The undiscovered country: therapeutic targeting of carbon dioxide levels in critically ill patients.
Authors: Nichol AD PMID: 29852844 [PubMed - in process] (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - June 3, 2018 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

A wash twice a day keeps MRSA away?
Authors: Ali Abdelhamid Y PMID: 29852845 [PubMed - in process] (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - June 3, 2018 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

The search for biomarkers in the critically ill: a cautionary tale.
Authors: Moran JL, Solomon PJ Abstract The search for biomarkers has been described as a dismal patchwork of fragmented research. We review biomarkers in sepsis in the critically ill in terms of conventional single circulating proteins. Despite sepsis biomarker publications trebling over the past 6 years, currently only one, procalcitonin, has materialised promise. We survey genomic biomarker initiatives, single nucleotide polymorphisms (SNPs) and gene signatures. Despite many SNP associations with sepsis susceptibility and a limited number of genome-wide association studies, the status of these associations is tha...
Source: Critical Care and Resuscitation - June 3, 2018 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

Hypercapnia and hypercapnic acidosis in sepsis: harmful, beneficial or unclear?
Authors: Tiruvoipati R, Gupta S, Pilcher D, Bailey M Abstract Mortality related to sepsis among critically ill patients remains high. Recent literature suggests that hypercapnia may affect the pathophysiology of sepsis. The effects of hypercapnia on sepsis are largely related to the direct effect of hypercapnic acidosis on immune function and, as a consequence, of increased cardiac output that subsequently leads to improved tissue oxygenation. Appropriate management of hypercapnia may aid in improving the outcomes of sepsis. Our aim was to review the effects of compensated hypercapnia and hypercapnic acidosis on se...
Source: Critical Care and Resuscitation - June 3, 2018 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

Ventilation management in Victorian intensive care unit patients without acute respiratory distress syndrome.
CONCLUSIONS: In adults without ARDS undergoing CMV in Australian ICUs, the initial VT was a stereotypical 500 mL in one-third of participants, irrespective of sex. Moreover, around 40% of patients were exposed to an initial VT-PBW> 8.0 mL/kg. Finally, women were more likely to be exposed to a high VT and hyperventilation. PMID: 29852848 [PubMed - in process] (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - June 3, 2018 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

Impact of unit-wide chlorhexidine bathing in intensive care on bloodstream infection and drug-resistant organism acquisition.
CONCLUSIONS: In a tertiary Australian ICU, routine CHG bathing compared with triclosan did not affect the rates of ICU-acquired CLABSI or positive blood cultures. However, it significantly decreased the incidence of MRSA acquisition. PMID: 29852849 [PubMed - in process] (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - June 3, 2018 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

Sample size calculations for cluster randomised crossover trials in Australian and New Zealand intensive care research.
CONCLUSIONS: The CRXO design enables the evaluation of routinely used interventions that can bring about small, but important, improvements in patient care in the intensive care setting. PMID: 29852850 [PubMed - in process] (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - June 3, 2018 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

The comparative effects of 3% saline and 0.5M sodium lactate on cardiac function:a randomised, crossover study in volunteers.
Authors: Nalos M, Kholodniak E, Smith L, Orde S, Ting I, Slama M, Seppelt I, McLean AS, Huang S Abstract OBJECTIVE: To investigate the metabolic and cardiac effects of intravenous administration of two hypertonic solutions - 3% saline (SAL) and 0.5M sodium lactate (LAC). DESIGN, SETTING AND PARTICIPANTS: A randomised, doubleblind, crossover study in ten human volunteers. Intravenous bolus of either SAL or LAC at 3 mL/kg over 20 min followed by a 2 mL/kg infusion over 60 min. MAIN OUTCOME MEASURES: Acid base parameters and echocardiographic indices of cardiac function, cardiac output (CO), left ventricular e...
Source: Critical Care and Resuscitation - June 3, 2018 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

Fluid bolus therapy in critically ill children: a survey of practice among paediatric intensive care doctors in Australia and New Zealand.
CONCLUSIONS: Paediatric intensive care doctors prefer 0.9% saline and 4% albumin for FBT. Heart rate and blood pressure are the most preferred markers to assess fluid responsiveness. Preferences for FBT in specific conditions exist. PMID: 29852852 [PubMed - in process] (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - June 3, 2018 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

Permissive Hypercapnia, Alveolar Recruitment and Low Airway Pressure (PHARLAP): a protocol for a phase 2 trial in patients with acute respiratory distress syndrome.
This study will enrol 340 patients. The intervention group will receive daily staircase alveolar recruitment manoeuvres with incremental PEEP to a maximum of 40 cmH2O and peak pressures to a maximum of 55 cmH2O. PEEP will be titrated individually against peripheral oxygen saturation, targeting lower tidal volumes by a permissive approach to hypercapnia. In the control group, patients will receive mechanical ventilation following the ARDSNet-ARMA trial protocol, including PEEP titrated with a PEEP/fraction of inspired oxygen (FiO2) chart. Both groups will receive airway pressures ≤30 cmH2O and tidal volumes of ≤ 6 mL/...
Source: Critical Care and Resuscitation - June 3, 2018 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

Effect of active temperature management on mortality in intensive care unit patients.
Authors: Dallimore J, Ebmeier S, Thayabaran D, Bellomo R, Bernard G, Schortgen F, Saxena M, Beasley R, Weatherall M, Young P Abstract OBJECTIVE: To evaluate the effect of active temperature management on mortality, intensive care unit (ICU) and hospital length of stay, as well as the relative efficacy of antipyretic medications and physical cooling devices for achieving reductions in temperature in critically ill adults. DESIGN, SETTING AND PARTICIPANTS: Systematic review and meta-analysis of randomised controlled trials (RCTs) investigating treatments administered to febrile patients in order to reduce body te...
Source: Critical Care and Resuscitation - June 3, 2018 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

Repeated sensor use for regional cerebral oxygenation measurements by near-infrared spectroscopy: a technical report.
CONCLUSIONS: Repeated use of NIRS sensors measured StcO2 in different individuals for up to 10 days. There were no significant, systematic, persistent or progressive changes in StcO2 with extended use over time. Our findings suggest that StcO2 does not change with sensor reuse for up to 10 days. PMID: 29852855 [PubMed - in process] (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - June 3, 2018 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

The disconnect between nutrition guidelines and evidence: how much protein should I prescribe to this critically ill patient?
Authors: Deane AM, Peake SL, Chapman MJ PMID: 29458315 [PubMed - in process] (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - February 21, 2018 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

Study protocol for the Augmented versus Routine Approach to Giving Energy Trial (TARGET).
CONCLUSIONS: The results of this trial are expected to determine whether increased energy delivery, using an energy-dense formula can improve clinically meaningful outcomes, including survival. PMID: 29458316 [PubMed - in process] (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - February 21, 2018 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

Statistical analysis plan for the Augmented versus Routine Approach to Giving Energy Trial (TARGET).
CONCLUSION: We have developed a pre-specified statistical analysis plan for TARGET. To minimise analytical bias, this plan has been developed and made available to the public domain before completing recruitment and data collection. PMID: 29458317 [PubMed - in process] (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - February 21, 2018 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

Protocol summary and statistical analysis plan for the intensive care unit randomised trial comparing two approaches to oxygen therapy (ICU-ROX).
CONCLUSIONS: ICU-ROX will compare the effect of conservative v standard oxygen therapy in critically ill mechanically ventilated adults who are expected to be ventilated beyond the day after recruitment on ventilatorfree days to Day 28. TRIAL REGISTRATION: Australian and New Zealand Clinical Trials Registry (ANZCTRN 12615000957594). PMID: 29458318 [PubMed - in process] (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - February 21, 2018 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

Proportional assist ventilation versus pressure support ventilation in weaning ventilation: a pilot randomised controlled trial.
CONCLUSIONS: Both modes of ventilation were comparable in time to liberation from the ventilator. PMID: 29458319 [PubMed - in process] (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - February 21, 2018 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

Evaluation of urea and creatinine change during continuous renal replacement therapy: effect of blood flow rate.
CONCLUSIONS: Faster BFR did not affect solute control in patients receiving CRRT; however, differences in urea and creatinine concentrations were influenced by serum haemoglobin and hours of treatment. PMID: 29458320 [PubMed - in process] (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - February 21, 2018 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

Differential effects of isotonic and hypotonic 4% albumin solution on intracranial pressure and renal perfusion and function.
Authors: Iguchi N, Kosaka J, Bertolini J, May CN, Lankadeva YR, Bellomo R Abstract OBJECTIVES: Albumin is used to resuscitate trauma patients but may increase intracranial pressure (ICP). Its effects on renal blood flow and function are unknown. Our aim was to examine the effects of hypertonic albumin on ICP and renal function, and if any effects are due to the hypotonicity of the solution containing albumin or to albumin itself. DESIGN, SETTING AND SUBJECTS: Cross-over, randomised controlled experimental study of six adult Merino ewes in the animal facility of a research institute. METHOD: Sheep were impla...
Source: Critical Care and Resuscitation - February 21, 2018 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

Predicting recovery from acute kidney injury in critically ill patients: development and validation of a prediction model.
CONCLUSION: We constructed and validated a simple model that can predict the chance of recovery from AKI in critically ill patients. PMID: 29458322 [PubMed - in process] (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - February 21, 2018 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

A randomised controlled trial to determine the effectiveness of a radial arterial catheter dressing.
Authors: Healy C, Baldwin I, Currey J, Driscoll A Abstract OBJECTIVE: To reduce radial arterial catheter failure in patients admitted to an adult intensive care unit (ICU). DESIGN: A randomised controlled trial. SETTING: A single site, large metropolitan tertiary referral public hospital. PARTICIPANTS: Three hundred participants admitted to an adult ICU were enrolled between 25 May and 13 September 2015. INTERVENTIONS: Participants were randomly assigned to one of two treatment groups (a polyurethane adhesive keyhole dressing or a polyurethane adhesive keyhole dressing together with a polyurethane s...
Source: Critical Care and Resuscitation - February 21, 2018 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

Smoking cessation therapy in Australian and New Zealand intensive care units: a multicentre point prevalence study.
CONCLUSIONS: The prevalence of smoking in Australian and New Zealand ICUs patients is high. Over half of participating ICUs reported the routine prescription of NRT despite uncertainty regarding the practice. Further research evaluating the safety and efficacy of NRT is required. PMID: 29458324 [PubMed - in process] (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - February 21, 2018 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

Comparison of continuous-wave Doppler ultrasound monitor and echocardiography to assess cardiac output in intensive care patients.
Authors: Smith BE, Madigan VM PMID: 29458325 [PubMed - in process] (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - February 21, 2018 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

Pharmacodynamics of intravenous frusemide bolus in critically ill patients.
Authors: Cioccari L, Bellomo R PMID: 29297629 [PubMed - in process] (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - January 5, 2018 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

Determining the optimum capacity to train: a challenge for the College of Intensive Care Medicine of Australia and New Zealand.
Authors: Ashbolt M, Corke C, Venkatesh B PMID: 29202251 [PubMed - in process] (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - December 6, 2017 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

The case for more pilot studies.
Authors: Luethi N, Udy A PMID: 29202252 [PubMed - in process] (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - December 6, 2017 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

The evolution of intensive care medicine: a personal journey.
Authors: Myburgh J PMID: 29202253 [PubMed - in process] (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - December 6, 2017 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

Incidence, correlates and outcomes associated with falls in the intensive care unit: a retrospective cohort study.
Authors: Trumble D, Meier MA, Doody M, Wang X, Bagshaw SM Abstract BACKGROUND: Falls among hospitalised patients contribute to avoidable morbidity and prolonged hospital stay. We aimed to describe the incidence, circumstances and outcomes associated with patient falls occurring in intensive care units. METHODS: Retrospective cohort study of adult admissions to an academic, tertiary ICU in Edmonton, Canada between 1 January 2013 and 30 April 2016. Fall events were ascertained by interrogation of an electronic health record. Each fall was independently adjudicated by two intensivists to confirm that a fall did oc...
Source: Critical Care and Resuscitation - December 6, 2017 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

Patterns of organ donation in children in Australia and New Zealand.
Authors: Corkery-Lavender T, Millar J, Cavazzoni E, Gelbart B Abstract OBJECTIVES: Paediatric organ donation (OD) represents a small proportion of total OD in Australia and New Zealand. Our aim was to describe the patterns of paediatric OD, specifically, the demographic characteristics and donation outcomes over two time periods. DESIGN: We performed a retrospective study using national OD and intensive care registry data from intensive care units in Australia and New Zealand from 1 January 2000 to 31 December 2015. Data were analysed between two time periods. Paediatric data were compared with adult data. ...
Source: Critical Care and Resuscitation - December 6, 2017 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

Long-term mortality of critically ill patients with diabetes who survive admission to the intensive care unit.
Authors: Ali Abdelhamid Y, Plummer MP, Finnis ME, Biradar V, Bihari S, Kar P, Moodie S, Horowitz M, Shaw JE, Phillips LK, Deane AM Abstract OBJECTIVE: Long-term outcomes of critically ill patients with diabetes are unknown. Our objectives were to evaluate the effect of diabetes on both long-term survival rates and the average number of years of life lost for patients admitted to an intensive care unit who survived to hospital discharge. DESIGN AND PARTICIPANTS: A data linkage study evaluating all adult patients in South Australia between 2004 and 2011 who survived hospitalisation that required admission to a pu...
Source: Critical Care and Resuscitation - December 6, 2017 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

Maintenance fluid practices in paediatric intensive care units in Australia and New Zealand.
Authors: Bihari S, Gelbart B, Seppelt I, Thompson K, Watts N, Prakash S, Festa M, Bersten A, The George Institute for Global Health , The Australian and New Zealand Intensive Care Society Clinical Trials Group Abstract BACKGROUND: Maintenance fluid administration is a common practice in paediatric intensive care units (PICUs), contributing to daily fluid intake and fluid balance, but little is known about this practice. OBJECTIVES: To determine the volume and type of maintenance fluid delivered to PICU patients, and to assess changes in practice compared with a previous time point. METHODS: A prospective...
Source: Critical Care and Resuscitation - December 6, 2017 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

The SPICE III study protocol and analysis plan: a randomised trial of early goaldirected sedation compared with standard care in mechanically ventilated patients.
CONCLUSION: SPICE III is an ongoing large scale clinical trial. Once completed, it will inform sedation practice in critically ill patients who are ventilated. PMID: 29202258 [PubMed - in process] (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - December 6, 2017 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

Bedside lung ultrasound in the care of the critically ill.
Authors: Rudas M, Orde S, Nalos M Abstract OBJECTIVE: To describe the technique and review the utility of bedside lung ultrasound in acute care. SUMMARY: Lung ultrasound is a useful point-of-care investigation in acute care, especially in patients with dyspnoea or haemodynamic instability. Although normal lung parenchyma is not accessible to ultrasound, distinctive artefacts arising from parietal and visceral pleura indirectly imply the presence of normal lung. As aeration of lung tissue reduces with disease process, visual assessment of several pathologic entities by ultrasound becomes possible. Ultrasound can...
Source: Critical Care and Resuscitation - December 6, 2017 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

Interobserver agreement for post mortem renal histopathology and diagnosis of acute tubular necrosis in critically ill patients.
Authors: Glassford NJ, Skene A, Guardiola MB, Chan MJ, Bagshaw SM, Bellomo R, Solez K Abstract BACKGROUND: The renal histopathology of critically ill patients dying with acute kidney injury (AKI) in intensive care units of high income countries remains uncertain. METHODS: Retrospective observational assessment of interobserver agreement in the reporting of renal post mortem histopathology, and the ability of pathologists blinded to the clinical context to independently identify the presence of pre-mortem AKI from digital images of histological sections from 34 critically ill patients dying in teaching hospitals...
Source: Critical Care and Resuscitation - December 6, 2017 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

Intensive care unit randomised trial comparing two approaches to oxygen therapy (ICU-ROX): results of the pilot phase.
The objective of the intensive care unit randomised trial comparing two approaches to oxygen therapy (ICU-ROX) pilot phase, which included the first 100 patients of an overall sample of 1000, was to examine feasibility. DESIGN: Investigator-initiated, prospective, parallel-group, pilot randomised controlled trial. SETTING: Six medical-surgical intensive care units (ICUs) in Australia and New Zealand, with participants recruited from September 2015 through June 2016. PARTICIPANTS: 100 patients ≥ 18 years of age who required invasive mechanical ventilation in the ICU and were expected to be receiving it beyond...
Source: Critical Care and Resuscitation - December 6, 2017 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

Pharmacodynamics of intravenous frusemide bolus in critically ill patients.
Authors: Shann F PMID: 29202262 [PubMed - in process] (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - December 6, 2017 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

Rise of the machines - the growing influence of the Asia-Pacific in the world of mechanical support.
Authors: Fraser JF, Bellomo R PMID: 29084494 [PubMed - in process] (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - November 2, 2017 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

Appraising extracorporeal life support - current and future roles in adult intensive care.
Authors: Shekar K, Brodie D, Fraser J, MacLaren G PMID: 29084495 [PubMed - in process] (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - November 2, 2017 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

Incremental research approach to describing the pharmacokinetics of ciprofloxacin during extracorporeal membrane oxygenation.
CONCLUSIONS: We provide preliminary evidence that ciprofloxacin dosing in ECMO patients should remain in line with the recommended dosing strategies for critically ill patients not receiving ECMO. PMID: 29084496 [PubMed - in process] (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - November 2, 2017 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

Extracorporeal membrane oxygenation in adult congenital heart disease: a case series and literature review.
CONCLUSION: ECMO is a promising temporary rescue intervention for patients with ACHD and cardiogenic shock. The extracorporeal cardiac support is a useful bridge to recovery. PMID: 29084497 [PubMed - in process] (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - November 2, 2017 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

To be or not to be on ECMO: can survival prediction models solve the question?
Authors: Rozencwajg S, Fraser J, Montero S, Combes A, Schmidt M Abstract Over the past decade, there has been growing interest in extracorporeal membrane oxygenation (ECMO) as a rescue therapy for patients with severe acute respiratory distress syndrome (ARDS) and cardiogenic shock. Although survival of ECMO-treated patients has improved recently, the incidence of ECMO-related complications such as bleeding and nosocomial infections remains unacceptably high. In addition, patients often experience long-term physiological and psychological sequelae. Hence, identifying patients who will most likely benefit from ECMO ...
Source: Critical Care and Resuscitation - November 2, 2017 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

A pilot, randomised controlled trial of a rotational thromboelastometry-based algorithm to treat bleeding episodes in extracorporeal life support: the TEM Protocol in ECLS Study (TEMPEST).
Authors: Buscher H, Zhang D, Nair P Abstract OBJECTIVES: Minimal evidence to guide haemostatic therapy for bleeding in extracorporeal life support (ECLS) has resulted in wide variability in practice. We aimed to show that a goal-directed algorithm incorporating results from thromboelastometry (TEM) is feasible and safe for the timely management of bleeding episodes in adult patients receiving ECLS. DESIGN AND PARTICIPANTS: A pilot randomised controlled trial involving 16 adult patients who underwent ECLS, randomised over 10 months. INTERVENTION: The intervention group was treated according to a goal-directe...
Source: Critical Care and Resuscitation - November 2, 2017 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

The impact of venovenous extracorporeal membrane oxygenation on cytokine levels in patients with severe acute respiratory distress syndrome: a prospective, observational study.
CONCLUSION: Cytokine levels, on average, fall rapidly after initiation of VV ECMO, which may be related to the reduction of invasiveness of mechanical ventilation. Higher cytokine levels are associated with extrapulmonary causes of ARDS, more aggressive mechanical ventilation before VV ECMO, and mortality. PMID: 29084500 [PubMed - in process] (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - November 2, 2017 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

Acquired von Willebrand syndrome in respiratory extracorporeal life support: a systematic review of the literature.
CONCLUSION: The prevalence of AvWF among patients on VV ECMO or ECCO2R is high, but only a limited number of studies are reported in the literature. AvWS testing should be performed, including vWF multimer analysis, vWF activity and vWF antigen concentration. The extent to which vWF contributes to bleeding during ECMO, or how much changes in ECMO management can influence high molecular weight vWF multimer levels, cannot be answered from the currently available evidence and there remains a need for future studies. PMID: 29084501 [PubMed - in process] (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - November 2, 2017 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

In-hospital outcome of post-cardiotomy extracorporeal life support in adult patients: the 2007-2017 Maastricht experience.
CONCLUSIONS: Our experience confirms an increased use of PC-ECLS during the last 10 years and shows that, by carefully addressing patient management and complications, survival rat e may be satisfactory, and improved outcome may be achieved in such a challenging ECLS setting. PMID: 29084502 [PubMed - in process] (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - November 2, 2017 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

The evolving role and practical application of extracorporeal carbon dioxide removal in critical care.
Authors: Barrett NA, Camporota L Abstract OBJECTIVE: Extracorporeal venovenous carbon dioxide removal (ECCO2R) is increasingly used to facilitate ultraprotective mechanical ventilation, or to prevent or avoid mechanical ventilation in selected patients. This review focuses on how extracorporeal devices clear CO2, their impact on native pulmonary physiology, and systemic gas exchange. Finally, we discuss the modifications to patient management required while on ECCO2R. PMID: 29084503 [PubMed - in process] (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - November 2, 2017 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

Nosocomial infections acquired by patients treated with extracorporeal membrane oxygenation.
CONCLUSIONS: Infectious complications are common in ECMO patients and are associated with longer durations of hospital admission. Isolated pathogens were predominantly hospital-acquired Gram-negative bacteria and yeasts. Immunosuppression and treatment with VA ECMO were found to be specific risk factors for infection. PMID: 29084504 [PubMed - in process] (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - November 2, 2017 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

Management strategies in venovenous extracorporeal membrane oxygenation: a retrospective comparison from five European centres.
CONCLUSION: There is great diversity in management modalities for ventilator and ECMO settings for patients with bacterial pneumonia. Our study emphasises the lack of clinical consensus in VV ECMO management. PMID: 29084505 [PubMed - in process] (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - November 2, 2017 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

Glycaemic control in diabetic ketoacidosis: Too much of a good thing?
Authors: McArthur C PMID: 28866968 [PubMed - in process] (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - September 6, 2017 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

A scoping review of use of wearable devices to evaluate outcomes in survivors of critical illness.
Authors: Gluck S, Chapple LS, Chapman MJ, Iwashyna TJ, Deane AM Abstract OBJECTIVE: Wearable devices using new technology may be a cost-effective method to assess functional outcomes in survivors of critical illness. Our primary objective was to review the extent to which wearable devices such as smartphones, pedometers, accelerometers and global positioning systems have been used to evaluate outcomes in survivors of an intensive care unit admission. DESIGN: We included studies of patients surviving an ICU admission and which measured outcomes using wearable devices. We performed a scoping review of studies fou...
Source: Critical Care and Resuscitation - September 6, 2017 Category: Intensive Care Tags: Crit Care Resusc Source Type: research