Identification of Key Genes and Pathways in Myeloma side population cells by Bioinformatics Analysis.
Conclusions: In conclusion, this study provides reliable molecular biomarkers for screening, prognosis, as well as novel therapeutic targets for myeloma LC/SP cells. PMID: 32922167 [PubMed - in process] (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - September 16, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Comprehensive Transcriptome Profiling of Peripheral Blood Mononuclear Cells from Patients with Sepsis.
In this study, we investigated this syndrome by analyzing the transcriptome of peripheral blood mononuclear cells (PBMCs) from patients with sepsis and identified sepsis-specific biomarkers. Methods: In this study, a total of 87 patients with sepsis and 40 healthy controls from a prospective multicenter cohort were enrolled. Samples from 44 subjects (24 patients with sepsis and 20 healthy controls) were sequenced and the remaining patients were included in the validation group. Using high-throughput sequencing, a gene expression profile of PBMCs from patients with sepsis was generated to elucidate the pathophysiology of se...
Source: International Journal of Medical Sciences - September 16, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Rapamycin blocks the IL-13-induced deficiency of Epidermal Barrier Related Proteins via upregulation of miR-143 in HaCaT Keratinocytes.
This study proposed that IL-13 could activate the mTOR signaling pathway, and confirmed the vital role of mTOR-miR-143 signaling axis in the pathogenesis of AD. It provided solid evidences regarding rapamycin as a potential effective therapeutic option in the management of AD. PMID: 32922169 [PubMed - in process] (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - September 16, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Tert-butylhydroquinone mitigates Carbon Tetrachloride induced Hepatic Injury in mice.
In conclusion, our study revealed tBHQ can be a potential therapeutic drug in treatment of acute hepatic injury. PMID: 32922170 [PubMed - in process] (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - September 16, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Platelet lysates in Hepatocellular Carcinoma patients after radiofrequency ablation facilitate tumor proliferation, invasion and vasculogenic mimicry.
Conclusions: Platelet lysates from HCC patients after RFA promoted the proliferation, migration, invasion and vasculogenic mimicry of HCC cells, which indicated that RFA in combination with anti-platelet drug may be used to improve the prognosis of HCC. PMID: 32922171 [PubMed - in process] (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - September 16, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Serum transferrin predicts end-stage Renal Disease in Type 2 Diabetes Mellitus patients.
Authors: Zhao L, Zou Y, Zhang J, Zhang R, Ren H, Li L, Guo R, Zhang J, Liu F Abstract Background: To investigate the relationship between serum iron status and renal outcome in patients with type 2 diabetes mellitus (T2DM). Methods: Chinese patients (n=111) with T2DM and biopsy-proven diabetic nephropathy (DN) were surveyed in a longitudinal, retrospective study. Serum iron, total iron-binding capacity, ferritin, and transferrin were measured at the time of renal biopsy. Iron deposition and transferrin staining were performed with renal biopsy specimens of DN patients and potential kidney donors. End-stage renal di...
Source: International Journal of Medical Sciences - September 16, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Fangcang Shelter Hospital in Wuhan: A radiographic report on a cohort of 98 COVID-19 patients.
Conclusion: Discharged patients from fangcang shelter hospital demonstrated a high extent of lung abnormalities on CT within the first week from symptom onset, peaked at 2nd week, followed by persistence of high levels and a prolonged median disease course. GGO was the predominant pattern in week 1, consolidation and mixed pattern in 2nd week, whereas GGO and reticular patterns in later stages (≥4 weeks). PMID: 32922173 [PubMed - in process] (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - September 16, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

COVID-19: Rational discovery of the therapeutic potential of Melatonin as a SARS-CoV-2 main Protease Inhibitor.
Authors: Feitosa EL, Júnior FTDSS, Nery Neto JAO, Matos LFL, Moura MHS, Rosales TO, De Freitas GBL Abstract The SARS-CoV-2 spread quickly across the globe. The World Health Organization (WHO) on March 11 declared COVID-19 a pandemic. The mortality rate, hospital disorders and incalculable economic and social damages, besides the unproven efficacy of the treatments evaluated against COVID-19, raised the need for immediate control of this disease. Therefore, the current study employed in silico tools to rationally identify new possible SARS-CoV-2 main protease (Mpro) inhibitors. That is an enzyme conserved amo...
Source: International Journal of Medical Sciences - September 16, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Stellate Ganglion Blockade repairs Intestinal Mucosal Barrier through suppression of Endoplasmic Reticulum Stress following Hemorrhagic Shock.
Conclusion: The SGB repairs intestinal mucosal barrier through suppression of ERS following hemorrhagic shock. PMID: 32922175 [PubMed - in process] (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - September 16, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Comparison of outcomes in intrauterine insemination, in vitro fertilisation and intracytoplasmic sperm injection in men with and without varicocele.
Conclusions: The increasing grade of varicocele was negatively associated with sperm parameters and can alter the outcome of further IUI/IVF. PMID: 32922176 [PubMed - in process] (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - September 16, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Therapeutic effects and mechanisms of actions of Descurainia sophia.
Authors: Hsieh PC, Kuo CY, Lee YH, Wu YK, Yang MC, Tzeng IS, Lan CC Abstract Descurainia sophia Webb ex Prantl has been used in traditional medicine globally. It has been shown that Descurainia sophia, together with many other bioactive compounds, can modulate the biological functions of various genes. We have viewed the clinical benefits and mechanisms of action of Descurainia sophia associated with its current uses and outlined potential further applications. There are many studies documenting its numerous clinical effects in cancer, respiratory, gastrointestinal, and cardiac systems. Further, Descurainia sophia ...
Source: International Journal of Medical Sciences - September 16, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Lower HDL-C levels are associated with higher expressions of CD16 on monocyte subsets in coronary atherosclerosis.
Conclusion: Low serum HDL-C may induce upregulation of CD16 on classical monocytes, which may in turn lead to the increase of intermediate monocytes in coronary atherosclerosis patients. PMID: 32922178 [PubMed - in process] (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - September 16, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Shorter Leukocyte Telomere Length coupled with lower expression of Telomerase Genes in patients with Essential Hypertension.
Authors: Cheng G, Wang L, Dai M, Wei F, Xu D Abstract Background: The essential hypertension (EH) pathophysiology remains poorly understood. Many studies indicate that reduced leukocyte telomere length (LTL) is involved in the EH pathogenesis, however, the direct analysis of arterial telomere length (ATL) from EH patients and normotensive individuals did not show a difference. To address these discrepant observations between LTL and ATL, we performed comprehensive analyses of LTL, telomerase gene expression and their genetic variants in healthy normotensive controls and EH patients. Methods: Sex-matched 206 EH pati...
Source: International Journal of Medical Sciences - September 16, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Determination of risk factors for predicting the onset of symptoms in asymptomatic COVID-19 infected patients.
Conclusion: The initially asymptomatic patients can develop mild symptoms and have a good prognosis. History of smoking and pulmonary disease was prone to illness onset in asymptomatic patients, and it is necessary to be highly vigilant to those patients. PMID: 32922180 [PubMed - in process] (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - September 16, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Sedation and Analgesia for Liver Cancer Percutaneous Radiofrequency Ablation: Fentanyl and Oxycodone Comparison.
Conclusions: Both oxycodone and fentanyl can be applied for liver cancer percutaneous radiofrequency ablation; however, oxycodone provides a better patient experience, lower postoperative pain, less respiratory depression and stable haemodynamic fluctuations. PMID: 32922181 [PubMed - in process] (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - September 16, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Fine Particulate Matter (PM2.5) upregulates expression of Inflammasome NLRP1 via ROS/NF- κB signaling in HaCaT Cells.
This study aims to investigate the effect of PM2.5 on the formation of inflammasomes in skin cells and to explore the potential mechanism linking PM2.5 and skin inflammation. Changes in mRNA and protein levels of inflammasome-related genes were detected by real-time PCR and western blot in human immortalized epidermal cells (HaCaT) treated with PM2.5 at multiple concentrations for 24 hours. The expression of NLRP1 was increased significantly both in mRNA and protein levels after PM2.5 exposure while the elevated secretory protein level of IL-1β in cell culture was detected by ELISA, which is one of the main downstream...
Source: International Journal of Medical Sciences - September 16, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

2,3,5,4'-tetrahydoxystilbene-2-O- β-D-glucoside eliminates staurosporine-induced cytotoxicity by restoring BDNF-TrkB/Akt signaling axis.
In this study, hippocampal neurons were challenged with staurosporine (STS) to establish a neural damage model. We found that STS-induced cytotoxicity introduced significant morphological collapse and initiating cell apoptosis, along with the down regulation of BDNF and TrkB/Akt signaling axis. In contrast, neurons pretreated with THSG showed resistance to STS-induced toxicity and maintained cell survival. THSG rescued STS induced dysfunctions of BDNF and its associated TrkB/Akt signaling, and restored the expression of Bcl-2 and Caspase-3. However, inhibition of TrkB activity by K252a or Akt signaling by LY294002 abolishe...
Source: International Journal of Medical Sciences - September 16, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

NAD(P)H:quinone oxidoreductase 1 determines radiosensitivity of triple negative breast cancer cells and is controlled by long non-coding RNA NEAT1.
In conclusion, the NQO1 expression in triple-negative breast cancer cells determined their radiosensitivity and was controlled by NEAT1. In addition, NOQ1 bioactivatable compounds displayed potential for application in the development of radiation sensitizers in breast cancer. PMID: 32922184 [PubMed - in process] (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - September 16, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Prognostic value of lactate dehydrogenase for in-hospital mortality in severe and critically ill patients with COVID-19.
In this study, we aimed to evaluate the association of LDH with in-hospital mortality in severe and critically ill patients with COVID-19. Methods: This single-center retrospective study enrolled 119 patients. Survival curves were plotted using Kaplan-Meier method and compared by log-rank test. Multivariate Cox regression models were used to determine the independent risk factors for in-hospital mortality. Receiver-operator curves (ROCs) were constructed to evaluate the predictive accuracy of LDH and other prognostic biomarkers. Results: Compared to the survival group, LDH levels in the dead group were significantly higher...
Source: International Journal of Medical Sciences - September 16, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

The Significance of iron deficiency and anemia in a real-life COPD cohort.
Conclusion: ID is common in COPD patients, but a uniform definition for accurate diagnosis does not exist. Prevalence of functional ID and anemia increased during follow-up. The associations of ID and anemia with reduced functional lung capacity and elevated inflammation may reflect a more severe COPD phenotype. PMID: 32922186 [PubMed - in process] (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - September 16, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Research on the potential mechanism of Chuanxiong Rhizoma on treating Diabetic Nephropathy based on network pharmacology.
Conclusions: Chuanxiong Rhizoma might take part in the treatment of DN through pathways associated with steroid hormone, estrogen, thyroid hormone and IL-17. KCNH2, NCOA1, KDR, ADRB2 and NR3C2 were proved to be the hub targets, which were closely related to corresponding active ingredients of Chuanxiong Rhizoma. PMID: 32922187 [PubMed - in process] (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - September 16, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Lnc-MAP6-1:3 knockdown inhibits osteosarcoma progression by modulating Bax/Bcl-2 and Wnt/ β-catenin pathways.
In this study, numerous dysregulated lncRNAs were identified by RNA-seq. As a result, we were able to find a novel lncRNA Lnc-MAP6-1:3 which is highly expressed in osteosarcoma. Using a set of approaches including gene knockdown, RT-PCR, oncogenic function assay and western blotting, we observed that knockdown of Lnc-MAP6-1:3 expression suppressed cell proliferation and colony formation, and promoted apoptosis in vitro. For the first time, we have identified that Lnc-MAP6-1:3 potentially influence the malignant behavior of osteosarcoma via Bax/Bcl-2 and Wnt/β-catenin signaling pathways. Henceforth, Lnc-MAP6-1:3 may pr...
Source: International Journal of Medical Sciences - September 16, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Prognosis models for severe and critical COVID-19 based on the Charlson and Elixhauser comorbidity indices.
Conclusions: This study established prognostic scoring models based on comorbidities and clinical information, which may help with the graded management of patients according to prognosis score and remind physicians to pay more attention to patients with high scores. PMID: 32922189 [PubMed - in process] (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - September 16, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

QRS-T-angle in Patients with ST-Segment Elevation Myocardial Infarction (STEMI) - a Comparison with Cardiac Magnetic Resonance Imaging.
Authors: Zadeh B, Wambach JM, Lambers M, Nassenstein K, Jensen CJ, Bruder O Abstract Background: The QRS-T angle from the surface EKG is a promising prognostic marker in patients with coronary artery disease. Cardiovascular magnetic resonance (CMR) imaging with late gadolinium enhancement (LGE) offers high resolution imaging of myocardial damage. We investigated the association of the QRS-T angle and the extent of myocardial damage as assessed by LGE in patients with acute ST-segment myocardial infarction (STEMI) Methods: 169 patients with STEMI obtained a standardized digital 12-lead EKG on admission for the calcu...
Source: International Journal of Medical Sciences - September 16, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Pictorial Imaging-Histopathology Correlation in a Rabbit with Hepatic VX2 Tumor Treated by Transarterial Vascular Disrupting Agent Administration.
Authors: He J, Liu C, Li T, Liu Y, Wang S, Zhang J, Chen L, Wang C, Feng Y, Floris G, Wang Z, Zhang X, Zhao L, Li Y, Shao H, Ni Y Abstract Cancer vasculature is immature, disorganized and hyperpermeable and can serve as a target for anti-cancer therapies. Vascular disrupting agents (VDAs) are tubulin protein binding and depolymerizing agents that induce rapid tumoral vascular shutdown and subsequent cancer necrosis. However, two clinical problems exist with all VDAs, i.e. 1) incomplete anticancer effect and 2) dose-dependent toxicity. To tackle these problems, in our ongoing research, a novel VDA C118P is applied b...
Source: International Journal of Medical Sciences - September 16, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Postoperative BMI Loss at One Year Correlated with Poor Outcomes in Chinese Gastric Cancer Patients.
Authors: Wang N, Jiang J, Xi W, Wu J, Zhou C, Shi M, Wang C, Zhu Z, Liu J, Zhang J Abstract Purpose: The present study focused on the long-term prognostic value of dynamic body mass index (BMI) change in gastric cancer patients who underwent gastrectomy. Methods: Clinical data from a total of 576 gastric cancer patients who underwent radical gastrectomy were collected. Univariate and multivariate analyses were performed to demonstrate the association between dynamic BMI variables (BMI before surgery, 1 month, 6 months or 12 months after surgery) and prognosis (DFS and OS). The correlation between BMI loss after sur...
Source: International Journal of Medical Sciences - September 16, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

The efficacy of intramuscular ephedrine in preventing hemodynamic perturbations in patients with spinal anesthesia and dexmedetomidine sedation.
This study investigated the effects of prophylactic intramuscular injection of ephedrine in preventing hypotension and bradycardia occurring through combined use of spinal anesthesia and dexmedetomidine. One hundred sixteen patients scheduled for lower extremity orthopedic surgery were randomized into two groups receiving either ephedrine 20 mg intramuscularly or equivalent amount of 0.9% NaCl, both with dexmedetomidine and spinal anesthesia. The primary endpoint was the incidence of hemodynamic perturbations (hypotension or bradycardia event). The secondary endpoint was a rescue doses of ephedrine and atropine. The incide...
Source: International Journal of Medical Sciences - September 16, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Sesamin inhibits cervical cancer cell proliferation by promoting p53/PTEN-mediated apoptosis.
Conclusions: These findings indicate that sesamin inhibits cervical cancer cell proliferation, and its mechanism may be attributed to the induction of p53/PTEN-mediated apoptosis. This suggests that sesamin might be useful as an adjuvant in promoting anti-cervical cancer treatments. PMID: 32922194 [PubMed - in process] (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - September 16, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Occult Hepatitis B Virus Infection in Maintenance Hemodialysis Patients: Prevalence and Mutations in "a" Determinant.
Conclusions: Our study clarifies the prevalence of OBI in MHD patients in Sichuan Province(4.2% in the test group, 2.1% in the overall dialysis cohort), and demonstrate the mutations of Q129R and M133S in the "a" determinant of HBsAg for the first time. PMID: 32922195 [PubMed - in process] (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - September 16, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Study of weight and body mass index on graft loss after transplant over 5 years of evolution.
The objective of this study was to study the obesity as well as its causes and consequences in kidney transplant patients. The sample population consisted of 282 renal transplant patients, 170 men and 112 women, 18-74 years of age, who were monitored over a period of five years. For the purposes of our research, the patients were divided into two groups: (1) normal weight 18.5 ≤ BMI
Source: International Journal of Medical Sciences - September 16, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Characterization and functional prediction of the microRNAs differentially expressed in a mouse model of concanavalin A-induced autoimmune hepatitis.
In conclusion, these differently expressed miRNAs seemed to be associated with the onset of AIH, and have the potential to serve as the new targets on the treatment of this disease. PMID: 32922197 [PubMed - in process] (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - September 16, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Downregulation of Cypher induces apoptosis in cardiomyocytes via Akt/p38 MAPK signaling pathway.
Conclusions: Downregulation of Cypher participates in the promotion of cardiomyocytes apoptosis through inhibiting Akt dependent pathway and enhancing p38 MAPK phosphorylation. These findings may provide a new potential therapeutic strategy for the treatment of DCM. PMID: 32922198 [PubMed - in process] (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - September 16, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

FABP1 and FABP2 as markers of diabetic nephropathy.
Conclusion: Our results suggest that FABP1 and FABP2 may be novel biomarkers of diabetic nephropathy. PMID: 32922199 [PubMed - in process] (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - September 16, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Conjugation of TLR7 Agonist Combined with Demethylation Treatment Improves Whole-Cell Tumor Vaccine Potency in Acute Myeloid Leukemia.
Conclusions: Conjugation of TLR7 agonist combined with up-regulation of tumor antigen expression improved the effectiveness of whole-cell tumor vaccine in AML. PMID: 32922200 [PubMed - in process] (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - September 16, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

CX3CL1 and CX3CR1 could be a relevant molecular axis in the pathophysiology of idiopathic pulmonary fibrosis.
In this study, we characterize for the first time the expression of CX3CL1 and its receptor in lung tissue from patients with IPF; and its effect on collagen production in IPF fibroblasts. We found that CX3CL1-CX3CR1 axis has a modified expression in the lung tissue, importantly this axis is expressed on fibroblasts, and CX3CL1 decreased the collagen production in pulmonary fibroblasts derived from IPF patients. PMID: 32922201 [PubMed - in process] (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - September 16, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Potential mechanism of RRM2 for promoting Cervical Cancer based on weighted gene co-expression network analysis.
This study aims to investigate the potential molecular mechanism of RRM2 for promoting the development of cervical cancer based on The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO). RRM2 was found to be significant upregulated in cervical tissue (P
Source: International Journal of Medical Sciences - September 16, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

CT features and outcomes of newly developed pulmonary lesions in patients with Coronavirus Disease 2019 (COVID-19).
This study aimed to determine whether new pulmonary lesions will develop after treatment in patients with COVID-19 pneumonia, and investigate their CT features and outcomes. Methods: This retrospective study included 56 consecutive patients with confirmed COVID-19 pneumonia from January 20 to March 5, 2020. Their initial and follow-up CT images and clinical data were reviewed. The CT manifestations of primary and newly developed pulmonary lesions and their changes after treatment were mainly evaluated. Results: Among the 56 patients (mean age: 48±15 years, 35 men) with COVID-19 pneumonia, 42 (75.0%) patients develop...
Source: International Journal of Medical Sciences - September 16, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Identifying the association between single nucleotide polymorphisms in KCNQ1, ARAP1, and KCNJ11 and type 2 diabetes mellitus in a Chinese population.
Authors: Li Y, Shen K, Li C, Yang Y, Yang M, Tao W, He S, Shi L, Yao Y Abstract Background: Type 2 diabetes mellitus (T2DM) has a high global prevalence, and insufficient insulin secretion is one of the major reasons for its development. Therefore, investigating the association between T2DM and the single nucleotide polymorphisms (SNPs) in genes associated with insulin secretion is necessary. Methods: T2DM (1,194) and nondiabetic (NDM) (1,292) subjects were enrolled and the ten single nucleotide polymorphisms (SNPs) in KCNQ1, ARAP1, and KCNJ11 associated with insulin secretion were genotyped in a Chinese population...
Source: International Journal of Medical Sciences - September 16, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

CHD1L promotes EOC cell invasiveness and metastasis via the regulation of METAP2.
Authors: He WP, Guo YY, Yang GP, Lai HL, Sun TT, Zhang ZW, Ouyang LL, Zheng Y, Tian LM, Li XH, You ZS, Xie D, Yang GF Abstract Chromodomain helicase DNA binding protein 1-like (CHD1L) gene has been proposed to play an oncogenic role in human hepatocellular carcinoma. Previously we reported that CHD1L overexpression is significantly associated with the metastasis proceeding of epithelial ovarian cancer (EOC), and may predict a poor prognosis in EOC patients. However, the potential oncogenic mechanisms by which CHD1L acts in EOC remain unclear. To elucidate the oncogenic function of CHD1L, we carried out a series of ...
Source: International Journal of Medical Sciences - September 16, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Foot health-related quality of life in hemophiliacs: A case-control study.
Authors: Jiménez-Cebrián AM, López-López D, Becerro-de-Bengoa-Vallejo R, Losa-Iglesias ME, Navarro-Flores E, San-Antolín M, Calvo-Lobo C, Palomo-López P Abstract Background: Haemophilia is considered as a chronic genetic disease related with alteration in coagulation mechanism which affects to health related quality of life (HQoL). Purpose: The goal compared marks of HQoL, in haemophiliacs with respect non haemophilic subjects. Methods: A population of 74 subjects, were recruited from association of haemophilic illness separated in haemophilic subjects (n = 37) and no haemo...
Source: International Journal of Medical Sciences - September 16, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Resveratrol reduces inflammation-related Prostate Fibrosis.
Authors: Vicari E, Arancio A, Catania VE, Vicari BO, Sidoti G, Castiglione R, Malaguarnera M Abstract Inflammation-related prostate fibrosis (PF) is strongly associated with impaired urethral function and lower urinary tract symptoms (LUTS) severity. The aim of this study was to investigate the effects of RSV in patients with small prostate volume and LUTS. Sixty-four patients with PF were randomized either to RSV therapy (group A= 32 patients) or placebo (group B= 32 patients). At baseline (T0) and after 2-months (T2), patients of both groups underwent administration of NIH-Chronic Prostatic Symptom Index (NIH-CPS...
Source: International Journal of Medical Sciences - August 14, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

New additional scoring formula on the Pathological Features in Stage I Lung Adenocarcinoma Patients: Impact on Survival.
Authors: Zhao S, Li F, Guo X, Guo T, Mizutani KI, Yamada S, Gu C, Uramoto H Abstract Background: Histological heterogeneity of lung adenocarcinoma may result in different prognosis among patients with the same TNM pathological stage. However, no objective evaluation system of lung adenocarcinoma based on pathological features has been widely accepted for assessing the prognosis. Methods: We retrospectively analyzed 179 patients with stage I lung adenocarcinoma after complete surgical resection. The pathological classification was according to the IASLC/ATS/ERS adenocarcinoma classifications, and the detailed abunda...
Source: International Journal of Medical Sciences - August 14, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

A Prognostic Model Based on the Immune-related Genes in Colon Adenocarcinoma.
Conclusions: Our present findings indicate that the prognostic model based on prognosis-related IRGs plays a crucial role in the clinical supervision and prognostic prediction of COAD patients at both molecular and cellular levels. PMID: 32788867 [PubMed - as supplied by publisher] (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - August 14, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Retinal dehydrogenase 5 (RHD5) attenuates metastasis via regulating HIPPO/YAP signaling pathway in Hepatocellular Carcinoma.
We examined the mRNA level of RDH5 by using q-PCR in hepatocellular carcinoma (HCC) and adjacent non-cancerous tissues. The proliferation rate of HCC cells was detected by MTS assay, and the invasive ability was examined by transwell and scratch wound assays. The YAP protein localization and expression were visualized by immunofluorescence in two different cell lines. CpG islands in the promoter region were predicted by using the methprimer database. Clinical characteristics of a patient cohort data came from The Cancer Genome Atlas database. RDH5 was significantly downregulated in hepatocellular carcinoma tissues, and low...
Source: International Journal of Medical Sciences - August 14, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Comparison of Chest CT Manifestations of Coronavirus Disease 2019 (COVID-19) and Pneumonia Associated with Lymphoma.
Authors: Wang S, Zheng Y, Wang Z, Yao X, Dong B, Liu H, Qu J Abstract Objective: To retrospectively compare the clinical features and chest computed tomography (CT) characteristics of coronavirus disease 2019 (COVID-19) and pneumonia in lymphoma patients. Materials and Methods: Ten lymphoma patients with pneumonia and 12 patients with COVID-19 infections were enrolled from January 15 to March 14, 2020. The clinical features were recorded. All pulmonary lesions on chest CT were assessed for location, shape, density and diffusion degree. Other typical CT features were also evaluated. Results: The most commonly observ...
Source: International Journal of Medical Sciences - August 14, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Epigallocatechin-3-gallate preconditioned Adipose-derived Stem Cells confer Neuroprotection in aging rat brain.
In this study, we have investigated the protective effect of adipose-derived mesenchymal stem cells (ADSCs) and the role of epigallocatechin gallate (EGCG) in enhancing this effect in aging cerebral cortex of rats. Further, we attempted to elucidate the molecular mechanism through which EGCG influences the protective effects of ADSC. ADSCs, co-cultured with EGCG, were injected into 20-month-old Wistar rats. Hematoxylin and eosin staining of the cerebral cortex revealed noticeable neurogenic activity and visible improvements in the integrity of the pre-frontal cortex tissue, compared to that in rats treated with ADSCs alone...
Source: International Journal of Medical Sciences - August 14, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Articulation recovery in ALS patients after lineage-negative adjuvant cell therapy - preliminary report.
Conclusions: The outcomes of the LIN- cell application in ALS treatment of articulatory organs are promising. The procedure proved to be safe and feasible. A short-lasting trophic effect of autologous LIN- administration could encourage repeated cell's application in order to sustain their beneficial effects, however this approach needs further investigation. PMID: 32788871 [PubMed - as supplied by publisher] (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - August 14, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Inhibiting Caspase-12 Mediated Inflammasome Activation protects against Oxygen-Glucose Deprivation Injury in Primary Astrocytes.
In conclusion, Z-ATAD-FMK protected astrocytes against OGD-induced cell death and inhibited NLPR3-inflammasome activation. Our results indicate that caspase-12 and its potential regulation of NLRP3 inflammasome activation might be a promising target for treatment of ischemic stroke. PMID: 32788872 [PubMed - as supplied by publisher] (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - August 14, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

The prognostic value of HGF-c-MET signaling pathway in Gastric Cancer: a study based on TCGA and GEO databases.
This study aimed to elucidate the expression level of HGF-c-MET in gastric cancer patients and to investigate the prognostic and diagnostic value of HGF-c-MET. In silico analysis of the TCGA and GEO database found that HGF and c-MET mRNA expression are significantly higher in gastric cancer tissues than those in peritumor tissues. Both higher mRNA expression of HGF and c-MET were associated with a poorer prognosis. c-MET expression was modulated by methylation in the promoter regions. HGF was positively correlated with CD8+ T cell, CD4+ T cell, macrophage, neutrophil and dendritic cell. Furthermore, functional enrichment a...
Source: International Journal of Medical Sciences - August 14, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

The effect of combined Epidural-general Anesthesia on Hemodynamic Instability during Pheochromocytoma and Paraganglioma Surgery: A multicenter retrospective cohort study.
Conclusions: The combined epidural-general anesthesia was not effective in attenuating hypertensive responses, but could have exacerbated intraoperative hypotension. These findings should be taken into account before selecting the anesthetic technique in pheochromocytoma and sympathetic paraganglioma surgery. PMID: 32788874 [PubMed - as supplied by publisher] (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - August 14, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research