Activation of GABAA receptors enhances the behavioral recovery but not axonal sprouting in ischemic rats.
CONCLUSIONS: Our study revealed that infusion of muscimol into the contralateral motor cortex during the repair stage could partially improve the behavioral performances without promoting axonal growth from uninjured hemisphere motor cortex to the denervated striatum and spinal cord, nor did it prevent the expression of axonal growth inhibitors in peri-lesioned cortex. More detailed studies will be required to clarify the role of GABAA Rs in regulating the behavioral recovery after a stroke. PMID: 31227671 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - June 24, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Histone H1 improves regeneration after mouse spinal cord injury and changes shape and gene expression of cultured astrocytes.
CONCLUSIONS: The combined observations indicate that histone H1 locally applied to the lesion site, improves regeneration after spinal cord injury. Some of these beneficial functions of histone H1 in vivo and in vitro can be attributed to its interaction with PSA-carrying neural cell adhesion molecule. PMID: 31227672 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - June 24, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Efficacy, safety, and tolerability of bilateral transcranial direct current stimulation combined to a resistance training program in chronic stroke survivors: A double-blind, randomized, placebo-controlled pilot study.
CONCLUSIONS: In this pilot study, repeated sessions of bi-hemispheric tDCS coupled with resistance training were found safe and tolerable for individuals at the chronic phase post-stroke. However, the use of tDCS did not result in additional sensorimotor improvements when compared to sham-tDCS. Further research is needed to better assess the clinical benefits of combining non-invasive transcranial stimulation with rehabilitation after a stroke. PMID: 31227673 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - June 24, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

A N400 ERP Study in letter recognition after passive tactile stimulation training in blind children and sighted controls.
CONCLUSIONS: Blind children learn to recognize SSD-delivered letters better than seeing controls and had greater N400 amplitude in the occipital region. To the best of our knowledge, our results provide the first published example of standard letter recognition (not Braille) by children with blindness using a tactile delivery system. PMID: 31227674 [PubMed - in process] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - June 24, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Time course of sensorimotor cortex reorganization during upper extremity task accompanying motor recovery early after stroke: An fNIRS study.
This study aimed to assess the time course of hemodynamic patterns of cortical sensorimotor areas using functional near infrared spectroscopy (fNIRS) and motor recovery within three months after a stroke. METHOD: Eight right-handed first ischemic/hemorrhagic stroke patients (60±8 years, 3 women) with mild to severe hemiparesis were examined with repetitive fNIRS measurements and motor recovery tests (Fugl-Meyer score) during two months. Hemodynamic changes over the ipsilesional and contralesional sensorimotor areas were collected from a multi-channel fNIRS system during intermittent isometric muscle contractions...
Source: Restorative Neurology and Neuroscience - June 24, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

The effects of five sessions of continuous theta burst stimulation over contralesional sensorimotor cortex paired with paretic skilled motor practice in people with chronic stroke.
CONCLUSIONS: Multiple sessions of STT practice can improve paretic arm function and decrease TCI bilaterally, with no additional benefit of prior cTBS. Our results suggest that improvement in STT practice following M1c cTBS scaled with change in paretic arm function in some individuals. Our results highlight the need for a better understanding of the mechanisms of cTBS to effectively identify who may benefit from this form of brain stimulation. PMID: 31227676 [PubMed - in process] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - June 24, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Effects and safety of combined rTMS and action observation for recovery of function in the upper extremities in stroke patients: A randomized controlled trial.
CONCLUSIONS: Distal upper extremity function, as measured by MFT and grip power, was improved after rTMS and AO in combination. The combination of rTMS with AO may be applied safely to improve upper extremity function after stroke. PMID: 31177248 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - June 11, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Functional electrical stimulation improves reaching movement in the shoulder and elbow muscles of stroke patients: A three-dimensional motion analysis.
CONCLUSIONS: Functional electrical stimulation improved reaching movement in stroke patients with upper limb impairment. PMID: 31177249 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - June 11, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Improvement of motor performance in children with cerebral palsy treated with exoskeleton robotic training: A retrospective explorative analysis.
CONCLUSIONS: Our preliminary study suggests that RAGT combined with conventional treatment may improve motor performance and endurance in children with CP. Future randomized controlled trials comparing RAGT to conventional treatment are needed. PMID: 31177250 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - June 11, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Acute and chronic effects of single dose memantine after controlled cortical impact injury in adult rats.
CONCLUSIONS: Administration of memantine at a clinically-relevant delay after moderate-severe CCI injury has beneficial effects on acute outcomes, while more significant improvement on subacute and chronic outcomes may require repeated drug administration or its combination with another therapy. PMID: 31177251 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - June 11, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Expression patterns and functional evaluation of RGMa during the early phase of peripheral nerve regeneration using the mouse median nerve model.
CONCLUSIONS: Employing the mouse median nerve model in transgenic animals, we demonstrate that RGMa plays an important role during peripheral nerve regeneration. PMID: 31177252 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - June 11, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Immediate improvement of speech-in-noise perception through multisensory stimulation via an auditory to tactile sensory substitution.
CONCLUSIONS: These results are especially relevant when compared to previous SSD studies showing effects in behavior only after a demanding cognitive training. We discuss the implications of our results for development of SSDs and of specific rehabilitation programs for the hearing impaired either using or not using HAs or CIs. We also discuss the potential application of such a set-up for sense augmentation, such as when learning a new language. PMID: 31006700 [PubMed - in process] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - April 23, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Effect of surgically guided axonal regrowth into a 3-way-conduit (isogeneic trifurcated aorta) on functional recovery after facial-nerve reconstruction: Experimental study in rats.
CONCLUSIONS: The use of 3-way-conduit provides no advantages to classic coaptation. Should the latter be impossible (too large interstump defects requiring too long interpositional nerve grafts), this type of reconstruction may be applied. (230 words). PMID: 31006701 [PubMed - in process] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - April 23, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Cerebellar fastigial nucleus electrical stimulatin protects against cerebral ischemic damage by upregulating telomerase activity.
Authors: Zhang L, Li S, Chen L, Li J, Zhang Z, Yang Y, Wang X, Liu J Abstract BACKGROUND: Cerebellar fastigial nucleus electrical stimulation (FNS) in rats has been shown to protect against brain ischemia/reperfusion (I/R) damage. Activation of telomerase has been reported to provide neuroprotection in animal models of stroke. OBJECTIVE: The aim of this study was to explore whether precondition FNS increases the expression of telomerase reverse transcriptase (TERT) and telomerase activity in rats after cerebral I/R injury. METHODS: One day after continuous stimulation of the fastigial cerebellar nucleus for...
Source: Restorative Neurology and Neuroscience - April 18, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Investigations on maladaptive plasticity in the sensorimotor cortex of unilateral upper limb CRPS I patients.
CONCLUSIONS: This study is the first to gather behavioral, neurophysiologic and imaging measurements for one patient cohort and it therefore enables a comprehensive view of collapsed associations of function and representation focused on the hemisphere contralateral to the affected hand. PMID: 30988242 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - April 18, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Effects of two different protocols of cerebellar transcranial direct current stimulation combined with transcutaneous spinal direct current stimulation on robot-assisted gait training in patients with chronic supratentorial stroke: A single blind, randomized controlled trial.
Conclusions: Our findings support the hypothesis that cathodal transcranial direct current stimulation over the contralesional or ipsilesional cerebellar hemisphere in combination with cathodal transcutaneous spinal direct current stimulation may lead to similar effects on robotic gait training in chronic supratentorial stroke patients. PMID: 30958319 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - April 9, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Clinical improvement with intensive robot-assisted arm training in chronic stroke is unchanged by supplementary tDCS.
Authors: Edwards DJ, Cortes M, Rykman-Peltz A, Chang J, Elder J, Thickbroom G, Mariman JJ, Gerber LM, Oromendia C, Krebs HI, Fregni F, Volpe BT, Pascual-Leone A Abstract BACKGROUND: Intensive robot-assisted arm training in the chronic phase of stroke recovery can lead to clinical improvement. Combinatorial therapeutic approaches are sought to further optimize stroke recovery. Transcranial direct current stimulation (tDCS) is one candidate to combine with robotic training, as transient increases in excitability and improvements in motor behavior have separately been reported. OBJECTIVE: To determine whether tDCS...
Source: Restorative Neurology and Neuroscience - April 3, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Can robot-based measurements improve prediction of motor performance after robot-assisted upper-limb rehabilitation in patients with moderate-to-severe sub-acute stroke?
Authors: Duret C, Pila O, Grosmaire AG, Koeppel T Abstract PURPOSE: Patients with moderate-to-severe stroke-related upper limb impairment can benefit from repetitive robot-assisted training. However, predicting motor performance in these patients from baseline measurements, including robot-based parameters would help clinicians to provide optimal treatments for each individual. METHODS: Forty-six patients with sub-acute stroke underwent a 16-session upper limb rehabilitation combining usual care and robotic therapy. Motor outcomes (Fugl-Meyer Assessment Upper Extremity (FMA) score) were retrospectively analysed...
Source: Restorative Neurology and Neuroscience - March 27, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Focal traumatic brain injury induces neuroplastic molecular response in lumbar spinal cord.
CONCLUSIONS: The results support the hypothesis that focal TBI induces plastic alterations in the lumbar spinal cord that may contribute to either motor recovery or maladaptive motor responses. PMID: 30856132 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - March 13, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

No effects of anodal transcranial direct current stimulation on contrast sensitivity function.
CONCLUSIONS: The anodal tDCS, at least with two sessions, has no effect on modulating CSF. The absence of anodal tDCS effect on CSF was not due to subject's responsiveness to tDCS or measurement precision. More studies were needed to determine the optimal vision modulation configuration. PMID: 30856133 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - March 13, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Is a combination of progesterone and chloroquine more effective than either alone in the treatment of cerebral ischemic injury?
CONCLUSIONS: Our findings suggest that combination therapy with P4 and CQ is not detrimental and has a small-to-moderate additive neuroprotective effect on ischemic injury in rats without substantively affecting behavioral outcomes. CQ and P4 may help to regulate the expression of both autophagy-related and apoptosis-related proteins. PMID: 30741704 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - February 13, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Cognitive strategy on upper extremity function for stroke: A randomized controlled trials.
Authors: Song CS, Lee ON, Woo HS Abstract BACKGROUND: Cognitive orientation to daily occupational performance (CO-OP) is a task-specific training applied using a cognitive behavioral approach to improve performance in daily activities and to enable the patient to overcome limitations related to them. OBJECTIVES: The purpose of this study was to investigate the effects of the CO-OP approach in comparison with task-specific upper extremity training (TUET) on performance related to daily and functional activities in individuals with chronic hemiparetic stroke. METHODS: Forty-nine participants diagnosed with st...
Source: Restorative Neurology and Neuroscience - February 13, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Frontal lobe function, behavioral changes and quality of life in patients with multiple system atrophy.
The objective of the study was to explore the potential relationships among frontal lobe function, behavioral changes and quality of life (QoL) in patients with MSA. METHODS: A total of 203 MSA patients were enrolled and evaluated using the Frontal Assessment Battery (FAB), the Frontal Behavioral Inventory (FBI) and the Parkinson's disease Questionnaire-39 item version (PDQ-39). Seventy-eight age-, sex-, and education-matched healthy controls were recruited to complete the FAB. RESULTS: Among MSA patients, those with frontal lobe dysfunction were older (P = 0.005), had older age of onset (P = 0.002), lower ...
Source: Restorative Neurology and Neuroscience - February 13, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Vanillin ameliorates changes in HIF-1 α expression and neuronal apoptosis in a rat model of spinal cord injury.
Vanillin ameliorates changes in HIF-1α expression and neuronal apoptosis in a rat model of spinal cord injury. Restor Neurol Neurosci. 2019 Feb 04;: Authors: Chen H, Zheng J, Ma J Abstract BACKGROUND: In the search for treating neurological dysfunctions after spinal cord injury (SCI), methods of neuroprotection are of interest to intervene with the caspase pathway. OBJECTIVE: To evaluate the neuroprotective effects of vanillin in a rat model of spinal cord injury (SCI). METHODS: Rats were randomly assigned to one of three groups: a sham-operated group, and two groups where SCI was produce...
Source: Restorative Neurology and Neuroscience - February 13, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Dynamic cognitive remediation for a Traumatic Brain Injury (TBI) significantly improves attention, working memory, processing speed, and reading fluency.
CONCLUSIONS: Remediating visual timing deficits in the dorsal stream revealed the causal role of visual movement discrimination training in improving high-level cognitive functions such as focusing and switching attention, working memory, processing speed, and reading. This study found that movement-discrimination training was very rapid and effective in remediating cognitive deficits, providing a new approach that is very beneficial for treating a mild TBI. PMID: 30741708 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - February 13, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Transient visual field impairment after cold provocation in glaucoma patients with Flammer syndrome.
CONCLUSIONS: Cold provocation induced a transient visual field deterioration in the glaucoma patients with FS but not in the glaucoma patients without FS or in the healthy controls. We assume this effect to be the result of a transient reduction of ocular blood flow. PMID: 30741709 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - February 13, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Impact of yoga based mind-body intervention on systemic inflammatory markers and co-morbid depression in active Rheumatoid arthritis patients: A  randomized controlled trial.
Impact of yoga based mind-body intervention on systemic inflammatory markers and co-morbid depression in active Rheumatoid arthritis patients: A randomized controlled trial. Restor Neurol Neurosci. 2019 Feb 01;: Authors: Gautam S, Tolahunase M, Kumar U, Dada R Abstract BACKGROUND: Recovery of the patients with rheumatoid arthritis (RA) depends on several physical and psychological factors, besides pharmacological treatment. Co-morbid depression adversely affects the outcome in RA. Usual medical therapies have a limited scope and fail to cure the psychological component of the disease. With advance...
Source: Restorative Neurology and Neuroscience - February 6, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Rapid improvement of reading performance in children with dyslexia by altering the reading strategy: A novel approach to diagnoses and therapy of reading deficiencies.
Authors: Werth R Abstract BACKGROUND: Reading disability is termed "dyslexia" if it is much lower than other cognitive abilities according to the intelligence quotient (IQ). This means that dyslexia is caused by an impairment of abilities other than those which the IQ requires. Therefore, reading performance should improve immediately if these impairments are either eliminated or compensated. OBJECTIVE: The experiments explore conditions under which these impairments are compensated and dyslexic children's poor reading ability immediately improve. METHODS: Experiment 1 examined if reducing the num...
Source: Restorative Neurology and Neuroscience - November 11, 2018 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Vestibular rehabilitation has positive effects on balance, fatigue and activities of daily living in highly disabled multiple sclerosis people: A preliminary randomized controlled trial.
Authors: Tramontano M, Cinnera AM, Manzari L, Tozzi F, Caltagirone C, Morone G, Pompa A, Grasso MG Abstract BACKGROUND: Balance disorders are present in patients with Multiple Sclerosis and part of these disorders could be of vestibular origin. Vestibular Rehabilitation was found to be effective in improving balance in patients with central vestibular dysfunction. OBJECTIVE: To investigate the clinical effects of vestibular rehabilitation on balance skills and secondly on fatigue and activity of daily living in highly disabled multiple sclerosis people. METHODS: Thirty hospitalized participants with severe ...
Source: Restorative Neurology and Neuroscience - November 11, 2018 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Randomized, crossover, sham-controlled, double-blind study of transcranial direct current stimulation of left DLPFC on executive functions  .
CONCLUSIONS: Offline tDCS has limited impact on executive functions at both the task and factorial levels. This suggests that reducing task impurity does not increase the effectiveness of tDCS in modulating cognitive functions. PMID: 30412514 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - November 11, 2018 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Residual vision activation and the brain-eye-vascular triad: Dysregulation, plasticity and restoration in low vision and blindness - a review.
Authors: Sabel BA, Flammer J, Merabet LB Abstract Vision loss due to ocular diseases such as glaucoma, optic neuropathy, macular degeneration, or diabetic retinopathy, are generally considered an exclusive affair of the retina and/or optic nerve. However, the brain, through multiple indirect influences, has also a major impact on functional visual impairment. Such indirect influences include intracerebral pressure, eye movements, top-down modulation (attention, cognition), and emotionally triggered stress hormone release affecting blood vessel dysregulation. Therefore, vision loss should be viewed as the result of ...
Source: Restorative Neurology and Neuroscience - November 11, 2018 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Self-powered robots to reduce motor slacking during upper-extremity rehabilitation: a proof of concept study.
CONCLUSIONS: Our findings provide novel evidence indicating that motor slacking can be reduced by self-powered robots; thus demonstrating promise for rehabilitation of impaired subjects using this new class of wearable system. The results also serve as a foundation to develop more sophisticated body-powered robots (e.g., with controllable transmissions) for rehabilitation purposes. PMID: 30400120 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - November 9, 2018 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Alterations in the spinal cord and ventral root after cerebral infarction in non-human primates.
CONCLUSIONS: These results indicate that focal cerebral infarction leads to pathological alterations in the spinal cord and ventral roots in non-human primates. PMID: 30400121 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - November 9, 2018 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Mediation improves brain oxygenation and quality of life in patients with primary open angle glaucoma: A randomized controlled trial.
Authors: Gagrani M, Faiq MA, Sidhu T, Dada R, Yadav RK, Sihota R, Kochhar KP, Verma R, Dada T Abstract BACKGROUND: Glaucoma (POAG) is a kind of neurodegenerative disease known to be closely associated with stress and adverse quality of life (QOL). Stress has also been shown to be involved in etiopathogenesis of primary open angle glaucoma (POAG). Complementary treatment in form of mindfulness based stress reduction (MBSR) has been reported to improve QOL, brain oxygenation and decrease markers of stress. With this premise, a randomized controlled trial was carried out to assess the effect of MBSR on intraocular pre...
Source: Restorative Neurology and Neuroscience - November 9, 2018 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Recovery from apraxic deficits and its neural correlate.
CONCLUSIONS: Data suggest that lesions affecting the core regions (and white matter) of the fronto-parietal network cause more persistent apraxic deficits than lesions affecting other regions (here: the left insula) that also contribute to motor cognition and apraxic deficits. PMID: 30282379 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - October 6, 2018 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Alterations in mitochondrial membrane potential in peripheral blood mononuclear cells in Parkinson's Disease: Potential for a novel biomarker.
CONCLUSIONS: Mitochondrial membrane potential is altered and hence its evaluation in peripheral blood mononuclear cells may serve as an early marker of apoptosis in PD and, therefore, may pave way for early interventions. Since Δψ has a role in the maintenance of electrochemical gradient - the disruption of which may lead to neuronal apoptosis, Δψ is intricately nested within etiopathogenesis of PD and may prove to be useful in design of diagnostics, prognostics and therapeutics for PD. PMID: 30282380 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - October 6, 2018 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Protective effect of roscovitine against rotenone-induced parkinsonism.
CONCLUSIONS: Mouse models of Parkinson's disease were established by oral rotenone administration and reproduced some of the features of dopaminergic neuronal degeneration. Roscovitine protects against rotenone-induced parkinsonism. PMID: 30056439 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - July 31, 2018 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Investigating the interference pattern of dual tasks using serial decomposition.
CONCLUSIONS: The % DT/DT is significantly higher than both % CT/DT and % MT/DT, which suggests that the cognitive load depends on the type of cognitive task that is being performed. Additionally, the significant increase of % DT/DT compared to % CT/DT indicated that there is a cognitive load prior to a motor task. The increased button shifting time and decreased tapping rate in DT may indicate that a residual cognitive load and a concurrent motor load were present. PMID: 30056440 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - July 31, 2018 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Pretreatment of nerve grafts with resveratrol improves axonal regeneration following replantation surgery for nerve root avulsion injury in rats.
CONCLUSIONS: Resveratrol may promote axonal regeneration following replantation surgery for the treatment of nerve root avulsion injury; however, further studies are required to verify these findings in humans. PMID: 30056441 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - July 31, 2018 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Transcranial direct current stimulation of the primary motor cortex on postoperative pain and spontaneous oscillatory electroencephalographic activity following lumbar spine surgery: A pilot study.
Authors: Jiang N, Li G, Wei J, Wei B, Zhu FF, Hu Y Abstract BACKGROUND: Transcranial direct current stimulation (tDCS) on primary motor cortex (M1) provides a new way to relieve postoperative pain. Previous studies only found postoperative analgesia dosage significantly reduced in tDCS group while the patient-controlled analgesia (PCA) was applied. However, there lacks the study about the effect of M1-tDCS on pain intensity and brain activity while the analgesia dosage is the same for both groups. OBJECTIVE: To investigate whether M1-tDCS can (1) reduce pain intensity and (2) change spontaneous electroencephalo...
Source: Restorative Neurology and Neuroscience - July 25, 2018 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Eugenol promotes functional recovery and alleviates inflammation, oxidative stress, and neural apoptosis in a rat model of spinal cord injury.
CONCLUSIONS: These findings suggest that down-regulating NF-κB and MAPK signaling pathway may support the neuroprotective effect of Eugenol against traumatic SCI. PMID: 30040768 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - July 25, 2018 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Adipose-derived stem cell conditioned medium impacts asymptomatic peripheral neuromuscular denervation in the mutant superoxide dismutase (G93A) transgenic mouse model of amyotrophic lateral sclerosis.
Authors: Walker LC, Meadows MR, Du Y, March LK, Jones JK Abstract BACKGROUND: Amyotrophic lateral sclerosis (ALS) is devastating, leading to paralysis and death. Disease onset begins pre-symptomatically through spinal motor neuron (MN) axon die-back from musculature at ∼47 days of age in the mutant superoxide dismutase 1 (mSOD1G93A) transgenic ALS mouse model. This period may be optimal to assess potential therapies. We previously demonstrated that post-symptomatic adipose-derived stem cell conditioned medium (ASC-CM) treatment is neuroprotective in mSOD1G93A mice. We hypothesized that early disease onset treat...
Source: Restorative Neurology and Neuroscience - July 18, 2018 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Curcumin alleviates lipopolysaccharide-induced neuroinflammation in fetal mouse brain.
CONCLUSIONS: Our study in animal models indicates that maternal administration of curcumin alleviates neuroinflammation in the fetal brain caused by LPS. Long-term consumption of curcumin might improve the neurological outcomes of premature neonates delivered from dams suffering from infection/ inflammation. PMID: 30010156 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - July 18, 2018 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Effect of pre-surgery assessments on the prognosis of patients received extracranial-intracranial bypass surgery.
CONCLUSIONS: Our results suggest that a defined compensatory stage of cerebral ischemia might be useful for the prognosis of patients receiving EI-CI bypass surgery. PMID: 30010157 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - July 18, 2018 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Hypoglossal-facial nerve "side"-to-side neurorrhaphy for facial paralysis resulting from closed temporal bone fractures.
CONCLUSIONS: We concluded that the hypoglossal-facial nerve "side"-to-side neurorrhaphy can preserve the injured facial nerve and is suitable for treating significant incomplete facial paralysis resulting from closed temporal bone fractures, providing an evident beneficial effect. Moreover, this treatment may be performed earlier after the onset of facial paralysis in order to reduce the unfavorable changes to the injured facial nerve and atrophy of its target muscles due to long-term denervation and allow axonal regrowth in a rich supportive environment. PMID: 29889081 [PubMed - as supplied by publisher] (So...
Source: Restorative Neurology and Neuroscience - June 12, 2018 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Beyond the muscular involvement in non-dystrophic myotonias: The emerging role of neuromodulation.
CONCLUSION: our findings could suggest the deterioration of cortical sensory-motor plasticity in patients with NDMs as a trait of the disease. PMID: 29889082 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - June 12, 2018 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Effect of insulin-coated trimethyl chitosan nanoparticles on IGF-1, IGF-2, and apoptosis in the hippocampus of diabetic male rats.
CONCLUSIONS: The present study showed the efficacy of insulin coated nanoparticle in oral route manner that can be tested in Phase I- III clinical trials. However, a behavioral study could reveal the efficacy of insulin-loaded nanoparticles in the improvement of cognitive changes through the modulation of IGF-1 and IGF-2 levels in the hippocampus. PMID: 29889083 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - June 12, 2018 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Phenelzine, a small organic compound mimicking the functions of cell adhesion molecule L1, promotes functional recovery after mouse spinal cord injury.
CONCLUSIONS: This study provides new insights into the role of phenelzine in L1-mediated neural functions and modulation of inflammation. The combined results raise hopes that phenelzine may develop into a therapeutic agent for nervous system injuries. PMID: 29889084 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - June 12, 2018 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

T-cell infiltration into the perilesional cortex is long-lasting and associates with poor somatomotor recovery after experimental traumatic brain injury.
Authors: Ndode-Ekane XE, Matthiesen L, Bañuelos-Cabrera I, Palminha CAP, Pitkänen A Abstract BACKGROUND: T-lymphocyte (T-cell) invasion into the brain parenchyma is a major consequence of traumatic brain injury (TBI). However, the role of T-cells in the post-TBI functional outcome and secondary inflammatory processes is unknown. We explored the dynamics of T-cell infiltration into the cortex after TBI to establish whether the infiltration relates to post-injury functional impairment/recovery and progression of the secondary injury. METHOD: TBI was induced in rats by lateral fluid-percussion injury, ...
Source: Restorative Neurology and Neuroscience - June 12, 2018 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

A feasibility study of combined intermittent theta burst stimulation and modified constraint-induced aphasia therapy in chronic post-stroke aphasia.
CONCLUSION: This study shows feasibility and safety for combining behavioral and neurostimulation interventions for chronic post-stroke aphasia. Observed changes in linguistic measures were relatively small. However, they were statistically significant and associated with parallel changes observed in the neuroimaging. Our findings support further development and testing of the combined mCIAT and iTBS protocol and comparisons to either CIAT/mCIAT or iTBS applied alone for the treatment of post-stroke aphasia. PMID: 29889086 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - June 12, 2018 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research