International Journal of Medical Sciences This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Hyperoside induces cell cycle arrest and suppresses tumorigenesis in bladder cancer through the interaction of EGFR-Ras and Fas signaling pathways
This study reveals that hyperoside could be a promising therapeutic strategy for the prevention of bladder cancer.PMID:38464829 | PMC:PMC10920848 | DOI:10.7150/ijms.90261 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - March 11, 2024 Category: Biomedical Science Authors: Kai Yang Zhi-Xiang Qi Ming-Xin Sun Li-Ping Xie Source Type: research

The Protein Acetylation after Traumatic Spinal Cord Injury: Mechanisms and Therapeutic Opportunities
In conclusion, a comprehensive understanding of protein acetylation and deacetylation in SCI may contribute to the development of SCI treatment.PMID:38464830 | PMC:PMC10920853 | DOI:10.7150/ijms.92222 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - March 11, 2024 Category: Biomedical Science Authors: Hong-Wei Li Hai-Hong Zhang Source Type: research

A comparative analysis of the doctoral regulations at the medical faculties in Germany
Conclusion: The analysis showed a divergent picture. Although imprecise regulations or gaps in information allow scope for design, they also prevent transparency. Despite revisions of many regulations in the past, these revisions have not led to any significant harmonisation. The implementation of standardised and structured doctoral programmes is desirable and could be tackled within the framework of the planned amendment of medical studies. This opens up the possibility of dealing efficiently with the scarce resource of time in the face of competing curriculum content and of making a doctoral project more attractive to p...
Source: International Journal of Medical Sciences - March 11, 2024 Category: Biomedical Science Authors: Sarah Altenberger Roman Leischik Richard Vollenberg Jan Peter Ehlers Markus Strauss Source Type: research

Impact of Omicron variant infection on the liver, kidney, and coagulation system in patients undergoing elective surgery: a retrospective case-control study
Conclusion: Compared with uninfected patients, patients who underwent elective surgery one month after Omicron variant infection exhibited minimal changes in perioperative coagulation parameters, liver function, CBC counts, and kidney function. Additionally, no significant differences in postoperative mortality or LOS were observed between the two groups.PMID:38464832 | PMC:PMC10920850 | DOI:10.7150/ijms.88727 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - March 11, 2024 Category: Biomedical Science Authors: Xiaojuan Xiong Rui Li Haoyu Pei Qingxiang Mao Source Type: research

Roxadustat Versus Erythropoietin: The Comparison of Efficacy in Reversing Ventricular Remodeling in Dialysis Patients with Anaemia
Conclusions: The increase of haemoglobin was associated with improving left ventricular hypertrophy in dialysis patients. However, the beneficial effects between roxadustat and recombinant human erythropoietin on left ventricular mass index did not show clear superiority or inferiority in six months.PMID:38464833 | PMC:PMC10920838 | DOI:10.7150/ijms.87870 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - March 11, 2024 Category: Biomedical Science Authors: Meng Ying Wang Xiao Qi Liu Ting Ting Jiang Wen Tao Liu Yang Huang Yu Lin Huang Feng Yong Jin Qing Zhao Qin Yi Wu Gui Hua Wang Xiong Zhong Ruan Kun Ling Ma Source Type: research

Comprehensive study on the differential extraction and comparison of bioactive health potential of the Broccoli ( < em > Brassica oleracea < /em > )
Conclusions: Acetonitrile and aqueous extraction of broccoli might be an ideal choice for extraction methods, which show increased extraction yield and antioxidant and anti-inflammatory potentials. Utilization of phytomolecules from natural sources is a promising alternative approach to synthetic drug development.PMID:38464834 | PMC:PMC10920836 | DOI:10.7150/ijms.92456 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - March 11, 2024 Category: Biomedical Science Authors: Durga Uvaraj Naiyf S Alharbi Shine Kadaikunnan Muthu Thiruvengadam Baskar Venkidasamy Source Type: research

Phosphoglycerate mutase 5 aggravates alcoholic liver disease through disrupting VDAC-1-dependent mitochondrial integrity
Int J Med Sci. 2024 Feb 25;21(4):755-764. doi: 10.7150/ijms.93171. eCollection 2024.ABSTRACTAlcoholic liver disease (ALD) poses a substantial global health challenge, with its pathogenesis deeply rooted in mitochondrial dysfunction. Our study explores the pivotal roles of Phosphoglycerate mutase family member 5 (Pgam5) and Voltage-Dependent Anion Channel 1 (VDAC1) in the progression of ALD, providing novel insights into their interplay and impact on mitochondrial integrity. We demonstrate that Pgam5 silencing preserves hepatocyte viability and attenuates ethanol-induced apoptosis, underscoring its detrimental role in exace...
Source: International Journal of Medical Sciences - March 11, 2024 Category: Biomedical Science Authors: Tian Xia Jiachi Yu Ye Chen Xing Chang Miao Meng Source Type: research

Effects of Banhabaekchulcheonma-Tang on Brain Injury and Cognitive Function Impairment Caused by Bilateral Common Carotid Artery Stenosis in a Mouse Model
Int J Med Sci. 2024 Jan 21;21(4):644-655. doi: 10.7150/ijms.90167. eCollection 2024.ABSTRACTVascular dementia (VD) is the second most prevalent dementia type, with no drugs approved for its treatment. Here, the effects of Banhabaekchulcheonma-Tang (BBCT) on ischemic brain injury and cognitive function impairment were investigated in a bilateral carotid artery stenosis (BCAS) mouse model. Mice were divided into sham-operated, BCAS control, L-BBCT (40 ml/kg), and H-BBCT (80 ml/kg) groups. BBCT's effects were characterized using the Y-maze test, novel object recognition test (NORT), immunofluorescence staining, RNA sequencing...
Source: International Journal of Medical Sciences - March 11, 2024 Category: Biomedical Science Authors: Da-Woon Kim Jung-Hwa Lim Suin Cho Sang-Ho Kim Source Type: research

METTL3 Promotes Osteogenic Differentiation of Human Periodontal Ligament Stem Cells through IGF2BP1-Mediated Regulation of Runx2 Stability
Int J Med Sci. 2024 Feb 4;21(4):664-673. doi: 10.7150/ijms.90485. eCollection 2024.ABSTRACTN6-Methyladenosine (m6A) has been reported to play a dynamic role in osteoporosis and bone metabolism. However, whether m6A is involved in the osteogenic differentiation of human periodontal ligament stem cells (hPDLSCs) remains unclear. Here, we found that methyltransferase-like 3 (METTL3) was up-regulated synchronously with m6A during the osteogenic differentiation of hPDLSCs. Functionally, lentivirus-mediated knockdown of METTL3 in hPDLSCs impaired osteogenic potential. Mechanistic analysis further showed that METTL3 knockdown dec...
Source: International Journal of Medical Sciences - March 11, 2024 Category: Biomedical Science Authors: Xuefei Sun Xiujiao Meng Yu Piao Shaojie Dong Qianqian Dong Source Type: research

Enhanced Diagnostic Efficiency of Endometrial Carcinogenesis and Progression in Women with Abnormal Uterine Bleeding through Peripheral Blood Cytokine Testing: A Multicenter Retrospective Cohort Study
Conclusions: Cytokines such as IL-4, IL-8, and IL-6 can serve as markers for monitoring endometrial cancer and its progression in women with abnormal uterine bleeding.PMID:38464838 | PMC:PMC10920852 | DOI:10.7150/ijms.91506 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - March 11, 2024 Category: Biomedical Science Authors: Jincheng Ma Dabin Liu Xiaodan Mao Leyi Huang Yuan Ren Xiaozhen Xu Xiaoli Huang Caiping Deng Feifeng Shi Pengming Sun Source Type: research

The DNA-dependent protein kinase catalytic subunit promotes sepsis-induced cardiac dysfunction through disrupting INF-2-dependent mitochondrial dynamics
This study examines the role of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and Inverted Formin 2 (INF2) in the pathogenesis of SIC, focusing on their impact on mitochondrial homeostasis and dynamics. Our research demonstrates that silencing DNA-PKcs alleviates lipopolysaccharide (LPS)-induced cardiomyocyte death and dysfunction. Using HL-1 cardiomyocytes treated with LPS, we observed that DNA-PKcs knockdown notably reverses LPS-induced cytotoxicity, indicating a protective role against cellular damage. This effect is further substantiated by the reduction in caspase-3 and caspase-9 activation, key markers of...
Source: International Journal of Medical Sciences - March 11, 2024 Category: Biomedical Science Authors: Mudi Ma Hao Zhou Ying Zhang Woliang Yuan Chaoxiong Chen Source Type: research

Development and validation of a diagnostic nomogram to evaluate tubular atrophy/interstitial fibrosis of IgA nephropathy
Conclusion: The eGFRcr-cys and UPE are associated with tubular atrophy or interstitial fibrosis in patients with IgAN. Diagnostic nomogram can predict tubular atrophy or interstitial fibrosis in IgAN.PMID:38464822 | PMC:PMC10920839 | DOI:10.7150/ijms.91804 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - March 11, 2024 Category: Biomedical Science Authors: Yangang Gan Yihuan Cai Jiajia Li Jianping Wu Rui Zhang Qianqian Han Wenchao Li Qiongqiong Yang Source Type: research

Proteomics-based Model for Predicting the Risk of Brain Metastasis in Patients with Resected Lung Adenocarcinoma carrying the EGFR Mutation
Conclusions: A predictive model based on protein markers was developed to accurately predict postoperative BM in operable LUAD harboring EGFR mutation.PMID:38464823 | PMC:PMC10920840 | DOI:10.7150/ijms.92993 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - March 11, 2024 Category: Biomedical Science Authors: Qiuhua Deng Fengnan Wang Lei Song Liangyu Chen Ying Huang Zhihua Guo Haihong Yang Source Type: research

Comparing the Long-Term Cardiovascular Outcomes of Lumbo-Peritoneal, Ventriculo-Peritoneal, or Non-Shunting Treatment after Idiopathic Normal Pressure Hydrocephalus: A Nationwide Retrospective Cohort Study
Conclusions: Based on these findings, we propose that the LPS is preferable to the VPS, and surgical treatment should be considered the primary choice over conservative treatment unless contraindications are present.PMID:38464824 | PMC:PMC10920851 | DOI:10.7150/ijms.92032 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - March 11, 2024 Category: Biomedical Science Authors: Cheng-Di Chiu Po-Fan Chiu Chih-Ying Wu Hei-Tung Yip You-Pen Chiu Hui-Ru Ji Kai-Cheng Hsu Fuu-Jen Tsai Robert Chen-Hao Chang Source Type: research

Oridonin inhibited epithelial-mesenchymal transition of laryngeal carcinoma by positively regulating LKB1/AMPK signaling
In conclusion, our study revealed that oridonin could remarkably reverse the epithelial-mesenchymal transition of laryngeal carcinoma by positively regulating LKB1/AMPK signaling pathway, which suggested that oridonin may be a potential candidate for the treatment of laryngeal carcinoma in the future.PMID:38464825 | PMC:PMC10920846 | DOI:10.7150/ijms.92182 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - March 11, 2024 Category: Biomedical Science Authors: Bo Kou Yuhan Shi Zhaoyue Zhou Yanning Yun Qun Wu Jinsong Zhou Wei Liu Source Type: research