Could automated analysis of chest X-rays detect early bronchiectasis in children?
Conclusion: Regional abnormalities can be detected by digital analysis of CXR, which may provide a low-cost and readily available tool to indicate the need for diagnostic CT and for ongoing disease monitoring.What is Known:• Bronchiectasis is a severe chronic respiratory disorder increasingly recognised in paediatric populations.• Diagnostic computed tomography imaging is often requested only after several chest X-ray investigations.What is New:• We show that a digital analysis of chest X-ray could provide more accurate identification of bronchiectasis features. (Source: European Journal of Pediatrics)
Source: European Journal of Pediatrics - September 9, 2021 Category: Pediatrics Source Type: research

Aortic valve surgery: management and outcomes in the paediatric population
Conclusion: In this review, we aim to outline the various surgical options and discuss efficacy and complications of various interventions.What is Known:•Congenital aortic valve defects repair options medically and surgicallyWhat is New:•Comparisons between surgical options for aortic valve repair including efficacy, risks and long-term outcomes. (Source: European Journal of Pediatrics)
Source: European Journal of Pediatrics - September 9, 2021 Category: Pediatrics Source Type: research

Bisphenol A and its effects on the systemic organs of children
Conclusion: Evidence from in vitro and animal studies may provide further support and better understanding on the correlation between environmental BPA exposure and its detrimental effects in humans and child development, despite the difficulties to draw direct causal relations of BPA effects on the pathophysiology of the diseases/syndromes in children, due to differences in body system complexity between children and adults, as well as between animal and in vitro models and humans.What is known:• Very limited reviews are available on how BPA adversely affects children’s health.• Previous papers mainly cove...
Source: European Journal of Pediatrics - September 9, 2021 Category: Pediatrics Source Type: research

Low technology, mild controlled hypothermia for necrotizing enterocolitis treatment: an initiative to improve healthcare to preterm neonates.
Conclusions: In our experience, low technology, mild controlled hypothermia was feasible, not related to adverse effects, and effective treatment for NEC Modified Bell ’s Stage II/III. It avoided surgery, bowel perforation, and extensive intestinal resection; reduced mortality; and shortened parenteral nutrition duration.What is Known:• New approaches have been proposed to avoid enterocolitis incidence; however, the treatment of enterocolitis stage 2 has been the same for decades, and unfavourable outcomes remain despite conventional management.• Studies suggest that hypothermia can be an alternative to ent...
Source: European Journal of Pediatrics - September 9, 2021 Category: Pediatrics Source Type: research

Association of maternal folate use and reduced folate carrier gene polymorphisms with the risk of congenital heart disease in offspring
Conclusion: In those of Chinese descent, maternal folate use and the time when use started are significantly associated with the risk of CHD in offspring. Furthermore, maternal folate supplementation may help to offset some of the risks of CHD in offspring due to maternalRFC1 genetic variants.What is Known:• Folate use could help prevent CHD, but the relationship between the time when folate use is started and CHD has not received sufficient attention.• Studies have assessed the associations of folate metabolism-related genes with CHD, but genes involved in cellular transportation of folate, such as the RFC1 gene...
Source: European Journal of Pediatrics - September 9, 2021 Category: Pediatrics Source Type: research

Screening of COVID-19 in outpatient children with cancer or solid organ transplantation: preliminary report
Conclusion: Seroprevalence of SARS-CoV-2 infection is high among immunosuppressed children and adolescents. COVID-19 has a mild or asymptomatic course in most of these patients.What is Known:• The number of immunosuppressed patients with coronavirus disease 2019 is increasing.• Viral infections have the potential for greater severity in immunocompromised children.What is New:• Seroprevalence for severe acute respiratory syndrome coronavirus 2 in immunocompromised pediatric patients was 31%.• A quarter of the serology-positive patients reported mild symptoms and none of them developed multisystem inflamm...
Source: European Journal of Pediatrics - September 9, 2021 Category: Pediatrics Source Type: research

Nasal HFOV versus nasal IPPV as a post-extubation respiratory support in preterm infants —a randomised controlled trial
Conclusion: Extubation failure within 72 h in infants less than 37 weeks of gestation did not differ between the two groups. However, nHFOV seems promising in reducing enteral feeding issues and pCO2 elimination. Larger multicentre studies are required for exploring benefits of nHFOV.Trial registration:www.ctri.nic.in id CTRI/2019/07/020055, registration date July 5, 2019What is Known:• NIPPV is superior to nCPAP as a secondary mode of respiratory support.• Synchronisation is preferred for optimum ventilation.What is New:• nHFOV, a novel non-invasive respiratory modality without need for synchronisation, app...
Source: European Journal of Pediatrics - September 9, 2021 Category: Pediatrics Source Type: research

Bedside sonographic assessments for predicting predialysis fluid overload in children with end-stage kidney disease
Conclusion:  Randomized controlled studies are needed to prove the reliability of the combined use of lung ultrasounds and cIVC in the assessment of predialysis fluid overload.What is Known:• The association of chronic fluid overload with increased morbidity and mortality raises the need for optimal determination of fluid overload in pediatric patients who are dialysis-dependent at a young age.• The linear correlation between the total number of B-lines on lung ultrasound images and fluid overload by weight has been shown.What is New:• This study evaluates the lung ultrasound and inferior vena cava coll...
Source: European Journal of Pediatrics - September 9, 2021 Category: Pediatrics Source Type: research

Osteoperiostitis in children: proposal for a diagnostic algorithm
Conclusion: We propose a diagnostic algorithm, based on simple clinical data, which can help guide a prompt and appropriate diagnosis of JOP.What is Known:• Juvenile osteoperiostitis (JOP) are a group of inflammatory bone diseases followed by various pediatric specialists.• The distinction between these conditions is not easy as clinical and laboratory features often overlap.What is New:• We propose a diagnostic algorithm, based on clinical data of real patients, with high degree accuracy.• This instrument can help guide the prompt and appropriate diagnosis of JOP. (Source: European Journal of Pediatrics)
Source: European Journal of Pediatrics - September 9, 2021 Category: Pediatrics Source Type: research

Infective endocarditis in paediatric population
Conclusion: Over the past decades, there have been great advancements in clinical practice to improve outcomes in patients with infective endocarditis. Nonetheless, further work is required to better investigative and manage such high risk cohort.What is Known:• The current diagnostic techniques including ‘Duke’s criteria’ for paediatric infective endocarditis diagnosis• The current management guidelines utilised for paediatric infective endocarditisWhat is New:• The long-term outcomes of patients that underwent medical and surgical intervention• The quality of life of paediatric patie...
Source: European Journal of Pediatrics - September 9, 2021 Category: Pediatrics Source Type: research

Burden of respiratory syncytial virus bronchiolitis on the Dutch pediatric intensive care units
AbstractRespiratory syncytial virus (RSV) bronchiolitis causes substantial morbidity and mortality in young children, but insight into the burden of RSV bronchiolitis on pediatric intensive care units (PICUs) is limited. We aimed to determine the burden of RSV bronchiolitis on the PICUs in the Netherlands. Therefore, we identified all children ≤ 24 months of age with RSV bronchiolitis between 2003 and 2016 from a nationwide PICU registry. Subsequently we manually checked their patient records for correct diagnosis and collected patient characteristics, additional clinical data, respiratory support modes, and outcome. In...
Source: European Journal of Pediatrics - September 9, 2021 Category: Pediatrics Source Type: research

Optimal administration of bronchodilators with valved holding chambers in preschool children: a review of literature
AbstractOur aim was to synthesize the published literature on factors that potentially affect the delivery of bronchodilators using valved holding chambers (VHC) in preschool children. We also aimed to identify those attributes that are not yet incorporated or clearly stated in the guidelines and those topics that are still lacking sufficient data. There is strong evidence supporting several recommendations in current guidelines. Based on present knowledge, bronchodilators should be delivered by VHC administering each puff separately. Face mask should be omitted as soon as the child can hold the mouthpiece of the VHC tight...
Source: European Journal of Pediatrics - September 9, 2021 Category: Pediatrics Source Type: research

Diagnosis and management of precocious sexual maturation: an updated review
Conclusion: The aim of this review is to address the epidemiology, etiology, clinical assessment, and management of precocious sexual maturation.What is Known:• The main sign to suspect the onset of puberty is breast tissue development (thelarche) in girls and testicular enlargement (≥4 mL) in boys. The classic definition of precocious sexual maturation is the development of secondary sexual characteristics before 8 years of age in girls and before 9 years of age in boys.• Long-acting gonadotropin-releasing hormone agonist (GnRHa) is the standard of care for CPP management, and adequate hormone suppression res...
Source: European Journal of Pediatrics - September 9, 2021 Category: Pediatrics Source Type: research

Clinical characteristics of children affected by autism spectrum disorder with and without generalized hypotonia
AbstractIn this cross-sectional study, we aimed to evaluate the association between generalized hypotonia (GH) and demographic features and clinical characteristics in toddlers (2 to 5 years) with autism spectrum disorder (ASD). Among 93 children, 32 (34.4%) had GH. These patients had a later onset of independent walking (17 vs. 15 months,p
Source: European Journal of Pediatrics - September 9, 2021 Category: Pediatrics Source Type: research

Correction to: Assessment of anti-infective medication adherence in pediatric outpatients
A Correction to this paper has been published:https://doi.org/10.1007/s00431-021-04027-w (Source: European Journal of Pediatrics)
Source: European Journal of Pediatrics - September 9, 2021 Category: Pediatrics Source Type: research

Comment on “COVID-19 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children and adolescents: a systematic review of critically unwell children and the association with underlying comorbidities”
(Source: European Journal of Pediatrics)
Source: European Journal of Pediatrics - September 9, 2021 Category: Pediatrics Source Type: research

Red blood cell distribution width and tumor necrosis factor- α for the early prediction of coronary artery lesion in Kawasaki disease: a retrospective study
AbstractWe aimed to identify novel risk factors for the early prediction of coronary artery lesion (CAL) in children with Kawasaki disease (KD). We retrospectively analyzed data from hospitalized children newly diagnosed with KD between January 1, 2018, and December 31, 2020, with the following inclusion criteria: (1) diagnosis of KD, (2) first onset of CAL after admission, (3) with complete clinical records. Demographic and laboratory data were collected and analyzed. The independent risk factors of KD combined with CAL were identified by multivariate logistic regression analysis, followed by receiver operating characteri...
Source: European Journal of Pediatrics - September 7, 2021 Category: Pediatrics Source Type: research

Feasibility of portable capnometer for mechanically ventilated preterm infants in the delivery room
This study aimed to determine whether a specific portable capnometer (EMMA ™) can facilitate the maintenance of an appropriate partial pressure of arterial carbon dioxide (PaCO2) in intubated preterm infants in the delivery room. This study included preterm infants with a gestational age of 26  + 0 to 31 + 6 weeks who required intubation in the delivery room. We prospectively identified 40 infants who underwent the EMMA™ monitoring intervention group and 43 infants who did not undergo monitoring (historical control group). PaCO2 was evaluated either at admission in the neonatal ...
Source: European Journal of Pediatrics - September 7, 2021 Category: Pediatrics Source Type: research

Correction to: COVID ‑19 in children: clinical and epidemiological spectrum in the community
(Source: European Journal of Pediatrics)
Source: European Journal of Pediatrics - September 7, 2021 Category: Pediatrics Source Type: research

COVID-19 pandemic in the neonatal intensive care unit: any effect on late-onset sepsis and necrotizing enterocolitis?
Conclusion: COVID-19-related implementation of NICU hygiene policies is likely to reduce the occurrence of LOS in high-risk settings.What is Known:• COVID-19 pandemic has disrupted routine care in Neonatal Intensive Care Units (NICUs), mostly by tightening infection control measures and restricting parental presence in the NICU.• Beyond the described psychological impact of COVID-19 related measures on healthcare workers and NICU families, their consequences in terms of preterm infants’ clinical outcomes have not been described in detail yet.What is New:• Strengthened infection-control measures do not ...
Source: European Journal of Pediatrics - September 6, 2021 Category: Pediatrics Source Type: research

Role of environmental surfaces and hands of healthcare workers in perpetuating multi-drug-resistant pathogens in a neonatal intensive care unit
Conclusion: The hands of HCWs, crash carts and incubators are reservoirs of pathogens and can lead to nosocomial infections. Clusters of multi-drug-resistantKlebsiella pneumoniae andCandida spp. were the predominant neonatal pathogens in this NICU.What is Known:• The role of hands and the environment in transmission of infections to neonates is a subject of debate.• Genetic sequencing provides solid evidence for detecting homologous strains.What is New:• K. pneumoniae was the most frequently isolated pathogen, and concomitant isolation was found in two cases from the neonatal surroundings (bed/incubator) and...
Source: European Journal of Pediatrics - September 6, 2021 Category: Pediatrics Source Type: research

Inequality in place-of-death among children: a Danish nationwide study
Conclusions: The fact that household income was not associated with dying at home may be explained by the Danish tax-financed healthcare system. However, having haematological cancers, non-cancerous conditions or being an immigrant were associated with lower odds for home death. Cultural differences along with heterogeneous trajectories may partly explain these differences, which should be considered prospectively.What is Known:• Prior studies have shown disparities in place-of-death of terminally ill children with diagnosis, ethnicity and socio-economic position as key factors.• Danish healthcare is tax-financed...
Source: European Journal of Pediatrics - September 4, 2021 Category: Pediatrics Source Type: research

Child suicides in Sweden, 2000 –2018
AbstractAlthough child mortality is decreasing in Sweden, an increase in suicide rates has been previously observed among children and adolescents collectively. To increase knowledge about trends, demographics, and means in child suicides, data including all child (
Source: European Journal of Pediatrics - September 2, 2021 Category: Pediatrics Source Type: research

Effectiveness of Pelargonium sidoides in pediatric patients diagnosed with uncomplicated upper respiratory tract infection: a single-blind, randomized, placebo-controlled study
Conclusion: The findings of the study revealed that thePelargonium sidoides extracts are effective in relieving the symptom burden in the duration of the disease. It may be regarded as an alternative option for the management of URTIs.What is Known:• Upper respiratory tract infections (URTIs), an inflammation on the upper airways, are the most common infectious disease in children.• Pelargonium sidoides, a traditional medicinal plant native to South Africa, is one of the ornamental geraniums that is thought to be effective in treating URTIsWhat is New:• It may be revealed that the dried root extract of Pelar...
Source: European Journal of Pediatrics - August 7, 2021 Category: Pediatrics Source Type: research

Association between genetic variations in carbamoyl-phosphate synthetase gene and persistent neonatal pulmonary hypertension
Conclusion: We concluded that mutant CPS-I A/C rs4399666 minor variant especially the homozygous CC genotype is frequently distributed among the PPHN group. This demonstrates that the presence of mutant CPS-I rs4399666 does not necessarily predispose to the development of PPHN in neonates, but nonetheless, if the C allele is inherited in the homozygous CC genotype, it is associated with a higher risk of PPHN.What is Known:•Prior studies found that polymorphisms in urea cycle enzyme genes are associated with PPHN.•Association between CPS-1 gene polymorphisms is significantly associated with PPHN.What is New:•...
Source: European Journal of Pediatrics - August 7, 2021 Category: Pediatrics Source Type: research

Optimising insulin aspart practices in a neonatal intensive care unit: a clinical and pharmaco-technical study
Conclusion: The revision of the insulin therapy protocol reduced the variability of insulin concentration in preparations and avoided the administration of glycated derivatives potentially toxic for neonates.What is Known:• Insulin preparation in NICUs is a risky task because it is a two-step preparation• Diluted in dextrose, insulin aspart is unstable, with formation of potentially toxic glycated derivativesWhat is New:• This work proposes a new insulin therapy protocol validated by HPLC-UV for NICU allowing suppression of the formation of glycated insulin, to significantly reduce deviations from theoretica...
Source: European Journal of Pediatrics - August 7, 2021 Category: Pediatrics Source Type: research

Risk factors for dermatological complications of anti-TNF therapy in a cohort of children with Crohn ’s disease
Conclusion: The frequency of skin complications seems high in paediatric CD patients treated with anti-TNF and is even higher in those treated with infliximab.What is Known:•The dermatologic complications occur during treatment with anti-tumour necrosis factor.•The frequency of skin complications in paediatric patients with Crohn’s disease is high.What is New:•Infliximab (vs. adalimumab) was identified as a strong risk factor for the cumulative incidence of skin complications.•Lower C-reactive protein levels were associated with the current occurrence of dermatologic complications. (Source: Europe...
Source: European Journal of Pediatrics - August 7, 2021 Category: Pediatrics Source Type: research

Vaccine hesitancy and reported non-vaccination in an Irish pediatric outpatient population
AbstractVaccine hesitancy is defined as a delay in acceptance, or refusal, of vaccines, despite availability. It is a complex and context specific phenomenon and identified as a global health priority. The “Parent Attitudes about Childhood Vaccines” (PACV) questionnaire is a validated tool for identifying vaccine hesitancy. Our aim was to use the PACV to assess vaccine hesitancy and its relationship with reported non-vaccination in an Irish population, for the first time. Our participants were par ents or caregivers of children attending general pediatric clinics in a tertiary pediatric hospital in Dublin, Irel...
Source: European Journal of Pediatrics - August 7, 2021 Category: Pediatrics Source Type: research

From dyad to triad: a survey on fathers ’ knowledge and attitudes toward breastfeeding
Conclusion: By using a novel instrument aimed at quantifying fathers ’ knowledge and overall attitude toward breastfeeding, this study underlines the importance of including fathers in the promotion of breastfeeding. Expanding the classic mother-baby dyad to a more modern mother-father-baby triad may impact breastfeeding outcomes at discharge.What is known:• Social support plays a major role in improving breastfeeding outcomes.• Fathers may greatly influence initiation and duration of breastfeeding; the more they know, the more helpful they can be.What is new:• A multidisciplinary team created a struct...
Source: European Journal of Pediatrics - August 7, 2021 Category: Pediatrics Source Type: research

Z-score is a possible predictor of the risk of coronary artery lesion development in patients with Kawasaki disease in Japan
AbstractRisk factors for coronary artery lesion (CAL) development in patients with Kawasaki disease (KD) include male sex, age
Source: European Journal of Pediatrics - August 7, 2021 Category: Pediatrics Source Type: research

Is quantitative ultrasound a measure for metabolic bone disease in preterm-born infants? A prospective subcohort study
In this study, we aimed to (a) evaluate postnatal changes in bone development in relation to growth and (b) to determine factors associated with bone development, from birth to 24 months of corrected age. The metacarpal speed of sound (mcSOS) and metacarpal bone transmission time (mcBTT) were used to evaluate bone development in 98 preterm infants, during hospitalization and follow-up. The mcSOS and mcBTT values not only declined in the first 6 weeks of hospitalization but also during follow-up. The mcSOS reached its lowest point at 12 months (β=-34.64), while the mcBTT reached a plateau between 12 and 24 months (&bet...
Source: European Journal of Pediatrics - August 7, 2021 Category: Pediatrics Source Type: research

The influence of chest X-ray results on antibiotic prescription for childhood pneumonia in the emergency department
Conclusion: Performance of CXR was independently associated with more antibiotic prescription, regardless of its results. The limited influence of CXR results on antibiotic prescription highlights the inferior role of CXR on treatment decisions for suspected lower RTI in the ED.What is Known:• Chest X-ray (CXR) has a high inter-observer variability and cannot distinguish between bacterial or viral pneumonia.• Current guidelines recommend against routine use of CXR in children with uncomplicated respiratory tract infections (RTIs) in the outpatient setting.What is New:• CXR is still frequently performed in no...
Source: European Journal of Pediatrics - August 7, 2021 Category: Pediatrics Source Type: research

Association of assisted reproductive technology with autism spectrum disorder in the offspring: an updated systematic review and meta-analysis
This study aims to provide an up-to-date meta-analysis of data from studies investigating the risk of bearing a child with autism spectrum disorder (ASD) after being conceived by assisted reproductive technology (ART). The study was conducted according to the PRISMA Statement. PubMed and Scopus databases were searched up to August 2, 2020. Observational studies using a type of conception of assisted reproductive technology and examined as outcome offspring with ASD were included. A random effect model was applied due to the heterogeneity of the studies. Statistical analysis was performed with Stata 13 software. The Newcast...
Source: European Journal of Pediatrics - August 7, 2021 Category: Pediatrics Source Type: research

Consensus statements on the information to deliver after a febrile seizure
Conclusion: We propose key messages to be communicated with families in the post-FS clinic setting.What is Known:• Febrile seizures (FS) are traumatic events for families.• No guidelines exist on what information to share with parents following a FS.What is New:• A Delphi process involving child neurologists and pediatricians provides consensual statement about information to deliver after a febrile seizure.• We propose key messages to be communicated with families in the post-FS clinic setting. (Source: European Journal of Pediatrics)
Source: European Journal of Pediatrics - August 7, 2021 Category: Pediatrics Source Type: research

Universal neonatal foot orthotics —a novel treatment of infantile metatarsus adductus
Conclusion: UNFO is an effective treatment for moderate and severe MTA in children younger than10 months, with only infrequent minor side effects.What is Known:•Debate exists as to which patient warrants treatment since spontaneous improvement is the rule. However, some deformities persist to adulthood and may be esthetically unpleasing.•Treatment modalities available vary from benign neglect, special shoe ware that are either static or need special tools, and knowledge to adjust or casting by an orthopedic surgeonWhat is New:•This is a description of the results of treatment with a new orthotics which may b...
Source: European Journal of Pediatrics - August 7, 2021 Category: Pediatrics Source Type: research

Early impact of school closure and social distancing for COVID-19 on the number of inpatients with childhood non-COVID-19 acute infections in Japan
AbstractMany countries have implemented school closures as part of social distancing measures intended to control the spread of coronavirus disease 2019 (COVID-19). The aim of this study was to assess the early impact of nationwide school closure (March –May 2020) and social distancing for COVID-19 on the number of inpatients with major childhood infectious diseases in Japan. Using data from the Diagnosis Procedure Combination system in Japan, we identified patients aged 15 years or younger with admissions for a diagnosis of upper respiratory tra ct infection (URTI), lower respiratory tract infection (LRTI), influenz...
Source: European Journal of Pediatrics - August 7, 2021 Category: Pediatrics Source Type: research

Integrated oral care contributes positively to the course of treatment of oncopediatric patients
Conclusion: The permanent oral health care to offer to oncopediatric patients increased surveillance regarding oral comorbidities and reduced chemotherapy interruptions due to severe oral mucositis. This care plan could be adopted anywhere around the world.What is Known:• Several studies on oral care for pediatric oncology patients, especially regarding both prevention of and treatment for oral mucositis during antineoplastic therapy, have been published.What is New:• This study describes the benefits of permanent oral care with daily oral surveillance for pediatric patients, which reduced the duration of severe ...
Source: European Journal of Pediatrics - August 7, 2021 Category: Pediatrics Source Type: research

Correction to: Safety and effectiveness of vedolizumab in paediatric patients with inflammatory bowel disease: an observational multicenter Spanish study
A correction to this paper has been published:https://doi.org/10.1007/s00431-021-04117-9 (Source: European Journal of Pediatrics)
Source: European Journal of Pediatrics - August 7, 2021 Category: Pediatrics Source Type: research

Some variables to discuss regarding vesicoureteral reflux management
(Source: European Journal of Pediatrics)
Source: European Journal of Pediatrics - August 6, 2021 Category: Pediatrics Source Type: research

Letter to the Editor on the original article “Effectiveness and risks of endoscopic management compared to vesicoureteral reimplantation in patients with high-grade vesicoureteral reflux: systematic review and network meta-analysis”
(Source: European Journal of Pediatrics)
Source: European Journal of Pediatrics - August 6, 2021 Category: Pediatrics Source Type: research

Maternal SARS-CoV-2 infection during pregnancy: possible impact on the infant
Conclusion: The repeated occurrence of mother-to-child transmission in our cohort with risks that remain incompletely understood, such as long-term effects and the possibility of an embryopathy, should sensitize researchers and stimulate further studies as well as support COVID-19 vaccination recommendations for pregnant women.Trial registration number: NCT04741412. Date of registration: November 18, 2020What is Known:•Materno-fetal transmission of severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) during pregnancy has rarely been reported so far, but was demonstrated in isolated cases.What is New:•In a...
Source: European Journal of Pediatrics - August 5, 2021 Category: Pediatrics Source Type: research

Evaluation of immunization status in patients with cerebral palsy: a multicenter CP-VACC study
This study aims to examine age-appropriate immunization status and related factors in the CP population of our country. This cross-sectional prospective multicentered survey study included 18 pediatric neurology clinics around Turkey, wherein outpatient children with CP were included in the study. Data on patient and CP characteristics, concomitant disorders, vaccination status included in the National Immunization Program (NIP), administration, and influenza vaccine recommendation were collected at a single visit. A total of 1194 patients were enrolled. Regarding immunization records, the most frequently administrated and...
Source: European Journal of Pediatrics - August 5, 2021 Category: Pediatrics Source Type: research

The effect of exchange transfusion on mortality in neonatal sepsis: a meta-analysis
Conclusion: Currently, the use of ET in neonatal sepsis is not directly recommended due to low certainty of evidence, inadequate power and moderate –high risk of bias and heterogeneity.Trial registration: PROSPERO (CRD42020176629) (https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=176629)What is Known:• Exchange transfusion is one of the adjunctive methods for treatment of neonatal sepsis.What is New:• The pooled analysis of all studies shows that exchange transfusion has a low certainty of evidence in the context of neonatal mortality. However, at this point, this intervention cannot be refut...
Source: European Journal of Pediatrics - August 5, 2021 Category: Pediatrics Source Type: research

Congenital anomalies and genetic disorders in neonates and infants: a single-center observational cohort study
Conclusions: Genetic disorders were suspected in 13% of the cohort, but only confirmed in 5%. Most received their genetic diagnosis in the post-neonatal period. Extrapolation of the diagnostic yield suggests that up to 6% of our cohort may have remained genetically undiagnosed. Our data show the need to improve genetic care in the NICU for more inclusive, earlier, and faster genetic diagnosis to enable tailored management.What is Known:• Genetic disorders are suspected in many neonates but only genetically confirmed in a minority.• The presence of a genetic disorder can be easily missed and will often lead to a d...
Source: European Journal of Pediatrics - August 4, 2021 Category: Pediatrics Source Type: research

More on SARS-COV-2 infection in children and newborns
(Source: European Journal of Pediatrics)
Source: European Journal of Pediatrics - August 3, 2021 Category: Pediatrics Source Type: research

Proadrenomedullin and neonatal sepsis: a systematic review and meta-analysis of diagnostic accuracy
AbstractThe association of proadrenomedullin and neonatal sepsis has been examined in numerous studies. The object of our meta-analysis is to evaluate differences in proadrenomedullin among neonates with sepsis and health neonates. We systematically searched the following databases: MEDLINE, Clinicaltrials.gov, Cochrane Central Register of Controlled Trials (CENTRAL), Google Scholar, and WHO (International Clinical Trials Register Platform) using a structured algorithm. Statistical analysis was conducted using Revman 5.3 and R software. Included studies in the meta-analysis were assessed using the Newcastle –Ottawa s...
Source: European Journal of Pediatrics - August 3, 2021 Category: Pediatrics Source Type: research

Efficacy of transcutaneous bilirubinometry as compared to serum bilirubin in preterm newborn during phototherapy
Conclusion: TcB measurements from the covered skin area in jaundiced preterm infants during phototherapy were not correlated with TsB and cannot be used as an alternate of serum bilirubin testing.What is known•HPLC bilirubin measurement is a gold standard test for bilirubin measurement but impractical for day to day use. Serum total bilirubin is used for clinical testing..•There is evidence for use of transcutaneous bilirubinometry for assessment of bilirubin in term newborn.What is new•TcB measurements from a covered skin area in jaundiced preterm newborns under phototherapy were not correlated significantl...
Source: European Journal of Pediatrics - July 16, 2021 Category: Pediatrics Source Type: research

Serum bile acid levels assist the prediction of biliary stricture and survival after liver transplantation in children
Conclusion: Serum bile acid levels can be used for non-invasive screening and prediction of biliary stricture and mortality in children after liver transplantation.What is Known:• Biliary stricture is a major biliary complication after pediatric liver transplantation, and we showed the serum bile acid level significantly associates with biliary stricture.What is New:• In this study, we demonstrated the serum bile acid level may assist in the early detection of biliary stricture and mortality non-invasively. (Source: European Journal of Pediatrics)
Source: European Journal of Pediatrics - July 16, 2021 Category: Pediatrics Source Type: research

Differential diagnostic features between congenital haemangioma, KHE, and congenital fibrosarcoma: a single-centre experience
Conclusion: Data of cases managed at the vascular anomaly clinic during the period 2015 through 2019 were retrospectively analysed. The study included three groups of patients: cases diagnosed as congenital haemangioma (9 cases), cases of Kaposiform Haemangioendothelioma who presented in the neonatal period (7 cases), as well as cases of congenital fibrosarcoma (4 cases) that were referred to the vascular anomaly clinic because of apparent similarity with vascular tumours. The hallmark of the study was to compare clinical and imaging features in the three groups to facilitate differentiation and remove diagnostic confusion...
Source: European Journal of Pediatrics - July 16, 2021 Category: Pediatrics Source Type: research

Infanticide, neonaticide, and post-neonaticide: racial/ethnic disparities in the United States.
Conclusion: Reasons for the disparities found in this study are multifactorial. We believe that access to healthcare needs to be improved and community resources need to be made more available to address the proposed mechanisms that lead to infanticide.What is Known:•Among injury-related causes of death in infants, homicide has consistently been ranked as the second leading cause of injury-related death in this age group.What is New:•Males and non-Hispanic (NH) Blacks were more likely to be victims of infanticide and post-neonaticide, compared to females and NH Whites, respectively, whereas foreign-born residents...
Source: European Journal of Pediatrics - July 16, 2021 Category: Pediatrics Source Type: research