Usefulness of four-limb blood pressure measurement in prediction of overall and cardiovascular mortality in acute myocardial infarction.
Authors: Hsu PC, Lee WH, Tsai WC, Chu CY, Lee CS, Yen HW, Lin TH, Voon WC, Lai WT, Sheu SH, Su HM Abstract Four-limb blood pressure measurement could improve mortality prediction in the elderly. However, there was no study to evaluate whether such measurement was still useful in predicting overall and cardiovascular (CV) mortality in acute myocardial infarction (AMI). Two hundred AMI patients admitted to cardiac care unit were enrolled. The 4-limb blood pressures, inter-limb blood pressure differences, and ankle brachial index (ABI) were measured using an ABI-form device. The median follow-up to mortality was 64 mo...
Source: International Journal of Medical Sciences - July 7, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

The Role of Histone Acetyltransferases and Histone Deacetylases in Photoreceptor Differentiation and Degeneration.
Authors: Zhao M, Tao Y, Peng GH Abstract Photoreceptors are critical components of the retina and play a role in the first step of the conversion of light to electrical signals. The differentiation and degeneration of photoreceptors are regulated by specific genes and proteins. With the development of epigenetic approaches, scientists have discovered that histone modifications, such as acetylation, methylation, ubiquitylation, and phosphorylation, may modulate the processes of photoreceptor differentiation and degeneration. Histone acetylation is regulated by two opposing classes of enzymes, namely, histone acetylt...
Source: International Journal of Medical Sciences - July 7, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Long non-coding RNA GAS5 expression in patients with Down syndrome.
Authors: Salemi M, Marchese G, Cordella A, Cannarella R, Barone C, Salluzzo MG, Calogero AE, Romano C Abstract Trisomy 21, also known as Down Syndrome (DS), is the most common chromosome abnormality and causes intellectual disability. Long non-coding RNA (lncRNA) growth arrest-specific 5 (GAS5), whose differential expression has recently been reported in patients with Klinefelter syndrome, has been addressed to play a role in the development of inflammatory and autoimmune diseases, vascular endothelial cells apoptosis and atherosclerosis, all being common features in patients with DS. Therefore, the aim of this stu...
Source: International Journal of Medical Sciences - July 7, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

The emerging role of EGFL6 in angiogenesis and tumor progression.
Authors: Kang J, Wang J, Tian J, Shi R, Jia H, Wang Y Abstract Epidermal growth factor-like domain-containing protein 6 (EGFL6) belongs to the epidermal growth factor (EGF) superfamily. EGFL6 is expressed at higher levels in embryos and various malignant tumors than in normal tissues. Recent studies suggest that EGFL6 participates in the development of a variety of tumors. In this review, we summarize findings that support the role for EGFL6 in tumor proliferation, invasion and migration. Furthermore, our review results indicate the mechanism of EGFL6 activity angiogenesis. We also describe work toward the preparat...
Source: International Journal of Medical Sciences - July 7, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

The Process of Osteoblastic Infection by Staphylococcus Aureus.
Authors: Wen Q, Gu F, Sui Z, Su Z, Yu T Abstract Bone infection is difficult to cure, and relapse frequently occurs, which is a major treatment problem. One of the main reasons for the refractory and recurrent nature of bone infection is that bacteria, such as Staphylococcus aureus (S. aureus), can be internalized into osteoblasts after infecting bone tissue, thereby avoiding attack by the immune system and antibiotics. Understanding how bacteria (such as S. aureus) are internalized into osteoblasts is key to effective treatment. S. aureus is the most common pathogenic bacterium that causes bone infection. This pap...
Source: International Journal of Medical Sciences - July 7, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Outcome in Patients Resuscitated following Myocardial Infarction with Acute Kidney Injury.
Authors: Kanic V, Ekart R, Kanic Z Abstract Background: Data on acute kidney injury (AKI) in patients with myocardial infarction (MI) who underwent percutaneous coronary intervention (PCI) after cardiac arrest are scarce. The prevalence of AKI, as classified by the Kidney Disease: Improving Global Outcomes (KDIGO) criteria; and its possible association with 30-day mortality were assessed. Methods: Data on 6387 patients with MI, 342 (5.3%) with out-of-hospital cardiac arrest or arrest immediately after admission before PCI, were retrospectively analyzed. The AKI and no-AKI groups were compared. The 30-day mortality ...
Source: International Journal of Medical Sciences - July 7, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Cardiovascular disease management during the coronavirus disease 2019 pandemic.
Authors: Lee WH, Chen YC, Chen SC, Chen CJ, Hsu PC, Tsai WC, Chu CY, Lee CS, Lin TH, Voon WC, Kuo CH, Su HM Abstract Based on clinical presentation, pathophysiology, high infectivity, high cardiovascular involvement, and therapeutic agents with cardiovascular toxicity of coronavirus disease 2019 (COVID-19), regular cardiovascular treatment is being changing greatly. Despite angiotensin-converting enzyme 2 serving as the portal for infection, the continuation of clinically indicated renin-angiotensin-aldosterone blockers is recommended according to the present evidence. Fibrinolytic therapy can be considered a reaso...
Source: International Journal of Medical Sciences - July 7, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Cirrhosis in Wilson Disease is characterized by Impaired Hepatic Synthesis, Leukopenia and Thrombocytopenia.
This study aimed to delineate hepatic features in WD patients with or without cirrhosis. Methods: Medical data were retrospectively collected from 27 July 2015 to 27 June 2018. WD patients were divided into two groups based on whether or not they progressed to cirrhosis. Liver function, portal hypertension features and hematocytopenia rates were compared between groups. Results: The study enrolled 119 WD patients with cirrhosis and 53 WD patients without cirrhosis. There were no differences between groups for liver enzyme levels or incidence rates of Kayser-Fleischer ring (all P> 0.05). Ascites and hepatic encephalopath...
Source: International Journal of Medical Sciences - July 7, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Circular RNA Expression Profiles and the Pro-tumorigenic Function of CircRNA_10156 in Hepatitis B Virus-Related Liver Cancer.
Authors: Wang M, Gu B, Yao G, Li P, Wang K Abstract Liver cancer is one of the most common malignant tumors in the world. Circular RNAs (circRNAs) perform important functions in cancer progression and are regarded as prospective biomarkers for cancer diagnosis and therapy. Here, we used the high-throughput RNA sequencing technology in conjunction with bioinformatics tools to profile circRNA expression in patients with HBV-related liver cancer. A total of 13,124 circRNAs were identified in HBV-related liver cancer, approximately 86.25% of which were sense-overlapping circRNAs. Moreover, 2,996 circRNAs exhibited diff...
Source: International Journal of Medical Sciences - July 7, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

The prediction value of PI-RADS v2 score in high-grade Prostate Cancer: a multicenter retrospective study.
Conclusions: PI-RADS v2 score had the value in predicting high-grade prostate cancer and the nomogram prediction model may help early diagnose the high risk prostate cancer. PMID: 32624693 [PubMed - in process] (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - July 7, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Cladribine Induces ATF4 Mediated Apoptosis and Synergizes with SAHA in Diffuse Large B-Cell Lymphoma Cells.
Authors: Xu L, Jiao J, Sun X, Sang W, Gao X, Yang P, Yan D, Song X, Sun C, Liu M, Qin Y, Tian Y, Zhu F, Zeng L, Li Z, Xu K Abstract Cladribine is a purine nucleoside analog used to treat B-cell chronic lymphocytic leukemia and hairy cell leukemia, also functions as an inhibitor of DNA synthesis to block the repair of the damaged DNA. The therapeutic role of cladribine against diffuse large B-cell lymphoma cells (DLBCL) is still undefined. In the present study, we demonstrated that cladribine inhibited cell proliferation and induced G1 phase arrest in human DLBCL cells. Furthermore, we showed that cladribine induced...
Source: International Journal of Medical Sciences - July 7, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Use of Intense Pulsed Light to Mitigate Meibomian Gland Dysfunction for Dry Eye Disease.
Authors: Suwal A, Hao JL, Zhou DD, Liu XF, Suwal R, Lu CW Abstract Dry Eye Disease (DED) is a common ocular condition that needs prompt diagnosis and careful treatment interventions. If left untreated, it can lead to numerous sight-threatening complications, including ulceration of the cornea, blepharitis, alterations of the tear film, conjunctivitis, and in severe cases, may lead to scarring, thinning, and even perforation of the cornea. Intense pulsed light (IPL) is a non-laser high-intensity light source that has shown to play a valuable role in dry eye disease. Recent evidence from various research works has sh...
Source: International Journal of Medical Sciences - July 7, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Development and validation of a novel immune-related prognostic model in lung squamous cell carcinoma.
Conclusions: We constructed a risk model using four PDIRGs that can accurately predict the prognosis of LUSC patients. The risk score generated by this model can be used as an independent prognostic indicator. Moreover, the model can predict the infiltration of immune cells in patients, which is conducive to the prediction of patient sensitivity to immunotherapy. PMID: 32624696 [PubMed - in process] (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - July 7, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

EGFRvIII-specific CAR-T cells produced by piggyBac transposon exhibit efficient growth suppression against hepatocellular carcinoma.
In conclusion, EGFRvIII CAR-T cells demonstrated specific antitumor effect against SMMC7721 in vitro and in vivo, providing basis for immunotherapy of HCC in future clinical use. PMID: 32624697 [PubMed - in process] (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - July 7, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Inhibition of miR-25 attenuates doxorubicin-induced apoptosis, reactive oxygen species production and DNA damage by targeting PTEN.
Conclusion: In conclusion, this study demonstrated that miR-25 is involved in DOX-induced cell damage through the regulation of PTEN expression. PMID: 32624698 [PubMed - in process] (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - July 7, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Tumor-derived circulating exosomal miR-342-5p and miR-574-5p as promising diagnostic biomarkers for early-stage Lung Adenocarcinoma.
Authors: Han Z, Li Y, Zhang J, Guo C, Li Q, Zhang X, Lan Y, Gu W, Xing Z, Liang L, Li M, Mi S Abstract Lung cancer has been the leading cause of cancer morbidity and mortality in recent years. Most lung cancers are often asymptomatic until advanced or metastatic stage. Therefore, looking for the diagnostic biomarker for early-stage lung cancer is quite significant. Circulating exosomal microRNAs (miRNAs) have been reported to be the diagnostic and prognostic markers of various cancers. Here, we obtained circulating exosomal miRNA repertoires of 7 early-stage lung adenocarcinoma patients including pre-operation and ...
Source: International Journal of Medical Sciences - July 7, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Efficient GAN-based Chest Radiographs (CXR) augmentation to diagnose coronavirus disease pneumonia.
Conclusion: If the gap in identifying of all viral pneumonias is not filled with effective automation of chest disease detection the healthcare industry may have to bear unfavorable circumstances. PMID: 32624700 [PubMed - in process] (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - July 7, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Pretreatment biomarkers as prognostic predictors of survival in patients with Pancreatic Cancer treated with Gemcitabine-based Therapy and 5-Fluorouracil: Neutrophil-to-lymphocyte ratio vs Platelet-to-lymphocyte ratio.
In conclusion, pretreatment NLR is a promising independent outcome predictor for patients with PC, while NLR might not be a suitable factor in the selection of regimens for patients with PC. PMID: 32624701 [PubMed - in process] (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - July 7, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

The efficacy of addition of Tenofovir Disoproxil Fumarate to Peg-IFN α-2b is superior to the addition of Entecavir in HBeAg positive CHB patients with a poor response after 12 weeks of Peg-IFNα-2b treatment alone.
In this study, we aimed to evaluate the efficacy of ETV and TDF in HBeAg positive CHB patients who had a poor response to Peg-INFα-2b at the end of 12 weeks of monotherapy. Methods: A total of 40 HBeAg-positive CHB patients who were naive to antiviral therapy were recruited. The patients received a subcutaneous injection of Peg-IFNα-2b (180 µg) once a week for 12 weeks. However, the patients had a poor response to Peg-INFα-2b at the end of the 12-week-period monotherapy. The patients were then divided into two therapeutic protocol groups: (1) Group A: Patients received Peg-IFNα-2b (180 µ...
Source: International Journal of Medical Sciences - July 7, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Berberine Inhibits Pro-inflammatory Cytokine-induced IL-6 and CCL11 Production via Modulation of STAT6 Pathway in Human Bronchial Epithelial Cells.
In this study, we evaluated the anti-inflammatory efficacy of berberine on allergic airway inflammation by targeting epithelial cells. Allergic airway inflammation driven by T helper 2 (Th2)-type immunity is characterized by airway hyperresponsiveness, elevated IgE production, and eosinophilic infiltration. For eosinophil recruitment, major chemoattractant CCL11 (eotaxin-1) was secreted by lung epithelial cells. BEAS-2B cells, a human bronchial epithelial cell line, were pre-treated with berberine and then activated by IL-4 plus TNF-α. The viability of BEAS-2B cells was assessed. Expression levels of IL-6 and CCL11 w...
Source: International Journal of Medical Sciences - July 7, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Possible misdiagnosis of 46,XX testicular disorders of sex development in infertile males.
Conclusions: Chromosomal analysis rarely yields 46,XX karyotype combined with no deletion of AZF in infertile males. Under this condition, molecular analysis should be conducted to avoid potential misdiagnosis and false interpretation of other findings. PMID: 32547308 [PubMed - in process] (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - June 18, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Characteristics of in peripheral blood of 70 hospitalized patients and 8 diarrhea patients with COVID-19.
Conclusion: Our data recommended that the ESR, CRP, PT, IL6, lymphocyte count, GGT, prealbumin and CD4 have important value in the diagnosis of COVID-19, and the decrease of GGT may be an important indicator for judging the intestinal dysfunction of patients. PMID: 32547309 [PubMed - in process] (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - June 18, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

N-acetylcysteine Restored Heart Rate Variability and Prevented Serious Adverse Events in Transfusion-dependent Thalassemia Patients: a Double-blind Single Center Randomized Controlled Trial.
This study was double-blind, randomized control trial, investigating in 59 Thai TDT patients. After randomization, the participants were divided into two groups. The control group received standard care of TDT patient plus placebo, whereas the intervention group received 600 mg of NAC orally for six months. Serum 8-isoprostane, TNF-alpha, IL-10, 24-hour ECG monitoring, echocardiograms and the incidence of thalassemia-related complications were collected. At baseline, no significant difference in any parameters between the control and the intervention groups. At the end of intervention, the incidence of serious adverse even...
Source: International Journal of Medical Sciences - June 18, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Baicalein Neutralizes Hypercholesterolemia-Induced Aggravation of Oxidative Injury in Rats.
Authors: AlSaad AM, Mohany M, Almalki MS, Almutham I, Alahmari AA, AlSulaiman M, Al-Rejaie SS Abstract Hypercholesterolemia is a major risk factor for several cardiovascular and metabolic diseases as it triggers oxidative and pro-inflammatory cascades. Baicalein (BL) is a natural flavone with multiple therapeutic properties. The present study aimed to evaluate the potential protective effect of BL supplementation in hypercholesterolaemic rats. Rats were fed a high-cholesterol diet (HCD) for six weeks and then orally administered BL at two doses (25 and 50 mg/kg body weight/day) for four weeks. Serum lipids, liver e...
Source: International Journal of Medical Sciences - June 18, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Persistent oppression and simple decompression both exacerbate spinal cord ascorbate levels.
Conclusion: Our study provides first-hand direct experimental evidence indicating ascorbate is directly involved in secondary spinal cord injury and exhibits the dynamic time course of microenvironment changes after continuous compression injury of the spinal cord. PMID: 32547312 [PubMed - in process] (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - June 18, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Circ-APBB1IP as a Prognostic Biomarker Promotes Clear Cell Renal Cell Carcinoma Progression Through The ERK1/2 Signaling Pathway.
This study aims to investigate the effect and mechanisms of circRNA on ccRCC progression. A human circRNA microarray was used to discover differential expression circRNA, and a quantitative real-time polymerase chain reaction (qRT-PCR) was performed to verify the expression of circRNA. The function and mechanism of circRNA were explored by cell transfection, cell counting kit-8, fluorescein isothiocyanate (FITC) Annexin V apoptosis detection, wound healing, transwell, and western blot. The result indicated that circ-APBB1IP was significantly up-regulated in ccRCC. In vitro, knockdown of circ-APBB1IP by siRNA suppressed the...
Source: International Journal of Medical Sciences - June 18, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

The relationships of genetic polymorphisms of the long noncoding RNA growth arrest-specific transcript 5 with uterine cervical cancer.
Authors: Weng SL, Ng SC, Lee YC, Hsiao YH, Hsu CF, Yang SF, Wang PH Abstract The purposes of the investigation were to examine the implications of long noncoding RNA growth arrest-specific transcript 5 (GAS5) in progression and clinicopathological factors of uterine cervical cancer, and patient survival in Taiwan. Genotypic distributions of two GAS5 genetic variants rs145204276 and rs55829688 were detected in 208 patients including 111 patients with invasive cancer, 97 with precancerous lesions as well as 307 control women using real-time polymerase chain reaction. It explored that patients with cervical precancero...
Source: International Journal of Medical Sciences - June 18, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Downregulation of P300/CBP-Associated Factor Attenuates Myocardial Ischemia-Reperfusion Injury Via Inhibiting Autophagy.
This study was to investigate whether downregulation of PCAF attenuate MIRI. The results showed that the expression of PCAF was significantly increased in MIRI in vivo and in vitro. Downregulation of PCAF not only inhibited autophagy and damage of H9c2 cells induced by hypoxia-reoxygenation, but also reduced autophagy and myocardial infarct size during myocardial ischemia-reperfusion in rats. In addition, downregulation of PCAF promoted activation of PI3K/Akt/mTOR signaling pathway in cardiomyocytes during hypoxia-reoxygenation. Wortmannin, a PI3K/Akt inhibitor, could abrogate the effects of downregulation of PCAF on cardi...
Source: International Journal of Medical Sciences - June 18, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

S1P promotes IL-6 expression in osteoblasts through the PI3K, MEK/ERK and NF- κB signaling pathways.
S1P promotes IL-6 expression in osteoblasts through the PI3K, MEK/ERK and NF-κB signaling pathways. Int J Med Sci. 2020;17(9):1207-1214 Authors: Hu SL, Huang CC, Tzeng TT, Liu SC, Tsai CH, Fong YC, Tang CH Abstract Rheumatoid arthritis (RA) is a systemic autoimmune inflammatory disease, in which the immune system attacks joint tissue. Interleukin (IL)-6 is a key proinflammatory cytokine in RA progression. Sphingosine-1-phosphate (S1P), a platelet-derived lysophospholipid mediator, reportedly regulates osteoimmunology. Here, we examined the effects of S1P on IL-6 expression in osteoblasts. Our res...
Source: International Journal of Medical Sciences - June 18, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Notch1 Affects Chemo-resistance Through Regulating Epithelial-Mesenchymal Transition (EMT) in Epithelial Ovarian cancer cells.
Conclusion: Notch1 affects EOC cells chemo-resistance by regulating EMT. This may provide a new target for the treatment of ovarian cancer. PMID: 32547317 [PubMed - in process] (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - June 18, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Long non-coding RNA LINC01503 promotes the progression of hepatocellular carcinoma via activating MAPK/ERK pathway.
Conclusion: LINC01503 is highly expressed in HCC and promotes the progression of HCC via MAPK/ERK pathway, which maybe a new potential biomarker and therapeutic target for HCC. PMID: 32547318 [PubMed - in process] (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - June 18, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Melatonin Protects Human Renal Proximal Tubule Epithelial Cells Against High Glucose-Mediated Fibrosis via the Cellular Prion Protein-TGF- β-Smad Signaling Axis.
Melatonin Protects Human Renal Proximal Tubule Epithelial Cells Against High Glucose-Mediated Fibrosis via the Cellular Prion Protein-TGF-β-Smad Signaling Axis. Int J Med Sci. 2020;17(9):1235-1245 Authors: Han YS, Yoon YM, Go G, Lee JH, Lee SH Abstract Diabetes-mediated hyperglycemia is a major risk factor for renal fibrosis, resulting in the development of chronic kidney diseases. To address this issue, the effect of melatonin, which has an antioxidative potential, on renal fibrosis in human renal proximal tubule epithelial cells under high glucose conditions was investigated. Under high glucose ...
Source: International Journal of Medical Sciences - June 18, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

AKR1B10 Inhibitor Epalrestat Facilitates Sorafenib-Induced Apoptosis and Autophagy Via Targeting the mTOR Pathway in Hepatocellular Carcinoma.
In conclusion, epalrestat heightens sorafenib's anti-cancer effects via blocking the mTOR pathway, thus inducing cell cycle arrest, apoptosis, and autophagy. PMID: 32547320 [PubMed - in process] (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - June 18, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

IL-1 β Promotes Stemness of Tumor Cells by Activating Smad/ID1 Signaling Pathway.
Conclusion: Our data demonstrates that IL-1β promotes the stemness of HNSCC and melanoma cells through activating Smad/ID1 signal pathway. PMID: 32547321 [PubMed - in process] (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - June 18, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Identification of the key genes and microRNAs in adult acute myeloid leukemia with FLT3 mutation by bioinformatics analysis.
Conclusion: Our study successfully identified molecular markers, processes and pathways affected by FLT3 mutation in AML. Furthermore, miR-10a-3p, a novel oncogene, might involve in the development of FLT3 mutation adult AML by targeting SLC14A1, ARHGAP5 and PIK3CA. PMID: 32547322 [PubMed - in process] (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - June 18, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Factors associated with death outcome in patients with severe coronavirus disease-19 (COVID-19): a case-control study.
This study aims to explore the feasible parameters which could be used in clinical practice to predict the prognosis in hospitalized patients with severe coronavirus disease-19 (COVID-19). Methods: In this case-control study, patients with severe COVID-19 in this newly established isolation center on admission between 27 January 2020 to 19 March 2020 were divided to discharge group and death event group. Clinical information was collected and analyzed for the following objectives: 1. Comparisons of basic characteristics between two groups; 2. Risk factors for death on admission using logistic regression; 3. Dynamic changes...
Source: International Journal of Medical Sciences - June 18, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Mitochondrial Transcription Factor A added to Osteocytes in a Stressed Environment has a Cytoprotective Effect.
Authors: Ueda S, Shimasaki M, Ichiseki T, Hirata H, Kawahara N, Ueda Y Abstract The main precipitant of glucocorticoid-associated femoral head osteonecrosis is widely accepted to be an ischemic-hypoxic event, with oxidative stress also as an underlying factor. Mitochondrial DNA is more vulnerable to oxidative injury than the nucleus, and mitochondrial transcription factor A (TFAM), which plays roles in its function, preservation, and regulation is being increasingly investigated. In the present study we focused on the impact of TFAM on the relation between the oxidative injury induced by the addition of glucocortic...
Source: International Journal of Medical Sciences - June 18, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

The Effect of Intracoronary Infusion of Autologous Bone Marrow-Derived Lineage-Negative Stem/Progenitor Cells on Remodeling of Post-Infarcted Heart in Patient with Acute Myocardial Infarction.
Conclusions: Intracoronary infusion of autologous BM-derived LIN- stem/progenitor cells is feasible and safe for patient. Improvement in LV function and prevention of unfavorable remodeling in the 60% of study group seems relatively promising. Stem cell-based therapy for cardiac regeneration still needs more accurate and extensive investigations to estimate and improve their efficacy. PMID: 32410827 [PubMed - in process] (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - May 17, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Inhibitor of Differentiation 1 (Id1) in Cancer and Cancer Therapy.
Authors: Zhao Z, Bo Z, Gong W, Guo Y Abstract The inhibitor of DNA binding (Id) proteins are regulators of cell cycle and cell differentiation. Of all Id family proteins, Id1 is mostly linked to tumorigenesis, cellular senescence as well as cell proliferation and survival. Id1 is a stem cell-like gene more than a classical oncogene. Id1 is overexpressed in numerous types of cancers and exerts its promotion effect to these tumors through different pathways. Briefly, Id1 was found significantly correlated with EMT-related proteins, K-Ras signaling, EGFR signaling, BMP signaling, PI3K/Akt signaling, WNT and SHH signal...
Source: International Journal of Medical Sciences - May 17, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Tendril extract of Cucurbita moschata suppresses NLRP3 inflammasome activation in murine macrophages and human trophoblast cells.
In this study, we investigated the effects of hot water extract derived from the tendrils of C. moschata Duchesne (TCMD) on NLRP3 inflammasome activation in murine macrophages and human trophoblast cells. The TCMD treatment of LPS-primed bone marrow-derived macrophages (BMDMs) and human trophoblast cells attenuated NLRP3 inflammasome activation induced by inflammasome activators such as ATP, nigericin, and monosodium urate (MSU). TCMD treatment suppressed IL-1β secretion in a dose-dependent manner, without affecting IL-6 secretion. In addition, TCMD inhibited NLRP3-dependent pyroptosis in BMDMs. TCMD also suppressed t...
Source: International Journal of Medical Sciences - May 17, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Anti-cancer therapeutic benefit of red guava extracts as a potential therapy in combination with doxorubicin or targeted therapy for triple-negative breast cancer cells.
In this study, cell viability was determined by using the MTT assay. Apoptosis and necrosis were analyzed using flow cytometry. Cleaved caspase-3 and PARP were analyzed by western blotting. We found that red guava extracts can, through caspase-3 activation and PARP cleavage signaling, induce apoptotic and necrotic death in TNBC cells. Our results thus show the therapeutic benefit of red guava extracts as a potential cancer treatment for TNBC in combination with doxorubicin or targeted therapy. PMID: 32410830 [PubMed - in process] (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - May 17, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Incidence and Risk Factors of Acute Kidney Injury after Kasai Operation for Biliary Atresia: A Retrospective Study.
Conclusions: Increased age is strongly associated with the development of AKI after Kasai operation. These findings indicate a rational basis for early corrective surgery for biliary atresia, early screening for AKI, and intervention to improve the results of Kasai operation. PMID: 32410831 [PubMed - in process] (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - May 17, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Fibroblast Proliferation and Migration in Wound Healing by Phytochemicals: Evidence for a Novel Synergic Outcome.
Authors: Addis R, Cruciani S, Santaniello S, Bellu E, Sarais G, Ventura C, Maioli M, Pintore G Abstract Wound-healing is a dynamic skin reparative process that results in a sequence of events, including inflammation, proliferation, and migration of different cell types as fibroblasts. Fibroblasts play a crucial role in repairing processes, from the late inflammatory phase until the fully final epithelization of the injured tissue. Within this context, identifying tools able to implement cell proliferation and migration could improve tissue regeneration. Recently, plants species from all over the world are coming ou...
Source: International Journal of Medical Sciences - May 17, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

A novel method of bilateral patent processus vaginalis ligation in transumbilical single-site multiport laparoscopic orchiopexy.
Conclusion: The novel ligation was safety and efficacy. It is relatively easy to perform with smaller scar and less pain. We propose the novel ligation as a more viable treatment option for pediatric cryptorchidism with bilateral patent processus vaginalis. PMID: 32410833 [PubMed - in process] (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - May 17, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Ginsenoside Rg1 ameliorates the cognitive deficits in D-galactose and AlCl3-induced aging mice by restoring FGF2-Akt and BDNF-TrkB signaling axis to inhibit apoptosis.
In this study, chemically induced aging mice were established by consecutive administration of D-galactose and AlCl3. We found that Rg1 effectively ameliorates spatial learning and memory deficits in aging mice demonstrated by their improved performance in step down avoidance tests and Morris water maze experiments. Rg1 restored aging-induced decline of FGF2 and BDNF, reactivated TrkB/Akt signaling pathways in the hippocampus and prefrontal cortex to inhibit apoptosis, for the expression of anti-apoptotic protein Bcl-2 and apoptosis promoting enzyme cleaved-Caspase3 were antagonistically restored. Therefore, these results ...
Source: International Journal of Medical Sciences - May 17, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Interleukin-1 β Promotes Ox-LDL Uptake by Human Glomerular Mesangial Cells via LOX-1.
Interleukin-1β Promotes Ox-LDL Uptake by Human Glomerular Mesangial Cells via LOX-1. Int J Med Sci. 2020;17(8):1056-1061 Authors: Liu H, Li Y, Lin N, Dong X, Li W, Deng Y, Ma L Abstract The aim of this study was to determine whether interleukin-1β (IL-1β) promotes oxidised low-density lipoprotein (Ox-LDL) uptake by human glomerular mesangial cells (HMCs) and its effect on the expression of lectin-like Ox-LDL receptor 1 (LOX-1) and to identify pathways through which IL-1β affects lipid uptake. Confocal laser scanning microscopy and flow cytometry were used to observe the effect of IL...
Source: International Journal of Medical Sciences - May 17, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Cross-talk between MYOC p. Y437H mutation and TGF- β2 in the pathology of glaucoma.
Conclusion: These data collectively suggest that the mutual interaction between glaucomatous MYOC mutation and TGF-β2 contributed to the cell death of TM cells. This relationship also provides a new, therapeutic targets for the treatment of glaucoma. PMID: 32410836 [PubMed - in process] (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - May 17, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Myocardial Ischemic Syndromes, Heart Failure Syndromes, Electrocardiographic Abnormalities, Arrhythmic Syndromes and Angiographic Diagnosis of Coronary Artery Spasm: Literature Review.
Authors: Hung MY, Kounis NG, Lu MY, Hu P Abstract In coronary artery spasm (CAS), an excess coronary vasoconstriction causing total or subtotal vessel occlusion could lead to syncope, heart failure syndromes, arrhythmic syndromes, and myocardial ischemic syndromes including asymptomatic myocardial ischemia, stable and unstable angina, acute myocardial infarction, and sudden cardiac death. Although the clinical significance of CAS has been underrated because of the frequent absence of symptoms, affected patients appear to be at higher risk of syncope, serious arrhythmias, and sudden death than those with classic Heb...
Source: International Journal of Medical Sciences - May 17, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Improved tendon healing by a combination of Tanshinone IIA and miR-29b inhibitor treatment through preventing tendon adhesion and enhancing tendon strength.
Conclusion: We conclude that the use of miR-29b inhibitor at the end of the tendon break could initiate endogenous repair mechanism and subsequently use of TSA should be able to inhibit the exogenous repair mechanism. Therefore, the combination of both treatments could prevent tendon adhesion and ensure tendon strength. Our findings suggested that this approach would be a feasible approach for tendon repair. PMID: 32410838 [PubMed - in process] (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - May 17, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

The Role of Cyclooxygenase-2 in Colorectal Cancer.
Authors: Sheng J, Sun H, Yu FB, Li B, Zhang Y, Zhu YT Abstract Colorectal cancer is the third common cancer in this world, accounting for more than 1 million cases each year. However, detailed etiology and mechanism of colorectal cancer have not been fully understood. For example, cyclooxygenase-2 (COX-2) and its product prostaglandin E2 (PGE2) have been closely linked to its occurrence, progression and prognosis. However, the mechanisms on how COX-2 and PGE2-mediate the pathogenesis of colorectal cancer are obscure. In this review, we have summarized recent advances in studies of pathogenesis and control in colore...
Source: International Journal of Medical Sciences - May 17, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research