Can the combination of internal iliac temporary occlusion and uterine artery embolization reduce bleeding and the need for intraoperative blood transfusion in cases of invasive placentation?
CONCLUSION: The combination of temporary balloon occlusion and uterine artery embolization does not seem to promote better hemorrhage control than each procedure performed individually does. (Source: Clinics)
Source: Clinics - June 20, 2019 Category: General Medicine Source Type: research

Cardiovascular risk in children and adolescents with end stage renal disease
CONCLUSION: Children exhibited important cardiovascular involvement at the time of the renal transplantation. Both of the studied outcomes were independently associated with systolic blood pressure. For this reason, controlling blood pressure seems to be the main therapy to minimize cardiovascular involvement in children with ESRD. (Source: Clinics)
Source: Clinics - June 20, 2019 Category: General Medicine Source Type: research

Metabolic and hormonal assessment of adolescent and young adult women with prior premature adrenarche
CONCLUSION: The percentage of patients with polycystic ovary syndrome who also had overweight, obesity and insulin resistance corroborates the literature data about the need for follow-up aiming at interventions, especially for conditions associated with cardiometabolic risk. (Source: Clinics)
Source: Clinics - June 20, 2019 Category: General Medicine Source Type: research

The evaluation of the Myxovirus Resistance 1 protein in serum and saliva to monitor disease activation in primary Sj√∂gren’s syndrome
OBJECTIVE: Primary Sj ögren ’ s syndrome (pSjS) is a chronic autoimmune disease that causes dry eye and mouth. No laboratory parameters to monitor the activation of this disease have been identified. Therefore, any possible relationships between salivary and blood myxovirus resistance 1 (MX1) and pSjS must be prospectively studied. METHODS: Thirty female patients with pSjS, 30 women with rheumatoid arthritis (RA) without secondary Sj ögren ’ s syndrome (SjS) and 28 healthy control women were enrolled in this investigation. Analyses of MX1 by the enzyme-linked immunosorbent assay (ELISA) method, SS-A (...
Source: Clinics - June 20, 2019 Category: General Medicine Source Type: research

Hypertonic saline and pentoxifylline enhance survival, reducing apoptosis and oxidative stress in a rat model of strangulated closed loop small bowel obstruction
OBJECTIVES: Intestinal obstruction has a high mortality rate when therapeutic treatment is delayed. Resuscitation in intestinal obstruction requires a large volume of fluid, and fluid combinations have been studied. Therefore, we evaluated the effects of hypertonic saline solution (HS) with pentoxifylline (PTX) on apoptosis, oxidative stress and survival rate. METHODS: Wistar rats were subjected to intestinal obstruction and ischemia through a closed loop ligation of the terminal ileum and its vessels. After 24 hours, the necrotic bowel segment was resected, and the animals were randomized into four groups according to the...
Source: Clinics - June 7, 2019 Category: General Medicine Source Type: research

Screening of Strongyloides infection using an ELISA test in transplant candidates
CONCLUSIONS: The present results suggest the ELISA test, ideally using soluble fractions of filariform larvae S. venezuelensis in PBS, as an additional strategy for the diagnosis of strongyloidiasis in transplant candidates. (Source: Clinics)
Source: Clinics - June 7, 2019 Category: General Medicine Source Type: research

Clinical evaluation of a bone cement-injectable cannulated pedicle screw augmented with polymethylmethacrylate: 128 osteoporotic patients with 42 months of follow-up
This study included 128 patients with osteoporosis (BMD T-score − 3.2 ±1.9; range, − 5.4 to -2.5) who underwent spinal decompression and instrumentation with a polymethylmethacrylate-augmented bone cement-injectable cannulated pedicle screw. Postoperative Visual Analogue Scale scores and the Oswestry Disability Index were compared with preoperative values. Postoperative plain radiographs and computed tomography (CT) scans were performed immediately after surgery; at 1, 3, 6, and 12 months; and annually thereafter. RESULTS: The mean follow-up time was 42.4 ±13.4 months (range, 23 to 71 months). A t...
Source: Clinics - June 7, 2019 Category: General Medicine Source Type: research

Sexuality, depression and body image after breast reconstruction
CONCLUSION: Patients who had undergone breast reconstruction after mastectomy reported better sexual function and body image and fewer depressive symptoms than patients who had undergone mastectomy alone. Sexual dysfunction was associated with the absence of a marital partner and a higher level of education and was more frequent in the mastectomy group. (Source: Clinics)
Source: Clinics - May 31, 2019 Category: General Medicine Source Type: research

Pancreatic endosonographic findings and clinical correlation in Crohn's disease
OBJECTIVES: We aimed to evaluate the incidence of pancreatic alterations in Crohn's disease using endoscopic ultrasound (EUS) and to correlate the number of alterations with current clinical data. METHODS: Patients diagnosed with Crohn's disease (n=51) were examined using EUS, and 11 variables were analyzed. A control group consisted of patients with no history of pancreatic disease or Crohn's disease. Patients presenting with three or more alterations underwent magnetic resonance imaging (MRI). Pancreatic function was determined using a fecal elastase assay. RESULTS: Two of the 51 patients (3.9%) presented with four EUS a...
Source: Clinics - May 31, 2019 Category: General Medicine Source Type: research

Mandibular radiomorphometric assessment of bone mineral density in survivors of pediatric hematopoietic stem-cell transplantation
CONCLUSIONS: HSCT childhood survivors exhibit quantitative and qualitative mandibular bone impairments. Further studies are needed to establish an association between mandibular cortical bone impairment and osteoporosis. (Source: Clinics)
Source: Clinics - May 31, 2019 Category: General Medicine Source Type: research

Clinical comparison between a percutaneous hydraulic pressure delivery system and balloon tamp system using high-viscosity cement for the treatment of osteoporotic vertebral compression fractures
CONCLUSIONS: The percutaneous HPDS with high-viscosity cement has similar clinical outcomes to those of traditional procedures in the treatment of vertebral fractures in the elderly. The HPDS with high-viscosity cement is better than the BTS in the treatment of mild and moderate OVCFs and could be an alternative method for the treatment of severe OVCFs. (Source: Clinics)
Source: Clinics - May 31, 2019 Category: General Medicine Source Type: research

ERRATA: The effectiveness of current informative material in improving awareness and opinion of undergraduate students towards organ donation: a comparative, randomized survey study
This article is the first to systematically evaluate this relationship. A comprehensive worldwide search was conducted for relevant literature on surfactant-associated protein D gene mutations and chronic obstructive pulmonary disease risk prediction. Study quality was evaluated using the Newcastle-Ottawa scale. After four genetic models (the allele, additive, recessive, and dominant models) were identified, odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were applied in this meta-analysis. The meta-analysis included 659 individuals in the case group and 597 in the control group. In the Asian populat...
Source: Clinics - May 17, 2019 Category: General Medicine Source Type: research

Association of Surfactant-Associated Protein D Gene Polymorphisms with the Risk of COPD: a Meta-Analysis
This article is the first to systematically evaluate this relationship. A comprehensive worldwide search was conducted for relevant literature on surfactant-associated protein D gene mutations and chronic obstructive pulmonary disease risk prediction. Study quality was evaluated using the Newcastle-Ottawa scale. After four genetic models (the allele, additive, recessive, and dominant models) were identified, odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were applied in this meta-analysis. The meta-analysis included 659 individuals in the case group and 597 in the control group. In the Asian populat...
Source: Clinics - May 17, 2019 Category: General Medicine Source Type: research

Transplants in Brazil: where are we?
(Source: Clinics)
Source: Clinics - May 17, 2019 Category: General Medicine Source Type: research

Incidence and mortality of bone cancer among children, adolescents and young adults of Brazil
CONCLUSION: Osteosarcoma and Ewing Sarcoma are the most incident bone cancers in all Brazilian regions. Bone cancers showed incidence and mortality patterns variation within the geographic regions and across age groups, although not significant. Despite limitations, it is crucial to monitor cancer epidemiology trends across geographic Brazilian regions. (Source: Clinics)
Source: Clinics - May 14, 2019 Category: General Medicine Source Type: research

Generating evidence and understanding the treatment of osteoarthritis in Brazil: a study through Delphi methodology
CONCLUSION: The committee pointed to the need for early intervention and that the available medicinal resources can fulfil this important role, as is the case with SYSADOA treatments. Glucosamine-based medicinal products with or without chondroitin could also fulfill this need for early treatment. The other generated evidence and included investigations were then grouped together and are the subject of this publication. (Source: Clinics)
Source: Clinics - May 14, 2019 Category: General Medicine Source Type: research

The myofascial component of the pain in the painful shoulder of the hemiplegic patient
OBJECTIVES: Poststroke shoulder pain occurs very frequently and compromises function and quality of life. Because treatment depends on a multidisciplinary approach, it is desirable to optimize effectiveness. Myofascial pain syndrome is defined by the presence of trigger points that can also be found in spastic stroke patients. The aim of this study was to evaluate the frequency of myofascial pain in the shoulder girdle muscles in patients with poststroke shoulder pain and to document the clinical and functional results obtained with specific treatment for this condition. METHODS: Spastic stroke hemiplegic patients undergoi...
Source: Clinics - April 30, 2019 Category: General Medicine Source Type: research

Swimming training potentiates the recovery of femoral neck strength in young diabetic rats under insulin therapy
CONCLUSIONS: Eight weeks of swimming training potentiates the recovery of femoral neck strength in young rats with severe streptozotocin-induced diabetes under insulin therapy. (Source: Clinics)
Source: Clinics - April 30, 2019 Category: General Medicine Source Type: research

Efficacy and safety of sitagliptin added to metformin and insulin compared with voglibose in patients with newly diagnosed type 2 diabetes
CONCLUSIONS: Sitagliptin added to combined metformin and insulin therapy showed greater efficacy and good safety regarding hypoglycemia in patients with newly diagnosed T2DM compared with voglibose. (Source: Clinics)
Source: Clinics - April 30, 2019 Category: General Medicine Source Type: research

Authors’ Reply – Comments: Influence of the prone position on a stretcher for pregnant women on maternal and fetal hemodynamic parameters and comfort in pregnancy
The very large economic and social burdens of fracture-related complications make rapid fracture healing a major public health goal. The role of parathyroid hormone (PTH) in treating osteoporosis is generally accepted, but the effect of PTH on fracture healing is controversial. This meta-analysis was designed to investigate the efficacy and safety of PTH in fracture healing. The EMBASE, PubMed, and Cochrane Library databases were systematically searched from the inception dates to April 26, 2018. The primary randomized clinical trials comparing PTH treatment for fracture healing with placebo or no treatment were identified...
Source: Clinics - April 26, 2019 Category: General Medicine Source Type: research

The effectiveness and safety of parathyroid hormone in fracture healing: A meta-analysis
The very large economic and social burdens of fracture-related complications make rapid fracture healing a major public health goal. The role of parathyroid hormone (PTH) in treating osteoporosis is generally accepted, but the effect of PTH on fracture healing is controversial. This meta-analysis was designed to investigate the efficacy and safety of PTH in fracture healing. The EMBASE, PubMed, and Cochrane Library databases were systematically searched from the inception dates to April 26, 2018. The primary randomized clinical trials comparing PTH treatment for fracture healing with placebo or no treatment were identified...
Source: Clinics - April 26, 2019 Category: General Medicine Source Type: research

The effectiveness of current informative material in improving awareness and opinion of undergraduate students towards organ donation: a comparative, randomized survey study
This study aimed to assess the effect of informative material about organ donation on changes in the trend of answers to a questionnaire compared to the answers of a control group. METHODS: Two randomized groups were compared, receiving the same standardized questionnaire. One group was supplied informative material on the subject, while the other was not. The questionnaire was sent to undergraduate students from two Brazilian universities. Statistical analysis was performed using Student ’ s t-test, Chi-square test and multinomial regression tests. Adopted significance was 5%. RESULTS: There were 739 responses to th...
Source: Clinics - April 26, 2019 Category: General Medicine Source Type: research

Osteosarcoma of the jaw – experience at the Medical University Vienna and comparative study with international tumor registries
CONCLUSIONS: Uncertainties about the optimal treatment strategies of OSAJ patients will currently remain. Thus, prospective studies of OSAJ are needed but are only feasible in a multicenter study setting, conducted over a prolonged time period. (Source: Clinics)
Source: Clinics - April 26, 2019 Category: General Medicine Source Type: research

Evaluation of the use of blood in surgeries as a tool to change patterns for requesting blood product reserves
CONCLUSION: The RTP and C/T ratios can guide RBC requests in the preoperative period. Knowing the standard of use of blood products and developing protocols enables the optimization of reserves, reduction of costs and improvement of care. (Source: Clinics)
Source: Clinics - April 26, 2019 Category: General Medicine Source Type: research

7.0T ultrahigh-field MRI directly visualized the pedunculopontine nucleus in Parkinson’s disease patients
CONCLUSION: Our findings provide, for the first time, direct visualization of the PPN using the MP2RAGE sequence on a 7.0T ultrahigh-field MRI, which may improve the accuracy of stereotactic targeting of the PPN and improve the outcomes in patients undergoing DBS. (Source: Clinics)
Source: Clinics - April 15, 2019 Category: General Medicine Source Type: research

Development and evaluation of a training model for paracentetic suprapubic cystostomy and catheterization
CONCLUSIONS: Based on its cost-effectiveness, reusability, and training effectiveness, this paracentetic suprapubic cystostomy training model is able to achieve goals in teaching practice quickly and easily. Use of the model should be encouraged for training senior medical students and resident physicians who may be expected to perform emergent suprapubic catheter insertion at some time. (Source: Clinics)
Source: Clinics - April 15, 2019 Category: General Medicine Source Type: research

Comments: Influence of the prone position on a stretcher for pregnant women on maternal and fetal hemodynamic parameters and comfort in pregnancy
Basilar invagination (BI) and Chiari malformation type I (CM-I) are very important anomalies that introduce instability and compression in the occipitocervical transition region and have complex clinical characteristics. These anomalies vary according to the affected structures. The present study revises current knowledge regarding the anatomy, anatomo-physiology, clinical manifestations, and radiological findings of these entities and the associated surgical treatment approaches. A bibliographic survey was performed through a search in the Medline, PubMed, SciELO, Science and LILACS databases. When associated, these crani...
Source: Clinics - April 9, 2019 Category: General Medicine Source Type: research

Basilar invagination associated with chiari malformation type I: A literature review
Basilar invagination (BI) and Chiari malformation type I (CM-I) are very important anomalies that introduce instability and compression in the occipitocervical transition region and have complex clinical characteristics. These anomalies vary according to the affected structures. The present study revises current knowledge regarding the anatomy, anatomo-physiology, clinical manifestations, and radiological findings of these entities and the associated surgical treatment approaches. A bibliographic survey was performed through a search in the Medline, PubMed, SciELO, Science and LILACS databases. When associated, these crani...
Source: Clinics - April 9, 2019 Category: General Medicine Source Type: research

Diagnostic value of pediatric blood culture bottles for acute postoperative endophthalmitis
CONCLUSION: PBCBs can be used successfully in clinically suspected endophthalmitis. The method showed a higher yield of positive cultures than the conventional method. This technique appears to have several advantages over the traditional method: it saves time, as only one medium needs to be inoculated; transportation to a laboratory is easier than in the traditional method, and there is no need to maintain a supply of fresh agar media. The use of PBCBs may be recommended as the primary method for microbiological diagnosis and is especially suitable for office settings and remote clinics. (Source: Clinics)
Source: Clinics - April 9, 2019 Category: General Medicine Source Type: research

Ultrasound of entheses in ankylosing spondylitis patients: The importance of the calcaneal and quadriceps entheses for differentiating patients from healthy individuals
CONCLUSION: US analysis showed that only entheses of the foot and quadriceps were able to differentiate AS patients from healthy individuals. (Source: Clinics)
Source: Clinics - April 9, 2019 Category: General Medicine Source Type: research

Effects of a dietary supplement on inflammatory marker expression in middle-aged and elderly hypertensive patients
This study lasted for six weeks. Blood pressure, inflammatory marker levels, and energy intake were measured before and after the study. RESULTS: After 6 weeks, the diet composition of the intervention group changed significantly (p
Source: Clinics - April 9, 2019 Category: General Medicine Source Type: research

Serum Levels of Infliximab and Anti-Infliximab Antibodies in Brazilian Patients with Crohn’s Disease
CONCLUSIONS: The undetectable levels of IFX correlated with the detection of ATIs, which was independent of disease activity. Immunogenicity was not the main factor for the loss of response to IFX in our study, and the majority of patients in both groups (CDA and CDR) had supratherapeutic levels of IFX. (Source: Clinics)
Source: Clinics - April 9, 2019 Category: General Medicine Source Type: research

Logistic regression analysis of clinical and computed tomography features of pulmonary abscesses and risk factors for pulmonary abscess-related empyema
CONCLUSIONS: Transpulmonary fissure abscesses, diabetes, giant pulmonary abscesses, and pleuritic symptoms increased the risk of empyema among patients with pulmonary abscesses. (Source: Clinics)
Source: Clinics - April 9, 2019 Category: General Medicine Source Type: research

Prevalence of sarcopenia and its associated factors: the impact of muscle mass, gait speed, and handgrip strength reference values on reported frequencies
CONCLUSION: In this study, the estimated prevalence of sarcopenia was similar to that reported in most studies after the tailored handgrip strength and gait speed cut-off values were adopted. A higher prevalence was observed when the cut-off values suggested by the European consensus were used. This indicates that the prevalence of sarcopenia must be estimated using population-specific reference values. (Source: Clinics)
Source: Clinics - April 9, 2019 Category: General Medicine Source Type: research

A Brazilian university hospital position regarding transplantation criteria for HIV-positive patients according to the current literature
Human immunodeficiency virus (HIV) infection was considered a contraindication for solid organ transplantation (SOT) in the past. However, HIV management has improved since highly active antiretroviral therapy (HAART) became available in 1996, and the long-term survival of patients living with HIV has led many transplant programs to reevaluate their policies regarding the exclusion of patients with HIV infection. Based on the available data in the medical literature and the cumulative experience of transplantation in HIV-positive patients at our hospital, the aim of the present article is to outline the criteria for transp...
Source: Clinics - April 1, 2019 Category: General Medicine Source Type: research

Specific characteristics of the medical history of swallowing before and after application of botulinum toxin in patients with cervical dystonia
CONCLUSION: The administration of a swallowing-specific questionnaire to individuals with CD befo re and after BTX application enabled the identification of possible dysphagia symptoms prior to drug treatment resulting from CD, which are often subsequently interpreted as side effects of the drug treatment. Thus, dysphagia can be managed, and aspiration symptoms can be prevented. (Source: Clinics)
Source: Clinics - April 1, 2019 Category: General Medicine Source Type: research

Morse taper performance: A finite element analysis study
CONCLUSION: Model 1 showed a higher stress value (1477.5 MPa) at the abutment-retaining screw area t han the stresses found in model 2 (1091.1 MPa for the same area). The cervical bone strain values did not exceed 105 µm for either model. (Source: Clinics)
Source: Clinics - March 25, 2019 Category: General Medicine Source Type: research

Use of technological tools to evaluate handwriting production of the alphabet and pseudocharacters by Brazilian students
CONCLUSION: The results of this study make it possible to verify the interaction failures between the central and peripheral processes, with progression between the 3rd and 5th grade. It also highlights the influence of the lack of systematized teaching of the tracing of letters for Brazilian students since proficiency in calligraphy is critically linked to academic performance. These findings provide a great contribution to Brazilian educational psychology and reflect both educational and clinical practices. (Source: Clinics)
Source: Clinics - March 25, 2019 Category: General Medicine Source Type: research

Work ability and productivity in patients with diabetic foot
OBJECTIVE: To assess work ability and productivity in patients with diabetic foot. METHODS: This investigation was a cross-sectional controlled study. A total of 117 individuals were selected from March to June 2014 and allocated to group A (patients without diabetes, n=43), group B (diabetes patients without foot ulcers, n=43), or group C (patients with diabetic foot, n=31). Two validated instruments, the Work Limitations Questionnaire (WLQ) and the Work Productivity and Activity Impairment Questionnaire General Health v2.0 (WPAI-GH), were used to assess work ability and productivity. RESULTS: The groups were homogeneous ...
Source: Clinics - March 25, 2019 Category: General Medicine Source Type: research

Metabolomics applied to maternal and perinatal health: a review of new frontiers with a translation potential
The prediction or early diagnosis of maternal complications is challenging mostly because the main conditions, such as preeclampsia, preterm birth, fetal growth restriction, and gestational diabetes mellitus, are complex syndromes with multiple underlying mechanisms related to their occurrence. Limited advances in maternal and perinatal health in recent decades with respect to preventing these disorders have led to new approaches, and “ omics ” sciences have emerged as a potential field to be explored. Metabolomics is the study of a set of metabolites in a given sample and can represent the metabolic functionin...
Source: Clinics - March 22, 2019 Category: General Medicine Source Type: research

Epidemiology and outcomes of anal abscess in patients on chronic dialysis: a 14-year retrospective study
CONCLUSION: In chronic dialysis patients with anal abscess, there was no statistically significant difference in clinical presentation and outcomes between the surgical and nonsurgical groups, although the surgical group had a trend of better in-hospital survival. (Source: Clinics)
Source: Clinics - March 22, 2019 Category: General Medicine Source Type: research

CBS promoter hypermethylation increases the risk of hypertension and stroke
In this study, the Cystathionine β -synthase promoter methylation levels of hypertensive and stroke participants were both higher than that of the healthy individuals (median percentages of the methylated reference were 50.61%, 38.05% and 30.53%, respectively, all p
Source: Clinics - March 22, 2019 Category: General Medicine Source Type: research

Caloric test and video head impulse test sensitivity as vestibular impairment predictors before cochlear implant surgery
CONCLUSION: The caloric test is more sensitive than the video head impulse test (Fisher ’ s exact test, p=0.0002) in detecting the impaired ear before cochlear implant delivery. The proportion of caloric test/video head impulse test positive identification of abnormal vestibular function or caloric test/video head impulse test sensitivity was 1.8:1. (Source: Clinics)
Source: Clinics - March 15, 2019 Category: General Medicine Source Type: research

Evaluation of Alternative Halo Ring Positions in Children Using Tomography
CONCLUSIONS: The cranial thickness at all points increases linearly with age. Points 1 and 2 cm above the standard insertion sites are viable alternatives for the placement of halo pins. Preoperative CT can aid in choosing the best positioning sites for pins in the skull. (Source: Clinics)
Source: Clinics - March 15, 2019 Category: General Medicine Source Type: research

Is there any association between osteoporotic vertebral fracture and vitamin K epoxide reductase complex subunit-1 polymorphism in Turkish society? A pilot study
CONCLUSION: There was no relationship between osteoporotic vertebral fracture and VKORC1 gene polymorphism in a postmenopausal Turkish population. (Source: Clinics)
Source: Clinics - March 15, 2019 Category: General Medicine Source Type: research

Lower urinary tract symptoms and sexual dysfunction in men with multiple sclerosis
OBJECTIVES: To assess the prevalence and interrelationship between lower urinary tract symptoms and sexual dysfunction in men with multiple sclerosis (MS). METHODS: In a cross-sectional study, we evaluated 41 men (mean age 41.1 ±9.9 years) with MS from February 2011 to March 2013, who were invited to participate irrespective of the presence of lower urinary tract symptoms or sexual dysfunction. Neurological impairment was assessed with the Expanded Disability Status Scale; lower urinary tract symptoms were evaluated with the International Continence Society male short-form questionnaire, and sexual dysfunction was e...
Source: Clinics - March 15, 2019 Category: General Medicine Source Type: research

Very low-calorie diet in candidates for bariatric surgery: change in body composition during rapid weight loss
CONCLUSIONS: The use of a VLCD before bariatric surgery led to a loss of weight at the expense of body fat over a short period, with no significant differences in the alteration of body composition according to gender, age, body mass index and diabetes status. (Source: Clinics)
Source: Clinics - March 15, 2019 Category: General Medicine Source Type: research

Research progress in ultrasound use for the diagnosis and treatment of cerebrovascular diseases
Cerebrovascular diseases pose a serious threat to human survival and quality of life and represent a major cause of human death and disability. Recently, the incidence of cerebrovascular diseases has increased yearly. Rapid and accurate diagnosis and evaluation of cerebrovascular diseases are of great importance to reduce the incidence, morbidity and mortality of cerebrovascular diseases. With the rapid development of medical ultrasound, the clinical relationship between ultrasound imaging technology and the diagnosis and treatment of cerebrovascular diseases has become increasingly close. Ultrasound techniques such as tra...
Source: Clinics - March 12, 2019 Category: General Medicine Source Type: research

Comparing the effects of vitamin E tocotrienol-rich fraction supplementation and α-tocopherol supplementation on gene expression in healthy older adults
CONCLUSION Supplementation with either α -tocopherol or tocotrienol-rich fraction affected the immune and drug response and the cell adhesion and signal transduction pathways but modulated other pathways differently after 6 months of supplementation, with sex-specific responses. (Source: Clinics)
Source: Clinics - March 12, 2019 Category: General Medicine Source Type: research

Is the effect of melatonin on vascular endothelial growth factor receptor-2 associated with angiogenesis in the rat ovary?
OBJECTIVES Vascular endothelial growth factor (VEGF) and its receptors play important roles in angiogenesis. Melatonin plays an important role in gonadal development; thus, its effect on the reproductive system is evident. We investigated the influence of melatonin on the expression of VEGF, vascular endothelial growth factor receptor-1 (VEGFR1) and vascular endothelial growth factor receptor-2 (VEGFR2), as well as on changes in oxidative stress markers and follicle numbers in rat ovaries. METHODS For this purpose, 45 Wistar rats were separated into the following groups: Group 1, control; Group 2, vehicle; and Group 3, mel...
Source: Clinics - March 12, 2019 Category: General Medicine Source Type: research