Transcranial direct-current stimulation protects against cerebral ischemia-reperfusion injury through regulating Cezanne-dependent signaling
Exp Neurol. 2021 Jul 26:113818. doi: 10.1016/j.expneurol.2021.113818. Online ahead of print.ABSTRACTTranscranial direct-current stimulation (tDCS) is proved safe and shows therapeutic effect in cerebral ischemic stroke in clinical trials. But the underlying molecular mechanisms remain unclear. Here we show that tDCS treatment reduces the infarct volume after rat cerebral ischemia-reperfusion (I/R) injury and results in functional improvement of stroke animals. At the cellular and molecular level, tDCS suppresses I/R-induced upregulation of Cezanne in the ischemic neurons. Cezanne inhibition confers neuroprotection after ra...
Source: Experimental Neurology - July 29, 2021 Category: Neurology Authors: Jing Cheng Yan-Qin Fan Hong-Xiang Jiang Song-Feng Chen Juan Chen Xin-Yu Liao Ying-Ying Zou Hai-Yang Lan Yu Cui Zhi-Biao Chen Qian-Xue Chen Qi Wan Source Type: research

Availability of neuregulin-1beta1 protects neurons in spinal cord injury and against glutamate toxicity through caspase dependent and independent mechanisms
Exp Neurol. 2021 Jul 24:113817. doi: 10.1016/j.expneurol.2021.113817. Online ahead of print.ABSTRACTSpinal cord injury (SCI) causes sensorimotor and autonomic impairment that partly reflects extensive, permanent loss of neurons at the epicenter and penumbra of the injury. Strategies aimed at enhancing neuronal protection are critical to attenuate neurodegeneration and improve neurological recovery after SCI. In rat SCI, we previously uncovered that the tissue levels of neuregulin-1beta 1 (Nrg-1β1) are acutely and persistently downregulated in the injured spinal cord. Nrg-1β1 is well-known for its critical roles i...
Source: Experimental Neurology - July 27, 2021 Category: Neurology Authors: Narjes Shahsavani Arsalan Alizadeh Hardeep Kataria Soheila Karimi-Abdolrezaee Source Type: research

Availability of neuregulin-1beta1 protects neurons in spinal cord injury and against glutamate toxicity through caspase dependent and independent mechanisms
Exp Neurol. 2021 Jul 24:113817. doi: 10.1016/j.expneurol.2021.113817. Online ahead of print.ABSTRACTSpinal cord injury (SCI) causes sensorimotor and autonomic impairment that partly reflects extensive, permanent loss of neurons at the epicenter and penumbra of the injury. Strategies aimed at enhancing neuronal protection are critical to attenuate neurodegeneration and improve neurological recovery after SCI. In rat SCI, we previously uncovered that the tissue levels of neuregulin-1beta 1 (Nrg-1β1) are acutely and persistently downregulated in the injured spinal cord. Nrg-1β1 is well-known for its critical roles i...
Source: Experimental Neurology - July 27, 2021 Category: Neurology Authors: Narjes Shahsavani Arsalan Alizadeh Hardeep Kataria Soheila Karimi-Abdolrezaee Source Type: research

Availability of neuregulin-1beta1 protects neurons in spinal cord injury and against glutamate toxicity through caspase dependent and independent mechanisms
Exp Neurol. 2021 Jul 24:113817. doi: 10.1016/j.expneurol.2021.113817. Online ahead of print.ABSTRACTSpinal cord injury (SCI) causes sensorimotor and autonomic impairment that partly reflects extensive, permanent loss of neurons at the epicenter and penumbra of the injury. Strategies aimed at enhancing neuronal protection are critical to attenuate neurodegeneration and improve neurological recovery after SCI. In rat SCI, we previously uncovered that the tissue levels of neuregulin-1beta 1 (Nrg-1β1) are acutely and persistently downregulated in the injured spinal cord. Nrg-1β1 is well-known for its critical roles i...
Source: Experimental Neurology - July 27, 2021 Category: Neurology Authors: Narjes Shahsavani Arsalan Alizadeh Hardeep Kataria Soheila Karimi-Abdolrezaee Source Type: research

Transcriptome analysis using patient iPSC-derived skeletal myocytes: Bet1L as a new molecule possibly linked to neuromuscular degeneration in ALS
Exp Neurol. 2021 Jul 23:113815. doi: 10.1016/j.expneurol.2021.113815. Online ahead of print.ABSTRACTAmyotrophic lateral sclerosis (ALS) is a fatal neuromuscular disease in which patients gradually become paralyzed due to loss of motor function. Many genetically inheritable mutations have been linked to ALS; however, the majority of ALS patients are considered sporadic. Therefore, there is a need for a common therapy that is effective for all ALS patients. Although there is evidence of the disease beginning in the periphery at the neuromuscular junction (NMJ), the specific processes involved in skeletal muscle and at the NM...
Source: Experimental Neurology - July 26, 2021 Category: Neurology Authors: Eileen M Lynch Samantha Robertson Claire FitzGibbons Megan Reilly Colton Switalski Adam Eckardt Sin-Ruow Tey Koji Hayakawa Masatoshi Suzuki Source Type: research

Delayed dosing of minocycline plus N-acetylcysteine reduces neurodegeneration in distal brain regions and restores spatial memory after experimental traumatic brain injury
Exp Neurol. 2021 Jul 23:113816. doi: 10.1016/j.expneurol.2021.113816. Online ahead of print.ABSTRACTMultiple drugs to treat traumatic brain injury (TBI) have failed clinical trials. Most drugs lose efficacy as the time interval increases between injury and treatment onset. Insufficient therapeutic time window is a major reason underlying failure in clinical trials. Few drugs have been developed with therapeutic time windows sufficiently long enough to treat TBI because little is known about which brain functions can be targeted if therapy is delayed hours to days after injury. We identified multiple injury parameters that ...
Source: Experimental Neurology - July 26, 2021 Category: Neurology Authors: Kristen Whitney Elena Nikulina Syed N Rahman Alisia Alexis Peter J Bergold Source Type: research

Parkin-deficient rats are resistant to neurotoxicity of chronic high-dose methamphetamine
This study used 3-month-old homozygous parkin knockout (PKO) rats to determine whether loss of parkin protein potentiates neurotoxicity of chronic METH to the nigrostriatal dopamine pathway. PKO rats were chronically treated with 10 mg/kg METH for 10 consecutive days and assessed for neurotoxicity markers in the striatum on the 5th and 10th day of withdrawal from METH. The PKO rats showed higher METH-induced hyperthermia; however, they did not display augmented deficits in dopaminergic and serotonergic neurotoxicity markers, astrocyte activation or decreased mitochondrial enzyme levels as compared to wild-type (WT) rats. I...
Source: Experimental Neurology - July 23, 2021 Category: Neurology Authors: Akhil Sharma Viktoriia Bazylianska Anna Moszczynska Source Type: research

Parkin-deficient rats are resistant to neurotoxicity of chronic high-dose methamphetamine
This study used 3-month-old homozygous parkin knockout (PKO) rats to determine whether loss of parkin protein potentiates neurotoxicity of chronic METH to the nigrostriatal dopamine pathway. PKO rats were chronically treated with 10 mg/kg METH for 10 consecutive days and assessed for neurotoxicity markers in the striatum on the 5th and 10th day of withdrawal from METH. The PKO rats showed higher METH-induced hyperthermia; however, they did not display augmented deficits in dopaminergic and serotonergic neurotoxicity markers, astrocyte activation or decreased mitochondrial enzyme levels as compared to wild-type (WT) rats. I...
Source: Experimental Neurology - July 23, 2021 Category: Neurology Authors: Akhil Sharma Viktoriia Bazylianska Anna Moszczynska Source Type: research

Parkin-deficient rats are resistant to neurotoxicity of chronic high-dose methamphetamine
This study used 3-month-old homozygous parkin knockout (PKO) rats to determine whether loss of parkin protein potentiates neurotoxicity of chronic METH to the nigrostriatal dopamine pathway. PKO rats were chronically treated with 10 mg/kg METH for 10 consecutive days and assessed for neurotoxicity markers in the striatum on the 5th and 10th day of withdrawal from METH. The PKO rats showed higher METH-induced hyperthermia; however, they did not display augmented deficits in dopaminergic and serotonergic neurotoxicity markers, astrocyte activation or decreased mitochondrial enzyme levels as compared to wild-type (WT) rats. I...
Source: Experimental Neurology - July 23, 2021 Category: Neurology Authors: Akhil Sharma Viktoriia Bazylianska Anna Moszczynska Source Type: research

Thyroid hormones during the perinatal period are necessary to respiratory network development of newborn rats
Exp Neurol. 2021 Jul 17:113813. doi: 10.1016/j.expneurol.2021.113813. Online ahead of print.ABSTRACTThyroid hormones (THs) are essential for foetal brain development. Because the gestating mother is the main source of THs to the foetus, maternal hypothyroidism and/or premature birth compromise neurological outcomes in the offspring. Respiratory instability and recurrent apneas due to immaturity of the respiratory control network are major causes of morbidity in infants. Inadequate TH supply may be sufficient to delay perinatal maturation of the respiratory control system; however, this hypothesis remains untested. To addre...
Source: Experimental Neurology - July 20, 2021 Category: Neurology Authors: Jean-Philippe Rousseau Luana Tenorio-Lopes Sergio Cortez Ghio Pascale Desjardins St éphanie Fournier Richard Kinkead Source Type: research

Thyroid hormones during the perinatal period are necessary to respiratory network development of newborn rats
Exp Neurol. 2021 Jul 17:113813. doi: 10.1016/j.expneurol.2021.113813. Online ahead of print.ABSTRACTThyroid hormones (THs) are essential for foetal brain development. Because the gestating mother is the main source of THs to the foetus, maternal hypothyroidism and/or premature birth compromise neurological outcomes in the offspring. Respiratory instability and recurrent apneas due to immaturity of the respiratory control network are major causes of morbidity in infants. Inadequate TH supply may be sufficient to delay perinatal maturation of the respiratory control system; however, this hypothesis remains untested. To addre...
Source: Experimental Neurology - July 20, 2021 Category: Neurology Authors: Jean-Philippe Rousseau Luana Tenorio-Lopes Sergio Cortez Ghio Pascale Desjardins St éphanie Fournier Richard Kinkead Source Type: research

Thyroid hormones during the perinatal period are necessary to respiratory network development of newborn rats
Exp Neurol. 2021 Jul 17:113813. doi: 10.1016/j.expneurol.2021.113813. Online ahead of print.ABSTRACTThyroid hormones (THs) are essential for foetal brain development. Because the gestating mother is the main source of THs to the foetus, maternal hypothyroidism and/or premature birth compromise neurological outcomes in the offspring. Respiratory instability and recurrent apneas due to immaturity of the respiratory control network are major causes of morbidity in infants. Inadequate TH supply may be sufficient to delay perinatal maturation of the respiratory control system; however, this hypothesis remains untested. To addre...
Source: Experimental Neurology - July 20, 2021 Category: Neurology Authors: Jean-Philippe Rousseau Luana Tenorio-Lopes Sergio Cortez Ghio Pascale Desjardins St éphanie Fournier Richard Kinkead Source Type: research

Thyroid hormones during the perinatal period are necessary to respiratory network development of newborn rats
Exp Neurol. 2021 Jul 17:113813. doi: 10.1016/j.expneurol.2021.113813. Online ahead of print.ABSTRACTThyroid hormones (THs) are essential for foetal brain development. Because the gestating mother is the main source of THs to the foetus, maternal hypothyroidism and/or premature birth compromise neurological outcomes in the offspring. Respiratory instability and recurrent apneas due to immaturity of the respiratory control network are major causes of morbidity in infants. Inadequate TH supply may be sufficient to delay perinatal maturation of the respiratory control system; however, this hypothesis remains untested. To addre...
Source: Experimental Neurology - July 20, 2021 Category: Neurology Authors: Jean-Philippe Rousseau Luana Tenorio-Lopes Sergio Cortez Ghio Pascale Desjardins St éphanie Fournier Richard Kinkead Source Type: research

MiR-375-3p mediates reduced pineal function in hypoxia-ischemia brain damage
Exp Neurol. 2021 Jul 16:113814. doi: 10.1016/j.expneurol.2021.113814. Online ahead of print.ABSTRACTThe functional roles of microRNAs (miRNAs) have been studied in various diseases, including hypoxic-ischemic brain damage (HIBD). However, changes in the expression of miRNAs and the underlying mechanisms in the pineal gland during HIBD remain unknown. Based on the previous study by microRNA array, hundreds of miRNAs showed altered expression patterns in the pineal gland in a rat model of HIBD. MiR-375-3p was found to be significantly upregulated and abundant in the pineal gland. Further investigation in an in vitro HI model...
Source: Experimental Neurology - July 19, 2021 Category: Neurology Authors: Lixiao Xu Gen Li Xiaojuan Tang Chenxi Feng Mei Li Xiaolu Jiang Yan Gu Yajing Yun Lianghua Lu Xing Feng Xin Ding Bin Sun Source Type: research

Dysregulated CRTC1-BDNF signaling pathway in the hippocampus contributes to A β oligomer-induced long-term synaptic plasticity and memory impairment
In this study, electrophysiological recordings indicated that lentivirus-mediated CRTC1 overexpression effectively ameliorates suppression of late-phase long-term potentiation (L-LTP) in rat hippocampal slices treated with oligomeric amyloid β(1-42) peptides (oAβ42) (200 nM). In addition, application of oAβ42 and genetic knockdown of CRTC1 by lentivirus-mediated CRTC1-shRNA inhibits L-LTP, whereas their combination does not further impair L-LTP. Brain-derived neurotrophic factor (BDNF), an important downstream protein confers protection of CRTC1 overexpression against oAβ42-induced L-LTP impairment as s...
Source: Experimental Neurology - July 18, 2021 Category: Neurology Authors: Peiyun Yan Zhancheng Xue Dezhu Li Saiqi Ni Chuang Wang Xinchun Jin Dongsheng Zhou Xingxing Li Xin Zhao Xiaowei Chen Wei Cui Dingli Xu Wenhua Zhou Junfang Zhang Source Type: research

Dysregulated CRTC1-BDNF signaling pathway in the hippocampus contributes to A β oligomer-induced long-term synaptic plasticity and memory impairment
In this study, electrophysiological recordings indicated that lentivirus-mediated CRTC1 overexpression effectively ameliorates suppression of late-phase long-term potentiation (L-LTP) in rat hippocampal slices treated with oligomeric amyloid β(1-42) peptides (oAβ42) (200 nM). In addition, application of oAβ42 and genetic knockdown of CRTC1 by lentivirus-mediated CRTC1-shRNA inhibits L-LTP, whereas their combination does not further impair L-LTP. Brain-derived neurotrophic factor (BDNF), an important downstream protein confers protection of CRTC1 overexpression against oAβ42-induced L-LTP impairment as s...
Source: Experimental Neurology - July 18, 2021 Category: Neurology Authors: Peiyun Yan Zhancheng Xue Dezhu Li Saiqi Ni Chuang Wang Xinchun Jin Dongsheng Zhou Xingxing Li Xin Zhao Xiaowei Chen Wei Cui Dingli Xu Wenhua Zhou Junfang Zhang Source Type: research

Memantine exerts neuroprotective effects by modulating α-synuclein transmission in a parkinsonian model
Exp Neurol. 2021 Jul 13:113810. doi: 10.1016/j.expneurol.2021.113810. Online ahead of print.ABSTRACTAmple evidence has demonstrated that α-Synuclein can propagate from one area of the brain to others via cell-to-cell transmission, which might be the underlying mechanism for pathological propagation and the disease progression of Parkinson's disease (PD). Recent reports have demonstrated cell surface receptor-mediated cell-to-cell transmission of α-synuclein. Memantine decreased the levels of internalized cytosolic α-synuclein and led to attenuation in α-synuclein-induced cell death. Specifically, me...
Source: Experimental Neurology - July 16, 2021 Category: Neurology Authors: Ji Eun Lee Ha Na Kim Dong-Yeol Kim Yu Jin Shin Jin Young Shin Phil Hyu Lee Source Type: research

Memantine exerts neuroprotective effects by modulating α-synuclein transmission in a parkinsonian model
Exp Neurol. 2021 Jul 13:113810. doi: 10.1016/j.expneurol.2021.113810. Online ahead of print.ABSTRACTAmple evidence has demonstrated that α-Synuclein can propagate from one area of the brain to others via cell-to-cell transmission, which might be the underlying mechanism for pathological propagation and the disease progression of Parkinson's disease (PD). Recent reports have demonstrated cell surface receptor-mediated cell-to-cell transmission of α-synuclein. Memantine decreased the levels of internalized cytosolic α-synuclein and led to attenuation in α-synuclein-induced cell death. Specifically, me...
Source: Experimental Neurology - July 16, 2021 Category: Neurology Authors: Ji Eun Lee Ha Na Kim Dong-Yeol Kim Yu Jin Shin Jin Young Shin Phil Hyu Lee Source Type: research

Levo-tetrahydropalmatine: A new potential medication for methamphetamine addiction and neurotoxicity
Exp Neurol. 2021 Jul 10:113809. doi: 10.1016/j.expneurol.2021.113809. Online ahead of print.ABSTRACTLevo-tetrahydropalmatine (l-THP) is mainly derived from the dried tuber of the Papaveraceae plant Corydalis, also called Corydalis B, which is a drug with analgesic, hypnotic, sedative and other effects. Methamphetamine (METH) belongs to the central nervous stimulant and is a highly addictive drug. It is an urgent problem to study the mechanism of methamphetamine neurotoxicity and to search for the therapeutic targets of the METH addiction. This review is aimed to discuss the pharmacological mechanism and the protective effe...
Source: Experimental Neurology - July 13, 2021 Category: Neurology Authors: Lian Liu Ming Liu Wei Zhao Yuan-Ling Zhao Yun Wang Source Type: research

Targeted disruption to NMDA receptor dependent synaptic plasticity in area CA1 of the hippocampus
Exp Neurol. 2021 Jul 10:113808. doi: 10.1016/j.expneurol.2021.113808. Online ahead of print.ABSTRACTChanged NMDA receptor (NMDAr) physiology is implicated with cognitive deficit resulting from conditions ranging from normal aging to neurological disease. Using intermittent hypoxia (IH) to experimentally model untreated sleep apnea, a clinical condition whose comorbidities include neurocognitive impairment, we recently demonstrated that IH causes a pro-oxidant condition that contributes to deficits in spatial memory and in NMDAr-dependent long-term potentiation (LTP). However, the impact of IH on additional forms of synapti...
Source: Experimental Neurology - July 13, 2021 Category: Neurology Authors: Alejandra Arias-Cavieres Ateh Fonteh Carolina I Castro-Rivera Alfredo J Garcia Source Type: research

Levo-tetrahydropalmatine: A new potential medication for methamphetamine addiction and neurotoxicity
Exp Neurol. 2021 Jul 10:113809. doi: 10.1016/j.expneurol.2021.113809. Online ahead of print.ABSTRACTLevo-tetrahydropalmatine (l-THP) is mainly derived from the dried tuber of the Papaveraceae plant Corydalis, also called Corydalis B, which is a drug with analgesic, hypnotic, sedative and other effects. Methamphetamine (METH) belongs to the central nervous stimulant and is a highly addictive drug. It is an urgent problem to study the mechanism of methamphetamine neurotoxicity and to search for the therapeutic targets of the METH addiction. This review is aimed to discuss the pharmacological mechanism and the protective effe...
Source: Experimental Neurology - July 13, 2021 Category: Neurology Authors: Lian Liu Ming Liu Wei Zhao Yuan-Ling Zhao Yun Wang Source Type: research

Targeted disruption to NMDA receptor dependent synaptic plasticity in area CA1 of the hippocampus
Exp Neurol. 2021 Jul 10:113808. doi: 10.1016/j.expneurol.2021.113808. Online ahead of print.ABSTRACTChanged NMDA receptor (NMDAr) physiology is implicated with cognitive deficit resulting from conditions ranging from normal aging to neurological disease. Using intermittent hypoxia (IH) to experimentally model untreated sleep apnea, a clinical condition whose comorbidities include neurocognitive impairment, we recently demonstrated that IH causes a pro-oxidant condition that contributes to deficits in spatial memory and in NMDAr-dependent long-term potentiation (LTP). However, the impact of IH on additional forms of synapti...
Source: Experimental Neurology - July 13, 2021 Category: Neurology Authors: Alejandra Arias-Cavieres Ateh Fonteh Carolina I Castro-Rivera Alfredo J Garcia Source Type: research

Altered corticostriatal synchronization associated with compulsive-like behavior in APP/PS1 mice
Exp Neurol. 2021 Jul 7;344:113805. doi: 10.1016/j.expneurol.2021.113805. Online ahead of print.ABSTRACTMild behavioral impairment (MBI), which can include compulsive behavior, is an early sign of Alzheimer's disease (AD), but its underlying neural mechanisms remain unclear. Here, we show that 3-5-month-old APP/PS1 mice display obsessive-compulsive disorder (OCD)-like behavior. The number of parvalbumin-positive (PV) interneurons and level of high gamma (γhigh) oscillation are significantly decreased in the striatum of AD mice. This is accompanied by enhanced β-γhigh coupling and firing rates of putative st...
Source: Experimental Neurology - July 9, 2021 Category: Neurology Authors: Yi-Gang Peng Ping-Jing Cai Jian-Hang Hu Jin-Xiang Jiang Jia-Jia Zhang Ke-Fang Liu Li Yang Cheng Long Source Type: research

Altered corticostriatal synchronization associated with compulsive-like behavior in APP/PS1 mice
Exp Neurol. 2021 Jul 6:113805. doi: 10.1016/j.expneurol.2021.113805. Online ahead of print.ABSTRACTMild behavioral impairment (MBI), which can include compulsive behavior, is an early sign of Alzheimer's disease (AD), but its underlying neural mechanisms remain unclear. Here, we show that 3-5-month-old APP/PS1 mice display obsessive-compulsive disorder (OCD)-like behavior. The number of parvalbumin-positive (PV) interneurons and level of high gamma (γhigh) oscillation are significantly decreased in the striatum of AD mice. This is accompanied by enhanced β-γhigh coupling and firing rates of putative striat...
Source: Experimental Neurology - July 9, 2021 Category: Neurology Authors: Yi-Gang Peng Ping-Jing Cai Jian-Hang Hu Jin-Xiang Jiang Jia-Jia Zhang Ke-Fang Liu Li Yang Cheng Long Source Type: research

Altered corticostriatal synchronization associated with compulsive-like behavior in APP/PS1 mice
Exp Neurol. 2021 Jul 6:113805. doi: 10.1016/j.expneurol.2021.113805. Online ahead of print.ABSTRACTMild behavioral impairment (MBI), which can include compulsive behavior, is an early sign of Alzheimer's disease (AD), but its underlying neural mechanisms remain unclear. Here, we show that 3-5-month-old APP/PS1 mice display obsessive-compulsive disorder (OCD)-like behavior. The number of parvalbumin-positive (PV) interneurons and level of high gamma (γhigh) oscillation are significantly decreased in the striatum of AD mice. This is accompanied by enhanced β-γhigh coupling and firing rates of putative striat...
Source: Experimental Neurology - July 9, 2021 Category: Neurology Authors: Yi-Gang Peng Ping-Jing Cai Jian-Hang Hu Jin-Xiang Jiang Jia-Jia Zhang Ke-Fang Liu Li Yang Cheng Long Source Type: research

Altered corticostriatal synchronization associated with compulsive-like behavior in APP/PS1 mice
Exp Neurol. 2021 Jul 6:113805. doi: 10.1016/j.expneurol.2021.113805. Online ahead of print.ABSTRACTMild behavioral impairment (MBI), which can include compulsive behavior, is an early sign of Alzheimer's disease (AD), but its underlying neural mechanisms remain unclear. Here, we show that 3-5-month-old APP/PS1 mice display obsessive-compulsive disorder (OCD)-like behavior. The number of parvalbumin-positive (PV) interneurons and level of high gamma (γhigh) oscillation are significantly decreased in the striatum of AD mice. This is accompanied by enhanced β-γhigh coupling and firing rates of putative striat...
Source: Experimental Neurology - July 9, 2021 Category: Neurology Authors: Yi-Gang Peng Ping-Jing Cai Jian-Hang Hu Jin-Xiang Jiang Jia-Jia Zhang Ke-Fang Liu Li Yang Cheng Long Source Type: research

Targeting platelet glycoprotein VI attenuates progressive ischemic brain damage before recanalization during middle cerebral artery occlusion in mice
In conclusion, our experimental data support ongoing clinical trials blocking platelet GPVI in acute ischemic stroke.PMID:34237320 | DOI:10.1016/j.expneurol.2021.113804 (Source: Experimental Neurology)
Source: Experimental Neurology - July 8, 2021 Category: Neurology Authors: Michael Bieber Michael K Schuhmann Alexander M Kollikowski David Stegner Bernhard Nieswandt Mirko Pham Guido Stoll Source Type: research

Targeting platelet glycoprotein VI attenuates progressive ischemic brain damage before recanalization during middle cerebral artery occlusion in mice
In conclusion, our experimental data support ongoing clinical trials blocking platelet GPVI in acute ischemic stroke.PMID:34237320 | DOI:10.1016/j.expneurol.2021.113804 (Source: Experimental Neurology)
Source: Experimental Neurology - July 8, 2021 Category: Neurology Authors: Michael Bieber Michael K Schuhmann Alexander M Kollikowski David Stegner Bernhard Nieswandt Mirko Pham Guido Stoll Source Type: research

Ambulatory assessment for precision psychiatry: Foundations, current developments and future avenues
Exp Neurol. 2021 Jul 3:113807. doi: 10.1016/j.expneurol.2021.113807. Online ahead of print.ABSTRACTPrecision psychiatry stands to benefit from the latest digital technologies for assessment and analyses to tailor treatment towards individuals. Insights into dynamic psychological processes as they unfold in humans' everyday life can critically add value in understanding symptomatology and environmental stressors to provide individualized treatment where and when needed. Towards this goal, ambulatory assessment encompasses methodological approaches to investigate behavioral, physiological, and biological processes in humans'...
Source: Experimental Neurology - July 6, 2021 Category: Neurology Authors: Markus Reichert Gabriela Gan Malika Renz Urs Braun Sarah Br üßler Irina Timm Ren Ma Oksana Berhe Anastasia Benedyk Alexander Moldavski Janina I Schweiger Oliver Hennig Francesca Zidda Christine Heim Tobias Banaschewski Heike Tost Ulrich W Ebner-Priemer Source Type: research

The protective effect and potential mechanism of NRXN1 on learning and memory in ADHD rat models
Exp Neurol. 2021 Jul 3:113806. doi: 10.1016/j.expneurol.2021.113806. Online ahead of print.ABSTRACTThe learning and memory network is highly complex and remains unclear. The hippocampus is the location of learning and memory function. Impairment of synaptic morphology and synaptic plasticity (i.e., long-term potentiation) appears to cause learning and memory deficits. Several studies have indicated the role of NRXN1 in regulating the synaptic function, but little is known on its role in learning and memory dysfunction associated with attention deficit and hyperactivity disorder (ADHD). Our results showed that overexpressio...
Source: Experimental Neurology - July 6, 2021 Category: Neurology Authors: Sufen Zhang Di Wu Qu Xu Lianghui You Jiansheng Zhu Jingyu Wang Zhonghui Liu Lei Yang Meiling Tong Qin Hong Xia Chi Source Type: research

Ambulatory assessment for precision psychiatry: Foundations, current developments and future avenues
Exp Neurol. 2021 Jul 3:113807. doi: 10.1016/j.expneurol.2021.113807. Online ahead of print.ABSTRACTPrecision psychiatry stands to benefit from the latest digital technologies for assessment and analyses to tailor treatment towards individuals. Insights into dynamic psychological processes as they unfold in humans' everyday life can critically add value in understanding symptomatology and environmental stressors to provide individualized treatment where and when needed. Towards this goal, ambulatory assessment encompasses methodological approaches to investigate behavioral, physiological, and biological processes in humans'...
Source: Experimental Neurology - July 6, 2021 Category: Neurology Authors: Markus Reichert Gabriela Gan Malika Renz Urs Braun Sarah Br üßler Irina Timm Ren Ma Oksana Berhe Anastasia Benedyk Alexander Moldavski Janina I Schweiger Oliver Hennig Francesca Zidda Christine Heim Tobias Banaschewski Heike Tost Ulrich W Ebner-Priemer Source Type: research

The protective effect and potential mechanism of NRXN1 on learning and memory in ADHD rat models
Exp Neurol. 2021 Jul 3:113806. doi: 10.1016/j.expneurol.2021.113806. Online ahead of print.ABSTRACTThe learning and memory network is highly complex and remains unclear. The hippocampus is the location of learning and memory function. Impairment of synaptic morphology and synaptic plasticity (i.e., long-term potentiation) appears to cause learning and memory deficits. Several studies have indicated the role of NRXN1 in regulating the synaptic function, but little is known on its role in learning and memory dysfunction associated with attention deficit and hyperactivity disorder (ADHD). Our results showed that overexpressio...
Source: Experimental Neurology - July 6, 2021 Category: Neurology Authors: Sufen Zhang Di Wu Qu Xu Lianghui You Jiansheng Zhu Jingyu Wang Zhonghui Liu Lei Yang Meiling Tong Qin Hong Xia Chi Source Type: research

Ethanol's disruptive effects upon early breathing plasticity and blood parameters associated with hypoxia and hypercapnia
Exp Neurol. 2021 Jul 2:113796. doi: 10.1016/j.expneurol.2021.113796. Online ahead of print.ABSTRACTEarly ethanol exposure affects respiratory neuroplasticity; a risk factor associated with the Sudden Infant Death Syndrome. High and chronic ethanol doses exert long-lasting effects upon respiratory rates, apneic episodes and ventilatory processes triggered by hypoxia. The present study was performed in 3-9-day-old rat pups. Respiratory processes under normoxic and hypoxic conditions were analyzed in pups intoxicated with different ethanol doses which were pre-exposed or not to the drug. A second major goal was to examine if ...
Source: Experimental Neurology - July 5, 2021 Category: Neurology Authors: Florencia Anunziata Ana F Macchione Asier Angulo Alcalde David N Tejerina Jos é L Amigone Aranza Wille-Bille Ver ónica Trujillo Juan C Molina Source Type: research

Ethanol's disruptive effects upon early breathing plasticity and blood parameters associated with hypoxia and hypercapnia
Exp Neurol. 2021 Jul 2:113796. doi: 10.1016/j.expneurol.2021.113796. Online ahead of print.ABSTRACTEarly ethanol exposure affects respiratory neuroplasticity; a risk factor associated with the Sudden Infant Death Syndrome. High and chronic ethanol doses exert long-lasting effects upon respiratory rates, apneic episodes and ventilatory processes triggered by hypoxia. The present study was performed in 3-9-day-old rat pups. Respiratory processes under normoxic and hypoxic conditions were analyzed in pups intoxicated with different ethanol doses which were pre-exposed or not to the drug. A second major goal was to examine if ...
Source: Experimental Neurology - July 5, 2021 Category: Neurology Authors: Florencia Anunziata Ana F Macchione Asier Angulo Alcalde David N Tejerina Jos é L Amigone Aranza Wille-Bille Ver ónica Trujillo Juan C Molina Source Type: research

Corrigendum to "Acute treatment with TrkB agonist LM22A-4 confers neuroprotection and preserves myelin integrity in a mouse model of pediatric traumatic brain injury" [Experimental Neurology 339 (2021): 113652]
Exp Neurol. 2021 Jun 26:113790. doi: 10.1016/j.expneurol.2021.113790. Online ahead of print.NO ABSTRACTPMID:34187696 | DOI:10.1016/j.expneurol.2021.113790 (Source: Experimental Neurology)
Source: Experimental Neurology - June 30, 2021 Category: Neurology Authors: Jessica L Fletcher Larissa K Dill Rhiannon J Wood Sharon Wang Kate Robertson Simon S Murray Akram Zamani Bridgette D Semple Source Type: research

Corrigendum to "Acute treatment with TrkB agonist LM22A-4 confers neuroprotection and preserves myelin integrity in a mouse model of pediatric traumatic brain injury" [Experimental Neurology 339 (2021): 113652]
Exp Neurol. 2021 Jun 26:113790. doi: 10.1016/j.expneurol.2021.113790. Online ahead of print.NO ABSTRACTPMID:34187696 | DOI:10.1016/j.expneurol.2021.113790 (Source: Experimental Neurology)
Source: Experimental Neurology - June 30, 2021 Category: Neurology Authors: Jessica L Fletcher Larissa K Dill Rhiannon J Wood Sharon Wang Kate Robertson Simon S Murray Akram Zamani Bridgette D Semple Source Type: research

Corrigendum to "Acute treatment with TrkB agonist LM22A-4 confers neuroprotection and preserves myelin integrity in a mouse model of pediatric traumatic brain injury" [Experimental Neurology 339 (2021): 113652]
Exp Neurol. 2021 Jun 26:113790. doi: 10.1016/j.expneurol.2021.113790. Online ahead of print.NO ABSTRACTPMID:34187696 | DOI:10.1016/j.expneurol.2021.113790 (Source: Experimental Neurology)
Source: Experimental Neurology - June 30, 2021 Category: Neurology Authors: Jessica L Fletcher Larissa K Dill Rhiannon J Wood Sharon Wang Kate Robertson Simon S Murray Akram Zamani Bridgette D Semple Source Type: research

Corrigendum to "Acute treatment with TrkB agonist LM22A-4 confers neuroprotection and preserves myelin integrity in a mouse model of pediatric traumatic brain injury" [Experimental Neurology 339 (2021): 113652]
Exp Neurol. 2021 Jun 26:113790. doi: 10.1016/j.expneurol.2021.113790. Online ahead of print.NO ABSTRACTPMID:34187696 | DOI:10.1016/j.expneurol.2021.113790 (Source: Experimental Neurology)
Source: Experimental Neurology - June 30, 2021 Category: Neurology Authors: Jessica L Fletcher Larissa K Dill Rhiannon J Wood Sharon Wang Kate Robertson Simon S Murray Akram Zamani Bridgette D Semple Source Type: research

Corrigendum to "Acute treatment with TrkB agonist LM22A-4 confers neuroprotection and preserves myelin integrity in a mouse model of pediatric traumatic brain injury" [Experimental Neurology 339 (2021): 113652]
Exp Neurol. 2021 Jun 26:113790. doi: 10.1016/j.expneurol.2021.113790. Online ahead of print.NO ABSTRACTPMID:34187696 | DOI:10.1016/j.expneurol.2021.113790 (Source: Experimental Neurology)
Source: Experimental Neurology - June 30, 2021 Category: Neurology Authors: Jessica L Fletcher Larissa K Dill Rhiannon J Wood Sharon Wang Kate Robertson Simon S Murray Akram Zamani Bridgette D Semple Source Type: research

Neurotoxicity of methamphetamine: Main effects and mechanisms
Exp Neurol. 2021 Jun 26:113795. doi: 10.1016/j.expneurol.2021.113795. Online ahead of print.ABSTRACTMethamphetamine (METH) is an illicit psychostimulant that is abused throughout the world. METH addiction is also a major public health concern and the abuse of large doses of the drug is often associated with serious neuropsychiatric consequences that may include agitation, anxiety, hallucinations, paranoia, and psychosis. Some human methamphetamine users can also suffer from attention, memory, and executive deficits. METH-associated neurological and psychiatric complications might be related, in part, to METH-induced neurot...
Source: Experimental Neurology - June 29, 2021 Category: Neurology Authors: Subramaniam Jayanthi Atul P Daiwile Jean Lud Cadet Source Type: research

Agonism of the α < sub > 7 < /sub > -acetylcholine receptor/PI3K/Akt pathway promotes neuronal survival after subarachnoid hemorrhage in mice
Exp Neurol. 2021 Jun 25:113792. doi: 10.1016/j.expneurol.2021.113792. Online ahead of print.ABSTRACTSubarachnoid hemorrhage (SAH) results in severe neuronal dysfunction and degeneration. Since the nicotinic acetylcholine α7 receptors (α7-AChR) are involved in neuronal function and survival, we investigated if stimulation of α7-AChR would promote neuronal survival and improve behavioral outcome following SAH in mice. Male mice subjected to SAH were treated with either galantamine (α7-AChR agonist) or vehicle. Neurobehavioral testing was performed 24 h after SAH, and mice were euthanized for analysis ...
Source: Experimental Neurology - June 28, 2021 Category: Neurology Authors: Ari Dienel Remya A Veettil Kanako Matsumura H Alex Choi T Peeyush Kumar Andrey S Tsvetkov Jaroslaw Aronowski Pramod Dash Spiros L Blackburn Devin W McBride Source Type: research

Agonism of the α < sub > 7 < /sub > -acetylcholine receptor/PI3K/Akt pathway promotes neuronal survival after subarachnoid hemorrhage in mice
Exp Neurol. 2021 Jun 25:113792. doi: 10.1016/j.expneurol.2021.113792. Online ahead of print.ABSTRACTSubarachnoid hemorrhage (SAH) results in severe neuronal dysfunction and degeneration. Since the nicotinic acetylcholine α7 receptors (α7-AChR) are involved in neuronal function and survival, we investigated if stimulation of α7-AChR would promote neuronal survival and improve behavioral outcome following SAH in mice. Male mice subjected to SAH were treated with either galantamine (α7-AChR agonist) or vehicle. Neurobehavioral testing was performed 24 h after SAH, and mice were euthanized for analysis ...
Source: Experimental Neurology - June 28, 2021 Category: Neurology Authors: Ari Dienel Remya A Veettil Kanako Matsumura H Alex Choi T Peeyush Kumar Andrey S Tsvetkov Jaroslaw Aronowski Pramod Dash Spiros L Blackburn Devin W McBride Source Type: research

Methamphetamine and heightened risk for early-onset stroke and Parkinson's disease: A review
DISCUSSION: Methamphetamine use among young people (
Source: Experimental Neurology - June 24, 2021 Category: Neurology Authors: Julia M Lappin Shane Darke Source Type: research

Strategies to neutralize RhoA/ROCK pathway after spinal cord injury
Exp Neurol. 2021 Jun 22;343:113794. doi: 10.1016/j.expneurol.2021.113794. Online ahead of print.ABSTRACTRegeneration is bungled following CNS injuries, including spinal cord injury (SCI). Inherent decay of permissive conditions restricts the regrowth of the mature CNS after an injury. Hypertrophic scarring, insignificant intrinsic axon-growth activity, and axon-growth inhibitory molecules such as myelin inhibitors and scar inhibitors constitute a significant hindrance to spinal cord repair. Besides these molecules, a combined absence of various mechanisms responsible for axonal regeneration is the main reason behind the de...
Source: Experimental Neurology - June 24, 2021 Category: Neurology Authors: Abhishek Roy Zarna Pathak Hemant Kumar Source Type: research

Methamphetamine and heightened risk for early-onset stroke and Parkinson's disease: A review
DISCUSSION: Methamphetamine use among young people (
Source: Experimental Neurology - June 24, 2021 Category: Neurology Authors: Julia M Lappin Shane Darke Source Type: research

Strategies to neutralize RhoA/ROCK pathway after spinal cord injury
Exp Neurol. 2021 Jun 21:113794. doi: 10.1016/j.expneurol.2021.113794. Online ahead of print.ABSTRACTRegeneration is bungled following CNS injuries, including spinal cord injury (SCI). Inherent decay of permissive conditions restricts the regrowth of the mature CNS after an injury. Hypertrophic scarring, insignificant intrinsic axon-growth activity, and axon-growth inhibitory molecules such as myelin inhibitors and scar inhibitors constitute a significant hindrance to spinal cord repair. Besides these molecules, a combined absence of various mechanisms responsible for axonal regeneration is the main reason behind the dereli...
Source: Experimental Neurology - June 24, 2021 Category: Neurology Authors: Abhishek Roy Zarna Pathak Hemant Kumar Source Type: research

Methamphetamine and heightened risk for early-onset stroke and Parkinson's disease: A review
DISCUSSION: Methamphetamine use among young people (
Source: Experimental Neurology - June 24, 2021 Category: Neurology Authors: Julia M Lappin Shane Darke Source Type: research

Strategies to neutralize RhoA/ROCK pathway after spinal cord injury
Exp Neurol. 2021 Jun 21:113794. doi: 10.1016/j.expneurol.2021.113794. Online ahead of print.ABSTRACTRegeneration is bungled following CNS injuries, including spinal cord injury (SCI). Inherent decay of permissive conditions restricts the regrowth of the mature CNS after an injury. Hypertrophic scarring, insignificant intrinsic axon-growth activity, and axon-growth inhibitory molecules such as myelin inhibitors and scar inhibitors constitute a significant hindrance to spinal cord repair. Besides these molecules, a combined absence of various mechanisms responsible for axonal regeneration is the main reason behind the dereli...
Source: Experimental Neurology - June 24, 2021 Category: Neurology Authors: Abhishek Roy Zarna Pathak Hemant Kumar Source Type: research

Methamphetamine and heightened risk for early-onset stroke and Parkinson's disease: A review
DISCUSSION: Methamphetamine use among young people (
Source: Experimental Neurology - June 24, 2021 Category: Neurology Authors: Julia M Lappin Shane Darke Source Type: research

Strategies to neutralize RhoA/ROCK pathway after spinal cord injury
Exp Neurol. 2021 Jun 21:113794. doi: 10.1016/j.expneurol.2021.113794. Online ahead of print.ABSTRACTRegeneration is bungled following CNS injuries, including spinal cord injury (SCI). Inherent decay of permissive conditions restricts the regrowth of the mature CNS after an injury. Hypertrophic scarring, insignificant intrinsic axon-growth activity, and axon-growth inhibitory molecules such as myelin inhibitors and scar inhibitors constitute a significant hindrance to spinal cord repair. Besides these molecules, a combined absence of various mechanisms responsible for axonal regeneration is the main reason behind the dereli...
Source: Experimental Neurology - June 24, 2021 Category: Neurology Authors: Abhishek Roy Zarna Pathak Hemant Kumar Source Type: research