A low-cost system for coil tracking during transcranial magnetic stimulation.
Authors: Washabaugh EP, Krishnan C Abstract PURPOSE: Accurate coil placement over a target area is critical during transcranial magnetic stimulation (TMS), as small deviations can alter testing outcomes. Accordingly, frameless stereotaxic systems (FSS) are recommended for reliable coil placement during TMS applications. However, FSS is not practical due to the cost associated with procuring such systems. Therefore, the purpose of this study was to develop a low-cost TMS coil tracking approach using simple webcams and an image processing algorithm in LabVIEW Vision Assistant. METHODS: A system was created using ...
Source: Restorative Neurology and Neuroscience - March 1, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Pre-conditioning with transcranial low-level light therapy reduces neuroinflammation and protects blood-brain barrier after focal cerebral ischemia in mice.
CONCLUSIONS: Non-invasive intervention of LLLT in ischemic brain injury may provide a significant functional benefit with an underlying mechanism possibly being suppression of neuroinflammation and reduction of BBB disruption. PMID: 26889965 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - February 20, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

The dynamic motor imagery of locomotion is task-dependent in patients with stroke.
This study was aimed to investigate time and spatial parameters of dMI with actual locomotion in people with stroke. METHODS: Twelve patients (stroke group, SG) were compared with twelve healthy elderly (elderly group, EG) and twenty young adults (young group, YG). Subjects performed mental representations of different walking (forward, FW; lateral, LW, backward, BW), accompanied or not by movements imitating walking (dMI and static MI, sMI). Then, they performed actual locomotion (AL). Outcome measures were related to the time and number of steps spent for completing the tasks for all the given locomotor conditions. ...
Source: Restorative Neurology and Neuroscience - February 20, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Ultrasonic vocalization in murine experimental stroke: A mechanistic model of aphasia.
CONCLUSION: These findings set a foundation for further studies of mechanisms and novel treatment strategies for post-stroke vocalization impairments. PMID: 26889967 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - February 20, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

L1.2, the zebrafish paralog of L1.1 and ortholog of the mammalian cell adhesion molecule L1 contributes to spinal cord regeneration in adult zebrafish.
CONCLUSIONS: Our findings support the speculation that paralogs of duplicated genes can exert similar functions and may thus represent an advantage over other species that do not carry duplicated genes. PMID: 26889968 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - February 20, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Grasping objects by former amputees: The visuo-motor control of allografted hands.
CONCLUSION: Hand allotransplantation can offer recipients a good recovery of the visuo-motor control of prehension, with slight impairments likely attributable to peripheral neuro-orthopedic limitations. PMID: 26890093 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - February 20, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Neuronavigated left temporal continuous theta burst stimulation in chronic tinnitus.
CONCLUSIONS: In our study, verum cTBS was not superior to sham which highlights the persistent need for improving non-invasive brain stimulation techniques for the treatment of tinnitus. Future research should focus on the transfer of positive single session effects to daily treatment trials. PMID: 26890094 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - February 20, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Effects of transcranial random noise stimulation (tRNS) on affect, pain and attention in multiple sclerosis.
CONCLUSIONS: This study suggests the role of tRNS in pain modulation, which could have been more evident with longer stimulation protocols. PMID: 26890095 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - February 20, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Evidence for reading improvement following tDCS treatment in children and adolescents with Dyslexia.
CONCLUSIONS: The study shows preliminary evidence of tDCS feasibility and efficacy in improving non-words and low frequency words reading of children and adolescents with dyslexia and it opens new rehabilitative perspectives for the remediation of dyslexia. PMID: 26890096 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - February 20, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Interactive virtual feedback improves gait motor imagery after spinal cord injury:An exploratory study.
CONCLUSIONS: This exploratory study showed that interactive virtual walking was feasible and facilitated motor imagery performance. The response to motor imagery interventions after SCI might be improved by using interactive virtual feedback. PMID: 26890097 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - February 20, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Kinematic measures for upper limb motor assessment during robot-mediated training in patients with severe sub-acute stroke.
Authors: Duret C, Courtial O, Grosmaire AG Abstract PURPOSE: Kinematic assessments are increasingly used as motor outcome measures during upper limb robot-assisted training, in addition to clinical scales. However, their relevance has not been evaluated much. METHODS: Thirty-eight patients with severe sub-acute stroke (age 56 ± 17 [19-87] years; time since stroke, 55 ± 22 days) carried out 16 sessions (average 3/week, 35 ± 15 days) of upper limb robot-assisted training combined with standard therapy. Pre/post motor performance was evaluated using the Fugl-Meyer Assessment scale, Motor Statu...
Source: Restorative Neurology and Neuroscience - February 20, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Neuroprotection and anti-seizure effects of levetiracetam in a rat model of penetrating ballistic-like brain injury.
CONCLUSIONS: These findings support the dual anti- seizure and neuroprotective role of LEV, but more importantly identify the importance of an extended dosing protocol which was specific to the therapeutic targets studied. PMID: 26890099 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - February 20, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Vascular insufficiency, not inflammation, contributes to chronic gliosis in a rat CNS transplantation model.
CONCLUSION: These data suggest that ischemic conditions and blood brain barrier damage can be a primary mechanism that initiates chronic gliosis and associated inflammatory changes in central nervous system tissue. PMID: 26890100 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - February 20, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

The effect of sleep on motor learning in the aging and stroke population - a systematic review.
Authors: Backhaus W, Kempe S, Hummel FC Abstract There is extensive evidence for positive effects of sleep on motor learning in young individuals; however, the effects of sleep on motor learning in people with stroke and in healthy older individuals are not well understood. The aim of this systematic review was to quantify the association between sleep and procedural memory performance - a marker for motor learning - in healthy older people and people with stroke. After searches in PubMed, Medline and Embase fourteen studies, including 44 subjects after stroke and 339 healthy older participants were included. Overa...
Source: Restorative Neurology and Neuroscience - February 4, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Effects of repetitive transcranial magnetic stimulation on freezing of gait in patients with Parkinsonism.
CONCLUSIONS: Use of 10 Hz rTMS on the M1-LL and DLPFC is therapeutically effective for FOG in patients with parkinsonism. PMID: 25079979 [PubMed - indexed for MEDLINE] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - January 25, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Combining enriched environment and induced pluripotent stem cell therapy results in improved cognitive and motor function following traumatic brain injury.
CONCLUSIONS: Overall, EE or iPSC therapy improved cognition and motor performance, however, full cognitive restoration was seen only with the EE/iPSC treatment. These data suggest that EE/iPSC therapy should be explored as a potential, clinically relevant, treatment for TBI. PMID: 25079980 [PubMed - indexed for MEDLINE] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - January 25, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Post-operative environmental enrichment improves spatial and motor deficits but may not ameliorate anxiety- or depression-like symptoms in rats following traumatic brain injury.
CONCLUSIONS: Additional therapeutic approaches paired with EE may be necessary to address all functional changes post-TBI. Additionally, no single behavioral assessment appears to clearly identify symptoms of ANX or DEP in rats following TBI, however utilizing multiple tests can be potentially confounding. PMID: 25079981 [PubMed - indexed for MEDLINE] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - January 25, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Altered expression of myelin-associated inhibitors and their receptors after traumatic brain injury in the mouse.
CONCLUSION: These results suggest that early dynamic changes in MAI gene expression occur following TBI in the mouse, particularly in the hippocampus, which may play an inhibitory role for post-injury regeneration and plasticity. PMID: 25079982 [PubMed - indexed for MEDLINE] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - January 25, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Changes in the gray matter volume during compensation after vestibular neuritis: a longitudinal VBM study.
CONCLUSIONS: The structural layout of vestibular compensation suggests that memory and motor planning are closely related to this process. Vision seems to be a major source of functional substitution, as has been previously demonstrated. This study, however, is the first longitudinal analysis of brain structural changes associated with recovery of balance following unilateral VN. PMID: 25096973 [PubMed - indexed for MEDLINE] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - January 25, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Are cognitive interventions for multiple sclerosis effective and feasible?
CONCLUSIONS: This is the first meta-analysis assessing the effects of cognitive intervention in MS including only RCTs with comparable conditions. Research regarding efficacy, cost-effectiveness and feasibility is still in its infancy. Caution is advised when interpreting these results due to the small number of RCTs meeting the inclusion criteria. Considering the costs of disease, good completion and adherence rates of this approach, further research is warranted. Recommendations concerning improved research practices in the field are presented as well. PMID: 25096974 [PubMed - indexed for MEDLINE] (Source: Restorativ...
Source: Restorative Neurology and Neuroscience - January 25, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Age at stroke determines post-stroke language lateralization.
Authors: Szaflarski JP, Allendorfer JB, Byars AW, Vannest J, Dietz A, Hernando KA, Holland SK Abstract PURPOSE: To determine how age at the time of left middle cerebral artery stroke affects language lateralization in a combined sample of subjects with perinatal, childhood, and adult stroke. METHODS: 19 participants who had perinatal stroke (
Source: Restorative Neurology and Neuroscience - January 25, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Motor recovery from constraint induced movement therapy is not constrained by extent of tissue damage following stroke.
CONCLUSIONS: In sum, the extent of brain tissue damage of any type examined here poorly predicted motor function and response to rehabilitation in chronic stroke. PMID: 25189180 [PubMed - indexed for MEDLINE] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - January 25, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Anodal transcranial direct current stimulation over the dorsolateral prefrontal cortex improves anorexia nervosa: A pilot study.
CONCLUSIONS: These findings suggest that tDCS has potential as an adjuvant treatment for AN and deserves further study. PMID: 25189181 [PubMed - indexed for MEDLINE] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - January 25, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

The "EyeCane", a new electronic travel aid for the blind: Technology, behavior & swift learning.
CONCLUSIONS: These results demonstrate the EyeCane's potential for mobility rehabilitation. The short training time is especially important since available mobility training resources are limited, not always available, and can be quite expensive and/or entail long waiting periods. PMID: 25201814 [PubMed - indexed for MEDLINE] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - January 25, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Inhibitory repetitive transcranial magnetic stimulation of the contralesional premotor and primary motor cortices facilitate poststroke motor recovery.
CONCLUSIONS: In patients with chronic stroke, the cPMd can fulfill a role similar to that of the cM1 in interhemispheric imbalance, which can be ameliorated by applying inhibitory rTMS to achieve substantial motor restoration. PMID: 25201815 [PubMed - indexed for MEDLINE] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - January 25, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Contingent capture of involuntary visual spatial attention does not differ between normally hearing children and proficient cochlear implant users.
CONCLUSION: These results suggest that proficient cochlear implant users demonstrate normal capture of visuospatial attention by stimuli that match top-down control settings. PMID: 25201816 [PubMed - indexed for MEDLINE] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - January 25, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

A case of post-traumatic minimally conscious state reversed by midazolam: Clinical aspects and neurophysiological correlates.
CONCLUSIONS: We advance some hypotheses about certain aspects of the recovery from the MCS both in terms of anatomo-functional correlations and functional brain systems and we make inferences about the role that some kind of 'catatonic' symptoms might play in determining and/or maintaining this peculiar clinical state. PMID: 25281612 [PubMed - indexed for MEDLINE] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - January 25, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Selegiline promotes NOTCH-JAGGED signaling in astrocytes of the peri-infarct region and improves the functional integrity of the neurovascular unit in a rat model of focal ischemia.
CONCLUSION: Our results suggest that selegiline treatment enhances Notch-Jagged signaling in astrocytes, reduces peri-lesional edema and potentially helps preserve the capillary network following focal ischemia. PMID: 25361607 [PubMed - indexed for MEDLINE] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - January 25, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Evaluation of differences in brain neurophysiology and morphometry associated with hand function in individuals with chronic stroke.
CONCLUSIONS: RESULTS confirm and extend findings showing differences in brain structure and function after stroke. RESULTS suggested a structure-function relationship underlying interhemispheric connectivity in chronic stroke. The utility of combined TMS and MRI measures to predict motor function can be used in future investigations to aid identifying optimal biomarkers of stroke recovery to predict response to rehabilitation to maximize treatment outcomes. PMID: 25374346 [PubMed - indexed for MEDLINE] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - January 25, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Neural plasticity of voice processing: Evidence from event-related potentials in late-onset blind and sighted individuals.
CONCLUSION: In contrast to congenitally blind individuals, late blind individuals did not show an early Person Match effect in the time range of the N1, suggesting that crossmodal compensation is mediated by later processing steps rather than by changes at early perceptual levels. PMID: 25374347 [PubMed - indexed for MEDLINE] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - January 25, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Do all sub acute stroke patients benefit from robot-assisted therapy? A retrospective study.
CONCLUSION: High intensity robot-assisted training may be associated with motor improvement in subacute hemiparesis. More severely impaired patients may derive greater benefit from robot-assisted training; age, aphasia and neglect do not represent exclusion criteria. PMID: 25420902 [PubMed - indexed for MEDLINE] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - January 25, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Effects of pigment epithelium-derived factor on traumatic brain injury.
CONCLUSION: The present work indicates that PEDF acts as a multifunctional agent after TBI influencing cell death, inflammation and cell proliferation. PMID: 25420903 [PubMed - indexed for MEDLINE] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - January 25, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Altered top-down cognitive control and auditory processing in tinnitus: evidences from auditory and visual spatial stroop.
CONCLUSIONS: Tinnitus is associated both with modality-specific deficits along the auditory processing system and an impairment of cognitive control mechanisms that are involved both in vision and audition (i.e. that are supra-modal). We postulate that this deficit in the top-down cognitive control is a key-factor in the development and maintenance of tinnitus and may also explain some of the cognitive difficulties reported by tinnitus sufferers. PMID: 25420904 [PubMed - indexed for MEDLINE] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - January 25, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Functional recovery after experimental spinal cord compression and whole body vibration therapy requires a balanced revascularization of the injured site.
CONCLUSION: The results of this study provide for the first time evidence that intensive WBV-therapy leads to a significantly denser capillary network in the lesioned spinal cord. However, since this higher capillary density is not associated with improved functional recovery (possibly because it exceeded the balance necessary for functional improvements), optional treatments with lower intensity or less time of WBV-therapy should be tested. PMID: 25503507 [PubMed - indexed for MEDLINE] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - January 25, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Ipsilesional motor area size correlates with functional recovery after stroke: a 6-month follow-up longitudinal TMS motor mapping study.
CONCLUSION: The present data suggests the presence of a positive correlation between changes of the motor representation of the lesioned hemisphere and functional recovery after stroke. A possible interpretation is that rather (re-)activated corticomotor outputs are substrates of functional recovery after stroke than increased efficacy of residual, non-lesioned pathways. PMID: 25503508 [PubMed - indexed for MEDLINE] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - January 25, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Chronic spinal cord lesions respond positively to tranplants of mesenchymal stem cells.
CONCLUSION: We conclude that MSC-based cell therapy, even when applied during the chronic phase of SCI, leads to changes in a number of structural and functional parameters, all of which indicate improved recovery. PMID: 25537259 [PubMed - indexed for MEDLINE] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - January 25, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

L-dopa does not add to the success of high-intensity language training in aphasia.
CONCLUSION: High-intensity language training in chronic aphasia may take learning to a ceiling that precludes additive benefits from l-dopa. Effects of l-dopa on post-stroke recovery during less intense treatment in chronic aphasia remain to be evaluated. PMID: 25588456 [PubMed - indexed for MEDLINE] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - January 25, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Early hyaluronate injection improves quality of life but not neural recovery in unilateral vocal fold paralysis: an open-label randomized controlled study.
CONCLUSIONS: Early hyaluronate injection cannot improve nerve regeneration but can result in long-lasting improvements in patients' psychosocial well-being, thus highlighting the importance of early intervention for patients with UVFP. PMID: 25588457 [PubMed - indexed for MEDLINE] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - January 25, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Cortical inhibition and excitation by bilateral transcranial alternating current stimulation.
CONCLUSIONS: tACS targeting bilateral homologous cortical areas can induce online inhibition or excitation as a function of the current density. PMID: 25588458 [PubMed - indexed for MEDLINE] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - January 25, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

An ischemic stroke model of nonhuman primates for remote lesion studies: a behavioral and neuroimaging investigation.
CONCLUSIONS: MCAO or even sham operations might cause cerebral infarction in NHPs. Therefore, neurological assessment should be combined with MRI for screening candidate stroke models. Our model is suitable for studying secondary damage in remote regions, including the thalamus, hippocampus, and substantia nigra, after stroke. PMID: 25588459 [PubMed - indexed for MEDLINE] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - January 25, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Treatment with amnion-derived cellular cytokine solution (ACCS) induces persistent motor improvement and ameliorates neuroinflammation in a rat model of penetrating ballistic-like brain injury.
CONCLUSIONS: ACCS, as a treatment for TBI, showed promise with regard to functional (motor) recovery and demonstrated strong capability to modulate neuroinflammatory responses that may underline functional recovery. However, the majority of beneficial effects appear restricted to the i.c.v. route of ACCS delivery, which warrants future studies examining delivery routes (e.g. intranasal delivery) which are more clinically viable for the treatment of TBI. PMID: 25588460 [PubMed - indexed for MEDLINE] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - January 25, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Can transcranial direct current stimulation be useful in differentiating unresponsive wakefulness syndrome from minimally conscious state patients?
CONCLUSION: a-tDCS could be useful in identifying residual connectivity markers in clinically-defined UWS, who may lack of purposeful behavior as a result of a motor-output failure. PMID: 25588461 [PubMed - indexed for MEDLINE] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - January 25, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Caspase-3 inhibitor Z-DEVD-FMK enhances retinal ganglion cell survival and vision restoration after rabbit traumatic optic nerve injury.
CONCLUSIONS: The caspase-3 inhibitor Z-DEVD-FMK is neuroprotective by inhibiting RGCs apoptosis when injected 30 min after optic nerve damage and significantly promotes restoration of vision. A controlled clinical trial is now needed to evaluate the efficacy and safety of Z-DEVD-FMK in humans. PMID: 25588462 [PubMed - indexed for MEDLINE] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - January 25, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Quercetin ameliorates hypobaric hypoxia-induced memory impairment through mitochondrial and neuron function adaptation via the PGC-1α pathway.
CONCLUSIONS: The results suggest quercetin has prophylactic potential for amelioration of HH-induced memory impairment, which is associated with the mitochondrial and neuronal adaptation in hippocampus. PMID: 25588463 [PubMed - indexed for MEDLINE] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - January 25, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Prefrontal cortex as a compensatory network in ataxic gait: a correlation study between cortical activity and gait parameters.
CONCLUSIONS: Our results suggest that PFC activity is linked to gait compensatory mechanisms more than to the variability of the joint kinematic parameters caused by a defective cerebellar control. PMID: 25588464 [PubMed - indexed for MEDLINE] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - January 25, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Neuroprotective effects of collagen matrix in rats after traumatic brain injury.
Authors: Shin SS, Grandhi R, Henchir J, Yan HQ, Badylak SF, Dixon CE Abstract PURPOSE: In previous studies, collagen based matrices have been implanted into the site of lesion in different models of brain injury. We hypothesized that semisynthetic collagen matrix can have neuroprotective function in the setting of traumatic brain injury. METHODS: Rats were subjected to sham injury or controlled cortical impact. They either received extracellular matrix graft (DuraGen) over the injury site or did not receive any graft and underwent beam balance/beam walking test at post injury days 1-5 and Morris water maze at p...
Source: Restorative Neurology and Neuroscience - January 25, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Long-term behavioral deficits and recovery after transient ischemia in middle-aged rats: Effects of behavioral testing.
CONCLUSIONS: Deficits persist for at least 8 weeks after tMCAO. The greater spontaneous recovery seen in the RLT groups suggest that repeated testing did reduce the severity of these stroke-induced impairments. These findings have implications for designing future studies of agents to induce long-term functional recovery following stroke. PMID: 25624424 [PubMed - in process] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - January 25, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

A systematic review of transcranial electrical stimulation combined with cognitive training.
CONCLUSIONS: tES + CT enhances performance on CT tasks across a range of cognitive functions. Preliminary evidence suggests that tES may also increase transfer effects to non-trained tasks in some domains. Recommendations for future studies are provided. PMID: 25624425 [PubMed - in process] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - January 25, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Structural remodeling of white matter in the contralesional hemisphere is correlated with early motor recovery in patients with subcortical infarction.
This study aimed to identify brain areas with white matter changes that contribute to motor recovery of affected limbs during acute to sub-acute phases of subcortical infarction. METHODS: Diffusion tensor imaging was performed 1, 4, and 12 weeks after stroke onset in 18 patients with acute subcortical infarct, and in 18 age- and risk factor-matched controls. Fugl-Meyer scale was used to assess levels of motor impairment, and Statistical Parametric Mapping was applied to determine fractional anisotropy (FA) changes for the entire brain in order to identify areas correlated with motor recovery. RESULTS: Fugl-Meyer sc...
Source: Restorative Neurology and Neuroscience - January 25, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Grey matter connectivity within and between auditory, language and visual systems in prelingually deaf adolescents.
CONCLUSIONS: Our results indicate "cross-modal" plasticity after deprivation of the auditory input in prelingually deaf adolescents, especially between auditory and visual systems. Besides, auditory deprivation and visual deficits might affect the connectivity pattern within language and visual systems in prelingually deaf adolescents. PMID: 25698109 [PubMed - in process] (Source: Restorative Neurology and Neuroscience)
Source: Restorative Neurology and Neuroscience - January 25, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research