Author index
(Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - January 25, 2022 Category: Research Tags: Author Index Source Type: research

2022 Southern Medical Research Conference
(Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - January 25, 2022 Category: Research Tags: Abstracts Source Type: research

Retrospective evaluation of patients with and without 14-day readmissions following hospitalization for COVID-19
Hospitalized patients with COVID-19 must have a safe discharge plan to prevent readmissions. We assessed patients with COVID-19 admitted to hospitals belonging to a single health system between April 2020 and June 2020. Demographics, vitals and laboratory data were obtained by electronic data query and discharge processes were reviewed by manual abstraction. Over the study period, 94 out of 912 (10.3%) patients were readmitted within 14 days of discharge. Readmitted patients were older and spent more time in the intensive care unit (p
Source: Journal of Investigative Medicine - January 25, 2022 Category: Research Authors: Subramoney, K., Elsheikh, O., Butt, S., Romano, D., Reese, L., Kara, A. Tags: COVID-19 Brief report Source Type: research

Metabolic effects of medical cannabis treatment
In this study, we prospectively evaluated patients recently starting medical cannabis treatment. All patients from the rheumatology clinic, who were just approved for medical cannabis treatment for resistant chronic pain, were recruited. After consent, demographic and clinical parameters were documented, including indication for medical cannabis treatment, way of consumption, type of cannabis and monthly dose of medical cannabis. Fasting morning blood glucose, hemoglobin A1c, insulin, lipid profile, cortisol and uric acid levels, in addition to body weight, were obtained just prior to and 3 months following cannabis consum...
Source: Journal of Investigative Medicine - January 25, 2022 Category: Research Authors: Habib, G., Aamar, S. Tags: Brief report Source Type: research

Depressive symptomatology in adults during the COVID-19 pandemic
Depression entails changes in the mental health of individuals worldwide. Episodes of depression lead to mood swings and changes in the motivational dimension. Our research focused on the prevalence of depression in the adult population and on how it affected the social and affective dimensions. Owing to the current pandemic, we deemed it necessary to explore how protective measures against COVID-19 infection, such as quarantines, could be related to mental health. Moreover, we found it important to determine the prevalence of depressive and anxious symptomatology in adults from the Valle del Cauca region in Colombia durin...
Source: Journal of Investigative Medicine - January 25, 2022 Category: Research Authors: Ocampo Gonzalez, A. A., Castillo Garcia, J. F., Pabon Sandoval, L. C., Tovar Cuevas, J. R., Hidalgo Ibarra, S. A., Calle Sandoval, D. A., Cortes Gonzalez, E., Garcia Chica, K. S., Pabon Lozano, J. S., Munoz Rico, M. d. C. Tags: Open access, COVID-19 Original research Source Type: research

Relationship between stress and alexithymia, emotional processing and negative/positive affect in medical staff working amid the COVID-19 pandemic
This study used path analysis to analyze the relationship between stress and alexithymia, emotional processing and negative/positive affect in healthcare workers. The sample included 167 nurses, 65 physicians and 53 paramedics. Sixty-two (21.75 %) respondents worked in COVID-19-designated hospitals. Respondents were administered the Toronto Alexithymia Scale-20, Cohen’s Perceived Stress Scale, Emotional Processing Scale, and the Positive and Negative Affect Schedule. The model showed excellent fit indices (2 (2)=2.642, p=0.267; CFI=0.999, RMSEA=0.034, SRMR=0.015). Multiple group path analysis demonstrated physicians ...
Source: Journal of Investigative Medicine - January 25, 2022 Category: Research Authors: Warchoł-Biedermann, K., Bugajski, P., Budzicz, Łukasz, Ziarko, M., Jasielska, A., Samborski, W., Daroszewski, P., Greberski, K., Baczyk, G., Karon, J., Mojs, E. Tags: COVID-19 Original research Source Type: research

Performance features and mortality prediction of the 4C Score early in COVID-19 infection: a retrospective study in Saudi Arabia
The ISARIC4C consortium developed and internally validated the 4C Score for prediction of mortality only in hospitalized patients. We aimed to assess the validity of the 4C Score in mortality prediction of patients with COVID-19 who had been home isolated or hospitalized. This retrospective cross-sectional study was performed after the first wave of COVID-19. Data of all PCR-positive COVID-19 patients who had been discharged, hospitalized, or died were retrospectively analyzed. Patients were classified into four risk groups according to the 4C Mortality Score. A total of (506) patients were classified as follows: low (57.1...
Source: Journal of Investigative Medicine - January 25, 2022 Category: Research Authors: Mohamed, R. A. E., Abdelsalam, E. M., Maghraby, H. M., Al Jedaani, H. S., Rakha, E. B., Hussain, K., Sultan, I. Tags: COVID-19 Original research Source Type: research

Prospective predictive performance comparison between clinical gestalt and validated COVID-19 mortality scores
Most COVID-19 mortality scores were developed at the beginning of the pandemic and clinicians now have more experience and evidence-based interventions. Therefore, we hypothesized that the predictive performance of COVID-19 mortality scores is now lower than originally reported. We aimed to prospectively evaluate the current predictive accuracy of six COVID-19 scores and compared it with the accuracy of clinical gestalt predictions. 200 patients with COVID-19 were enrolled in a tertiary hospital in Mexico City between September and December 2020. The area under the curve (AUC) of the LOW-HARM, qSOFA, MSL-COVID-19, NUTRI-Co...
Source: Journal of Investigative Medicine - January 25, 2022 Category: Research Authors: Soto-Mota, A., Marfil-Garza, B. A., Castiello-de Obeso, S., Martinez Rodriguez, E. J., Carrillo Vazquez, D. A., Tadeo-Espinoza, H., Guerrero Cabrera, J. P., Dardon-Fierro, F. E., Escobar-Valderrama, J. M., Alanis-Mendizabal, J., Gutierrez-Mejia, J. Tags: COVID-19 Original research Source Type: research

Serum magnesium levels in hospitalized patients with SARS-CoV-2
This study evaluated the outcomes of hypermagnesemia in patients with COVID-19. A retrospective chart review of patients admitted to the hospital with confirmed SARS-CoV-2 infection was conducted. A review of the medical literature regarding hypermagnesemia, magnesium levels in critical care illness and electrolyte abnormalities in patients with COVID-19 was performed. Differences in demographic and clinical characteristics of patients with hypermagnesemia and normomagnesemia were evaluated using descriptive statistics. Other known variables of disease severity were analyzed. 104 patients (54%) were identified with hyperma...
Source: Journal of Investigative Medicine - January 25, 2022 Category: Research Authors: Sharma, R., Heidari, A., Johnson, R. H., Advani, S., Petersen, G. Tags: COVID-19 Original research Source Type: research

Venous capacitance and venous return in young adults with typical vasovagal syncope: a cross-sectional study
In conclusion, at baseline, VC and VR are not impaired in healthy volunteers with a history of VVS. It remains unknown if similar results would be found in patients with cardiovascular comorbidities. Also, the sensitivity of VC and VR evaluations to identify a predisposition for VVS following physiological provocations merits further study. (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - January 25, 2022 Category: Research Authors: Fish, E., Barak Lanciano, S., Shavit, I., Palacci, H., Chaiat, C., Avivi, I., Haber Kaptsenel, E., Nussinovitch, U. Tags: Original research Source Type: research

Incidence and risk factors for mucormycosis in renal transplant patients
Conclusions In renal transplant patients, age, deceased donor graft transplant, tacrolimus administration, race other than white, and Hispanic ethnicity were associated with increased risk of mucormycosis. Unexpectedly, iron overload was protective. Mucormycosis is a rare infection in renal transplant patients which should be considered in patients with the above risk factors after more common infections have been ruled out. (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - January 25, 2022 Category: Research Authors: Downey, M. R., Taskar, V., Linder, D. F., Baer, S. L., Waller, J. L., Bollag, W. B., Kheda, M., Mohammed, A., Padala, S. Tags: Original research Source Type: research

Predictive role of ultrasound remission for progressive ultrasonography-detected structural damage in patients with rheumatoid arthritis
Regarding the persistence of subclinical synovitis, the concept of ultrasound remission has been proposed in addition to clinical remission. However, there have been no studies that explored the different time points of ultrasound remission to predict non-progressive structural damage. Given this, the aim of our study is to explore whether early ultrasound remission in patients with rheumatoid arthritis (RA) has predictive value for non-progressive structural damage in the subsequent 12 months. Sixty-one patients with RA were prospectively studied. Synovial hypertrophy, power Doppler (PD) signal, and bone erosions of bilat...
Source: Journal of Investigative Medicine - January 25, 2022 Category: Research Authors: Liu, F., Li, W., Zhu, J., Liu, F., Fan, W., Chen, Z. Tags: Original research Source Type: research

Septic arthritis in the end-stage renal disease population
We examined the incidence, risk factors and sequelae of septic arthritis in a cohort of hemodialysis patients. The US Renal Data System was queried for diagnoses of septic arthritis and selected sequelae using International Statistical Classification of Diseases and Related Health Problems-9 and Current Procedural Terminology-4 codes in patients who initiated hemodialysis between 2005 and 2010. Multivariable logistic regression was used to determine potential risk factors for septic arthritis and its sequelae. 7009 cases of septic arthritis were identified, an incidence of 514.8 per 100,000 persons per year. Of these patie...
Source: Journal of Investigative Medicine - January 25, 2022 Category: Research Authors: Aitkens, L., Winn, M., Waller, J. L., Huber, L., Baer, S. L., Mohammed, A., Kheda, M., Tran, S., Siddiqui, B., Padala, S., Colombo, R. E., Bollag, W. B. Tags: Original research Source Type: research

Treatment and outcomes among patients >=85 years hospitalized with community-acquired pneumonia
In conclusion, patients aged ≥85 have different comorbidities and etiologies of CAP, receive less intense treatment, and have greater mortality than patients between 65 and 75 years. (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - January 25, 2022 Category: Research Authors: Rastogi, R., Yu, P.-C., Deshpande, A., Hashmi, A. Z., Herzig, S. J., Rothberg, M. B. Tags: Original research Source Type: research

N-terminal pro-brain natriuretic peptide is an independent predictor of mortality in patients with sepsis
This study aims to evaluate the role of cardiac enzymes N-terminal pro-brain natriuretic peptide (NT-proBNP) and cardiac troponin-I (CTnI) as predictors of outcomes in patients with sepsis. 78 cases with a diagnosis of sepsis were enrolled over a 2-year period. Baseline demographic, Acute Physiology and Chronic Health Evaluation-II (APACHE-II), Simplified Acute Physiology Score-II (SAPS-II), hematologic and biochemical parameters were noted. Serum NT-proBNP and CTnI were evaluated at 24 and 72 hours of admission along with echocardiography. Patients were prospectively followed up until death or discharge. Mean APACHE-II sc...
Source: Journal of Investigative Medicine - January 25, 2022 Category: Research Authors: Biswas, S., Soneja, M., Makkar, N., Farooqui, F. A., Roy, A., Kumar, A., Nischal, N., Biswas, A., Wig, N., Sood, R., Sreenivas, V. Tags: Original research Source Type: research

Neuroimaging risk factors for participation restriction after acute ischemic stroke: 1-year follow-up study
The aim of the present study was to determine the neuroimaging predictors of poor participation after acute ischemic stroke. A total of 443 patients who had acute ischemic stroke were assessed. At 1-year recovery, the Reintegration to Normal Living Index was used to assess participation restriction. We also assessed the Activities of Daily Living Scale and modified Rankin Scale (mRS) score. Brain MRI measurement included acute infarcts and pre-existing abnormalities such as enlarged perivascular spaces, white matter lesions, ventricular-brain ratio, and medial temporal lobe atrophy (MTLA). The study included 324 men (73.1%...
Source: Journal of Investigative Medicine - January 25, 2022 Category: Research Authors: Qu, J.-F., Zhong, H.-H., Liang, W.-C., Chen, Y.-K., Liu, Y.-L., Li, W. Tags: Open access Original research Source Type: research

Artificial intelligence to diagnose ear disease using otoscopic image analysis: a review
AI relates broadly to the science of developing computer systems to imitate human intelligence, thus allowing for the automation of tasks that would otherwise necessitate human cognition. Such technology has increasingly demonstrated capacity to outperform humans for functions relating to image recognition. Given the current lack of cost-effective confirmatory testing, accurate diagnosis and subsequent management depend on visual detection of characteristic findings during otoscope examination. The aim of this manuscript is to perform a comprehensive literature review and evaluate the potential application of artificial in...
Source: Journal of Investigative Medicine - January 25, 2022 Category: Research Authors: Canares, T. L., Wang, W., Unberath, M., Clark, J. H. Tags: Review Source Type: research

LECT-2 amyloidosis: what do we know?
Amyloidosis is a rare group of diseases characterized by abnormal folding of proteins and extracellular deposition of insoluble fibrils. It can be localized to one organ system or can have systemic involvement. The kidney is the most common organ to be involved in systemic amyloidosis often leading to renal failure and the nephrotic syndrome. The two most common types of renal amyloidosis are immunoglobulin light chain-derived amyloidosis (AL) and reactive amyloidosis (AA). A novel form of amyloidosis (ALECT2) derived from leukocyte chemotactic factor 2 (LECT-2) and primarily involving the kidneys was first described by Be...
Source: Journal of Investigative Medicine - January 25, 2022 Category: Research Authors: Mann, B. K., Bhandohal, J. S., Cobos, E., Chitturi, C., Eppanapally, S. Tags: Editor's choice Review Source Type: research

Yet another amyloidosis
(Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - January 25, 2022 Category: Research Authors: Means, R. T. Tags: Editorial Source Type: research

Author index
(Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - December 23, 2021 Category: Research Tags: Author index Source Type: research

2022 Western Medical Research Conference
(Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - December 23, 2021 Category: Research Tags: Abstracts Source Type: research

Estimating clinical research project duration from idea to publication
(Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - December 23, 2021 Category: Research Authors: Tumin, D., Brewer, K. L., Cummings, D. M., Keene, K. L., Campbell, K. M. Tags: COVID-19 Letter to the Editor Source Type: research

In-vivo skeletal muscle mitochondrial function in Klinefelter syndrome
In this study, in-vivo postexercise skeletal muscle mitochondrial function does not appear to be impaired in adolescents with XXY compared with controls and is not significantly different by testosterone treatment status in XXY. (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - December 23, 2021 Category: Research Authors: Cung, S., Pyle, L., Nadeau, K., Dabelea, D., Cree-Green, M., Davis, S. M. Tags: Brief report Source Type: research

Impact on the fitness of N95 masks with extended use/limited reuse and dry heat decontamination
Substandard use of N95 masks, sometimes combined with dry heat decontamination, lacks safety data. We evaluated the impact of these practices on the fitness of N95 masks. This is a non-human subject research conducted from July to October 2020. 155 masks were used by 12 healthcare workers during 10-hour shifts. Masks were collected at the end of the shift and if the number of donnings/doffings was less than five (‘modified extended use’, ME) or whenever this number reached five (‘limited reuse’, LR), per the recommendation of the Centers for Disease Control and Prevention. Masks that passed an Occup...
Source: Journal of Investigative Medicine - December 23, 2021 Category: Research Authors: Zha, M., Alsarraj, J., Bunch, B., Venzon, D. Tags: Open access, COVID-19 Original research Source Type: research

Protective effects of sunscreen (50+) and octatrienoic acid 0.1% in actinic keratosis and UV damages
Actinic keratosis is a form of dysplastic epidermal lesion resulting from chronic and excessive UV exposure with a certain risk of becoming cancerous. Current guidelines advocated the use of sunscreens to prevent photodamage. An efficient photoprotection must involve both primary protective factors such as UV filters and secondary factors (eg, antioxidants) able to disrupt the photochemical and genetic cascade triggered by UVs. An in vitro model of human skin (Phenion FT) was used to assess the photoprotective potential of a sunscreen containing inorganic sun-filters (50+ SPF) and 0.1% octatrienoic acid (KERA’+) afte...
Source: Journal of Investigative Medicine - December 23, 2021 Category: Research Authors: Pinto, D., Trink, A., Giuliani, G., Rinaldi, F. Tags: Open access Original research Source Type: research

Education can improve clinician confidence in information sharing and willingness to refer to stem cell clinical trials for cerebral palsy
To progress stem cell therapies for cerebral palsy, clinicians need to openly engage with patients about emerging evidence and be willing to refer to relevant clinical trials, if and when appropriate. To assess whether education can change clinicians’ confidence in information sharing and willingness to refer to relevant clinical trials, an online questionnaire was distributed at a scientific conference before and after a professional workshop on cell therapies for cerebral palsy. Of the 42 participants who completed the survey, 26 self-identified as clinicians. Of these, 81% had had patients ask about stem cells, ye...
Source: Journal of Investigative Medicine - December 23, 2021 Category: Research Authors: Paton, M. C. B., Finch-Edmondson, M., Galea, C., Garrity, N., Fahey, M. C., Novak, I. Tags: Original research Source Type: research

Associations between GDF15 levels and pre-diabetes in non-obese subjects
Growth differentiation factor 15 (GDF15) is a stress-response cytokine which belongs to the transforming growth factor β superfamily. Although GDF15 was initially found to have a role in metabolic diseases, the association between GDF15 and dysglycemic status remains inconclusive. Thus, the aim of this study was to examine the relationships between GDF15 and different glycemic statuses in non-obese subjects. We enrolled 502 non-obese subjects, among individuals who had normal glucose tolerance (NGT; n=125), isolated impaired fasting glucose (IFG; n=116), isolated impaired glucose tolerance (IGT; n=106), IFG plus IGT (...
Source: Journal of Investigative Medicine - December 23, 2021 Category: Research Authors: Hung, H.-C., Wu, H.-T., Lin, C.-H., Chou, H.-W., Ou, H.-Y., Chang, C.-J. Tags: Original research Source Type: research

Prevalence and predictors of colonoscopic findings in patients with autoimmune gastritis
The clinical spectrum of autoimmune gastritis is silent in the early stages of the disease and no specific symptom is related to this entity. Although gastroscopic findings of this entity are well defined, data regarding colonoscopic findings are limited. The aims of this study were to determine the prevalence of colonoscopic findings and to explore factors that might affect these findings. This is a retrospective chart review of patients with autoimmune gastritis (n=240). Data regarding colonoscopic findings, serum gastrin and chromogranin A (CgA) levels and gastric histopathological results were extracted and compared wi...
Source: Journal of Investigative Medicine - December 23, 2021 Category: Research Authors: Asfuroglu Kalkan, E., Kalkan, C., Gumussoy, M., Gucbey, O., Soykan, I. Tags: Original research Source Type: research

Association between blood carboxyhemoglobin level and bronchopulmonary dysplasia in extremely low birthweight infants
The objective of the study is to evaluate the relationship between blood CO-Hb levels in the first 14 days of life (DOL) in ELBW infants and the development of BPD at 36 weeks postmenstrual age (PMA). This is a retrospective cohort study of 58 ELBW infants born at LAC-USC Medical Center between June 2015 and and June 2019 who survived to 36 weeks PMA. CO-Hb values were collected daily from DOL 1 to DOL 14. BPD definition using the recent 2019 NICHD criteria was used. Multivariate logistic regression was performed to determine the association between blood CO-Hb levels and BPD. Receiver operator curve was used to evaluate t...
Source: Journal of Investigative Medicine - December 23, 2021 Category: Research Authors: Tagliaferro, T., Cayabyab, R., Ramanathan, R. Tags: Original research Source Type: research

Long COVID following mild SARS-CoV-2 infection: characteristic T cell alterations and response to antihistamines
This study demonstrates that T cell perturbations persist for several months after mild COVID-19 and are associated with long COVID symptoms. (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - December 23, 2021 Category: Research Authors: Glynne, P., Tahmasebi, N., Gant, V., Gupta, R. Tags: Open access, COVID-19 Original research Source Type: research

Tocilizumab in patients hospitalized with COVID-19 pneumonia: systematic review and meta-analysis of randomized controlled trials
Tocilizumab is an interleukin receptor inhibitor that has been used in patients with COVID-19 pneumonia. There are recent randomized controlled trials (RCTs) that evaluated the efficacy and safety of tocilizumab in hospitalized patients with COVID-19 pneumonia. We performed a systematic review and meta-analysis of RCTs that evaluated the effectiveness of tocilizumab in hospitalized patients with COVID-19 not requiring mechanical ventilation. RCTs comparing tocilizumab with the standard of care treatment in hospitalized patients with COVID-19 pneumonia not requiring mechanical ventilation at the time of administration were ...
Source: Journal of Investigative Medicine - December 23, 2021 Category: Research Authors: Gupta, S., Padappayil, R. P., Bansal, A., Daouk, S., Brown, B. Tags: COVID-19 Original research Source Type: research

Exploring the appropriate dose of nebulized hypertonic saline for bronchiolitis: a dose-response meta-analysis
This study aims to evaluate the relationship between the dose of nebulized HS and the effects on bronchiolitis. Five electronic databases—PubMed, EMBASE, Cochrane Central Register of Controlled Trials, ClinicalTrials.gov, and ISRCTN—were searched until May 2021. Randomized controlled trials (RCTs) that investigated the effect of HS on bronchiolitis were included. A total of 35 RCTs met the eligibility criteria. HS nebulization may shorten the length of stay (LOS) in hospital (mean difference –0.47, 95% CI –0.71 to –0.23) and improve the 24-hour, 48-hour, and 72-hour Clinical Severe Score (CSS)...
Source: Journal of Investigative Medicine - December 23, 2021 Category: Research Authors: Lin, J., Zhang, Y., Song, A., Ying, L., Dai, J. Tags: Original research Source Type: research

Nocardiosis in renal transplant patients
This study provides new information to enhance early recognition and targeted treatment of nocardiosis in renal transplant patients. (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - December 23, 2021 Category: Research Authors: Gibson, M., Yang, N., Waller, J. L., Young, L., Bollag, W. B., Kheda, M., Mohammed, A., Baer, S. L. Tags: Original research Source Type: research

Quantitative increase in short-chain fatty acids, especially butyrate protects kidney from ischemia/reperfusion injury
In this study, we explore butyrate effect on renal I/R injury and SCFAs changes in renal transplant. Male Sprague-Dawley rats were pretreated with butyrate as research, and underwent the surgery of renal ischemia for 45 min followed by reperfusion. 90 rats were randomly divided into 3 groups (n=30 each group): (1) sham-operated group; (2) butyrate-treated group; (3) control group. The samples of blood and renal were collected immediately for further studies. Thirty-two patients were enrolled to investigate the levels of SCFAs after the renal transplantation. Rats model showed that butyrate treatments significantly enhanced...
Source: Journal of Investigative Medicine - December 23, 2021 Category: Research Authors: Sun, Y., Zhou, C., Chen, Y., He, X., Gao, F., Xue, D. Tags: Open access Original research Source Type: research

Effects of maslinic acid on cardiac function in ischemia-reperfusion injury rats
Maslinic acid (MA), a pentacyclic triterpenoid, has been reported to exert broad pharmacological properties. However, it is still unclear whether MA exhibits protective effects against ischemia/reperfusion (I/R) injury. Herein, we aimed to investigate the effects of MA on I/R injury and its underlying mechanisms. A rat model of I/R injury was established and administrated with MA by intraperitoneal injection. Cardiac function was assessed with a color ultrasound diagnosis system and PowerLab system. The levels of oxidative stress-related and I/R-related biomarkers were evaluated by using commercial kits. Apoptosis-related ...
Source: Journal of Investigative Medicine - December 23, 2021 Category: Research Authors: Wang, N., Ma, Z., Chen, C., Xiao, N. Tags: Original research Source Type: research

Pregnancy in patients with multiple sclerosis
This study aims to explore the association between MS and pregnancy. Articles related to the topic under investigation were identified; the search terms included "pregnancy", "multiple sclerosis", "MS", and "women". Only articles published between 2010 and 2020 were included in the review. This review shows that researchers have attempted to explore the link between pregnancy and MS, and the results from previous studies indicate that pregnancy reduces the risk of MS relapse. However, evidence suggesting that pregnancy can affect the long-term progression of MS is lacking. The resear...
Source: Journal of Investigative Medicine - December 23, 2021 Category: Research Authors: Arneth, B. M. Tags: Review Source Type: research

Wegovy (semaglutide): a new weight loss drug for chronic weight management
Obesity is a growing epidemic within the USA. Because weight gain is associated with an increased risk of developing life-threatening comorbidities, such as hypertension or type 2 diabetes, there is great interest in developing non-invasive pharmacotherapeutics to help combat obesity. Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of antidiabetic medications that have shown promise in encouraging glycemic control and promoting weight loss in patients with or without type 2 diabetes. This literature review summarizes and discusses the weight loss results from the SUSTAIN (Semaglutide Unabated Sustainability i...
Source: Journal of Investigative Medicine - December 23, 2021 Category: Research Authors: Singh, G., Krauthamer, M., Bjalme-Evans, M. Tags: Open access, Editor's choice Review Source Type: research

Semaglutide 2.4 mg: the latest GLP-1RA approved for obesity
(Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - December 23, 2021 Category: Research Authors: Villela, R., Correa, R. Tags: Editorial Source Type: research

Obesity and GLP-1 RAs
(Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - December 23, 2021 Category: Research Authors: Bright, T. Tags: Editorial Source Type: research

Correction: Comparison of acute kidney injury in patients prescribed vancomycin in combination with piperacillin-tazobactam or cefepime for diabetic foot infections
(Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - November 25, 2021 Category: Research Tags: Miscellaneous Source Type: research

Correction: Association of vitamin D with incident glaucoma: findings from the Womens Health Initiative
(Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - November 25, 2021 Category: Research Tags: Miscellaneous Source Type: research

Correction: Coccidioidomycosis: a review
(Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - November 25, 2021 Category: Research Tags: Open access Miscellaneous Source Type: research

Response to: Correspondence on 'Role of AMPK/mTOR-independent autophagy in clear cell renal cell carcinoma by Lorzadeh et al
(Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - November 25, 2021 Category: Research Authors: Radovanovic, M., Vidicevic, S., Tasic, J., Tomonjic, N., Stanojevic, Z., Nikic, P., Vuksanovic, A., Dzamic, Z., Bumbasirevic, U., Isakovic, A., Trajkovic, V. Tags: Letter to the editor Source Type: research

Correspondence on 'Role of AMPK/mTOR-independent autophagy in clear cell renal cell carcinoma by Radovanovic et al
(Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - November 25, 2021 Category: Research Authors: Lorzadeh, S., Ghavami, S. Tags: Letter to the editor Source Type: research

Variation in clinical characteristics, outcomes, and mortality of hospitalized patients with COVID-19 during the second wave of the pandemic: a single-center experience
As of February 2, 2021, the USA has 26,431,799 reported COVID-19 cases with 446,744 deaths. A high mortality rate (15%–40%) was reported among hospitalized patients with COVID-19 during the first wave of the pandemic. However, data regarding variation in COVID-19-related mortality and severity of illness among hospitalized patients with COVID-19 are heterogeneous. In this retrospective single-center study, we aimed to investigate the demographic characteristics, clinical presentations, disease severity, clinical outcomes, and in-hospital mortality of hospitalized patients with COVID-19 during the second wave of the p...
Source: Journal of Investigative Medicine - November 25, 2021 Category: Research Authors: Mughal, M. S., Kaur, I. P., Wang, C., Alhashemi, R., Buemio, A., Patton, C. D., Granet, K. M. Tags: COVID-19 Brief report Source Type: research

Predictors of misperceptions, risk perceptions, and personal risk perceptions about COVID-19 by country, education and income
Government interventions, such as mandating the use of masks and social distancing, play crucial roles in controlling the spread of pandemic infection. Adherence depends on public perceptions about pandemic risk. The goal was to explore the roles of education, income, and country on misperceptions, risk perceptions and personal risk perceptions about COVID-19. Data were extracted from 3 preregistered surveys. Binary logistic regressions were conducted to investigate the roles country, education, and income had on outcome variables. Across the USA, Canada, and UK, individuals in the highest income quartile were significantl...
Source: Journal of Investigative Medicine - November 25, 2021 Category: Research Authors: Bhuiya, T., Klares III, R., Conte, M. A., Cervia, J. S. Tags: COVID-19 Original research Source Type: research

A randomized controlled trial on the effect of dietary guidance on the treatment of Henoch-Schonlein purpura in children
The amino acid-based formulae were extensively added to diet of children for the treatment of Henoch-Schonlein purpura (HSP), and the nutrition and growth situation of children were evaluated after giving new dietary intervention. Patients were randomly divided into restricted diet group (n=30) and dietary guidance group (n=30). Besides, 30 cases with bronchiolitis who had normal diet were selected as the control group. The dietary questionnaire was designed to record the types and intakes of various foods taken by children every day, and the intake levels of nutrients were analyzed. Physical examination, biochemical analy...
Source: Journal of Investigative Medicine - November 25, 2021 Category: Research Authors: Wang, L., Yin, C., Zhang, M., Mao, H., Hao, H., Hu, X., Xue, W. Tags: Original research Source Type: research

Biomarker-based score for predicting in-hospital mortality of children admitted to the intensive care unit
This study aims to establish a new scoring system based on biomarkers for predicting in-hospital mortality of children admitted to the pediatric intensive care unit (PICU). The biomarkers were chosen using the least absolute shrinkage and selection operator (LASSO)-logistic regression in this observational case-control study. The performance of the new predictive model was evaluated by the area under the receiver operating characteristic curve (AUC). Calibration plot was established to validate the new score accompanied by the Hosmer-Lemeshow test. There were 8818 patients included in this study. Finally, six predictors we...
Source: Journal of Investigative Medicine - November 25, 2021 Category: Research Authors: Zhang, Y., Shi, Q., Zhong, G., Lei, X., Lin, J., Fu, Z., Dai, J. Tags: Original research Source Type: research