Sensitivity of the Wondfo One Step COVID-19 test using serum samples
This study presents a novel description of COVID-19 in abdominal SOT recipients. Furthermore, we alert medical professionals to the higher fatality risk in patients older than 60 years. (PROSPERO, registration number=CRD42020181299) (Source: Clinics)
Source: Clinics - June 3, 2020 Category: General Medicine Source Type: research

Neonatal SARS-CoV-2 infection
This study presents a novel description of COVID-19 in abdominal SOT recipients. Furthermore, we alert medical professionals to the higher fatality risk in patients older than 60 years. (PROSPERO, registration number=CRD42020181299) (Source: Clinics)
Source: Clinics - June 3, 2020 Category: General Medicine Source Type: research

Low incidence of COVID-19 in children and adolescent post-liver transplant at a Latin American reference center
This study presents a novel description of COVID-19 in abdominal SOT recipients. Furthermore, we alert medical professionals to the higher fatality risk in patients older than 60 years. (PROSPERO, registration number=CRD42020181299) (Source: Clinics)
Source: Clinics - June 3, 2020 Category: General Medicine Source Type: research

COVID-19 in solid organ transplantation patients: A systematic review
This study presents a novel description of COVID-19 in abdominal SOT recipients. Furthermore, we alert medical professionals to the higher fatality risk in patients older than 60 years. (PROSPERO, registration number=CRD42020181299) (Source: Clinics)
Source: Clinics - June 3, 2020 Category: General Medicine Source Type: research

COVID-19 and pediatric inflammatory bowel disease: How to manage it?
Pediatric gastroenterologists, family members, and caregivers of patients with inflammatory bowel disease (IBD) are on alert; they are all focused on implementing prophylactic measures to prevent infection by severe acute respiratory syndrome coronavirus 2, evaluating the risks in each patient, guiding them in their treatment, and keeping IBD in remission. To face the current issues of the coronavirus disease pandemic, we have developed a synthesis of the main recommendations of the literature directed at pediatric gastroenterologists in control of patients with pediatric IBD and adapted to the national reality. (Source: Clinics)
Source: Clinics - June 3, 2020 Category: General Medicine Source Type: research

Effects and mechanism of stem cells from human exfoliated deciduous teeth combined with hyperbaric oxygen therapy in type 2 diabetic rats
CONCLUSION: SHED combined with HBO therapy was effective for treating type 2 diabetic rats. The underlying mechanism may involve SHED-mediated increase in the proliferation and trans-differentiation of islet β -cells and decrease in pro-inflammatory cytokines and apoptosis of islets. (Source: Clinics)
Source: Clinics - June 3, 2020 Category: General Medicine Source Type: research

Clinical and laboratory parameters as predictors of long-term outcome according to the etiology of underlying chronic liver disease in patients who underwent liver transplantation for hepatocellular carcinoma treatment
This study aimed to analyze clinical and laboratory parameters and their association with long-term outcomes in patients who underwent liver transplantation for hepatocellular carcinoma treatment, according to the etiology of the underlying chronic liver disease, in order to identify predictors of response to this therapeutic modality. METHODS: Demographic, clinical, and laboratory data from a cohort of 134 patients who underwent orthotopic liver transplantation for hepatocellular carcinoma treatment at a referral center in Brazil were retrospectively selected and compared according to the etiologic group of the underlying...
Source: Clinics - June 3, 2020 Category: General Medicine Source Type: research

How Institutions Can Protect the Mental Health and Psychosocial Well-Being of Their Healthcare Workers in the Current COVID-19 Pandemic
(Source: Clinics)
Source: Clinics - June 3, 2020 Category: General Medicine Source Type: research

Ultrasound-guided minimally invasive autopsies: A protocol for the study of pulmonary and systemic involvement of COVID-19
Considering that female sexual hormones may modulate the inflammatory response and also exhibit direct effects on the cells of the immune system, herein, we intend to discuss the sex differences and the role of estradiol in modulating the lung and systemic inflammatory response, focusing on its possible application as a treatment modality for SARS-CoV-2 patients. COVID-19 patients develop severe hypoxemia early in the course of the disease, which is silent most of the time. Small fibrinous thrombi in pulmonary arterioles and a tumefaction of endothelial were observed in the autopsies of fatal COVID-19 cases. Studies showed...
Source: Clinics - May 30, 2020 Category: General Medicine Source Type: research

COVID-19 Pandemic as a Driver for Spreading Virtual Care Globally: The Future Starts Now
Considering that female sexual hormones may modulate the inflammatory response and also exhibit direct effects on the cells of the immune system, herein, we intend to discuss the sex differences and the role of estradiol in modulating the lung and systemic inflammatory response, focusing on its possible application as a treatment modality for SARS-CoV-2 patients. COVID-19 patients develop severe hypoxemia early in the course of the disease, which is silent most of the time. Small fibrinous thrombi in pulmonary arterioles and a tumefaction of endothelial were observed in the autopsies of fatal COVID-19 cases. Studies showed...
Source: Clinics - May 30, 2020 Category: General Medicine Source Type: research

Technological Innovation in Outpatient Assistance for Chronic Liver Disease and Liver Transplant Patients During the Coronavirus Disease Outbreak: A Method to Minimize Transmission
Considering that female sexual hormones may modulate the inflammatory response and also exhibit direct effects on the cells of the immune system, herein, we intend to discuss the sex differences and the role of estradiol in modulating the lung and systemic inflammatory response, focusing on its possible application as a treatment modality for SARS-CoV-2 patients. COVID-19 patients develop severe hypoxemia early in the course of the disease, which is silent most of the time. Small fibrinous thrombi in pulmonary arterioles and a tumefaction of endothelial were observed in the autopsies of fatal COVID-19 cases. Studies showed...
Source: Clinics - May 30, 2020 Category: General Medicine Source Type: research

17β-Estradiol, a potential ally to alleviate SARS-CoV-2 infection
Considering that female sexual hormones may modulate the inflammatory response and also exhibit direct effects on the cells of the immune system, herein, we intend to discuss the sex differences and the role of estradiol in modulating the lung and systemic inflammatory response, focusing on its possible application as a treatment modality for SARS-CoV-2 patients. COVID-19 patients develop severe hypoxemia early in the course of the disease, which is silent most of the time. Small fibrinous thrombi in pulmonary arterioles and a tumefaction of endothelial were observed in the autopsies of fatal COVID-19 cases. Studies showed...
Source: Clinics - May 30, 2020 Category: General Medicine Source Type: research

Health literacy and depression in women with type 2 diabetes mellitus
CONCLUSIONS: A negative correlation was identified between health literacy and depression. Self-rated health status, economic satisfaction, employment status, and higher education level are factors that also affect depressive tendency among diabetic women. (Source: Clinics)
Source: Clinics - May 30, 2020 Category: General Medicine Source Type: research

COVID-19, Vascular Diseases, and Vascular Services
(Source: Clinics)
Source: Clinics - May 30, 2020 Category: General Medicine Source Type: research

Lung transplantation during the COVID-19 pandemic
(Source: Clinics)
Source: Clinics - May 30, 2020 Category: General Medicine Source Type: research

Social media: friend or foe in the COVID-19 pandemic?
This article presents expert recommendations for assisting newborn children of mothers with suspected or diagnosed coronavirus disease 2019(COVID-19). The consensus was developed by five experts with an average of 20 years of experience in neonatal intensive care working at a reference university hospital in Brazil for the care of pregnant women and newborns with suspected or confirmed COVID-19. Despite the lack of scientific evidence regarding the potential for viral transmission to their fetus in pregnant mothers diagnosed with or suspected of COVID-19, it is important to elaborate the lines of care by specialists from h...
Source: Clinics - May 15, 2020 Category: General Medicine Source Type: research

Expert recommendations for the care of newborns of mothers with COVID-19
This article presents expert recommendations for assisting newborn children of mothers with suspected or diagnosed coronavirus disease 2019(COVID-19). The consensus was developed by five experts with an average of 20 years of experience in neonatal intensive care working at a reference university hospital in Brazil for the care of pregnant women and newborns with suspected or confirmed COVID-19. Despite the lack of scientific evidence regarding the potential for viral transmission to their fetus in pregnant mothers diagnosed with or suspected of COVID-19, it is important to elaborate the lines of care by specialists from h...
Source: Clinics - May 15, 2020 Category: General Medicine Source Type: research

Surgical Practice in the Current COVID-19 Pandemic: A Rapid Systematic Review
The coronavirus disease (COVID-19) outbreakstarted in Wuhan, China, in December 2019, and evolved into a global problem in a short period. The pandemic has led to many social and health-care challenges. In this context, surgery is an area that is facing the need for many adaptations. In this systematic literature review, we analyzed different perspectives concerning this situation, aiming to provide recommendations that could guide surgeons andentities toward screening, elective and emergency surgeries, decision making, and operating room management. A computerized search in PubMed, Scopus, and Scientific Electronic Librar...
Source: Clinics - May 15, 2020 Category: General Medicine Source Type: research

Susceptibility of the Elderly to SARS-CoV-2 Infection: ACE-2 Overexpression, Shedding, and Antibody-dependent Enhancement (ADE)
The world is currently facing a serious SARS-CoV-2 infection pandemic.This virus is a new isolate of coronavirus, and the current infection crisis has surpassed the SARS and MERS epidemics that occurred in 2002 and 2013, respectively. SARS-CoV-2 has currently infected more than 142,000 people, causing5,000 deaths and spreading across more than 130countries worldwide. The spreading capacity of the virus clearly demonstrates the potential threatof respiratory viruses to human health, thereby reiterating to the governments around the world that preventivehealth policies and scientific research are pivotal to overcoming the cr...
Source: Clinics - May 15, 2020 Category: General Medicine Source Type: research

Association between platelet count and the risk and progression of hand, foot, and mouth disease among children
CONCLUSIONS: PLT was independently associated with HFMD progression in a nonlinear manner. (Source: Clinics)
Source: Clinics - May 15, 2020 Category: General Medicine Source Type: research

Why is SARS-CoV-2 infection milder among children?
(Source: Clinics)
Source: Clinics - May 15, 2020 Category: General Medicine Source Type: research

I am having trouble keeping up with virtual teaching activities: Reflections in the COVID-19 era
The world is fighting the COVID-19 outbreak and health workers, including inflammatory bowel diseases specialists, have been challenged to address the specific clinical issues of their patients. We hereby summarize the current literature in the management of inflammatory bowel disease (IBD) patients during the COVID-19 pandemic era that support the rearrangement of our IBD unit and the clinical advice provided to our patients. (Source: Clinics)
Source: Clinics - May 9, 2020 Category: General Medicine Source Type: research

Do we have enough evidence to use chloroquine/hydroxychloroquine as a public health panacea for COVID-19?
The world is fighting the COVID-19 outbreak and health workers, including inflammatory bowel diseases specialists, have been challenged to address the specific clinical issues of their patients. We hereby summarize the current literature in the management of inflammatory bowel disease (IBD) patients during the COVID-19 pandemic era that support the rearrangement of our IBD unit and the clinical advice provided to our patients. (Source: Clinics)
Source: Clinics - May 9, 2020 Category: General Medicine Source Type: research

Posterior Capsule Opacification after Cataract Surgery in Children Over Five Years of Age with Square-edge Hydrophobic versus Hydrophilic Acrylic Intraocular Lenses: A Prospective Randomized Study
CONCLUSIONS: No differences in PCO rates were found between hydr ophobic and hydrophilic acrylic square-edged IOLs in children between five and twelve years of age at one year of follow-up. (Source: Clinics)
Source: Clinics - May 9, 2020 Category: General Medicine Source Type: research

Norm scores of cancelation and bisection tests for unilateral spatial neglect: data from a Brazilian population
OBJECTIVE: Unilateral spatial neglect (USN) results in a consistent and exaggerated spatial asymmetry in the processing of information about the body or space due to an acquired brain injury. There are several USN tests for clinical diagnosis, but none of them are validated in Brazil. The aim was to obtain normative values from a healthy sample in Brazil and to evaluate the effects of demographic variables on USN tests. METHODS: This was a cross-sectional study performed with 150 neurologically healthy individuals. USN was evaluated using the line cancelation (LC), star cancelation (SC), and line bisection (LB) tests in th...
Source: Clinics - May 9, 2020 Category: General Medicine Source Type: research

Medical care for spinal diseases during the COVID-19 pandemic
(Source: Clinics)
Source: Clinics - May 9, 2020 Category: General Medicine Source Type: research

Spotlight for healthy adolescents and adolescents with preexisting chronic diseases during the COVID-19 pandemic
(Source: Clinics)
Source: Clinics - May 9, 2020 Category: General Medicine Source Type: research

A company doctor's role during the COVID-19 pandemic
(Source: Clinics)
Source: Clinics - May 9, 2020 Category: General Medicine Source Type: research

Alcohol and sudden unexpected death in epilepsy: do not pop the cork
(Source: Clinics)
Source: Clinics - May 9, 2020 Category: General Medicine Source Type: research

Errata
The world is fighting the COVID-19 outbreak and health workers, including inflammatory bowel diseases specialists, have been challenged to address the specific clinical issues of their patients. We hereby summarize the current literature in the management of inflammatory bowel disease (IBD) patients during the COVID-19 pandemic era that support the rearrangement of our IBD unit and the clinical advice provided to our patients. (Source: Clinics)
Source: Clinics - May 1, 2020 Category: General Medicine Source Type: research

Reproducibility of a nylon fishing line as a screening test for diabetic foot ulceration risk
The world is fighting the COVID-19 outbreak and health workers, including inflammatory bowel diseases specialists, have been challenged to address the specific clinical issues of their patients. We hereby summarize the current literature in the management of inflammatory bowel disease (IBD) patients during the COVID-19 pandemic era that support the rearrangement of our IBD unit and the clinical advice provided to our patients. (Source: Clinics)
Source: Clinics - May 1, 2020 Category: General Medicine Source Type: research

Extracorporeal Membrane Oxygenation and Lung Transplantation: Initial Experience at a Single Brazilian Center
CONCLUSION: Lun g transplantation requires complex treatment, and ECMO has allowed extending the indications for transplantation and provided adjuvant support in the clinical management of these patients. (Source: Clinics)
Source: Clinics - May 1, 2020 Category: General Medicine Source Type: research

Mechanical evaluation of tibial fixation of the hamstring tendon in anterior cruciate ligament double-bundle reconstruction with and without interference screws
CONCLUSION: The use of the native insertion of the semitendineous and gracilis tendons, without an additional fixation device, presented mechanical superiority over their fixation with interference screws. (Source: Clinics)
Source: Clinics - May 1, 2020 Category: General Medicine Source Type: research

Management of inflammatory bowel disease patients in the COVID-19 pandemic era: a Brazilian tertiary referral center guidance
The world is fighting the COVID-19 outbreak and health workers, including inflammatory bowel diseases specialists, have been challenged to address the specific clinical issues of their patients. We hereby summarize the current literature in the management of inflammatory bowel disease (IBD) patients during the COVID-19 pandemic era that support the rearrangement of our IBD unit and the clinical advice provided to our patients. (Source: Clinics)
Source: Clinics - April 18, 2020 Category: General Medicine Source Type: research

COVID-19 Diagnostic and Management Protocol for Pediatric Patients
This review aims to verify the main epidemiologic, clinical, laboratory-related, and therapeutic aspects of coronavirus disease 2019 (COVID-19) in critically ill pediatric patients. An extensive review of the medical literature on COVID-19 was performed, mainly focusing on the critical care of pediatric patients, considering expert opinions and recent reports related to this new disease. Experts from a large Brazilian public university analyzed all recently published material to produce a report aiming to standardize the care of critically ill children and adolescents. The report emphasizes on the clinical presentations of...
Source: Clinics - April 18, 2020 Category: General Medicine Source Type: research

Neuropsychiatric Lupus Erythematosus: Future Directions and Challenges; a Systematic Review and Survey
This study aimed to systematically review neuropsychiatric lupus erythematosus (NPSLE) and establish a simplified diagnostic criterion for NPSLE. Publications from 1994 to 2018 in the database (Wanfang data (http://www.wanfangdata.com.cn/index.html) and China National Knowledge Internet (http://www.cnki.net)) were included. In total, 284 original case reports and 24 unpublished cases were collected, and clinical parameters were analyzed. An attempt was made to develop a set of simplified diagnostic criteria for NPSLE based on cases described in the survey and literature; moreover, and pathophysiology and management guideli...
Source: Clinics - April 18, 2020 Category: General Medicine Source Type: research

Relationship between Neutrophil-to-Lymphocyte Ratio and Systemic Lupus Erythematosus: A Meta-analysis
Systemic lupus erythematosus (SLE) is a chronic systematic autoimmune disease. Current methods of diagnosing SLE or evaluating its activity are complex and expensive. Numerous studies have suggested that neutrophil-to-lymphocyte ratio (NLR) is closely correlated with the presence of SLE and its activity, suggesting that it may serve as a diagnostic and monitoring indicator for SLE. Therefore, we performed a meta-analysis to systematically assess the association between NLR and SLE. We performed a literature search until 12 April 2019 in the PubMed, Web of Science, and China National Knowledge Infrastructure databases. Cros...
Source: Clinics - April 18, 2020 Category: General Medicine Source Type: research

Beneficial effect of fluid warming in elderly patients with bladder cancer undergoing Da Vinci robotic-assisted laparoscopic radical cystectomy
This study aimed to investigate the efficacy of fluid warming nursing in elderly patients undergoing Da Vinci robotic-assisted laparoscopic radical cystectomy. METHODS: A total of 108 patients with bladder cancer scheduled to undergo DaVinci robotic-assisted laparoscopic radical cystectomy were recruited and randomly divided into the control group (n=55), which received a warming blanket (43 °C) during the intraoperative period and the warming group (n=53), in which all intraoperative fluids were administered via a fluid warmer (41°C). The surgical data, body temperature, coagulation function indexes, and postopera...
Source: Clinics - April 18, 2020 Category: General Medicine Source Type: research

Profile of health professionals who completed a master’s, doctoral, or post-doctoral degree in one Brazilian pediatric program
CONCLUSIONS: The majority of master ’ s-, doctoral-, and post-doctoral-level health professionals were women and physicians, and had published their thesis. Younger postgraduates and women reported low salaries, less likelihood of working>40 hours/week, and less overall satisfaction with their profession. Further longitudinal and qualitative studies are warranted to assess career trajectories after graduation. (Source: Clinics)
Source: Clinics - April 18, 2020 Category: General Medicine Source Type: research

Real-world evidence of health outcomes and medication use 24 months after bariatric surgery in the public healthcare system in Brazil: a retrospective, single-center study
CONCLUSION: Roux-en-Y gastric bypass successfully reduced weight, BMI, and comorbidities and medication use and cost at 24 months in Brazilian patients treated in the public Unified Health System. (Source: Clinics)
Source: Clinics - April 10, 2020 Category: General Medicine Source Type: research

Salvage treatment for refractory or relapsed acute myeloid leukemia: a 10-year single-center experience
OBJECTIVES: The outcomes of refractory and relapsed acute myeloid leukemia (AML) patients in developing countries are underreported, even though the similar classic regimens are widely used. METHODS: We conducted a retrospective comparison of “ MEC ” (mitoxantrone, etoposide, and cytarabine) and “ FLAG-IDA ” (fludarabine, cytarabine, idarubicin, and filgrastim) in adults with first relapse or refractory AML. RESULTS: In total, 60 patients were included, of which 28 patients received MEC and 32 received FLAG-IDA. A complete response (CR) rate of 48.3% was observed. Of the included patients, 16 (27%) ...
Source: Clinics - April 10, 2020 Category: General Medicine Source Type: research

Survival trends of patients with oral and oropharyngeal cancer treated at a cancer center in São Paulo, Brazil
CONCLUSION: Survival across the two time periods remained stable for oral SCC but showed a significant increase for oropharyngeal SCC, possibly because of improvements in the patients ’ response to radiotherapy, such as intensity-modulated radiation therapy, and the use of more accurate diagnostic imaging approaches. (Source: Clinics)
Source: Clinics - April 10, 2020 Category: General Medicine Source Type: research

Sensitivity and specificity of a low-cost screening protocol for identifying children at risk for language disorders
CONCLUSIONS: The screening test showed high diagnostic efficiency in determining the risk of language disorders in children aged between 0 and 5 years. (Source: Clinics)
Source: Clinics - April 10, 2020 Category: General Medicine Source Type: research

The Importance of Scientific Publications in Times of Pandemic Crisis
(Source: Clinics)
Source: Clinics - April 10, 2020 Category: General Medicine Source Type: research

How should health systems prepare for the evolving COVID-19 pandemic? Reflections from the perspective of a Tertiary Cancer Center
(Source: Clinics)
Source: Clinics - April 10, 2020 Category: General Medicine Source Type: research

Surgical Sympathectomy: Can it be useful in cardiology?
(Source: Clinics)
Source: Clinics - April 10, 2020 Category: General Medicine Source Type: research

Effects of anastrozole on Ki-67 antigen expression in the vaginal epithelium of female rats in persistent estrus
OBJECTIVES: Aromatase inhibitors are the first-choice drugs for the treatment of hormone sensitive breast cancer. However, in addition to the scarcity of studies, there are controversies about their effects on vaginal epithelial cell proliferation in rats, especially those in persistent estrus. METHODS: To investigate vaginal epithelial cell proliferation by Ki-67 antigen expression, persistent estrus was induced in 42 randomly selected rats. These rats were randomly divided into 2 groups: group I (control, n=21), which received 0.1 mL of propylene glycol (vehicle) daily, and group II (experimental, n=21), which received 0...
Source: Clinics - April 4, 2020 Category: General Medicine Source Type: research

Posturographic measures did not improve the predictive power to identify recurrent falls in community-dwelling elderly fallers
This study aimed to evaluate if posturography can be considered a recurrent fall predictor in elderly individuals. METHODS: This was a cross-sectional study. A total of 124 subjects aged 60 to 88 years were evaluated and divided into two groups — the recurrent fallers (89) and single fallers (35) groups. Patients ’ sociodemographic characteristics were assessed, and clinical testing was performed. The functional test assessment instruments used were timed up and go test (TUGT), Berg Balance Scale (BBS), five times sit-to-stand test, and Falls Efficacy Scale (to measure fear of falling). Static posturography was...
Source: Clinics - April 4, 2020 Category: General Medicine Source Type: research

Opioid-induced immunosuppression and carcinogenesis promotion theories create the newest trend in acute and chronic pain pharmacotherapy
Opioids are the main group of pharmacological agents used during the perioperative period and provide a sedative and analgesic component. The observations of opioid consumption in West Europe indicate that this group of drugs is widely used in chronic noncancer pain therapy. Nearly 20 years ago, the first publications indicating that opioids, as an element of perioperative pharmacotherapy in oncologic patients, increase the risk of tumor recurrence and affect further prognosis were presented. The actual publications suggest that there are multifactorial, complex mechanisms underlying the immunological impact and carcinogen...
Source: Clinics - March 24, 2020 Category: General Medicine Source Type: research

Choledochal cysts in children: How to Diagnose and Operate on
CONCLUSION: In patients with choledochal cysts, US is the only necessary diagnostic imaging. Performing the bile enteric anastomosis in the lower portion of the common hepatic duct is safer and has a lower risk of com plications. (Source: Clinics)
Source: Clinics - March 24, 2020 Category: General Medicine Source Type: research