CCR6 (CC Chemokine Receptor 6) Is Essential for the Migration of Detrimental Natural Interleukin-17-Producing {gamma}{delta} T Cells in Stroke [Basic Sciences]

Conclusions—Brain-infiltrating IL-17–producing γδ T cells belong to the subset of natural IL-17–producing γδ T cells. In stroke, these previously unrecognized innate lymphocytes trigger a highly conserved immune reaction, which is known from host responses toward pathogens. We demonstrate that therapeutic approaches targeting synergistic IL-17 and tumor necrosis factor-α pathways in parallel offer additional neuroprotection in stroke.
Source: Stroke - Category: Neurology Authors: Tags: Animal Models of Human Disease, Basic Science Research, Inflammation, Ischemic Stroke, Neuroprotectants Original Contributions Source Type: research