CCR6 (CC Chemokine Receptor 6) Is Essential for the Migration of Detrimental Natural Interleukin-17-Producing {gamma}{delta} T Cells in Stroke [Basic Sciences]
Conclusions—Brain-infiltrating IL-17–producing γδ T cells belong to the subset of natural IL-17–producing γδ T cells. In stroke, these previously unrecognized innate lymphocytes trigger a highly conserved immune reaction, which is known from host responses toward pathogens. We demonstrate that therapeutic approaches targeting synergistic IL-17 and tumor necrosis factor-α pathways in parallel offer additional neuroprotection in stroke.
Source: Stroke - Category: Neurology Authors: Priyadharshini Arunachalam, Peter Ludewig, Patrick Melich, Thiruma Valavan Arumugam, Christian Gerloff, Immo Prinz, Tim Magnus, Mathias Gelderblom Tags: Animal Models of Human Disease, Basic Science Research, Inflammation, Ischemic Stroke, Neuroprotectants Original Contributions Source Type: research
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