METTL3 Promotes Osteogenic Differentiation of Human Periodontal Ligament Stem Cells through IGF2BP1-Mediated Regulation of Runx2 Stability
Int J Med Sci. 2024 Feb 4;21(4):664-673. doi: 10.7150/ijms.90485. eCollection 2024.ABSTRACTN6-Methyladenosine (m6A) has been reported to play a dynamic role in osteoporosis and bone metabolism. However, whether m6A is involved in the osteogenic differentiation of human periodontal ligament stem cells (hPDLSCs) remains unclear. Here, we found that methyltransferase-like 3 (METTL3) was up-regulated synchronously with m6A during the osteogenic differentiation of hPDLSCs. Functionally, lentivirus-mediated knockdown of METTL3 in hPDLSCs impaired osteogenic potential. Mechanistic analysis further showed that METTL3 knockdown dec...
Source: International Journal of Medical Sciences - March 11, 2024 Category: Biomedical Science Authors: Xuefei Sun Xiujiao Meng Yu Piao Shaojie Dong Qianqian Dong Source Type: research

Enhanced Diagnostic Efficiency of Endometrial Carcinogenesis and Progression in Women with Abnormal Uterine Bleeding through Peripheral Blood Cytokine Testing: A Multicenter Retrospective Cohort Study
Conclusions: Cytokines such as IL-4, IL-8, and IL-6 can serve as markers for monitoring endometrial cancer and its progression in women with abnormal uterine bleeding.PMID:38464838 | PMC:PMC10920852 | DOI:10.7150/ijms.91506 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - March 11, 2024 Category: Biomedical Science Authors: Jincheng Ma Dabin Liu Xiaodan Mao Leyi Huang Yuan Ren Xiaozhen Xu Xiaoli Huang Caiping Deng Feifeng Shi Pengming Sun Source Type: research

The DNA-dependent protein kinase catalytic subunit promotes sepsis-induced cardiac dysfunction through disrupting INF-2-dependent mitochondrial dynamics
This study examines the role of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and Inverted Formin 2 (INF2) in the pathogenesis of SIC, focusing on their impact on mitochondrial homeostasis and dynamics. Our research demonstrates that silencing DNA-PKcs alleviates lipopolysaccharide (LPS)-induced cardiomyocyte death and dysfunction. Using HL-1 cardiomyocytes treated with LPS, we observed that DNA-PKcs knockdown notably reverses LPS-induced cytotoxicity, indicating a protective role against cellular damage. This effect is further substantiated by the reduction in caspase-3 and caspase-9 activation, key markers of...
Source: International Journal of Medical Sciences - March 11, 2024 Category: Biomedical Science Authors: Mudi Ma Hao Zhou Ying Zhang Woliang Yuan Chaoxiong Chen Source Type: research

Development and validation of a diagnostic nomogram to evaluate tubular atrophy/interstitial fibrosis of IgA nephropathy
Conclusion: The eGFRcr-cys and UPE are associated with tubular atrophy or interstitial fibrosis in patients with IgAN. Diagnostic nomogram can predict tubular atrophy or interstitial fibrosis in IgAN.PMID:38464822 | PMC:PMC10920839 | DOI:10.7150/ijms.91804 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - March 11, 2024 Category: Biomedical Science Authors: Yangang Gan Yihuan Cai Jiajia Li Jianping Wu Rui Zhang Qianqian Han Wenchao Li Qiongqiong Yang Source Type: research

Proteomics-based Model for Predicting the Risk of Brain Metastasis in Patients with Resected Lung Adenocarcinoma carrying the EGFR Mutation
Conclusions: A predictive model based on protein markers was developed to accurately predict postoperative BM in operable LUAD harboring EGFR mutation.PMID:38464823 | PMC:PMC10920840 | DOI:10.7150/ijms.92993 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - March 11, 2024 Category: Biomedical Science Authors: Qiuhua Deng Fengnan Wang Lei Song Liangyu Chen Ying Huang Zhihua Guo Haihong Yang Source Type: research

Comparing the Long-Term Cardiovascular Outcomes of Lumbo-Peritoneal, Ventriculo-Peritoneal, or Non-Shunting Treatment after Idiopathic Normal Pressure Hydrocephalus: A Nationwide Retrospective Cohort Study
Conclusions: Based on these findings, we propose that the LPS is preferable to the VPS, and surgical treatment should be considered the primary choice over conservative treatment unless contraindications are present.PMID:38464824 | PMC:PMC10920851 | DOI:10.7150/ijms.92032 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - March 11, 2024 Category: Biomedical Science Authors: Cheng-Di Chiu Po-Fan Chiu Chih-Ying Wu Hei-Tung Yip You-Pen Chiu Hui-Ru Ji Kai-Cheng Hsu Fuu-Jen Tsai Robert Chen-Hao Chang Source Type: research

Oridonin inhibited epithelial-mesenchymal transition of laryngeal carcinoma by positively regulating LKB1/AMPK signaling
In conclusion, our study revealed that oridonin could remarkably reverse the epithelial-mesenchymal transition of laryngeal carcinoma by positively regulating LKB1/AMPK signaling pathway, which suggested that oridonin may be a potential candidate for the treatment of laryngeal carcinoma in the future.PMID:38464825 | PMC:PMC10920846 | DOI:10.7150/ijms.92182 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - March 11, 2024 Category: Biomedical Science Authors: Bo Kou Yuhan Shi Zhaoyue Zhou Yanning Yun Qun Wu Jinsong Zhou Wei Liu Source Type: research

PKM2 interacts with and phosphorylates PHB2 to sustain mitochondrial quality control against septic cerebral-cardiac injury
This study elucidates the regulatory role of the Pyruvate Kinase M2 (PKM2)- Prohibitin 2 (PHB2) axis in mitochondrial quality control during septic challenges and its protective effects against myocardial and cerebral injuries. Employing LPS-induced mouse models, we demonstrate a significant downregulation of PKM2 and PHB2 in both heart and brain tissues post-sepsis, with corresponding impairments in mitochondrial dynamics, including fission, fusion, and mitophagy. Overexpression of PKM2 and PHB2 not only restores mitochondrial function, as evidenced by normalized ATP production and membrane potential but also confers resi...
Source: International Journal of Medical Sciences - March 11, 2024 Category: Biomedical Science Authors: Yuanchen Zhao Yawen Pan Mengyuan Chen Ying Tan Xing Chang Haixia Li Yinghao Zhi Source Type: research

Rosmarinic Acid Protects Skin Keratinocytes from Particulate Matter 2.5-Induced Apoptosis
Conclusion: RA protected HaCaT cells from PM2.5-induced apoptosis by lowering oxidative stress.PMID:38464827 | PMC:PMC10920844 | DOI:10.7150/ijms.90814 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - March 11, 2024 Category: Biomedical Science Authors: Herath Mudiyanselage Udari Lakmini Herath Mei Jing Piao Kyoung Ah Kang Pincha Devage Sameera Madushan Fernando Jin Won Hyun Source Type: research

Ferroptosis: A New Mechanism in Diabetic Cardiomyopathy
Int J Med Sci. 2024 Jan 21;21(4):612-622. doi: 10.7150/ijms.88476. eCollection 2024.ABSTRACTDiabetic cardiomyopathy (DC) is a pathophysiologic condition caused by diabetes mellitus (DM) in the absence of coronary artery disease, valvular heart disease, and hypertension that can lead to heart failure (HF), manifesting itself in the early stages with left ventricular hypertrophy and diastolic dysfunction, with marked HF and decreased systolic function in the later stages. There is still a lack of direct evidence to prove the exact existence of DC. Ferroptosis is a novel form of cell death characterized by reactive oxygen spe...
Source: International Journal of Medical Sciences - March 11, 2024 Category: Biomedical Science Authors: Zichong Song Jingyi Wang Lijun Zhang Source Type: research

Hyperoside induces cell cycle arrest and suppresses tumorigenesis in bladder cancer through the interaction of EGFR-Ras and Fas signaling pathways
This study reveals that hyperoside could be a promising therapeutic strategy for the prevention of bladder cancer.PMID:38464829 | PMC:PMC10920848 | DOI:10.7150/ijms.90261 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - March 11, 2024 Category: Biomedical Science Authors: Kai Yang Zhi-Xiang Qi Ming-Xin Sun Li-Ping Xie Source Type: research

The Protein Acetylation after Traumatic Spinal Cord Injury: Mechanisms and Therapeutic Opportunities
In conclusion, a comprehensive understanding of protein acetylation and deacetylation in SCI may contribute to the development of SCI treatment.PMID:38464830 | PMC:PMC10920853 | DOI:10.7150/ijms.92222 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - March 11, 2024 Category: Biomedical Science Authors: Hong-Wei Li Hai-Hong Zhang Source Type: research

A comparative analysis of the doctoral regulations at the medical faculties in Germany
Conclusion: The analysis showed a divergent picture. Although imprecise regulations or gaps in information allow scope for design, they also prevent transparency. Despite revisions of many regulations in the past, these revisions have not led to any significant harmonisation. The implementation of standardised and structured doctoral programmes is desirable and could be tackled within the framework of the planned amendment of medical studies. This opens up the possibility of dealing efficiently with the scarce resource of time in the face of competing curriculum content and of making a doctoral project more attractive to p...
Source: International Journal of Medical Sciences - March 11, 2024 Category: Biomedical Science Authors: Sarah Altenberger Roman Leischik Richard Vollenberg Jan Peter Ehlers Markus Strauss Source Type: research

Impact of Omicron variant infection on the liver, kidney, and coagulation system in patients undergoing elective surgery: a retrospective case-control study
Conclusion: Compared with uninfected patients, patients who underwent elective surgery one month after Omicron variant infection exhibited minimal changes in perioperative coagulation parameters, liver function, CBC counts, and kidney function. Additionally, no significant differences in postoperative mortality or LOS were observed between the two groups.PMID:38464832 | PMC:PMC10920850 | DOI:10.7150/ijms.88727 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - March 11, 2024 Category: Biomedical Science Authors: Xiaojuan Xiong Rui Li Haoyu Pei Qingxiang Mao Source Type: research

Roxadustat Versus Erythropoietin: The Comparison of Efficacy in Reversing Ventricular Remodeling in Dialysis Patients with Anaemia
Conclusions: The increase of haemoglobin was associated with improving left ventricular hypertrophy in dialysis patients. However, the beneficial effects between roxadustat and recombinant human erythropoietin on left ventricular mass index did not show clear superiority or inferiority in six months.PMID:38464833 | PMC:PMC10920838 | DOI:10.7150/ijms.87870 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - March 11, 2024 Category: Biomedical Science Authors: Meng Ying Wang Xiao Qi Liu Ting Ting Jiang Wen Tao Liu Yang Huang Yu Lin Huang Feng Yong Jin Qing Zhao Qin Yi Wu Gui Hua Wang Xiong Zhong Ruan Kun Ling Ma Source Type: research