Filtered By:
Condition: Hypothermia

This page shows you your search results in order of date. This is page number 9.

Order by Relevance | Date

Total 450 results found since Jan 2013.

Single-Stage Treatment of Extensive Aortic Pathology Using the Frozen Elephant Trunk Procedure.
CONCLUSION: The frozen elephant trunk procedure can be used for a single-stage treatment of patients with extensive aortic pathology, due to chronic degenerative aneurysms or post-dissection aneurysms involving the aortic arch and the descending aorta, with acceptable mortality and morbidity. PMID: 32990581 [PubMed - as supplied by publisher]
Source: The Heart Surgery Forum - August 27, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Risteski P, Papestiev V, Hadzievska S, Mehmedovic N, Lazovski N, Zimbakov Z, Filipce V, Shokarovski M Tags: Heart Surg Forum Source Type: research

Drug development in targeting ion channels for brain edema.
Abstract Cerebral edema is a pathological hallmark of various central nervous system (CNS) insults, including traumatic brain injury (TBI) and excitotoxic injury such as stroke. Due to the rigidity of the skull, edema-induced increase of intracranial fluid significantly complicates severe CNS injuries by raising intracranial pressure and compromising perfusion. Mortality due to cerebral edema is high. With mortality rates up to 80% in severe cases of stroke, it is the leading cause of death within the first week. Similarly, cerebral edema is devastating for patients of TBI, accounting for up to 50% mortality. Curr...
Source: Acta Pharmacologica Sinica - August 26, 2020 Category: Drugs & Pharmacology Authors: Luo ZW, Ovcjak A, Wong R, Yang BX, Feng ZP, Sun HS Tags: Acta Pharmacol Sin Source Type: research

Continuous cerebral and myocardial selective perfusion in neonatal aortic arch surgery
ConclusionCCMSP is a safe and reproducible strategy for cerebral, myocardial and visceral protection in neonatal aortic arch repair, with or without VSD closure, resulting in low complication and mortality.
Source: Journal of Cardiac Surgery - August 12, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Pierre Maminirina, Carine Pavy, Pierre Bourgoin, Olivier Baron Tags: ORIGINAL ARTICLE Source Type: research

Reperfusion plus Selective Intra-arterial Cooling (SI-AC) Improve Recovery in a Nonhuman Primate Model of Stroke
AbstractEarly reperfusion is increasingly prioritized in ischemic stroke care, but outcomes remain suboptimal. Therefore, there is an urgent need to find neuroprotective approaches that can be combined with reperfusion to maximize efficacy. Here, the neuroprotective mechanisms behind therapeutic hypothermia were evaluated in a monkey model of ischemic stroke. Focal ischemia was induced in adult rhesus monkeys by placing autologous clots in the middle cerebral artery. Monkeys were treated with tissue plasminogen activator (t-PA) alone or t-PA plus selective intra-arterial cooling (SI-AC). Serial MRI scans and functional def...
Source: Neurotherapeutics - July 23, 2020 Category: Neurology Source Type: research

Hypothermia treatment reduced cyclin-dependent kinase 5-mediated inflammation in ischemic stroke and improved outcomes in ischemic stroke patients
The coronavirus disease (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread exponentially worldwide. In Brazil, the number of infected people diagnosed has been increasing and, as in other countries, it has been associated with a high risk of contamination in healthcare teams. For healthcare professionals, the full use of personal protective equipment (PPE) is mandatory, such as wearing surgical or filtering facepiece class 2 (FFP2) masks, waterproof aprons, gloves, and goggles, in addition to training in care processes. A reduction in the number of face-to-face visits an...
Source: Clinics - July 11, 2020 Category: General Medicine Source Type: research

Therapeutic Hypothermia in Critically Ill Patients: A Systematic Review and Meta-Analysis of High Quality Randomized Trials*
Conclusions: High-quality randomized evidence indicates that therapeutic hypothermia is associated with higher mortality and no difference in good neurologic outcome compared with normothermia in critically ill patients. Although there still might be a possibility that therapeutic hypothermia is beneficial in a specific setting, routine application of therapeutic hypothermia would better be avoided outside the settings indicated by international guidelines (adult cardiac arrest and hypoxic-ischemic encephalopathy of newborns).
Source: Critical Care Medicine - June 20, 2020 Category: Emergency Medicine Tags: Review Articles Source Type: research

IJERPH, Vol. 17, Pages 4082: Nutrition-Related Adverse Outcomes in Endurance Sports Competitions: A Review of Incidence and Practical Recommendations
Conclusions: The main adverse outcomes in endurance and ultra-endurance sports modalities are EAH, GI inconveniences, and EHS. These problems can affect the performance and health status of the athlete during and post-competition. Several nutritional guidelines have been suggested that can prevent these adverse outcomes, and it is essential to individualize and adjust the nutritional intake and hydration status according to the characteristics of each competition.
Source: International Journal of Environmental Research and Public Health - June 7, 2020 Category: Environmental Health Authors: Jos é Miguel Martínez-Sanz Ana Fern ández Nuñez Isabel Sospedra Alejandro Mart ínez-Rodríguez Ra úl Domínguez Jos é Antonio González-Jurado Antonio J. S ánchez-Oliver Tags: Review Source Type: research

Safety of Triple Neuroprotection with Targeted Hypothermia, Controlled Induced Hypertension, and Barbiturate Infusion during Emergency Carotid Endarterectomy for Acute Stroke after Missing the 24  Hours Window Opportunity
The aim of this study is to establish the initial safety of triple neuroprotection (TNP) in an acute stroke setting in patients presenting outside the window for systemic tissue plasminogen activator (tPA).
Source: Annals of Vascular Surgery - May 26, 2020 Category: Surgery Authors: Sherif Sultan, Makinderjit Dulai, John Laffey, Kevin Clarkson, Abdelaly M.A. Abedi, Nora Barrett, Mohamed Elsherif, Wael Tawfick, Niamh Hynes Tags: Clinical Research Source Type: research

Safety of Triple Neuroprotection with targeted hypothermia, controlled induced hypertension and barbiturate infusion during emergency carotid endarterectomy for acute stroke after missing the 24 hours window opportunity.
and Purpose: Our study aims to establish the initial safety of triple neuroprotection (TNP) in an acute stroke setting in patients presenting outside the window for systemic tissue plasminogen activator (tPA).
Source: Annals of Vascular Surgery - May 26, 2020 Category: Surgery Authors: Sherif Sultan, Makinderjit Dulai, John Laffey, Kevin Clarkson, Abdelaly MA. Abedi, Nora Barrett, Mohamed Elsherif, Wael Tawfick, Niamh Hynes Tags: Clinical Research, Basic Science Source Type: research

The Future of Therapeutic Hypothermia for Stroke The Future of Therapeutic Hypothermia for Stroke
Renewed interest and recent data suggest that hypothermia may be neuroprotective in patients suffering from stroke.Medscape Neurology
Source: Medscape Neurology and Neurosurgery Headlines - May 22, 2020 Category: Neurology Tags: Neurology & Neurosurgery Expert Column Source Type: news

Intra-arterial neuroprotective therapy as an adjunct to endovascular intervention in acute ischemic stroke: A review of the literature and future directions.
Authors: Link TW, Santillan A, Patsalides A Abstract Mechanical thrombectomy for acute ischemic stroke due to large vessel occlusion has been shown to significantly improve outcomes. However, despite efficient rates of recanalization (60-90%), the rates of functional independence remain suboptimal (14-58%), most likely due to pathways of cell death in the brain that have already committed despite successful reperfusion. Pharmacologic neuroprotection provides a potential means of preventing this inevitable damage through targeting excitotoxicity, reactive oxygen species, cellular apoptosis, and inflammation. Numerou...
Source: Interventional Neuroradiology - May 21, 2020 Category: Radiology Tags: Interv Neuroradiol Source Type: research

Therapeutic Hypothermia in Acute Ischemic Stroke —a Systematic Review and Meta-Analysis
AbstractPurpose of ReviewTherapeutic hypothermia (TH) in stroke demonstrates robust neuroprotection in animals but clinical applications remain controversial. We assessed current literature on the efficacy of TH in ischemic stroke.Recent FindingsWe conducted a meta-analysis comparing TH versus controls in studies published until June 2019. Controlled studies reporting on ≥ 10 adults with acute ischemic stroke were included. Primary outcome was functional independence (modified Rankin Scale [mRS] ≤ 2). Twelve studies (n = 351 TH,n = 427 controls) were included. Functional independence did not differ between ...
Source: Current Neurology and Neuroscience Reports - May 4, 2020 Category: Neuroscience Source Type: research

Cerebral blood flow velocity and oxygenation correlate predominantly with right ventricular function in cooled neonates with moderate-severe hypoxic-ischemic encephalopathy
Conclusion: CBF velocity and brain oxygenation correlate predominantly with RV function in HIE  + TH. This suggests a preferential contribution of RV performance to cerebral hemodynamics in this context.What is Known:• Neonates with hypoxic ischemic encephalopathy frequently exhibit alterations of cardiac function and cerebral blood flow.• These are considered organ-specific consequences of perinatal asphyxia.What is New:• We show that cerebral blood flow velocity and brain oxygenation are correlated predominantly with right ventricular function during therapeutic hypothermia.• This suggests a potential direct ...
Source: European Journal of Pediatrics - May 3, 2020 Category: Pediatrics Source Type: research

Therapeutic Hypothermia Protects Against Heat Stroke-Induced Arterial Hypotension via Promoting Left Ventricular Performance in Rats.
Authors: Ko WC, Lin CH, Lee JJ, Chang CP, Chao CM Abstract We aimed to ascertain whether therapeutic hypothermia (TH) acts as cardioprotective management for heat stroke (HS). Adult male rats under general anesthesia were exposed to whole-body heating (43°C for 70 min) to induce HS. Rats with HS displayed hyperthermia (core body temperature 42°C vs. 36°C); hypotension (30 mmHg vs. 90 mmHg mean arterial blood pressure); suppressed left ventricular (LV) performance (stroke volume 52 μl/min vs. 125 μl/min), ejection fraction (0.29% vs. 0.69%), relaxation factor (72 ms vs. 12 ms), and arterial elastance (0.31 mmHg...
Source: International Journal of Medical Sciences - March 18, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Whole body hypothermia extends tissue plasminogen activator treatment window in the rat model of embolic stroke
Publication date: Available online 20 February 2020Source: Life SciencesAuthor(s): Mahsa Hassanipour, Mohammadreza Zarisfi, Vahid Ehsani, Mohammad AllahtavakoliAbstractLate treatment with tissue plasminogen activator (tPA) leads to reperfusion injury and poor outcome in ischemic stroke. We have recently shown the beneficial effects of local brain hypothermia after late thrombolysis. Herein, we investigated whether transient whole-body hypothermia was neuroprotective and could prevent the side effects of late tPA therapy at 5.5 h after embolic stroke. After induction of stroke, male rats were randomly assigned into four g...
Source: Life Sciences - February 20, 2020 Category: Biology Source Type: research