Author index
(Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - January 10, 2018 Category: Research Tags: Author index Source Type: research

Western Medical Research conference (formerly Western Regional Meeting), January 25-27 2018, Carmel, California
(Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - January 10, 2018 Category: Research Tags: Saturday, January 27, 2018 Source Type: research

Western medical research conference (formerly western regional meeting)
(Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - January 10, 2018 Category: Research Tags: ABSTRACTS [amp ] AWARD WINNERS Source Type: research

Preoperative staging of cholangiocarcinoma and biliary carcinoma using 18F-fluorodeoxyglucose positron emission tomography: a meta-analysis
In conclusion, 18F-FDG-PET and PET/CT were found to be accurate in the evaluation of primary tumors, lymph node metastasis, and distant metastasis in patients with CCA. (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - January 10, 2018 Category: Research Authors: Hu, J.-H., Tang, J.-h., Lin, C.-H., Chu, Y.-Y., Liu, N.-J. Tags: Hematology/Oncology Source Type: research

Clinical definition of respiratory viral infections in young children and potential bronchiolitis misclassification
Viral respiratory infections are often grouped as a single respiratory syndrome named ‘viral bronchiolitis’, independently of the viral etiology or individual risk factors. Clinical trials and guidelines have used a more stringent definition of viral bronchiolitis, including only the first episode of wheezing in children less than 12 months of age without concomitant respiratory comorbidities. There is increasing evidence suggesting that this definition is not being followed by pediatric care providers, but it is unclear to what extent viral respiratory infections are currently misclassified as viral bronchioli...
Source: Journal of Investigative Medicine - January 10, 2018 Category: Research Authors: Megalaa, R., Perez, G. F., Kilaikode-Cheruveettara, S., Kotwal, N., Rodriguez-Martinez, C. E., Nino, G. Tags: Pediatrics/Neonatology Source Type: research

MicroRNA-15b deteriorates hypoxia/reoxygenation-induced cardiomyocyte apoptosis by downregulating Bcl-2 and MAPK3
In conclusion, miRNA-15b deteriorates cardiomyocyte apoptosis by post-transcriptionally downregulating the expression of Bcl-2 and MAPK3. (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - January 10, 2018 Category: Research Authors: Liu, Y., Yang, L., Yin, J., Su, D., Pan, Z., Li, P., Wang, X. Tags: Original research Source Type: research

Serpinb3 is overexpressed in the liver in presence of iron overload
In conclusion, Serpinb3 is strongly induced by iron in the mouse liver. The molecular link between iron, ROS and SerpinB3 seems to be HIF-2α, which is induced by iron overload and was previously found capable of up-regulating SerpinB3 at the transcriptional level. (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - January 10, 2018 Category: Research Authors: Turato, C., Kent, P., Sebastiani, G., Cannito, S., Morello, E., Terrin, L., Biasiolo, A., Simonato, D., Parola, M., Pantopoulos, K., Pontisso, P. Tags: Original research Source Type: research

Association of gender-specific risk factors in metabolic and cardiovascular diseases: an NHANES-based cross-sectional study
In the present cross-sectional study, based on National Health and Nutrition Examination Survey (NHANES, 2007–2010) cohorts, various risk factors for metabolic syndrome (MetS) and cardiovascular diseases (CVDs) were analyzed (n=12,153). The variables analyzed include, demographics, comorbidities associated with MetS or CVD, behavioral and dietary factors, while the primary endpoints were the prevalence of MetS and CVD. The prevalence of MetS and CVD was slightly higher in males as compared with females (42.50% and 7.65% vs 41.29% and 4.13%, respectively). After controlling for confounding factors, advanced age, famil...
Source: Journal of Investigative Medicine - January 10, 2018 Category: Research Authors: Zhang, X.-E., Cheng, B., Wang, Q., Wan, J.-J. Tags: Preventive Medicine Source Type: research

PAI-1 levels are related to insulin resistance and carotid atherosclerosis in subjects with familial combined hyperlipidemia
Familial combined hyperlipidemia (FCH) is a primary atherogenic dyslipidemia with insulin resistance and increased cardiovascular risk. Plasminogen activator inhibitor type 1 (PAI-1) and myeloperoxidase (MPO) activity are associated with proinflammatory and atherothrombotic risk. Our aim was to study the role played by PAI-1 and MPO activity in the carotid atherosclerosis prevalence in FCH subjects. 36 FCH unrelated subjects (17 women) were matched by age and body weight with 36 healthy normolipidemic subjects (19 female). Blood lipids, glucose, insulin, insulin resistance (homeostasis model assessment (HOMA)), MPO, and PA...
Source: Journal of Investigative Medicine - January 10, 2018 Category: Research Authors: Carratala, A., Martinez-Hervas, S., Rodriguez-Borja, E., Benito, E., Real, J. T., Saez, G. T., Carmena, R., Ascaso, J. F. Tags: Original research Source Type: research

Determining the mechanisms of dietary turnip rapeseed oil on cholesterol metabolism in men with metabolic syndrome
We have earlier reported the reduction of total cholesterol, low-density lipoprotein (LDL) cholesterol and oxidized LDL caused by short-term modification of diet with cold-pressed turnip rapeseed oil (CPTRO) instead of butter. The aim of this supplementary study was to determine whether the beneficial effects resulted from altered cholesterol metabolism during the intervention. Thirty-seven men with metabolic syndrome (MetS) completed an open, randomized and balanced crossover study. Subjects’ usual diet was supplemented with either 37.5 g of butter or 35 mL of CPTRO for 6–8 weeks. Otherwise normal dietary habi...
Source: Journal of Investigative Medicine - January 10, 2018 Category: Research Authors: Saarinen, H. J., Sittiwet, C., Simonen, P., Nissinen, M. J., Stenman, U.-H., Gylling, H., Palomäki, A. Tags: Open access Cardiovascular/Lipidology Source Type: research

Glucagon like peptide-1 receptor agonists for the management of obesity and non-alcoholic fatty liver disease: a novel therapeutic option
Obesity is a major risk factor for the development of type 2 diabetes mellitus (T2DM), and is associated with a cluster of metabolic factors that lead to poor cardiovascular outcomes. In non-alcoholic fatty liver disease (NAFLD), liver fat (triglyceride) accumulation closely mirrors adipose tissue dysfunction and insulin resistance in obesity and T2DM. It is now recognized as the most common chronic liver disease in Westernized societies, often progressing to more severe forms of the disease such as nonalcoholic steatohepatitis (NASH), or cirrhosis and hepatocellular carcinoma. However, NAFLD remains largely overlooked by ...
Source: Journal of Investigative Medicine - January 10, 2018 Category: Research Authors: Dhir, G., Cusi, K. Tags: Editor's choice Endocrinology/Metabolism Source Type: research

Innovative strategies to increase resident scholarly activity and engage faculty support
(Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - January 10, 2018 Category: Research Authors: Das, S. U., Bar-on, M. E. Tags: PostScript Source Type: research

Analysis of nationwide trends and outcomes of percutaneous endoscopic gastrostomy (PEG) tube placement in hospitalized patients with cancer over a 13-year period
(Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - January 10, 2018 Category: Research Authors: Guddati, A. K., Kumar, G., Shapira, I. Tags: PostScript Source Type: research

Induction of deubiquitinating enzyme USP50 during erythropoiesis and its potential role in the regulation of Ku70 stability
This study suggests that DUBs like USP50 may regulate protein stability during erythropoiesis; however, more investigation is warranted. (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - January 10, 2018 Category: Research Authors: Cai, J., Wei, J., Schrott, V., Zhao, J., Bullock, G., Zhao, Y. Tags: Basic Science/Genetics/Molecular Medicine Source Type: research

25 Culture environmental management innovation optimisation of enrichment factor lactobacillus acidophilus
ConclusionsThe best ratio of enrichment medium was: glutamate, lysine, vitamin C. Culture temperature was 37°C, initial fermentation pH was 6.5, 4% inoculation, harvest time was 20 hours after fermentation.AcknowledgementsSupported by a project grant from Longdong University doctoral research (Grant No. XYBE1605). Central finance forestry science and technology extension demonstration project [2015] ZYTG8 Qingyang science and technology support program (NK2011-41). (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - December 5, 2017 Category: Research Authors: Li, X., Wang, D., Zhang, Z., Zhu, Y., Jia, H. Tags: Abstracts Source Type: research

24 Danggui shaoyao powder improves diabetic nephropathy without altering blood glucose in streptozotocin-induced diabetic rats
ConclusionThis study suggests that DSS could improve renal function in streptozotocin-induced DN model rats. The mechanism may be related to regulating the Th1/Th2 cell balance and improved lipid metabolism in DN rats.AcknowledgmentSupported by a project grant from The National Natural Science Foundation of China (Grant No. 81603527), Science and technology project of Henan Province (Grant No. 162102310466), Key scientific research projects of Henan Province Colleges and Universities (Grant No. 16A360010), Henan University of Traditional Chinese Medicine Scientific and technological innovation talent support program (Grant...
Source: Journal of Investigative Medicine - December 5, 2017 Category: Research Authors: Li, X., Li, Z., Zhang, L., Zhang, Y., Liu, X., Zhao, X., Liu, W., Gao, A. Tags: Abstracts Source Type: research

23 Study on mirnas prediction and co-expression patterns of the human intronic mirnas with their host genes
ConclusionsThis study not only provides some effective means for research on miRNAs prediction and co-expression prediction of intronic miRNAs with their host genes, but also gives some solid foundation for future research in this field.AcknowledgementsSupported by the National Natural Science Foundation of China (Grant No. 61402099). (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - December 5, 2017 Category: Research Authors: Wang, H., Li, B., Wu, M. Tags: Abstracts Source Type: research

22 In vivo evaluation of ethanol extract of forsythia suspensa (thunb.) vahl (fruit) in anti-inflammatory and analgesic activities
ConclusionsThese findings indicate that FSTV-ET can produce anti-inflammatory and analgesic activities in vivo, and the mechanism is likely to be related to inhibiting lipid peroxidation and inflammation.AcknowledgementsSupported by project grants from the National Natural Science Foundation of China (Grant No. 81503269), the Funding Scheme for Young Key Teachers of Colleges and Universities in Henan Province (Grant No. 2014GGJS-072), and the Science and Technology Project of Zhengzhou (Grant No. 20150309). (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - December 5, 2017 Category: Research Authors: Wang, J., Cui, Y., Chen, S., XB, L., Feng, W., Cai, H., Chen, R. Tags: Abstracts Source Type: research

21 Effect of jinjiang granules on intestinal mucosal immunity in mice model
ConclusionsJinjiang granules can improve the immune function of the mice models of hypoimmunity. It also improves intestinal immune function. It prevents colds when given as the initial medicine.AcknowledgementsThe Central Plains scholars (162101510003), the team of outstanding scientific and technological innovation in Henan province (TCJ2014-391), Henan University of Traditional Chinese Medicine and deep processing of geoherbs Collaborative Innovation Centre (2012)188–2. (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - December 5, 2017 Category: Research Authors: Miao, M., Cao, L., Qiao, J., Zhang, R. Tags: Abstracts Source Type: research

20 Gut microbiota in human adults with irritable bowel syndrome differs from healthy controls
BackgroundRecent evidence suggests that there is a link between irritable bowel syndrome (IBS) and microbiota in the gut. The onset and maintenance of IBS may be caused by gut microbiota, but the causes of the pathophysiology of this disorder are unknown.Method25 patients who fulfilled Rome III criteria for IBS and 29 age- and gender-matched healthy controls were chosen in this study. The total bacterial DNA isolated from the two populations was investigated through amplicon pyrosequencing of the V3–V4 regions of the 16S ribosomal RNA gene.ResultsThe composition of bacteria in the groups differed between healthy cont...
Source: Journal of Investigative Medicine - December 5, 2017 Category: Research Authors: Liu, Y., Wang, Y., Wen, S., Zhang, T., Tang, L. Tags: Abstracts Source Type: research

19 Experimental study on postoperative adhesions between tendon and different tissues
ConclusionPostoperative adhesions between the tendon and different tissues differ. More tissue adhesion formed between the tendon and the subcutaneous tissue than between the tendon and the remnant sheath. (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - December 5, 2017 Category: Research Authors: Su, Y., Wang, W., Meng, X., Gu, G., Yu, M., Yan, Z., Ma, Y., Dong, X., Sun, Q., Zhao, D. Tags: Abstracts Source Type: research

18 Intermittent hypoxia improves atherosclerosis associated with upregulation of hif-1{alpha} and nf-{kappa}b in aortic arch and serum of rabbits
ObjectivesTo investigate the role of HIF-1α and NF-B in intermittent hypoxia (IH) induced atherosclerosis in rabbits.MethodsNew-Zealand White rabbits were exposed to IH for 12 weeks (intermittent hypoxia of 21% O2 for 30 s and 8% O2 for 30 s, cyclically repeated for 8 h/day). We randomly assigned 48 male rabbits to groups of normoxia (RA) or IH. The rabbits in the RA group were continuously exposed to room air. After intervention of 4, 8, and 12 weeks, serum and aortic arch tissues were subjected to Elisa and immunohistochemical staining analyses respectively. The formation of atherosclerosis in the aortic arch was o...
Source: Journal of Investigative Medicine - December 5, 2017 Category: Research Authors: Pang, J., Wang, B., Li, Y., Zhang, H., Xiang, W., Hao, X., Xue, H. Tags: Abstracts Source Type: research

17 Effect of salvia miltiorrhiza on tmmrna expression in coronary artery tissue of rats with high salt induced blood stasis
ObjectiveTo understand the effect of Salvia miltiorrhiza on the cardiovascular system by the expression of tissue TMmRNA, and to provide the scientific basis for the use of Salvia miltiorrhiza and a low salt diet for the prevention and treatment of cardiovascular and cerebrovascular diseases caused by high salt intake.MethodsThirty SD rats were randomly divided into a blank group, high salt group and Salvia miltiorrhiza group. The blank group was given intragastric distilled water and the high salt and the Salvia miltiorrhiza groups were treated with intragastric administration of 12% NaCl, for 30 consecutive days. Seven d...
Source: Journal of Investigative Medicine - December 5, 2017 Category: Research Authors: Xia, L., Zhou, X., Tian, X., Zhao, Y., Fu, D., Xu, H. Tags: Abstracts Source Type: research

16 The intervention effect of total flavonoids of mao dongqing on cerebral ischaemic tolerance model in mice
ConclusionIschaemic preconditioning can induce cerebral ischaemic tolerance. The total flavonoids of Mao Dongqing and ischaemic preconditioning have a synergistic effect by inhibition of the overexpression of immediate early gene c-fos, COX-2 and improved platelet function. It can reduce brain injury and promote the formation of cerebral ischaemic tolerance. (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - December 5, 2017 Category: Research Authors: Lou, X., Bai, M., Qiao, J., Fang, X., Miao, M. Tags: Abstracts Source Type: research

15 Comparison of biomechanical characteristics on barefoot running and shod running
BackgroundCompared with the rearfoot strike pattern of shod running, barefoot running with a forefoot strike pattern will change the kinematics and kinetic parameters. This paper analyses the biomechanical differences between barefoot running and shod running and aims to provide a reference for barefoot training and the prevention of sports injury.MethodsThree-dimensional force plate test and three-dimensional video analysis.ResultsKinetic characteristics: The F-t curve by the force plate test shows that barefoot running has a smooth curve with a single peak while the F-t curve of shod running has a double peak on the vert...
Source: Journal of Investigative Medicine - December 5, 2017 Category: Research Authors: Wang, S., Zhou, J. Tags: Abstracts Source Type: research

14 The mechanism of pkcB-p66shc-nadph oxidase pathway in high glucose induced-oxidative stress in renal tubular epithelial cells
ConclusionThe study clarified a novel mechanism of oxidative stress damaging HK-2 cells via the modulation of the PKCβ-P66Shc-NADPH oxidase pathway. Understanding the molecular pathway of oxidative stress could translate into the development of therapeutic strategies for diabetic nephropathy.AcknowledgementsThis work was supported by the National Natural Science Foundation of China [No. 81400300] and Natural Science Foundation of Jiangsu Province [No. BK20130642]. (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - December 5, 2017 Category: Research Authors: Cheng, Y., Chao, J., Zhu, D., Liu, B. Tags: Abstracts Source Type: research

13 Atp-sensitive potassium channels mediate the cardioprotection of panax notoginseng saponins against myocardial ischemia reperfusion injury and inflammatory reaction
ConclusionPNS preconditioning may reduce inflammation to due to MIRI via KATP channels.AcknowledgementsSupported by a project grant from National Natural Science Foundation (NSFC) of China (Grant No. 81303256). (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - December 5, 2017 Category: Research Authors: Ning, K., Jiang, L., Yang, Z., Zheng, Q., Bao, Y. Tags: Abstracts Source Type: research

12 The igca staging system compared with ajcc7 system in stratifying survival of patients with cancer
ConclusionsThe IGCA staging system can stratify stage III gastric cancer patients more correctly than the AJCC7 system.AcknowledgementSupported by the National Natural Science Foundation of China (Grant No. 14B520013) and the Scientific Research Project from the open fund of Henan Key laboratory (Grant No. 172400410344). (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - December 5, 2017 Category: Research Authors: Wang, F. Tags: Abstracts Source Type: research

11 Meta-analysis of prognostic value of transforming growth factor-beta (tgf-{beta}) in patients
ConclusionsThis meta-analysis demonstrates that TGF-β can be used as a prognostic biomarker for CRC patients undergoing surgery, especially for CRC patients from Western countries. (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - December 5, 2017 Category: Research Authors: Wang, F. Tags: Abstracts Source Type: research

10 Knockdown of transforming growth factor beta regulator 4 (tbrg4) promotes apoptosis in human lung cancer cell line h1299 via regulating ddit3, cav1 and rrm2
AbstractTransforming growth factor beta regulator 4 (TBRG4) gene is located on 7 p14-p13, a region correlated with many cancer types, such as hematologic malignancies, head and neck squamous cell carcinoma, and multiple myeloma. However, the role of TBRG4 in human lung cancer is largely unknown. Thus, in the present study, the TBRG4 mRNA level was evaluated in the lung cancer cell line H1299 by quantitative PCR (qPCR) after knocking down TBRG4 using lentivirus-mediated small interfering RNA (siRNA). The result showed that TBRG4 was significantly inhibited in H1299 by RNAi. Microarray analysis revealed 586 differentially-ex...
Source: Journal of Investigative Medicine - December 5, 2017 Category: Research Authors: Wang, A., Liu, X., Su, W., Duan, G., Xie, Z., Chu, S. Tags: Abstracts Source Type: research

09 Exploring the genotype-phenotype associations of colorectal cancer using vector space model
ConclusionOur study provides a biomedical literature mining method for cancer translational research such as construction of a precision medicine knowledge base, biomarker prediction/evaluation, and knowledge discovery in texts.AcknowledgementsSupported by the National key research and development program of China (No. 2016YFC0901703), and the Public Projects of Zhejiang Province, China (No. 2017C33064). (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - December 5, 2017 Category: Research Authors: Deng, N., NK, D., Feng, Y., Wang, Z., Duan, H., Liu, F. Tags: Abstracts Source Type: research

08 Study of total flavonoids from mao dongqing in cerebral ischemia reperfusion models
ConclusionThe results of this study showed that the model of cerebral ischemia-reperfusion in mice was successful. The total flavonoids from MDQ could achieve the role of anti-cerebral ischemia injury by inhibition of the inflammatory cascade, improving the imbalance of oxygen supply and demand and the disorder of glucose metabolism, inhibiting the apoptosis of nerve cells during cerebral ischemia reperfusion injury.AcknowledgmentNational "Significant New Drug Creation" science and technology major special project (2009Z x 09103-324). (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - December 5, 2017 Category: Research Authors: Miao, M., Cao, L., Qiao, J., Zheng, Y., Xin, W. Tags: Abstracts Source Type: research

07 The approach to generate oncolytic adenovirus by sirna mediated e1b silencing
ConclusionIn addition to knockout of the E1B coding cassette, siRNA mediated E1B also serves as an approach to prepare oncolytic adenovirus.AcknowledgementsSupported by grants from UICC (ICRETT Fellowship), Guangdong Commission of Health and Family Plan (Grant No. 2014A276). (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - December 5, 2017 Category: Research Authors: Zhang, X., Matskova, L., Zheng, B., Ernberg, I., He, Z., Huang, Z. Tags: Abstracts Source Type: research

06 Hemicellulose-based magnetic hydrogel for enzyme drug immobilisation
ConclusionThe swelling property and high immobilisation capacity of HC/PAAc semi-IPN magnetic hydrogel could expand its applications in drug delivery.AcknowledgementsSupported by Natural Science Basic Research Plan in Shaanxi Province of China (No. 2017JM2003), and the Seed Foundation of Innovation and Creation for Graduate Students in Northwestern Polytechnical University (No. Z2017204). (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - December 5, 2017 Category: Research Authors: Ma, J., Sun, X., Yao, X., Zeng, Q. Tags: Abstracts Source Type: research

05 Core-shell medicated nanoparticles prepared using coaxial electrospray for fast dissolution of paracetamol
ConclusionCore-shell medicated nanoparticles prepared using coaxial electrospray can be an alternative approach for improving the dissolution rate of insoluble drugs.AcknowledgementsSupported by the National Natural Science Foundation of China (No. 51373101). (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - December 5, 2017 Category: Research Authors: Li, H., Zhang, L., Zhang, Y., DG, Y. Tags: Abstracts Source Type: research

04 Construction and analysis of lair-1 over-expressed nk-92 cells
ConclusionLAIR-1 over-expressed NK-92 cells were constructed successfully and the IL-2 treatment experiment showed different roles of STAT1 and STAT4 in the regulation of NK cells.AcknowledgementsSupported by a project grant from the Natural Science Foundation of Shandong Province (ZR2015JL027) and National Natural Science Foundation of China (81370730, 81571512, 81273200, and 31300751). (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - December 5, 2017 Category: Research Authors: Fu, Q., Sun, Y., Xue, J., Piao, H., Du, M., Li, D. Tags: Abstracts Source Type: research

03 Three-templates molecularly imprinted solid-phase microextraction coatings for parabens analysis in river water samples
ConclusionThe three-templates molecularly imprinted solid-phase microextraction coatings can selectively extract three parabens in real water samples.AcknowledgementsSupported by a project grant from the National Natural Science Foundation of China (Grant No. 21565018). (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - December 5, 2017 Category: Research Authors: Ma, X., Liu, Z., Xu, Z. Tags: Abstracts Source Type: research

02 Brain cancer prediction using machine learning methods and high-throughput molecular data
ConclusionOur study developed machine learning based models to predict GBM survival. The combination of molecular data and clinical variables can improve prediction accuracy. Moreover, it also brings us new insights into the molecular mechanisms underlying GBM cancer.AcknowledgementsSupported by the National Natural Science Foundation of China (61471078, 31270903), the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry, the Program for Liaoning Excellent Talents in University (LJQ2015011) and the Fundamental Research Funds for the Central Universities (3132016330, 3132014306...
Source: Journal of Investigative Medicine - December 5, 2017 Category: Research Authors: Ma, B., Chang, Q., Geng, Y., Liu, G., Dong, H., Sun, Y. Tags: Abstracts Source Type: research

01 Adsorption and wetting of protein affected by bionic surface texture desig nfor artificial organs application
ConclusionBionic surface texture has obvious influence on the adsorption and wetting of protein. Proper parameters of bionic surface texture may be of importance for the surface design in the real specific application.AcknowledgmentSupported by a project grant from the Science and Technology Innovation Fund (Grand No. 2014kct-03). (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - December 5, 2017 Category: Research Authors: W, W., BX, F., GM, C. Tags: Abstracts Source Type: research

25 Culture environmental management innovation optimisation of enrichment factor lactobacillus acidophilus
Conclusions The best ratio of enrichment medium was: glutamate, lysine, vitamin C. Culture temperature was 37°C, initial fermentation pH was 6.5, 4% inoculation, harvest time was 20 hours after fermentation. Acknowledgements Supported by a project grant from Longdong University doctoral research (Grant No. XYBE1605). Central finance forestry science and technology extension demonstration project [2015] ZYTG8 Qingyang science and technology support program (NK2011-41). (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - November 24, 2017 Category: Research Authors: Li, X., Wang, D., Zhang, Z., Zhu, Y., Jia, H. Tags: Abstracts Source Type: research

24 Danggui shaoyao powder improves diabetic nephropathy without altering blood glucose in streptozotocin-induced diabetic rats
Conclusion This study suggests that DSS could improve renal function in streptozotocin-induced DN model rats. The mechanism may be related to regulating the Th1/Th2 cell balance and improved lipid metabolism in DN rats. Acknowledgment Supported by a project grant from The National Natural Science Foundation of China (Grant No. 81603527), Science and technology project of Henan Province (Grant No. 162102310466), Key scientific research projects of Henan Province Colleges and Universities (Grant No. 16A360010), Henan University of Traditional Chinese Medicine Scientific and technological innovation talent support program (G...
Source: Journal of Investigative Medicine - November 24, 2017 Category: Research Authors: Li, X., Li, Z., Zhang, L., Zhang, Y., Liu, X., Zhao, X., Liu, W., Gao, A. Tags: Abstracts Source Type: research

23 Study on mirnas prediction and co-expression patterns of the human intronic mirnas with their host genes
Conclusions This study not only provides some effective means for research on miRNAs prediction and co-expression prediction of intronic miRNAs with their host genes, but also gives some solid foundation for future research in this field. Acknowledgements Supported by the National Natural Science Foundation of China (Grant No. 61402099). (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - November 24, 2017 Category: Research Authors: Wang, H., Li, B., Wu, M. Tags: Abstracts Source Type: research

22 In vivo evaluation of ethanol extract of forsythia suspensa (thunb.) vahl (fruit) in anti-inflammatory and analgesic activities
Conclusions These findings indicate that FSTV-ET can produce anti-inflammatory and analgesic activities in vivo, and the mechanism is likely to be related to inhibiting lipid peroxidation and inflammation. Acknowledgements Supported by project grants from the National Natural Science Foundation of China (Grant No. 81503269), the Funding Scheme for Young Key Teachers of Colleges and Universities in Henan Province (Grant No. 2014GGJS-072), and the Science and Technology Project of Zhengzhou (Grant No. 20150309). (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - November 24, 2017 Category: Research Authors: Wang, J., Cui, Y., Chen, S., XB, L., Feng, W., Cai, H., Chen, R. Tags: Abstracts Source Type: research

21 Effect of jinjiang granules on intestinal mucosal immunity in mice model
Conclusions Jinjiang granules can improve the immune function of the mice models of hypoimmunity. It also improves intestinal immune function. It prevents colds when given as the initial medicine. Acknowledgements The Central Plains scholars (162101510003), the team of outstanding scientific and technological innovation in Henan province (TCJ2014-391), Henan University of Traditional Chinese Medicine and deep processing of geoherbs Collaborative Innovation Centre (2012)188–2. (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - November 24, 2017 Category: Research Authors: Miao, M., Cao, L., Qiao, J., Zhang, R. Tags: Abstracts Source Type: research

20 Gut microbiota in human adults with irritable bowel syndrome differs from healthy controls
Background Recent evidence suggests that there is a link between irritable bowel syndrome (IBS) and microbiota in the gut. The onset and maintenance of IBS may be caused by gut microbiota, but the causes of the pathophysiology of this disorder are unknown. Method 25 patients who fulfilled Rome III criteria for IBS and 29 age- and gender-matched healthy controls were chosen in this study. The total bacterial DNA isolated from the two populations was investigated through amplicon pyrosequencing of the V3–V4 regions of the 16S ribosomal RNA gene. Results The composition of bacteria in the groups differed between healt...
Source: Journal of Investigative Medicine - November 24, 2017 Category: Research Authors: Liu, Y., Wang, Y., Wen, S., Zhang, T., Tang, L. Tags: Abstracts Source Type: research

19 Experimental study on postoperative adhesions between tendon and different tissues
Conclusion Postoperative adhesions between the tendon and different tissues differ. More tissue adhesion formed between the tendon and the subcutaneous tissue than between the tendon and the remnant sheath. (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - November 24, 2017 Category: Research Authors: Su, Y., Wang, W., Meng, X., Gu, G., Yu, M., Yan, Z., Ma, Y., Dong, X., Sun, Q., Zhao, D. Tags: Abstracts Source Type: research

18 Intermittent hypoxia improves atherosclerosis associated with upregulation of hif-1{alpha} and nf-{kappa}b in aortic arch and serum of rabbits
Objectives To investigate the role of HIF-1α and NF-B in intermittent hypoxia (IH) induced atherosclerosis in rabbits. Methods New-Zealand White rabbits were exposed to IH for 12 weeks (intermittent hypoxia of 21% O2 for 30 s and 8% O2 for 30 s, cyclically repeated for 8 h/day). We randomly assigned 48 male rabbits to groups of normoxia (RA) or IH. The rabbits in the RA group were continuously exposed to room air. After intervention of 4, 8, and 12 weeks, serum and aortic arch tissues were subjected to Elisa and immunohistochemical staining analyses respectively. The formation of atherosclerosis in the aortic arch w...
Source: Journal of Investigative Medicine - November 24, 2017 Category: Research Authors: Pang, J., Wang, B., Li, Y., Zhang, H., Xiang, W., Hao, X., Xue, H. Tags: Abstracts Source Type: research

17 Effect of salvia miltiorrhiza on tmmrna expression in coronary artery tissue of rats with high salt induced blood stasis
Objective To understand the effect of Salvia miltiorrhiza on the cardiovascular system by the expression of tissue TMmRNA, and to provide the scientific basis for the use of Salvia miltiorrhiza and a low salt diet for the prevention and treatment of cardiovascular and cerebrovascular diseases caused by high salt intake. Methods Thirty SD rats were randomly divided into a blank group, high salt group and Salvia miltiorrhiza group. The blank group was given intragastric distilled water and the high salt and the Salvia miltiorrhiza groups were treated with intragastric administration of 12% NaCl, for 30 consecutive days. Sev...
Source: Journal of Investigative Medicine - November 24, 2017 Category: Research Authors: Xia, L., Zhou, X., Tian, X., Zhao, Y., Fu, D., Xu, H. Tags: Abstracts Source Type: research