Glucose-Regulated Protein 94 Mediates the Proliferation and Metastasis through the Regulation of ETV1 and MAPK Pathway in Colorectal Cancer
Int J Med Sci. 2021 Mar 27;18(11):2251-2261. doi: 10.7150/ijms.56024. eCollection 2021.ABSTRACTColorectal cancer (CRC) is a worldwide health problem. Glucose-regulated protein 94 (GRP94) is known as an important endoplasmic reticulum-stress response protein that shows correlation with aggressive cancer behavior. However, the role of GRP94 in CRC is still unclear. Our results showed that silencing GRP94 (GRP94-KD) reduced cell proliferation, invasion and migration of CRC cells and suppressed tumorigenesis in the xenograft mouse model. Rescue assay showed that ETV1 overexpression reversed the effect of GRP94 on cell prolifer...
Source: International Journal of Medical Sciences - May 10, 2021 Category: Biomedical Science Authors: Uyanga Batzorig Po-Li Wei Weu Wang Chien-Yu Huang Yu-Jia Chang Source Type: research

Term Newborns with relatively low Tissue Oxygen Saturation Levels soon after Birth are predisposed to Neonatal Respiratory Disorders in Low-risk, Elective Cesarean Sections
Conclusions: The StO2 values in the RD group were lower than those in the NR group at 3 and 5 minutes after birth, suggesting that neonates with low StO2 levels soon after birth may be predisposed to clinically diagnosed neonatal respiratory disorders.PMID:33967601 | PMC:PMC8100654 | DOI:10.7150/ijms.53945 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - May 10, 2021 Category: Biomedical Science Authors: Kenta Kawai Toshiyuki Uchida Mari Mukai Masako Matsumoto Toshiya Itoh Tomoaki Oda Yoshimasa Horikoshi Kazunao Suzuki Yukiko Kohmura-Kobayashi Naomi Furuta-Isomura Chizuko Yaguchi Masatsugu Niwayama Hiroaki Itoh Naohiro Kanayama Source Type: research

Morpho-structural characteristics of feet in patients with rheumatoid arthritis: A cross sectional study
Conclusions: The most common foot type in patients with RA is the pronated foot type with deformities in the MTP joints without Hallux Valgus. However, a percentage of patients with RA presents supinated foot type. The evolution of the disease shows some morphological changes in terms of patient's feet. The presence of more developed foot deformities is increased, such us Hallux Valgus or MTP joints deformity (Grade 3 in the Nijmegen classification scale).PMID:33967602 | PMC:PMC8100651 | DOI:10.7150/ijms.56935 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - May 10, 2021 Category: Biomedical Science Authors: Andres Reinoso-Cobo Pekka Anttila Ana Belen Ortega-Avila Pablo Cervera-Garvi Eva Lopezosa-Reca Ana Marchena-Rodriguez Laura Ramos-Petersen Gabriel Gijon-Nogueron Source Type: research

Radiomics Signature: A potential biomarker for the prediction of survival in Advanced Hepatocellular Carcinoma
Conclusions: Apatinib plus TACE may improve OS and prolonged TTP in the patients with advanced HCC. The clinical-radiomics nomograms, a noninvasive pretreatment prediction tool that incorporate radiomics signature and AFP, demonstrated good prediction accuracy for OS and TTP in these patients. These results indicate that the clinical-radiomics nomograms may provide novel insight for precise personalized medicine approaches in the patients with advanced HCC.PMID:33967603 | PMC:PMC8100633 | DOI:10.7150/ijms.55510 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - May 10, 2021 Category: Biomedical Science Authors: Lingli Li Xuefeng Kan Yongjun Zhao Bo Liang Tianhe Ye Lian Yang Chuansheng Zheng Source Type: research

Anti-inflammatory effects of < em > Flos Lonicerae Japonicae < /em > Water Extract are regulated by the STAT/NF- κB pathway and HO-1 expression in Virus-infected RAW264.7 cells
This study examined the effect of the Flos Lonicerae Japonicae water extract (FLJWE), chlorogenic acid, and luteolin on pseudorabies virus (PRV)-induced inflammation in RAW264.7 cells and elucidated related molecular mechanisms. The results revealed that FLJWE and luteolin, but not chlorogenic acid, inhibited the production of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and inflammatory cytokines in PRV-infected RAW 264.7 cells. We found that the FLJWE and luteolin suppressed nuclear factor (NF)-κB activation by inhibiting the phosphorylation of signal transducer and activator of transcription 1...
Source: International Journal of Medical Sciences - May 10, 2021 Category: Biomedical Science Authors: Hui-Wen Lin Yi-Ju Lee Deng-Jye Yang Ming-Chang Hsieh Ching-Chung Chen Wei-Li Hsu Yuan-Yen Chang Cheng-Wei Liu Source Type: research

Advances in the Study of Antitumour Immunotherapy for Newcastle Disease Virus
This article reviews the preclinical research, clinical application and development of Newcastle disease virus (NDV) in the field of cancer therapy. Based on the distinctive antitumour properties of NDV and its positive interaction with the patient's immune system, this biologic could be considered a major breakthrough in cancer treatment. On one hand, NDV infection creates an inflammatory environment in the tumour microenvironment, which can directly activate NK cells, monocytes, macrophages and dendritic cells and promote the recruitment of immune cells. On the other hand, NDV can induce the upregulation of immune checkp...
Source: International Journal of Medical Sciences - May 10, 2021 Category: Biomedical Science Authors: Qiuxing Meng Jian He Liping Zhong Yongxiang Zhao Source Type: research

H. pylori is related to NAFLD but only in female: A Cross-sectional Study
Conclusion: H. pylori infection is related to NAFLD in female patients. The relationship between H. pylori and NAFLD may be mediated by markers of lipid metabolism and glycometabolism.PMID:33967606 | PMC:PMC8100637 | DOI:10.7150/ijms.50748 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - May 10, 2021 Category: Biomedical Science Authors: Jingwei Wang Fengxiao Dong Hui Su Licun Zhu Sujun Shao Jing Wu Hong Liu Source Type: research

has_circ_0071106 can be used as a diagnostic marker for type 2 diabetes
Int J Med Sci. 2021 Apr 3;18(11):2312-2320. doi: 10.7150/ijms.52575. eCollection 2021.ABSTRACTWe explored has_circ_0071106 as a diagnostic marker for type 2 diabetes (T2DM) in south China, and predicted the functional mechanism of the target circRNA. A total of 107 T2DM patients and 107 healthy reference persons were included as the research objects. In the first stage, the circRNA microarray was used to detect the peripheral blood of 4 T2DM and 4 control groups to screen the differential expression profile of circRNA. In the second stage, four circRNAs were screened from the differential expression profiles of circRNA, an...
Source: International Journal of Medical Sciences - May 10, 2021 Category: Biomedical Science Authors: Zheng Yingying Yu Yongji Cheng Qiuting Liao Rifang Zeng Zhuanping Source Type: research

Completed absorption of coronavirus disease 2019 (COVID-19) pneumonia lesions: a preliminary study
Conclusion: The pulmonary lesions in some mild COVID-19 patients (generally with normal laboratory indicators at admission, GGOs as the main manifestation on initial CT, and representation of continuous absorption after treatment) could be completely absorbed with a mean duration of 31.6 days.PMID:33967608 | PMC:PMC8100646 | DOI:10.7150/ijms.54675 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - May 10, 2021 Category: Biomedical Science Authors: Xue-Yan Liu Fa-Jin Lv Sheng-Xiu Lv Bin-Jie Fu Wang-Jia Li Md Yu Ouyang Zhi-Gang Chu Source Type: research

Relationship between Tertiary Lymphoid Structure and the Prognosis and Clinicopathologic Characteristics in Solid Tumors
Int J Med Sci. 2021 Apr 7;18(11):2327-2338. doi: 10.7150/ijms.56347. eCollection 2021.ABSTRACTBackground: An increasing number of studies had shown that tertiary lymphoid structure (TLS) plays an important role in tumor progression. However, the prognostic role of TLS in various tumors remains controversial. This meta-analysis aims to investigate the clinicopathological and prognostic values of TLS in solid tumors. Methods: A systematic search was conducted in PubMed, EMBASE and Cochrane Library undated to November 2, 2020. Odds ratios of clinical parameters, hazard ratio (HR) of overall survival (OS), relapse-free surviva...
Source: International Journal of Medical Sciences - May 10, 2021 Category: Biomedical Science Authors: Zhan Zhao Hui Ding Zheng-Bin Lin Sheng-Hui Qiu Yi-Ran Zhang Yan-Guan Guo Xiao-Dong Chu Loi I Sam Jing-Hua Pan Yun-Long Pan Source Type: research

Impact of < em > pentraxin 3 < /em > genetic variants on uterine cervical cancer clinicopathologic characteristics
In conclusions, PTX3 genetic variants are not associated with carcinogenesis and clinicopathological variables of uterine cervix and patient survival in Taiwanese women. The only independent predictor for the 5 years survival is pelvic lymph node metastasis.PMID:33967610 | PMC:PMC8100632 | DOI:10.7150/ijms.57886 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - May 10, 2021 Category: Biomedical Science Authors: Yi-Hung Sun Ying-Hsiang Chou Chun-Hao Wang Yi-Hsuan Hsiao Chung-Yuan Lee Shun-Fa Yang Po-Hui Wang Source Type: research

The associations and roles of microRNA single-nucleotide polymorphisms in cervical cancer
Int J Med Sci. 2021 Apr 7;18(11):2347-2354. doi: 10.7150/ijms.57990. eCollection 2021.ABSTRACTCervical cancer is one of the fourth most common gynecological malignancies and has been identified as the fourth leading cause of cancer death in women worldwide. MicroRNAs (miRNAs) are single-stranded sequences of noncoding RNAs that are approximately 22-24 nucleotides in length. They modulate posttranscriptional mRNA expression and play critical roles in cervical cancer. Single nucleotide polymorphisms (SNPs) in miRNA genes may alter miRNA expression and maturation and have been associated with various cancers. This review main...
Source: International Journal of Medical Sciences - May 10, 2021 Category: Biomedical Science Authors: Yaheng Li Chuanyin Li Shuyuan Liu Jia Yang Li Shi Yufeng Yao Source Type: research

Preparation of FA-targeted magnetic nanocomposites co-loading TFPI-2 plasmid and cis-platinum and its targeted therapy effects on nasopharyngeal carcinoma
Int J Med Sci. 2021 Apr 9;18(11):2355-2365. doi: 10.7150/ijms.52643. eCollection 2021.ABSTRACTThe majority of patients diagnosed with nasopharyngeal carcinoma (NPC) present with advanced-stage disease. The main treatment for these patients is concurrent chemoradiotherapy, which has various side effects. To improve the therapeutic effects and reduce the side effects of NPC chemoradiotherapy, we constructed a multifunctional folic acid (FA)-targeted magnetic nanocomposite codelivering tissue factor pathway inhibitor-2 (TFPI-2) and cisplatin (CDDP). This novel nanocomposite (FA-MNP/CDDP/TFPI-2) was obtained by amidation and e...
Source: International Journal of Medical Sciences - May 10, 2021 Category: Biomedical Science Authors: Fang Liu Bojie Chen Weifeng Chen Shuaijun Chen Dong Ma Minqiang Xie Source Type: research

Clinical course of patients on maintenance hemodialysis and COVID-19: a retrospective longitudinal study
Int J Med Sci. 2021 Apr 12;18(11):2366-2371. doi: 10.7150/ijms.49337. eCollection 2021.ABSTRACTCoronavirus Disease 2019 (COVID-19) emerges as a global pandemic and there is a lack of evidence about the clinical course and outcome of patients on maintenance hemodialysis (MHD). Here we conducted a retrospective longitudinal study aimed to analyze the clinical features and outcome of MHD patients hospitalized with COVID-19. Of 3126 inpatients with COVID-19 at 3 Branches of Wuhan Tongji Hospital from Jan 18th to Mar 9th, 2020, 19 patients were undergoing maintenance hemodialysis. Among the 19 MHD patients with COVID-19, 6 pati...
Source: International Journal of Medical Sciences - May 10, 2021 Category: Biomedical Science Authors: Guan-Nan Jin Ze-Yang Ding Gan-Xun Li Jun-Bo Hu Ji-Hong Liu Bixiang Zhang Xiao-Ping Chen Source Type: research

Treatments of Sexual Dysfunction in Opioid Substitution Therapy Patients: A Systematic Review and Meta-Analysis
Int J Med Sci. 2021 Apr 12;18(11):2372-2380. doi: 10.7150/ijms.57641. eCollection 2021.ABSTRACTSexual dysfunction is a common condition in the opioid substitution therapy (OST) population. We aimed to determine the efficacy and safety of treatment for sexual dysfunction in the OST population. We searched for interventional studies from Medline, PubMed, and Scopus. Three independent authors conducted a risk-of-bias assessment (RoB 2). A total of seven studies (five randomized-controlled trials, two quasi-experimental), including 473 patients with sexual dysfunction, were identified. Among these, three bupropion (n=207), one...
Source: International Journal of Medical Sciences - May 10, 2021 Category: Biomedical Science Authors: Fitri Fareez Ramli Muhammad Hasif Azizi Syed Alhafiz Syed Hashim Source Type: research

Effects of neuromuscular blocking agents on the clinical performance of i-gel < sup > ® < /sup > and surgical condition in elderly patients undergoing hand surgery: a prospective randomized controlled trial
Conclusions: Rocuronium did not enhance the success rate of inserting the i-gel® or the surgical condition in elderly patients. However, using rocuronium reduced PIP, the frequency of spontaneous breathing, the requirement for additional fentanyl and patients' recovery time.PMID:33967615 | PMC:PMC8100647 | DOI:10.7150/ijms.57489 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - May 10, 2021 Category: Biomedical Science Authors: Choon-Kyu Cho Minhye Change Seok-Jin Lee Tae-Yun Sung Source Type: research

Value of anal swabs for SARS-COV-2 detection: a literature review
Int J Med Sci. 2021 Apr 16;18(11):2389-2393. doi: 10.7150/ijms.59382. eCollection 2021.ABSTRACTFacing the unprecedented global public health crisis caused by coronavirus disease 2019 (COVID-19), nucleic acid tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are the gold standard for diagnosing COVID-19. The asymptomatic carriers were not suspected of playing a significant role in the ongoing pandemic, and universal nucleic acid screening in close contacts of confirmed cases and asymptomatic carriers has been carried out in many medium- and high-risk areas for the spread of the virus. Recently, anal swa...
Source: International Journal of Medical Sciences - May 10, 2021 Category: Biomedical Science Authors: Yuliang Wang Xiaobo Chen Feng Wang Jie Geng Bingxu Liu Feng Han Source Type: research

Correlation between ground-glass opacity on pulmonary CT and the levels of inflammatory cytokines in patients with moderate-to-severe COVID-19 pneumonia
Int J Med Sci. 2021 Apr 16;18(11):2394-2400. doi: 10.7150/ijms.56683. eCollection 2021.ABSTRACTObjectives: Comparative analysis of laboratory data in moderate-to-severe COVID-19 patients presenting with or without ground-glass opacities (GGOs). Methods: This retrospective study examined 61 patients with moderate-to-severe COVID-19, as defined by the report of the WHO-China Joint Mission on COVID-19. All patients were admitted to the Department of Infectious Diseases, Wuhan Union Hospital from Dec 28, 2019 to Feb 22, 2020 and classified into a GGO group or a non-GGO group based on CT results. The clinical characteristics an...
Source: International Journal of Medical Sciences - May 10, 2021 Category: Biomedical Science Authors: Zubo Wu Xiaoping Liu Jie Liu Feng Zhu Yali Liu Yalan Liu Hua Peng Source Type: research

Traditional Chinese medicine prescription Guizhi Fuling Pills in the treatment of endometriosis
Int J Med Sci. 2021 Apr 16;18(11):2401-2408. doi: 10.7150/ijms.55789. eCollection 2021.ABSTRACTEndometriosis (EMs) is recorded as Zheng Jia in traditional Chinese medicine (TCM) books. Guizhi Fuling Pills (GFPs), a classic prescription for promoting blood circulation and removing blood stasis, is widely used for women's blood stasis diseases represented by Zheng Jia. At present, it has been applied to treat EMs in clinical settings. In this review, we systematically summarized the active ingredients and pharmacological mechanism of five Chinese herbs contained in GFPs and clinical applications of GFPs. The potential pathwa...
Source: International Journal of Medical Sciences - May 10, 2021 Category: Biomedical Science Authors: Xin Wang Yaxin Shi Li Xu Zilu Wang Yanfei Wang Wei Shi Ke Ma Source Type: research

Postoperative pain assessment of robotic nipple-sparing mastectomy with immediate prepectoral prosthesis breast reconstruction: a comparison with conventional nipple-sparing mastectomy
Conclusions: Despite a statistical difference in the resting NRS scores during the early postoperative phase, the absence of any significant difference in the requirement of additional analgesics between the groups suggested that RNSM does not significantly attenuate postoperative pain intensity.PMID:33967619 | PMC:PMC8100638 | DOI:10.7150/ijms.56997 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - May 10, 2021 Category: Biomedical Science Authors: Jiae Moon Jeea Lee Dong Won Lee Hye Sun Lee Da Jung Nam Min Jung Kim Na Young Kim Hyung Seok Park Source Type: research

< em > Cedrus atlantica < /em > Extract Suppress Glioblastoma Growth through Promotion of Genotoxicity and Apoptosis: < em > In Vitro < /em > and < em > In Vivo < /em > Studies
Int J Med Sci. 2021 Apr 22;18(11):2417-2430. doi: 10.7150/ijms.54468. eCollection 2021.ABSTRACTGlioblastoma (GBM) is the most common malignant primary brain tumor in humans, exhibiting highly infiltrative growth and drug resistance to conventional chemotherapy. Cedrus atlantica (CAt) extract has been shown to decrease postoperative pain and inhibit the growth of K562 leukemia cells. The aim of this study was to assess the anti-GBM activity and molecular mechanism of CAt extract in vitro and in vivo. The results showed that CAt extract greatly suppressed GBM cells both in vitro and in vivo and enhanced the survival rate in ...
Source: International Journal of Medical Sciences - May 10, 2021 Category: Biomedical Science Authors: Kai-Fu Chang Jinghua Tsai Chang Xiao-Fan Huang Ya-Chih Huang Chia-Yu Li Jun-Cheng Weng Chih-Yen Hsiao Hui-Ju Hsu Nu-Man Tsai Source Type: research

Leptin regulates OPG and RANKL expression in Gingival Fibroblasts and Tissues of Chronic Periodontitis Patients
Int J Med Sci. 2021 Apr 22;18(11):2431-2437. doi: 10.7150/ijms.56151. eCollection 2021.ABSTRACTObjective: Chronic periodontitis is a bone-destructive disease affecting periodontal support structures. Although leptin has a protective effect against periodontitis, the underlying mechanism remains unclear. Therefore, this study aimed to investigate the possible role of leptin by examining its relationship with OPG and RANKL in human gingival tissues obtained from patients with chronic periodontitis. Method: Twenty-two patients with chronic periodontitis were enrolled (10 with moderate periodontitis and 12 with severe periodon...
Source: International Journal of Medical Sciences - May 10, 2021 Category: Biomedical Science Authors: Yiting Guo Chunjiao Xu Xiaoshan Wu Wenrui Zhang Yumei Sun Alisha Shrestha Source Type: research

Circular RNAs in stem cell differentiation: a sponge-like role for miRNAs
In conclusion, circRNAs regulate the stem cells differentiation via their ambient binding efficacy to modulate miRNA expression, as well as related gene translation. We believe that this review will provide reference guidance for future studies on stem cell differentiation.PMID:33967622 | PMC:PMC8100645 | DOI:10.7150/ijms.56457 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - May 10, 2021 Category: Biomedical Science Authors: Jian Zhou Cheng Qiu Zhihua Fan Tianyi Liu Tang Liu Source Type: research

Correlations among Pulmonary DJ-1, VDR and Nrf-2 in patients with Chronic Obstructive Pulmonary Disease: A Case-control Study
In conclusion, DJ-1, VDR and Nrf-2 were decreased in COPD patients compared with control subjects. The reduction of DJ-1 and VDR associating with Nrf-2 downregulation may be involved in the process of COPD.PMID:33967623 | PMC:PMC8100631 | DOI:10.7150/ijms.58452 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - May 10, 2021 Category: Biomedical Science Authors: Ying Xiang Lin Fu Hui-Xian Xiang Ling Zheng Zhu-Xia Tan Li-Xiang Wang Wei Cao De-Xiang Xu Hui Zhao Source Type: research

The impact of Aurora kinase A genetic polymorphisms on cervical cancer progression and clinicopathologic characteristics
In conclusion, tumor size and pelvic lymph node status rather than AURKA SNPs were the most obvious independent parameter that could significantly predict 5 years survival rate in Taiwanese women with cervical cancer.PMID:33967624 | PMC:PMC8100634 | DOI:10.7150/ijms.58516 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - May 10, 2021 Category: Biomedical Science Authors: Pei-Ju Wu Chun-Hao Wang Ming-Hong Hsieh Chung-Yuan Lee Po-Hui Wang Chiao-Wen Lin Shun-Fa Yang Maw-Sheng Lee Source Type: research

Glucose-Regulated Protein 94 Mediates the Proliferation and Metastasis through the Regulation of ETV1 and MAPK Pathway in Colorectal Cancer
Int J Med Sci. 2021 Mar 27;18(11):2251-2261. doi: 10.7150/ijms.56024. eCollection 2021.ABSTRACTColorectal cancer (CRC) is a worldwide health problem. Glucose-regulated protein 94 (GRP94) is known as an important endoplasmic reticulum-stress response protein that shows correlation with aggressive cancer behavior. However, the role of GRP94 in CRC is still unclear. Our results showed that silencing GRP94 (GRP94-KD) reduced cell proliferation, invasion and migration of CRC cells and suppressed tumorigenesis in the xenograft mouse model. Rescue assay showed that ETV1 overexpression reversed the effect of GRP94 on cell prolifer...
Source: International Journal of Medical Sciences - May 10, 2021 Category: Biomedical Science Authors: Uyanga Batzorig Po-Li Wei Weu Wang Chien-Yu Huang Yu-Jia Chang Source Type: research

Term Newborns with relatively low Tissue Oxygen Saturation Levels soon after Birth are predisposed to Neonatal Respiratory Disorders in Low-risk, Elective Cesarean Sections
Conclusions: The StO2 values in the RD group were lower than those in the NR group at 3 and 5 minutes after birth, suggesting that neonates with low StO2 levels soon after birth may be predisposed to clinically diagnosed neonatal respiratory disorders.PMID:33967601 | PMC:PMC8100654 | DOI:10.7150/ijms.53945 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - May 10, 2021 Category: Biomedical Science Authors: Kenta Kawai Toshiyuki Uchida Mari Mukai Masako Matsumoto Toshiya Itoh Tomoaki Oda Yoshimasa Horikoshi Kazunao Suzuki Yukiko Kohmura-Kobayashi Naomi Furuta-Isomura Chizuko Yaguchi Masatsugu Niwayama Hiroaki Itoh Naohiro Kanayama Source Type: research

Morpho-structural characteristics of feet in patients with rheumatoid arthritis: A cross sectional study
Conclusions: The most common foot type in patients with RA is the pronated foot type with deformities in the MTP joints without Hallux Valgus. However, a percentage of patients with RA presents supinated foot type. The evolution of the disease shows some morphological changes in terms of patient's feet. The presence of more developed foot deformities is increased, such us Hallux Valgus or MTP joints deformity (Grade 3 in the Nijmegen classification scale).PMID:33967602 | PMC:PMC8100651 | DOI:10.7150/ijms.56935 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - May 10, 2021 Category: Biomedical Science Authors: Andres Reinoso-Cobo Pekka Anttila Ana Belen Ortega-Avila Pablo Cervera-Garvi Eva Lopezosa-Reca Ana Marchena-Rodriguez Laura Ramos-Petersen Gabriel Gijon-Nogueron Source Type: research

Radiomics Signature: A potential biomarker for the prediction of survival in Advanced Hepatocellular Carcinoma
Conclusions: Apatinib plus TACE may improve OS and prolonged TTP in the patients with advanced HCC. The clinical-radiomics nomograms, a noninvasive pretreatment prediction tool that incorporate radiomics signature and AFP, demonstrated good prediction accuracy for OS and TTP in these patients. These results indicate that the clinical-radiomics nomograms may provide novel insight for precise personalized medicine approaches in the patients with advanced HCC.PMID:33967603 | PMC:PMC8100633 | DOI:10.7150/ijms.55510 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - May 10, 2021 Category: Biomedical Science Authors: Lingli Li Xuefeng Kan Yongjun Zhao Bo Liang Tianhe Ye Lian Yang Chuansheng Zheng Source Type: research

Anti-inflammatory effects of < em > Flos Lonicerae Japonicae < /em > Water Extract are regulated by the STAT/NF- κB pathway and HO-1 expression in Virus-infected RAW264.7 cells
This study examined the effect of the Flos Lonicerae Japonicae water extract (FLJWE), chlorogenic acid, and luteolin on pseudorabies virus (PRV)-induced inflammation in RAW264.7 cells and elucidated related molecular mechanisms. The results revealed that FLJWE and luteolin, but not chlorogenic acid, inhibited the production of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and inflammatory cytokines in PRV-infected RAW 264.7 cells. We found that the FLJWE and luteolin suppressed nuclear factor (NF)-κB activation by inhibiting the phosphorylation of signal transducer and activator of transcription 1...
Source: International Journal of Medical Sciences - May 10, 2021 Category: Biomedical Science Authors: Hui-Wen Lin Yi-Ju Lee Deng-Jye Yang Ming-Chang Hsieh Ching-Chung Chen Wei-Li Hsu Yuan-Yen Chang Cheng-Wei Liu Source Type: research

Advances in the Study of Antitumour Immunotherapy for Newcastle Disease Virus
This article reviews the preclinical research, clinical application and development of Newcastle disease virus (NDV) in the field of cancer therapy. Based on the distinctive antitumour properties of NDV and its positive interaction with the patient's immune system, this biologic could be considered a major breakthrough in cancer treatment. On one hand, NDV infection creates an inflammatory environment in the tumour microenvironment, which can directly activate NK cells, monocytes, macrophages and dendritic cells and promote the recruitment of immune cells. On the other hand, NDV can induce the upregulation of immune checkp...
Source: International Journal of Medical Sciences - May 10, 2021 Category: Biomedical Science Authors: Qiuxing Meng Jian He Liping Zhong Yongxiang Zhao Source Type: research

H. pylori is related to NAFLD but only in female: A Cross-sectional Study
Conclusion: H. pylori infection is related to NAFLD in female patients. The relationship between H. pylori and NAFLD may be mediated by markers of lipid metabolism and glycometabolism.PMID:33967606 | PMC:PMC8100637 | DOI:10.7150/ijms.50748 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - May 10, 2021 Category: Biomedical Science Authors: Jingwei Wang Fengxiao Dong Hui Su Licun Zhu Sujun Shao Jing Wu Hong Liu Source Type: research

has_circ_0071106 can be used as a diagnostic marker for type 2 diabetes
Int J Med Sci. 2021 Apr 3;18(11):2312-2320. doi: 10.7150/ijms.52575. eCollection 2021.ABSTRACTWe explored has_circ_0071106 as a diagnostic marker for type 2 diabetes (T2DM) in south China, and predicted the functional mechanism of the target circRNA. A total of 107 T2DM patients and 107 healthy reference persons were included as the research objects. In the first stage, the circRNA microarray was used to detect the peripheral blood of 4 T2DM and 4 control groups to screen the differential expression profile of circRNA. In the second stage, four circRNAs were screened from the differential expression profiles of circRNA, an...
Source: International Journal of Medical Sciences - May 10, 2021 Category: Biomedical Science Authors: Zheng Yingying Yu Yongji Cheng Qiuting Liao Rifang Zeng Zhuanping Source Type: research

Completed absorption of coronavirus disease 2019 (COVID-19) pneumonia lesions: a preliminary study
Conclusion: The pulmonary lesions in some mild COVID-19 patients (generally with normal laboratory indicators at admission, GGOs as the main manifestation on initial CT, and representation of continuous absorption after treatment) could be completely absorbed with a mean duration of 31.6 days.PMID:33967608 | PMC:PMC8100646 | DOI:10.7150/ijms.54675 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - May 10, 2021 Category: Biomedical Science Authors: Xue-Yan Liu Fa-Jin Lv Sheng-Xiu Lv Bin-Jie Fu Wang-Jia Li Md Yu Ouyang Zhi-Gang Chu Source Type: research

Relationship between Tertiary Lymphoid Structure and the Prognosis and Clinicopathologic Characteristics in Solid Tumors
Int J Med Sci. 2021 Apr 7;18(11):2327-2338. doi: 10.7150/ijms.56347. eCollection 2021.ABSTRACTBackground: An increasing number of studies had shown that tertiary lymphoid structure (TLS) plays an important role in tumor progression. However, the prognostic role of TLS in various tumors remains controversial. This meta-analysis aims to investigate the clinicopathological and prognostic values of TLS in solid tumors. Methods: A systematic search was conducted in PubMed, EMBASE and Cochrane Library undated to November 2, 2020. Odds ratios of clinical parameters, hazard ratio (HR) of overall survival (OS), relapse-free surviva...
Source: International Journal of Medical Sciences - May 10, 2021 Category: Biomedical Science Authors: Zhan Zhao Hui Ding Zheng-Bin Lin Sheng-Hui Qiu Yi-Ran Zhang Yan-Guan Guo Xiao-Dong Chu Loi I Sam Jing-Hua Pan Yun-Long Pan Source Type: research

Impact of < em > pentraxin 3 < /em > genetic variants on uterine cervical cancer clinicopathologic characteristics
In conclusions, PTX3 genetic variants are not associated with carcinogenesis and clinicopathological variables of uterine cervix and patient survival in Taiwanese women. The only independent predictor for the 5 years survival is pelvic lymph node metastasis.PMID:33967610 | PMC:PMC8100632 | DOI:10.7150/ijms.57886 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - May 10, 2021 Category: Biomedical Science Authors: Yi-Hung Sun Ying-Hsiang Chou Chun-Hao Wang Yi-Hsuan Hsiao Chung-Yuan Lee Shun-Fa Yang Po-Hui Wang Source Type: research

The associations and roles of microRNA single-nucleotide polymorphisms in cervical cancer
Int J Med Sci. 2021 Apr 7;18(11):2347-2354. doi: 10.7150/ijms.57990. eCollection 2021.ABSTRACTCervical cancer is one of the fourth most common gynecological malignancies and has been identified as the fourth leading cause of cancer death in women worldwide. MicroRNAs (miRNAs) are single-stranded sequences of noncoding RNAs that are approximately 22-24 nucleotides in length. They modulate posttranscriptional mRNA expression and play critical roles in cervical cancer. Single nucleotide polymorphisms (SNPs) in miRNA genes may alter miRNA expression and maturation and have been associated with various cancers. This review main...
Source: International Journal of Medical Sciences - May 10, 2021 Category: Biomedical Science Authors: Yaheng Li Chuanyin Li Shuyuan Liu Jia Yang Li Shi Yufeng Yao Source Type: research

Preparation of FA-targeted magnetic nanocomposites co-loading TFPI-2 plasmid and cis-platinum and its targeted therapy effects on nasopharyngeal carcinoma
Int J Med Sci. 2021 Apr 9;18(11):2355-2365. doi: 10.7150/ijms.52643. eCollection 2021.ABSTRACTThe majority of patients diagnosed with nasopharyngeal carcinoma (NPC) present with advanced-stage disease. The main treatment for these patients is concurrent chemoradiotherapy, which has various side effects. To improve the therapeutic effects and reduce the side effects of NPC chemoradiotherapy, we constructed a multifunctional folic acid (FA)-targeted magnetic nanocomposite codelivering tissue factor pathway inhibitor-2 (TFPI-2) and cisplatin (CDDP). This novel nanocomposite (FA-MNP/CDDP/TFPI-2) was obtained by amidation and e...
Source: International Journal of Medical Sciences - May 10, 2021 Category: Biomedical Science Authors: Fang Liu Bojie Chen Weifeng Chen Shuaijun Chen Dong Ma Minqiang Xie Source Type: research

Clinical course of patients on maintenance hemodialysis and COVID-19: a retrospective longitudinal study
Int J Med Sci. 2021 Apr 12;18(11):2366-2371. doi: 10.7150/ijms.49337. eCollection 2021.ABSTRACTCoronavirus Disease 2019 (COVID-19) emerges as a global pandemic and there is a lack of evidence about the clinical course and outcome of patients on maintenance hemodialysis (MHD). Here we conducted a retrospective longitudinal study aimed to analyze the clinical features and outcome of MHD patients hospitalized with COVID-19. Of 3126 inpatients with COVID-19 at 3 Branches of Wuhan Tongji Hospital from Jan 18th to Mar 9th, 2020, 19 patients were undergoing maintenance hemodialysis. Among the 19 MHD patients with COVID-19, 6 pati...
Source: International Journal of Medical Sciences - May 10, 2021 Category: Biomedical Science Authors: Guan-Nan Jin Ze-Yang Ding Gan-Xun Li Jun-Bo Hu Ji-Hong Liu Bixiang Zhang Xiao-Ping Chen Source Type: research

Treatments of Sexual Dysfunction in Opioid Substitution Therapy Patients: A Systematic Review and Meta-Analysis
Int J Med Sci. 2021 Apr 12;18(11):2372-2380. doi: 10.7150/ijms.57641. eCollection 2021.ABSTRACTSexual dysfunction is a common condition in the opioid substitution therapy (OST) population. We aimed to determine the efficacy and safety of treatment for sexual dysfunction in the OST population. We searched for interventional studies from Medline, PubMed, and Scopus. Three independent authors conducted a risk-of-bias assessment (RoB 2). A total of seven studies (five randomized-controlled trials, two quasi-experimental), including 473 patients with sexual dysfunction, were identified. Among these, three bupropion (n=207), one...
Source: International Journal of Medical Sciences - May 10, 2021 Category: Biomedical Science Authors: Fitri Fareez Ramli Muhammad Hasif Azizi Syed Alhafiz Syed Hashim Source Type: research

Effects of neuromuscular blocking agents on the clinical performance of i-gel < sup > ® < /sup > and surgical condition in elderly patients undergoing hand surgery: a prospective randomized controlled trial
Conclusions: Rocuronium did not enhance the success rate of inserting the i-gel® or the surgical condition in elderly patients. However, using rocuronium reduced PIP, the frequency of spontaneous breathing, the requirement for additional fentanyl and patients' recovery time.PMID:33967615 | PMC:PMC8100647 | DOI:10.7150/ijms.57489 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - May 10, 2021 Category: Biomedical Science Authors: Choon-Kyu Cho Minhye Change Seok-Jin Lee Tae-Yun Sung Source Type: research

Value of anal swabs for SARS-COV-2 detection: a literature review
Int J Med Sci. 2021 Apr 16;18(11):2389-2393. doi: 10.7150/ijms.59382. eCollection 2021.ABSTRACTFacing the unprecedented global public health crisis caused by coronavirus disease 2019 (COVID-19), nucleic acid tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are the gold standard for diagnosing COVID-19. The asymptomatic carriers were not suspected of playing a significant role in the ongoing pandemic, and universal nucleic acid screening in close contacts of confirmed cases and asymptomatic carriers has been carried out in many medium- and high-risk areas for the spread of the virus. Recently, anal swa...
Source: International Journal of Medical Sciences - May 10, 2021 Category: Biomedical Science Authors: Yuliang Wang Xiaobo Chen Feng Wang Jie Geng Bingxu Liu Feng Han Source Type: research

Correlation between ground-glass opacity on pulmonary CT and the levels of inflammatory cytokines in patients with moderate-to-severe COVID-19 pneumonia
Int J Med Sci. 2021 Apr 16;18(11):2394-2400. doi: 10.7150/ijms.56683. eCollection 2021.ABSTRACTObjectives: Comparative analysis of laboratory data in moderate-to-severe COVID-19 patients presenting with or without ground-glass opacities (GGOs). Methods: This retrospective study examined 61 patients with moderate-to-severe COVID-19, as defined by the report of the WHO-China Joint Mission on COVID-19. All patients were admitted to the Department of Infectious Diseases, Wuhan Union Hospital from Dec 28, 2019 to Feb 22, 2020 and classified into a GGO group or a non-GGO group based on CT results. The clinical characteristics an...
Source: International Journal of Medical Sciences - May 10, 2021 Category: Biomedical Science Authors: Zubo Wu Xiaoping Liu Jie Liu Feng Zhu Yali Liu Yalan Liu Hua Peng Source Type: research

Traditional Chinese medicine prescription Guizhi Fuling Pills in the treatment of endometriosis
Int J Med Sci. 2021 Apr 16;18(11):2401-2408. doi: 10.7150/ijms.55789. eCollection 2021.ABSTRACTEndometriosis (EMs) is recorded as Zheng Jia in traditional Chinese medicine (TCM) books. Guizhi Fuling Pills (GFPs), a classic prescription for promoting blood circulation and removing blood stasis, is widely used for women's blood stasis diseases represented by Zheng Jia. At present, it has been applied to treat EMs in clinical settings. In this review, we systematically summarized the active ingredients and pharmacological mechanism of five Chinese herbs contained in GFPs and clinical applications of GFPs. The potential pathwa...
Source: International Journal of Medical Sciences - May 10, 2021 Category: Biomedical Science Authors: Xin Wang Yaxin Shi Li Xu Zilu Wang Yanfei Wang Wei Shi Ke Ma Source Type: research

Postoperative pain assessment of robotic nipple-sparing mastectomy with immediate prepectoral prosthesis breast reconstruction: a comparison with conventional nipple-sparing mastectomy
Conclusions: Despite a statistical difference in the resting NRS scores during the early postoperative phase, the absence of any significant difference in the requirement of additional analgesics between the groups suggested that RNSM does not significantly attenuate postoperative pain intensity.PMID:33967619 | PMC:PMC8100638 | DOI:10.7150/ijms.56997 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - May 10, 2021 Category: Biomedical Science Authors: Jiae Moon Jeea Lee Dong Won Lee Hye Sun Lee Da Jung Nam Min Jung Kim Na Young Kim Hyung Seok Park Source Type: research

< em > Cedrus atlantica < /em > Extract Suppress Glioblastoma Growth through Promotion of Genotoxicity and Apoptosis: < em > In Vitro < /em > and < em > In Vivo < /em > Studies
Int J Med Sci. 2021 Apr 22;18(11):2417-2430. doi: 10.7150/ijms.54468. eCollection 2021.ABSTRACTGlioblastoma (GBM) is the most common malignant primary brain tumor in humans, exhibiting highly infiltrative growth and drug resistance to conventional chemotherapy. Cedrus atlantica (CAt) extract has been shown to decrease postoperative pain and inhibit the growth of K562 leukemia cells. The aim of this study was to assess the anti-GBM activity and molecular mechanism of CAt extract in vitro and in vivo. The results showed that CAt extract greatly suppressed GBM cells both in vitro and in vivo and enhanced the survival rate in ...
Source: International Journal of Medical Sciences - May 10, 2021 Category: Biomedical Science Authors: Kai-Fu Chang Jinghua Tsai Chang Xiao-Fan Huang Ya-Chih Huang Chia-Yu Li Jun-Cheng Weng Chih-Yen Hsiao Hui-Ju Hsu Nu-Man Tsai Source Type: research

Leptin regulates OPG and RANKL expression in Gingival Fibroblasts and Tissues of Chronic Periodontitis Patients
Int J Med Sci. 2021 Apr 22;18(11):2431-2437. doi: 10.7150/ijms.56151. eCollection 2021.ABSTRACTObjective: Chronic periodontitis is a bone-destructive disease affecting periodontal support structures. Although leptin has a protective effect against periodontitis, the underlying mechanism remains unclear. Therefore, this study aimed to investigate the possible role of leptin by examining its relationship with OPG and RANKL in human gingival tissues obtained from patients with chronic periodontitis. Method: Twenty-two patients with chronic periodontitis were enrolled (10 with moderate periodontitis and 12 with severe periodon...
Source: International Journal of Medical Sciences - May 10, 2021 Category: Biomedical Science Authors: Yiting Guo Chunjiao Xu Xiaoshan Wu Wenrui Zhang Yumei Sun Alisha Shrestha Source Type: research

Circular RNAs in stem cell differentiation: a sponge-like role for miRNAs
In conclusion, circRNAs regulate the stem cells differentiation via their ambient binding efficacy to modulate miRNA expression, as well as related gene translation. We believe that this review will provide reference guidance for future studies on stem cell differentiation.PMID:33967622 | PMC:PMC8100645 | DOI:10.7150/ijms.56457 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - May 10, 2021 Category: Biomedical Science Authors: Jian Zhou Cheng Qiu Zhihua Fan Tianyi Liu Tang Liu Source Type: research

Correlations among Pulmonary DJ-1, VDR and Nrf-2 in patients with Chronic Obstructive Pulmonary Disease: A Case-control Study
In conclusion, DJ-1, VDR and Nrf-2 were decreased in COPD patients compared with control subjects. The reduction of DJ-1 and VDR associating with Nrf-2 downregulation may be involved in the process of COPD.PMID:33967623 | PMC:PMC8100631 | DOI:10.7150/ijms.58452 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - May 10, 2021 Category: Biomedical Science Authors: Ying Xiang Lin Fu Hui-Xian Xiang Ling Zheng Zhu-Xia Tan Li-Xiang Wang Wei Cao De-Xiang Xu Hui Zhao Source Type: research

The impact of Aurora kinase A genetic polymorphisms on cervical cancer progression and clinicopathologic characteristics
In conclusion, tumor size and pelvic lymph node status rather than AURKA SNPs were the most obvious independent parameter that could significantly predict 5 years survival rate in Taiwanese women with cervical cancer.PMID:33967624 | PMC:PMC8100634 | DOI:10.7150/ijms.58516 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - May 10, 2021 Category: Biomedical Science Authors: Pei-Ju Wu Chun-Hao Wang Ming-Hong Hsieh Chung-Yuan Lee Po-Hui Wang Chiao-Wen Lin Shun-Fa Yang Maw-Sheng Lee Source Type: research