Given the patient’s extensive medical comorbidities, non-operative management with a rigid cervical orthosis was elected. The patient underwent serial imaging and routine clinical follow up. CT scan at one-year follow-up demonstrated complete osseous union. The patient’s neck pain resolved and her cervical collar was discontinued. The risk benefit profile for surgic...
Source: Journal of Clinical Neuroscience - March 31, 2019 Category: Neuroscience Source Type: research

The truth about cognitive impairment in functional motor symptoms: An experimental deception study with the Guilty Knowledge Task
Publication date: Available online 30 March 2019Source: Journal of Clinical NeuroscienceAuthor(s): Benedetta Demartini, Roberta Ferrucci, Diana Goeta, Fabiana Ruggiero, Armando D'Agostino, Alberto Priori, Orsola GambiniAbstractBackgroundA century ago, Janet was the first to conceptualize conversion reactions as having a neurocognitive component, as disorders of memory processing that arise in the wake of trauma. The available evidence suggests that this impairment might arise from dysfunction in the fronto-subcortical circuits. Our aim was to examine the cognitive functions regulating deception in patients with functional ...
Source: Journal of Clinical Neuroscience - March 31, 2019 Category: Neuroscience Source Type: research

White matter lesion loads associated with dynamic functional connectivity within attention network in patients with relapsing-remitting multiple sclerosis
In conclusion, we found that the instantaneous configuration pattern of FC in attention network of RRMS are relate to lesions loads. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - March 31, 2019 Category: Neuroscience Source Type: research

Transfer times and patient outcomes – A review of head injuries requiring surgery in Tasmania 2006–2017
Publication date: Available online 29 March 2019Source: Journal of Clinical NeuroscienceAuthor(s): Nevin Colgrave, Imogen Ibbett, Nova ThaniAbstractThe Royal Hobart Hospital (RHH) provides the only neurosurgical service in the state of Tasmania, Australia, with many patients requiring surgical treatment of intracranial injuries needing to be transferred from peripheral hospitals around the state to Hobart. This retrospective review analysed the medical records of all patients who underwent a neurosurgical intervention at RHH for an intracranial injury over a 10½ year period to ascertain if prolonged transfer times c...
Source: Journal of Clinical Neuroscience - March 30, 2019 Category: Neuroscience Source Type: research

“Hearing” with electrophysiology and “seeing” with ultrasound: A useful multidimensional approach for nerve disease assessment
Publication date: Available online 29 March 2019Source: Journal of Clinical NeuroscienceAuthor(s): Daniele Coraci, Francesco C. Pagano, Claudia Loreti, Massimiliano Murgia, Luca Padua (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - March 30, 2019 Category: Neuroscience Source Type: research

Recurrent ischemic stroke in atrial fibrillation with non-vitamin K antagonist oral anticoagulation
Publication date: Available online 28 March 2019Source: Journal of Clinical NeuroscienceAuthor(s): Ho Geol Woo, Inyoung Chung, Dong Seok Gwak, Baik Kyun Kim, Beom Joon Kim, Hee-Joon Bae, Moon-Ku HanAbstractThe etiology or rate of recurrent ischemic stroke according to dosing methods including drug adherence in patients taking non-vitamin K antagonist oral anticoagulants (NOACs) remain uncertain. We investigated the association between dosing methods including drug adherence achieved with NOACs and the presence of major vessel occlusion (MVO) in patients with ischemic stroke with non-valvular atrial fibrillation (NVAF). Fro...
Source: Journal of Clinical Neuroscience - March 29, 2019 Category: Neuroscience Source Type: research

Prognostic value of elevated high-sensitivity cardiac troponin T levels in patients with acute ischemic stroke treated with endovascular thrombectomy
Publication date: Available online 28 March 2019Source: Journal of Clinical NeuroscienceAuthor(s): Yue-Zhou Cao, Lin-Bo Zhao, Sheng Liu, Qiang-Hui Liu, Lei Jiang, Chun-Gao Zhou, Zhen-Yu Jia, Wei-Zhong Zhou, Jin-Guo Xia, Wen-Tao Wu, Qing-Quan Zu, Shan-Shan Lu, Xiao-Quan Xu, Hai-Bin ShiAbstractOur objective was to assess the impact of hs-cTnT elevation on functional outcome and mortality in AIS patients with large vessel occlusion (LVO) in the anterior circulation 3 months after ET and explore factors affecting hs-cTnT elevation.A total of 143 consecutive AIS patients with large vessel occlusion (LVO) in the anterior circu...
Source: Journal of Clinical Neuroscience - March 29, 2019 Category: Neuroscience Source Type: research

Cisternal lavage via third ventriculostomy through the fenestrated lamina terminalis after aneurysm clipping: Technical note
Publication date: Available online 25 March 2019Source: Journal of Clinical NeuroscienceAuthor(s): Roland Roelz, Jürgen Grauvogel, Christian Scheiwe, Mukesch Shah, Jürgen Beck, Peter C. Reinacher, Ulrich HubbeAbstractDelayed cerebral infarction (DCI) contributes to the burden of morbidity and mortality acquired by patients with aneurysmal subarachnoid hemorrhage (SAH). Cisternal lavage may prevent DCI. Delivery of lavage therapy to the basal cisterns, however, is challenging. Here, we report a novel method for the delivery of cisternal lavage using a cisterno-ventricular catheter (CVC) inserted via the fenestrate...
Source: Journal of Clinical Neuroscience - March 26, 2019 Category: Neuroscience Source Type: research

Intradural osteogenic sarcoma in the lumbar spine
We report our workup, diagnosis, and treatment. We also include a video demonstrating the intraoperative invasion of tumor and dural erosion. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - March 26, 2019 Category: Neuroscience Source Type: research

Thermal injury to spinal cord, a rare complication of percutaneous microwave spine tumor ablation: Case report
Publication date: Available online 25 March 2019Source: Journal of Clinical NeuroscienceAuthor(s): Erick M. Westbroek, Matthew L. Goodwin, Ferdinand Hui, Majid A. Khan, Daniel M. SciubbaAbstractMetastatic disease to the spine are becoming increasingly common with an aging population and improvements in systemic cancer therapies. Surgery, radiation, and vertebroplasty are mainstay modalities for treating painful spine metastases. Recently, image-guided percutaneous ablation techniques have emerged a promising therapeutic option. Multiple studies have demonstrated the safety and efficacy of percutaneous ablation techniques; ...
Source: Journal of Clinical Neuroscience - March 26, 2019 Category: Neuroscience Source Type: research

Diffusion-weighted imaging negative M232R familial Creutzfeldt-Jakob disease
Publication date: Available online 22 March 2019Source: Journal of Clinical NeuroscienceAuthor(s): Yoon-Jung Kang, Kyung-Hye Kim, Sung-Hwan Jang, Gha-Hyun Lee, Yoon-Jung Lee, Yong-Sun Kim, Eun-Joo KimAbstractThe familial Creutzfeldt-Jakob disease (fCJD) usually has similar clinical and neuroimaging features as sporadic CJD (sCJD). A 57-year-old man presented with a four-month history of rapidly progressive dementia (RPD). Laboratory tests for RPD were all normal. Brain MRI demonstrated diffuse cortical atrophy and no abnormal cortical or striatal hyperintensities on fluid-attenuated inversion recovery (FLAIR)/diffusion wei...
Source: Journal of Clinical Neuroscience - March 23, 2019 Category: Neuroscience Source Type: research

Ischemic stroke of the “hand knob area”: A case series and literature review
In conclusion, in this series the most prevalent stroke mechanism was SUE, mainly embolic stroke of undetermined source. The outcome was excellent regardless of stroke mechanism. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - March 23, 2019 Category: Neuroscience Source Type: research

Biopsy-proven primary angiitis of the central nervous system mimicking leukodystrophy: A case report and review of the literature
We report the rare case of a 45-year-old female presenting with symptoms of intracranial hypertension and leukodystrophy-like neuroimaging findings. A comprehensive diagnostic work-up led to the unexpected diagnosis of a definite PACNS which was successfully treated by immunosuppressive treatment. Although rarely, PACNS can present as diffuse leukoencephalopathy on neuroimaging, and mimic even an inherited leukodystrophy. Therefore, in adults with leukodystrophy-like neuroimaging findings, careful examination of clinical and non-clinical features is mandatory to avoid missing the diagnosis of a treatable acquired disease. ...
Source: Journal of Clinical Neuroscience - March 23, 2019 Category: Neuroscience Source Type: research

Visual snow: Not so benign
We describe a patient who presented with visual snow, illusory visual motion, photopsia, and reduced night vision. He subsequently developed progressive cognitive impairment, myoclonus and ataxia. A diagnosis of sporadic Creutzfeldt-Jakob Disease was confirmed on post-mortem examination more than 49 months after symptom onset. The visual snow syndrome is typically benign, but our patient illustrates that occasionally it is the first manifestation of a serious brain disease. Careful application of the diagnostic criteria for the visual snow syndrome is important, particularly with the use of neuroimaging to exclude pathol...
Source: Journal of Clinical Neuroscience - March 23, 2019 Category: Neuroscience Source Type: research

Late recurrence of medulloblastoma after 17 years of complete remission
ConclusionRecurrence of medulloblastoma may occur despite more than 15 years of complete remission.Because of this fact it is mandatory to continue the follow-up of these patients.Aggressive management of recurrence is recommended in absence of disease dissemination. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - March 23, 2019 Category: Neuroscience Source Type: research

Baicalein enhances the effect of low dose Levodopa on the gait deficits and protects dopaminergic neurons in experimental Parkinsonism
In this study, we investigated the ameliorative effect of baicalein with low dose L-DOPA (25 mg/kg) on the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced Parkinsonism. The gait variability was assessed by a computer-assisted gait analysis system Catwalk. The results showed that MPTP challenged mice had significant gait deficits on dynamic paw function and posture stability. L-DOPA reversed the MPTP induced gait deficits and the effect was positively dose-dependent. The combined treatment of baicalein and under threshold dose of L-DOPA significantly improved gait functions, compared with exclusive low dose L-...
Source: Journal of Clinical Neuroscience - March 23, 2019 Category: Neuroscience Source Type: research

Extravasation control with preserved vessel patency after wire perforation during neurothrombectomy: Case report and literature review
Publication date: Available online 20 March 2019Source: Journal of Clinical NeuroscienceAuthor(s): Pouria Moshayedi, Shashvat M. Desai, Ashutosh P. JadhavAbstractParallel to a more widespread application of endovascular neurothrombectomy in acute ischemic stroke, it is critical to understand the nature and management of associated complications, including wire perforation of the middle cerebral artery (MCA). Sacrifice of the perforated vessel may be necessary to avoid fatal intra-cranial hemorrhage. Here we describe a case of right MCA distribution ischemia complicated by a right MCA perforation. Using super selective inje...
Source: Journal of Clinical Neuroscience - March 21, 2019 Category: Neuroscience Source Type: research

Vasospasm as a major complication after acute mechanical thrombectomy with stent retrievers
The objective of this retrospective study was to investigate which cases are more likely to experience vasospasm after thrombectomy with stent retrievers.MethodsWe included 29 patients diagnosed with acute cardiogenic cerebral embolism who were treated with stent retrievers at our facility from December 2014 to December 2017. Atherothrombotic brain infarction cases were excluded because it was difficult to evaluate for vasospasms. Vasospasm was defined as reversible arterial narrowing of
Source: Journal of Clinical Neuroscience - March 21, 2019 Category: Neuroscience Source Type: research

Can the trail making test black and white predict white matter hyperintensity on MRI?
Publication date: Available online 19 March 2019Source: Journal of Clinical NeuroscienceAuthor(s): Su-Hyun Han, Mi Sun Chung, SangYun Kim, Young Chul YounAbstractWhite matter hyperintensity (WMH) in the general population has clinical importance. However, MRI (magnetic resonance imaging) is not suitable for screening purposes due to high cost and restricted availability. We hypothesized that performance on the trail making test black & white (TMT-B&W) may correlate with WMH and provide a screening tool for patients with WMH. Intergroup comparisons between WMH (+) (a Fazekas score of ≥2) and WMH (−) (
Source: Journal of Clinical Neuroscience - March 20, 2019 Category: Neuroscience Source Type: research