Probiotic sepsis in preterm neonates —a systematic review
Conclusion: Probiotics sepsis is relatively an uncommon event in preterm infants. Majority of the cases recovered after antibiotic or antifungal treatment. The importance of optimal surveillance and treatment of probiotic sepsis and research towards alternatives to probiotics (e.g. postbiotics) is emphasised.What is Known:• Probiotics have been shown to reduce necrotising enterocolitis, late-onset sepsis, all-cause mortality, and time to reach full enteral feeds in preterm infants.• Despite the evidence, use of probiotics is not universal due to concerns regarding probiotic-associated sepsis in preterm infants.What is ...
Source: European Journal of Pediatrics - May 16, 2022 Category: Pediatrics Source Type: research

Frequency of family meals and food consumption in families at high risk of type 2 diabetes: the Feel4Diabetes-study
Conclusions: The frequency of family meals is positively associated with improved food consumption patterns (i.e., higher intake of fruits and vegetables and reduced consumption of sweets) in both parents and children. However, the association in children is partially mediated by parents ’ diet quality. The promotion of consuming meals together in the family could be a potentially effective strategy for interventions aiming to establish and maintain healthy food consumption patterns among children.Trial registration: The Feel4Diabetes-study is registered with the clinical trials registry (NCT02393872),http://clinicaltria...
Source: European Journal of Pediatrics - May 16, 2022 Category: Pediatrics Source Type: research

Predictors of cochleovestibular dysfunction in children with congenital cytomegalovirus infection
Conclusion: Besides the symptomatic status of the CMV infection at birth, we found that antenatal imaging brain damage and early infection (mainly during the first trimester) constitute the two best independent predictive factors of inner ear involvement in congenitally CMV-infected children.What is Known:• Congenital cytomegalovirus infection is the leading infectious cause of neurological disabilities and sensorineural hearing loss in children  and responsible of vestibular disorders, which are probably underestimated.• No articles have yet defined the predictive factors of the entire inner ear impairment (vesti...
Source: European Journal of Pediatrics - May 13, 2022 Category: Pediatrics Source Type: research

Epidemiology of minor blunt head trauma in infants younger than 3  months
Conclusion:  Most head injuries in infants younger than 3 months are benign, and the rate of ciTBI is low. Prevention strategies should focus on falls onto hard surfaces from furniture, strollers, and caregivers’ arms. Optimizing imaging studies should be a priority in this population.What is Known:• Infants younger than 3 months are vulnerable to minor blunt head trauma due to their age and to difficulties in assessing the subtle symptoms and minimal physical findings detected on examination.• A low threshold for CT scan is recommended in this population.What is New:• Most cases of blunt head trauma in infants ...
Source: European Journal of Pediatrics - May 12, 2022 Category: Pediatrics Source Type: research

Active video gaming in primary ciliary dyskinesia: a randomized controlled trial
Conclusion: The AVGs positively affect pulmonary (pulmonary function, respiratory muscle strength) and extrapulmonary (peripheral muscle strength, exercise capacity, SMO2, physical activity, ADL, and QOL) characteristics in children with PCD. The AVGs may be added to the pulmonary rehabilitation program as an exercise training modality in patients with PCD.   Trial registration: This study registered at ClinicalTrials.gov with NCT03832491 on February 6, 2019.What is Known:• It is indicated that exercise capacity is increased with traditional exercise-training in a case report of Kartagener Syndrome.What is New:...
Source: European Journal of Pediatrics - May 10, 2022 Category: Pediatrics Source Type: research

Are transition preparation consultations for adolescents with chronic conditions valuable? A mixed-methods study
ConclusionWhat is Known:• In adolescents with chronic conditions, it is advocated to personalize transition care according to the clinical and social context, pointed out as potentially impacting.• Little is known about the most effective ways to prepare patients according to their needs.What is New:• Based on a global approach to adolescent health, transition preparation consultations are delivered by specially trained physicians.• They are a feasible and valuable way to highlight facilitators and barriers to successful transition and initiate the adolescents’ own vision of their future. (Source: European Journal of Pediatrics)
Source: European Journal of Pediatrics - May 10, 2022 Category: Pediatrics Source Type: research

Comparison of CRIB-II with SNAPPE-II for predicting survival and morbidities before hospital discharge in neonates with gestation ≤ 32 weeks: a prospective multicentric observational study
Conclusion: In infants with gestational age of ≤ 32 weeks, both CRIB-II and SNAPPE-II are good scoring systems for predicting mortality. CRIB-II, being a simpler scoring system and having better predictive ability for major morbidities and combined adverse outcome, is preferable over SNAPPE-II.What is Known:• SNAPPE-II and CRIB-II scores have good predictive ability on in-hospital mortality in preterm neonates.What is New:• SNAPPE-II and CRIB-II both have good predictive ability for mortality, but CRIB-II has better ability for short-term morbidities related to the prematurity. (Source: European Journal of Pediatrics)
Source: European Journal of Pediatrics - May 6, 2022 Category: Pediatrics Source Type: research

Trisomy 18 —when the diagnosis is compatible with life
Conclusions: Knowledge of the multiple comorbidities and complex care needs of children with this syndrome is crucial. Every-day care and decisions about invasive treatments may raise ethical issues. Early referral to pediatric palliative care teams is essential to promote a holistic advanced care plan for both the patient and his family.What is Known:• The increase in survival and the high morbimortality that trisomy 18 still entails demands a careful deliberation on the use of invasive treatment.What is New:• Recent studies show that the labels of “incompatible with life”/“lethal” are not adequate, establishi...
Source: European Journal of Pediatrics - May 6, 2022 Category: Pediatrics Source Type: research

Pulmonary function tests in the follow-up of children with COVID-19
Conclusions:  Our study suggests that the persistence of respiratory symptoms is not related to the severity of acute COVID-19 in children. The inflammatory process due to COVID-19 may continue regardless of its severity, and consequently, peripheral airways may be affected.What is Known:• As compared with adults, children with COVID-19 exhibit a milder disease course and lower mortality rates. However, due to the lack of follow-up studies on children, the long-term effects of their contracting the disease are unknown.What is New:• Although COVID-19 has been thought to have a milder course in children, respiratory sy...
Source: European Journal of Pediatrics - May 6, 2022 Category: Pediatrics Source Type: research

Neurological assessment of newborns with spinal muscular atrophy identified through neonatal screening
Conclusions: Our results suggest that the combination of both scales increases the possibility to detect neonatal neurological signs and to define different early patterns of involvement also identifying paucisymptomatic patients.What is Known:• The use of new therapeutic options in presymptomatic SMA patients leads to a dramatic reduction of the onset and severity of the diesease.• The already existing tools commonly used in Type I SMA (HINE and CHOP-intend) may not be suitable to identify minor neurological signs in the neonatal period.What is New:• Combining the HNNE and the floppy infant module, we were able to i...
Source: European Journal of Pediatrics - May 6, 2022 Category: Pediatrics Source Type: research

Implementing an early childhood development intervention with routine immunization visits in India: a feasibility trial
Conclusion: Our findings suggest integrating an ECD intervention with routine healthcare visits is a feasible and promising strategy for supporting ECD in India. Further studies are needed to determine the effectiveness of SDP on children ’s development.Trial registration: ClinicalTrials.gov Identifier: NCT04167254.What is Known:• Interventions are increasingly being developed to target responsive caregiving and opportunities for learning because of their potential to support early childhood development (ECD) in low- and middle-income countries where 250 million children under the age of 5 years fail to reach their ful...
Source: European Journal of Pediatrics - May 5, 2022 Category: Pediatrics Source Type: research

Anxiety, depression, and quality of life in parents of children with congenital hyperinsulinism
Conclusion: Symptoms of depression and anxiety are alarmingly prevalent in parents of children with CHI. Psychological screening of parents should be initiated to ensure early identification of psychological strains and psychosocial support should be offered as needed. A good support network and regular work activities can improve parental mental health and well-being.What is Known:• Psychosocial strains and reduced quality of life are common in parents of chronically ill children.What is New:• In this first study evaluating mental health, family burden, and quality of life in parents of children with congenital hype...
Source: European Journal of Pediatrics - May 4, 2022 Category: Pediatrics Source Type: research

Assessing floppy infants: a new module
Conclusion: Our study suggest that the module can be easily used in a clinical setting as an add-on to the regular neonatal neurological examination in newborns identified as hypotonic on routine examination. Larger cohorts are needed to establish the accuracy of the prognostic value of the module in the differential diagnosis of floppy infant.What is Known:• Hypotonia is one of the key signs in newborns with neuromuscular disorders and can be associated with a wide range of other conditions (central nervous system involvement, genetic and metabolic diseases).• Weakness or/and contractures can identify infants with a ...
Source: European Journal of Pediatrics - May 4, 2022 Category: Pediatrics Source Type: research

Advance care planning and the parental geographical background in pediatric palliative home care: a retrospective chart review
Conclusions: Even this study indicates that the parental geographical background as an important sociocultural aspect might have an impact on ACP decisions for children and adolescents with life-limiting conditions, other factors as the patients ’ underlying disease can be more crucial for decision making in pediatric palliative care. The reason for the differences found might lay in cultural preferences or barriers to appropriate care. The inclusion of sociocultural aspects in decision-making is crucial to guarantee culture-sensitive, pa tient-centered pediatric palliative care.What is Known:• Decision making processe...
Source: European Journal of Pediatrics - May 4, 2022 Category: Pediatrics Source Type: research

Intravenous maintenance fluid therapy practice in the pediatric acute and critical care settings: a European and Middle Eastern survey
Conclusions: Our study showed considerable variability in clinical prescribing practice of IV-MFT in acute pediatric settings across Europe and the Middle East. There is an urgent need to develop evidence-based guidelines for IV-MFT prescription in acute and critically ill children.What is Known:• The administration of maintenance intravenous fluid therapy is a standard of care for a lot of hospitalized children• Maintenance intravenous fluid therapy prescriptions are often based on Holliday and Segar ’s historical guidelines even if this practice has been associated with several complications.What is New:• This...
Source: European Journal of Pediatrics - May 3, 2022 Category: Pediatrics Source Type: research