Association of sodium-glucose cotransporter 2 inhibitors with the incidence of corneal diseases in type 2 diabetes mellitus
In conclusion, the usage of SGLT2 inhibitors correlates to lower incidence of superficial keratopathy and infectious keratitis in T2DM individuals, which is more significant in patients with persistent SGLT2 inhibitors application.PMID:38322591 | PMC:PMC10845264 | DOI:10.7150/ijms.91571 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - February 7, 2024 Category: Biomedical Science Authors: Tsan-Yu Tsai Po-Jen Yang Shih-Chun Chao Chia-Yi Lee Jing-Yang Huang Shun-Fa Yang Hung-Yu Lin Source Type: research

Dual-specificity phosphatase 1 interacts with prohibitin 2 to improve mitochondrial quality control against type-3 cardiorenal syndrome
Int J Med Sci. 2024 Jan 19;21(3):547-561. doi: 10.7150/ijms.90484. eCollection 2024.ABSTRACTType-3 cardiorenal syndrome (CRS-3) is acute kidney injury followed by cardiac injury/dysfunction. Mitochondrial injury may impair myocardial function during CRS-3. Since dual-specificity phosphatase 1 (DUSP1) and prohibitin 2 (PHB2) both promote cardiac mitochondrial quality control, we assessed whether these proteins were dysregulated during CRS-3-related cardiac depression. We found that DUSP1 was downregulated in heart tissues from a mouse model of CRS-3. DUSP1 transgenic (DUSP1Tg) mice were protected from CRS-3-induced myocardi...
Source: International Journal of Medical Sciences - February 7, 2024 Category: Biomedical Science Authors: Nanyang Liu Yanqiu Ding Hao Zhou Xing Chang Long Lou Source Type: research

Predictive Value of CFIm25 Expression in Peripheral Blood Monocytes for Coronary Atherosclerosis
Conclusions: CFIm25 expression in peripheral blood monocytes correlates negatively with the degree of coronary atherosclerosis and helps predict the severity and number of coronary artery lesions.PMID:38322593 | PMC:PMC10845263 | DOI:10.7150/ijms.91148 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - February 7, 2024 Category: Biomedical Science Authors: Meng Liu Xiaoxiao Chen Zhan Gu Hao He Mingyue Chen Lin Kuai Zhiqiang Jia Yi Li Yizhou Chen Mei Hong Fangping Xiao Source Type: research

Text Mining and Drug Discovery Analysis: A Comprehensive Approach to Investigate Diabetes-Induced Osteoporosis
Conclusion: This study unveils ANDECALIXIMAB, SILTUXIMAB, OLOKIZUMAB, SECUKINUMAB, and IXEKIZUMAB as promising potential drugs for DOP treatment, demonstrating the significance of utilizing text mining and pathway analysis to investigate disease mechanisms and explore existing therapeutic options.PMID:38250601 | PMC:PMC10797669 | DOI:10.7150/ijms.90829 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - January 22, 2024 Category: Biomedical Science Authors: Chenfeng Wang Yihe Hu Feng Liang Source Type: research

Prescription of glucagon-like peptide 1 agonists and risk of subsequent open-angle glaucoma in individuals with type 2 diabetes mellitus
Conclusion: The prescription of GLP-1RA is associated with a lower incidence of subsequent OAG in individuals with T2DM, and this association was more significant in patients with T2DM under the age of 60 years.PMID:38250602 | PMC:PMC10797676 | DOI:10.7150/ijms.90273 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - January 22, 2024 Category: Biomedical Science Authors: Chih-Chun Chuang Kai Wang Chao-Kai Chang Chia-Yi Lee Jing-Yang Huang Heng-Hsiung Wu Po-Jen Yang Shun-Fa Yang Source Type: research