The Molecular Genetics of Marfan Syndrome
Int J Med Sci. 2021 May 27;18(13):2752-2766. doi: 10.7150/ijms.60685. eCollection 2021.ABSTRACTMarfan syndrome (MFS) is a complex connective tissue disease that is primarily characterized by cardiovascular, ocular and skeletal systems disorders. Despite its rarity, MFS severely impacts the quality of life of the patients. It has been shown that molecular genetic factors serve critical roles in the pathogenesis of MFS. FBN1 is associated with MFS and the other genes such as FBN2, transforming growth factor beta (TGF-β) receptors (TGFBR1 and TGFBR2), latent TGF-β-binding protein 2 (LTBP2) and SKI, amongst others al...
Source: International Journal of Medical Sciences - July 5, 2021 Category: Biomedical Science Authors: Qiu Du Dingding Zhang Yue Zhuang Qiongrong Xia Taishen Wen Haiping Jia Source Type: research

Exercise capacity, cardiovascular and metabolic risk of the sample of German police officers in a descriptive international comparison
Conclusions: To our knowledge, this study was one of the first to assess data on cardiovascular health, metabolic syndrome and cardiorespiratory status of police officers in Germany. The results of our study demonstrated an increased cardiovascular and metabolic risk and decreased cardiorespiratory fitness in German police officers. The present study results underline the need to implement health-promoting interventions and concepts like corporate sports activities or nutrition courses to counteract cardiovascular and metabolic risk factors. We have to reduce the subsequent development of cardiovascular and metabolic disea...
Source: International Journal of Medical Sciences - July 5, 2021 Category: Biomedical Science Authors: Markus Strauss Peter Foshag Ulrich Jehn Richard Vollenberg Anna Brz ęk Roman Leischik Source Type: research

Frequency of lower extremity artery disease in type 2 diabetic patients using pulse oximetry and the ankle-brachial index
Conclusions: We conclude that pulse oximetry is not useful in the screening for asymptomatic lower extremity artery disease in type 2 diabetics.PMID:34220305 | PMC:PMC8241790 | DOI:10.7150/ijms.58907 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - July 5, 2021 Category: Biomedical Science Authors: Mosquera-Fern ández Abián Balboa-Barreiro Vanesa Bellido-Guerrero Diego Gonz ález-Sagrado Manuel Vale-Carrodeguas Maria Veiga-Seijo Raquel Gonz ález-Martín Cristina Source Type: research

Effect of Ambulance Stretcher Bed Height Adjustment on CPR Quality and Rescuer Fatigue in a Laboratory Environment
Int J Med Sci. 2021 May 27;18(13):2783-2788. doi: 10.7150/ijms.59037. eCollection 2021.ABSTRACTBackground: The quality of cardiopulmonary resuscitation (CPR) is closely related to the survival rate of a patient, and it is crucial to maintain the quality of CPR during the ambulance journey to the receiving hospital. The purpose of this study was to investigate the effects of different stretcher bed heights on operator CPR quality. Methods: In this randomized crossover trial, 16 male emergency medical technicians-paramedics (EMT-Ps) performed continuous chest compressions on a hemimorphic mannequin for 5 minutes, alternating...
Source: International Journal of Medical Sciences - July 5, 2021 Category: Biomedical Science Authors: Chun-Sheng Ho Yi-Ju Hsu Fang Li Chien-Ching Tang Cheng-Pang Yang Chi-Chang Huang Chin-Shan Ho Chun-Hao Chang Source Type: research

Multi-biomarker is an early-stage predictor for progression of Coronavirus disease 2019 (COVID-19) infection
Int J Med Sci. 2021 May 27;18(13):2789-2798. doi: 10.7150/ijms.58742. eCollection 2021.ABSTRACTCoronavirus disease 2019 (COVID-19) has spread widely in the communities in many countries. Although most of the mild patients could be cured by their body's ability to self-heal, many patients quickly progressed to severe disease and had to undergo treatment in the intensive care unit (ICU). Thus, it is very important to effectively predict which patients with mild disease are more likely to progress to severe disease. A total of 72 patients hospitalized with COVID-19 in Shandong Provincial Public Health Clinical Center and 1141...
Source: International Journal of Medical Sciences - July 5, 2021 Category: Biomedical Science Authors: Zheng Zhou Ying Li Yuanhui Ma Heng Zhang Yunfeng Deng Zuobin Zhu Source Type: research

Targeted therapy for intervertebral disc degeneration: inhibiting apoptosis is a promising treatment strategy
This article mainly summarizes the factors that induce IDD and apoptosis, the relationship between the three apoptotic pathways and IDD, and potential therapeutic strategies. Preliminary animal and cell experiments show that targeting apoptotic pathway genes or drug inhibition can effectively inhibit IVD cell apoptosis and slow IDD progression. Targeted apoptotic pathway inhibition may be an effective strategy to alleviate IDD at the gene level. This manuscript provides new insights and ideas for IDD therapy.PMID:34220308 | PMC:PMC8241771 | DOI:10.7150/ijms.59171 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - July 5, 2021 Category: Biomedical Science Authors: Xiao-Bo Zhang Yi-Cun Hu Peng Cheng Hai-Yu Zhou Xiang-Yi Chen Ding Wu Rui-Hao Zhang De-Chen Yu Xi-Dan Gao Jin-Tao Shi Kai Zhang Shao-Long Li Peng-Jie Song Ke-Ping Wang Source Type: research

Abnormal proinflammatory and stressor environmental with increased the regulatory cellular IGF-1/PAPP-A/STC and Wnt-1/ β-Catenin canonical pathway in placenta of women with Chronic venous Disease during Pregnancy
Int J Med Sci. 2021 May 27;18(13):2814-2827. doi: 10.7150/ijms.58992. eCollection 2021.ABSTRACTLower limbs venous insufficiency refers to a wide variety of venous disorders grouped by the term of chronic venous disease (CVD). Hemodynamic and hormonal changes related to pregnancy period, may promote the development of CVD affecting approximately 1 in 3 women. It has been shown that the presence of this condition is associated with damage and placental suffering. Thus, taking IGF-1/PAPP-A/STC-2, inflammatory cytokines production, PI3K/Akt and Wnt/ β-catenin pathways as a part of the alterations that occurs in the placen...
Source: International Journal of Medical Sciences - July 5, 2021 Category: Biomedical Science Authors: Miguel A Ortega Oscar Fraile-Mart ínez Miguel A Saez Miguel A Álvarez-Mon Ana M G ómez-Lahoz Coral Bravo Juan A De Le ón Luis Felipe Sainz Santiago Coca Ángel Asúnsolo Jorge Monserrat Luis G Guijarro Melchor Álvarez-Mon Julia Bujan Natalio Garc ía Source Type: research

Prediction of lymphovascular space invasion in patients with endometrial cancer
Int J Med Sci. 2021 Jun 1;18(13):2828-2834. doi: 10.7150/ijms.60718. eCollection 2021.ABSTRACTObjective: Predict the presence of lymphovascular space invasion (LVSI), using uterine factors such as tumor diameter (TD), grade, and depth of myometrial invasion (MMI). Develop a predictive model that could serve as a marker of LVSI in women with endometrial cancer (EC). Methods: Data from 888 patients with endometrioid EC who were treated between January 2009 and December 2018 were reviewed. The patients' data were retrieved from six institutions. We assessed the differences in the clinicopathological characteristics between pa...
Source: International Journal of Medical Sciences - July 5, 2021 Category: Biomedical Science Authors: Sang Il Kim Joo Hee Yoon Sung Jong Lee Min Jong Song Jin Hwi Kim Hae Nam Lee Gyul Jung Ji Geun Yoo Source Type: research

< em > Salmonella < /em > reduces tumor metastasis by downregulation C-X-C chemokine receptor type 4
Int J Med Sci. 2021 Jun 1;18(13):2835-2841. doi: 10.7150/ijms.60439. eCollection 2021.ABSTRACTTumor metastasis is the main reason for the death of most cancer patients. C-X-C chemokine receptor type 4 (CXCR4) has been demonstrated to be overexpressed in numerous types of cancer. CXCR4 selectively binds with stromal cell-derived factor 1 (SDF1), also known as C-X-C family chemokine ligand 12 (CXCL12) (CXCL12/SDF-1), which induced tumor proliferation and metastasis. Recently, the use of conventional cancer treatments had some limitation; bacteria treatment for cancer becomes a trend that overcomes these limitations. Plenty o...
Source: International Journal of Medical Sciences - July 5, 2021 Category: Biomedical Science Authors: Tai-Huang Lee Gaun-You Lin Ming-Hui Yang Yu-Chang Tyan Che-Hsin Lee Source Type: research

Effects of renal impairment on cardiac remodeling and clinical outcomes after myocardial infarction
This study evaluated the impact of levels of renal impairment on drug therapy, echocardiographic parameters, and outcomes in patients with AMI undergoing percutaneous coronary intervention (PCI). A total of 611 patients diagnosed with AMI underwent successful PCI, and two echocardiographic examinations were performed within 1 year after AMI. Patients were categorized according to Group 1: severely impaired estimated glomerular filtration rate (eGFR)
Source: International Journal of Medical Sciences - July 5, 2021 Category: Biomedical Science Authors: Chun-Yen Chiang Sheng-Chung Huang Michael Chen Jhih-Yuan Shih Chon-Seng Hong Nan-Chun Wu Chung-Han Ho Chia Chun Wu Zhih-Cherng Chen Wei-Ting Chang Source Type: research

Clinical applications of mesenchymal stromal cell-based therapies for pulmonary diseases: An Update and Concise Review
Int J Med Sci. 2021 Jun 1;18(13):2849-2870. doi: 10.7150/ijms.59218. eCollection 2021.ABSTRACTLung disorders are a leading cause of morbidity and death worldwide. For many disease conditions, no effective and curative treatment options are available. Mesenchymal stromal cell (MSC)-based therapy is one of the cutting-edge topics in medical research today. It offers a novel and promising therapeutic option for various acute and chronic lung diseases due to its potent and broad-ranging immunomodulatory activities, bacterial clearance, tissue regeneration, and proangiogenic and antifibrotic properties, which rely on both cell-...
Source: International Journal of Medical Sciences - July 5, 2021 Category: Biomedical Science Authors: Xiaobo Chen Feng Wang Zhiwei Huang Yan Wu Jie Geng Yuliang Wang Source Type: research

Artificial Intelligence and Machine Learning in Chronic Airway Diseases: Focus on Asthma and Chronic Obstructive Pulmonary Disease
Int J Med Sci. 2021 Jun 1;18(13):2871-2889. doi: 10.7150/ijms.58191. eCollection 2021.ABSTRACTChronic airway diseases are characterized by airway inflammation, obstruction, and remodeling and show high prevalence, especially in developing countries. Among them, asthma and chronic obstructive pulmonary disease (COPD) show the highest morbidity and socioeconomic burden worldwide. Although there are extensive guidelines for the prevention, early diagnosis, and rational treatment of these lifelong diseases, their value in precision medicine is very limited. Artificial intelligence (AI) and machine learning (ML) techniques have...
Source: International Journal of Medical Sciences - July 5, 2021 Category: Biomedical Science Authors: Yinhe Feng Yubin Wang Chunfang Zeng Hui Mao Source Type: research

Role of Unfolded Protein Response and Endoplasmic Reticulum-Associated Degradation by Repeated Exposure to Inhalation Anesthetics in < em > Caenorhabditis elegans < /em >
Conclusion: Repeated isoflurane exposure caused significant ER stress in C. elegans. Following the increase in UPR, the ERAD pathway was disrupted by repeated isoflurane exposure and ubiquitinated proteins was accumulated subsequently. UPR and ERAD pathways are potential modifiable neuroprotection targets against anesthesia-induced neurotoxicity.PMID:34220315 | PMC:PMC8241789 | DOI:10.7150/ijms.58043 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - July 5, 2021 Category: Biomedical Science Authors: Saeyeon Kim Hyun-Jung Shin Sang-Hwan Do Hyo-Seok Na Source Type: research

Evaluation of atherogenic lipoprotein-cholesterol to HDL cholesterol ratio as a prognostic test for ST-segment elevation myocardial infarction
In this study, we evaluated the hypothesis that atherogenic lipoprotein-cholesterol (AL-c), representing the sum of RLP-c and the sd-LDL-c, to the HDL-c ratio, could represent a better predictive indicator than RLP-c alone in ST-segment elevation myocardial infarction (STEMI). Methods: The 316 consecutive patients suffering from persistent chest discomfort admitted to the Shanghai General Hospital between January 2018 and June 2018 were enrolled. 149 STEMI patients (62% men, mean age 69.6 ± 13.3 years) were included as the study cohort. The AL-c/HDL-c ratio was calculated on admission in a cohort of electrocardiogra...
Source: International Journal of Medical Sciences - July 5, 2021 Category: Biomedical Science Authors: Jia-Yong Li Wen-Jun Xu Zhe Zhou Ru-Lin Zhang Ting Sun Hao Xu Jun Wu Source Type: research

Association of QRS-T angle and Late Gadolinium Enhancement in patients with a Clinical Suspicion of Myocarditis
Int J Med Sci. 2021 Jun 4;18(13):2905-2909. doi: 10.7150/ijms.57010. eCollection 2021.ABSTRACTObjective: To investigate the association of a wide QRS-T angle on the surface ECG and late gadolinium enhancement on contrast-enhanced cardiovascular magnetic (CMR) imaging in patients with clinically suspected myocarditis. Background: Diagnosis and risk stratification in patients with suspected myocarditis is particularly challenging due to a great spectrum of clinical presentations. Late gadolinium enhancement (LGE) visualizes myocardial necrosis and fibrosis in patients with biopsy-proven myocarditis. The presence or absence o...
Source: International Journal of Medical Sciences - July 5, 2021 Category: Biomedical Science Authors: C J Jensen B Zadeh J M Wambach M Lambers K Nassenstein O Bruder Source Type: research

Effect of MT2A on apoptosis and proliferation in HL60 cells
Int J Med Sci. 2021 Jun 4;18(13):2910-2919. doi: 10.7150/ijms.57821. eCollection 2021.ABSTRACTAlthough accumulating evidence has revealed that metallothioneins (MTs) and its family member MT2A are strongly linked to the risk of various solid tumors, researches on the occurrence and development of acute myeloid leukemia (AML) have rarely been investigated. Here, we constructed a lentiviral vector with MT2A over-expression and the interfering plasmids with MT2A expression inhibition to study the influence of MT2A on the bioactivities of HL60 cells. After cells were infected with a lentiviral vector containing the MT2A gene, ...
Source: International Journal of Medical Sciences - July 5, 2021 Category: Biomedical Science Authors: Yu-Qing Pan Min Niu Shu-Min Liu Yu-Xia Bao Kai Yang Xiao-Bo Ma Liang He Yi-Xun Li Jie-Xian Cao Xi Zhang Yan Du Source Type: research

Selective brain cooling achieves peripheral organs protection in hemorrhagic shock resuscitation via preserving the integrity of the brain-gut axis
Conclusion: Resuscitation with selective brain cooling achieves peripheral vital organs protection in hemorrhagic shock resuscitation via preserving the integrity of the brain-gut axis.PMID:34220319 | PMC:PMC8241763 | DOI:10.7150/ijms.61191 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - July 5, 2021 Category: Biomedical Science Authors: Chien-Ming Chao Chien-Chin Hsu Chien-Cheng Huang Chung-Han Wang Mao-Tsun Lin Ching-Ping Chang Hung-Jung Lin Chung-Ching Chio Source Type: research

Enhancement of cytotoxicity and induction of apoptosis by cationic nano-liposome formulation of < em > n < /em > -butylidenephthalide in breast cancer cells
In conclusion, BP exhibited an anti-cancer effect on breast cancer cells, and LPPC encapsulation efficiently improved the cytotoxicity of BP via an acceleration of entrapment efficiency to induce cell cycle block and apoptosis. Furthermore, BP/LPPC exhibited a synergistic effect in combination with doxorubicin.PMID:34220320 | PMC:PMC8241786 | DOI:10.7150/ijms.51439 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - July 5, 2021 Category: Biomedical Science Authors: Xiao-Fan Huang Kai-Fu Chang Yu-Ling Lin Kuang-Wen Liao Chih-Yen Hsiao Gwo-Tarng Sheu Nu-Man Tsai Source Type: research

Designing Nanoparticle-based Drug Delivery Systems for Precision Medicine
Int J Med Sci. 2021 Jun 5;18(13):2943-2949. doi: 10.7150/ijms.60874. eCollection 2021.ABSTRACTTraditional drugs are facing bottlenecks of lower solubility, absorption, and especially the inefficient organs or cells targeting during the precision medicine era. It is urgently needed to discover and establish new methods or strategies to modify old drugs or create new ones against the above defects. With the support of nanotechnology, the solubility, absorption and targeting of traditional drugs were greatly improved by modifying and fabricating with various types of nanoparticles to some extent, though many shortages remain....
Source: International Journal of Medical Sciences - July 5, 2021 Category: Biomedical Science Authors: Jianhua Yang Chengyou Jia Jianshe Yang Source Type: research

Distinct Patterns of Brain Atrophy associated with Mild Behavioral Impairment in Cognitively Normal Elderly Adults
Int J Med Sci. 2021 Jun 11;18(13):2950-2956. doi: 10.7150/ijms.60810. eCollection 2021.ABSTRACTA cross-sectional study was conducted to evaluate patterns of gray matter changes in cognitively normal elderly adults with mild behavioral impairment (MBI). Sixteen MBI patients and 18 healthy controls were selected. All the participants underwent a neuropsychological assessment battery, including the Mini-mental State Examination (MMSE), Geriatric Depression Scale (GDS), Self-rating Anxiety Scale (SAS), and Chinese version of the mild behavioral impairment-checklist scale (MBI-C), and magnetic resonance imaging (MRI) scans. Ima...
Source: International Journal of Medical Sciences - July 5, 2021 Category: Biomedical Science Authors: Jun Shu Qiang Qiang Yuning Yan Yang Wen Yiqing Ren Wenshi Wei Li Zhang Source Type: research

Factors associated with Successful Responses to Ganglion Impar Block: A Retrospective Study
Conclusion: Ganglion impar block may be more effective in cancer-related pain than pain due to benign causes.PMID:34220323 | PMC:PMC8241784 | DOI:10.7150/ijms.60962 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - July 5, 2021 Category: Biomedical Science Authors: Chan-Sik Kim Kyounghwan Jang Jeong-Gil Leem Jin-Woo Shin Doo-Hwan Kim Seong-Soo Choi Source Type: research

Lower serum bilirubin is associated with poor renal outcome in IgA nephropathy patients
Int J Med Sci. 2021 Jun 11;18(13):2964-2970. doi: 10.7150/ijms.60111. eCollection 2021.ABSTRACTAims: IgA nephropathy (IgAN) is the most prevalent primary glomerulonephritis worldwide. We conducted this study to explore the relationship between serum bilirubin and renal outcome of patients with IgAN. Methods: A total of 1492 biopsy proven IgAN patients were recruited and divided into two groups according to their median serum bilirubin concentration: the low bilirubin group (serum bilirubin≤9.7umol/L, n=753) and high bilirubin group (serum bilirubin>9.7umol/L, n=739). Basic clinical characteristics were assessed at th...
Source: International Journal of Medical Sciences - July 5, 2021 Category: Biomedical Science Authors: Zheng Jiang Jiaxing Tan Siqing Wang Lingqiu Dong Xin Han Yi Tang Wei Qin Source Type: research

Efficacy of bisphosphonates in detection of early enamel caries using NIR fluorescence imaging and inhibition of caries progression
This study assessed diagnostic accuracy of caries detection by NIR fluorescence imaging with OsteoSense 750® (OS750) in vitro and ex vivo, and to analyze the therapeutic efficacy of a bisphosphonate (Etidronate) in inhibiting enamel caries progression in vitro. Methods: Four experiments were conducted using extracted human teeth; 1) to calculate the infiltration rate of OS750 into interproximal white spot lesions using fluorescence microscope, 2) to assess diagnostic accuracy of interproximal natural white spot lesions using desktop NIR fluorescence imaging device in vitro setting, 3) to assess diagnostic accuracy of a...
Source: International Journal of Medical Sciences - July 5, 2021 Category: Biomedical Science Authors: Jie Sun Mindy Gil Shahrzad Khorashadi George Chen Cliff Lee Yoshiki Ishida Masazumi Nagai Shinichiro Wada Shigemi Ishikawa-Nagai John D Da Silva Source Type: research

< em > Salmonella < /em > alters heparanase expression and reduces tumor metastasis
Int J Med Sci. 2021 Jun 11;18(13):2981-2989. doi: 10.7150/ijms.60281. eCollection 2021.ABSTRACTSalmonella causes salmonellosis, is a facultative anaerobe and is one of the common Gram-negative bacteria. Salmonella has anti-tumor potential and tumor-targeting activity. The heparin sulfate on cell surfaces can be cleaved by heparanase that is an endo-β-D-glucuronidase. Heparanase can destroy the extracellular matrix and is involved in tumor metastasis and angiogenic activity. Previously, Salmonella was demonstrated to inhibit tumor metastasis. It remains unclear whether Salmonella inhibits metastasis by regulating hepar...
Source: International Journal of Medical Sciences - July 5, 2021 Category: Biomedical Science Authors: Huan-Min Chiu Wen-Yi Chiou Wei-Jie Hsu Li-Hsien Wu Ming-Hui Yang Yu-Chang Tyan Che-Hsin Lee Source Type: research

Determination of Bioelectrical Impedance Thresholds for Early Detection of Breast Cancer-related Lymphedema
Conclusions: We determined the Youden index-based cutoff points, mean + 2SD and mean + 3SD values of the ECF, ECW, as well as SFBIA ratios at 1 and 5 kHz for both dominant and nondominant arms with data from 1305 healthy subjects. Next, the Youden index-based cutoff points, the mean + 2SD and mean + 3SD values were used to recognize patients with lymphedema. We found that the Youden index-based cutoff points and the mean + 2SD showed similar identification capacity on lymphedema, and they seemed to distinguish more patients with lymphedema than mean + 3SD values.PMID:34220327 | PMC:PMC8241780 | DOI:10.7150/ijms.53812 (Sour...
Source: International Journal of Medical Sciences - July 5, 2021 Category: Biomedical Science Authors: Siyao Liu Quanping Zhao Xinmei Ren Ying Cui Houpu Yang Siyuan Wang Miao Liu Shu Wang Source Type: research

TRIM21 Polymorphisms are associated with Susceptibility and Clinical Status of Oral Squamous Cell Carcinoma patients
This study is the first to examine the risk factors associated with TRIM21 SNPs in OSCC progression and development. Thus, our findings suggest that this study is the first to examine the risk factors associated with TRIM21 SNPs in OSCC progression and development and suggest that interactions between mutant genes may alter the susceptibility to OSCC.PMID:34220328 | PMC:PMC8241778 | DOI:10.7150/ijms.56614 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - July 5, 2021 Category: Biomedical Science Authors: Chun-Yi Chuang Yi-Chung Chien Chiao-Wen Lin Chia-Hsuan Chou Shuo-Chueh Chen Chun-Lin Liu Li-Yuan Bai Shun-Fa Yang Yung-Luen Yu Source Type: research

CD8 < sup > + < /sup > T cell survival in lethal fungal sepsis was ameliorated by T-cell-specific mTOR deletion
Int J Med Sci. 2021 Jun 16;18(13):3004-3013. doi: 10.7150/ijms.55592. eCollection 2021.ABSTRACTLethal fungal sepsis causes high morbidity and mortality in intensive care patients. Fungal infections have an immunological basis, and it has been shown in recent studies that decreased CD8+ T-cell count in fungal infections is related to prognosis, while the underlying mechanism is still unclear. Here, a lethal fungal sepsis model induced by candidemia was created and we found a decreased CD8+ T-cell count and exaggerated apoptosis. Simultaneously, expression of light chain (LC)3B in CD8+ T cells increased, along with increased...
Source: International Journal of Medical Sciences - July 5, 2021 Category: Biomedical Science Authors: Hao Wang Wen Han Ran Guo Guangxu Bai Jianwei Chen Na Cui Source Type: research

Experimental postoperative ileus: is Th2 immune response involved?
Conclusion: Th2 immune response can be involved in the activation of mast cells in POI, which was associated with ROS mediated activation of NF-κB and p38 MAPK signaling pathway.PMID:34220330 | PMC:PMC8241774 | DOI:10.7150/ijms.59354 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - July 5, 2021 Category: Biomedical Science Authors: Sisi Lin Florian K ühn Tobias S Schiergens Andrey A Zamyatnin Orkhan Isayev Eldar Gasimov Jens Werner Yongyu Li Alexandr V Bazhin Source Type: research

The underlying molecular mechanism and drugs for treatment in adrenal cortical carcinoma
Conclusion: The hub-genes expression was significant useful in adrenal cortical carcinoma, provide new diagnostic, prognosis and therapeutic approaches for adrenal cortical carcinoma. Furthermore, we also explore the possible miRNAs involved in regulation of hub-genes.PMID:34220331 | PMC:PMC8241782 | DOI:10.7150/ijms.60261 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - July 5, 2021 Category: Biomedical Science Authors: Chengquan Ma Jian Xiong Hao Su Hongjun Li Source Type: research

Antitumor Activity of Small Activating RNAs Induced PAWR Gene Activation in Human Bladder Cancer Cells
Int J Med Sci. 2021 Jun 16;18(13):3039-3049. doi: 10.7150/ijms.60399. eCollection 2021.ABSTRACTSmall double-stranded RNAs (dsRNAs) have been proved to effectively up-regulate the expression of particular genes by targeting their promoters. These small dsRNAs were also termed small activating RNAs (saRNAs). We previously reported that several small double-stranded RNAs (dsRNAs) targeting the PRKC apoptosis WT1 regulator (PAWR) promoter can up-regulate PAWR gene expression effectively in human cancer cells. The present study was conducted to evaluate the antitumor potential of PAWR gene induction by these saRNAs in bladder c...
Source: International Journal of Medical Sciences - July 5, 2021 Category: Biomedical Science Authors: Kai Yang Jie Shen Fu-Qing Tan Xiang-Yi Zheng Li-Ping Xie Source Type: research

The Molecular Genetics of Marfan Syndrome
Int J Med Sci. 2021 May 27;18(13):2752-2766. doi: 10.7150/ijms.60685. eCollection 2021.ABSTRACTMarfan syndrome (MFS) is a complex connective tissue disease that is primarily characterized by cardiovascular, ocular and skeletal systems disorders. Despite its rarity, MFS severely impacts the quality of life of the patients. It has been shown that molecular genetic factors serve critical roles in the pathogenesis of MFS. FBN1 is associated with MFS and the other genes such as FBN2, transforming growth factor beta (TGF-β) receptors (TGFBR1 and TGFBR2), latent TGF-β-binding protein 2 (LTBP2) and SKI, amongst others al...
Source: International Journal of Medical Sciences - July 5, 2021 Category: Biomedical Science Authors: Qiu Du Dingding Zhang Yue Zhuang Qiongrong Xia Taishen Wen Haiping Jia Source Type: research

Exercise capacity, cardiovascular and metabolic risk of the sample of German police officers in a descriptive international comparison
Conclusions: To our knowledge, this study was one of the first to assess data on cardiovascular health, metabolic syndrome and cardiorespiratory status of police officers in Germany. The results of our study demonstrated an increased cardiovascular and metabolic risk and decreased cardiorespiratory fitness in German police officers. The present study results underline the need to implement health-promoting interventions and concepts like corporate sports activities or nutrition courses to counteract cardiovascular and metabolic risk factors. We have to reduce the subsequent development of cardiovascular and metabolic disea...
Source: International Journal of Medical Sciences - July 5, 2021 Category: Biomedical Science Authors: Markus Strauss Peter Foshag Ulrich Jehn Richard Vollenberg Anna Brz ęk Roman Leischik Source Type: research

Frequency of lower extremity artery disease in type 2 diabetic patients using pulse oximetry and the ankle-brachial index
Conclusions: We conclude that pulse oximetry is not useful in the screening for asymptomatic lower extremity artery disease in type 2 diabetics.PMID:34220305 | PMC:PMC8241790 | DOI:10.7150/ijms.58907 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - July 5, 2021 Category: Biomedical Science Authors: Mosquera-Fern ández Abián Balboa-Barreiro Vanesa Bellido-Guerrero Diego Gonz ález-Sagrado Manuel Vale-Carrodeguas Maria Veiga-Seijo Raquel Gonz ález-Martín Cristina Source Type: research

Effect of Ambulance Stretcher Bed Height Adjustment on CPR Quality and Rescuer Fatigue in a Laboratory Environment
Int J Med Sci. 2021 May 27;18(13):2783-2788. doi: 10.7150/ijms.59037. eCollection 2021.ABSTRACTBackground: The quality of cardiopulmonary resuscitation (CPR) is closely related to the survival rate of a patient, and it is crucial to maintain the quality of CPR during the ambulance journey to the receiving hospital. The purpose of this study was to investigate the effects of different stretcher bed heights on operator CPR quality. Methods: In this randomized crossover trial, 16 male emergency medical technicians-paramedics (EMT-Ps) performed continuous chest compressions on a hemimorphic mannequin for 5 minutes, alternating...
Source: International Journal of Medical Sciences - July 5, 2021 Category: Biomedical Science Authors: Chun-Sheng Ho Yi-Ju Hsu Fang Li Chien-Ching Tang Cheng-Pang Yang Chi-Chang Huang Chin-Shan Ho Chun-Hao Chang Source Type: research

Multi-biomarker is an early-stage predictor for progression of Coronavirus disease 2019 (COVID-19) infection
Int J Med Sci. 2021 May 27;18(13):2789-2798. doi: 10.7150/ijms.58742. eCollection 2021.ABSTRACTCoronavirus disease 2019 (COVID-19) has spread widely in the communities in many countries. Although most of the mild patients could be cured by their body's ability to self-heal, many patients quickly progressed to severe disease and had to undergo treatment in the intensive care unit (ICU). Thus, it is very important to effectively predict which patients with mild disease are more likely to progress to severe disease. A total of 72 patients hospitalized with COVID-19 in Shandong Provincial Public Health Clinical Center and 1141...
Source: International Journal of Medical Sciences - July 5, 2021 Category: Biomedical Science Authors: Zheng Zhou Ying Li Yuanhui Ma Heng Zhang Yunfeng Deng Zuobin Zhu Source Type: research

Targeted therapy for intervertebral disc degeneration: inhibiting apoptosis is a promising treatment strategy
This article mainly summarizes the factors that induce IDD and apoptosis, the relationship between the three apoptotic pathways and IDD, and potential therapeutic strategies. Preliminary animal and cell experiments show that targeting apoptotic pathway genes or drug inhibition can effectively inhibit IVD cell apoptosis and slow IDD progression. Targeted apoptotic pathway inhibition may be an effective strategy to alleviate IDD at the gene level. This manuscript provides new insights and ideas for IDD therapy.PMID:34220308 | PMC:PMC8241771 | DOI:10.7150/ijms.59171 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - July 5, 2021 Category: Biomedical Science Authors: Xiao-Bo Zhang Yi-Cun Hu Peng Cheng Hai-Yu Zhou Xiang-Yi Chen Ding Wu Rui-Hao Zhang De-Chen Yu Xi-Dan Gao Jin-Tao Shi Kai Zhang Shao-Long Li Peng-Jie Song Ke-Ping Wang Source Type: research

Abnormal proinflammatory and stressor environmental with increased the regulatory cellular IGF-1/PAPP-A/STC and Wnt-1/ β-Catenin canonical pathway in placenta of women with Chronic venous Disease during Pregnancy
Int J Med Sci. 2021 May 27;18(13):2814-2827. doi: 10.7150/ijms.58992. eCollection 2021.ABSTRACTLower limbs venous insufficiency refers to a wide variety of venous disorders grouped by the term of chronic venous disease (CVD). Hemodynamic and hormonal changes related to pregnancy period, may promote the development of CVD affecting approximately 1 in 3 women. It has been shown that the presence of this condition is associated with damage and placental suffering. Thus, taking IGF-1/PAPP-A/STC-2, inflammatory cytokines production, PI3K/Akt and Wnt/ β-catenin pathways as a part of the alterations that occurs in the placen...
Source: International Journal of Medical Sciences - July 5, 2021 Category: Biomedical Science Authors: Miguel A Ortega Oscar Fraile-Mart ínez Miguel A Saez Miguel A Álvarez-Mon Ana M G ómez-Lahoz Coral Bravo Juan A De Le ón Luis Felipe Sainz Santiago Coca Ángel Asúnsolo Jorge Monserrat Luis G Guijarro Melchor Álvarez-Mon Julia Bujan Natalio Garc ía Source Type: research

Prediction of lymphovascular space invasion in patients with endometrial cancer
Int J Med Sci. 2021 Jun 1;18(13):2828-2834. doi: 10.7150/ijms.60718. eCollection 2021.ABSTRACTObjective: Predict the presence of lymphovascular space invasion (LVSI), using uterine factors such as tumor diameter (TD), grade, and depth of myometrial invasion (MMI). Develop a predictive model that could serve as a marker of LVSI in women with endometrial cancer (EC). Methods: Data from 888 patients with endometrioid EC who were treated between January 2009 and December 2018 were reviewed. The patients' data were retrieved from six institutions. We assessed the differences in the clinicopathological characteristics between pa...
Source: International Journal of Medical Sciences - July 5, 2021 Category: Biomedical Science Authors: Sang Il Kim Joo Hee Yoon Sung Jong Lee Min Jong Song Jin Hwi Kim Hae Nam Lee Gyul Jung Ji Geun Yoo Source Type: research

< em > Salmonella < /em > reduces tumor metastasis by downregulation C-X-C chemokine receptor type 4
Int J Med Sci. 2021 Jun 1;18(13):2835-2841. doi: 10.7150/ijms.60439. eCollection 2021.ABSTRACTTumor metastasis is the main reason for the death of most cancer patients. C-X-C chemokine receptor type 4 (CXCR4) has been demonstrated to be overexpressed in numerous types of cancer. CXCR4 selectively binds with stromal cell-derived factor 1 (SDF1), also known as C-X-C family chemokine ligand 12 (CXCL12) (CXCL12/SDF-1), which induced tumor proliferation and metastasis. Recently, the use of conventional cancer treatments had some limitation; bacteria treatment for cancer becomes a trend that overcomes these limitations. Plenty o...
Source: International Journal of Medical Sciences - July 5, 2021 Category: Biomedical Science Authors: Tai-Huang Lee Gaun-You Lin Ming-Hui Yang Yu-Chang Tyan Che-Hsin Lee Source Type: research

Effects of renal impairment on cardiac remodeling and clinical outcomes after myocardial infarction
This study evaluated the impact of levels of renal impairment on drug therapy, echocardiographic parameters, and outcomes in patients with AMI undergoing percutaneous coronary intervention (PCI). A total of 611 patients diagnosed with AMI underwent successful PCI, and two echocardiographic examinations were performed within 1 year after AMI. Patients were categorized according to Group 1: severely impaired estimated glomerular filtration rate (eGFR)
Source: International Journal of Medical Sciences - July 5, 2021 Category: Biomedical Science Authors: Chun-Yen Chiang Sheng-Chung Huang Michael Chen Jhih-Yuan Shih Chon-Seng Hong Nan-Chun Wu Chung-Han Ho Chia Chun Wu Zhih-Cherng Chen Wei-Ting Chang Source Type: research

Clinical applications of mesenchymal stromal cell-based therapies for pulmonary diseases: An Update and Concise Review
Int J Med Sci. 2021 Jun 1;18(13):2849-2870. doi: 10.7150/ijms.59218. eCollection 2021.ABSTRACTLung disorders are a leading cause of morbidity and death worldwide. For many disease conditions, no effective and curative treatment options are available. Mesenchymal stromal cell (MSC)-based therapy is one of the cutting-edge topics in medical research today. It offers a novel and promising therapeutic option for various acute and chronic lung diseases due to its potent and broad-ranging immunomodulatory activities, bacterial clearance, tissue regeneration, and proangiogenic and antifibrotic properties, which rely on both cell-...
Source: International Journal of Medical Sciences - July 5, 2021 Category: Biomedical Science Authors: Xiaobo Chen Feng Wang Zhiwei Huang Yan Wu Jie Geng Yuliang Wang Source Type: research

Artificial Intelligence and Machine Learning in Chronic Airway Diseases: Focus on Asthma and Chronic Obstructive Pulmonary Disease
Int J Med Sci. 2021 Jun 1;18(13):2871-2889. doi: 10.7150/ijms.58191. eCollection 2021.ABSTRACTChronic airway diseases are characterized by airway inflammation, obstruction, and remodeling and show high prevalence, especially in developing countries. Among them, asthma and chronic obstructive pulmonary disease (COPD) show the highest morbidity and socioeconomic burden worldwide. Although there are extensive guidelines for the prevention, early diagnosis, and rational treatment of these lifelong diseases, their value in precision medicine is very limited. Artificial intelligence (AI) and machine learning (ML) techniques have...
Source: International Journal of Medical Sciences - July 5, 2021 Category: Biomedical Science Authors: Yinhe Feng Yubin Wang Chunfang Zeng Hui Mao Source Type: research

Role of Unfolded Protein Response and Endoplasmic Reticulum-Associated Degradation by Repeated Exposure to Inhalation Anesthetics in < em > Caenorhabditis elegans < /em >
Conclusion: Repeated isoflurane exposure caused significant ER stress in C. elegans. Following the increase in UPR, the ERAD pathway was disrupted by repeated isoflurane exposure and ubiquitinated proteins was accumulated subsequently. UPR and ERAD pathways are potential modifiable neuroprotection targets against anesthesia-induced neurotoxicity.PMID:34220315 | PMC:PMC8241789 | DOI:10.7150/ijms.58043 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - July 5, 2021 Category: Biomedical Science Authors: Saeyeon Kim Hyun-Jung Shin Sang-Hwan Do Hyo-Seok Na Source Type: research

Evaluation of atherogenic lipoprotein-cholesterol to HDL cholesterol ratio as a prognostic test for ST-segment elevation myocardial infarction
In this study, we evaluated the hypothesis that atherogenic lipoprotein-cholesterol (AL-c), representing the sum of RLP-c and the sd-LDL-c, to the HDL-c ratio, could represent a better predictive indicator than RLP-c alone in ST-segment elevation myocardial infarction (STEMI). Methods: The 316 consecutive patients suffering from persistent chest discomfort admitted to the Shanghai General Hospital between January 2018 and June 2018 were enrolled. 149 STEMI patients (62% men, mean age 69.6 ± 13.3 years) were included as the study cohort. The AL-c/HDL-c ratio was calculated on admission in a cohort of electrocardiogra...
Source: International Journal of Medical Sciences - July 5, 2021 Category: Biomedical Science Authors: Jia-Yong Li Wen-Jun Xu Zhe Zhou Ru-Lin Zhang Ting Sun Hao Xu Jun Wu Source Type: research

Association of QRS-T angle and Late Gadolinium Enhancement in patients with a Clinical Suspicion of Myocarditis
Int J Med Sci. 2021 Jun 4;18(13):2905-2909. doi: 10.7150/ijms.57010. eCollection 2021.ABSTRACTObjective: To investigate the association of a wide QRS-T angle on the surface ECG and late gadolinium enhancement on contrast-enhanced cardiovascular magnetic (CMR) imaging in patients with clinically suspected myocarditis. Background: Diagnosis and risk stratification in patients with suspected myocarditis is particularly challenging due to a great spectrum of clinical presentations. Late gadolinium enhancement (LGE) visualizes myocardial necrosis and fibrosis in patients with biopsy-proven myocarditis. The presence or absence o...
Source: International Journal of Medical Sciences - July 5, 2021 Category: Biomedical Science Authors: C J Jensen B Zadeh J M Wambach M Lambers K Nassenstein O Bruder Source Type: research

Effect of MT2A on apoptosis and proliferation in HL60 cells
Int J Med Sci. 2021 Jun 4;18(13):2910-2919. doi: 10.7150/ijms.57821. eCollection 2021.ABSTRACTAlthough accumulating evidence has revealed that metallothioneins (MTs) and its family member MT2A are strongly linked to the risk of various solid tumors, researches on the occurrence and development of acute myeloid leukemia (AML) have rarely been investigated. Here, we constructed a lentiviral vector with MT2A over-expression and the interfering plasmids with MT2A expression inhibition to study the influence of MT2A on the bioactivities of HL60 cells. After cells were infected with a lentiviral vector containing the MT2A gene, ...
Source: International Journal of Medical Sciences - July 5, 2021 Category: Biomedical Science Authors: Yu-Qing Pan Min Niu Shu-Min Liu Yu-Xia Bao Kai Yang Xiao-Bo Ma Liang He Yi-Xun Li Jie-Xian Cao Xi Zhang Yan Du Source Type: research

Selective brain cooling achieves peripheral organs protection in hemorrhagic shock resuscitation via preserving the integrity of the brain-gut axis
Conclusion: Resuscitation with selective brain cooling achieves peripheral vital organs protection in hemorrhagic shock resuscitation via preserving the integrity of the brain-gut axis.PMID:34220319 | PMC:PMC8241763 | DOI:10.7150/ijms.61191 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - July 5, 2021 Category: Biomedical Science Authors: Chien-Ming Chao Chien-Chin Hsu Chien-Cheng Huang Chung-Han Wang Mao-Tsun Lin Ching-Ping Chang Hung-Jung Lin Chung-Ching Chio Source Type: research

Enhancement of cytotoxicity and induction of apoptosis by cationic nano-liposome formulation of < em > n < /em > -butylidenephthalide in breast cancer cells
In conclusion, BP exhibited an anti-cancer effect on breast cancer cells, and LPPC encapsulation efficiently improved the cytotoxicity of BP via an acceleration of entrapment efficiency to induce cell cycle block and apoptosis. Furthermore, BP/LPPC exhibited a synergistic effect in combination with doxorubicin.PMID:34220320 | PMC:PMC8241786 | DOI:10.7150/ijms.51439 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - July 5, 2021 Category: Biomedical Science Authors: Xiao-Fan Huang Kai-Fu Chang Yu-Ling Lin Kuang-Wen Liao Chih-Yen Hsiao Gwo-Tarng Sheu Nu-Man Tsai Source Type: research

Designing Nanoparticle-based Drug Delivery Systems for Precision Medicine
Int J Med Sci. 2021 Jun 5;18(13):2943-2949. doi: 10.7150/ijms.60874. eCollection 2021.ABSTRACTTraditional drugs are facing bottlenecks of lower solubility, absorption, and especially the inefficient organs or cells targeting during the precision medicine era. It is urgently needed to discover and establish new methods or strategies to modify old drugs or create new ones against the above defects. With the support of nanotechnology, the solubility, absorption and targeting of traditional drugs were greatly improved by modifying and fabricating with various types of nanoparticles to some extent, though many shortages remain....
Source: International Journal of Medical Sciences - July 5, 2021 Category: Biomedical Science Authors: Jianhua Yang Chengyou Jia Jianshe Yang Source Type: research

Distinct Patterns of Brain Atrophy associated with Mild Behavioral Impairment in Cognitively Normal Elderly Adults
Int J Med Sci. 2021 Jun 11;18(13):2950-2956. doi: 10.7150/ijms.60810. eCollection 2021.ABSTRACTA cross-sectional study was conducted to evaluate patterns of gray matter changes in cognitively normal elderly adults with mild behavioral impairment (MBI). Sixteen MBI patients and 18 healthy controls were selected. All the participants underwent a neuropsychological assessment battery, including the Mini-mental State Examination (MMSE), Geriatric Depression Scale (GDS), Self-rating Anxiety Scale (SAS), and Chinese version of the mild behavioral impairment-checklist scale (MBI-C), and magnetic resonance imaging (MRI) scans. Ima...
Source: International Journal of Medical Sciences - July 5, 2021 Category: Biomedical Science Authors: Jun Shu Qiang Qiang Yuning Yan Yang Wen Yiqing Ren Wenshi Wei Li Zhang Source Type: research