Effects of insole on the less affected side during execution of treadmill walking training on gait ability in chronic stroke patients: A preliminary study.
CONCLUSIONS: ILTW, more than NTW, may improve walking ability in people with chronic stroke as it increases the weight-support ratio by adjusting the shoe height of the unaffected side using an insole. PMID: 33044203 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - October 13, 2020 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Improving motion detection via anodal transcranial direct current stimulation.
CONCLUSIONS: The present study suggests that tDCS may be used under appropriate stimulus conditions (low SNR and high dot numerosity) to boost the global motion processing efficiency, and may be useful to empower clinical protocols to treat visual deficits. PMID: 33016896 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - October 6, 2020 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Visual recovery following optic nerve crush in male and female wild-type and TRIF-deficient mice.
CONCLUSIONS: Our study showed that the TRIF pathway is involved in post-ONC inflammatory response and gliosis and that deletion of TRIF induces better RGC survival and regeneration and better functional recovery in mice. Our results suggest the TRIF pathway as a potential therapeutic target for reducing the inflammatory damage caused by nervous system injury. PMID: 32986632 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - September 30, 2020 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

The beneficial effect of vanillin on 6-hydroxydopamine rat model of Parkinson's disease.
CONCLUSIONS: Vanillin seems to offer protective properties against 6-OHDA lesion via preserving striatal dopamine levels. PMID: 32986633 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - September 30, 2020 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Protective role of protocatechuic acid in sevoflurane-induced neuron apoptosis, inflammation and oxidative stress in mice.
CONCLUSIONS: Our findings imply that apoptosis, inflammation, and oxidative stress in the hippocampal region of neonatal mouse brain were significantly reduced by pre-treatment with PCA before sevoflurane exposure. Therefore, suggesting a role for PCA as a novel therapeutic agent in the treatment of sevoflurane anesthesia-induced neurobehavioral dysfunction. PMID: 32986634 [PubMed - in process] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - September 30, 2020 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Prestroke statin use enhances collateralization in acute ischemic stroke patients.
CONCLUSIONS: Our findings suggest that prestroke statin use was associated with good leptomeningeal collaterals and clinical outcomes in acute ischemic stroke (AIS) patients presenting with occlusion of the middle cerebral artery. However, clinical studies should be conducted to verify this claim. PMID: 32925118 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - September 16, 2020 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Sensor-based technology for upper limb rehabilitation in subjects with multiple sclerosis: A randomized controlled trial.
CONCLUSIONS: Proposed training provides an intensive and functional-oriented rehabilitation that objectively evaluates achieved progress through exercises. Therefore, it can represent a good complementary strategy for hand rehabilitation in MS patients. PMID: 32925119 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - September 16, 2020 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Effect of platelet count on long-term prognosis of cerebral infarction.
This study aimed to analyze the correlation between platelet (PLT) count and the modified Rankin scale (mRS) in patients with cerebral infarction (CI) at the later stage of rehabilitation, which can be used to guide the secondary prevention strategy of CI. METHODS: A total of 180 CI patients were divided into three groups according to PLT count: low PLT group (226×109/L). The mRS was evaluated after three months and one year, respectively, and the difference in long-term prognosis between groups was analyzed. The mRS is an ordered scale coded from 0 (no symptoms at all) through 5 (severe disability) 6 (death). ...
Source: Restorative Neurology and Neuroscience - August 26, 2020 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Special Section: Low Vision: Rescue, Regeneration, Restoration and Rehabilitation, Guest Editors: Andrea Antal and Bernhard Sabel.
Authors: PMID: 32831208 [PubMed - in process] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - August 26, 2020 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Regular Section.
Authors: PMID: 32831209 [PubMed - in process] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - August 26, 2020 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Changes in eye movement parameters in the presence of an artificial central scotoma.
CONCLUSIONS: These findings suggest that the presence of an artificial central scotoma combined with a challenging discrimination task induces both changes in saccade planning mechanisms, resulting in a new eccentric-target alignment, and improvements in eccentric visual functions. This demonstrates the potential of this research paradigm to understand and potentially improve visual function in patients with central vision loss. PMID: 32675431 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - July 18, 2020 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Combining neurofeedback with source estimation: Evaluation of an sLORETA neurofeedback protocol for chronic tinnitus treatment.
CONCLUSIONS: Our study shows that a tomographic alpha/delta protocol should be considered a promising addition to tinnitus treatment but that more individually specific neurofeedback protocols should be developed. PMID: 32675432 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - July 18, 2020 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

A double-blind, randomized, controlled study of two dose strengths of dalfampridine extended release on walking deficits in ischemic stroke.
CONCLUSIONS: D-ER at either a 7.5 mg or 10 mg dose did not significantly increase performance on the 2 MinWT in stroke survivors with gait impairment, although this study was terminated early before full enrollment. (Clinical Trial # NCT02271217). PMID: 32651338 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - July 13, 2020 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

AhR and IDO1 in pathogenesis of Covid-19 and the "Systemic AhR Activation Syndrome" Translational review and therapeutic perspectives.
AhR and IDO1 in pathogenesis of Covid-19 and the "Systemic AhR Activation Syndrome" Translational review and therapeutic perspectives. Restor Neurol Neurosci. 2020 Jun 24;: Authors: Turski WA, Wnorowski A, Turski GN, Turski CA, Turski L Abstract Covid-19 is the acute illness caused by SARS-CoV-2 with initial clinical symptoms such as cough, fever, malaise, headache, and anosmia. After entry into cells, corona viruses (CoV) activate aryl hydrocarbon receptors (AhRs) by an indoleamine 2,3-dioxygenase (IDO1)-independent mechanism, bypassing the IDO1-kynurenine-AhR pathway. The IDO1-kynurenine-Ah...
Source: Restorative Neurology and Neuroscience - July 1, 2020 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Regulation of gene expression after combined scalp acupuncture and transcranial magnetic stimulation in middle cerebral artery occlusion mice.
CONCLUSIONS: Each stimulation method showed different patterns with neurotrophin signaling pathway including NFκB, SHC, p90RSK, and CHK. These can be used in further mechanistic studies about gene expression related to neurorecovery. PMID: 32444581 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - May 25, 2020 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Astragaloside IV regulates the HIF/VEGF/Notch signaling pathway through miRNA-210 to promote angiogenesis after ischemic stroke.
CONCLUSIONS: AS-IV promotes cerebral protection following angiogenesis and ischemic brain injury. The specific mechanism was activating the HIF/VEGF/Notch signaling pathway via miRNA-210. PMID: 32417803 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - May 19, 2020 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Effects of robot-assisted gait training combined with virtual reality on motor and cognitive functions in patients with multiple sclerosis: A pilot, single-blind, randomized controlled trial.
CONCLUSIONS: Both training lead to positive influenced on executive functions. However larger positive effects on gait ability were noted after robot-assisted gait training engendered by virtual reality with multiple sclerosis. Robot-assisted gait training provides a therapeutic alternative and motivational of traditional motor rehabilitation. PMID: 32333564 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - April 26, 2020 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Improvement of motor performance in children with cerebral palsy treated with exoskeleton robotic training: A retrospective explorative analysis.
Authors: Digiacomo F, Tamburin S, Tebaldi S, Pezzani M, Tagliafierro M, Casale R, Bartolo M PMID: 32333565 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - April 26, 2020 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Mesenchymal stem cell surgery, rescue and regeneration in retinitis pigmentosa: Clinical and rehabilitative prognostic aspects.
CONCLUSIONS: Previous studies have described the role of LRRT in slowing down retinal degenerative diseases. Consequently, this surgical procedure could improve the clinical and rehabilitative prognostic parameters in RP patients. On the other hand, further clinical research and studies with longer follow-up will be needed to evaluate its efficacy. PMID: 32310198 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - April 22, 2020 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Distinct neurotoxic effects of select local anesthetics on facial nerve injury and recovery.
CONCLUSIONS: Our data demonstrate that some local anesthetics, but not all, exacerbate motoneuron death and delay functional recovery after a peripheral nerve injury. These and future results may lead to clinical strategies that decrease the risk of neural deficit following peripheral nerve blocks with local anesthetics. PMID: 32310199 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - April 22, 2020 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Effects of EMG-triggered FES during trunk pattern in PNF on balance and gait performance in persons with stroke.
CONCLUSIONS: The results of this study showed that PNF trunk pattern affected the trunk control for stroke patients, and increased trunk control ability was effective in improving balance and walking. In addition, it was found that the EMG-triggered FES applied to the PNF trunk pattern affected the trunk control. PMID: 32250337 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - April 8, 2020 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Standalone cooperation-free OKN-based low vision contrast sensitivity estimation in VR - a pilot study.
CONCLUSIONS: The developed OKN-based sensitivity test represents a reliable proof of concept for technology readiness of virtual reality-based screening tools of visual function in practice, specifically in patients with difficulties to report perception verbally, or under conditions, where no experienced examiner is present. PMID: 32200360 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - March 23, 2020 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Non-immersive Virtual Reality Rehabilitation Applied to a Task-oriented Approach for Stroke Patients: A  Randomized Controlled Trial.
CONCLUSIONS: This study suggests that virtual upper extremity training using the RAPAEL smart glove has reasonable and beneficial effects on upper extremity and cognitive function for chronic hemiparetic stroke survivors. PMID: 32176674 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - March 18, 2020 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Efficacy of coupling intermittent theta-burst stimulation and 1  Hz repetitive transcranial magnetic stimulation to enhance upper limb motor recovery in subacute stroke patients: A randomized controlled trial.
CONCLUSIONS: The combining of 1 Hz rTMS and iTBS protocol in the present study is tolerable and more beneficial for motor improvement than the single use of 1 Hz rTMS in patients with subacute stroke. PMID: 32039879 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - February 12, 2020 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Hyperbaric oxygen therapy improves neurocognitive functions of post-stroke patients - a retrospective analysis.
Authors: Hadanny A, Rittblat M, Bitterman M, May-Raz I, Suzin G, Boussi-Gross R, Zemel Y, Bechor Y, Catalogna M, Efrati S Abstract BACKGROUND: Previous studies have shown that hyperbaric oxygen therapy (HBOT) can improve the motor functions and memory of post-stroke patients in the chronic stage. OBJECTIVE: The aim of this study is to evaluate the effects of HBOT on overall cognitive functions of post-stroke patients in the chronic stage. The nature, type and location of the stroke were investigated as possible modifiers. METHODS: A retrospective analysis was conducted on patients who were treated with HBOT...
Source: Restorative Neurology and Neuroscience - January 29, 2020 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Dissociations between perception and awareness in hemianopia.
Authors: Chokron S, Dubourg L, Garric C, Martinelli F, Perez C Abstract The most common visual defect to follow a lesion of the retrochiasmal pathways is homonymous hemianopia (HH), whereby patients are blind to the contralesional visual field of each eye. Homonymous hemianopia has been studied in terms of its deleterious consequences on perceptual, cognitive and motor tasks as well as because it represents an interesting model of vision loss after a unilateral lesion of the occipital lobe. From a behavioral perspective, in addition to exhibiting a severe deficit in their contralesional visual field, HH patients ca...
Source: Restorative Neurology and Neuroscience - January 15, 2020 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Translating concepts of neural repair after stroke: Structural and functional targets for recovery.
Authors: Regenhardt RW, Takase H, Lo EH, Lin DJ Abstract Stroke is among the commonest causes of adult disability worldwide, and its disease burden is shifting towards that of a long-term condition. Therefore, the development of approaches to enhance recovery and augment neural repair after stroke will be critical. Recovery after stroke involves complex interrelated systems of neural repair. There are changes in both structure (at the molecular, cellular, and tissue levels) and function (in terms of excitability, cortical maps, and networks) that occur spontaneously within the brain. Several approaches to augment n...
Source: Restorative Neurology and Neuroscience - January 15, 2020 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Non-invasive current stimulation in vision recovery: a review of the literature.
CONCLUSIONS: Study's findings suggest conclusive evidence for rtACS treatment. For other protocols results are promising but not conclusive since the examined studies assessed different stimulation parameters and endpoints. A comparison of the effects of different combinations of these variables still lacks in the literature. Further studies are needed to optimize existing protocols and determine if different protocols are needed for different diseases. PMID: 31884495 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - January 1, 2020 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Color vision in sight recovery individuals.
CONCLUSIONS: Our results support the view that, development of visual functions such as color discrimination and color arrangement does not depend on typical visual experience during a sensitive phase in early childhood. PMID: 31839614 [PubMed - in process] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - December 17, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Cholinergic potentiation of visual perception and vision restoration in rodents and humans.
CONCLUSIONS: Potential therapeutic outcomes ought to facilitate vision restoration using commercially available cholinergic agents combined with visual stimulation in order to prevent irreversible vision loss in patients. This approach has the potential to help a large population of visually impaired individuals. PMID: 31839615 [PubMed - in process] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - December 17, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Lab review: Molecular dissection of the signal transduction pathways associated with PTEN deletion-induced optic nerve regeneration.
CONCLUSIONS: A key permissive signal from an unidentified AKT-independent pathway is required for stimulating the neuron-intrinsic growth machinery. Future studies into this complex neuron-intrinsic balancing mechanism involving necessary and permissive signals for axon regeneration is likely to lead to safe and effective regenerative strategies for CNS repair. PMID: 31839616 [PubMed - in process] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - December 17, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Low vision: Rescue, regeneration, restoration and rehabilitation.
Authors: Antal A, Sabel B PMID: 31839617 [PubMed - in process] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - December 17, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Cell transplantation of retinal ganglion cells derived from hESCs.
Authors: Zhang X, Tenerelli K, Wu S, Xia X, Yokota S, Sun C, Galvao J, Venugopalan P, Li C, Madaan A, Goldberg JL, Chang KC Abstract BACKGROUND: Glaucoma, the number one cause of irreversible blindness, is characterized by the loss of retinal ganglion cells (RGCs), which do not regenerate in humans or mammals after cell death. Cell transplantation provides an opportunity to restore vision in glaucoma, or other optic neuropathies. Since transplanting primary RGCs from deceased donor tissues may not be feasible, stem cell-derived RGCs could provide a plausible alternative source of donor cells for transplant. OBJ...
Source: Restorative Neurology and Neuroscience - December 10, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

The effect of repetitive transcranial magnetic stimulation on cognitive impairment in Parkinson's disease with dementia: Pilot study.
CONCLUSIONS: rTMS over M1 is useful for motor function and may have a small positive effect on cognition. However, better approaches for the latter are necessary, may be require multisite rTMS to target both motor and frontal cortical region. PMID: 31815705 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - December 10, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

What causes dyslexia? Identifying the causes of dyslexia and effective compensatory therapy.
ConclusionsThe causes of dyslexia can be revealed by a dual-intervention approach consisting of a pseudoword experiment and learning a compensatory reading strategy. Reading performance improves immediately if the identified causes of dyslexia are compensated by an appropriate reading therapy. PMID: 31796709 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - December 6, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Exercise and retinal health.
Authors: Li HY, Rong SS, Hong X, Guo R, Yang FZ, Liang YY, Li A, So KF Abstract  Many ocular diseases (such as glaucoma, diabetic retinopathy, age-related macular degeneration, and traumatic eye injuries) can result in the degeneration of retinal cells and the subsequent loss of vision. Some kinds of treatments, such as drugs, stem cell transplantation and surgery are reported to be effective in certain patients. However, no confirmatively effective, convenient and low-price intervention has been available so far. Physical exercise has been reported to exert neuroprotective effects on several neurodegenerative...
Source: Restorative Neurology and Neuroscience - December 6, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Multisensory and spatial processes in sensory substitution.
Authors: Auvray M Abstract Sensory substitution devices aim at compensating sensory deficits by converting stimuli coming from a deficient sensory modality (e.g., vision) into stimuli accessible through another modality (e.g., touch or audition). Studies conducted with these devices revealed the central nervous system to be very plastic. Various laboratories have conducted studies investigating such plasticity by means of behavioural and brain-imaging techniques. At the ISIR Laboratory, we focused on the factors underlying the learning of sensory substitution devices, their adequacy to the target population, and we...
Source: Restorative Neurology and Neuroscience - December 6, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Effect of dry-electrode-based transcranial direct current stimulation on chronic low back pain and low back muscle activities: A double-blind sham-controlled study.
CONCLUSIONS: Dry-electrode-based transcranial direct current stimulation can lower pain perception in patients with chronic low back pain. The analgesic mechanism can affect the top-down modulation pathway of pain. PMID: 31683491 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - November 7, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Temporal gene expression changes after acute and delayed ventral root avulsion-reimplantation.
CONCLUSIONS: Our study reveal that genetic profiling after this kind of injury is possible, that specific and distinct expression patterns can be found with early reimplantation being favourable over late and that regenerative activity in this kind of injury bears hallmark typical for peripheral nerve regeneration. These findings can be useful in elucidating specific genetic expression typical for successful nerve regeneration, hopefully not only in this specific model but in the nervous system in general. PMID: 31683492 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - November 7, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Bilateral motor priming for post stroke upper extremity hemiparesis: A randomized pilot study.
CONCLUSIONS: Both groups improved in the CAHAI. There was a significant between-group difference in the secondary outcome measure (FMUE) where the bilateral priming group had an average increase of 10 points from pre-intervention to follow up. PMID: 31609714 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - October 16, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Optic nerve regeneration: A long view.
Authors: Yin Y, De Lima S, Gilbert HY, Hanovice NJ, Peterson SL, Sand R, Sergeeva EG, Wong KA, Xie L, Benowitz LI Abstract The optic nerve conveys information about the outside world from the retina to multiple subcortical relay centers. Until recently, the optic nerve was widely believed to be incapable of re-growing if injured, with dire consequences for victims of traumatic, ischemic, or neurodegenerative diseases of this pathway. Over the past 10-20 years, research from our lab and others has made considerable progress in defining factors that normally suppress axon regeneration and the ability of retinal gangl...
Source: Restorative Neurology and Neuroscience - October 16, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Dorsal root ganglion axons facilitate and guide cortical neural outgrowth: In vitro modeling of spinal cord injury axonal regeneration.
CONCLUSIONS: Our findings support the use of DRG axons to facilitate the growth of cortical neurons in a process of axon-facilitated axon regeneration. We believe these results could have implications for the treatment of SCI. PMID: 31594262 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - October 10, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Motor impairments in transient ischemic attack increase the odds of a positive diffusion-weighted imaging: A meta-analysis.
CONCLUSIONS: The current meta-analysis provides cumulative evidence from 6710 individuals with TIA that the presence of motor symptoms increases the odds of a positive DWI by two-folds. These findings transform the clinical perception into evidence-based knowledge that motor impairments elevate the risk for brain tissue damage. Unilateral motor impairments in a cerebrovascular event should increase a physician's suspicion of detecting brain infarctions. These findings may influence the clinical management of TIA by generating faster response to motor impairments in TIA and accelerating referral to specialized stroke clinic...
Source: Restorative Neurology and Neuroscience - October 10, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Mirror feedback assisted recovery from hemiparesis following stroke In Reply to Morkisch et al.: How to perform mirror therapy after stroke? Evidence from a meta-analysis.
Authors: Ramachandran VS, Rogers-Ramachandran D Abstract 1 out of 6 people worldwide will have suffered a stroke in their lifetime, 1/3rd of whom will die. Of the 2/3rd who survive, half will be permanently disabled (World Stroke Organization). Given these alarming statistics, it's not surprising that tremendous of amounts of time, resources and funding have been devoted towards research into stroke rehab. In view of this, simple, easy-to-implement procedures are highly sought after. One such procedure is the use of visual feedback conveyed by a mirror, which seems to reactivate some dormant pathways in patients wh...
Source: Restorative Neurology and Neuroscience - October 10, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Transfer of reactive balance adaptation from stance-slip perturbation to stance-trip perturbation in chronic stroke survivors.
Authors: Dusane S, Wang E, Bhatt T Abstract BACKGROUND: Chronic stroke survivors demonstrate the potential to acquire reactive adaptations to external perturbations. However, such adaptations in postural stability and compensatory stepping responses are perturbation-type specific and the ability to generalize such adaptation to an opposing perturbation has not been studied. OBJECTIVE: The study aimed to examine whether improved reactive balance control acquired through prior slip-perturbation training would positively transfer to, or interfere with, the reactive response to an unexpected novel trip. METHODS...
Source: Restorative Neurology and Neuroscience - September 30, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Enhancing mirror visual feedback with intermittent theta burst stimulation in healthy adults.
CONCLUSIONS: iTBS appears to prime subjects' brain to be more receptive to MVF. PMID: 31424421 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - August 21, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

How to perform mirror therapy after stroke? Evidence from a meta-analysis.
CONCLUSIONS: The results of this analysis suggest that the effects on both motor function and impairment of the affected upper limb depend on the therapy protocol. They furthermore indicate that a large mirror, unilateral movement execution and exercises without objects may be parameters that enhance the effects of MT for improving motor function after stroke. PMID: 31424422 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - August 21, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Analgesia-enhancing effects of repetitive transcranial magnetic stimulation on neuropathic pain after spinal cord injury:An fNIRS study.
CONCLUSIONS: The findings of this preliminary study with a small patient sample suggest that the analgesia-enhancing effects of high-frequency rTMS might be related with the amelioration of M1 and PMC hypersensitivity, shedding light upon the clinical treatment of SCI-related neuropathic pain. PMID: 31381538 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - August 7, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

The addition of the MEP amplitude of finger extension muscles to clinical predictors of hand function after stroke; a prospective cohort study.
CONCLUSIONS: Our study demonstrates no additional value of motor evoked potential amplitude of the affected EDC muscle to the clinical test of finger extension, the latter being more strongly related to FMA_UE26. PMID: 31322583 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - July 21, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Early recovery of neuronal functioning in the sensory cortex after nerve reconstruction surgery.
CONCLUSIONS: Robust neuronal responses to sensory stimulation even when only sparse sensory inputs are available in the early recovery phase. During this phase, aberrant reinnervation induced disorganized whisker tuning, a finding that might be account for the hypoesthesia and paresthesia during early recovery after nerve reconstruction. PMID: 31322584 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - July 21, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research