Association between matrix metalloproteinase-9 gene polymorphism and breast cancer in Brazilian women
This study aimed to determine the relationship between rs17576 (MMP-9) polymorphism and increased cancer risk in a Brazilian breast cancer cohort. METHODS: This study included 141 women (71 breast cancer patients and 70 controls without breast cancer) who donated 3 mL of their peripheral blood for genomic DNA extraction. This DNA was then genotyped using a real-time polymerase chain reaction. RESULTS: The AG (rs17576) genotype was identified in 26 (18.43%) participants in the case group and in 22 (15.60%) participants in the control group (p=0.274), while the GG genotype was identified in ten (7.09%) participants in the ca...
Source: Clinics - October 26, 2020 Category: General Medicine Source Type: research

Interaction between cognitive status, fear of falling, and balance in elderly persons
CONCLUSION: Elderly persons with cognitive decline have lower balance, greater fear of falling, and greater recurrence of falls. (Source: Clinics)
Source: Clinics - October 26, 2020 Category: General Medicine Source Type: research

Erratum for: Cross-cultural validation of the FACE-Q Satisfaction with Facial Appearance Overall Scale (FACE-Q SFAOS) in Brazilian rhytidoplasty patients
Conclusions: Ultrasound echotexture may detect chronic sialadenitis secondary to salivary radioiodine therapy. (Source: Clinics)
Source: Clinics - October 19, 2020 Category: General Medicine Source Type: research

Ultrasonography Echotexture as a surrogate for Sialadenitis secondary to 131I Radioiodine Therapy for differentiated Thyroid Cancer: a review and metaanalysis
Conclusions: Ultrasound echotexture may detect chronic sialadenitis secondary to salivary radioiodine therapy. (Source: Clinics)
Source: Clinics - October 19, 2020 Category: General Medicine Source Type: research

Serum interleukin-6 level is correlated with the disease activity of systemic lupus erythematosus: a meta-analysis
Interleukin-6 (IL-6) plays a crucial role in systemic autoimmunity and pathologic inflammation. Numerous studies have explored serum IL-6 levels in systemic lupus erythematosus (SLE) and their correlation with disease activity. Here, we performed a meta-analysis to quantitatively assess the correlation between the serum IL-6 levels and SLE activity. The PubMed and EMBASE databases were thoroughly searched for relevant studies up to September 2019. Standardized mean differences (SMDs) with 95% confidence intervals (95% CIs) were used to describe the differences between serum IL-6 levels in SLE patients and healthy controls ...
Source: Clinics - October 19, 2020 Category: General Medicine Source Type: research

Endobronchial ultrasound-guided transbronchial needle aspiration combined with either endoscopic ultrasound-guided fine-needle aspiration or endoscopic ultrasound using the EBUS scope-guided fine-needle aspiration for diagnosing and staging mediastinal diseases: a systematic review and meta-analysis
The present systematic review and meta-analysis aimed to evaluate the available evidence base on endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) combined with either endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) or endoscopic ultrasound using the EBUS scope-guided fine-needle aspiration (EUS-B-FNA) for diagnosing and staging mediastinal diseases. PubMed, Web of Science, and Embase were searched to identify suitable studies up to June 30, 2019. Two investigators independently reviewed articles and extracted relevant data. Data were pooled using random effect models to calculate d...
Source: Clinics - October 19, 2020 Category: General Medicine Source Type: research

Real-World Molecular Testing and Treatment Patterns in Brazilian Patients with Newly Diagnosed Locally Advanced or Metastatic NSCLC
Conclusion: Our findings provide relevant information for prescribers and policy decision-makers by highlighting the unmet needs of patients and the importance of molecular testing in newly diagnosed locally advanced or metastatic lung adenocarcinoma. We also highlight the respective EGFR-tyrosine kinase inhibitor treatment when the result is positive and the areas in which further efforts are required to grant access to effective treatment. (Source: Clinics)
Source: Clinics - October 19, 2020 Category: General Medicine Source Type: research

Diagnostic value of volumetric capnography in patients with chronic cough variant asthma
OBJECTIVES: To evaluate the quantitative changes and diagnostic performance of volumetric capnography (VCap) parameters in patients with cough variant asthma. METHODS: This cross-sectional study enrolled 31 patients with cough variant asthma and 30 patients with chronic cough without asthma between November 2010 and March 2012. VCap measurements were recorded at baseline, during the five steps of the histamine challenge, and after bronchodilation with salbutamol. They were then compared between the baseline and histamine challenge, and between the two groups. Receiver operating characteristic curve analysis was performed f...
Source: Clinics - October 19, 2020 Category: General Medicine Source Type: research

Sepsis and cirrhosis in growing animals: description of a new experimental model and its pathological and immunological reliability
The objectives of the current study were therefore to develop an experimental model of infection and sepsis in cirrhotic weaning growing rats, by the use of bile duct ligation (BDL) and cecal ligation and puncture (CLP). Additionally, the correlation of the clinico-histopathological data and serial cytokine levels in septic cirrhotic and non-cirrhotic animals was studied. METHODS: Young Wistar rats of age 21 days and of weight between 70-90 g were divided into 12 groups according to the surgical procedure performed: sham (sacrificed after 2 or 4 weeks), BDL (sacrificed after 2 or 4 weeks), CLP (2- or 4-week old animals sac...
Source: Clinics - September 28, 2020 Category: General Medicine Source Type: research

Unexpectedly High Prevalence of Low Alpha-Galactosidase A Enzyme Activity in Patients with Focal Segmental Glomerulosclerosis
CONCLUSIONS: We found that α GAL activity in patients with FSGS is lower than that in patients undergoing HD. The low enzyme activity in patients with FSGS may be explained by considering the similar pathogenesis of FSGS and FD, which may also lead to sphingolipid deposition and podocyte injury. (Source: Clinics)
Source: Clinics - September 28, 2020 Category: General Medicine Source Type: research

Ketamine ameliorates hypoxia-induced endothelial injury in human umbilical vein endothelial cells
CONCLUSION: Ketamine reduces hypoxia-induced p66Shc expression and attenuates ROS accumulation via upregulating sirt1 in HUVECs, thus attenuating hypoxia-induced endothelial cell inflammation and apoptosis. (Source: Clinics)
Source: Clinics - September 11, 2020 Category: General Medicine Source Type: research

Comparative tomographic study of the iliac screw and the S2-alar-iliac screw in children
CONCLUSIONS: Through CT, the S2AI screw trajectory was observed to have a greater bone thickness and skin distance than the IS. There was a linear correlation between age and screw length for both techniques. A similar relationship was observed between skin distance and age for the S2AI screw technique. In children, the S2AI screw technique presents advantages such as greater cutaneous coverage and implant thickness than the IS technique. (Source: Clinics)
Source: Clinics - September 11, 2020 Category: General Medicine Source Type: research

Accuracy of a portable breath meter test for the detection of halitosis in children and adolescents
CONCLUSION: In the present study involving children, who require fast, practical examinations, BA proved to be an auxiliary tool to OT for the detection of halitosis in the practice of pediatric dentistry, demonstrating high sensitivity and specificity. (Source: Clinics)
Source: Clinics - September 11, 2020 Category: General Medicine Source Type: research

Application of acoustic radiation force impulse elastography combined with serum markers in Child-Pugh grading
In this study, we investigated the relationship between ARFI elastography combined with either AAR, APRI, or FIB-4 index and Child-Pugh (CP) class for the evaluation of hepatic functional reserve in patients with chronic hepatitis B (CHB)-related cirrhosis. METHODS: The shear wave velocities of 104 patients with clinically confirmed CHB-related cirrhosis were determined using the ARFI; and clinical serum markers (e.g. ALT, AST, PLT) were used to calculate the AAR, APRI, and FIB-4 index. Cirrhosis patients were scored according to their CP class. The ARFI, AAR, APRI, and FIB-4 index were compared with the CP class. The effi...
Source: Clinics - September 11, 2020 Category: General Medicine Source Type: research

Patterns of recurrence and outcomes of glioblastoma multiforme treated with chemoradiation and adjuvant temozolomide
CONCLUSION: The median OS of Brazilian patients with GBM treated with RT and TMZ was satisfactory. Although TMZ therapy has become the standard of care for patients with newly diagnosed GBM, the recurrence rate is extremely high. Metronomic TMZ as salvage treatment improved survival in these patients. (Source: Clinics)
Source: Clinics - September 11, 2020 Category: General Medicine Source Type: research

Erratum for: Salvage treatment for refractory or relapsed acute myeloid leukemia: a 10-year single-center experience
The aim of this study was to evaluate whether there is a relationship between bleeding response and radiotherapy dose to palliate patients with local recurrence or progression of gastric cancer (GC). To this end, we conducted a systematic review and meta-analysis of observational studies that evaluated the bleeding response in patients with GC with local recurrence or progression. A meta-regression analysis between biological effective dose (BED) and bleeding response was performed, as was subgroup analysis to evaluate the outcome by BED level and radiotherapy (RT) technique. A p-value
Source: Clinics - September 2, 2020 Category: General Medicine Source Type: research

Ulcer pressure prevention and opportunity for innovation during the COVID-19 crisis
The aim of this study was to evaluate whether there is a relationship between bleeding response and radiotherapy dose to palliate patients with local recurrence or progression of gastric cancer (GC). To this end, we conducted a systematic review and meta-analysis of observational studies that evaluated the bleeding response in patients with GC with local recurrence or progression. A meta-regression analysis between biological effective dose (BED) and bleeding response was performed, as was subgroup analysis to evaluate the outcome by BED level and radiotherapy (RT) technique. A p-value
Source: Clinics - September 2, 2020 Category: General Medicine Source Type: research

Palliative radiotherapy for gastric cancer: Is there a dose relationship between bleeding response and radiotherapy?
The aim of this study was to evaluate whether there is a relationship between bleeding response and radiotherapy dose to palliate patients with local recurrence or progression of gastric cancer (GC). To this end, we conducted a systematic review and meta-analysis of observational studies that evaluated the bleeding response in patients with GC with local recurrence or progression. A meta-regression analysis between biological effective dose (BED) and bleeding response was performed, as was subgroup analysis to evaluate the outcome by BED level and radiotherapy (RT) technique. A p-value
Source: Clinics - September 2, 2020 Category: General Medicine Source Type: research

Aprepitant plus palonosetron for the prevention of postoperative nausea and vomiting after breast cancer surgery: a double blind, randomized trial
CONCLUSION: The addition of aprepitant as a third antiemetic resulted in no significant reduction in the incidence of PONV in this population. However, the incidence of PONV was reduced in relation to the general population. (Source: Clinics)
Source: Clinics - September 2, 2020 Category: General Medicine Source Type: research

Characteristics and outcomes of patients with COVID-19 admitted to the ICU in a university hospital in São Paulo, Brazil - study protocol
CONCLUSIONS: This study will provide epidemiological data about critically ill patients with COVID-19 in Brazil, which could inform health policy and resource allocation in low- and middle-income countries. (Source: Clinics)
Source: Clinics - August 26, 2020 Category: General Medicine Source Type: research

Physical activity among women of low socioeconomic status living with HIV in two major cities of Brazil and Mozambique: A cross-sectional comparative study
This study compared the PA assessed by accelerometers in women of low SES living with HIV under common antiretroviral therapy (cART) from two major cities in Brazil (Rio de Janeiro, n=33; 40.1 ±6.1 years) and Mozambique (Maputo, n=50; 38.8±8.7 years). METHODS: Eligible women wore triaxial accelerometers during seven consecutive days, to estimate their habitual PA and daily energy expenditure. RESULTS: The proportion of participants with overweight/obesity was greater in Rio than Maput o (57% vs. 30%; p=0.021), as well as those classified as sedentary based on steps/day (45% vs. 22%; p=0.02). Sedentary time wa...
Source: Clinics - August 26, 2020 Category: General Medicine Source Type: research

Association of bone mineral density with bone texture attributes extracted using routine magnetic resonance imaging
OBJECTIVE: Dual-energy X-ray absorptiometry (DXA)-derived bone mineral density (BMD) often fails to predict fragility fractures. Quantitative textural analysis using magnetic resonance imaging (MRI) may potentially yield useful radiomic features to predict fractures. We aimed to investigate the correlation between BMD and texture attributes (TAs) extracted from MRI scans and the interobserver reproducibility of the analysis. METHODS: Forty-nine volunteers underwent lumbar spine 1.5-T MRI and DXA. Three-dimensional (3-D) gray-level co-occurrence matrices were measured from routine sagittal T2 fast spin-echo images using the...
Source: Clinics - August 26, 2020 Category: General Medicine Source Type: research

Cost Modifications during the Early Years of the Use of the National Cardiovascular Data Registry for Quality Improvement
CONCLUSION: The use of the NCDR® as a benchmark to guide QI programs outside the United States was associated with the positive impact of bending the cost curve to below that of national medical inflation and the comparison hospitals ’ costs, with a lower incidence of hospital readmission. (Source: Clinics)
Source: Clinics - August 26, 2020 Category: General Medicine Source Type: research

Cut-off point for high dysphonia risk in children based on the Child Dysphonia Risk Screening Protocol: preliminary findings
CONCLUSION: A cut-off point for high dysphonia risk was calculated. The DRSP-C proved to be a promising tool for children ’ s clinical vocal and health promotion and should be used in conjunction with General Dysphonia Risk Screening. (Source: Clinics)
Source: Clinics - August 26, 2020 Category: General Medicine Source Type: research

Circulating Exosomal microRNAs as Biomarkers of Systemic Lupus Erythematosus
OBJECTIVES: Many studies indicate that microRNAs (miRNAs) could be potential biomarkers for various diseases. The purpose of this study was to investigate the clinical value of serum exosomal miRNAs in systemic lupus erythematosus (SLE). METHODS: Serum exosomes were isolated from 38 patients with SLE and 18 healthy controls (HCs). The expression of miR-21, miR-146a and miR-155 within exosomes was examined by reverse transcription-quantitative polymerase chain reaction (RT-qPCR). Using receiver operating characteristic (ROC) curves, we evaluated the diagnostic value of exosomal miRNAs. RESULTS: Exosomal miR-21 and miR-155 were upregulated (p
Source: Clinics - August 26, 2020 Category: General Medicine Source Type: research

The interference of COVID-19 in the male reproductive system: Important questions and the future of assisted reproduction techniques
(Source: Clinics)
Source: Clinics - August 26, 2020 Category: General Medicine Source Type: research

The influence of bitter-taste receptor (TAS2R) expression in pharmacological response to Chloroquine in obese patients with COVID-19
(Source: Clinics)
Source: Clinics - August 26, 2020 Category: General Medicine Source Type: research

Contributions of residents from multiple specializations in managing the COVID-19 pandemic in the largest public hospital Brazil
Rotator cuff tears are common among the elderly, and studies on the outcomes after rotator cuff repair in the elderly are limited. We carried out this meta-analysis with systematic literature search, aiming to clarify the outcomes after rotator cuff repair in the elderly as assessed by the American Shoulder and Elbow Surgeons (ASES) shoulder score. We conducted a literature search through October 2019 in PubMed and EMBASE databases and performed meta-analysis to calculate the summary mean difference comparing the post- and pre-operation ASES scores under both fixed-effect and random-effect models. Among 4978 studies identi...
Source: Clinics - August 20, 2020 Category: General Medicine Source Type: research

Parathyroid surgery during the COVID-19 pandemic: Time to think about the “New Normal”
Rotator cuff tears are common among the elderly, and studies on the outcomes after rotator cuff repair in the elderly are limited. We carried out this meta-analysis with systematic literature search, aiming to clarify the outcomes after rotator cuff repair in the elderly as assessed by the American Shoulder and Elbow Surgeons (ASES) shoulder score. We conducted a literature search through October 2019 in PubMed and EMBASE databases and performed meta-analysis to calculate the summary mean difference comparing the post- and pre-operation ASES scores under both fixed-effect and random-effect models. Among 4978 studies identi...
Source: Clinics - August 20, 2020 Category: General Medicine Source Type: research

Cancer pain treatment during the COVID-19 pandemic: institutional recommendations
Rotator cuff tears are common among the elderly, and studies on the outcomes after rotator cuff repair in the elderly are limited. We carried out this meta-analysis with systematic literature search, aiming to clarify the outcomes after rotator cuff repair in the elderly as assessed by the American Shoulder and Elbow Surgeons (ASES) shoulder score. We conducted a literature search through October 2019 in PubMed and EMBASE databases and performed meta-analysis to calculate the summary mean difference comparing the post- and pre-operation ASES scores under both fixed-effect and random-effect models. Among 4978 studies identi...
Source: Clinics - August 20, 2020 Category: General Medicine Source Type: research

Bioethical principles and values during pandemics
Rotator cuff tears are common among the elderly, and studies on the outcomes after rotator cuff repair in the elderly are limited. We carried out this meta-analysis with systematic literature search, aiming to clarify the outcomes after rotator cuff repair in the elderly as assessed by the American Shoulder and Elbow Surgeons (ASES) shoulder score. We conducted a literature search through October 2019 in PubMed and EMBASE databases and performed meta-analysis to calculate the summary mean difference comparing the post- and pre-operation ASES scores under both fixed-effect and random-effect models. Among 4978 studies identi...
Source: Clinics - August 20, 2020 Category: General Medicine Source Type: research

Outcomes after rotator cuff repair in the elderly as assessed by the American Shoulder and Elbow Surgeons shoulder score
Rotator cuff tears are common among the elderly, and studies on the outcomes after rotator cuff repair in the elderly are limited. We carried out this meta-analysis with systematic literature search, aiming to clarify the outcomes after rotator cuff repair in the elderly as assessed by the American Shoulder and Elbow Surgeons (ASES) shoulder score. We conducted a literature search through October 2019 in PubMed and EMBASE databases and performed meta-analysis to calculate the summary mean difference comparing the post- and pre-operation ASES scores under both fixed-effect and random-effect models. Among 4978 studies identi...
Source: Clinics - August 20, 2020 Category: General Medicine Source Type: research

Severe clinical spectrum with high mortality in pediatric patients with COVID-19 and multisystem inflammatory syndrome
OBJECTIVES: To assess the outcomes of pediatric patients with laboratory-confirmed coronavirus disease (COVID-19) with or without multisystem inflammatory syndrome in children (MIS-C). METHODS: This cross-sectional study included 471 samples collected from 371 patients (age50 mg/L (83% vs. 25%, p=0.008) and D-dimer levels>1000 ng/mL (100% vs. 40%, p=0.007) and the median D-dimer, troponin T, and ferritin levels (p
Source: Clinics - August 20, 2020 Category: General Medicine Source Type: research

Concordance of Chest CT and Nucleic Acid Testing in Diagnosing Coronavirus Disease Outside its District of Origin (Wuhan, China)
This study aimed to determine the concordance between CT and nucleic acid testing in diagnosing coronavirus disease (COVID-19) outside its district of origin (Wuhan, China). METHODS: Twenty-three consecutive patients with COVID-19, confirmed by nucleic acid testing, were enrolled from two designated hospitals outside the district of disease origin. We collected clinical, laboratory, and CT data and assessed the concordance between CT manifestations and nucleic acid test results by comparing the percentage of patients with and without abnormal CT findings. Furthermore, using Chi-square tests, we analyzed the differences in ...
Source: Clinics - August 20, 2020 Category: General Medicine Source Type: research

microRNA-144 functions as a diagnostic and prognostic marker for retinoblastoma
CONCLUSIONS: miR-144 expression was downregulated in serum and tissue samples of RB patients and may function as a diagnostic and prognostic marker for RB. (Source: Clinics)
Source: Clinics - August 20, 2020 Category: General Medicine Source Type: research

A multidisciplinary approach to prevent and treat pressure sores in proned COVID-19 patients at a quaternary university hospital
Serologic testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) promises to assist in assessing exposure to and confirming the diagnosis of coronavirus disease 2019 (COVID-19), and to provide a roadmap for reopening countries worldwide. Considering this, a proper understanding of serologic-based diagnostic testing characteristics is critical. The aim of this study was to perform a structured systematic review and meta-analysis to evaluate the diagnostic characteristics of serological-based COVID-19 testing. Electronic searches were performed using Medline (PubMed), EMBASE, and Cochrane Library. Full-text...
Source: Clinics - August 13, 2020 Category: General Medicine Source Type: research

Diagnostic Characteristics of Serological-Based COVID-19 Testing: A Systematic Review and Meta-Analysis
Serologic testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) promises to assist in assessing exposure to and confirming the diagnosis of coronavirus disease 2019 (COVID-19), and to provide a roadmap for reopening countries worldwide. Considering this, a proper understanding of serologic-based diagnostic testing characteristics is critical. The aim of this study was to perform a structured systematic review and meta-analysis to evaluate the diagnostic characteristics of serological-based COVID-19 testing. Electronic searches were performed using Medline (PubMed), EMBASE, and Cochrane Library. Full-text...
Source: Clinics - August 13, 2020 Category: General Medicine Source Type: research

SELAdb: A database of exonic variants in a Brazilian population referred to a quaternary medical center in São Paulo
CONCLUSIONS: Currently, our database comprises a final cohort of 523 unrelated individuals, including patients or fa mily members managed by different clinics of HCFMUSP. We compared SELAdb with other publicly available genomic databases and demonstrated that this population is very heterogeneous, largely resembling Latin American individuals of mixed origin, rather than individuals of pure European ancestry. Inte restingly, exclusively through SELAdb, we identified a spectrum of known and potentially novel pathogenic variants in genes associated with highly penetrant Mendelian disorders, illustrating that pathogenic varia...
Source: Clinics - August 13, 2020 Category: General Medicine Source Type: research

Survival prognosis of newborns from an intensive care unit through the SNAP-PE II risk score
The objective of this study was to evaluate the utility of the Score for Neonatal Acute Physiology Perinatal Extension II (SNAP-PE II) score for evaluating the survival prognosis of newborns admitted to a neonatal intensive care unit (NICU). METHODS: The study design involved an observational cross-sectional retrospective collection, as well as a prospective component. The sample included all newborns admitted to the NICU validated by the SNAP-PE II tool from January 1 to December 31, 2014. RESULTS: A predominance of young mothers (25.4 years), underwent prenatal care (86.2%), however a considerable percentage (49.4%) of m...
Source: Clinics - August 13, 2020 Category: General Medicine Source Type: research

Effect of body mass index and rocuronium on serum tryptase concentration during volatile general anesthesia: an observational study
CONCLUSION: Excess weight and obesity predispose to higher preoperative serum tryptase values. Postoperative STC is not linked to rocuronium doses. BMI is the main determinant factor of STC during combined volatile general anesthesia. (Source: Clinics)
Source: Clinics - August 13, 2020 Category: General Medicine Source Type: research

Prevalence and factors associated with arterial hypertension in a Brazilian rural working population
OBJECTIVES: To determine the prevalence of hypertension and associated factors in farmers in a rural region of Brazil. METHODS: A cross-sectional study was conducted involving a sample of 790 farmers who were residents of Esp írito Santo, Brazil. RESULTS: The prevalence of hypertension was 35.8% (95%CI: 32.5-39.1%, n=283); however, it was higher in men (36.6%, n=151, p
Source: Clinics - August 13, 2020 Category: General Medicine Source Type: research

Laparoscopic surgery and coronavirus disease: What do we know now?
Questions regarding the transmissibility of the novel coronavirus disease (COVID-19) remain unanswered. It is known that the transmission of the severe acute respiratory syndrome coronavirus (SARS-CoV) occurs predominantly through droplets and contact. However, aerosols can be generated in some situations, such as orotracheal intubation, ventilation, and the use of electric or ultrasonic scalpels, and can therefore potentially contaminate the care team if adequate protection is not used. It is therefore necessary to assess issues of transmissibility of COVID-19 during surgery in infected patients. This review gathers the r...
Source: Clinics - August 4, 2020 Category: General Medicine Source Type: research

Impact of microablative fractional radiofrequency on the vaginal health, microbiota, and cellularity of postmenopausal women
We examined the cases of 55 postmenopausal women before and after treatment with regard to their vaginal health index (VHI), vaginal microbiota, vaginal pH, and cell maturation. Three applications of MAFRF were performed in the vagina/vaginal introitus. During the treatment, six vaginal smears were obtained and stained with the Papanicolaou stain for determining the degree of cell maturation and with Gram stain for classification of vaginal flora, as per the criteria of Spiegel and Amsel. For vaginal pH determination, pH indicator strips were applied against the vaginal wall. Statistical analysis was performed using SPSS f...
Source: Clinics - August 4, 2020 Category: General Medicine Source Type: research

Frailty prevalence and related factors in older adults from southern Brazil: A cross-sectional observational study
OBJECTIVES: To determine the prevalence of frailty and the association of sociodemographic characteristics, clinical aspects, and functional capacity with the frailty status of community-dwelling older adults from Curitiba, Southern Brazil. METHODS: This cross-sectional observational study included 1,716 participants aged ≥ 60 years. Frailty was assessed using the Fried phenotype indicators of weakness, exhaustion, low activity, slowness, and weight loss. Sociodemographic characteristics, clinical aspects, and functional capacity and functionality were evaluated and compared between the sexes and the different frailty s...
Source: Clinics - August 4, 2020 Category: General Medicine Source Type: research

Cross-cultural validation of the FACE-Q Satisfaction with Facial Appearance Overall Scale (FACE-Q SFAOS) in Brazilian rhytidoplasty patients
CONCLUSION: The FACE-Q SFAOS was adapted to the cultural context of Brazilian rhytidoplasty patients and was reproducible, and the scale exhibited face, content and construct validity. (Source: Clinics)
Source: Clinics - August 4, 2020 Category: General Medicine Source Type: research

Use of telemedicine to combat the COVID-19 pandemic in Brazil
(Source: Clinics)
Source: Clinics - August 4, 2020 Category: General Medicine Source Type: research

The COVID-19 pandemic: time for medical teachers and students to overcome grief
(Source: Clinics)
Source: Clinics - August 4, 2020 Category: General Medicine Source Type: research

Erratum for: Transforming operating rooms into intensive care units and the versatility of the physician anesthesiologist during the COVID-19 crisis
The coronavirus disease (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread exponentially worldwide. In Brazil, the number of infected people diagnosed has been increasing and, as in other countries, it has been associated with a high risk of contamination in healthcare teams. For healthcare professionals, the full use of personal protective equipment (PPE) is mandatory, such as wearing surgical or filtering facepiece class 2 (FFP2) masks, waterproof aprons, gloves, and goggles, in addition to training in care processes. A reduction in the number of face-to-face visits an...
Source: Clinics - July 23, 2020 Category: General Medicine Source Type: research

Virtual visits to inpatients by their loved ones during COVID-19
The coronavirus disease (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread exponentially worldwide. In Brazil, the number of infected people diagnosed has been increasing and, as in other countries, it has been associated with a high risk of contamination in healthcare teams. For healthcare professionals, the full use of personal protective equipment (PPE) is mandatory, such as wearing surgical or filtering facepiece class 2 (FFP2) masks, waterproof aprons, gloves, and goggles, in addition to training in care processes. A reduction in the number of face-to-face visits an...
Source: Clinics - July 23, 2020 Category: General Medicine Source Type: research

Evaluation of the accuracy of mammography, ultrasound and magnetic resonance imaging in suspect breast lesions
CONCLUSION: Thus, MRI and MMG were more accurate in evaluating suspicious breast lumps. MRI had a low specificity, mainly to high breast density, while MMG had also sensitivity limited due to high breast density and USG has been proven to be useful in these patients. (Source: Clinics)
Source: Clinics - July 23, 2020 Category: General Medicine Source Type: research