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Condition: Hypothermia

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Total 450 results found since Jan 2013.

Impact of Cerebral Perfusion on Outcomes of Aortic Surgery: The Society of Thoracic Surgeons Adult Cardiac Surgery Database Analysis
ConclusionsFor patients without aortic dissection and who require more than 30 minutes of circulatory arrest, optimal cerebral protection strategies are deep hypothermia with either antegrade or retrograde cerebral perfusion and moderate hypothermia with antegrade cerebral perfusion.
Source: The Annals of Thoracic Surgery - January 21, 2020 Category: Cardiovascular & Thoracic Surgery Source Type: research

Isoflurane attenuates carbogen-induced blood–brain barrier disruption independent of body temperature in mice and rats
In conclusion, isoflurane protected against BBB disruption caused by carbogen inhalation in mice and rats, but unlike isoflurane-mediated protection against ischemic BBB disruption, the effect could not be explained by anesthesia-induced hypothermia.
Source: NeuroReport - January 15, 2020 Category: Neurology Tags: Cellular, Molecular and Developmental Neuroscience Source Type: research

Differential susceptibility of human neural progenitors and neurons to ischaemic injury.
CONCLUSIONS: Highly arbourised neurons are more sensitive to ischaemic injury than NPs which did however develop marked vulnerability to prolonged injury with reoxygenation. These observations imply that therapeutic potential may be highly dependent of the developmental state of the neurons we aim to protect. PMID: 31837459 [PubMed - as supplied by publisher]
Source: Brain Research Bulletin - December 10, 2019 Category: Neurology Authors: Liu Y, Michalska AE, Dottori M, Eaton E, Courtney JM, Antonic A, Howells DW Tags: Brain Res Bull Source Type: research

Triple Neuroprotection With Targeted Hypothermia, Controlled Induced Hypertension and Barbiturate Infusion During Emergency Carotid Endarterectomy for Acute Stroke
This study aims to establish the initial safety of Triple Neuroprotection (TN) in surgical management of acute stroke.
Source: European Journal of Vascular and Endovascular Surgery - November 30, 2019 Category: Surgery Authors: Sherif Sultan, Makinderjit Dulai, John Laffey, Kevin Clarkson, Abdelaly Ma Abedi, Nora Barrett, Wael Tawfick, Niamh Hynes Source Type: research

Therapeutic hypothermia and mortality in the intensive care unit: systematic review and meta-analysis.
CONCLUSIONS: This meta-analysis suggests that after decades of extensive research, TH has yet to show a beneficial effect on mortality across different critical care diseases. PMID: 31778636 [PubMed - in process]
Source: Critical Care and Resuscitation - November 30, 2019 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

Pharmacological hypothermia induced neurovascular protection after severe stroke of transient middle cerebral artery occlusion in mice.
Abstract Therapeutic hypothermia is a potential protective strategy after stroke. The present study evaluated the neurovascular protective potential of pharmacological hypothermia induced by the neurotensin receptor 1 agonist HPI-201 after severe ischemic stroke. Adult C57BL/6 mice were subjected to filament insertion-induced occlusion of the middle cerebral artery (60 min MCAO). HPI-201 was i.p. injected 120 min after the onset of MCAO to initiate and maintain the body temperature at 32-33°C for 6 hrs. The infarct volume, cell death, integrity of the blood brain barrier (BBB) and neurovascular unit (NVU), inflam...
Source: Experimental Neurology - November 22, 2019 Category: Neurology Authors: Zhao Y, Wei ZZ, Lee JH, Gu X, Sun J, Dix TA, Wei L, Yu SP Tags: Exp Neurol Source Type: research

Mild hypothermia protects synaptic transmission from experimental ischemia through reduction in the function of nucleoside transporters in the mouse hippocampus.
Abstract Ischemia, a severe metabolic stress, increases adenosine levels and causes the suppression of synaptic transmission through adenosine A1 receptors. Although temperature also regulates extracellular adenosine levels, the effect of temperature on ischemia-induced activation of adenosine receptors is not yet fully understood. Here we examined the role of adenosine A1 receptors in mild hypothermia-mediated neuroprotection during the acute phase of ischemia. Severe ischemia-induced neurosynaptic impairment was reproduced by oxygen-glucose deprivation at normothermia (36 °C) and assessed with extracellular r...
Source: Neuropharmacology - November 13, 2019 Category: Drugs & Pharmacology Authors: Oyama Y, Ono K, Kawamura M Tags: Neuropharmacology Source Type: research

Hypothermia treatment ameliorated cyclin-dependent kinase 5-mediated inflammation in ischemic stroke and improved outcomes in ischemic stroke patients
CONCLUSIONS: Overall, hypothermia offers clinical benefit, most likely through its effects on the inflammatory response.
Source: Clinics - October 21, 2019 Category: General Medicine Source Type: research

Impact of Cerebral Perfusion on Outcomes of Aortic Surgery: STS Adult Cardiac Database Analysis
ConclusionsFor patients without dissection and requiring>30 minutes circulatory arrest, optimal cerebral protection strategies are deep hypothermia with either antegrade or retrograde cerebral perfusion; or moderate hypothermia with antegrade cerebral perfusion.
Source: The Annals of Thoracic Surgery - September 26, 2019 Category: Cardiovascular & Thoracic Surgery Source Type: research

Impact of Cerebral Perfusion on Outcomes of Aortic Surgery: STS Adult Cardiac Database Analysis.
CONCLUSIONS: For patients without dissection and requiring >30 minutes circulatory arrest, optimal cerebral protection strategies are deep hypothermia with either antegrade or retrograde cerebral perfusion; or moderate hypothermia with antegrade cerebral perfusion. PMID: 31563489 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - September 25, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Itagaki S, Chikwe J, Sun E, Chu D, Toyoda N, Egorova N Tags: Ann Thorac Surg Source Type: research

Neuroprotection by Mesenchymal Stem Cell (MSC) Administration is Enhanced by Local Cooling Infusion (LCI) in Ischemia.
CONCLUSION: Therapeutic hypothermia upregulated Miro1 and enhanced MSC mitochondrial transfer-mediated neuroprotection in ischemic stroke. Combination of LCI with MSC therapy may facilitate clinical translation of this approach. PMID: 31454517 [PubMed - as supplied by publisher]
Source: Brain Research - August 23, 2019 Category: Neurology Authors: Wei W, Wu D, Duan Y, Elkin KB, Chandra A, Guan L, Peng C, He X, Wu C, Ji X, Ding Y Tags: Brain Res Source Type: research

Neuroprotection for ischemic stroke in the endovascular era: A brief report on the future of intra-arterial therapy
Publication date: Available online 17 August 2019Source: Journal of Clinical NeuroscienceAuthor(s): Julius Griauzde, Vijay M. Ravindra, Neeraj Chaudhary, Joseph J. Gemmete, Aditya S. PandeyAbstractMechanical thrombectomy is now at the forefront of the treatment of large vessel acute ischemic stroke (AIS). Selective intra-arterial (IA) access has opened a new avenue for neuroprotection in AIS that has the potential to maximize local benefit while minimizing systemic effects. On a cellular level, neuroprotective strategies are aimed at reducing inflammation and free-radical formation, maintaining blood-brain barrier fidelity...
Source: Journal of Clinical Neuroscience - August 18, 2019 Category: Neuroscience Source Type: research

Selective endovascular cooling for stroke entails brain-derived neurotrophic factor and splenic IL-10 modulation.
Abstract Stroke poses a serious health and economic burden, and the lack of treatment options necessitates a viable therapy. Hypothermia represents a promising stroke therapy, yet side effects of full-body cooling, such as pneumonia, limit its clinical application. Selective endovascular cooling (SEC), via infusion of cold saline through the intraarterial artery, represents an attractive alternative by locally cooling the brain while preserving body temperature. However, the mechanisms underlying SEC are poorly understood. Brain-derived neurotrophic factor (BDNF) is a widely recognized promotor of neuroplasticity ...
Source: Brain Research - August 11, 2019 Category: Neurology Authors: Corey S, Abraham DI, Kaneko Y, Lee JY, Borlongan CV Tags: Brain Res Source Type: research

Cardiac Troponin I Phosphorylation Underlies Myocardial Contractile Dysfunction Induced by Hypothermia-Rewarming.
Abstract Rewarming the intact heart after a period of hypothermia is associated with reduced myocardial contractility, decreased Ca2+ sensitivity and increased cardiac troponin I (cTnI) phosphorylation. We hypothesized that hypothermia/rewarming (H/R) induces left ventricular (LV) contractile dysfunction due to phosphorylation of cTnI at Ser 23/24. To test this hypothesis, the response of wildtype mice (n=7) to H/R was compared to transgenic mice expressing slow skeletal TnI (TG-ssTnI; n=7) that lacks the Ser 23/24 phosphorylation sites. Hypothermia was induced by surface cooling and maintained at 23-25ºC for 3 h...
Source: American Journal of Physiology. Heart and Circulatory Physiology - August 1, 2019 Category: Physiology Authors: Tveita T, Arteaga GM, Han YS, Sieck GC Tags: Am J Physiol Heart Circ Physiol Source Type: research

Roles Played by the Na+/Ca2+ Exchanger and Hypothermia in the Prevention of Ischemia-Induced Carrier-Mediated Efflux of Catecholamines into the Extracellular Space: Implications for Stroke Therapy.
Abstract The release of [3H]dopamine ([3H]DA) and [3H]noradrenaline ([3H]NA) in acutely perfused rat striatal and cortical slice preparations was measured at 37 °C and 17 °C under ischemic conditions. The ischemia was simulated by the removal of oxygen and glucose from the Krebs solution. At 37 °C, resting release rates in response to ischemia were increased; in contrast, at 17 °C, resting release rates were significantly reduced, or resting release was completely prevented. The removal of extracellular Ca2+ further increased the release rates of [3H]DA and [3H]NA induced by ischemic conditions. This findi...
Source: Neurochemical Research - July 24, 2019 Category: Neuroscience Authors: Lakatos M, Baranyi M, Erőss L, Nardai S, Török TL, Sperlágh B, Vizi ES Tags: Neurochem Res Source Type: research