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Condition: Hypothermia

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Total 450 results found since Jan 2013.

Neurologic Complications in the Pediatric Intensive Care Unit
This article discusses an approach to the recognition and management of seizures, stroke, and cardiac arrest as complications of other critical illnesses in the pediatric intensive care unit.RECENT FINDINGSConvulsive and nonconvulsive seizures occur frequently in children after cardiac arrest or traumatic brain injury and during extracorporeal membrane oxygenation. Seizures may add to neurologic morbidity, and continuous EEG monitoring is needed for up to 24 hours for detection. Hypothermia has not been shown to improve outcome after cardiac arrest in children, but targeted temperature management with controlled normotherm...
Source: CONTINUUM: Lifelong Learning in Neurology - February 1, 2018 Category: Neurology Tags: Review Articles Source Type: research

Career perspective: Kenneth J. Collins
AbstractA career interest in thermoregulation research has included wide contrasts in the subjects of enquiry, extending from heat stroke to hypothermia, special investigations in many different purpose-built climatic chambers, laboratory-based biomedical studies together with hospital practice, and field work in tropical climates to physiological surveys on urban populations in temperate environments. The scientific process and need to focus on careful planning of experiments, using the most appropriate methods, selecting the right controls and eventually applying correct statistical analysis do not always follow a smooth...
Source: Extreme Physiology and Medicine - January 23, 2018 Category: Physiology Source Type: research

Effect and Feasibility of Therapeutic Hypothermia in Patients with Hemorrhagic Stroke: A  Systematic Review and Meta-Analysis
Therapeutic hypothermia (TH) has shown good results in experimental models of hemorrhagic stroke. The clinical application of TH, however, remains controversial, since reports regarding its therapeutic effect are inconsistent.
Source: World Neurosurgery - January 8, 2018 Category: Neurosurgery Authors: Zhong Yao, Chao You, Min He Tags: Literature Reviews Source Type: research

Effect and feasibility of therapeutic hypothermia in patients with hemorrhagic stroke: a systematic review and meta-analysis
Therapeutic hypothermia (TH) has shown a good performance in the experimental hemorrhagic stroke. But the clinical application of TH remains controversial since reports regarding its therapeutic effect are inconsistent.
Source: World Neurosurgery - January 8, 2018 Category: Neurosurgery Authors: Zhong Yao, Chao You, Min He Tags: Literature Reviews Source Type: research

Safety of Moderate Hypothermia With Antegrade Cerebral Perfusion in Total Aortic Arch Replacement.
CONCLUSIONS: In this series, TOTAL with MHCA and ACP can be safely performed with acceptable operative risk. MHCA and ACP represent an effective strategy for TOTAL and may obviate the need for DHCA. PMID: 29167026 [PubMed - indexed for MEDLINE]
Source: The Annals of Thoracic Surgery - December 28, 2017 Category: Cardiovascular & Thoracic Surgery Authors: Keeling WB, Tian DH, Leshnower BG, Numata S, Hughes GC, Matalanis G, Okita Y, Yan TD, Kouchoukos N, Chen EP, IAASSG Investigators Tags: Ann Thorac Surg Source Type: research

Safety of Moderate Hypothermia With Antegrade Cerebral Perfusion in Total Aortic Arch Replacement
Conclusions In this series, TOTAL with MHCA and ACP can be safely performed with acceptable operative risk. MHCA and ACP represent an effective strategy for TOTAL and may obviate the need for DHCA.
Source: The Annals of Thoracic Surgery - December 10, 2017 Category: Cardiovascular & Thoracic Surgery Source Type: research

Normothermia after decompressive surgery for space-occupying middle cerebral artery infarction: a protocol-based approach
Moderate hypothermia after decompressive surgery might not be beneficial for stroke patients. However, normothermia may prove to be an effective method of enhancing neurological outcomes. The study aims were t...
Source: BMC Neurology - December 4, 2017 Category: Neurology Authors: Jan Rahmig, Matthias Kuhn, Hermann Neugebauer, Eric J üttler, Heinz Reichmann and Hauke Schneider Tags: Research article Source Type: research

Statistical analysis plan for the EuroHYP-1 trial: European multicentre, randomised, phase III clinical trial of the therapeutic hypothermia plus best medical treatment versus best medical treatment alone for acute ischaemic stroke
Cooling may reduce infarct size and improve neurological outcomes in patients with ischaemic stroke. In phase II trials, cooling awake patients with ischaemic stroke has been shown to be feasible and safe, but...
Source: Trials - November 29, 2017 Category: General Medicine Authors: Per Winkel, Philip M. Bath, Christian Gluud, Jane Lindschou, H. Bart van der Worp, Malcolm R. Macleod, Istvan Szabo, Isabelle Durand-Zaleski and Stefan Schwab Tags: Update Source Type: research

A model based on the Pennes bioheat transfer equation is valid in normal brain tissue but not brain tissue suffering focal ischaemia
AbstractIschaemic stroke is a major public health issue in both developed and developing nations. Hypothermia is believed to be neuroprotective in cerebral ischaemia. Conversely, elevated brain temperature is associated with poor outcome after ischaemic stroke. Mechanisms of heat exchange in normally-perfused brain are relatively well understood, but these mechanisms have not been studied as extensively during focal cerebral ischaemia. A finite element model (FEM) of heat exchange during focal ischaemia in the human brain was developed, based on the Pennes bioheat equation. This model incorporated healthy (normally-perfuse...
Source: Australasian Physical and Engineering Sciences in Medicine - November 2, 2017 Category: Biomedical Engineering Source Type: research

Whole body perfusion strategy for aortic arch repair under moderate hypothermia.
CONCLUSIONS: A WBP strategy during aortic arch reconstruction with MHCA may be associated with more rapid normalization of metabolic parameters and reduced ICU length of stay compared to using ACP alone. Further evaluation with a randomized trial is warranted. PMID: 29103365 [PubMed - as supplied by publisher]
Source: Perfusion - November 1, 2017 Category: Cardiovascular & Thoracic Surgery Authors: Tarola CL, Losenno KL, Gelinas JJ, Jones PM, Fernandes P, Fox SA, Kiaii B, Chu MWA Tags: Perfusion Source Type: research

PD149163 induces hypothermia to protect against brain injury in acute cerebral ischemic rats
In this study, we pharmacologically induced hypothermia on Sprague Dawley rats by intraperitoneally injecting PD149163. We found that mild hypothermia was induced by PD149163 treatment without local cerebral blood flow (LCBF) alteration. To evaluate the neuroprotective effects of PD149163, TTC staining, HE staining and Nissl’s staining were performed in our study. We found that PD149163 could prevent neuronal damage, and inhibit proliferation and activation of glial cells induced by ischemia. Simultaneously, we observed PD149163 ameliorated apoptosis characterized by down-regulated caspase-3 and Bax, but elevated Bcl-2. ...
Source: Journal of Pharmacological Sciences - October 23, 2017 Category: Drugs & Pharmacology Source Type: research

The Implementation of Targeted Temperature Management: An Evidence-Based Guideline from the Neurocritical Care Society
ConclusionThis guideline is intended for neurocritical care clinicians who have chosen to use TTM in patient care; it is not meant to provide guidance regarding the clinical indications for TTM itself. While there are areas of TTM practice where clear evidence guides strong recommendations, many of the recommendations are conditional, and must be contextualized to individual patient and system needs.
Source: Neurocritical Care - October 16, 2017 Category: Neurology Source Type: research

Synergistic effect of mild hypothermia and the Notch inhibitor DAPT against post stroke seizures.
Abstract Seizure is a serious complication of stroke, indicating poor prognosis. Notch signaling is associated with neuronal activity. Inhibition of Notch signaling suppresses seizure activity induced by kainic acid. The present study investigated the effect of the Notch inhibitor, DAPT, alone or in combination with mild hypothermia, on post-stroke seizures. A global cerebral ischemia (GCI) model was performed in Sprague Dawley (SD) male rats. Seizure activity was evaluated by the frequency of seizure attacks, seizure severity scores, and seizure discharges. Without any intervention, seizures occurred intensively ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 13, 2017 Category: Drugs & Pharmacology Authors: Yang GS, Zhou XY, An XF, Liu XJ, Zhang YJ, Yu D Tags: Biomed Pharmacother Source Type: research

Pretreatment with indomethacin results in increased heat stroke severity during recovery in a rodent model of heat stroke
It has been suggested that medications can increase heat stroke (HS) susceptibility/severity. We investigated whether the nonsteroidal anti-inflammatory drug (NSAID) indomethacin (INDO) increases HS severity in a rodent model. Core temperature (Tc) of male, C57BL/6J mice (n = 45) was monitored continuously, and mice were given a dose of INDO [low dose (LO) 1 mg/kg or high dose (HI) 5 mg/kg in flavored treat] or vehicle (flavored treat) before heating. HS animals were heated to 42.4°C and euthanized at three time points for histological, molecular, and metabolic analysis: onset of HS [maximal core temperature (Tc,Max)],...
Source: Journal of Applied Physiology - September 6, 2017 Category: Physiology Authors: Audet, G. N., Dineen, S. M., Stewart, D. A., Plamper, M. L., Pathmasiri, W. W., McRitchie, S. L., Sumner, S. J., Leon, L. R. Tags: RESEARCH ARTICLE Source Type: research